TDMS Study 96010-04 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) DATE: 03/31/03
EXPERIMENT: 96010 TEST: 04 TIME: 10:16:32
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C96010A
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: SOUTHERN RESEARCH INSTITUTE WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) DATE: 03/31/03
EXPERIMENT: 96010 TEST: 04 TIME: 10:35:32
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: 96010A
CONT: N01-ES-85420 CAS: 7775-09-9
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
==================================================================================================================================
0 MG/L 500 MG/L 1000MG/L 2000MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 3.6 28.1 4.0 27.7 1.11 72 3.8 28.2 1.06 136 3.9 28.2 1.08 274
8 3.3 33.9 3.6 33.3 1.09 54 3.3 33.5 1.00 100 3.3 33.8 1.00 197
12 3.1 38.7 3.3 38.2 1.06 43 3.0 38.4 0.97 78 3.3 38.6 1.06 171
16 3.2 43.6 3.2 43.0 1.00 37 3.1 43.5 0.97 71 2.9 43.6 0.91 134
20 2.8 47.1 2.9 46.5 1.04 31 2.9 47.4 1.04 61 2.8 47.0 1.00 120
24 3.0 49.5 3.0 48.8 1.00 31 3.0 49.1 1.00 61 3.1 49.6 1.03 125
28 3.4 50.5 3.3 49.8 0.97 33 3.3 49.9 0.97 67 3.4 50.2 1.00 135
32 3.3 50.7 3.3 49.7 1.00 33 3.3 49.8 1.00 67 3.4 50.4 1.03 137
36 3.5 51.3 3.6 50.7 1.03 35 3.6 50.6 1.03 72 3.6 51.2 1.03 141
40 3.8 51.8 3.7 51.1 0.97 37 4.0 51.4 1.05 79 3.8 51.8 1.00 145
44 3.7 52.2 3.7 50.9 1.00 36 3.6 51.3 0.97 71 3.7 52.1 1.00 140
48 3.9 53.0 3.7 51.8 0.95 36 3.8 51.7 0.97 73 3.8 52.8 0.97 142
52 3.8 52.6 3.6 51.8 0.95 34 3.7 52.1 0.97 71 3.7 52.9 0.97 140
56 4.1 52.7 3.9 52.1 0.95 38 4.0 52.2 0.98 76 4.0 52.5 0.98 151
60 4.1 53.0 4.1 52.2 1.00 39 4.3 52.6 1.05 81 4.0 53.0 0.98 152
64 4.2 53.4 4.2 53.2 1.00 39 4.5 52.7 1.07 85 4.2 53.4 1.00 157
68 4.2 53.2 4.3 53.5 1.02 40 4.3 53.2 1.02 81 4.2 54.5 1.00 153
72 3.8 54.1 4.0 53.4 1.05 37 4.0 52.8 1.05 75 3.9 54.2 1.03 144
76 3.9 53.6 4.0 53.0 1.03 38 4.1 52.2 1.05 79 4.0 54.0 1.03 149
80 4.2 52.5 4.0 52.4 0.95 39 4.4 51.8 1.05 84 4.1 52.9 0.98 155
84 4.1 53.0 4.2 52.4 1.02 40 4.1 53.0 1.00 77 4.1 51.7 1.00 157
88 4.1 51.7 3.9 51.4 0.95 38 3.9 52.3 0.95 74 3.9 50.6 0.95 156
92 4.9 50.9 4.3 50.6 0.88 43 4.3 51.4 0.88 83 4.2 49.6 0.86 169
96 4.8 50.7 4.3 49.7 0.90 43 4.0 50.3 0.83 80 4.1 49.6 0.85 164
100 4.3 48.6 4.0 47.1 0.93 43 3.8 48.1 0.88 79 3.9 48.1 0.91 161
104 4.2 46.6 4.2 45.1 1.00 46 4.1 46.5 0.98 89 4.0 48.5 0.95 166
1 TO 13 WEEKS
----------------
MEAN 3.4 33.6 3.6 33.1 1.09 57 3.4 33.3 1.01 105 3.5 33.5 1.05 214
