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TDMS Study 96010-03 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 05/27/03       
EXPERIMENT: 96010 TEST: 03                                                                                     TIME: 13:32:29       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 7775-09-9       
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                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 05/27/03       
EXPERIMENT: 96010 TEST: 03                                                                                     TIME: 13:32:29       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 7775-09-9       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF     WATER DISINFECTION BYPRODUCTS (SODIUM                                                                        
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
Adrenal Medulla                        Hyperplasia Focal                                                                            
Bone Marrow                            Fibrosis                                                                                     
                                       Hyperplasia                                                                                  
Bone Marrow: Myeloid Cell, Erythroid Cell                                                                                           
                                       Hyperplasia                                                                                  
Brain                                  Hemorrhage Focal                                                                             
Eye                                    Atrophy                                                                                      
Heart                                  Cardiomyopathy                                                                               
Intestine Large, Colon                 Edema                                                                                        
Kidney                                 Nephropathy                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
                                       Mixed Cell Focus                                                                             
Liver: Hepatocyte                      Vacuolization Cytoplasmic Focal                                                              
Liver: Hepatocyte, Centrilobular       Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Liver: Hepatocyte, Midzonal            Vacuolization Cytoplasmic                                                                    
Lymph Node: Pancreatic                 Angiectasis                                                                                  
                                       Hemorrhage                                                                                   
Mesentery: Fat                         Necrosis Focal                                                                               
Nose                                   Inflammation                                                                                 
Pancreas: Acinus                       Atrophy Focal                                                                                
Pituitary Gland: Pars Distalis         Cytoplasmic Alteration Focal                                                                 
Preputial Gland                        Inflammation Chronic                                                                         
Prostate                               Inflammation Chronic                                                                         
Prostate: Epithelium                   Hyperplasia Focal                                                                            
Spleen                                 Fibrosis Focal                                                                               
                                       Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Edema                                                                                        
Stomach, Forestomach: Epithelium       Hyperplasia                                                                                  
Stomach, Glandular                     Ulcer                                                                                        
Testes                                 Atrophy                                                                                      
Thyroid Gland: Follicle                Degeneration Cystic Focal                                                                    
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Urinary Bladder                        Edema                                                                                        
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Heart                                  Infiltration Cellular Mixed Cell                                                             
Kidney                                 Nephropathy                                                                                  
Kidney: Renal Tubule                   Accumulation, Hyaline Droplet                                                                
                                       Pigmentation                                                                                 
Liver                                  Clear Cell Focus                                                                             
                                       Congestion                                                                                   
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 05/27/03       
EXPERIMENT: 96010 TEST: 03                                                                                     TIME: 13:32:29       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: FARNELL, DANIEL R.                                                                                CAS: 7775-09-9       
                                       Hyperplasia Regenerative                                                                     
Lymph Node: Pancreatic                 Hemorrhage                                                                                   
                                       Hyperplasia                                                                                  
                                       Pigmentation                                                                                 
Mesentery: Fat                         Necrosis                                                                                     
Pituitary Gland                        Angiectasis                                                                                  
Pituitary Gland: Pars Distalis         Degeneration Cystic Focal                                                                    
                                       Hemorrhage Focal                                                                             
Pituitary Gland: Rathke's Cleft        Hemorrhage                                                                                   
Salivary Glands                        Atrophy Focal                                                                                
Spleen                                 Hematopoietic Cell Proliferation                                                             
Stomach, Forestomach                   Ulcer                                                                                        
Thyroid Gland: Follicle                Mineralization Focal                                                                         
Thyroid Gland: Follicular Cell         Hypertrophy                                                                                  
Uterus: Endometrium                    Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM            
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    7/49 (14%)   4/50 (8%)    3/50 (6%)   |2/50 (4%)    3/50 (6%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.39      7/43.91      4/44.29      3/43.62     |2/44.75      3/44.07      5/43.75      2/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         15.9%        9.0%         6.9%        |4.5%         6.8%         11.4%        4.3%         | 
|TERMINAL (d)       |     1/36 (3%)    3/27 (11%)   2/31 (7%)    2/28 (7%)   |2/37 (5%)    2/36 (6%)    2/33 (6%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      638          647          681         |729 (T)      623          651          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.504N     P=0.021 *    P=0.161      P=0.236     |P=0.521N     P=0.492      P=0.182      P=0.658N     | 
|POLY 3             |     P=0.449N     P=0.031 *    P=0.185      P=0.307     |P=0.537N     P=0.493      P=0.207      P=0.676N     | 
|POLY 1.5           |     P=0.443N     P=0.031 *    P=0.185      P=0.311     |P=0.550N     P=0.495      P=0.211      P=0.683N     | 
|POLY 6             |     P=0.465N     P=0.028 *    P=0.181      P=0.298     |P=0.526N     P=0.493      P=0.199      P=0.670N     | 
|LOGISTIC REGRESSION|     P=0.447N     P=0.032 *    P=0.184      P=0.292     |P=0.549N     P=0.491      P=0.201      P=0.658N     | 
|COCH-ARM / FISHERS |     P=0.440N     P=0.030 *    P=0.187      P=0.316     |P=0.574      P=0.500      P=0.218      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.127      (e)          (e)          (e)         |P=0.415N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.39      0/43.20      0/43.73      0/43.44     |2/45.21      1/43.69      1/43.90      2/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         2.3%         2.3%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |1/37 (3%)    1/36 (3%)    0/33 (0%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |594          729 (T)      511          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.544      P=0.509N     P=0.516N     P=0.660N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.535      P=0.512N     P=0.510N     P=0.680N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.527      P=0.508N     P=0.505N     P=0.685N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.541      P=0.517N     P=0.520N     P=0.676N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.477      P=0.497N     P=0.480N     P=0.685      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.513      P=0.500N     P=0.500N     P=0.691N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.546N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    3/49 (6%)    2/50 (4%)    4/50 (8%)   |1/50 (2%)    2/50 (4%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/44.25      3/44.27      2/43.73      4/44.01     |1/45.21      2/43.69      3/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     6.8%         6.8%         4.6%         9.1%        |2.2%         4.6%         6.9%         4.3%         | 
|TERMINAL (d)       |     2/36 (6%)    1/27 (4%)    2/31 (7%)    2/28 (7%)   |0/37 (0%)    2/36 (6%)    3/33 (9%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     381          555          729 (T)      590         |594          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.384      P=0.607      P=0.556N     P=0.416     |P=0.455      P=0.491      P=0.273      P=0.531      | 
|POLY 3             |     P=0.423      P=0.662N     P=0.505N     P=0.497     |P=0.441      P=0.488      P=0.289      P=0.514      | 
|POLY 1.5           |     P=0.429      P=0.660N     P=0.500N     P=0.504     |P=0.431      P=0.492      P=0.297      P=0.509      | 
|POLY 6             |     P=0.414      P=0.653      P=0.516N     P=0.484     |P=0.450      P=0.483      P=0.277      P=0.517      | 
|LOGISTIC REGRESSION|     P=0.450      P=0.549      P=0.484N     P=0.505     |P=0.435      P=0.503      P=0.302      P=0.472      | 
|COCH-ARM / FISHERS |     P=0.439      P=0.661N     P=0.490N     P=0.511     |P=0.411      P=0.500      P=0.309      P=0.500      | 
|ORDER RESTRICTED   |     P=0.453      (e)          (e)          (e)         |P=0.346      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.39      0/43.20      2/43.73      0/43.44     |0/44.75      1/43.69      0/43.24      1/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.6%         0.0%        |0.0%         2.3%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    2/31 (7%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      ---         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.493      (e)          P=0.206      (e)         |P=0.500      P=0.495      (e)          P=0.520      | 
|POLY 3             |     P=0.518      (e)          P=0.239      (e)         |P=0.488      P=0.495      (e)          P=0.510      | 
|POLY 1.5           |     P=0.523      (e)          P=0.240      (e)         |P=0.484      P=0.497      (e)          P=0.506      | 
|POLY 6             |     P=0.509      (e)          P=0.234      (e)         |P=0.491      P=0.494      (e)          P=0.513      | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.206      (e)         |(e)          P=0.495      (e)          P=0.520      | 
|COCH-ARM / FISHERS |     P=0.527      (e)          P=0.253      (e)         |P=0.478      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.249      (e)          (e)          (e)         |P=0.261      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.39      0/43.20      0/43.73      0/43.44     |1/45.20      1/43.69      0/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         2.3%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |595          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.409      P=0.757      P=0.505N     P=0.534      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.387      P=0.753      P=0.509N     P=0.514      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.384      P=0.756      P=0.505N     P=0.509      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.390      P=0.750      P=0.516N     P=0.517      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.376      P=0.754N     P=0.488N     P=0.472      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.376      P=0.753N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.293      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic Focal                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/49 (24%)  8/49 (16%)   7/50 (14%)   6/50 (12%)  |7/50 (14%)   13/50 (26%)  7/50 (14%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     12/43.86     8/43.98      7/44.37      6/44.12     |7/44.75      13/43.70     7/43.24      8/47.42      | 
|POLY-3 PERCENT (g) |     27.4%        18.2%        15.8%        13.6%       |15.6%        29.8%        16.2%        16.9%        | 
|TERMINAL (d)       |     10/36 (28%)  4/27 (15%)   5/31 (16%)   2/28 (7%)   |7/37 (19%)   12/36 (33%)  7/33 (21%)   6/41 (15%)   | 
|FIRST INCIDENCE    |     630          582          605          651         |729 (T)      727          729 (T)      644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.159N     P=0.429N     P=0.238N     P=0.201N    |P=0.226N     P=0.088      P=0.524      P=0.581      | 
|POLY 3             |     P=0.098N     P=0.220N     P=0.142N     P=0.089N    |P=0.253N     P=0.089      P=0.587      P=0.549      | 
|POLY 1.5           |     P=0.097N     P=0.217N     P=0.141N     P=0.086N    |P=0.272N     P=0.094      P=0.600      P=0.530      | 
|POLY 6             |     P=0.099N     P=0.238N     P=0.150N     P=0.096N    |P=0.234N     P=0.085      P=0.566      P=0.568      | 
|LOGISTIC REGRESSION|     P=0.101N     P=0.234N     P=0.150N     P=0.097N    |P=0.240N     P=0.082      P=0.524      P=0.555      | 
|COCH-ARM / FISHERS |     P=0.095N     P=0.226N     P=0.142N     P=0.088N    |P=0.303N     P=0.105      P=0.613N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.072N     (e)          (e)          (e)         |P=0.361N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   12/49 (24%)  9/50 (18%)   13/50 (26%) |3/50 (6%)    4/50 (8%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/44.37      12/45.22     9/44.62      13/45.65    |3/44.75      4/44.03      1/43.35      1/47.00      | 
|POLY-3 PERCENT (g) |     11.3%        26.5%        20.2%        28.5%       |6.7%         9.1%         2.3%         2.1%         | 
|TERMINAL (d)       |     2/36 (6%)    5/27 (19%)   5/31 (16%)   5/28 (18%)  |3/37 (8%)    3/36 (8%)    0/33 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     574          542          561          562         |729 (T)      636          703          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.093      P=0.037 *    P=0.159      P=0.028 *   |P=0.088N     P=0.487      P=0.350N     P=0.269N     | 
|POLY 3             |     P=0.116      P=0.055      P=0.194      P=0.035 *   |P=0.092N     P=0.491      P=0.317N     P=0.288N     | 
|POLY 1.5           |     P=0.118      P=0.056      P=0.199      P=0.036 *   |P=0.094N     P=0.493      P=0.311N     P=0.294N     | 
|POLY 6             |     P=0.111      P=0.050      P=0.181      P=0.033 *   |P=0.090N     P=0.491      P=0.326N     P=0.282N     | 
|LOGISTIC REGRESSION|     P=0.124      P=0.048 *    P=0.204      P=0.038 *   |P=0.089N     P=0.485      P=0.335N     P=0.269N     | 
|COCH-ARM / FISHERS |     P=0.121      P=0.054      P=0.205      P=0.037 *   |P=0.099N     P=0.500      P=0.309N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.031 *    (e)          (e)          (e)         |P=0.156N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.25      0/42.38      0/43.73      0/43.02     |0/44.75      0/43.02      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/36 (6%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189N     P=0.303N     P=0.272N     P=0.295N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.166N     P=0.241N     P=0.234N     P=0.238N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.168N     P=0.239N     P=0.232N     P=0.235N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.162N     P=0.249N     P=0.239N     P=0.244N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.189N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.169N     P=0.247N     P=0.237N     P=0.242N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.030N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/48 (58%)  35/48 (73%)  41/50 (82%)  40/49 (82%) |2/50 (4%)    1/49 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     28/45.07     35/45.91     41/47.90     40/46.97    |2/44.75      1/43.02      1/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     62.1%        76.2%        85.6%        85.2%       |4.5%         2.3%         2.3%         0.0%         | 
|TERMINAL (d)       |     24/36 (67%)  24/27 (89%)  30/31 (97%)  25/28 (89%) |2/37 (5%)    1/36 (3%)    1/33 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     469          542          209          443         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.006 **   P<0.001 **   P<0.001 **  |P=0.160N     P=0.510N     P=0.540N     P=0.216N     | 
|POLY 3             |     P=0.007 **   P=0.101      P=0.006 **   P=0.008 **  |P=0.162N     P=0.514N     P=0.512N     P=0.226N     | 
|POLY 1.5           |     P=0.008 **   P=0.102      P=0.007 **   P=0.008 **  |P=0.165N     P=0.512N     P=0.506N     P=0.230N     | 
|POLY 6             |     P=0.007 **   P=0.094      P=0.004 **   P=0.008 **  |P=0.160N     P=0.515N     P=0.522N     P=0.223N     | 
|LOGISTIC REGRESSION|     P=0.009 **   P=0.093      P=0.007 **   P=0.008 **  |P=0.160N     P=0.510N     P=0.540N     (e)          | 
|COCH-ARM / FISHERS |     P=0.012 *    P=0.098      P=0.009 **   P=0.011 *   |P=0.171N     P=0.508N     P=0.500N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.003 **   (e)          (e)          (e)         |P=0.109N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia Focal Histiocytic                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    0/49 (0%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.25      0/42.38      0/43.73      0/43.02     |0/44.75      0/43.02      2/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.6%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    2/33 (6%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.085      (e)          P=0.213      P=0.261      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.079      (e)          P=0.229      P=0.248      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.075      (e)          P=0.233      P=0.244      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.082      (e)          P=0.223      P=0.252      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.213      P=0.261      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.069      (e)          P=0.247      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.111      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Myeloid Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |7/50 (14%)   3/49 (6%)    2/50 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     0/43.25      0/42.38      0/43.73      0/43.02     |7/45.28      3/43.56      2/43.72      6/47.33      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |15.5%        6.9%         4.6%         12.7%        | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |6/37 (16%)   2/36 (6%)    1/33 (3%)    4/41 (10%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |566          563          587          670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.534N     P=0.173N     P=0.107N     P=0.430N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.558      P=0.173N     P=0.087N     P=0.466N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.549      P=0.171N     P=0.083N     P=0.479N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.565N     P=0.173N     P=0.093N     P=0.453N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.536      P=0.169N     P=0.082N     P=0.480N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.530      P=0.167N     P=0.080N     P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.182N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow: Myeloid Cell, Erythroid Cell                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    0/48 (0%)    0/50 (0%)    0/49 (0%)   |0/50 (0%)    2/49 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/43.25      0/42.38      0/43.73      0/43.02     |0/44.75      2/43.03      2/43.47      3/47.34      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         0.0%         0.0%        |0.0%         4.7%         4.6%         6.3%         | 
|TERMINAL (d)       |     2/36 (6%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          727          699          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189N     P=0.303N     P=0.272N     P=0.295N    |P=0.168      P=0.234      P=0.217      P=0.144      | 
|POLY 3             |     P=0.166N     P=0.241N     P=0.234N     P=0.238N    |P=0.156      P=0.228      P=0.231      P=0.129      | 
|POLY 1.5           |     P=0.168N     P=0.239N     P=0.232N     P=0.235N    |P=0.150      P=0.230      P=0.234      P=0.125      | 
|POLY 6             |     P=0.162N     P=0.249N     P=0.239N     P=0.244N    |P=0.163      P=0.228      P=0.226      P=0.133      | 
|LOGISTIC REGRESSION|     P=0.189N     (e)          (e)          (e)         |P=0.150      P=0.227      P=0.233      P=0.114      | 
|COCH-ARM / FISHERS |     P=0.169N     P=0.247N     P=0.237N     P=0.242N    |P=0.140      P=0.242      P=0.247      P=0.121      | 
|ORDER RESTRICTED   |     P=0.030N*    (e)          (e)          (e)         |P=0.085      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   6/50 (12%)   7/50 (14%)   6/50 (12%)  |9/49 (18%)   9/50 (18%)   10/50 (20%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     6/44.21      6/44.13      7/45.18      6/44.06     |9/44.99      9/44.67      10/45.11     9/48.06      | 
|POLY-3 PERCENT (g) |     13.6%        13.6%        15.5%        13.6%       |20.0%        20.2%        22.2%        18.7%        | 
|TERMINAL (d)       |     4/36 (11%)   3/27 (11%)   2/31 (7%)    2/28 (7%)   |4/37 (11%)   5/36 (14%)   5/33 (15%)   6/41 (15%)   | 
