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TDMS Study 96010-04 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Southern Research Inst              WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                            DATE: 03/31/03  
EXPERIMENT: 96010 TEST: 04                                                                                        TIME: 10:16:32    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96010A     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: SOUTHERN RESEARCH INSTITUTE                      WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)             DATE: 03/31/03    
EXPERIMENT: 96010 TEST: 04                                                                                        TIME: 10:35:32    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  96010A      
CONT: N01-ES-85420                                                                                                CAS: 7775-09-9    
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                              CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                          
==================================================================================================================================  
           0 MG/L                     500 MG/L                           1000MG/L                           2000MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4     3.6    28.1       4.0     27.7    1.11       72      3.8     28.2    1.06      136      3.9     28.2    1.08      274       
  8     3.3    33.9       3.6     33.3    1.09       54      3.3     33.5    1.00      100      3.3     33.8    1.00      197       
 12     3.1    38.7       3.3     38.2    1.06       43      3.0     38.4    0.97       78      3.3     38.6    1.06      171       
 16     3.2    43.6       3.2     43.0    1.00       37      3.1     43.5    0.97       71      2.9     43.6    0.91      134       
 20     2.8    47.1       2.9     46.5    1.04       31      2.9     47.4    1.04       61      2.8     47.0    1.00      120       
 24     3.0    49.5       3.0     48.8    1.00       31      3.0     49.1    1.00       61      3.1     49.6    1.03      125       
 28     3.4    50.5       3.3     49.8    0.97       33      3.3     49.9    0.97       67      3.4     50.2    1.00      135       
 32     3.3    50.7       3.3     49.7    1.00       33      3.3     49.8    1.00       67      3.4     50.4    1.03      137       
 36     3.5    51.3       3.6     50.7    1.03       35      3.6     50.6    1.03       72      3.6     51.2    1.03      141       
 40     3.8    51.8       3.7     51.1    0.97       37      4.0     51.4    1.05       79      3.8     51.8    1.00      145       
 44     3.7    52.2       3.7     50.9    1.00       36      3.6     51.3    0.97       71      3.7     52.1    1.00      140       
 48     3.9    53.0       3.7     51.8    0.95       36      3.8     51.7    0.97       73      3.8     52.8    0.97      142       
 52     3.8    52.6       3.6     51.8    0.95       34      3.7     52.1    0.97       71      3.7     52.9    0.97      140       
 56     4.1    52.7       3.9     52.1    0.95       38      4.0     52.2    0.98       76      4.0     52.5    0.98      151       
 60     4.1    53.0       4.1     52.2    1.00       39      4.3     52.6    1.05       81      4.0     53.0    0.98      152       
 64     4.2    53.4       4.2     53.2    1.00       39      4.5     52.7    1.07       85      4.2     53.4    1.00      157       
 68     4.2    53.2       4.3     53.5    1.02       40      4.3     53.2    1.02       81      4.2     54.5    1.00      153       
 72     3.8    54.1       4.0     53.4    1.05       37      4.0     52.8    1.05       75      3.9     54.2    1.03      144       
 76     3.9    53.6       4.0     53.0    1.03       38      4.1     52.2    1.05       79      4.0     54.0    1.03      149       
 80     4.2    52.5       4.0     52.4    0.95       39      4.4     51.8    1.05       84      4.1     52.9    0.98      155       
 84     4.1    53.0       4.2     52.4    1.02       40      4.1     53.0    1.00       77      4.1     51.7    1.00      157       
 88     4.1    51.7       3.9     51.4    0.95       38      3.9     52.3    0.95       74      3.9     50.6    0.95      156       
 92     4.9    50.9       4.3     50.6    0.88       43      4.3     51.4    0.88       83      4.2     49.6    0.86      169       
 96     4.8    50.7       4.3     49.7    0.90       43      4.0     50.3    0.83       80      4.1     49.6    0.85      164       
100     4.3    48.6       4.0     47.1    0.93       43      3.8     48.1    0.88       79      3.9     48.1    0.91      161       
104     4.2    46.6       4.2     45.1    1.00       46      4.1     46.5    0.98       89      4.0     48.5    0.95      166       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.4    33.6       3.6     33.1    1.09       57      3.4     33.3    1.01      105      3.5     33.5    1.05      214       
SD(D)   0.2               0.3             0.02       14      0.4             0.04       29      0.3             0.04       54       