SD(D) 0.2 0.3 0.02 14 0.4 0.04 29 0.3 0.04 54
CV(E) 7.2 9.3 2.1 25.4 12.5 4.4 28.1 9.1 4.2 25.0
14 TO 52 WEEKS
----------------
MEAN 3.5 50.2 3.4 49.4 0.99 34 3.4 49.7 1.00 69 3.4 50.2 0.99 136
SD(D) 0.4 0.3 0.03 2 0.4 0.03 5 0.3 0.04 8
CV(E) 10.8 9.1 3.0 6.6 10.8 3.1 7.9 10.2 3.8 5.8
> 52 WEEKS
----------------
MEAN 4.2 51.8 4.1 51.2 0.98 40 4.1 51.5 0.98 80 4.0 51.7 0.96 156
SD(D) 0.3 0.1 0.05 3 0.2 0.08 4 0.1 0.06 7
CV(E) 7.0 3.5 5.5 6.7 4.8 7.9 5.3 2.7 5.9 4.6
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
==================================================================================================================================
0 MG/L 500 MG/L 1000MG/L 2000MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 3.5 22.3 3.4 22.2 0.97 78 3.4 22.4 0.97 151 3.9 22.0 1.11 356
8 2.9 27.3 3.1 26.6 1.07 58 3.2 27.1 1.10 117 3.5 26.3 1.21 266
12 3.1 32.0 3.2 31.4 1.03 51 3.1 31.6 1.00 98 3.5 30.2 1.13 234
16 3.0 36.5 3.1 35.9 1.03 43 3.6 36.0 1.20 100 3.1 35.0 1.03 175
20 2.4 42.3 2.4 41.9 1.00 29 2.4 42.3 1.00 57 2.5 41.2 1.04 123
24 2.5 46.9 2.3 46.5 0.92 25 2.3 46.8 0.92 50 2.4 45.1 0.96 106
28 2.4 49.9 2.7 49.7 1.13 27 2.3 50.3 0.96 46 2.9 48.6 1.21 118
32 2.5 52.5 2.4 51.9 0.96 23 2.4 52.7 0.96 45 2.4 51.4 0.96 93
36 2.3 54.4 2.5 54.2 1.09 23 2.3 54.3 1.00 43 2.5 53.0 1.09 94
40 2.3 57.8 2.3 58.0 1.00 20 2.2 57.4 0.96 39 2.4 56.1 1.04 87
44 2.5 58.4 2.7 58.5 1.08 23 2.4 57.2 0.96 42 2.8 56.6 1.12 99
48 2.3 60.2 2.4 59.6 1.04 20 2.4 58.6 1.04 41 2.7 59.0 1.17 90
52 2.4 61.0 2.4 60.8 1.00 19 2.4 59.9 1.00 40 2.5 60.5 1.04 82
56 2.5 61.2 2.5 61.0 1.00 20 2.5 60.1 1.00 42 2.6 61.4 1.04 83
60 2.6 62.2 2.6 61.1 1.00 22 2.8 60.9 1.08 46 2.8 62.1 1.08 89
64 2.8 62.8 2.7 62.4 0.96 22 2.7 62.7 0.96 43 3.2 62.0 1.14 103
68 2.6 63.4 2.7 62.3 1.04 21 2.8 62.9 1.08 44 2.5 63.7 0.96 80
72 2.4 64.2 2.8 61.8 1.17 23 2.5 63.1 1.04 40 2.7 64.5 1.13 84
76 2.7 65.0 2.8 63.9 1.04 22 2.9 64.3 1.07 44 2.8 64.6 1.04 86
80 2.9 66.5 2.8 64.7 0.97 22 3.0 65.0 1.03 46 2.9 65.2 1.00 89
84 2.8 65.7 2.8 64.9 1.00 22 3.1 64.3 1.11 49 2.8 65.1 1.00 87
88 2.6 65.9 3.0 62.9 1.15 24 3.3 61.7 1.27 54 2.7 63.7 1.04 86
92 3.1 64.9 3.8 60.2 1.23 32 3.7 62.3 1.19 60 3.0 61.9 0.97 96
96 3.2 64.3 3.5 57.8 1.09 30 4.0 60.1 1.25 67 3.2 58.5 1.00 110
100 3.4 63.3 4.2 56.3 1.24 37 4.5 57.3 1.32 79 3.4 58.6 1.00 116
104 3.6 61.0 3.7 53.7 1.03 35 5.1 55.0 1.42 93 4.1 54.6 1.14 150
1 TO 13 WEEKS
----------------
MEAN 3.2 27.2 3.2 26.7 1.02 62 3.2 27.0 1.02 122 3.6 26.2 1.15 285
SD(D) 0.3 0.2 0.05 14 0.2 0.07 27 0.2 0.05 63