|FIRST INCIDENCE    |     630          672          566          671         |595          636          547          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.468      P=0.463      P=0.442      P=0.505     |P=0.471N     P=0.573      P=0.420      P=0.517N     | 
|POLY 3             |     P=0.530      P=0.620      P=0.517      P=0.619     |P=0.491N     P=0.597      P=0.503      P=0.542N     | 
|POLY 1.5           |     P=0.530      P=0.615N     P=0.510      P=0.619N    |P=0.511N     P=0.601N     P=0.512      P=0.556N     | 
|POLY 6             |     P=0.528      P=0.597      P=0.516      P=0.606     |P=0.479N     P=0.590      P=0.485      P=0.534N     | 
|LOGISTIC REGRESSION|     P=0.528      P=0.614      P=0.500      P=0.618     |P=0.515      P=0.589N     P=0.530      P=0.578      | 
|COCH-ARM / FISHERS |     P=0.530      P=0.620N     P=0.500      P=0.620N    |P=0.539      P=0.584N     P=0.520      P=0.584N     | 
|ORDER RESTRICTED   |     P=0.684      (e)          (e)          (e)         |P=0.625N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    4/50 (8%)    6/50 (12%)  |0/49 (0%)    4/50 (8%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/44.42      2/44.69      4/44.88      6/44.81     |0/43.79      4/44.02      3/44.15      2/47.14      | 
|POLY-3 PERCENT (g) |     4.5%         4.5%         8.9%         13.4%       |0.0%         9.1%         6.8%         4.2%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    1/28 (4%)   |0/37 (0%)    3/36 (8%)    0/33 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     545          582          605          465         |---          639          615          693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.052      P=0.688N     P=0.336      P=0.122     |P=0.547      P=0.061      P=0.115      P=0.259      | 
|POLY 3             |     P=0.048 *    P=0.692N     P=0.342      P=0.135     |P=0.545      P=0.061      P=0.120      P=0.254      | 
|POLY 1.5           |     P=0.049 *    P=0.690N     P=0.340      P=0.136     |P=0.532      P=0.061      P=0.121      P=0.249      | 
|POLY 6             |     P=0.048 *    P=0.687      P=0.340      P=0.130     |P=0.557      P=0.060      P=0.117      P=0.258      | 
|LOGISTIC REGRESSION|     P=0.047 *    P=0.588      P=0.339      P=0.120     |P=0.497      P=0.063      P=0.129      P=0.248      | 
|COCH-ARM / FISHERS |     P=0.048 *    P=0.691N     P=0.339      P=0.134     |P=0.511      P=0.061      P=0.125      P=0.253      | 
|ORDER RESTRICTED   |     P=0.089      (e)          (e)          (e)         |P=0.108      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/49 (10%)   2/50 (4%)    6/50 (12%)   1/49 (2%)    | 
|POLY-3 RATE (b)    |                                                        |5/43.75      2/44.38      6/43.76      1/46.00      | 
|POLY-3 PERCENT (g) |                                                        |11.4%        4.5%         13.7%        2.2%         | 
|TERMINAL (d)       |                                                        |5/36 (14%)   0/36 (0%)    5/33 (15%)   1/40 (3%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      623          573          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.193N     P=0.222N     P=0.446      P=0.080N     | 
|POLY 3             |                                                        |P=0.196N     P=0.210N     P=0.500      P=0.090N     | 
|POLY 1.5           |                                                        |P=0.206N     P=0.211N     P=0.507      P=0.094N     | 
|POLY 6             |                                                        |P=0.188N     P=0.207N     P=0.487      P=0.086N     | 
|LOGISTIC REGRESSION|                                                        |P=0.214N     P=0.213N     P=0.480      P=0.080N     | 
|COCH-ARM / FISHERS |                                                        |P=0.227N     P=0.210N     P=0.514      P=0.102N     | 
|ORDER RESTRICTED   |                                                        |P=0.074N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/49 (2%)    4/50 (8%)    3/50 (6%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.12      4/44.07      3/43.24      1/46.00      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         9.1%         6.9%         2.2%         | 
|TERMINAL (d)       |                                                        |0/36 (0%)    2/36 (6%)    3/33 (9%)    1/40 (3%)    | 
|FIRST INCIDENCE    |                                                        |623          626          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.298N     P=0.186      P=0.280      P=0.736N     | 
|POLY 3             |                                                        |P=0.314N     P=0.178      P=0.298      P=0.751N     | 
|POLY 1.5           |                                                        |P=0.320N     P=0.180      P=0.305      P=0.754N     | 
|POLY 6             |                                                        |P=0.309N     P=0.176      P=0.286      P=0.749N     | 
|LOGISTIC REGRESSION|                                                        |P=0.319N     P=0.187      P=0.305      P=0.742      | 
|COCH-ARM / FISHERS |                                                        |P=0.333N     P=0.187      P=0.316      P=0.753N     | 
|ORDER RESTRICTED   |                                                        |P=0.312N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |6/49 (12%)   2/50 (4%)    1/50 (2%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |                                                        |6/43.79      2/43.69      1/43.24      3/46.00      | 
|POLY-3 PERCENT (g) |                                                        |13.7%        4.6%         2.3%         6.5%         | 
|TERMINAL (d)       |                                                        |5/36 (14%)   2/36 (6%)    1/33 (3%)    3/40 (8%)    | 
|FIRST INCIDENCE    |                                                        |718          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.239N     P=0.137N     P=0.076N     P=0.197N     | 
|POLY 3             |                                                        |P=0.257N     P=0.133N     P=0.057N     P=0.218N     | 
|POLY 1.5           |                                                        |P=0.263N     P=0.131N     P=0.055N     P=0.227N     | 
|POLY 6             |                                                        |P=0.252N     P=0.134N     P=0.061N     P=0.210N     | 
|LOGISTIC REGRESSION|                                                        |P=0.250N     P=0.137N     P=0.073N     P=0.208N     | 
|COCH-ARM / FISHERS |                                                        |P=0.276N     P=0.128N     P=0.053N     P=0.243N     | 
|ORDER RESTRICTED   |                                                        |P=0.057N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/44.37      1/44.23      0/43.73      2/43.91     |                                                    | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         0.0%         4.6%        |                                                    | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    1/28 (4%)   |                                                    | 
|FIRST INCIDENCE    |     511          605          ---          590         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.369      P=0.746N     P=0.492N     P=0.479     |                                                    | 
|POLY 3             |     P=0.374      P=0.760      P=0.503N     P=0.496     |                                                    | 
|POLY 1.5           |     P=0.375      P=0.759N     P=0.501N     P=0.499     |                                                    | 
|POLY 6             |     P=0.371      P=0.753      P=0.507N     P=0.488     |                                                    | 
|LOGISTIC REGRESSION|     P=0.380      P=0.625      P=0.454N     P=0.461     |                                                    | 
|COCH-ARM / FISHERS |     P=0.376      P=0.753N     P=0.500N     P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.269      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    0/46 (0%)    2/50 (4%)   |1/50 (2%)    0/49 (0%)    0/47 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.72      0/42.69      0/41.78      2/43.44     |1/44.75      0/43.02      0/40.76      1/47.34      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.6%        |2.2%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    2/28 (7%)   |1/37 (3%)    0/36 (0%)    0/32 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |729 (T)      ---          ---          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035 *    (e)          (e)          P=0.185     |P=0.545      P=0.505N     P=0.529N     P=0.734N     | 
|POLY 3             |     P=0.044 *    (e)          (e)          P=0.236     |P=0.538      P=0.508N     P=0.519N     P=0.748N     | 
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.237     |P=0.532      P=0.507N     P=0.516N     P=0.753N     | 
|POLY 6             |     P=0.043 *    (e)          (e)          P=0.230     |P=0.542      P=0.508N     P=0.523N     P=0.743N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.185     |P=0.512      (e)          (e)          P=0.747      | 
|COCH-ARM / FISHERS |     P=0.045 *    (e)          (e)          P=0.247     |P=0.522      P=0.505N     P=0.515N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |P=0.395N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/48 (4%)    1/46 (2%)    2/50 (4%)   |2/50 (4%)    3/49 (6%)    1/47 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.72      2/42.69      1/41.99      2/43.48     |2/44.75      3/43.02      1/40.76      2/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.4%         4.6%        |4.5%         7.0%         2.5%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    2/27 (7%)    0/31 (0%)    1/28 (4%)   |2/37 (5%)    3/36 (8%)    1/32 (3%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      673          718         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.287      P=0.177      P=0.495      P=0.194     |P=0.394N     P=0.487      P=0.551N     P=0.658N     | 
|POLY 3             |     P=0.321      P=0.232      P=0.492      P=0.236     |P=0.419N     P=0.482      P=0.532N     P=0.676N     | 
|POLY 1.5           |     P=0.323      P=0.232      P=0.488      P=0.238     |P=0.424N     P=0.484      P=0.527N     P=0.683N     | 
|POLY 6             |     P=0.314      P=0.227      P=0.494      P=0.230     |P=0.415N     P=0.481      P=0.541N     P=0.670N     | 
|LOGISTIC REGRESSION|     P=0.313      P=0.177      P=0.479      P=0.216     |P=0.394N     P=0.487      P=0.551N     P=0.658N     | 
|COCH-ARM / FISHERS |     P=0.321      P=0.237      P=0.479      P=0.247     |P=0.434N     P=0.490      P=0.523N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.153      (e)          (e)          (e)         |P=0.469N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Retina                                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/48 (4%)    1/46 (2%)    2/50 (4%)   |1/50 (2%)    2/49 (4%)    1/47 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.72      2/42.69      1/41.99      2/43.48     |1/44.75      2/43.02      1/40.76      2/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         4.7%         2.4%         4.6%        |2.2%         4.7%         2.5%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    2/27 (7%)    0/31 (0%)    1/28 (4%)   |1/37 (3%)    2/36 (6%)    1/32 (3%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      673          718         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.287      P=0.177      P=0.495      P=0.194     |P=0.524      P=0.490      P=0.729      P=0.536      | 
|POLY 3             |     P=0.321      P=0.232      P=0.492      P=0.236     |P=0.508      P=0.486      P=0.740      P=0.517      | 
|POLY 1.5           |     P=0.323      P=0.232      P=0.488      P=0.238     |P=0.501      P=0.488      P=0.743      P=0.511      | 
|POLY 6             |     P=0.314      P=0.227      P=0.494      P=0.230     |P=0.514      P=0.485      P=0.735      P=0.523      | 
|LOGISTIC REGRESSION|     P=0.313      P=0.177      P=0.479      P=0.216     |P=0.524      P=0.490      P=0.729      P=0.536      | 
|COCH-ARM / FISHERS |     P=0.321      P=0.237      P=0.479      P=0.247     |P=0.487      P=0.492      P=0.737      P=0.500      | 
|ORDER RESTRICTED   |     P=0.153      (e)          (e)          (e)         |P=0.465      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Hyperplasia Focal Histiocytic                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    1/49 (2%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.39      1/43.21      1/43.46      1/43.44     |2/44.75      0/43.69      1/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.3%         2.3%        |4.5%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/31 (3%)    1/28 (4%)   |2/37 (5%)    0/36 (0%)    1/33 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          726          729 (T)      729 (T)     |729 (T)      ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.383      P=0.450      P=0.470      P=0.450     |P=0.255N     P=0.244N     P=0.540N     P=0.216N     | 
|POLY 3             |     P=0.418      P=0.499      P=0.500      P=0.500     |P=0.256N     P=0.242N     P=0.512N     P=0.226N     | 
|POLY 1.5           |     P=0.422      P=0.501      P=0.501      P=0.503     |P=0.261N     P=0.241N     P=0.506N     P=0.230N     | 
|POLY 6             |     P=0.409      P=0.493      P=0.497      P=0.494     |P=0.252N     P=0.244N     P=0.522N     P=0.223N     | 
|LOGISTIC REGRESSION|     P=0.388      P=0.472      P=0.470      P=0.450     |P=0.255N     (e)          P=0.540N     (e)          | 
|COCH-ARM / FISHERS |     P=0.425      P=0.500      P=0.500      P=0.505     |P=0.270N     P=0.247N     P=0.500N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.327      (e)          (e)          (e)         |P=0.067N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    1/49 (2%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.39      1/43.32      1/43.46      1/43.44     |0/44.75      1/43.69      1/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.3%         2.3%        |0.0%         2.3%         2.3%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/31 (3%)    1/28 (4%)   |0/37 (0%)    1/36 (3%)    1/33 (3%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          699          729 (T)      729 (T)     |---          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.394      P=0.473      P=0.470      P=0.450     |P=0.201      P=0.495      P=0.477      P=0.261      | 
|POLY 3             |     P=0.418      P=0.500      P=0.500      P=0.500     |P=0.186      P=0.495      P=0.493      P=0.248      | 
|POLY 1.5           |     P=0.422      P=0.501      P=0.501      P=0.503     |P=0.182      P=0.497      P=0.496      P=0.244      | 
|POLY 6             |     P=0.409      P=0.494      P=0.497      P=0.494     |P=0.191      P=0.494      P=0.488      P=0.252      | 
|LOGISTIC REGRESSION|     P=0.412      P=0.500      P=0.470      P=0.450     |(e)          P=0.495      P=0.477      P=0.261      | 
|COCH-ARM / FISHERS |     P=0.425      P=0.500      P=0.500      P=0.505     |P=0.172      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.328      (e)          (e)          (e)         |P=0.127      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   3/50 (6%)    7/50 (14%)   10/50 (20%) |4/50 (8%)    2/50 (4%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     6/44.93      3/44.76      7/44.56      10/44.68    |4/45.84      2/44.23      0/43.24      2/47.23      | 
|POLY-3 PERCENT (g) |     13.4%        6.7%         15.7%        22.4%       |8.7%         4.5%         0.0%         4.2%         | 
|TERMINAL (d)       |     4/36 (11%)   1/27 (4%)    5/31 (16%)   8/28 (29%)  |2/37 (5%)    1/36 (3%)    0/33 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     381          555          475          443         |555          563          ---          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.029 *    P=0.324N     P=0.418      P=0.115     |P=0.228N     P=0.355N     P=0.074N     P=0.304N     | 
|POLY 3             |     P=0.040 *    P=0.243N     P=0.494      P=0.200     |P=0.244N     P=0.354N     P=0.068N     P=0.324N     | 
|POLY 1.5           |     P=0.041 *    P=0.240N     P=0.496      P=0.206     |P=0.245N     P=0.348N     P=0.064N     P=0.328N     | 
|POLY 6             |     P=0.037 *    P=0.256N     P=0.481      P=0.185     |P=0.243N     P=0.360N     P=0.074N     P=0.320N     | 
|LOGISTIC REGRESSION|     P=0.043 *    P=0.296N     P=0.500      P=0.202     |P=0.293N     P=0.302N     P=0.056N     P=0.416N     | 
|COCH-ARM / FISHERS |     P=0.043 *    P=0.243N     P=0.500      P=0.207     |P=0.250N     P=0.339N     P=0.059N     P=0.339N     | 
|ORDER RESTRICTED   |     P=0.070      (e)          (e)          (e)         |P=0.092N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/44.52      1/44.34      0/43.73      2/43.44     |0/44.75      1/43.69      1/44.08      4/47.00      | 
|POLY-3 PERCENT (g) |     4.5%         2.3%         0.0%         4.6%        |0.0%         2.3%         2.3%         8.5%         | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    0/31 (0%)    2/28 (7%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    4/41 (10%)   | 
|FIRST INCIDENCE    |     423          562          ---          729 (T)     |---          729 (T)      401          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.537      P=0.521N     P=0.256N     P=0.627     |P=0.029 *    P=0.495      P=0.500      P=0.077      | 
|POLY 3             |     P=0.556      P=0.501N     P=0.241N     P=0.685     |P=0.023 *    P=0.495      P=0.497      P=0.067      | 
|POLY 1.5           |     P=0.558      P=0.498N     P=0.240N     P=0.690     |P=0.022 *    P=0.497      P=0.499      P=0.065      | 
|POLY 6             |     P=0.554      P=0.512N     P=0.245N     P=0.675     |P=0.023 *    P=0.494      P=0.492      P=0.069      | 
|LOGISTIC REGRESSION|     P=0.569      P=0.707N     P=0.215N     P=0.685     |P=0.015 *    P=0.495      (e)          P=0.077      | 
|COCH-ARM / FISHERS |     P=0.563      P=0.500N     P=0.247N     P=0.691N    |P=0.021 *    P=0.500      P=0.500      P=0.059      | 
|ORDER RESTRICTED   |     P=0.404      (e)          (e)          (e)         |P=0.014 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.05      1/43.83      2/43.84      2/43.48     |1/45.12      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         4.6%         4.6%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/31 (3%)    1/28 (4%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     636          721          703          718         |623          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.285      P=0.737      P=0.473      P=0.456     |P=0.353N     P=0.495N     P=0.510N     P=0.478N     | 
|POLY 3             |     P=0.310      P=0.760      P=0.498      P=0.495     |P=0.364N     P=0.506N     P=0.508N     P=0.492N     | 
|POLY 1.5           |     P=0.313      P=0.759N     P=0.500      P=0.499     |P=0.363N     P=0.504N     P=0.504N     P=0.495N     | 
|POLY 6             |     P=0.304      P=0.752      P=0.492      P=0.485     |P=0.364N     P=0.509N     P=0.515N     P=0.490N     | 
|LOGISTIC REGRESSION|     P=0.311      P=0.759      P=0.500      P=0.500     |P=0.397N     P=0.476N     P=0.489N     P=0.575N     | 
|COCH-ARM / FISHERS |     P=0.314      P=0.753N     P=0.500      P=0.500     |P=0.363N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.437      (e)          (e)          (e)         |P=0.113N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Colon                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/47 (0%)    0/44 (0%)    2/49 (4%)   |0/50 (0%)    0/48 (0%)    0/46 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.19      0/42.02      0/40.50      2/43.64     |0/44.75      0/42.56      0/40.74      0/46.14      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          644         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045 *    (e)          (e)          P=0.239     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.045 *    (e)          (e)          P=0.239     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.241     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.045 *    (e)          (e)          P=0.235     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.047 *    (e)          (e)          P=0.240     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.030 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      2/43.38      0/43.46      0/43.44     |0/44.75      0/43.02      0/42.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/32 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          693          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.253N     P=0.205      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.231N     P=0.235      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.231N     P=0.236      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.236N     P=0.230      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.236N     P=0.234      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.235N     P=0.242      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.247N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/46 (0%)    0/49 (0%)    0/49 (0%)   |1/50 (2%)    0/49 (0%)    0/47 (0%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/40.79      0/43.46      0/43.02     |1/44.75      0/43.02      0/41.16      2/45.24      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |1/37 (3%)    0/36 (0%)    0/32 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.221      P=0.505N     P=0.529N     P=0.523      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.201      P=0.508N     P=0.517N     P=0.504      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.197      P=0.507N     P=0.515N     P=0.494      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.206      P=0.508N     P=0.520N     P=0.515      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.159      (e)          (e)          P=0.416      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.189      P=0.505N     P=0.515N     P=0.477      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.137      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/46 (0%)    0/49 (0%)    0/49 (0%)   |1/50 (2%)    2/49 (4%)    0/47 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/42.29      0/40.79      0/43.46      0/43.02     |1/44.75      2/43.81      0/41.16      0/44.65      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         4.6%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |1/37 (3%)    1/36 (3%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      433          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.122N     P=0.491      P=0.529N     P=0.484N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.130N     P=0.493      P=0.517N     P=0.500N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.131N     P=0.492      P=0.515N     P=0.505N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.129N     P=0.493      P=0.520N     P=0.495N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.156N     P=0.528      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.132N     P=0.492      P=0.515N     P=0.515N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.164N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/47 (96%)  44/46 (96%)  48/49 (98%)  47/49 (96%) |43/50 (86%)  41/49 (84%)  37/47 (79%)  38/47 (81%)  | 
|POLY-3 RATE (b)    |     45/46.15     44/45.61     48/48.63     47/48.25    |43/46.87     41/45.73     37/45.01     38/46.14     | 
|POLY-3 PERCENT (g) |     97.5%        96.5%        98.7%        97.4%       |91.7%        89.7%        82.2%        82.4%        | 
|TERMINAL (d)       |     36/36 (100%) 26/27 (96%)  31/31 (100%) 28/28 (100%)|36/37 (97%)  34/36 (94%)  27/32 (84%)  33/40 (83%)  | 
