National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5741

TDMS Study 96010-04 Pathology Tables

NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03
Route: DOSED WATER                                                                                                Time: 10:32:58

                                                          FINAL#1/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  7775-09-9

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     10           10           12            7                                     
    Moribund Sacrifice                                 3            5            6            8                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           34           31           35                                     
    Moribund Sacrifice                                              1                                                               
  Other                                                                          1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (48)         (49)                                   
      Hemorrhage                                       1 (2%)                                                                       
   Intestine Large, Cecum                             (44)         (47)         (47)         (47)                                   
      Edema                                            4 (9%)       6 (13%)      6 (13%)      6 (13%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Ulcer                                                                      1 (2%)                                             
   Intestine Small, Duodenum                          (46)         (47)         (47)         (50)                                   
      Ulcer                                                         1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                                                    2 (4%)                                             
   Intestine Small, Ileum                             (42)         (45)         (46)         (47)                                   
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Epithelium, Hyperplasia                                                    1 (2%)       1 (2%)                                
   Liver                                              (49)         (50)         (49)         (50)                                   
      Angiectasis                                      2 (4%)                    2 (4%)       1 (2%)                                
      Basophilic Focus                                 5 (10%)                   4 (8%)       1 (2%)                                
      Clear Cell Focus                                 3 (6%)                    1 (2%)                                             
      Eosinophilic Focus                               9 (18%)      9 (18%)     13 (27%)      7 (14%)                               
      Hematopoietic Cell Proliferation                 7 (14%)      4 (8%)       3 (6%)       8 (16%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Hepatodiaphragmatic Nodule                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                            4 (8%)       7 (14%)      3 (6%)       5 (10%)                               
      Infarct                                                       1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                7 (14%)      7 (14%)      8 (16%)      7 (14%)                               
      Mixed Cell Focus                                 7 (14%)      2 (4%)       3 (6%)       3 (6%)                                
      Necrosis, Focal                                  5 (10%)      1 (2%)       4 (8%)       1 (2%)                                
      Tension Lipidosis                                2 (4%)       3 (6%)                    1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis                          2 (4%)       2 (4%)       2 (4%)       2 (4%)                                
      Hepatocyte, Karyomegaly                                                                 3 (6%)                                
      Hepatocyte, Vacuolization Cytoplasmic            4 (8%)       3 (6%)       6 (12%)      4 (8%)                                
      Kupffer Cell, Hyperplasia                                     1 (2%)       1 (2%)       2 (4%)                                
      Kupffer Cell, Pigmentation                       3 (6%)       4 (8%)       4 (8%)       7 (14%)                               
   Mesentery                                          (30)         (32)         (27)         (24)                                   
      Angiectasis                                      1 (3%)                                 1 (4%)                                
      Hemorrhage                                       1 (3%)                                                                       
      Inflammation, Chronic                                                                   1 (4%)                                
      Fat, Necrosis                                   21 (70%)     24 (75%)     20 (74%)     16 (67%)                               
   Pancreas                                           (46)         (47)         (49)         (48)                                   
      Atrophy                                          2 (4%)       1 (2%)                    1 (2%)                                
      Cyst                                                          1 (2%)       1 (2%)                                             
      Acinus, Hyperplasia, Focal                                                              1 (2%)                                
   Salivary Glands                                    (48)         (47)         (49)         (50)                                   
      Hyperplasia, Lymphoid                           16 (33%)     21 (45%)     15 (31%)     18 (36%)                               
   Stomach, Forestomach                               (49)         (50)         (50)         (49)                                   
      Diverticulum                                     2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
      Edema                                                                      3 (6%)                                             
      Erosion                                                       1 (2%)       2 (4%)       2 (4%)                                
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic Active                                               2 (4%)       2 (4%)                                
      Ulcer                                            2 (4%)                    3 (6%)       3 (6%)                                
      Epithelium, Hyperplasia                          3 (6%)       4 (8%)       9 (18%)      6 (12%)                               
   Stomach, Glandular                                 (49)         (48)         (50)         (49)                                   
      Erosion                                                       1 (2%)       2 (4%)                                             
      Ulcer                                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (3)                       (1)                                    
      Aorta, Mineralization                                         1 (33%)                                                         
   Heart                                              (49)         (50)         (49)         (50)                                   
      Cardiomyopathy                                   1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                   1 (2%)                    1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (50)                                   