CV(E) 9.1 5.8 4.8 22.3 4.8 6.8 22.0 6.4 4.3 22.2
14 TO 52 WEEKS
----------------
MEAN 2.5 52.0 2.5 51.7 1.02 25 2.5 51.6 1.00 50 2.6 50.7 1.07 107
SD(D) 0.2 0.2 0.06 7 0.4 0.08 18 0.2 0.08 27
CV(E) 7.9 9.6 6.0 27.4 15.9 7.8 36.3 8.8 7.7 25.6
> 52 WEEKS
----------------
MEAN 2.9 63.9 3.1 61.0 1.07 25 3.3 61.5 1.14 54 3.0 62.0 1.04 97
SD(D) 0.4 0.5 0.10 6 0.8 0.14 16 0.4 0.06 19
CV(E) 12.5 17.6 8.9 22.8 24.6 12.0 29.9 14.1 6.0 20.0
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
=========================================================================================================
0 MG/L 500 MG/L 1000MG/L 2000MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 22.2 50 22.4 50 22.2 50 22.3 50
1 22.2 50 22.4 50 22.2 50 22.3 50
4 3.6 8015 28.1 50 4.0 7907 27.7 50 3.8 8065 28.2 50 3.9 8165 28.2 50
8 3.3 8155 33.9 50 3.6 7756 33.3 50 3.3 7906 33.5 50 3.3 7952 33.8 50
12 3.1 8196 38.7 50 3.3 7761 38.2 50 3.0 7731 38.4 50 3.3 7839 38.6 50
16 3.2 3498 43.6 50 3.2 3503 43.0 50 3.1 3519 43.5 50 2.9 8109 43.6 50
20 2.8 8154 47.1 50 2.9 8290 46.5 50 2.9 8135 47.4 50 2.8 8294 47.0 50
24 3.0 8283 49.5 50 3.0 8300 48.8 50 3.0 8181 49.1 50 3.1 8188 49.6 50
28 3.4 8026 50.5 50 3.3 8113 49.8 50 3.3 8092 49.9 50 3.4 7925 50.2 50
32 3.3 8252 50.7 50 3.3 8073 49.7 50 3.3 8110 49.8 50 3.4 8141 50.4 50
36 3.5 8179 51.3 50 3.6 8132 50.7 50 3.6 7950 50.6 50 3.6 8161 51.2 50
40 3.8 3426 51.8 50 3.7 3554 51.1 50 4.0 3481 51.4 50 3.8 3441 51.8 50
44 3.7 7963 52.2 49 3.7 8002 50.9 50 3.6 7898 51.3 50 3.7 7705 52.1 49
48 3.9 8160 53.0 49 3.7 8353 51.8 50 3.8 8210 51.7 50 3.8 7952 52.8 49
52 3.8 8073 52.6 49 3.6 8269 51.8 50 3.7 8270 52.1 50 3.7 7960 52.9 49
56 4.1 7781 52.7 49 3.9 8284 52.1 50 4.0 8331 52.2 50 4.0 8145 52.5 49
60 4.1 7508 53.0 49 4.1 8165 52.2 50 4.3 8046 52.6 50 4.0 7966 53.0 49
64 4.2 7514 53.4 49 4.2 8147 53.2 49 4.5 8223 52.7 50 4.2 8053 53.4 49
68 4.2 7276 53.2 49 4.3 7978 53.5 49 4.3 7815 53.2 50 4.2 7661 54.5 48
72 3.8 7581 54.1 48 4.0 7995 53.4 49 4.0 7871 52.8 50 3.9 7804 54.2 48
76 3.9 7449 53.6 48 4.0 7848 53.0 49 4.1 7879 52.2 50 4.0 7625 54.0 48
80 4.2 7388 52.5 48 4.0 7955 52.4 49 4.4 7749 51.8 49 4.1 7442 52.9 47
84 4.1 6973 53.0 45 4.2 7590 52.4 47 4.1 7420 53.0 46 4.1 7395 51.7 46
88 4.1 7034 51.7 44 3.9 7352 51.4 46 3.9 7275 52.3 45 3.9 6878 50.6 44
92 4.9 6547 50.9 41 4.3 7301 50.6 46 4.3 7100 51.4 45 4.2 6688 49.6 42
96 4.8 6479 50.7 39 4.3 7381 49.7 45 4.0 6817 50.3 44 4.1 6121 49.6 37
100 4.3 6284 48.6 39 4.0 7070 47.1 45 3.8 6651 48.1 41 3.9 5877 48.1 36