|FIRST INCIDENCE    |     381          542          209          443         |423          433          401          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.090      P=0.082      P=0.079      P=0.037 *   |P=0.044N*    P=0.518N     P=0.513N     P=0.054N     | 
|POLY 3             |     P=0.531      P=0.643N     P=0.661      P=0.768N    |P=0.071N     P=0.506N     P=0.122N     P=0.133N     | 
|POLY 1.5           |     P=0.516      P=0.665N     P=0.567      P=0.729     |P=0.134N     P=0.517N     P=0.171N     P=0.214N     | 
|POLY 6             |     P=0.599      P=0.599N     P=0.856      P=0.748N    |P=0.030N*    P=0.442N     P=0.079N     P=0.063N     | 
|LOGISTIC REGRESSION|     P=0.506      P=0.647N     P=0.453      P=0.698     |P=0.100N     P=0.594N     P=0.262N     P=0.145N     | 
|COCH-ARM / FISHERS |     P=0.529      P=0.683N     P=0.484      P=0.676     |P=0.271N     P=0.483N     P=0.250N     P=0.341N     | 
|ORDER RESTRICTED   |     P=0.551      (e)          (e)          (e)         |P=0.114N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    1/46 (2%)    4/49 (8%)    2/49 (4%)   |5/50 (10%)   12/49 (24%)  11/47 (23%)  5/47 (11%)   | 
|POLY-3 RATE (b)    |     0/42.29      1/40.93      4/44.47      2/43.78     |5/44.75      12/43.39     11/42.87     5/44.99      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         9.0%         4.6%        |11.2%        27.7%        25.7%        11.1%        | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |5/37 (14%)   10/36 (28%)  7/32 (22%)   4/40 (10%)   | 
|FIRST INCIDENCE    |     ---          695          561          590         |729 (T)      644          511          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.151      P=0.473      P=0.064      P=0.250     |P=0.213N     P=0.048 *    P=0.056      P=0.578N     | 
|POLY 3             |     P=0.163      P=0.493      P=0.066      P=0.245     |P=0.230N     P=0.043 *    P=0.067      P=0.627N     | 
|POLY 1.5           |     P=0.164      P=0.496      P=0.066      P=0.246     |P=0.257N     P=0.044 *    P=0.067      P=0.617      | 
|POLY 6             |     P=0.160      P=0.488      P=0.066      P=0.241     |P=0.203N     P=0.043 *    P=0.068      P=0.608N     | 
|LOGISTIC REGRESSION|     P=0.173      P=0.496      P=0.071      P=0.238     |P=0.270N     P=0.042 *    P=0.065      P=0.626N     | 
|COCH-ARM / FISHERS |     P=0.166      P=0.495      P=0.064      P=0.258     |P=0.303N     P=0.049 *    P=0.066      P=0.590      | 
|ORDER RESTRICTED   |     P=0.082      (e)          (e)          (e)         |P=0.156N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/47 (9%)    4/46 (9%)    1/49 (2%)    4/49 (8%)   |2/50 (4%)    1/49 (2%)    4/47 (9%)    4/47 (9%)    | 
|POLY-3 RATE (b)    |     4/44.87      4/42.55      1/44.00      4/44.46     |2/45.84      1/43.82      4/43.35      4/46.30      | 
|POLY-3 PERCENT (g) |     8.9%         9.4%         2.3%         9.0%        |4.4%         2.3%         9.2%         8.6%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/32 (0%)    1/40 (3%)    | 
|FIRST INCIDENCE    |     381          542          561          562         |555          423          511          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.475N     P=0.622N     P=0.178N     P=0.627N    |P=0.146      P=0.512N     P=0.340      P=0.367      | 
|POLY 3             |     P=0.465N     P=0.614      P=0.185N     P=0.638     |P=0.133      P=0.516N     P=0.312      P=0.342      | 
|POLY 1.5           |     P=0.457N     P=0.622      P=0.178N     P=0.637N    |P=0.122      P=0.512N     P=0.311      P=0.330      | 
|POLY 6             |     P=0.475N     P=0.599      P=0.195N     P=0.624     |P=0.145      P=0.519N     P=0.309      P=0.355      | 
|LOGISTIC REGRESSION|     P=0.378N     P=0.494      P=0.128N     P=0.654N    |P=0.006 **   P=0.361N     P=0.293      P=0.078      | 
|COCH-ARM / FISHERS |     P=0.444N     P=0.631      P=0.168N     P=0.619N    |P=0.104      P=0.508N     P=0.310      P=0.310      | 
|ORDER RESTRICTED   |     P=0.415N     (e)          (e)          (e)         |P=0.203      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/48 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/43.72      1/44.06      1/42.98      3/43.51     |0/44.75      0/43.69      2/43.36      0/47.00      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         2.3%         6.9%        |0.0%         0.0%         4.6%         0.0%         | 
|TERMINAL (d)       |     2/36 (6%)    0/27 (0%)    0/31 (0%)    2/28 (7%)   |0/37 (0%)    0/36 (0%)    1/33 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      660          703          710         |---          ---          699          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.255      P=0.566N     P=0.544N     P=0.396     |P=0.539      (e)          P=0.219      (e)          | 
|POLY 3             |     P=0.287      P=0.497N     P=0.506N     P=0.498     |P=0.562      (e)          P=0.230      (e)          | 
|POLY 1.5           |     P=0.287      P=0.496N     P=0.509N     P=0.501     |P=0.547      (e)          P=0.234      (e)          | 
|POLY 6             |     P=0.285      P=0.506N     P=0.507N     P=0.488     |P=0.575      (e)          P=0.225      (e)          | 
|LOGISTIC REGRESSION|     P=0.283      P=0.500N     P=0.512N     P=0.447     |P=0.534      (e)          P=0.226      (e)          | 
|COCH-ARM / FISHERS |     P=0.288      P=0.500N     P=0.515N     P=0.500     |P=0.522      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.288      (e)          (e)          (e)         |P=0.241      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  30/50 (60%)  33/48 (69%)  29/50 (58%) |42/50 (84%)  44/50 (88%)  41/50 (82%)  42/50 (84%)  | 
|POLY-3 RATE (b)    |     27/43.72     30/45.40     33/43.75     29/45.12    |42/48.62     44/48.60     41/47.28     42/48.90     | 
|POLY-3 PERCENT (g) |     61.8%        66.1%        75.4%        64.3%       |86.4%        90.5%        86.7%        85.9%        | 
|TERMINAL (d)       |     27/36 (75%)  24/27 (89%)  30/31 (97%)  23/28 (82%) |34/37 (92%)  33/36 (92%)  32/33 (97%)  37/41 (90%)  | 
|FIRST INCIDENCE    |     729 (T)      542          576          443         |423          365          401          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.100      P=0.009 **   P=0.003 **   P=0.037 *   |P=0.132N     P=0.331      P=0.326      P=0.249N     | 
|POLY 3             |     P=0.431      P=0.416      P=0.111      P=0.490     |P=0.378N     P=0.368      P=0.607      P=0.592N     | 
|POLY 1.5           |     P=0.416      P=0.399      P=0.104      P=0.469     |P=0.381N     P=0.366      P=0.576N     P=0.596N     | 
|POLY 6             |     P=0.441      P=0.393      P=0.105      P=0.490     |P=0.397N     P=0.389      P=0.519      P=0.595N     | 
|LOGISTIC REGRESSION|     P=0.359      P=0.207      P=0.042 *    P=0.339     |P=0.302N     P=0.360      P=0.534N     P=0.546N     | 
|COCH-ARM / FISHERS |     P=0.390      P=0.343      P=0.098      P=0.420     |P=0.401N     P=0.387      P=0.500N     P=0.607N     | 
|ORDER RESTRICTED   |     P=0.315      (e)          (e)          (e)         |P=0.535N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Cholangiofibrosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/48 (2%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/43.72      1/43.80      1/43.39      1/43.44     |1/44.75      0/43.69      1/43.58      3/47.23      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         2.3%         2.3%        |2.2%         0.0%         2.3%         6.4%         | 
|TERMINAL (d)       |     2/36 (6%)    1/27 (4%)    0/31 (0%)    1/28 (4%)   |1/37 (3%)    0/36 (0%)    0/33 (0%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      576          729 (T)     |729 (T)      ---          636          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.471N     P=0.600N     P=0.527N     P=0.588N    |P=0.094      P=0.505N     P=0.742      P=0.345      | 
|POLY 3             |     P=0.439N     P=0.499N     P=0.503N     P=0.502N    |P=0.080      P=0.505N     P=0.755      P=0.325      | 
|POLY 1.5           |     P=0.440N     P=0.497N     P=0.507N     P=0.500N    |P=0.077      P=0.503N     P=0.758      P=0.318      | 
|POLY 6             |     P=0.437N     P=0.510N     P=0.502N     P=0.511N    |P=0.083      P=0.506N     P=0.750      P=0.333      | 
|LOGISTIC REGRESSION|     P=0.440N     P=0.600N     P=0.518N     P=0.588N    |P=0.072      (e)          P=0.760N     P=0.319      | 
|COCH-ARM / FISHERS |     P=0.440N     P=0.500N     P=0.515N     P=0.500N    |P=0.072      P=0.500N     P=0.753N     P=0.309      | 
|ORDER RESTRICTED   |     P=0.417N     (e)          (e)          (e)         |P=0.094      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/50 (42%)  18/50 (36%)  29/48 (60%)  15/50 (30%) |6/50 (12%)   16/50 (32%)  18/50 (36%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     21/43.72     18/43.86     29/43.27     15/43.44    |6/45.28      16/44.71     18/43.24     10/47.00     | 
|POLY-3 PERCENT (g) |     48.0%        41.0%        67.0%        34.5%       |13.3%        35.8%        41.6%        21.3%        | 
|TERMINAL (d)       |     21/36 (58%)  17/27 (63%)  27/31 (87%)  15/28 (54%) |5/37 (14%)   14/36 (39%)  18/33 (55%)  10/41 (24%)  | 
|FIRST INCIDENCE    |     729 (T)      714          660          729 (T)     |566          511          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.518N     P=0.355      P=0.004 **   P=0.450N    |P=0.490N     P=0.013 *    P<0.001 **   P=0.272      | 
|POLY 3             |     P=0.293N     P=0.325N     P=0.050      P=0.138N    |P=0.526      P=0.010 *    P=0.002 **   P=0.229      | 
|POLY 1.5           |     P=0.294N     P=0.320N     P=0.050      P=0.138N    |P=0.505      P=0.011 *    P=0.003 **   P=0.221      | 
|POLY 6             |     P=0.303N     P=0.368N     P=0.043 *    P=0.154N    |P=0.542      P=0.010 *    P<0.001 **   P=0.235      | 
|LOGISTIC REGRESSION|     P=0.456N     P=0.479      P=0.012 *    P=0.450N    |P=0.526N     P=0.013 *    P=0.002 **   P=0.242      | 
|COCH-ARM / FISHERS |     P=0.302N     P=0.341N     P=0.052      P=0.149N    |P=0.465      P=0.014 *    P=0.005 **   P=0.207      | 
|ORDER RESTRICTED   |     P=0.063N     (e)          (e)          (e)         |P=0.020 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/48 (0%)    0/50 (0%)   |6/50 (12%)   2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.72      2/44.50      0/42.88      0/43.44     |6/44.75      2/44.07      2/43.82      1/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         0.0%        |13.4%        4.5%         4.6%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |6/37 (16%)   1/36 (3%)    1/33 (3%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     ---          555          ---          ---         |729 (T)      623          547          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.241N     P=0.240      (e)          (e)         |P=0.059N     P=0.142N     P=0.169N     P=0.043N*    | 
|POLY 3             |     P=0.233N     P=0.241      (e)          (e)         |P=0.059N     P=0.137N     P=0.139N     P=0.048N*    | 
|POLY 1.5           |     P=0.233N     P=0.241      (e)          (e)         |P=0.062N     P=0.137N     P=0.136N     P=0.051N     | 
|POLY 6             |     P=0.237N     P=0.236      (e)          (e)         |P=0.057N     P=0.137N     P=0.145N     P=0.046N*    | 
|LOGISTIC REGRESSION|     P=0.234N     P=0.174      (e)          (e)         |P=0.065N     P=0.142N     P=0.142N     P=0.043N*    | 
|COCH-ARM / FISHERS |     P=0.238N     P=0.247      (e)          (e)         |P=0.069N     P=0.134N     P=0.134N     P=0.056N     | 
|ORDER RESTRICTED   |     P=0.252N     (e)          (e)          (e)         |P=0.014N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  9/50 (18%)   12/48 (25%)  14/50 (28%) |1/50 (2%)    0/50 (0%)    1/50 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     13/44.15     9/44.18      12/43.41     14/44.44    |1/44.75      0/43.69      1/43.24      3/47.00      | 
|POLY-3 PERCENT (g) |     29.5%        20.4%        27.6%        31.5%       |2.2%         0.0%         2.3%         6.4%         | 
|TERMINAL (d)       |     11/36 (31%)  6/27 (22%)   8/31 (26%)   11/28 (39%) |1/37 (3%)    0/36 (0%)    1/33 (3%)    3/41 (7%)    | 
|FIRST INCIDENCE    |     636          660          675          482         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.163      P=0.463N     P=0.534      P=0.256     |P=0.091      P=0.505N     P=0.736      P=0.342      | 
|POLY 3             |     P=0.258      P=0.228N     P=0.520N     P=0.508     |P=0.079      P=0.505N     P=0.753      P=0.323      | 
|POLY 1.5           |     P=0.257      P=0.224N     P=0.530N     P=0.512     |P=0.076      P=0.503N     P=0.757      P=0.317      | 
|POLY 6             |     P=0.254      P=0.252N     P=0.522N     P=0.484     |P=0.082      P=0.506N     P=0.747      P=0.329      | 
|LOGISTIC REGRESSION|     P=0.238      P=0.271N     P=0.531N     P=0.481     |P=0.091      (e)          P=0.736      P=0.342      | 
|COCH-ARM / FISHERS |     P=0.253      P=0.235N     P=0.547N     P=0.500     |P=0.072      P=0.500N     P=0.753N     P=0.309      | 
|ORDER RESTRICTED   |     P=0.383      (e)          (e)          (e)         |P=0.093      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    0/48 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/43.72      3/44.00      0/42.88      2/43.44     |0/44.75      1/43.69      1/43.24      2/47.38      | 
|POLY-3 PERCENT (g) |     4.6%         6.8%         0.0%         4.6%        |0.0%         2.3%         2.3%         4.2%         | 
|TERMINAL (d)       |     2/36 (6%)    1/27 (4%)    0/31 (0%)    2/28 (7%)   |0/37 (0%)    1/36 (3%)    1/33 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      693          ---          729 (T)     |---          729 (T)      729 (T)      668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.437N     P=0.403      P=0.272N     P=0.602     |P=0.203      P=0.495      P=0.477      P=0.261      | 
|POLY 3             |     P=0.389N     P=0.503      P=0.241N     P=0.692     |P=0.189      P=0.495      P=0.493      P=0.250      | 
|POLY 1.5           |     P=0.390N     P=0.505      P=0.243N     P=0.693N    |P=0.183      P=0.497      P=0.496      P=0.245      | 
|POLY 6             |     P=0.392N     P=0.491      P=0.242N     P=0.683     |P=0.195      P=0.494      P=0.488      P=0.256      | 
|LOGISTIC REGRESSION|     P=0.403N     P=0.476      (e)          P=0.602     |P=0.180      P=0.495      P=0.477      P=0.213      | 
|COCH-ARM / FISHERS |     P=0.391N     P=0.500      P=0.258N     P=0.691N    |P=0.172      P=0.500      P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.334N     (e)          (e)          (e)         |P=0.129      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    3/48 (6%)    5/50 (10%)  |7/50 (14%)   4/50 (8%)    8/50 (16%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     6/43.72      2/43.80      3/43.39      5/43.62     |7/46.54      4/44.28      8/44.08      3/47.00      | 
|POLY-3 PERCENT (g) |     13.7%        4.6%         6.9%         11.5%       |15.0%        9.0%         18.2%        6.4%         | 
|TERMINAL (d)       |     6/36 (17%)   2/27 (7%)    2/31 (7%)    3/28 (11%)  |4/37 (11%)   3/36 (8%)    5/33 (15%)   3/41 (7%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      576          701         |423          541          615          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.394      P=0.241N     P=0.307N     P=0.594     |P=0.226N     P=0.282N     P=0.433      P=0.133N     | 
|POLY 3             |     P=0.465      P=0.131N     P=0.245N     P=0.502N    |P=0.241N     P=0.290N     P=0.454      P=0.153N     | 
|POLY 1.5           |     P=0.463      P=0.130N     P=0.252N     P=0.498N    |P=0.250N     P=0.280N     P=0.474      P=0.155N     | 
|POLY 6             |     P=0.469      P=0.140N     P=0.243N     P=0.515N    |P=0.235N     P=0.300N     P=0.430      P=0.153N     | 
|LOGISTIC REGRESSION|     P=0.453      P=0.241N     P=0.253N     P=0.575N    |P=0.295N     P=0.231N     P=0.519      P=0.215N     | 
|COCH-ARM / FISHERS |     P=0.463      P=0.134N     P=0.264N     P=0.500N    |P=0.269N     P=0.262N     P=0.500      P=0.159N     | 
|ORDER RESTRICTED   |     P=0.257N     (e)          (e)          (e)         |P=0.148N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Focal Histiocytic                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   2/50 (4%)    8/48 (17%)   5/50 (10%)  |20/50 (40%)  19/50 (38%)  16/50 (32%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     6/44.59      2/43.80      8/43.98      5/43.91     |20/46.21     19/46.50     16/45.22     23/48.32     | 
|POLY-3 PERCENT (g) |     13.5%        4.6%         18.2%        11.4%       |43.3%        40.9%        35.4%        47.6%        | 
|TERMINAL (d)       |     4/36 (11%)   2/27 (7%)    4/31 (13%)   4/28 (14%)  |18/37 (49%)  12/36 (33%)  11/33 (33%)  21/41 (51%)  | 
|FIRST INCIDENCE    |     469          729 (T)      576          590         |423          365          547          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.291      P=0.220N     P=0.324      P=0.621     |P=0.456      P=0.539N     P=0.399N     P=0.504      | 
|POLY 3             |     P=0.342      P=0.138N     P=0.375      P=0.511N    |P=0.347      P=0.490N     P=0.287N     P=0.415      | 
|POLY 1.5           |     P=0.342      P=0.134N     P=0.367      P=0.503N    |P=0.330      P=0.500N     P=0.279N     P=0.387      | 
|POLY 6             |     P=0.341      P=0.151N     P=0.379      P=0.529N    |P=0.356      P=0.465N     P=0.296N     P=0.443      | 
|LOGISTIC REGRESSION|     P=0.345      P=0.134N     P=0.352      P=0.500N    |P=0.308      P=0.502N     P=0.279N     P=0.363      | 
|COCH-ARM / FISHERS |     P=0.345      P=0.134N     P=0.355      P=0.500N    |P=0.298      P=0.500N     P=0.266N     P=0.343      | 
|ORDER RESTRICTED   |     P=0.318      (e)          (e)          (e)         |P=0.350      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Regenerative                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.72      0/43.80      0/42.88      0/43.44     |0/44.75      0/43.69      0/43.24      2/47.11      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          703          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.053      (e)          (e)          P=0.257      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.249      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.044 *    (e)          (e)          P=0.245      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.253      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.049 *    (e)          (e)          P=0.247      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.043 *    (e)          (e)          P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.034 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     36/50 (72%)  29/50 (58%)  33/48 (69%)  28/50 (56%) |39/50 (78%)  38/50 (76%)  35/50 (70%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |     36/46.64     29/46.20     33/46.07     28/45.77    |39/48.99     38/47.60     35/47.78     41/49.21     | 
|POLY-3 PERCENT (g) |     77.2%        62.8%        71.6%        61.2%       |79.6%        79.8%        73.3%        83.3%        | 
|TERMINAL (d)       |     29/36 (81%)  21/27 (78%)  24/31 (77%)  20/28 (71%) |30/37 (81%)  29/36 (81%)  25/33 (76%)  35/41 (85%)  | 
|FIRST INCIDENCE    |     381          542          209          443         |423          365          401          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.414N     P=0.548      P=0.489      P=0.459N    |P=0.387N     P=0.568      P=0.533N     P=0.437N     | 
|POLY 3             |     P=0.168N     P=0.087N     P=0.349N     P=0.065N    |P=0.408      P=0.591      P=0.305N     P=0.414      | 
|POLY 1.5           |     P=0.172N     P=0.088N     P=0.383N     P=0.065N    |P=0.391      P=0.569N     P=0.277N     P=0.410      | 
|POLY 6             |     P=0.163N     P=0.103N     P=0.329N     P=0.073N    |P=0.420      P=0.549      P=0.355N     P=0.414      | 
|LOGISTIC REGRESSION|     P=0.175N     P=0.081N     P=0.426N     P=0.063N    |P=0.386      P=0.511N     P=0.244N     P=0.399      | 
|COCH-ARM / FISHERS |     P=0.178N     P=0.104N     P=0.448N     P=0.072N    |P=0.360      P=0.500N     P=0.247N     P=0.402      | 
|ORDER RESTRICTED   |     P=0.061N     (e)          (e)          (e)         |P=0.372      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  11/50 (22%)  3/48 (6%)    8/50 (16%)  |12/50 (24%)  6/50 (12%)   7/50 (14%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     13/43.85     11/44.49     3/42.98      8/43.44     |12/44.75     6/44.28      7/43.24      8/47.14      | 
|POLY-3 PERCENT (g) |     29.7%        24.7%        7.0%         18.4%       |26.8%        13.6%        16.2%        17.0%        | 
|TERMINAL (d)       |     12/36 (33%)  9/27 (33%)   2/31 (7%)    8/28 (29%)  |12/37 (32%)  5/36 (14%)   7/33 (21%)   7/41 (17%)   | 
|FIRST INCIDENCE    |     695          605          703          729 (T)     |729 (T)      541          729 (T)      693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.106N     P=0.496      P=0.015N*    P=0.353N    |P=0.274N     P=0.104N     P=0.218N     P=0.154N     | 
|POLY 3             |     P=0.066N     P=0.389N     P=0.006N**   P=0.162N    |P=0.313N     P=0.096N     P=0.169N     P=0.186N     | 
|POLY 1.5           |     P=0.067N     P=0.389N     P=0.006N**   P=0.159N    |P=0.329N     P=0.096N     P=0.161N     P=0.201N     | 
|POLY 6             |     P=0.066N     P=0.413N     P=0.006N**   P=0.178N    |P=0.299N     P=0.094N     P=0.185N     P=0.172N     | 
|LOGISTIC REGRESSION|     P=0.074N     P=0.464N     P=0.009N**   P=0.277N    |P=0.293N     P=0.106N     P=0.218N     P=0.173N     | 
|COCH-ARM / FISHERS |     P=0.070N     P=0.408N     P=0.008N**   P=0.163N    |P=0.358N     P=0.096N     P=0.154N     P=0.227N     | 
|ORDER RESTRICTED   |     P=0.030N*    (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     48/50 (96%)  49/50 (98%)  46/48 (96%)  50/50 (100%)|29/50 (58%)  24/50 (48%)  34/50 (68%)  26/50 (52%)  | 
|POLY-3 RATE (b)    |     48/48.47     49/49.88     46/47.02     50/50.00    |29/46.88     24/46.28     34/47.15     26/48.71     | 
|POLY-3 PERCENT (g) |     99.0%        98.2%        97.8%        100.0%      |61.9%        51.9%        72.1%        53.4%        | 
|TERMINAL (d)       |     36/36 (100%) 27/27 (100%) 30/31 (97%)  28/28 (100%)|22/37 (60%)  16/36 (44%)  23/33 (70%)  20/41 (49%)  | 
|FIRST INCIDENCE    |     423          542          561          443         |566          563          511          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.180      P=0.050      P=0.339      P=0.050     |P=0.376N     P=0.285N     P=0.113      P=0.208N     | 
|POLY 3             |     P=0.417      P=0.738N     P=0.655N     P=0.926     |P=0.460N     P=0.220N     P=0.196      P=0.263N     | 
|POLY 1.5           |     P=0.312      P=0.797      P=0.732N     P=0.523     |P=0.502N     P=0.220N     P=0.200      P=0.291N     | 
|POLY 6             |     P=0.535      P=0.679N     P=0.545N     P=1.000     |P=0.435N     P=0.213N     P=0.187      P=0.240N     | 
|LOGISTIC REGRESSION|     P=0.220      P=0.718N     P=0.616N     P=0.398     |P=0.524N     P=0.232N     P=0.175      P=0.297N     | 
|COCH-ARM / FISHERS |     P=0.238      P=0.500      P=0.676N     P=0.247     |P=0.484      P=0.212N     P=0.204      P=0.344N     | 
|ORDER RESTRICTED   |     P=0.325      (e)          (e)          (e)         |P=0.299N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/48 (0%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.72      1/44.05      0/42.88      2/44.33     |0/44.75      2/44.48      0/43.24      1/47.11      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         0.0%         4.5%        |0.0%         4.5%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          663          ---          545         |---          433          ---          703          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.184      P=0.495      (e)          P=0.253     |P=0.597N     P=0.234      (e)          P=0.510      | 
|POLY 3             |     P=0.179      P=0.501      (e)          P=0.240     |P=0.616N     P=0.236      (e)          P=0.510      | 