      Accessory Adrenal Cortical Nodule                4 (8%)       2 (4%)       7 (14%)      7 (14%)                               
      Hyperplasia, Focal                                                         1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Capsule, Hyperplasia                                                       1 (2%)       2 (4%)                                
      Zona Reticularis, Vacuolization Cytoplasmic                                1 (2%)       1 (2%)                                
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Hyperplasia                                      2 (4%)                    2 (4%)       1 (2%)                                
   Islets, Pancreatic                                 (46)         (47)         (49)         (49)                                   
      Hyperplasia                                      9 (20%)      6 (13%)      4 (8%)       3 (6%)                                
   Parathyroid Gland                                  (45)         (47)         (48)         (47)                                   
      Cyst                                             1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
   Pituitary Gland                                    (46)         (45)         (48)         (50)                                   
      Pars Distalis, Angiectasis                       1 (2%)       2 (4%)       2 (4%)                                             
      Pars Distalis, Cyst                                                                     1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                3 (7%)       3 (7%)       3 (6%)       1 (2%)                                
   Thyroid Gland                                      (48)         (50)         (49)         (50)                                   
      Degeneration, Cystic                            25 (52%)     28 (56%)     34 (69%)     32 (64%)                               
      Follicle, Cyst                                   1 (2%)       1 (2%)                    1 (2%)                                
      Follicular Cell, Cyst                                                                   2 (4%)                                
      Follicular Cell, Hypertrophy                     3 (6%)       2 (4%)       5 (10%)     14 (28%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (47)         (47)         (49)                                   
      Inflammation, Chronic                                         2 (4%)                    4 (8%)                                
   Ovary                                              (45)         (45)         (47)         (50)                                   
      Angiectasis                                      3 (7%)       2 (4%)       4 (9%)       3 (6%)                                
      Cyst                                             9 (20%)     14 (31%)     14 (30%)     13 (26%)                               
      Cyst, Hemorrhagic                                1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Thrombosis                                       3 (7%)       1 (2%)       1 (2%)                                             
      Bilateral, Cyst                                               1 (2%)                                                          
      Follicle, Hemorrhage                             1 (2%)       4 (9%)       4 (9%)       9 (18%)                               
      Granulosa Cell, Hyperplasia                                                3 (6%)       7 (14%)                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                    2 (4%)       1 (2%)                                
      Hyperplasia, Atypical                                         1 (2%)                                                          
      Hyperplasia, Cystic                             45 (90%)     45 (90%)     40 (80%)     41 (82%)                               
      Inflammation, Chronic                                                      2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Metaplasia, Squamous                                          2 (4%)       1 (2%)                                             
      Endometrium, Hyperplasia, Atypical                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     14 (28%)     28 (56%)     29 (58%)     31 (62%)                               
      Myelofibrosis                                    1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
   Lymph Node                                         (7)          (5)          (11)         (9)                                    
      Iliac, Hemorrhage                                                          1 (9%)                                             
      Iliac, Hyperplasia, Lymphoid                     1 (14%)                                1 (11%)                               
      Mediastinal, Hyperplasia, Lymphoid               1 (14%)      1 (20%)      2 (18%)                                            
      Mediastinal, Pigmentation                        1 (14%)                                                                      
      Pancreatic, Hemorrhage                                                                  1 (11%)                               
      Renal, Hemorrhage                                1 (14%)                                1 (11%)                               
   Lymph Node, Mandibular                             (46)         (46)         (49)         (49)                                   
      Atrophy                                                       1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                           12 (26%)      7 (15%)      7 (14%)     10 (20%)                               
      Pigmentation                                    18 (39%)     16 (35%)     18 (37%)     15 (31%)                               
   Lymph Node, Mesenteric                             (47)         (49)         (49)         (49)                                   
      Atrophy                                          1 (2%)       1 (2%)                    2 (4%)                                
      Ectasia                                          2 (4%)                                 1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Hemorrhage                                       4 (9%)       2 (4%)                    1 (2%)                                
      Hyperplasia, Lymphoid                           10 (21%)      8 (16%)     11 (22%)      6 (12%)                               
      Pigmentation                                     1 (2%)       2 (4%)                                                          
   Spleen                                             (49)         (48)         (49)         (50)                                   
      Accessory Spleen                                                                        1 (2%)                                
      Hematopoietic Cell Proliferation                39 (80%)     39 (81%)     35 (71%)     39 (78%)                               
      Hyperplasia, Lymphoid                           11 (22%)     10 (21%)      5 (10%)      9 (18%)                               
      Pigmentation                                    28 (57%)     30 (63%)     28 (57%)     27 (54%)                               
      Lymphoid Follicle, Atrophy                       1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
   Thymus                                             (48)         (44)         (48)         (48)                                   
      Atrophy                                          5 (10%)      7 (16%)      5 (10%)      9 (19%)                               