104 4.2 5882 46.6 38 4.2 6358 45.1 41 4.1 6451 46.5 41 4.0 5070 48.5 33
MEAN BODY WGT FOR WEEKS
1 TO 13 30.7 30.4 30.6 30.7
14 TO 52 50.2 49.4 49.7 50.2
> 52 51.8 51.2 51.5 51.7
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
=========================================================================================================
0 MG/L 500 MG/L 1000MG/L 2000MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 18.4 50 18.2 50 18.4 50 18.3 50
1 18.4 50 18.2 50 18.4 50 18.3 50
4 3.5 7743 22.3 50 3.4 8018 22.2 50 3.4 8117 22.4 50 3.9 8275 22.0 50
8 2.9 7515 27.3 50 3.1 7760 26.6 50 3.2 7547 27.1 48 3.5 7253 26.3 50
12 3.1 8290 32.0 50 3.2 7839 31.4 50 3.1 7383 31.6 48 3.5 7652 30.2 50
16 3.0 2936 36.5 50 3.1 2821 35.9 50 3.6 2902 36.0 48 3.1 7785 35.0 50
20 2.4 6563 42.3 50 2.4 7841 41.9 50 2.4 7174 42.3 48 2.5 7369 41.2 50
24 2.5 7912 46.9 50 2.3 7366 46.5 50 2.3 7006 46.8 48 2.4 7594 45.1 49
28 2.4 7879 49.9 50 2.7 7288 49.7 50 2.3 7445 50.3 48 2.9 6499 48.6 49
32 2.5 7837 52.5 50 2.4 8154 51.9 50 2.4 7716 52.7 48 2.4 8036 51.4 49
36 2.3 7916 54.4 50 2.5 7187 54.2 50 2.3 7190 54.3 48 2.5 7647 53.0 49
40 2.3 3420 57.8 49 2.3 3495 58.0 50 2.2 3432 57.4 48 2.4 3430 56.1 49
44 2.5 7371 58.4 49 2.7 7955 58.5 50 2.4 5946 57.2 48 2.8 7689 56.6 49
48 2.3 8142 60.2 49 2.4 8373 59.6 50 2.4 7490 58.6 48 2.7 7825 59.0 49
52 2.4 8147 61.0 49 2.4 7887 60.8 50 2.4 7935 59.9 48 2.5 7557 60.5 49
56 2.5 8193 61.2 49 2.5 8269 61.0 50 2.5 7962 60.1 48 2.6 8109 61.4 49
60 2.6 8084 62.2 49 2.6 8149 61.1 50 2.8 6633 60.9 48 2.8 7062 62.1 49
64 2.8 7724 62.8 48 2.7 7909 62.4 50 2.7 7748 62.7 48 3.2 7423 62.0 49
68 2.6 8001 63.4 48 2.7 7900 62.3 49 2.8 7886 62.9 48 2.5 7419 63.7 47
72 2.4 8053 64.2 48 2.8 7989 61.8 48 2.5 7740 63.1 47 2.7 7353 64.5 46
76 2.7 7796 65.0 47 2.8 7688 63.9 47 2.9 7392 64.3 45 2.8 7480 64.6 46
80 2.9 7788 66.5 47 2.8 7597 64.7 46 3.0 6934 65.0 44 2.9 7094 65.2 44
84 2.8 7595 65.7 46 2.8 6700 64.9 44 3.1 7098 64.3 43 2.8 7234 65.1 44
88 2.6 6809 65.9 41 3.0 6908 62.9 44 3.3 6635 61.7 42 2.7 7031 63.7 43
92 3.1 6591 64.9 39 3.8 7094 60.2 44 3.7 6262 62.3 39 3.0 6941 61.9 42
96 3.2 5381 64.3 38 3.5 6712 57.8 44 4.0 5826 60.1 37 3.2 6758 58.5 41
100 3.4 5770 63.3 37 4.2 6493 56.3 41 4.5 5863 57.3 36 3.4 5862 58.6 36
104 3.6 5759 61.0 36 3.7 5211 53.7 36 5.1 4909 55.0 31 4.1 5484 54.6 35
MEAN BODY WGT FOR WEEKS
1 TO 13 25.0 24.6 24.9 24.2
14 TO 52 52.0 51.7 51.6 50.7
> 52 63.9 61.0 61.5 62.0
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
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