|POLY 1.5           |     P=0.178      P=0.502      (e)          P=0.240     |P=0.616N     P=0.236      (e)          P=0.506      | 
|POLY 6             |     P=0.177      P=0.496      (e)          P=0.237     |P=0.617N     P=0.235      (e)          P=0.514      | 
|LOGISTIC REGRESSION|     P=0.175      P=0.486      (e)          P=0.200     |P=0.601      P=0.279      (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.176      P=0.500      (e)          P=0.247     |P=0.616N     P=0.247      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.076      (e)          (e)          (e)         |P=0.317      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      0/43.80      0/42.88      0/43.44     |0/44.75      0/43.69      2/44.06      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          587          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.541      (e)          P=0.234      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.560      (e)          P=0.234      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.546      (e)          P=0.235      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.573      (e)          P=0.230      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.444      (e)          P=0.247      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.522      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.244      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic Diffuse                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    0/48 (0%)    4/50 (8%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/44.67      3/44.32      0/42.88      4/43.80     |1/45.00      2/43.96      1/43.61      2/47.65      | 
|POLY-3 PERCENT (g) |     6.7%         6.8%         0.0%         9.1%        |2.2%         4.6%         2.3%         4.2%         | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    0/31 (0%)    1/28 (4%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     381          663          ---          681         |661          657          626          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.455      P=0.609      P=0.141N     P=0.421     |P=0.529      P=0.482      P=0.746      P=0.537      | 
|POLY 3             |     P=0.482      P=0.659      P=0.126N     P=0.489     |P=0.511      P=0.492      P=0.754      P=0.520      | 
|POLY 1.5           |     P=0.483      P=0.662N     P=0.126N     P=0.495     |P=0.502      P=0.494      P=0.757      P=0.512      | 
|POLY 6             |     P=0.479      P=0.647      P=0.128N     P=0.477     |P=0.520      P=0.490      P=0.748      P=0.528      | 
|LOGISTIC REGRESSION|     P=0.487      P=0.604      P=0.124N     P=0.490     |P=0.432      P=0.504      P=0.754N     P=0.411      | 
|COCH-ARM / FISHERS |     P=0.486      P=0.661N     P=0.129N     P=0.500     |P=0.487      P=0.500      P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.278      (e)          (e)          (e)         |P=0.468      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic Focal                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     26/50 (52%)  15/50 (30%)  14/48 (29%)  18/50 (36%) |17/50 (34%)  10/50 (20%)  10/50 (20%)  10/50 (20%)  | 
|POLY-3 RATE (b)    |     26/44.17     15/43.81     14/43.39     18/44.52    |17/46.12     10/44.93     10/43.94     10/47.11     | 
|POLY-3 PERCENT (g) |     58.9%        34.2%        32.3%        40.4%       |36.9%        22.3%        22.8%        21.2%        | 
|TERMINAL (d)       |     24/36 (67%)  14/27 (52%)  13/31 (42%)  16/28 (57%) |14/37 (38%)  7/36 (19%)   7/33 (21%)   9/41 (22%)   | 
|FIRST INCIDENCE    |     630          726          576          443         |423          541          587          703          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.346N     P=0.153N     P=0.033N*    P=0.326N    |P=0.106N     P=0.110N     P=0.157N     P=0.054N     | 
|POLY 3             |     P=0.169N     P=0.014N*    P=0.008N**   P=0.057N    |P=0.126N     P=0.095N     P=0.107N     P=0.073N     | 
|POLY 1.5           |     P=0.183N     P=0.014N*    P=0.011N*    P=0.061N    |P=0.134N     P=0.094N     P=0.098N     P=0.079N     | 
|POLY 6             |     P=0.155N     P=0.018N*    P=0.008N**   P=0.063N    |P=0.122N     P=0.093N     P=0.120N     P=0.068N     | 
|LOGISTIC REGRESSION|     P=0.214N     P=0.042N*    P=0.012N*    P=0.083N    |P=0.126N     P=0.092N     P=0.098N     P=0.074N     | 
|COCH-ARM / FISHERS |     P=0.206N     P=0.021N*    P=0.018N*    P=0.079N    |P=0.151N     P=0.088N     P=0.088N     P=0.088N     | 
|ORDER RESTRICTED   |     P=0.014N*    (e)          (e)          (e)         |P=0.057N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Centrilobular                                                                                                 | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    6/48 (13%)   4/50 (8%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.39      3/44.91      6/44.59      4/44.35     |2/45.68      1/44.02      1/43.76      2/47.57      | 
|POLY-3 PERCENT (g) |     2.3%         6.7%         13.5%        9.0%        |4.4%         2.3%         2.3%         4.2%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     503          562          561          562         |555          639          573          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.151      P=0.317      P=0.064      P=0.169     |P=0.546      P=0.505N     P=0.505N     P=0.659N     | 
|POLY 3             |     P=0.150      P=0.309      P=0.056      P=0.178     |P=0.536      P=0.513N     P=0.515N     P=0.679N     | 
|POLY 1.5           |     P=0.152      P=0.311      P=0.053      P=0.180     |P=0.527      P=0.508N     P=0.508N     P=0.684N     | 
|POLY 6             |     P=0.146      P=0.301      P=0.058      P=0.173     |P=0.543      P=0.518N     P=0.526N     P=0.674N     | 
|LOGISTIC REGRESSION|     P=0.150      P=0.145      P=0.043 *    P=0.156     |P=0.384      P=0.445N     P=0.479N     P=0.563      | 
|COCH-ARM / FISHERS |     P=0.154      P=0.309      P=0.050      P=0.181     |P=0.513      P=0.500N     P=0.500N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.087      (e)          (e)          (e)         |P=0.549N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Centrilobular                                                                                                 | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    9/50 (18%)   12/48 (25%)  11/50 (22%) |5/50 (10%)   3/50 (6%)    8/50 (16%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     4/45.88      9/46.46      12/45.07     11/44.79    |5/46.13      3/44.02      8/45.40      3/47.46      | 
|POLY-3 PERCENT (g) |     8.7%         19.4%        26.6%        24.6%       |10.8%        6.8%         17.6%        6.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    3/31 (10%)   4/28 (14%)  |0/37 (0%)    2/36 (6%)    1/33 (3%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     469          562          561          562         |594          639          573          668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.069      P=0.128      P=0.034 *    P=0.040 *   |P=0.445N     P=0.376N     P=0.248      P=0.319N     | 
|POLY 3             |     P=0.053      P=0.120      P=0.022 *    P=0.038 *   |P=0.456N     P=0.382N     P=0.265      P=0.341N     | 
|POLY 1.5           |     P=0.058      P=0.121      P=0.022 *    P=0.041 *   |P=0.472N     P=0.373N     P=0.270      P=0.346N     | 
|POLY 6             |     P=0.047 *    P=0.113      P=0.023 *    P=0.033 *   |P=0.442N     P=0.394N     P=0.257      P=0.339N     | 
|LOGISTIC REGRESSION|     P=0.064      P=0.041 *    P=0.016 *    P=0.040 *   |P=0.539      P=0.337N     P=0.300      P=0.447N     | 
|COCH-ARM / FISHERS |     P=0.066      P=0.117      P=0.022 *    P=0.045 *   |P=0.504N     P=0.357N     P=0.277      P=0.357N     | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |P=0.299N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Midzonal                                                                                                      | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   1/50 (2%)    0/48 (0%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     6/45.11      1/43.92      0/42.88      1/43.63     |0/44.75      2/44.48      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     13.3%        2.3%         0.0%         2.3%        |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/36 (6%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     423          699          ---          678         |---          433          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.060N     P=0.090N     P=0.026N*    P=0.082N    |P=0.230N     P=0.234      (e)          (e)          | 
|POLY 3             |     P=0.048N*    P=0.060N     P=0.018N*    P=0.061N    |P=0.236N     P=0.236      (e)          (e)          | 
|POLY 1.5           |     P=0.049N*    P=0.057N     P=0.018N*    P=0.058N    |P=0.235N     P=0.236      (e)          (e)          | 
|POLY 6             |     P=0.045N*    P=0.067N     P=0.019N*    P=0.067N    |P=0.236N     P=0.235      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.052N     P=0.068N     P=0.020N*    P=0.061N    |P=0.298N     P=0.279      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.053N     P=0.056N     P=0.015N*    P=0.056N    |P=0.236N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.003N**   (e)          (e)          (e)         |P=0.237N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte, Periportal                                                                                                    | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/48 (2%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      1/43.94      1/43.14      0/43.44     |0/44.75      2/45.15      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.3%         0.0%        |0.0%         4.4%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          693          660          ---         |---          423          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.528N     P=0.479      P=0.505      (e)         |P=0.234N     P=0.235      (e)          (e)          | 
|POLY 3             |     P=0.524N     P=0.501      P=0.497      (e)         |P=0.233N     P=0.239      (e)          (e)          | 
|POLY 1.5           |     P=0.522N     P=0.502      P=0.495      (e)         |P=0.234N     P=0.238      (e)          (e)          | 
|POLY 6             |     P=0.529N     P=0.495      P=0.497      (e)         |P=0.234N     P=0.240      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.523N     P=0.501      P=0.489      (e)         |P=0.409N     P=0.356      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.524N     P=0.500      P=0.490      (e)         |P=0.236N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.399      (e)          (e)          (e)         |P=0.240N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Congestion                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.18      1/44.08      3/44.90      0/43.44     |0/44.75      0/43.69      2/44.47      1/47.14      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         6.7%         0.0%        |0.0%         0.0%         4.5%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     423          652          566          ---         |---          ---          514          693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.294N     P=0.485N     P=0.509      P=0.235N    |P=0.217      (e)          P=0.242      P=0.514      | 
|POLY 3             |     P=0.302N     P=0.509N     P=0.497      P=0.246N    |P=0.226      (e)          P=0.236      P=0.510      | 
|POLY 1.5           |     P=0.298N     P=0.503N     P=0.498      P=0.242N    |P=0.216      (e)          P=0.237      P=0.506      | 
|POLY 6             |     P=0.308N     P=0.521N     P=0.493      P=0.254N    |P=0.235      (e)          P=0.232      P=0.514      | 
|LOGISTIC REGRESSION|     P=0.274N     P=0.721      P=0.509      P=0.356N    |P=0.095      (e)          P=0.233      P=0.492      | 
|COCH-ARM / FISHERS |     P=0.292N     P=0.500N     P=0.500      P=0.247N    |P=0.201      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.191N     (e)          (e)          (e)         |P=0.167      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    2/50 (4%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/43.72      1/43.80      2/43.73      2/43.76     |1/44.79      0/43.69      1/43.24      2/47.37      | 
|POLY-3 PERCENT (g) |     6.9%         2.3%         4.6%         4.6%        |2.2%         0.0%         2.3%         4.2%         | 
|TERMINAL (d)       |     3/36 (8%)    1/27 (4%)    2/31 (7%)    1/28 (4%)   |0/37 (0%)    0/36 (0%)    1/33 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      639         |717          ---          729 (T)      670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.567      P=0.412N     P=0.569N     P=0.582N    |P=0.220      P=0.516N     P=0.726      P=0.522      | 
|POLY 3             |     P=0.567N     P=0.304N     P=0.500N     P=0.500N    |P=0.213      P=0.505N     P=0.753      P=0.519      | 
|POLY 1.5           |     P=0.568N     P=0.302N     P=0.499N     P=0.498N    |P=0.206      P=0.503N     P=0.757      P=0.512      | 
|POLY 6             |     P=0.565N     P=0.315N     P=0.507N     P=0.508N    |P=0.220      P=0.507N     P=0.746      P=0.527      | 
|LOGISTIC REGRESSION|     P=0.578N     P=0.412N     P=0.569N     P=0.507N    |P=0.199      P=0.506N     P=0.744      P=0.486      | 
|COCH-ARM / FISHERS |     P=0.567N     P=0.309N     P=0.500N     P=0.500N    |P=0.193      P=0.500N     P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.394N     (e)          (e)          (e)         |P=0.247      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |4/50 (8%)    6/50 (12%)   5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/45.11      1/44.39      1/44.46      2/44.76     |4/47.30      6/47.95      5/46.34      2/48.32      | 
|POLY-3 PERCENT (g) |     4.4%         2.3%         2.3%         4.5%        |8.5%         12.5%        10.8%        4.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     469          542          475          443         |423          365          401          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.512      P=0.474N     P=0.488N     P=0.682N    |P=0.164N     P=0.362      P=0.501      P=0.329N     | 
|POLY 3             |     P=0.513      P=0.506N     P=0.505N     P=0.691     |P=0.163N     P=0.378      P=0.487      P=0.328N     | 
|POLY 1.5           |     P=0.513      P=0.501N     P=0.503N     P=0.694N    |P=0.166N     P=0.376      P=0.494      P=0.331N     | 
|POLY 6             |     P=0.513      P=0.518N     P=0.512N     P=0.683     |P=0.162N     P=0.379      P=0.475      P=0.325N     | 
|LOGISTIC REGRESSION|     P=0.515      P=0.663      P=0.458N     P=0.560     |P=0.567      P=0.474      P=0.561      P=0.685      | 
|COCH-ARM / FISHERS |     P=0.513      P=0.500N     P=0.500N     P=0.691N    |P=0.169N     P=0.370      P=0.500      P=0.339N     | 
|ORDER RESTRICTED   |     P=0.547      (e)          (e)          (e)         |P=0.211N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Focal Histiocytic                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.72      1/44.23      1/43.73      0/43.44     |1/45.49      1/43.69      0/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         2.3%         0.0%        |2.2%         2.3%         0.0%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/31 (3%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     ---          605          729 (T)      ---         |462          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.536N     P=0.509      P=0.470      (e)         |P=0.405      P=0.753      P=0.500N     P=0.526      | 
|POLY 3             |     P=0.523N     P=0.502      P=0.500      (e)         |P=0.386      P=0.752      P=0.510N     P=0.511      | 
|POLY 1.5           |     P=0.522N     P=0.503      P=0.500      (e)         |P=0.383      P=0.755      P=0.506N     P=0.507      | 
|POLY 6             |     P=0.530N     P=0.497      P=0.497      (e)         |P=0.389      P=0.749      P=0.517N     P=0.515      | 
|LOGISTIC REGRESSION|     P=0.521N     P=0.425      P=0.470      (e)         |P=0.335      P=0.728N     P=0.483N     P=0.400      | 
|COCH-ARM / FISHERS |     P=0.522N     P=0.500      P=0.500      (e)         |P=0.376      P=0.753N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.401      (e)          (e)          (e)         |P=0.291      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |2/50 (4%)    3/50 (6%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.52      3/43.80      1/44.16      2/43.56     |2/45.35      3/43.69      2/43.76      1/47.23      | 
|POLY-3 PERCENT (g) |     2.3%         6.9%         2.3%         4.6%        |4.4%         6.9%         4.6%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    3/27 (11%)   0/31 (0%)    1/28 (4%)   |0/37 (0%)    3/36 (8%)    1/33 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     423          729 (T)      607          699         |555          729 (T)      573          670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.581      P=0.235      P=0.758N     P=0.464     |P=0.246N     P=0.484      P=0.667      P=0.481N     | 
|POLY 3             |     P=0.583N     P=0.299      P=0.759      P=0.492     |P=0.253N     P=0.483      P=0.681      P=0.486N     | 
|POLY 1.5           |     P=0.580N     P=0.304      P=0.759      P=0.497     |P=0.259N     P=0.489      P=0.687      P=0.491N     | 
|POLY 6             |     P=0.591N     P=0.286      P=0.756      P=0.483     |P=0.248N     P=0.476      P=0.671      P=0.481N     | 
|LOGISTIC REGRESSION|     P=0.575N     P=0.264      P=0.740N     P=0.467     |P=0.286N     P=0.500      P=0.681N     P=0.587N     | 
|COCH-ARM / FISHERS |     P=0.577N     P=0.309      P=0.753N     P=0.500     |P=0.268N     P=0.500      P=0.691N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.454      (e)          (e)          (e)         |P=0.325N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    3/50 (6%)    3/50 (6%)   |2/50 (4%)    0/50 (0%)    4/50 (8%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/43.84      2/43.81      3/43.94      3/43.60     |2/45.00      0/43.69      4/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     11.4%        4.6%         6.8%         6.9%        |4.4%         0.0%         9.3%         4.3%         | 
|TERMINAL (d)       |     4/36 (11%)   1/27 (4%)    2/31 (7%)    1/28 (4%)   |1/37 (3%)    0/36 (0%)    4/33 (12%)   2/41 (5%)    | 
|FIRST INCIDENCE    |     699          726          675          699         |661          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.501N     P=0.335N     P=0.432N     P=0.470N    |P=0.333      P=0.251N     P=0.288      P=0.657N     | 
|POLY 3             |     P=0.444N     P=0.216N     P=0.355N     P=0.359N    |P=0.324      P=0.244N     P=0.319      P=0.678N     | 
|POLY 1.5           |     P=0.445N     P=0.213N     P=0.355N     P=0.355N    |P=0.311      P=0.242N     P=0.328      P=0.684N     | 
|POLY 6             |     P=0.443N     P=0.229N     P=0.362N     P=0.371N    |P=0.336      P=0.246N     P=0.304      P=0.674N     | 
|LOGISTIC REGRESSION|     P=0.458N     P=0.259N     P=0.367N     P=0.384N    |P=0.318      P=0.238N     P=0.307      P=0.684N     | 
|COCH-ARM / FISHERS |     P=0.442N     P=0.218N     P=0.357N     P=0.357N    |P=0.287      P=0.247N     P=0.339      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.274N     (e)          (e)          (e)         |P=0.238      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/50 (10%)   3/50 (6%)    4/50 (8%)   |4/50 (8%)    2/50 (4%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     8/44.07      5/44.19      3/43.73      4/43.77     |4/44.75      2/43.69      3/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     18.2%        11.3%        6.9%         9.1%        |8.9%         4.6%         6.9%         4.3%         | 
|TERMINAL (d)       |     7/36 (19%)   3/27 (11%)   3/31 (10%)   2/28 (7%)   |4/37 (11%)   2/36 (6%)    3/33 (9%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     630          638          729 (T)      672         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.198N     P=0.438N     P=0.148N     P=0.288N    |P=0.326N     P=0.349N     P=0.563N     P=0.290N     | 
|POLY 3             |     P=0.153N     P=0.272N     P=0.099N     P=0.178N    |P=0.344N     P=0.348N     P=0.519N     P=0.315N     | 
|POLY 1.5           |     P=0.153N     P=0.269N     P=0.099N     P=0.176N    |P=0.354N     P=0.345N     P=0.510N     P=0.323N     | 
|POLY 6             |     P=0.154N     P=0.291N     P=0.105N     P=0.188N    |P=0.334N     P=0.351N     P=0.534N     P=0.307N     | 
|LOGISTIC REGRESSION|     P=0.157N     P=0.286N     P=0.106N     P=0.186N    |P=0.326N     P=0.349N     P=0.563N     P=0.290N     | 
|COCH-ARM / FISHERS |     P=0.152N     P=0.277N     P=0.100N     P=0.178N    |P=0.372N     P=0.339N     P=0.500N     P=0.339N     | 
|ORDER RESTRICTED   |     P=0.101N     (e)          (e)          (e)         |P=0.275N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    1/49 (2%)    3/50 (6%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.39      1/44.06      1/42.87      3/43.54     |0/44.75      0/43.02      0/42.64      0/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         2.3%         6.9%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    0/30 (0%)    2/28 (7%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      660          695          703         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.139      P=0.729      P=0.731      P=0.231     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.158      P=0.757N     P=0.758      P=0.306     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.160      P=0.755N     P=0.759      P=0.311     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.155      P=0.757      P=0.754      P=0.296     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.157      P=0.758N     P=0.758      P=0.276     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.161      P=0.747N     P=0.753N     P=0.316     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.188      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    3/49 (6%)    0/50 (0%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.39      2/44.57      3/43.05      0/43.44     |0/44.75      0/43.02      0/42.64      1/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         7.0%         0.0%        |0.0%         0.0%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/30 (3%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     ---          574          660          ---         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.483N     P=0.247      P=0.110      (e)         |P=0.203      (e)          (e)          P=0.520      | 
|POLY 3             |     P=0.472N     P=0.243      P=0.117      (e)         |P=0.195      (e)          (e)          P=0.510      | 
|POLY 1.5           |     P=0.466N     P=0.244      P=0.118      (e)         |P=0.192      (e)          (e)          P=0.506      | 
|POLY 6             |     P=0.486N     P=0.237      P=0.114      (e)         |P=0.198      (e)          (e)          P=0.513      | 
|LOGISTIC REGRESSION|     P=0.457N     P=0.174      P=0.119      (e)         |(e)          (e)          (e)          P=0.520      | 
|COCH-ARM / FISHERS |     P=0.462N     P=0.253      P=0.121      (e)         |P=0.186      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.224N     (e)          (e)          (e)         |P=0.130      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    3/50 (6%)    0/49 (0%)    1/50 (2%)   |2/50 (4%)    4/49 (8%)    0/49 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     3/44.12      3/45.18      0/42.73      1/43.73     |2/44.75      4/43.61      0/42.64      4/47.11      | 
|POLY-3 PERCENT (g) |     6.8%         6.6%         0.0%         2.3%        |4.5%         9.2%         0.0%         8.5%         | 
|TERMINAL (d)       |     2/36 (6%)    0/27 (0%)    0/30 (0%)    0/28 (0%)   |2/37 (5%)    3/36 (8%)    0/33 (0%)    3/41 (7%)    | 