      Cyst                                             3 (6%)                    1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            5 (10%)      3 (7%)       4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Hyperplasia                                      5 (10%)     11 (22%)      8 (16%)     10 (20%)                               
   Skin                                               (48)         (50)         (50)         (50)                                   
      Edema                                                         1 (2%)                    1 (2%)                                
      Epidermis, Hyperplasia                           1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Edema                                                 1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Callus                                           1 (2%)                                                                       
      Fracture                                                                   1 (2%)       1 (2%)                                
      Hyperostosis                                     1 (2%)       1 (2%)       4 (8%)       3 (6%)                                
      Cranium, Osteopetrosis                                                     1 (2%)                                             
      Femur, Osteopetrosis                                          1 (2%)       1 (2%)                                             
   Skeletal Muscle                                                 (2)          (4)          (6)                                    
      Angiectasis                                                                             1 (17%)                               
      Atrophy                                                                                 1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Necrosis                                                                   1 (2%)       1 (2%)                                
   Peripheral Nerve                                                             (2)          (2)                                    
      Atrophy                                                                    1 (50%)      2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Edema                                            5 (10%)      8 (16%)      3 (6%)       5 (10%)                               
      Foreign Body                                     2 (4%)                                                                       
      Hemorrhage                                       5 (10%)      8 (16%)      6 (12%)      4 (8%)                                
      Hyperplasia, Lymphoid                           10 (20%)      8 (16%)      3 (6%)       9 (18%)                               
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)       1 (2%)       3 (6%)       5 (10%)                               
      Metaplasia, Osseous                                           1 (2%)       2 (4%)                                             
      Thrombosis                                       1 (2%)       4 (8%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (48)         (50)         (50)                                   
      Inflammation, Chronic                            3 (6%)       3 (6%)                                                          
      Cornea, Hyperplasia                              2 (4%)       1 (2%)                                                          
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Cyst                                                                                    1 (2%)                                
      Hyperplasia, Focal                               1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Hydronephrosis                                                             1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            8 (16%)      9 (18%)      6 (12%)      8 (16%)                               
      Infarct                                          3 (6%)       2 (4%)       4 (8%)       5 (10%)                               
      Metaplasia, Osseous                                           1 (2%)       3 (6%)       2 (4%)                                
      Nephropathy                                     14 (28%)     11 (22%)     14 (29%)     12 (24%)                               
      Renal Tubule, Accumulation, Hyaline Droplet      2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Renal Tubule, Dilatation                         1 (2%)                                 1 (2%)                                
      Renal Tubule, Necrosis                           1 (2%)                                 1 (2%)                                
      Renal Tubule, Pigmentation                       3 (6%)       1 (2%)                    1 (2%)                                
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                            4 (8%)      12 (24%)      4 (8%)       5 (10%)                               
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            4            5            7                                     
    Moribund Sacrifice                                 5            5            4           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           41           41           33                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (49)         (49)         (48)                                   
      Edema                                            1 (2%)       3 (6%)       4 (8%)       2 (4%)                                
      Inflammation, Chronic                                         1 (2%)                    1 (2%)                                
   Intestine Small, Duodenum                          (48)         (50)         (49)         (49)                                   
      Ulcer                                                         1 (2%)       1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)       1 (2%)                                
   Intestine Small, Jejunum                           (47)         (49)         (50)         (50)                                   
      Epithelium, Hyperplasia                                                                 2 (4%)                                
   Intestine Small, Ileum                             (47)         (49)         (49)         (49)                                   
      Cyst                                                          1 (2%)                                                          
   Liver                                              (48)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       2 (4%)                                                          
      Basophilic Focus                                              2 (4%)       3 (6%)       4 (8%)                                
      Clear Cell Focus                                12 (25%)     19 (38%)     19 (38%)     13 (26%)                               
      Cyst                                                                       1 (2%)       1 (2%)                                
      Eosinophilic Focus                              11 (23%)     10 (20%)      5 (10%)     11 (22%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                 4 (8%)                                
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Infiltration Cellular, Mixed Cell                2 (4%)       1 (2%)       1 (2%)                                             
      Mixed Cell Focus                                 2 (4%)       9 (18%)      8 (16%)      7 (14%)                               
      Necrosis, Focal                                  4 (8%)       6 (12%)      7 (14%)      6 (12%)                               
      Regeneration, Focal                                                        1 (2%)                                             