CV(E)   7.2               9.3             2.1      25.4     12.5             4.4      28.1      9.1             4.2      25.0       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    3.5    50.2       3.4     49.4    0.99       34      3.4     49.7    1.00       69      3.4     50.2    0.99      136       
SD(D)   0.4               0.3             0.03        2      0.4             0.03        5      0.3             0.04        8       
CV(E)  10.8               9.1             3.0       6.6     10.8             3.1       7.9     10.2             3.8       5.8       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    4.2    51.8       4.1     51.2    0.98       40      4.1     51.5    0.98       80      4.0     51.7    0.96      156       
SD(D)   0.3               0.1             0.05        3      0.2             0.08        4      0.1             0.06        7       
CV(E)   7.0               3.5             5.5       6.7      4.8             7.9       5.3      2.7             5.9       4.6       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                              CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                          
==================================================================================================================================  
           0 MG/L                     500 MG/L                           1000MG/L                           2000MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  4     3.5    22.3       3.4     22.2     0.97      78      3.4     22.4     0.97     151      3.9     22.0     1.11     356       
  8     2.9    27.3       3.1     26.6     1.07      58      3.2     27.1     1.10     117      3.5     26.3     1.21     266       
 12     3.1    32.0       3.2     31.4     1.03      51      3.1     31.6     1.00      98      3.5     30.2     1.13     234       
 16     3.0    36.5       3.1     35.9     1.03      43      3.6     36.0     1.20     100      3.1     35.0     1.03     175       
 20     2.4    42.3       2.4     41.9     1.00      29      2.4     42.3     1.00      57      2.5     41.2     1.04     123       
 24     2.5    46.9       2.3     46.5     0.92      25      2.3     46.8     0.92      50      2.4     45.1     0.96     106       
 28     2.4    49.9       2.7     49.7     1.13      27      2.3     50.3     0.96      46      2.9     48.6     1.21     118       
 32     2.5    52.5       2.4     51.9     0.96      23      2.4     52.7     0.96      45      2.4     51.4     0.96      93       
 36     2.3    54.4       2.5     54.2     1.09      23      2.3     54.3     1.00      43      2.5     53.0     1.09      94       
 40     2.3    57.8       2.3     58.0     1.00      20      2.2     57.4     0.96      39      2.4     56.1     1.04      87       
 44     2.5    58.4       2.7     58.5     1.08      23      2.4     57.2     0.96      42      2.8     56.6     1.12      99       
 48     2.3    60.2       2.4     59.6     1.04      20      2.4     58.6     1.04      41      2.7     59.0     1.17      90       
 52     2.4    61.0       2.4     60.8     1.00      19      2.4     59.9     1.00      40      2.5     60.5     1.04      82       
 56     2.5    61.2       2.5     61.0     1.00      20      2.5     60.1     1.00      42      2.6     61.4     1.04      83       
 60     2.6    62.2       2.6     61.1     1.00      22      2.8     60.9     1.08      46      2.8     62.1     1.08      89       
 64     2.8    62.8       2.7     62.4     0.96      22      2.7     62.7     0.96      43      3.2     62.0     1.14     103       
 68     2.6    63.4       2.7     62.3     1.04      21      2.8     62.9     1.08      44      2.5     63.7     0.96      80       
 72     2.4    64.2       2.8     61.8     1.17      23      2.5     63.1     1.04      40      2.7     64.5     1.13      84       
 76     2.7    65.0       2.8     63.9     1.04      22      2.9     64.3     1.07      44      2.8     64.6     1.04      86       
 80     2.9    66.5       2.8     64.7     0.97      22      3.0     65.0     1.03      46      2.9     65.2     1.00      89       
 84     2.8    65.7       2.8     64.9     1.00      22      3.1     64.3     1.11      49      2.8     65.1     1.00      87       
 88     2.6    65.9       3.0     62.9     1.15      24      3.3     61.7     1.27      54      2.7     63.7     1.04      86       
 92     3.1    64.9       3.8     60.2     1.23      32      3.7     62.3     1.19      60      3.0     61.9     0.97      96       
 96     3.2    64.3       3.5     57.8     1.09      30      4.0     60.1     1.25      67      3.2     58.5     1.00     110       
100     3.4    63.3       4.2     56.3     1.24      37      4.5     57.3     1.32      79      3.4     58.6     1.00     116       
104     3.6    61.0       3.7     53.7     1.03      35      5.1     55.0     1.42      93      4.1     54.6     1.14     150       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    3.2    27.2       3.2     26.7     1.02      62      3.2     27.0     1.02     122      3.6     26.2     1.15     285       
SD(D)   0.3               0.2              0.05      14      0.2              0.07      27      0.2              0.05      63       
CV(E)   9.1               5.8              4.8     22.3      4.8              6.8     22.0      6.4              4.3     22.2       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    2.5    52.0       2.5     51.7     1.02      25      2.5     51.6     1.00      50      2.6     50.7     1.07     107       