|FIRST INCIDENCE    |     469          542          ---          651         |729 (T)      541          ---          703          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.116N     P=0.631      P=0.144N     P=0.348N    |P=0.516      P=0.326      P=0.264N     P=0.382      | 
|POLY 3             |     P=0.110N     P=0.652N     P=0.124N     P=0.308N    |P=0.488      P=0.325      P=0.248N     P=0.361      | 
|POLY 1.5           |     P=0.108N     P=0.649N     P=0.122N     P=0.303N    |P=0.482      P=0.325      P=0.245N     P=0.352      | 
|POLY 6             |     P=0.113N     P=0.663N     P=0.129N     P=0.319N    |P=0.492      P=0.327      P=0.253N     P=0.370      | 
|LOGISTIC REGRESSION|     P=0.093N     P=0.565      P=0.113N     P=0.304N    |P=0.492      P=0.324      (e)          P=0.369      | 
|COCH-ARM / FISHERS |     P=0.106N     P=0.651N     P=0.121N     P=0.301N    |P=0.473      P=0.329      P=0.253N     P=0.339      | 
|ORDER RESTRICTED   |     P=0.136N     (e)          (e)          (e)         |P=0.312      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    1/50 (2%)    0/49 (0%)    1/50 (2%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.12      1/44.36      0/42.73      1/43.51     |1/44.75      0/43.02      0/42.64      0/47.00      | 
|POLY-3 PERCENT (g) |     4.5%         2.3%         0.0%         2.3%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    0/30 (0%)    0/28 (0%)   |1/37 (3%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     469          555          ---          710         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.396N     P=0.516N     P=0.257N     P=0.546N    |P=0.352N     P=0.505N     P=0.523N     P=0.480N     | 
|POLY 3             |     P=0.379N     P=0.498N     P=0.244N     P=0.505N    |P=0.364N     P=0.508N     P=0.510N     P=0.490N     | 
|POLY 1.5           |     P=0.378N     P=0.493N     P=0.241N     P=0.499N    |P=0.363N     P=0.507N     P=0.507N     P=0.494N     | 
|POLY 6             |     P=0.379N     P=0.510N     P=0.250N     P=0.516N    |P=0.366N     P=0.508N     P=0.514N     P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.358N     P=0.654N     P=0.214N     P=0.505N    |P=0.352N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.374N     P=0.492N     P=0.247N     P=0.492N    |P=0.362N     P=0.505N     P=0.505N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.232N     (e)          (e)          (e)         |P=0.111N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/34 (15%)   7/24 (29%)   5/26 (19%)   3/34 (9%)   |2/36 (6%)    4/34 (12%)   2/30 (7%)    4/39 (10%)   | 
|POLY-3 RATE (b)    |     5/29.59      7/21.25      5/22.73      3/29.34     |2/32.62      4/29.78      2/24.90      4/36.23      | 
|POLY-3 PERCENT (g) |     16.9%        32.9%        22.0%        10.2%       |6.1%         13.4%        8.0%         11.0%        | 
|TERMINAL (d)       |     4/23 (17%)   4/12 (33%)   2/13 (15%)   1/16 (6%)   |2/27 (7%)    4/24 (17%)   2/17 (12%)   3/30 (10%)   | 
|FIRST INCIDENCE    |     706          663          660          681         |729 (T)      729 (T)      729 (T)      668          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.235N     P=0.117      P=0.396      P=0.515N    |P=0.472      P=0.280      P=0.519      P=0.388      | 
|POLY 3             |     P=0.115N     P=0.158      P=0.456      P=0.357N    |P=0.471      P=0.293      P=0.594      P=0.386      | 
|POLY 1.5           |     P=0.115N     P=0.158      P=0.451      P=0.355N    |P=0.466      P=0.299      P=0.610      P=0.382      | 
|POLY 6             |     P=0.121N     P=0.154      P=0.458      P=0.367N    |P=0.472      P=0.287      P=0.568      P=0.387      | 
|LOGISTIC REGRESSION|     P=0.125N     P=0.137      P=0.433      P=0.388N    |P=0.461      P=0.280      P=0.519      P=0.381      | 
|COCH-ARM / FISHERS |     P=0.117N     P=0.156      P=0.450      P=0.355N    |P=0.455      P=0.309      P=0.621      P=0.376      | 
|ORDER RESTRICTED   |     P=0.124N     (e)          (e)          (e)         |P=0.375      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/34 (9%)    2/24 (8%)    2/26 (8%)    1/34 (3%)   |6/36 (17%)   6/34 (18%)   5/30 (17%)   3/39 (8%)    | 
|POLY-3 RATE (b)    |     3/29.59      2/20.94      2/22.44      1/29.29     |6/32.66      6/31.23      5/26.28      3/36.00      | 
|POLY-3 PERCENT (g) |     10.1%        9.6%         8.9%         3.4%        |18.4%        19.2%        19.0%        8.3%         | 
|TERMINAL (d)       |     2/23 (9%)    1/12 (8%)    1/13 (8%)    0/16 (0%)   |5/27 (19%)   3/24 (13%)   1/17 (6%)    3/30 (10%)   | 
|FIRST INCIDENCE    |     706          693          647          672         |717          433          573          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.292N     P=0.669      P=0.657N     P=0.392N    |P=0.138N     P=0.555      P=0.556      P=0.195N     | 
|POLY 3             |     P=0.217N     P=0.657N     P=0.626N     P=0.307N    |P=0.123N     P=0.592      P=0.606      P=0.191N     | 
|POLY 1.5           |     P=0.216N     P=0.655N     P=0.627N     P=0.305N    |P=0.125N     P=0.588      P=0.618      P=0.194N     | 
|POLY 6             |     P=0.221N     P=0.664N     P=0.631N     P=0.314N    |P=0.125N     P=0.594      P=0.587      P=0.192N     | 
|LOGISTIC REGRESSION|     P=0.218N     P=0.674N     P=0.635N     P=0.312N    |P=0.135N     P=0.592      P=0.625      P=0.206N     | 
|COCH-ARM / FISHERS |     P=0.212N     P=0.696      P=0.628N     P=0.307N    |P=0.128N     P=0.581      P=0.627      P=0.201N     | 
|ORDER RESTRICTED   |     P=0.242N     (e)          (e)          (e)         |P=0.166N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/34 (3%)    3/24 (13%)   4/26 (15%)   1/34 (3%)   |1/36 (3%)    4/34 (12%)   2/30 (7%)    3/39 (8%)    | 
|POLY-3 RATE (b)    |     1/29.50      3/20.94      4/22.56      1/29.07     |1/32.99      4/29.79      2/24.90      3/36.00      | 
|POLY-3 PERCENT (g) |     3.4%         14.3%        17.7%        3.4%        |3.0%         13.4%        8.0%         8.3%         | 
|TERMINAL (d)       |     1/23 (4%)    2/12 (17%)   3/13 (23%)   1/16 (6%)   |0/27 (0%)    3/24 (13%)   2/17 (12%)   3/30 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      693          607          729 (T)     |623          727          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.540N     P=0.145      P=0.069      P=0.680     |P=0.522      P=0.161      P=0.386      P=0.345      | 
|POLY 3             |     P=0.423N     P=0.186      P=0.100      P=0.758     |P=0.516      P=0.146      P=0.402      P=0.336      | 
|POLY 1.5           |     P=0.417N     P=0.188      P=0.100      P=0.760     |P=0.516      P=0.151      P=0.418      P=0.336      | 
|POLY 6             |     P=0.438N     P=0.182      P=0.098      P=0.753     |P=0.509      P=0.139      P=0.378      P=0.332      | 
|LOGISTIC REGRESSION|     P=0.431N     P=0.172      P=0.099      P=0.680     |P=0.523      P=0.153      P=0.428      P=0.333      | 
|COCH-ARM / FISHERS |     P=0.414N     P=0.187      P=0.105      P=0.754N    |P=0.512      P=0.161      P=0.431      P=0.338      | 
|ORDER RESTRICTED   |     P=0.209      (e)          (e)          (e)         |P=0.211      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/34 (3%)    0/24 (0%)    1/26 (4%)    3/34 (9%)   |1/36 (3%)    2/34 (6%)    2/30 (7%)    3/39 (8%)    | 
|POLY-3 RATE (b)    |     1/29.50      0/20.80      1/22.13      3/29.07     |1/32.62      2/29.78      2/25.38      3/36.00      | 
|POLY-3 PERCENT (g) |     3.4%         0.0%         4.5%         10.3%       |3.1%         6.7%         7.9%         8.3%         | 
|TERMINAL (d)       |     1/23 (4%)    0/12 (0%)    1/13 (8%)    3/16 (19%)  |1/27 (4%)    2/24 (8%)    1/17 (6%)    3/30 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |729 (T)      729 (T)      587          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.054      P=0.630N     P=0.630      P=0.181     |P=0.300      P=0.459      P=0.394      P=0.342      | 
|POLY 3             |     P=0.093      P=0.570N     P=0.696      P=0.298     |P=0.300      P=0.468      P=0.413      P=0.340      | 
|POLY 1.5           |     P=0.095      P=0.569N     P=0.696      P=0.302     |P=0.296      P=0.473      P=0.424      P=0.339      | 
|POLY 6             |     P=0.090      P=0.573N     P=0.692      P=0.288     |P=0.300      P=0.463      P=0.395      P=0.340      | 
|LOGISTIC REGRESSION|     P=0.054      (e)          P=0.630      P=0.181     |P=0.297      P=0.459      P=0.445      P=0.342      | 
|COCH-ARM / FISHERS |     P=0.096      P=0.586N     P=0.683      P=0.307     |P=0.286      P=0.478      P=0.431      P=0.338      | 
|ORDER RESTRICTED   |     P=0.086      (e)          (e)          (e)         |P=0.282      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/34 (6%)    0/24 (0%)    0/26 (0%)    0/34 (0%)   |0/36 (0%)    1/34 (3%)    0/30 (0%)    0/39 (0%)    | 
|POLY-3 RATE (b)    |     2/30.89      0/20.80      0/22.13      0/29.07     |0/32.62      1/30.44      0/24.90      0/36.00      | 
|POLY-3 PERCENT (g) |     6.5%         0.0%         0.0%         0.0%        |0.0%         3.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/23 (0%)    0/12 (0%)    0/13 (0%)    0/16 (0%)   |0/27 (0%)    0/24 (0%)    0/17 (0%)    0/30 (0%)    | 
|FIRST INCIDENCE    |     469          ---          ---          ---         |---          511          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.176N     P=0.226N     P=0.235N     P=0.237N    |P=0.418N     P=0.496      (e)          (e)          | 
|POLY 3             |     P=0.161N     P=0.328N     P=0.314N     P=0.250N    |P=0.421N     P=0.486      (e)          (e)          | 
|POLY 1.5           |     P=0.163N     P=0.323N     P=0.309N     P=0.244N    |P=0.418N     P=0.487      (e)          (e)          | 
|POLY 6             |     P=0.159N     P=0.338N     P=0.323N     P=0.259N    |P=0.427N     P=0.485      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.107N     P=0.996N     P=0.144N     P=0.185N    |P=0.559N     P=0.569      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.165N     P=0.339N     P=0.317N     P=0.246N    |P=0.413N     P=0.486      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.033N*    (e)          (e)          (e)         |P=0.352N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/34 (9%)    3/24 (13%)   3/26 (12%)   6/34 (18%)  |1/36 (3%)    0/34 (0%)    0/30 (0%)    1/39 (3%)    | 
|POLY-3 RATE (b)    |     3/29.50      3/20.86      3/22.24      6/29.81     |1/32.62      0/29.78      0/24.90      1/36.00      | 
|POLY-3 PERCENT (g) |     10.2%        14.4%        13.5%        20.1%       |3.1%         0.0%         0.0%         2.8%         | 
|TERMINAL (d)       |     3/23 (13%)   2/12 (17%)   2/13 (15%)   2/16 (13%)  |1/27 (4%)    0/24 (0%)    0/17 (0%)    1/30 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      714          703          651         |729 (T)      ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.109      P=0.389      P=0.424      P=0.151     |P=0.544      P=0.523N     P=0.592N     P=0.739N     | 
|POLY 3             |     P=0.203      P=0.495      P=0.527      P=0.240     |P=0.549      P=0.518N     P=0.554N     P=0.739N     | 
|POLY 1.5           |     P=0.202      P=0.497      P=0.528      P=0.240     |P=0.546      P=0.516N     P=0.545N     P=0.740N     | 
|POLY 6             |     P=0.202      P=0.487      P=0.521      P=0.238     |P=0.551      P=0.521N     P=0.566N     P=0.739N     | 
|LOGISTIC REGRESSION|     P=0.179      P=0.433      P=0.462      P=0.224     |P=0.544      (e)          (e)          P=0.739N     | 
|COCH-ARM / FISHERS |     P=0.200      P=0.486      P=0.528      P=0.238     |P=0.539      P=0.514N     P=0.545N     P=0.733N     | 
|ORDER RESTRICTED   |     P=0.190      (e)          (e)          (e)         |P=0.398N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/34 (15%)   3/24 (13%)   1/26 (4%)    1/34 (3%)   |5/36 (14%)   3/34 (9%)    0/30 (0%)    5/39 (13%)   | 
|POLY-3 RATE (b)    |     5/30.68      3/21.57      1/22.68      1/29.07     |5/32.62      3/30.44      0/24.90      5/36.73      | 
|POLY-3 PERCENT (g) |     16.3%        13.9%        4.4%         3.4%        |15.3%        9.9%         0.0%         13.6%        | 
|TERMINAL (d)       |     2/23 (9%)    0/12 (0%)    0/13 (0%)    1/16 (6%)   |5/27 (19%)   2/24 (8%)    0/17 (0%)    4/30 (13%)   | 
|FIRST INCIDENCE    |     469          574          561          729 (T)     |729 (T)      511          ---          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.072N     P=0.470N     P=0.159N     P=0.161N    |P=0.542N     P=0.414N     P=0.084N     P=0.568N     | 
|POLY 3             |     P=0.047N*    P=0.560N     P=0.179N     P=0.109N    |P=0.547N     P=0.393N     P=0.055N     P=0.555N     | 
|POLY 1.5           |     P=0.045N*    P=0.558N     P=0.177N     P=0.103N    |P=0.548N     P=0.391N     P=0.050N     P=0.563N     | 
|POLY 6             |     P=0.051N     P=0.568N     P=0.186N     P=0.119N    |P=0.551N     P=0.395N     P=0.065N     P=0.552N     | 
|LOGISTIC REGRESSION|     P=0.039N*    P=0.586N     P=0.141N     P=0.098N    |P=0.554N     P=0.394N     (e)          P=0.580N     | 
|COCH-ARM / FISHERS |     P=0.043N*    P=0.564N     P=0.171N     P=0.099N    |P=0.553N     P=0.388N     P=0.042N*    P=0.579N     | 
|ORDER RESTRICTED   |     P=0.049N*    (e)          (e)          (e)         |P=0.239N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/34 (24%)   5/24 (21%)   9/26 (35%)   6/34 (18%)  |31/36 (86%)  22/34 (65%)  15/30 (50%)  25/39 (64%)  | 
|POLY-3 RATE (b)    |     8/29.63      5/22.01      9/22.50      6/29.36     |31/35.50     22/32.41     15/27.66     25/37.87     | 
|POLY-3 PERCENT (g) |     27.0%        22.7%        40.0%        20.4%       |87.3%        67.9%        54.2%        66.0%        | 
|TERMINAL (d)       |     7/23 (30%)   2/12 (17%)   7/13 (54%)   5/16 (31%)  |24/27 (89%)  14/24 (58%)  10/17 (59%)  20/30 (67%)  | 
|FIRST INCIDENCE    |     695          542          660          651         |423          511          511          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.451      P=0.606N     P=0.118      P=0.599     |P=0.098N     P=0.131N     P=0.054N     P=0.052N     | 
|POLY 3             |     P=0.442N     P=0.489N     P=0.242      P=0.387N    |P=0.057N     P=0.046N*    P=0.002N**   P=0.025N*    | 
|POLY 1.5           |     P=0.427N     P=0.504N     P=0.244      P=0.383N    |P=0.056N     P=0.041N*    P<0.001N**   P=0.025N*    | 
|POLY 6             |     P=0.470N     P=0.482N     P=0.231      P=0.403N    |P=0.068N     P=0.045N*    P=0.004N**   P=0.028N*    | 
|LOGISTIC REGRESSION|     P=0.429N     P=0.529N     P=0.180      P=0.454N    |P=0.066N     P=0.037N*    P=0.002N**   P=0.028N*    | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.535N     P=0.255      P=0.383N    |P=0.068N     P=0.035N*    P=0.002N**   P=0.026N*    | 
|ORDER RESTRICTED   |     P=0.308N     (e)          (e)          (e)         |P=0.005N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/34 (3%)    1/24 (4%)    1/26 (4%)    0/34 (0%)   |1/36 (3%)    7/34 (21%)   3/30 (10%)   6/39 (15%)   | 
|POLY-3 RATE (b)    |     1/30.23      1/21.39      1/22.68      0/29.07     |1/32.62      7/31.24      3/25.38      6/37.06      | 
|POLY-3 PERCENT (g) |     3.3%         4.7%         4.4%         0.0%        |3.1%         22.4%        11.8%        16.2%        | 
|TERMINAL (d)       |     0/23 (0%)    0/12 (0%)    0/13 (0%)    0/16 (0%)   |1/27 (4%)    5/24 (21%)   2/17 (12%)   4/30 (13%)   | 
|FIRST INCIDENCE    |     469          542          561          ---         |729 (T)      423          587          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.303N     P=0.744N     P=0.751N     P=0.500N    |P=0.317      P=0.024 *    P=0.191      P=0.078      | 
|POLY 3             |     P=0.290N     P=0.682      P=0.696      P=0.508N    |P=0.327      P=0.022 *    P=0.218      P=0.076      | 
|POLY 1.5           |     P=0.286N     P=0.682      P=0.696      P=0.504N    |P=0.319      P=0.022 *    P=0.229      P=0.073      | 
|POLY 6             |     P=0.297N     P=0.679      P=0.693      P=0.514N    |P=0.332      P=0.022 *    P=0.201      P=0.078      | 
|LOGISTIC REGRESSION|     P=0.225N     P=0.297      P=0.749N     P=0.388N    |P=0.264      P=0.028 *    P=0.232      P=0.058      | 
|COCH-ARM / FISHERS |     P=0.278N     P=0.661      P=0.683      P=0.500N    |P=0.304      P=0.022 *    P=0.241      P=0.067      | 
|ORDER RESTRICTED   |     P=0.258N     (e)          (e)          (e)         |P=0.050      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/45 (16%)   7/43 (16%)   7/47 (15%)   2/44 (5%)   |37/50 (74%)  39/50 (78%)  34/50 (68%)  38/50 (76%)  | 
|POLY-3 RATE (b)    |     7/41.07      7/39.83      7/41.36      2/38.50     |37/45.79     39/45.03     34/45.02     38/48.58     | 
|POLY-3 PERCENT (g) |     17.0%        17.6%        16.9%        5.2%        |80.8%        86.6%        75.5%        78.2%        | 
|TERMINAL (d)       |     5/34 (15%)   4/27 (15%)   4/30 (13%)   1/27 (4%)   |31/37 (84%)  34/36 (94%)  27/33 (82%)  32/41 (78%)  | 
|FIRST INCIDENCE    |     630          672          703          671         |623          626          615          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.094N     P=0.461      P=0.526      P=0.130N    |P=0.185N     P=0.313      P=0.509      P=0.360N     | 
|POLY 3             |     P=0.068N     P=0.591      P=0.609N     P=0.093N    |P=0.220N     P=0.306      P=0.351N     P=0.477N     | 
|POLY 1.5           |     P=0.063N     P=0.589      P=0.598N     P=0.088N    |P=0.318N     P=0.339      P=0.335N     P=0.563N     | 
|POLY 6             |     P=0.076N     P=0.581      P=0.601      P=0.101N    |P=0.136N     P=0.283      P=0.394N     P=0.381N     | 
|LOGISTIC REGRESSION|     P=0.069N     P=0.592      P=0.614N     P=0.092N    |P=0.176N     P=0.273      P=0.474N     P=0.449N     | 
|COCH-ARM / FISHERS |     P=0.056N     P=0.578      P=0.579N     P=0.084N    |P=0.480N     P=0.408      P=0.330N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.094N     (e)          (e)          (e)         |P=0.297N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/45 (0%)    0/43 (0%)    0/47 (0%)    0/44 (0%)   |4/50 (8%)    1/50 (2%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/40.58      0/39.50      0/41.17      0/38.28     |4/46.88      1/44.23      3/45.21      2/48.32      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |8.5%         2.3%         6.6%         4.1%         | 
|TERMINAL (d)       |     0/34 (0%)    0/27 (0%)    0/30 (0%)    0/27 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |511          563          401          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.446N     P=0.192N     P=0.504N     P=0.321N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.434N     P=0.197N     P=0.520N     P=0.324N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.446N     P=0.190N     P=0.509N     P=0.328N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.425N     P=0.205N     P=0.538N     P=0.322N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.325      P=0.098N     P=0.474N     P=0.723      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.470N     P=0.181N     P=0.500N     P=0.339N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.269N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/45 (0%)    0/43 (0%)    0/47 (0%)    0/44 (0%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/40.58      0/39.50      0/41.17      0/38.28     |2/44.75      1/44.02      1/43.24      4/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         2.3%         2.3%         8.5%         | 
|TERMINAL (d)       |     0/34 (0%)    0/27 (0%)    0/30 (0%)    0/27 (0%)   |2/37 (5%)    0/36 (0%)    1/33 (3%)    4/41 (10%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      639          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.177      P=0.509N     P=0.540N     P=0.385      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.154      P=0.506N     P=0.512N     P=0.360      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.150      P=0.504N     P=0.506N     P=0.352      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.157      P=0.506N     P=0.522N     P=0.368      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.164      P=0.503N     P=0.540N     P=0.385      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.143      P=0.500N     P=0.500N     P=0.339      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.154      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/45 (0%)    1/43 (2%)    2/47 (4%)    2/44 (5%)   |7/50 (14%)   11/50 (22%)  10/50 (20%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     0/40.58      1/39.50      2/41.82      2/38.33     |7/44.75      11/44.41     10/44.16     9/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.5%         4.8%         5.2%        |15.6%        24.8%        22.7%        19.2%        | 
|TERMINAL (d)       |     0/34 (0%)    1/27 (4%)    0/30 (0%)    1/27 (4%)   |7/37 (19%)   8/36 (22%)   8/33 (24%)   9/41 (22%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      566          718         |729 (T)      623          547          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.151      P=0.454      P=0.238      P=0.196     |P=0.485N     P=0.204      P=0.220      P=0.480      | 
|POLY 3             |     P=0.155      P=0.495      P=0.244      P=0.224     |P=0.534N     P=0.209      P=0.284      P=0.434      | 
|POLY 1.5           |     P=0.160      P=0.494      P=0.245      P=0.228     |P=0.540      P=0.210      P=0.291      P=0.419      | 
|POLY 6             |     P=0.148      P=0.492      P=0.241      P=0.218     |P=0.520N     P=0.211      P=0.272      P=0.448      | 
|LOGISTIC REGRESSION|     P=0.169      P=0.454      P=0.268      P=0.210     |P=0.521N     P=0.195      P=0.261      P=0.480      | 
|COCH-ARM / FISHERS |     P=0.166      P=0.489      P=0.258      P=0.242     |P=0.503      P=0.218      P=0.298      P=0.393      | 
|ORDER RESTRICTED   |     P=0.146      (e)          (e)          (e)         |P=0.348      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/19 (11%)   0/20 (0%)    2/19 (11%)   2/23 (9%)   |4/18 (22%)   2/10 (20%)   1/13 (8%)    0/16 (0%)    | 
|POLY-3 RATE (b)    |     2/16.43      0/18.04      2/17.18      2/19.70     |4/17.60      2/9.29       1/11.52      0/15.47      | 
|POLY-3 PERCENT (g) |     12.2%        0.0%         11.6%        10.2%       |22.7%        21.5%        8.7%         0.0%         | 
|TERMINAL (d)       |     0/13 (0%)    0/10 (0%)    0/10 (0%)    0/9 (0%)    |0/11 (0%)    0/6 (0%)     0/6 (0%)     0/14 (0%)    | 
|FIRST INCIDENCE    |     469          ---          475          465         |423          511          511          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.340      P=0.228N     P=0.676N     P=0.684N    |P=0.037N*    P=0.353N     P=0.189N     P=0.062N     | 
|POLY 3             |     P=0.378      P=0.211N     P=0.682N     P=0.631N    |P=0.028N*    P=0.655N     P=0.319N     P=0.065N     | 
|POLY 1.5           |     P=0.387      P=0.213N     P=0.685N     P=0.625N    |P=0.028N*    P=0.644N     P=0.301N     P=0.064N     | 
|POLY 6             |     P=0.366      P=0.216N     P=0.691N     P=0.648N    |P=0.028N*    P=0.671N     P=0.349N     P=0.066N     | 
|LOGISTIC REGRESSION|     P=0.349      P=0.879N     P=0.289      P=0.599     |P=0.258N     (e)          P=0.257N     (e)          | 
|COCH-ARM / FISHERS |     P=0.398      P=0.231N     P=0.698N     P=0.620N    |P=0.029N*    P=0.642N     P=0.285N     P=0.066N     | 
|ORDER RESTRICTED   |     P=0.465      (e)          (e)          (e)         |P=0.020N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/19 (63%)  10/20 (50%)  13/19 (68%)  14/23 (61%) |12/18 (67%)  5/10 (50%)   9/13 (69%)   13/16 (81%)  | 
|POLY-3 RATE (b)    |     12/15.04     10/18.70     13/16.91     14/19.51    |12/15.50     5/8.04       9/11.21      13/15.78     | 
|POLY-3 PERCENT (g) |     79.8%        53.5%        76.9%        71.8%       |77.4%        62.2%        80.3%        82.4%        | 
|TERMINAL (d)       |     12/13 (92%)  5/10 (50%)   10/10 (100%) 8/9 (89%)   |10/11 (91%)  5/6 (83%)    6/6 (100%)   12/14 (86%)  | 