      Tension Lipidosis                                1 (2%)                    1 (2%)                                             
      Bile Duct, Hyperplasia                                                                  2 (4%)                                
      Centrilobular, Necrosis                          1 (2%)                                 2 (4%)                                
      Hepatocyte, Karyomegaly                                                    1 (2%)       1 (2%)                                
      Hepatocyte, Vacuolization Cytoplasmic            2 (4%)                                 3 (6%)                                
      Kupffer Cell, Pigmentation                       2 (4%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (9)          (10)         (10)         (8)                                    
      Infarct                                                                    1 (10%)                                            
      Inflammation, Chronic                            1 (11%)                                2 (25%)                               
      Fat, Necrosis                                    3 (33%)      8 (80%)      6 (60%)      5 (63%)                               
   Pancreas                                           (48)         (50)         (50)         (50)                                   
      Cyst                                                                                    2 (4%)                                
      Acinus, Cytoplasmic Alteration                                             1 (2%)       1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 (2%)       2 (4%)                                
      Hyperplasia, Lymphoid                            7 (14%)      3 (6%)       6 (12%)      4 (8%)                                
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Cyst                                             2 (4%)                                                                       
      Diverticulum                                     1 (2%)       1 (2%)                    2 (4%)                                
      Erosion                                                       1 (2%)                                                          
      Inflammation, Chronic Active                     2 (4%)       2 (4%)       4 (8%)       2 (4%)                                
      Ulcer                                            1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Epithelium, Hyperplasia                          3 (6%)       7 (14%)      2 (4%)       4 (8%)                                
   Stomach, Glandular                                 (48)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)       2 (4%)       1 (2%)                                             
      Ulcer                                                                                   1 (2%)                                
   Tooth                                              (2)          (4)          (1)          (3)                                    
      Malformation                                     2 (100%)     4 (100%)                  2 (67%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                                          2 (4%)                                
      Inflammation, Chronic                            2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Mineralization                                   1 (2%)                                 2 (4%)                                
      Thrombosis                                                                 1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                6 (12%)      5 (10%)      3 (6%)       5 (10%)                               
      Degeneration, Fatty                              1 (2%)       1 (2%)                    2 (4%)                                
      Hyperplasia, Focal                               4 (8%)       6 (12%)      7 (14%)      9 (18%)                               
      Hypertrophy                                      1 (2%)                                                                       
      Hypertrophy, Focal                               9 (18%)     16 (32%)     11 (22%)     11 (22%)                               
      Capsule, Hyperplasia                             5 (10%)      3 (6%)       1 (2%)       8 (16%)                               
   Adrenal Medulla                                    (49)         (48)         (49)         (49)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 (2%)       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (48)         (50)         (50)         (50)                                   
      Hyperplasia                                     31 (65%)     25 (50%)     28 (56%)     23 (46%)                               
   Parathyroid Gland                                  (46)         (48)         (47)         (49)                                   
      Cyst                                                          1 (2%)       2 (4%)       1 (2%)                                
   Pituitary Gland                                    (47)         (47)         (45)         (49)                                   
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       2 (4%)       5 (10%)                               
      Pars Intermedia, Cyst                            1 (2%)                                                                       
   Thyroid Gland                                      (48)         (50)         (48)         (50)                                   
      Degeneration, Cystic                            13 (27%)     17 (34%)     14 (29%)     15 (30%)                               
      Follicular Cell, Hypertrophy                     2 (4%)                    1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Atypia Cellular                                  1 (2%)       6 (12%)      4 (8%)       3 (6%)                                
      Granuloma Sperm                                               1 (2%)                    1 (2%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)       1 (2%)                                
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                            22 (44%)     26 (52%)     15 (30%)     29 (58%)                               
      Inflammation, Chronic                           28 (56%)     27 (54%)     18 (36%)     21 (42%)                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 (2%)       4 (8%)       3 (6%)       5 (10%)                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Degeneration                                                  1 (2%)                    2 (4%)                                
      Dilatation                                                                 1 (2%)                                             
      Inflammation, Chronic                            3 (6%)                    1 (2%)                                             
   Testes                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                 1 (2%)                                
      Atrophy                                                       1 (2%)       1 (2%)       1 (2%)                                
      Necrosis                                                                                1 (2%)                                
      Germinal Epithelium, Atrophy                     1 (2%)       5 (10%)      3 (6%)       4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                     21 (43%)     12 (24%)     13 (26%)     15 (30%)                               
   Lymph Node                                         (3)                       (1)          (3)                                    
      Mediastinal, Hemorrhage                                                                 1 (33%)                               