SD(D)   0.2               0.2              0.06       7      0.4              0.08      18      0.2              0.08      27       
CV(E)   7.9               9.6              6.0     27.4     15.9              7.8     36.3      8.8              7.7     25.6       
> 52 WEEKS                                                                                                                          
----------------                                                                                                                    
MEAN    2.9    63.9       3.1     61.0     1.07      25      3.3     61.5     1.14      54      3.0     62.0     1.04      97       
SD(D)   0.4               0.5              0.10       6      0.8              0.14      16      0.4              0.06      19       
CV(E)  12.5              17.6              8.9     22.8     24.6             12.0     29.9     14.1              6.0     20.0       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                DIAGNOSTIC TRAILER REPORT                                                                                           
                WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                  
                CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                        
=========================================================================================================                           
           0 MG/L                  500 MG/L                 1000MG/L                 2000MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               22.2  50                 22.4  50                 22.2  50                 22.3  50                               
  1               22.2  50                 22.4  50                 22.2  50                 22.3  50                               
  4   3.6  8015   28.1  50     4.0  7907   27.7  50     3.8  8065   28.2  50     3.9  8165   28.2  50                               
  8   3.3  8155   33.9  50     3.6  7756   33.3  50     3.3  7906   33.5  50     3.3  7952   33.8  50                               
 12   3.1  8196   38.7  50     3.3  7761   38.2  50     3.0  7731   38.4  50     3.3  7839   38.6  50                               
 16   3.2  3498   43.6  50     3.2  3503   43.0  50     3.1  3519   43.5  50     2.9  8109   43.6  50                               
 20   2.8  8154   47.1  50     2.9  8290   46.5  50     2.9  8135   47.4  50     2.8  8294   47.0  50                               
 24   3.0  8283   49.5  50     3.0  8300   48.8  50     3.0  8181   49.1  50     3.1  8188   49.6  50                               
 28   3.4  8026   50.5  50     3.3  8113   49.8  50     3.3  8092   49.9  50     3.4  7925   50.2  50                               
 32   3.3  8252   50.7  50     3.3  8073   49.7  50     3.3  8110   49.8  50     3.4  8141   50.4  50                               
 36   3.5  8179   51.3  50     3.6  8132   50.7  50     3.6  7950   50.6  50     3.6  8161   51.2  50                               
 40   3.8  3426   51.8  50     3.7  3554   51.1  50     4.0  3481   51.4  50     3.8  3441   51.8  50                               
 44   3.7  7963   52.2  49     3.7  8002   50.9  50     3.6  7898   51.3  50     3.7  7705   52.1  49                               
 48   3.9  8160   53.0  49     3.7  8353   51.8  50     3.8  8210   51.7  50     3.8  7952   52.8  49                               
 52   3.8  8073   52.6  49     3.6  8269   51.8  50     3.7  8270   52.1  50     3.7  7960   52.9  49                               
 56   4.1  7781   52.7  49     3.9  8284   52.1  50     4.0  8331   52.2  50     4.0  8145   52.5  49                               
 60   4.1  7508   53.0  49     4.1  8165   52.2  50     4.3  8046   52.6  50     4.0  7966   53.0  49                               
 64   4.2  7514   53.4  49     4.2  8147   53.2  49     4.5  8223   52.7  50     4.2  8053   53.4  49                               
 68   4.2  7276   53.2  49     4.3  7978   53.5  49     4.3  7815   53.2  50     4.2  7661   54.5  48                               
 72   3.8  7581   54.1  48     4.0  7995   53.4  49     4.0  7871   52.8  50     3.9  7804   54.2  48                               
 76   3.9  7449   53.6  48     4.0  7848   53.0  49     4.1  7879   52.2  50     4.0  7625   54.0  48                               
 80   4.2  7388   52.5  48     4.0  7955   52.4  49     4.4  7749   51.8  49     4.1  7442   52.9  47                               
 84   4.1  6973   53.0  45     4.2  7590   52.4  47     4.1  7420   53.0  46     4.1  7395   51.7  46                               
 88   4.1  7034   51.7  44     3.9  7352   51.4  46     3.9  7275   52.3  45     3.9  6878   50.6  44                               
 92   4.9  6547   50.9  41     4.3  7301   50.6  46     4.3  7100   51.4  45     4.2  6688   49.6  42                               
 96   4.8  6479   50.7  39     4.3  7381   49.7  45     4.0  6817   50.3  44     4.1  6121   49.6  37                               
100   4.3  6284   48.6  39     4.0  7070   47.1  45     3.8  6651   48.1  41     3.9  5877   48.1  36                               