|FIRST INCIDENCE    |     729 (T)      663          607          639         |644          729 (T)      699          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032 *    P=0.559      P=0.079      P=0.042 *   |P=0.544N     P=0.214N     P=0.342      P=0.374N     | 
|POLY 3             |     P=0.319      P=0.095N     P=0.604N     P=0.436N    |P=0.293      P=0.374N     P=0.631      P=0.541      | 
|POLY 1.5           |     P=0.362      P=0.164N     P=0.652      P=0.490N    |P=0.198      P=0.339N     P=0.623      P=0.427      | 
|POLY 6             |     P=0.255      P=0.052N     P=0.553N     P=0.399N    |P=0.457      P=0.463N     P=0.601      P=0.666      | 
|LOGISTIC REGRESSION|     P=0.202      P=0.090N     P=0.713      P=0.595N    |P=0.549      P=0.473N     P=0.562      P=0.653N     | 
|COCH-ARM / FISHERS |     P=0.400      P=0.307N     P=0.500      P=0.567N    |P=0.117      P=0.321N     P=0.597      P=0.285      | 
|ORDER RESTRICTED   |     P=0.312N     (e)          (e)          (e)         |P=0.324      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/49 (2%)    2/49 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.39      1/43.53      2/43.26      1/43.44     |0/44.75      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         4.6%         2.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/31 (3%)    1/28 (4%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          638          703          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.357      P=0.510      P=0.215      P=0.450     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.373      P=0.501      P=0.236      P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.379      P=0.502      P=0.237      P=0.503     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.362      P=0.496      P=0.233      P=0.494     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.380      P=0.465      P=0.233      P=0.450     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.383      P=0.500      P=0.247      P=0.505     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.224      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/49 (2%)    6/49 (12%)   1/50 (2%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.39      1/43.53      6/43.46      1/43.44     |1/44.79      2/44.07      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         13.8%        2.3%        |2.2%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    4/31 (13%)   1/28 (4%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      638          675          729 (T)     |718          623          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.361      P=0.735      P=0.043 *    P=0.705     |P=0.121N     P=0.493      P=0.533N     P=0.490N     | 
|POLY 3             |     P=0.390      P=0.760N     P=0.055      P=0.760N    |P=0.123N     P=0.494      P=0.507N     P=0.490N     | 
|POLY 1.5           |     P=0.399      P=0.758N     P=0.056      P=0.757N    |P=0.123N     P=0.496      P=0.504N     P=0.494N     | 
|POLY 6             |     P=0.374      P=0.756      P=0.054      P=0.755     |P=0.124N     P=0.494      P=0.513N     P=0.487N     | 
|LOGISTIC REGRESSION|     P=0.400      P=0.760      P=0.054      P=0.705     |P=0.124N     P=0.501      P=0.513N     P=0.489N     | 
|COCH-ARM / FISHERS |     P=0.410      P=0.753N     P=0.056      P=0.747N    |P=0.124N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.170      (e)          (e)          (e)         |P=0.156N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    3/49 (6%)    0/49 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.39      3/43.59      0/43.16      1/43.44     |0/44.75      1/43.69      0/43.24      1/47.34      | 
|POLY-3 PERCENT (g) |     2.3%         6.9%         0.0%         2.3%        |0.0%         2.3%         0.0%         2.1%         | 
|TERMINAL (d)       |     1/36 (3%)    2/27 (7%)    0/31 (0%)    1/28 (4%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      619          ---          729 (T)     |---          729 (T)      ---          635          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309N     P=0.233      P=0.530N     P=0.705     |P=0.503      P=0.495      (e)          P=0.527      | 
|POLY 3             |     P=0.277N     P=0.307      P=0.501N     P=0.760N    |P=0.490      P=0.495      (e)          P=0.511      | 
|POLY 1.5           |     P=0.275N     P=0.309      P=0.501N     P=0.757N    |P=0.485      P=0.497      (e)          P=0.507      | 
|POLY 6             |     P=0.283N     P=0.297      P=0.504N     P=0.755     |P=0.494      P=0.494      (e)          P=0.516      | 
|LOGISTIC REGRESSION|     P=0.279N     P=0.305      (e)          P=0.705     |P=0.467      P=0.495      (e)          P=0.438      | 
|COCH-ARM / FISHERS |     P=0.275N     P=0.309      P=0.500N     P=0.747N    |P=0.478      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.268N     (e)          (e)          (e)         |P=0.262      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |5/50 (10%)   1/50 (2%)    1/49 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |5/46.71      1/44.00      1/42.24      4/47.00      | 
|POLY-3 PERCENT (g) |                                                        |10.7%        2.3%         2.4%         8.5%         | 
|TERMINAL (d)       |                                                        |2/37 (5%)    0/36 (0%)    1/32 (3%)    4/41 (10%)   | 
|FIRST INCIDENCE    |                                                        |462          644          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.537      P=0.118N     P=0.126N     P=0.454N     | 
|POLY 3             |                                                        |P=0.513      P=0.116N     P=0.126N     P=0.496N     | 
|POLY 1.5           |                                                        |P=0.507      P=0.111N     P=0.117N     P=0.497N     | 
|POLY 6             |                                                        |P=0.516      P=0.120N     P=0.139N     P=0.496N     | 
|LOGISTIC REGRESSION|                                                        |P=0.425      P=0.065N     P=0.086N     P=0.630N     | 
|COCH-ARM / FISHERS |                                                        |P=0.493      P=0.102N     P=0.107N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.154N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Periovarian Tissue                                                                                                        | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/50 (8%)    4/50 (8%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |4/44.79      4/43.69      2/42.24      1/47.00      | 
|POLY-3 PERCENT (g) |                                                        |8.9%         9.2%         4.7%         2.1%         | 
|TERMINAL (d)       |                                                        |3/37 (8%)    4/36 (11%)   2/32 (6%)    1/41 (2%)    | 
|FIRST INCIDENCE    |                                                        |718          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.071N     P=0.626      P=0.408N     P=0.155N     | 
|POLY 3             |                                                        |P=0.074N     P=0.630      P=0.364N     P=0.164N     | 
|POLY 1.5           |                                                        |P=0.078N     P=0.634      P=0.356N     P=0.170N     | 
|POLY 6             |                                                        |P=0.072N     P=0.626      P=0.379N     P=0.160N     | 
|LOGISTIC REGRESSION|                                                        |P=0.075N     P=0.621      P=0.407N     P=0.158N     | 
|COCH-ARM / FISHERS |                                                        |P=0.084N     P=0.643N     P=0.349N     P=0.181N     | 
|ORDER RESTRICTED   |                                                        |P=0.126N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/49 (47%)  23/49 (47%)  27/49 (55%)  15/50 (30%) |15/50 (30%)  8/49 (16%)   9/49 (18%)   16/49 (33%)  | 
|POLY-3 RATE (b)    |     23/46.12     23/45.20     27/46.42     15/44.63    |15/45.64     8/43.61      9/43.02      16/46.90     | 
|POLY-3 PERCENT (g) |     49.9%        50.9%        58.2%        33.6%       |32.9%        18.3%        20.9%        34.1%        | 
|TERMINAL (d)       |     16/36 (44%)  14/27 (52%)  15/31 (48%)  10/28 (36%) |12/37 (32%)  7/36 (19%)   6/32 (19%)   14/41 (34%)  | 
|FIRST INCIDENCE    |     469          574          209          562         |423          541          636          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179N     P=0.260      P=0.175      P=0.249N    |P=0.304      P=0.093N     P=0.221N     P=0.544N     | 
|POLY 3             |     P=0.074N     P=0.545      P=0.275      P=0.084N    |P=0.233      P=0.090N     P=0.151N     P=0.537      | 
|POLY 1.5           |     P=0.064N     P=0.571      P=0.282      P=0.071N    |P=0.217      P=0.089N     P=0.142N     P=0.510      | 
|POLY 6             |     P=0.094N     P=0.486      P=0.255      P=0.110N    |P=0.252      P=0.090N     P=0.163N     P=0.569      | 
|LOGISTIC REGRESSION|     P=0.058N     P=0.573N     P=0.272      P=0.065N    |P=0.239      P=0.090N     P=0.149N     P=0.529      | 
|COCH-ARM / FISHERS |     P=0.056N     P=0.580N     P=0.272      P=0.063N    |P=0.193      P=0.084N     P=0.132N     P=0.473      | 
|ORDER RESTRICTED   |     P=0.041N*    (e)          (e)          (e)         |P=0.211      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Duct                                                                                                                   | 
|     Cyst Focal                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     15/49 (31%)  13/49 (27%)  19/49 (39%)  16/50 (32%) |11/50 (22%)  16/49 (33%)  15/49 (31%)  19/49 (39%)  | 
|POLY-3 RATE (b)    |     15/43.62     13/43.93     19/44.42     16/44.40    |11/45.18     16/45.09     15/43.41     19/46.45     | 
|POLY-3 PERCENT (g) |     34.4%        29.6%        42.8%        36.0%       |24.4%        35.5%        34.6%        40.9%        | 
|TERMINAL (d)       |     13/36 (36%)  9/27 (33%)   14/31 (45%)  11/28 (39%) |8/37 (22%)   10/36 (28%)  13/32 (41%)  18/41 (44%)  | 
|FIRST INCIDENCE    |     695          582          647          651         |623          433          401          703          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.172      P=0.457      P=0.141      P=0.242     |P=0.177      P=0.180      P=0.143      P=0.116      | 
|POLY 3             |     P=0.304      P=0.400N     P=0.276      P=0.525     |P=0.103      P=0.176      P=0.204      P=0.069      | 
|POLY 1.5           |     P=0.308      P=0.396N     P=0.271      P=0.530     |P=0.098      P=0.170      P=0.218      P=0.063      | 
|POLY 6             |     P=0.298      P=0.429N     P=0.271      P=0.505     |P=0.105      P=0.186      P=0.180      P=0.074      | 
|LOGISTIC REGRESSION|     P=0.269      P=0.476N     P=0.231      P=0.451     |P=0.115      P=0.160      P=0.195      P=0.087      | 
|COCH-ARM / FISHERS |     P=0.316      P=0.412N     P=0.262      P=0.527     |P=0.087      P=0.168      P=0.228      P=0.055      | 
|ORDER RESTRICTED   |     P=0.367      (e)          (e)          (e)         |P=0.065      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    4/50 (8%)    1/49 (2%)    3/50 (6%)   |10/49 (20%)  6/49 (12%)   2/50 (4%)    13/50 (26%)  | 
|POLY-3 RATE (b)    |     2/42.47      4/43.94      1/43.56      3/43.56     |10/45.11     6/43.23      2/43.24      13/47.73     | 
|POLY-3 PERCENT (g) |     4.7%         9.1%         2.3%         6.9%        |22.2%        13.9%        4.6%         27.2%        | 
|TERMINAL (d)       |     2/36 (6%)    3/27 (11%)   0/31 (0%)    2/28 (7%)   |8/36 (22%)   6/36 (17%)   2/33 (6%)    11/41 (27%)  | 
|FIRST INCIDENCE    |     729 (T)      693          703          699         |423          729 (T)      729 (T)      542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.577      P=0.227      P=0.541N     P=0.402     |P=0.241      P=0.210N     P=0.023N*    P=0.435      | 
|POLY 3             |     P=0.523N     P=0.353      P=0.491N     P=0.512     |P=0.191      P=0.231N     P=0.016N*    P=0.373      | 
|POLY 1.5           |     P=0.520N     P=0.358      P=0.491N     P=0.517     |P=0.184      P=0.223N     P=0.014N*    P=0.359      | 
|POLY 6             |     P=0.530N     P=0.336      P=0.496N     P=0.499     |P=0.197      P=0.238N     P=0.019N*    P=0.388      | 
|LOGISTIC REGRESSION|     P=0.540N     P=0.301      P=0.503N     P=0.472     |P=0.199      P=0.209N     P=0.014N*    P=0.317      | 
|COCH-ARM / FISHERS |     P=0.519N     P=0.359      P=0.492N     P=0.520     |P=0.177      P=0.207N     P=0.013N*    P=0.337      | 
|ORDER RESTRICTED   |     P=0.504N     (e)          (e)          (e)         |P=0.052      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |1/49 (2%)    2/49 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.47      0/43.80      0/43.46      0/43.44     |1/43.75      2/44.04      2/43.64      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         4.5%         4.6%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |1/36 (3%)    1/36 (3%)    1/33 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      423          615          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.238N     P=0.498      P=0.480      P=0.474N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.236N     P=0.502      P=0.499      P=0.486N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.242N     P=0.501      P=0.503      P=0.490N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.231N     P=0.504      P=0.492      P=0.482N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.296N     P=0.531      P=0.507      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.251N     P=0.500      P=0.508      P=0.495N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.212N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/50 (2%)    1/49 (2%)    1/50 (2%)   |2/49 (4%)    2/49 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/42.47      1/43.80      1/43.46      1/43.44     |2/43.75      2/43.89      1/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     4.7%         2.3%         2.3%         2.3%        |4.6%         4.6%         2.3%         4.3%         | 
|TERMINAL (d)       |     2/36 (6%)    1/27 (4%)    1/31 (3%)    1/28 (4%)   |2/36 (6%)    1/36 (3%)    1/33 (3%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      511          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.482N     P=0.600N     P=0.552N     P=0.588N    |P=0.509N     P=0.691      P=0.530N     P=0.647N     | 
|POLY 3             |     P=0.432N     P=0.489N     P=0.492N     P=0.492N    |P=0.533N     P=0.693N     P=0.504N     P=0.668N     | 
|POLY 1.5           |     P=0.432N     P=0.485N     P=0.492N     P=0.488N    |P=0.537N     P=0.694      P=0.499N     P=0.675N     | 
|POLY 6             |     P=0.432N     P=0.502N     P=0.498N     P=0.503N    |P=0.531N     P=0.691N     P=0.513N     P=0.661N     | 
|LOGISTIC REGRESSION|     P=0.482N     P=0.600N     P=0.552N     P=0.588N    |P=0.541N     P=0.689N     P=0.530N     P=0.647N     | 
|COCH-ARM / FISHERS |     P=0.430N     P=0.485N     P=0.492N     P=0.485N    |P=0.544N     P=0.691N     P=0.492N     P=0.684N     | 
|ORDER RESTRICTED   |     P=0.403N     (e)          (e)          (e)         |P=0.593N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cytoplasmic Alteration Focal                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/48 (6%)    7/50 (14%)   3/49 (6%)    8/50 (16%)  |3/49 (6%)    1/49 (2%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     3/42.47      7/45.14      3/43.46      8/43.63     |3/44.55      1/43.61      2/43.36      3/47.23      | 
|POLY-3 PERCENT (g) |     7.1%         15.5%        6.9%         18.3%       |6.7%         2.3%         4.6%         6.4%         | 
|TERMINAL (d)       |     3/36 (8%)    2/27 (7%)    3/31 (10%)   7/28 (25%)  |2/36 (6%)    0/36 (0%)    1/33 (3%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     729 (T)      542          729 (T)      678         |423          623          699          670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.146      P=0.108      P=0.593      P=0.043 *   |P=0.448      P=0.308N     P=0.532N     P=0.613N     | 
|POLY 3             |     P=0.197      P=0.182      P=0.652N     P=0.105     |P=0.434      P=0.313N     P=0.512N     P=0.635N     | 
|POLY 1.5           |     P=0.203      P=0.183      P=0.651N     P=0.110     |P=0.427      P=0.311N     P=0.503N     P=0.642N     | 
|POLY 6             |     P=0.185      P=0.173      P=0.660N     P=0.096     |P=0.441      P=0.312N     P=0.525N     P=0.627N     | 
|LOGISTIC REGRESSION|     P=0.201      P=0.174      P=0.593      P=0.072     |P=0.372      P=0.270N     P=0.478N     P=0.605      | 
|COCH-ARM / FISHERS |     P=0.209      P=0.176      P=0.651N     P=0.113     |P=0.411      P=0.309N     P=0.490N     P=0.651N     | 
|ORDER RESTRICTED   |     P=0.081      (e)          (e)          (e)         |P=0.487N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    2/50 (4%)    0/49 (0%)    0/50 (0%)   |11/49 (22%)  14/49 (29%)  11/50 (22%)  3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/42.81      2/43.80      0/43.46      0/43.44     |11/45.28     14/45.01     11/44.74     3/47.59      | 
|POLY-3 PERCENT (g) |     4.7%         4.6%         0.0%         0.0%        |24.3%        31.1%        24.6%        6.3%         | 
|TERMINAL (d)       |     1/36 (3%)    2/27 (7%)    0/31 (0%)    0/28 (0%)   |8/36 (22%)   10/36 (28%)  6/33 (18%)   2/41 (5%)    | 
|FIRST INCIDENCE    |     636          729 (T)      ---          ---         |462          423          514          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.076N     P=0.615      P=0.256N     P=0.262N    |P=0.005N**   P=0.322      P=0.517      P=0.015N*    | 
|POLY 3             |     P=0.066N     P=0.686N     P=0.234N     P=0.234N    |P=0.003N**   P=0.313      P=0.584      P=0.015N*    | 
|POLY 1.5           |     P=0.066N     P=0.680N     P=0.233N     P=0.230N    |P=0.004N**   P=0.315      P=0.594N     P=0.016N*    | 
|POLY 6             |     P=0.066N     P=0.687      P=0.238N     P=0.242N    |P=0.003N**   P=0.312      P=0.564      P=0.014N*    | 
|LOGISTIC REGRESSION|     P=0.066N     P=0.684N     P=0.233N     P=0.228N    |P=0.006N**   P=0.327      P=0.568N     P=0.028N*    | 
|COCH-ARM / FISHERS |     P=0.066N     P=0.676N     P=0.242N     P=0.237N    |P=0.005N**   P=0.322      P=0.574N     P=0.018N*    | 
|ORDER RESTRICTED   |     P=0.113N     (e)          (e)          (e)         |P=0.006N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hemorrhage Focal                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    2/50 (4%)    1/49 (2%)    3/50 (6%)   |9/49 (18%)   6/49 (12%)   10/50 (20%)  2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/43.05      2/43.80      1/43.46      3/44.03     |9/44.88      6/43.23      10/43.24     2/47.00      | 
|POLY-3 PERCENT (g) |     4.7%         4.6%         2.3%         6.8%        |20.1%        13.9%        23.1%        4.3%         | 
|TERMINAL (d)       |     1/36 (3%)    2/27 (7%)    1/31 (3%)    1/28 (4%)   |5/36 (14%)   6/36 (17%)   10/33 (30%)  2/41 (5%)    | 
|FIRST INCIDENCE    |     545          729 (T)      729 (T)      590         |595          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377      P=0.623      P=0.527N     P=0.456     |P=0.045N*    P=0.299N     P=0.417      P=0.020N*    | 
|POLY 3             |     P=0.418      P=0.688N     P=0.497N     P=0.510     |P=0.044N*    P=0.314N     P=0.464      P=0.020N*    | 
|POLY 1.5           |     P=0.420      P=0.681N     P=0.494N     P=0.516     |P=0.048N*    P=0.304N     P=0.491      P=0.021N*    | 
|POLY 6             |     P=0.415      P=0.685      P=0.505N     P=0.498     |P=0.041N*    P=0.327N     P=0.420      P=0.020N*    | 
|LOGISTIC REGRESSION|     P=0.422      P=0.685N     P=0.493N     P=0.513     |P=0.047N*    P=0.294N     P=0.481      P=0.026N*    | 
|COCH-ARM / FISHERS |     P=0.421      P=0.676N     P=0.492N     P=0.520     |P=0.060N     P=0.288N     P=0.520      P=0.023N*    | 
|ORDER RESTRICTED   |     P=0.403      (e)          (e)          (e)         |P=0.020N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/48 (8%)    2/50 (4%)    3/49 (6%)    1/50 (2%)   |7/49 (14%)   5/49 (10%)   10/50 (20%)  4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/43.17      2/43.94      3/43.46      1/43.44     |7/43.75      5/44.04      10/43.24     4/47.00      | 
|POLY-3 PERCENT (g) |     9.3%         4.6%         6.9%         2.3%        |16.0%        11.4%        23.1%        8.5%         | 
|TERMINAL (d)       |     2/36 (6%)    1/27 (4%)    3/31 (10%)   1/28 (4%)   |7/36 (19%)   4/36 (11%)   10/33 (30%)  4/41 (10%)   | 
|FIRST INCIDENCE    |     545          693          729 (T)      729 (T)     |729 (T)      423          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.239N     P=0.419N     P=0.561N     P=0.233N    |P=0.291N     P=0.380N     P=0.224      P=0.189N     | 
|POLY 3             |     P=0.201N     P=0.329N     P=0.496N     P=0.176N    |P=0.314N     P=0.374N     P=0.285      P=0.221N     | 
|POLY 1.5           |     P=0.199N     P=0.321N     P=0.492N     P=0.171N    |P=0.330N     P=0.377N     P=0.299      P=0.232N     | 
|POLY 6             |     P=0.205N     P=0.348N     P=0.511N     P=0.188N    |P=0.299N     P=0.370N     P=0.263      P=0.211N     | 
|LOGISTIC REGRESSION|     P=0.197N     P=0.320N     P=0.488N     P=0.167N    |P=0.313N     P=0.384N     P=0.224      P=0.189N     | 
|COCH-ARM / FISHERS |     P=0.195N     P=0.319N     P=0.488N     P=0.168N    |P=0.359N     P=0.380N     P=0.314      P=0.251N     | 
|ORDER RESTRICTED   |     P=0.128N     (e)          (e)          (e)         |P=0.202N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Rathke's Cleft                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)   |1/49 (2%)    2/49 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.47      0/43.80      0/43.46      1/44.02     |1/43.75      2/44.39      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |2.3%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |1/36 (3%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          545         |729 (T)      433          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.185      (e)          (e)          P=0.509     |P=0.118N     P=0.500      P=0.517N     P=0.474N     | 
|POLY 3             |     P=0.188      (e)          (e)          P=0.507     |P=0.120N     P=0.505      P=0.502N     P=0.486N     | 
|POLY 1.5           |     P=0.188      (e)          (e)          P=0.509     |P=0.120N     P=0.502      P=0.499N     P=0.490N     | 
|POLY 6             |     P=0.187      (e)          (e)          P=0.503     |P=0.120N     P=0.509      P=0.508N     P=0.482N     | 
|LOGISTIC REGRESSION|     P=0.181      (e)          (e)          P=0.454     |P=0.155N     P=0.553      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.187      (e)          (e)          P=0.510     |P=0.121N     P=0.500      P=0.495N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.127      (e)          (e)          (e)         |P=0.157N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Rathke's Cleft                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    2/49 (4%)    2/50 (4%)   |1/49 (2%)    2/49 (4%)    2/50 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     1/42.47      0/43.80      2/43.88      2/43.66     |1/43.75      2/43.23      2/43.68      6/47.48      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         4.6%         4.6%        |2.3%         4.6%         4.6%         12.6%        | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    1/31 (3%)    0/28 (0%)   |1/36 (3%)    2/36 (6%)    0/33 (0%)    4/41 (10%)   | 
|FIRST INCIDENCE    |     729 (T)      ---          605          699         |729 (T)      729 (T)      636          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.170      P=0.557N     P=0.471      P=0.449     |P=0.038 *    P=0.500      P=0.469      P=0.083      | 
|POLY 3             |     P=0.188      P=0.494N     P=0.511      P=0.510     |P=0.029 *    P=0.496      P=0.500      P=0.070      | 