   Lymph Node, Mandibular                             (49)         (48)         (45)         (49)                                   
      Atrophy                                          1 (2%)                                 1 (2%)                                
      Hyperplasia, Lymphoid                           14 (29%)     14 (29%)     16 (36%)     16 (33%)                               
      Pigmentation                                     7 (14%)     10 (21%)      9 (20%)      9 (18%)                               
   Lymph Node, Mesenteric                             (47)         (50)         (50)         (50)                                   
      Atrophy                                          2 (4%)       1 (2%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                 2 (4%)                    4 (8%)       1 (2%)                                
      Hemorrhage                                       4 (9%)       6 (12%)      2 (4%)       4 (8%)                                
      Hyperplasia, Lymphoid                           11 (23%)      6 (12%)      6 (12%)      9 (18%)                               
   Spleen                                             (48)         (50)         (50)         (50)                                   
      Depletion Lymphoid                                                                      1 (2%)                                
      Hematopoietic Cell Proliferation                21 (44%)     17 (34%)     18 (36%)     21 (42%)                               
      Hyperplasia, Lymphoid                            8 (17%)      9 (18%)     10 (20%)      8 (16%)                               
      Pigmentation                                                  3 (6%)       1 (2%)       1 (2%)                                
      Lymphoid Follicle, Atrophy                       1 (2%)                    1 (2%)       3 (6%)                                
   Thymus                                             (43)         (43)         (40)         (44)                                   
      Atrophy                                         11 (26%)     13 (30%)      4 (10%)     13 (30%)                               
      Cyst                                             1 (2%)       3 (7%)       4 (10%)      4 (9%)                                
      Hyperplasia, Lymphoid                            2 (5%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Edema                                                                                   3 (6%)                                
      Inflammation, Chronic                                                      1 (2%)       1 (2%)                                
      Ulcer                                            2 (4%)                                                                       
      Epidermis, Hyperplasia                           1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fracture                                         1 (2%)       1 (2%)                    2 (4%)                                
      Hyperostosis                                     1 (2%)       1 (2%)                                                          
   Skeletal Muscle                                    (3)          (1)          (3)          (2)                                    
      Atrophy                                                       1 (100%)                                                        
      Infiltration Cellular, Lipocyte                  1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                                (1)          (2)          (1)                                    
      Atrophy                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Edema                                            6 (12%)     11 (22%)      7 (14%)      8 (16%)                               
      Foreign Body                                     1 (2%)                                 1 (2%)                                
      Hemorrhage                                       5 (10%)      3 (6%)       4 (8%)       5 (10%)                               
      Hyperplasia, Lymphoid                            4 (8%)       5 (10%)      7 (14%)      6 (12%)                               
      Infiltration Cellular, Histiocyte                8 (16%)      5 (10%)      9 (18%)     10 (20%)                               
      Metaplasia, Osseous                                           2 (4%)                                                          
      Alveolar Epithelium, Hyperplasia                 2 (4%)       3 (6%)       1 (2%)       5 (10%)                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)       1 (2%)                    2 (4%)                                
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)       5 (10%)                               
      Respiratory Epithelium, Hyperplasia              1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (50)         (50)         (50)                                   
      Cataract                                                      1 (2%)                                                          
      Inflammation, Chronic                                                      3 (6%)                                             
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia, Focal                               1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)       3 (6%)       3 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Cyst                                            14 (29%)     10 (20%)      9 (18%)     10 (20%)                               
      Hydronephrosis                                   1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Hyperplasia, Lymphoid                            8 (16%)      6 (12%)      4 (8%)      11 (22%)                               
      Infarct                                          5 (10%)      1 (2%)       4 (8%)       5 (10%)                               
      Inflammation, Chronic                                         1 (2%)                    1 (2%)                                
      Metaplasia, Osseous                              7 (14%)      5 (10%)      3 (6%)       4 (8%)                                
      Nephropathy                                     37 (76%)     42 (84%)     43 (86%)     36 (72%)                               
      Renal Tubule, Accumulation, Hyaline Droplet                   1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03    
Route: DOSED WATER                                                                                                Time: 10:32:58    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Dilatation                         1 (2%)       2 (4%)                    3 (6%)                                
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)                    1 (2%)                                
      Renal Tubule, Necrosis                           1 (2%)                                 2 (4%)                                
      Renal Tubule, Pigmentation                                    2 (4%)       1 (2%)       1 (2%)                                
   Urethra                                                                      (1)                                                 
      Angiectasis                                                                1 (100%)                                           
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)                                 1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                                                   1 (2%)                                
      Transitional Epithelium, Hyperplasia                          2 (4%)                    1 (2%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.