104   4.2  5882   46.6  38     4.2  6358   45.1  41     4.1  6451   46.5  41     4.0  5070   48.5  33                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           30.7                     30.4                     30.6                     30.7                                   
14 TO 52          50.2                     49.4                     49.7                     50.2                                   
 > 52             51.8                     51.2                     51.5                     51.7                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                DIAGNOSTIC TRAILER REPORT                                                                                           
                WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                
                CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                                        
=========================================================================================================                           
           0 MG/L                  500 MG/L                 1000MG/L                 2000MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               18.4  50                 18.2  50                 18.4  50                 18.3  50                               
  1               18.4  50                 18.2  50                 18.4  50                 18.3  50                               
  4   3.5  7743   22.3  50     3.4  8018   22.2  50     3.4  8117   22.4  50     3.9  8275   22.0  50                               
  8   2.9  7515   27.3  50     3.1  7760   26.6  50     3.2  7547   27.1  48     3.5  7253   26.3  50                               
 12   3.1  8290   32.0  50     3.2  7839   31.4  50     3.1  7383   31.6  48     3.5  7652   30.2  50                               
 16   3.0  2936   36.5  50     3.1  2821   35.9  50     3.6  2902   36.0  48     3.1  7785   35.0  50                               
 20   2.4  6563   42.3  50     2.4  7841   41.9  50     2.4  7174   42.3  48     2.5  7369   41.2  50                               
 24   2.5  7912   46.9  50     2.3  7366   46.5  50     2.3  7006   46.8  48     2.4  7594   45.1  49                               
 28   2.4  7879   49.9  50     2.7  7288   49.7  50     2.3  7445   50.3  48     2.9  6499   48.6  49                               
 32   2.5  7837   52.5  50     2.4  8154   51.9  50     2.4  7716   52.7  48     2.4  8036   51.4  49                               
 36   2.3  7916   54.4  50     2.5  7187   54.2  50     2.3  7190   54.3  48     2.5  7647   53.0  49                               
 40   2.3  3420   57.8  49     2.3  3495   58.0  50     2.2  3432   57.4  48     2.4  3430   56.1  49                               
 44   2.5  7371   58.4  49     2.7  7955   58.5  50     2.4  5946   57.2  48     2.8  7689   56.6  49                               
 48   2.3  8142   60.2  49     2.4  8373   59.6  50     2.4  7490   58.6  48     2.7  7825   59.0  49                               
 52   2.4  8147   61.0  49     2.4  7887   60.8  50     2.4  7935   59.9  48     2.5  7557   60.5  49                               
 56   2.5  8193   61.2  49     2.5  8269   61.0  50     2.5  7962   60.1  48     2.6  8109   61.4  49                               
 60   2.6  8084   62.2  49     2.6  8149   61.1  50     2.8  6633   60.9  48     2.8  7062   62.1  49                               
 64   2.8  7724   62.8  48     2.7  7909   62.4  50     2.7  7748   62.7  48     3.2  7423   62.0  49                               
 68   2.6  8001   63.4  48     2.7  7900   62.3  49     2.8  7886   62.9  48     2.5  7419   63.7  47                               
 72   2.4  8053   64.2  48     2.8  7989   61.8  48     2.5  7740   63.1  47     2.7  7353   64.5  46                               
 76   2.7  7796   65.0  47     2.8  7688   63.9  47     2.9  7392   64.3  45     2.8  7480   64.6  46                               
 80   2.9  7788   66.5  47     2.8  7597   64.7  46     3.0  6934   65.0  44     2.9  7094   65.2  44                               
 84   2.8  7595   65.7  46     2.8  6700   64.9  44     3.1  7098   64.3  43     2.8  7234   65.1  44                               
 88   2.6  6809   65.9  41     3.0  6908   62.9  44     3.3  6635   61.7  42     2.7  7031   63.7  43                               
 92   3.1  6591   64.9  39     3.8  7094   60.2  44     3.7  6262   62.3  39     3.0  6941   61.9  42                               
 96   3.2  5381   64.3  38     3.5  6712   57.8  44     4.0  5826   60.1  37     3.2  6758   58.5  41                               
100   3.4  5770   63.3  37     4.2  6493   56.3  41     4.5  5863   57.3  36     3.4  5862   58.6  36                               
104   3.6  5759   61.0  36     3.7  5211   53.7  36     5.1  4909   55.0  31     4.1  5484   54.6  35                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           25.0                     24.6                     24.9                     24.2                                   
14 TO 52          52.0                     51.7                     51.6                     50.7                                   
 > 52             63.9                     61.0                     61.5                     62.0                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              

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