|POLY 1.5           |     P=0.189      P=0.491N     P=0.510      P=0.513     |P=0.027 *    P=0.497      P=0.503      P=0.066      | 
|POLY 6             |     P=0.187      P=0.501N     P=0.508      P=0.501     |P=0.031 *    P=0.496      P=0.493      P=0.075      | 
|LOGISTIC REGRESSION|     P=0.190      (e)          P=0.507      P=0.505     |P=0.028 *    P=0.500      P=0.508      P=0.066      | 
|COCH-ARM / FISHERS |     P=0.190      P=0.490N     P=0.508      P=0.515     |P=0.025 *    P=0.500      P=0.508      P=0.059      | 
|ORDER RESTRICTED   |     P=0.274      (e)          (e)          (e)         |P=0.025 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/49 (4%)    1/50 (2%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/42.39      2/43.34      1/43.73      2/43.44     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         2.3%         4.6%        |                                                    | 
|TERMINAL (d)       |     0/35 (0%)    1/27 (4%)    1/31 (3%)    2/28 (7%)   |                                                    | 
|FIRST INCIDENCE    |     ---          695          729 (T)      729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.285      P=0.198      P=0.476      P=0.190     |                                                    | 
|POLY 3             |     P=0.323      P=0.242      P=0.506      P=0.242     |                                                    | 
|POLY 1.5           |     P=0.327      P=0.244      P=0.507      P=0.245     |                                                    | 
|POLY 6             |     P=0.313      P=0.236      P=0.502      P=0.236     |                                                    | 
|LOGISTIC REGRESSION|     P=0.308      P=0.238      P=0.476      P=0.190     |                                                    | 
|COCH-ARM / FISHERS |     P=0.328      P=0.253      P=0.510      P=0.258     |                                                    | 
|ORDER RESTRICTED   |     P=0.159      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/48 (46%)  12/49 (24%)  18/50 (36%)  20/50 (40%) |                                                    | 
|POLY-3 RATE (b)    |     22/45.87     12/43.37     18/45.64     20/44.78    |                                                    | 
|POLY-3 PERCENT (g) |     48.0%        27.7%        39.4%        44.7%       |                                                    | 
|TERMINAL (d)       |     13/35 (37%)  9/27 (33%)   11/31 (36%)  16/28 (57%) |                                                    | 
|FIRST INCIDENCE    |     381          699          561          545         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.207      P=0.134N     P=0.405N     P=0.461     |                                                    | 
|POLY 3             |     P=0.323      P=0.036N*    P=0.270N     P=0.458N    |                                                    | 
|POLY 1.5           |     P=0.336      P=0.028N*    P=0.250N     P=0.408N    |                                                    | 
|POLY 6             |     P=0.304      P=0.057N     P=0.301N     P=0.539N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.349      P=0.023N*    P=0.215N     P=0.353N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.360      P=0.023N*    P=0.216N     P=0.352N    |                                                    | 
|ORDER RESTRICTED   |     P=0.232N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/50 (42%)  23/49 (47%)  29/50 (58%)  30/50 (60%) |                                                    | 
|POLY-3 RATE (b)    |     21/45.45     23/45.03     29/46.94     30/47.23    |                                                    | 
|POLY-3 PERCENT (g) |     46.2%        51.1%        61.8%        63.5%       |                                                    | 
|TERMINAL (d)       |     17/36 (47%)  14/27 (52%)  17/31 (55%)  20/28 (71%) |                                                    | 
|FIRST INCIDENCE    |     469          562          566          465         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.015 *    P=0.137      P=0.046 *    P=0.010 *   |                                                    | 
|POLY 3             |     P=0.039 *    P=0.399      P=0.094      P=0.066     |                                                    | 
|POLY 1.5           |     P=0.035 *    P=0.404      P=0.084      P=0.063     |                                                    | 
|POLY 6             |     P=0.041 *    P=0.367      P=0.105      P=0.062     |                                                    | 
|LOGISTIC REGRESSION|     P=0.029 *    P=0.406      P=0.080      P=0.055     |                                                    | 
|COCH-ARM / FISHERS |     P=0.031 *    P=0.385      P=0.081      P=0.055     |                                                    | 
|ORDER RESTRICTED   |     P=0.062      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    2/49 (4%)    3/50 (6%)    4/50 (8%)   |                                                    | 
|POLY-3 RATE (b)    |     3/43.93      2/43.53      3/43.73      4/43.75     |                                                    | 
|POLY-3 PERCENT (g) |     6.8%         4.6%         6.9%         9.1%        |                                                    | 
|TERMINAL (d)       |     1/36 (3%)    1/27 (4%)    3/31 (10%)   3/28 (11%)  |                                                    | 
|FIRST INCIDENCE    |     699          638          729 (T)      644         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.264      P=0.574N     P=0.595      P=0.408     |                                                    | 
|POLY 3             |     P=0.305      P=0.504N     P=0.661      P=0.498     |                                                    | 
|POLY 1.5           |     P=0.308      P=0.503N     P=0.662      P=0.501     |                                                    | 
|POLY 6             |     P=0.299      P=0.516N     P=0.652      P=0.485     |                                                    | 
|LOGISTIC REGRESSION|     P=0.302      P=0.506N     P=0.651      P=0.494     |                                                    | 
|COCH-ARM / FISHERS |     P=0.310      P=0.510N     P=0.661N     P=0.500     |                                                    | 
|ORDER RESTRICTED   |     P=0.417      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate: Epithelium                                                                                                             | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  4/49 (8%)    2/50 (4%)    11/50 (22%) |                                                    | 
|POLY-3 RATE (b)    |     11/44.07     4/43.20      2/43.85      11/43.76    |                                                    | 
|POLY-3 PERCENT (g) |     25.0%        9.3%         4.6%         25.1%       |                                                    | 
|TERMINAL (d)       |     10/36 (28%)  4/27 (15%)   1/31 (3%)    10/28 (36%) |                                                    | 
|FIRST INCIDENCE    |     630          729 (T)      698          639         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.207      P=0.123N     P=0.017N*    P=0.358     |                                                    | 
|POLY 3             |     P=0.291      P=0.046N*    P=0.007N**   P=0.590     |                                                    | 
|POLY 1.5           |     P=0.293      P=0.045N*    P=0.007N**   P=0.595N    |                                                    | 
|POLY 6             |     P=0.291      P=0.052N     P=0.007N**   P=0.565     |                                                    | 
|LOGISTIC REGRESSION|     P=0.265      P=0.061N     P=0.009N**   P=0.544     |                                                    | 
|COCH-ARM / FISHERS |     P=0.303      P=0.049N*    P=0.007N**   P=0.595N    |                                                    | 
|ORDER RESTRICTED   |     P=0.082      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy Focal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.39      0/43.80      0/43.73      0/43.44     |2/44.75      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |2/37 (5%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.167N     P=0.244N     P=0.264N     P=0.216N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.169N     P=0.242N     P=0.245N     P=0.226N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.170N     P=0.241N     P=0.241N     P=0.230N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.169N     P=0.244N     P=0.251N     P=0.223N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.167N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.173N     P=0.247N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.026N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     3/43.72      1/43.80      3/43.73      1/43.54     |0/44.75      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     6.9%         2.3%         6.9%         2.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     3/36 (8%)    1/27 (4%)    3/31 (10%)   0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      703         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.443N     P=0.412N     P=0.593      P=0.389N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.392N     P=0.304N     P=0.663N     P=0.306N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.392N     P=0.302N     P=0.662N     P=0.304N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.392N     P=0.315N     P=0.656      P=0.314N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.420N     P=0.412N     P=0.593      P=0.330N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.389N     P=0.309N     P=0.661N     P=0.309N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.245N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      2/44.23      0/43.73      0/43.44     |0/44.75      0/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         4.5%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    1/27 (4%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          605          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.246N     P=0.213      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.233N     P=0.240      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.232N     P=0.240      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.239N     P=0.234      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.235N     P=0.223      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.236N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.251N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic Focal                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      2/43.80      0/43.73      0/43.44     |0/44.75      1/43.69      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         0.0%         0.0%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    2/27 (7%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.256N     P=0.177      (e)          (e)         |P=0.410N     P=0.495      (e)          (e)          | 
|POLY 3             |     P=0.234N     P=0.237      (e)          (e)         |P=0.431N     P=0.495      (e)          (e)          | 
|POLY 1.5           |     P=0.233N     P=0.239      (e)          (e)         |P=0.428N     P=0.497      (e)          (e)          | 
|POLY 6             |     P=0.241N     P=0.230      (e)          (e)         |P=0.434N     P=0.494      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.177      (e)          (e)         |(e)          P=0.495      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.236N     P=0.247      (e)          (e)         |P=0.423N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.249N     (e)          (e)          (e)         |P=0.367N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Angiectasis Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/49 (4%)    1/49 (2%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.62      2/43.23      1/43.26      3/43.80     |0/44.75      1/43.69      0/43.24      1/47.34      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         2.3%         6.9%        |0.0%         2.3%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    1/27 (4%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          721          703          678         |---          729 (T)      ---          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.129      P=0.186      P=0.489      P=0.106     |P=0.501      P=0.495      (e)          P=0.522      | 
|POLY 3             |     P=0.148      P=0.240      P=0.503      P=0.123     |P=0.490      P=0.495      (e)          P=0.511      | 
|POLY 1.5           |     P=0.150      P=0.242      P=0.503      P=0.125     |P=0.485      P=0.497      (e)          P=0.507      | 
|POLY 6             |     P=0.144      P=0.233      P=0.501      P=0.119     |P=0.494      P=0.494      (e)          P=0.516      | 
|LOGISTIC REGRESSION|     P=0.146      P=0.212      P=0.503      P=0.126     |P=0.467      P=0.495      (e)          P=0.439      | 
|COCH-ARM / FISHERS |     P=0.151      P=0.253      P=0.505      P=0.129     |P=0.478      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.060      (e)          (e)          (e)         |P=0.262      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/49 (4%)    2/49 (4%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.62      2/43.23      2/43.32      4/43.80     |0/44.75      1/43.69      0/43.24      1/47.34      | 
|POLY-3 PERCENT (g) |     0.0%         4.6%         4.6%         9.1%        |0.0%         2.3%         0.0%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    1/27 (4%)    0/31 (0%)    1/28 (4%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          721          703          678         |---          729 (T)      ---          636          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.049 *    P=0.186      P=0.224      P=0.050     |P=0.501      P=0.495      (e)          P=0.522      | 
|POLY 3             |     P=0.060      P=0.240      P=0.241      P=0.063     |P=0.490      P=0.495      (e)          P=0.511      | 
|POLY 1.5           |     P=0.061      P=0.242      P=0.241      P=0.065     |P=0.485      P=0.497      (e)          P=0.507      | 
|POLY 6             |     P=0.058      P=0.233      P=0.238      P=0.060     |P=0.494      P=0.494      (e)          P=0.516      | 
|LOGISTIC REGRESSION|     P=0.058      P=0.212      P=0.240      P=0.065     |P=0.467      P=0.495      (e)          P=0.439      | 
|COCH-ARM / FISHERS |     P=0.063      P=0.253      P=0.253      P=0.064     |P=0.478      P=0.500      (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.029 *    (e)          (e)          (e)         |P=0.262      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    6/49 (12%)   4/49 (8%)    11/50 (22%) |16/50 (32%)  21/50 (42%)  8/50 (16%)   17/50 (34%)  | 
|POLY-3 RATE (b)    |     2/43.27      6/45.56      4/44.90      11/45.11    |16/47.24     21/47.38     8/45.69      17/48.26     | 
|POLY-3 PERCENT (g) |     4.6%         13.2%        8.9%         24.4%       |33.9%        44.3%        17.5%        35.2%        | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    0/31 (0%)    3/28 (11%)  |12/37 (32%)  12/36 (33%)  3/33 (9%)    13/41 (32%)  | 
|FIRST INCIDENCE    |     511          542          209          590         |462          365          401          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.013 *    P=0.137      P=0.337      P=0.008 **  |P=0.197N     P=0.203      P=0.092N     P=0.540N     | 
|POLY 3             |     P=0.011 *    P=0.150      P=0.354      P=0.008 **  |P=0.249N     P=0.202      P=0.056N     P=0.530      | 
|POLY 1.5           |     P=0.012 *    P=0.148      P=0.353      P=0.009 **  |P=0.252N     P=0.201      P=0.052N     P=0.518      | 
|POLY 6             |     P=0.011 *    P=0.147      P=0.352      P=0.008 **  |P=0.248N     P=0.210      P=0.064N     P=0.545      | 
|LOGISTIC REGRESSION|     P=0.014 *    P=0.061      P=0.364      P=0.011 *   |P=0.342N     P=0.225      P=0.036N*    P=0.442      | 
|COCH-ARM / FISHERS |     P=0.013 *    P=0.141      P=0.349      P=0.009 **  |P=0.264N     P=0.204      P=0.050N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.003 **   (e)          (e)          (e)         |P=0.142N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    1/49 (2%)    0/49 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/43.13      1/43.45      0/43.16      0/43.44     |1/45.21      1/44.23      1/43.24      2/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         0.0%         0.0%        |2.2%         2.3%         2.3%         4.3%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    1/33 (3%)    2/41 (5%)    | 
|FIRST INCIDENCE    |     574          663          ---          ---         |594          563          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.203N     P=0.756N     P=0.491N     P=0.496N    |P=0.374      P=0.755      P=0.743      P=0.531      | 
|POLY 3             |     P=0.201N     P=0.759N     P=0.500N     P=0.499N    |P=0.359      P=0.756      P=0.751      P=0.514      | 
|POLY 1.5           |     P=0.201N     P=0.756N     P=0.498N     P=0.495N    |P=0.354      P=0.757      P=0.755      P=0.509      | 
|POLY 6             |     P=0.202N     P=0.755      P=0.504N     P=0.506N    |P=0.363      P=0.754      P=0.743      P=0.517      | 
|LOGISTIC REGRESSION|     P=0.184N     P=0.721      P=0.462N     P=0.514N    |P=0.306      P=0.720N     P=0.756N     P=0.472      | 
|COCH-ARM / FISHERS |     P=0.199N     P=0.747N     P=0.495N     P=0.490N    |P=0.342      P=0.753N     P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.250N     (e)          (e)          (e)         |P=0.435      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Focal Histiocytic                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    1/49 (2%)    2/49 (4%)    1/50 (2%)   |2/50 (4%)    4/50 (8%)    2/50 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     1/42.62      1/43.20      2/43.16      1/43.44     |2/44.75      4/43.69      2/43.24      5/47.00      | 
|POLY-3 PERCENT (g) |     2.4%         2.3%         4.6%         2.3%        |4.5%         9.2%         4.6%         10.6%        | 
|TERMINAL (d)       |     1/36 (3%)    1/27 (4%)    2/31 (7%)    1/28 (4%)   |2/37 (5%)    4/36 (11%)   2/33 (6%)    5/41 (12%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.518      P=0.697      P=0.448      P=0.705     |P=0.308      P=0.323      P=0.654      P=0.259      | 
|POLY 3             |     P=0.564      P=0.758N     P=0.504      P=0.757N    |P=0.276      P=0.326      P=0.682      P=0.237      | 
|POLY 1.5           |     P=0.569      P=0.755N     P=0.505      P=0.753N    |P=0.269      P=0.330      P=0.687      P=0.229      | 
|POLY 6             |     P=0.557      P=0.757      P=0.499      P=0.759     |P=0.283      P=0.322      P=0.672      P=0.243      | 
|LOGISTIC REGRESSION|     P=0.518      P=0.697      P=0.448      P=0.705     |P=0.308      P=0.323      P=0.654      P=0.259      | 
|COCH-ARM / FISHERS |     P=0.574      P=0.747N     P=0.508      P=0.742N    |P=0.255      P=0.339      P=0.691N     P=0.218      | 
|ORDER RESTRICTED   |     P=0.590      (e)          (e)          (e)         |P=0.196      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.72      1/44.02      0/43.73      4/44.26     |0/44.75      1/44.07      1/43.58      1/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         0.0%         9.0%        |0.0%         2.3%         2.3%         2.1%         | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     729 (T)      672          ---          644         |---          623          636          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.064      P=0.720      P=0.530N     P=0.162     |P=0.447      P=0.505      P=0.490      P=0.520      | 
|POLY 3             |     P=0.063      P=0.759N     P=0.500N     P=0.182     |P=0.440      P=0.497      P=0.495      P=0.510      | 
|POLY 1.5           |     P=0.063      P=0.758N     P=0.500N     P=0.182     |P=0.433      P=0.498      P=0.497      P=0.506      | 
|POLY 6             |     P=0.063      P=0.757      P=0.503N     P=0.179     |P=0.447      P=0.497      P=0.490      P=0.513      | 
|LOGISTIC REGRESSION|     P=0.065      P=0.762N     (e)          P=0.179     |P=0.383      P=0.524      P=0.509      P=0.520      | 
|COCH-ARM / FISHERS |     P=0.065      P=0.753N     P=0.500N     P=0.181     |P=0.419      P=0.500      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.035 *    (e)          (e)          (e)         |P=0.320      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.72      4/44.16      0/43.73      1/43.54     |0/44.75      2/44.75      1/44.08      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         9.1%         0.0%         2.3%        |0.0%         4.5%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          695          ---          703         |---          433          401          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.334N     P=0.051      (e)          P=0.472     |P=0.325N     P=0.232      P=0.500      (e)          | 
|POLY 3             |     P=0.301N     P=0.061      (e)          P=0.499     |P=0.322N     P=0.237      P=0.497      (e)          | 
|POLY 1.5           |     P=0.299N     P=0.062      (e)          P=0.501     |P=0.326N     P=0.237      P=0.499      (e)          | 
|POLY 6             |     P=0.309N     P=0.058      (e)          P=0.495     |P=0.319N     P=0.238      P=0.492      (e)          | 
|LOGISTIC REGRESSION|     P=0.306N     P=0.062      (e)          P=0.499     |P=0.580N     P=0.298      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.304N     P=0.059      (e)          P=0.500     |P=0.333N     P=0.247      P=0.500      (e)          | 
|ORDER RESTRICTED   |     P=0.220      (e)          (e)          (e)         |P=0.314N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   2/50 (4%)    4/50 (8%)   |2/50 (4%)    7/50 (14%)   0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.81      5/44.72      2/44.40      4/44.24     |2/44.80      7/46.26      0/43.24      1/47.23      | 
|POLY-3 PERCENT (g) |     2.3%         11.2%        4.5%         9.0%        |4.5%         15.1%        0.0%         2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    2/36 (6%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     706          619          561          644         |717          433          ---          670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.379      P=0.088      P=0.488      P=0.166     |P=0.036N*    P=0.084      P=0.277N     P=0.477N     | 
|POLY 3             |     P=0.395      P=0.106      P=0.505      P=0.181     |P=0.031N*    P=0.086      P=0.245N     P=0.482N     | 
|POLY 1.5           |     P=0.394      P=0.106      P=0.503      P=0.182     |P=0.032N*    P=0.083      P=0.241N     P=0.489N     | 
|POLY 6             |     P=0.390      P=0.101      P=0.502      P=0.178     |P=0.030N*    P=0.091      P=0.252N     P=0.475N     | 
|LOGISTIC REGRESSION|     P=0.392      P=0.101      P=0.502      P=0.179     |P=0.051N     P=0.097      P=0.255N     P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.390      P=0.102      P=0.500      P=0.181     |P=0.036N*    P=0.080      P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.160      (e)          (e)          (e)         |P=0.040N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    8/50 (16%)   1/50 (2%)    7/50 (14%)  |2/50 (4%)    4/50 (8%)    6/50 (12%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/44.39      8/45.06      1/43.94      7/45.27     |2/44.80      4/45.09      6/45.40      1/47.23      | 
|POLY-3 PERCENT (g) |     4.5%         17.8%        2.3%         15.5%       |4.5%         8.9%         13.2%        2.1%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    1/33 (3%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     545          574          675          465         |717          433          401          670          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309      P=0.042 *    P=0.512N     P=0.078     |P=0.308N     P=0.326      P=0.120      P=0.477N     | 
|POLY 3             |     P=0.332      P=0.047 *    P=0.504N     P=0.083     |P=0.303N     P=0.340      P=0.137      P=0.482N     | 
|POLY 1.5           |     P=0.331      P=0.048 *    P=0.502N     P=0.083     |P=0.316N     P=0.338      P=0.136      P=0.489N     | 
|POLY 6             |     P=0.326      P=0.044 *    P=0.510N     P=0.081     |P=0.291N     P=0.343      P=0.135      P=0.475N     | 
|LOGISTIC REGRESSION|     P=0.331      P=0.041 *    P=0.496N     P=0.069     |P=0.468N     P=0.365      P=0.145      P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.329      P=0.046 *    P=0.500N     P=0.080     |P=0.340N     P=0.339      P=0.134      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.057      (e)          (e)          (e)         |P=0.158N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 58      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    2/48 (4%)    4/48 (8%)    4/50 (8%)   |2/50 (4%)    0/49 (0%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     3/44.40      2/43.81      4/43.68      4/44.51     |2/45.35      0/43.02      2/43.16      2/47.14      | 
|POLY-3 PERCENT (g) |     6.8%         4.6%         9.2%         9.0%        |4.4%         0.0%         4.6%         4.2%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/36 (0%)    1/33 (3%)    1/41 (2%)    | 
|FIRST INCIDENCE    |     545          555          561          465         |555          ---          615          693          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.271      P=0.490N     P=0.482      P=0.464     |P=0.371      P=0.250N     P=0.665      P=0.670N     | 
|POLY 3             |     P=0.287      P=0.506N     P=0.491      P=0.501     |P=0.369      P=0.249N     P=0.676      P=0.680N     | 
|POLY 1.5           |     P=0.293      P=0.504N     P=0.491      P=0.508     |P=0.359      P=0.247N     P=0.681      P=0.685N     | 
|POLY 6             |     P=0.278      P=0.518N     P=0.485      P=0.485     |P=0.378      P=0.251N     P=0.668      P=0.676N     | 
|LOGISTIC REGRESSION|     P=0.315      P=0.685N     P=0.486      P=0.495     |P=0.306      P=0.220N     P=0.694N     P=0.653      | 
|COCH-ARM / FISHERS |     P=0.299      P=0.510N     P=0.488      P=0.511     |P=0.340      P=0.253N     P=0.684      P=0.691N     | 
|ORDER RESTRICTED   |     P=0.427      (e)          (e)          (e)         |P=0.442      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/48 (0%)    0/48 (0%)    3/50 (6%)   |0/50 (0%)    1/49 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/43.39      0/42.74      0/42.88      3/44.01     |0/44.75      1/43.02      0/42.76      0/47.00      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         6.8%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    1/36 (3%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          651         |---          729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.063      P=0.557N     P=0.530N     P=0.272     |P=0.410N     P=0.495      (e)          (e)          | 
|POLY 3             |     P=0.069      P=0.503N     P=0.502N     P=0.310     |P=0.429N     P=0.492      (e)          (e)          | 
|POLY 1.5           |     P=0.070      P=0.502N     P=0.503N     P=0.313     |P=0.426N     P=0.493      (e)          (e)          | 
|POLY 6             |     P=0.070      P=0.508N     P=0.504N     P=0.304     |P=0.431N     P=0.492      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.072      (e)          (e)          P=0.312     |(e)          P=0.495      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.071      P=0.505N     P=0.505N     P=0.316     |P=0.422N     P=0.495      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.039 *    (e)          (e)          (e)         |P=0.364N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 59      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    11/50 (22%)  9/50 (18%)   6/50 (12%)  |                                                    | 
|POLY-3 RATE (b)    |     4/43.81      11/44.78     9/44.58      6/44.31     |                                                    | 
|POLY-3 PERCENT (g) |     9.1%         24.6%        20.2%        13.5%       |                                                    | 
|TERMINAL (d)       |     3/36 (8%)    5/27 (19%)   4/31 (13%)   2/28 (7%)   |                                                    | 
|FIRST INCIDENCE    |     706          619          647          651         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.519N     P=0.022 *    P=0.091      P=0.285     |                                                    | 
|POLY 3             |     P=0.436N     P=0.047 *    P=0.120      P=0.376     |                                                    | 
|POLY 1.5           |     P=0.438N     P=0.047 *    P=0.119      P=0.376     |                                                    | 
|POLY 6             |     P=0.440N     P=0.042 *    P=0.119      P=0.370     |                                                    | 
|LOGISTIC REGRESSION|     P=0.450N     P=0.044 *    P=0.115      P=0.367     |                                                    | 
|COCH-ARM / FISHERS |     P=0.445N     P=0.045 *    P=0.117      P=0.370     |                                                    | 
|ORDER RESTRICTED   |     P=0.150      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     1/43.72      1/44.36      1/44.26      3/44.48     |                                                    | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         2.3%         6.7%        |                                                    | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      555          566          482         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.155      P=0.741      P=0.751      P=0.279     |                                                    | 
|POLY 3             |     P=0.161      P=0.758N     P=0.758N     P=0.311     |                                                    | 
|POLY 1.5           |     P=0.161      P=0.757N     P=0.759N     P=0.311     |                                                    | 
|POLY 6             |     P=0.161      P=0.759      P=0.760N     P=0.307     |                                                    | 
|LOGISTIC REGRESSION|     P=0.157      P=0.736      P=0.761N     P=0.288     |                                                    | 
|COCH-ARM / FISHERS |     P=0.158      P=0.753N     P=0.753N     P=0.309     |                                                    | 
|ORDER RESTRICTED   |     P=0.193      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 60      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    1/49 (2%)    0/47 (0%)   |2/49 (4%)    1/48 (2%)    0/48 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/42.73      0/42.07      1/43.20      0/41.06     |2/44.66      1/42.82      0/41.58      0/45.23      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.3%         0.0%        |4.5%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/27 (0%)   |0/36 (0%)    0/35 (0%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          673          ---         |594          423          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.637      (e)          P=0.495      (e)         |P=0.104N     P=0.505N     P=0.247N     P=0.223N     | 
|POLY 3             |     P=0.630      (e)          P=0.502      (e)         |P=0.107N     P=0.515N     P=0.253N     P=0.234N     | 
|POLY 1.5           |     P=0.633      (e)          P=0.503      (e)         |P=0.107N     P=0.512N     P=0.248N     P=0.237N     | 
|POLY 6             |     P=0.623      (e)          P=0.499      (e)         |P=0.108N     P=0.518N     P=0.262N     P=0.233N     | 
|LOGISTIC REGRESSION|     P=0.637      (e)          P=0.506      (e)         |P=0.163N     P=0.388N     P=0.225N     P=0.346N     | 
|COCH-ARM / FISHERS |     P=0.636      (e)          P=0.505      (e)         |P=0.108N     P=0.508N     P=0.253N     P=0.253N     | 
|ORDER RESTRICTED   |     P=0.383      (e)          (e)          (e)         |P=0.073N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    2/48 (4%)    3/49 (6%)    0/47 (0%)   |1/49 (2%)    0/48 (0%)    2/48 (4%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     1/43.31      2/42.96      3/44.50      0/41.06     |1/44.31      0/42.02      2/42.81      1/45.55      | 
|POLY-3 PERCENT (g) |     2.3%         4.7%         6.7%         0.0%        |2.3%         0.0%         4.7%         2.2%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/31 (3%)    0/27 (0%)   |0/36 (0%)    0/35 (0%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     545          555          209          ---         |555          ---          514          644          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.321N     P=0.528      P=0.307      P=0.496N    |P=0.427      P=0.509N     P=0.500      P=0.748N     | 
|POLY 3             |     P=0.332N     P=0.497      P=0.315      P=0.511N    |P=0.437      P=0.511N     P=0.488      P=0.754N     | 
|POLY 1.5           |     P=0.325N     P=0.501      P=0.316      P=0.507N    |P=0.425      P=0.508N     P=0.491      P=0.758N     | 
|POLY 6             |     P=0.345N     P=0.486      P=0.308      P=0.518N    |P=0.450      P=0.512N     P=0.482      P=0.750N     | 
|LOGISTIC REGRESSION|     P=0.291N     P=0.334      P=0.320      P=0.558N    |P=0.216      P=0.444N     P=0.510      P=0.659      | 
|COCH-ARM / FISHERS |     P=0.319N     P=0.500      P=0.316      P=0.505N    |P=0.403      P=0.505N     P=0.492      P=0.747      | 
|ORDER RESTRICTED   |     P=0.200N     (e)          (e)          (e)         |P=0.376      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 61      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/48 (0%)    2/49 (4%)    1/47 (2%)   |1/49 (2%)    0/48 (0%)    0/48 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/42.73      0/42.07      2/43.97      1/41.06     |1/44.49      0/42.02      0/41.58      1/45.34      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.6%         2.4%        |2.3%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    1/31 (3%)    1/27 (4%)   |0/36 (0%)    0/35 (0%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          209          729 (T)     |462          ---          ---          703          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179      (e)          P=0.223      P=0.443     |P=0.532      P=0.508N     P=0.500N     P=0.753N     | 
|POLY 3             |     P=0.191      (e)          P=0.243      P=0.492     |P=0.534      P=0.511N     P=0.513N     P=0.756N     | 
|POLY 1.5           |     P=0.194      (e)          P=0.244      P=0.495     |P=0.529      P=0.509N     P=0.509N     P=0.760N     | 
|POLY 6             |     P=0.186      (e)          P=0.239      P=0.486     |P=0.539      P=0.513N     P=0.519N     P=0.753N     | 
|LOGISTIC REGRESSION|     P=0.194      (e)          P=0.283      P=0.443     |P=0.408      P=0.359N     P=0.485N     P=0.640      | 
|COCH-ARM / FISHERS |     P=0.196      (e)          P=0.253      P=0.495     |P=0.519      P=0.505N     P=0.505N     P=0.747      | 
|ORDER RESTRICTED   |     P=0.172      (e)          (e)          (e)         |P=0.402N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/47 (96%)  42/44 (95%)  41/43 (95%)  44/47 (94%) |43/47 (91%)  44/47 (94%)  43/43 (100%) 44/46 (96%)  | 
|POLY-3 RATE (b)    |     45/47.00     42/43.44     41/42.02     44/46.69    |43/47.00     44/46.13     43/43.00     44/46.00     | 
|POLY-3 PERCENT (g) |     95.7%        96.7%        97.6%        94.2%       |91.5%        95.4%        100.0%       95.7%        | 
|TERMINAL (d)       |     34/36 (94%)  26/27 (96%)  30/31 (97%)  26/28 (93%) |32/36 (89%)  34/36 (94%)  32/32 (100%) 38/40 (95%)  | 
|FIRST INCIDENCE    |     381          542          576          443         |423          423          401          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.236      P=0.170      P=0.496      P=0.149     |P=0.260N     P=0.471      P=0.248      P=0.324N     | 
|POLY 3             |     P=0.413N     P=0.627      P=0.545      P=0.556N    |P=0.249      P=0.366      P=0.072      P=0.348      | 
|POLY 1.5           |     P=0.407N     P=0.668      P=0.575      P=0.530N    |P=0.231      P=0.402      P=0.072      P=0.348      | 
|POLY 6             |     P=0.430N     P=0.576      P=0.539      P=0.597N    |P=0.258      P=0.350      P=0.072      P=0.348      | 
|LOGISTIC REGRESSION|     P=0.401N     P=0.662N     P=0.685N     P=0.492N    |P=0.204      P=0.487      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.390N     P=0.666N     P=0.657N     P=0.500N    |P=0.192      P=0.500      P=0.070      P=0.349      | 
|ORDER RESTRICTED   |     P=0.424N     (e)          (e)          (e)         |P=0.104      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 62      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    0/44 (0%)    1/43 (2%)    2/47 (4%)   |0/47 (0%)    0/47 (0%)    0/43 (0%)    0/46 (0%)    | 
|POLY-3 RATE (b)    |     1/42.29      0/39.82      1/39.66      2/41.73     |0/42.66      0/41.93      0/38.90      0/43.71      | 
|POLY-3 PERCENT (g) |     2.4%         0.0%         2.5%         4.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/36 (3%)    0/27 (0%)    1/31 (3%)    2/28 (7%)   |0/36 (0%)    0/36 (0%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.163      P=0.557N     P=0.728      P=0.412     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.197      P=0.512N     P=0.746      P=0.495     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.199      P=0.511N     P=0.744      P=0.499     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.194      P=0.516N     P=0.748      P=0.487     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.163      (e)          P=0.728      P=0.412     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.200      P=0.516N     P=0.730      P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.224      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Degeneration Cystic Focal                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/47 (4%)    0/44 (0%)    0/43 (0%)    0/47 (0%)   |0/47 (0%)    0/47 (0%)    0/43 (0%)    0/46 (0%)    | 
|POLY-3 RATE (b)    |     2/42.29      0/39.82      0/39.66      0/41.73     |0/42.66      0/41.93      0/38.90      0/43.71      | 
|POLY-3 PERCENT (g) |     4.7%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/36 (6%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/36 (0%)    0/36 (0%)    0/32 (0%)    0/40 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.189N     P=0.303N     P=0.272N     P=0.295N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.172N     P=0.250N     P=0.251N     P=0.240N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.173N     P=0.250N     P=0.254N     P=0.238N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.168N     P=0.254N     P=0.250N     P=0.245N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.189N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.174N     P=0.264N     P=0.270N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.030N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 63      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Mineralization Focal                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/47 (96%)  43/44 (98%)  42/43 (98%)  42/47 (89%) |25/47 (53%)  26/47 (55%)  40/43 (93%)  44/46 (96%)  | 
|POLY-3 RATE (b)    |     45/45.81     43/44.00     42/42.79     42/45.35    |25/42.75     26/43.33     40/41.69     44/45.28     | 
|POLY-3 PERCENT (g) |     98.2%        97.7%        98.1%        92.6%       |58.5%        60.0%        96.0%        97.2%        | 
|TERMINAL (d)       |     36/36 (100%) 26/27 (96%)  31/31 (100%) 27/28 (96%) |23/36 (64%)  23/36 (64%)  31/32 (97%)  39/40 (98%)  | 
|FIRST INCIDENCE    |     469          542          209          443         |717          433          511          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.377      P=0.107      P=0.390      P=0.188     |P<0.001 **   P=0.490      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.075N     P=0.737N     P=0.819N     P=0.176N    |P<0.001 **   P=0.530      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.061N     P=0.739      P=0.730      P=0.175N    |P<0.001 **   P=0.513      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.133N     P=0.655N     P=0.847N     P=0.223N    |P<0.001 **   P=0.558      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.068N     P=0.712      P=0.498      P=0.159N    |P<0.001 **   P=0.460      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.068N     P=0.525      P=0.534      P=0.217N    |P<0.001 **   P=0.500      P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.062N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/47 (9%)    13/44 (30%)  33/43 (77%)  40/47 (85%) |3/47 (6%)    7/47 (15%)   27/43 (63%)  42/46 (91%)  | 
|POLY-3 RATE (b)    |     4/42.29      13/41.13     33/42.30     40/45.49    |3/43.47      7/42.78      27/40.15     42/45.28     | 
|POLY-3 PERCENT (g) |     9.5%         31.6%        78.0%        87.9%       |6.9%         16.4%        67.3%        92.8%        | 
|TERMINAL (d)       |     4/36 (11%)   9/27 (33%)   25/31 (81%)  27/28 (96%) |2/36 (6%)    5/36 (14%)   23/32 (72%)  37/40 (93%)  | 
|FIRST INCIDENCE    |     729 (T)      555          209          443         |423          433          511          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **  |P<0.001 **   P=0.160      P<0.001 **   P<0.001 **   | 
|POLY 3             |     P<0.001 **   P=0.010 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.150      P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P<0.001 **   P=0.010 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.152      P<0.001 **   P<0.001 **   | 
|POLY 6             |     P<0.001 **   P=0.010 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.149      P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.170      P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.010 *    P<0.001 **   P<0.001 **  |P<0.001 **   P=0.158      P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 64      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth: Peridontal Tissue                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     0/1 (0%)     0/1 (0%)     0/0 (0%)    |0/0 (0%)     1/2 (50%)    2/2 (100%)   0/1 (0%)     | 
|POLY-3 RATE (b)    |     0/0.00       0/0.44       0/1.00       0/0.00      |0/0.00       1/2.00       2/2.00       0/0.66       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         50.0%        100.0%       0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/1 (0%)     0/0 (0%)    |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          423          587          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.550N     P=0.500      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.539N     P=1.000      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/47 (0%)    2/50 (4%)   |0/50 (0%)    0/48 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.19      0/43.20      0/42.25      2/44.29     |0/44.75      0/42.02      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/35 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          562         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.046 *    (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.045 *    (e)          (e)          P=0.243     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.245     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.044 *    (e)          (e)          P=0.238     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.047 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.258     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.031 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 65      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    2/47 (4%)    0/50 (0%)   |0/50 (0%)    0/48 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.19      0/43.20      2/42.84      0/43.44     |0/44.75      0/42.02      0/43.24      0/47.00      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/36 (0%)    0/27 (0%)    0/31 (0%)    0/28 (0%)   |0/37 (0%)    0/35 (0%)    0/33 (0%)    0/41 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          566          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.508      (e)          P=0.237      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.508      (e)          P=0.235      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.517      (e)          P=0.234      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.495      (e)          P=0.235      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.542      (e)          P=0.241      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.528      (e)          P=0.242      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.245      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |16/50 (32%)  7/50 (14%)   16/49 (33%)  11/50 (22%)  | 
|POLY-3 RATE (b)    |                                                        |16/46.01     7/44.04      16/43.88     11/47.59     | 
|POLY-3 PERCENT (g) |                                                        |34.8%        15.9%        36.5%        23.1%        | 
|TERMINAL (d)       |                                                        |12/37 (32%)  5/36 (14%)   12/32 (38%)  10/41 (24%)  | 
|FIRST INCIDENCE    |                                                        |566          636          401          542          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.414N     P=0.040N*    P=0.420      P=0.124N     | 
|POLY 3             |                                                        |P=0.444N     P=0.032N*    P=0.521      P=0.154N     | 
|POLY 1.5           |                                                        |P=0.473N     P=0.030N*    P=0.542      P=0.163N     | 
|POLY 6             |                                                        |P=0.423N     P=0.036N*    P=0.482      P=0.149N     | 
|LOGISTIC REGRESSION|                                                        |P=0.488N     P=0.031N*    P=0.535      P=0.166N     | 
|COCH-ARM / FISHERS |                                                        |P=0.530N     P=0.028N*    P=0.558      P=0.184N     | 
|ORDER RESTRICTED   |                                                        |P=0.149N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/27/03                           EXPERIMENT: 96010 TEST: 03                                            Page 66      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -      WATER DISINFECTION BYPRODUCTS (SODIUM             
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       125 MG/L     1000MG/L     2000MG/L    |0 MG/L       125 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Vagina                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/6 (33%)    1/3 (33%)    1/3 (33%)    1/1 (100%)   | 
|POLY-3 RATE (b)    |                                                        |2/5.07       1/2.46       1/2.23       1/1.00       | 
|POLY-3 PERCENT (g) |                                                        |39.4%        40.6%        44.9%        100.0%       | 
|TERMINAL (d)       |                                                        |2/2 (100%)   1/2 (50%)    1/1 (100%)   1/1 (100%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.545      P=0.500N     P=1.000N     P=1.000N     | 
|POLY 3             |                                                        |P=0.333      P=0.755      P=0.729      P=0.494      | 
|POLY 1.5           |                                                        |P=0.322      P=0.751      P=0.735      P=0.468      | 
|POLY 6             |                                                        |P=0.361      P=0.766      P=0.724      P=0.538      | 
|LOGISTIC REGRESSION|                                                        |P=0.545      P=0.500N     P=1.000N     P=1.000N     | 
|COCH-ARM / FISHERS |                                                        |P=0.301      P=0.762      P=0.762      P=0.429      | 
|ORDER RESTRICTED   |                                                        |P=0.382      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    

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