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TDMS Study 96010-04 Pathology Tables

NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03
Route: DOSED WATER                                                                                                Time: 10:40:52

                                                          FINAL#1/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  7775-09-9

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     10           10           12            7                                     
    Moribund Sacrifice                                 3            5            6            8                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           34           31           35                                     
    Moribund Sacrifice                                              1                                                               
  Other                                                                          1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (50)         (50)         (50)                                   
   Gallbladder                                        (40)         (44)         (44)         (48)                                   
   Intestine Large, Cecum                             (44)         (47)         (47)         (47)                                   
      Hemangioma                                                                 1 (2%)                                             
   Intestine Small, Duodenum                          (46)         (47)         (47)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Polyp Adenomatous                                                                       1 (2%)                                
   Intestine Small, Jejunum                           (45)         (47)         (47)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Small, Ileum                             (42)         (45)         (46)         (47)                                   
   Liver                                              (49)         (50)         (49)         (50)                                   
      Hemangioma                                       2 (4%)                                                                       
      Hemangiosarcoma                                  1 (2%)       2 (4%)                                                          
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)                                                          
      Hepatoblastoma                                   1 (2%)                                                                       
      Hepatocellular Carcinoma                         2 (4%)       6 (12%)     11 (22%)      6 (12%)                               
      Hepatocellular Carcinoma, Multiple               1 (2%)       7 (14%)      4 (8%)       3 (6%)                                
      Hepatocellular Adenoma                          15 (31%)      9 (18%)     14 (29%)      8 (16%)                               
      Hepatocellular Adenoma, Multiple                15 (31%)     10 (20%)     12 (24%)     15 (30%)                               
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
   Mesentery                                          (30)         (32)         (27)         (24)                                   
      Fibrosarcoma                                                               1 (4%)                                             
      Fibrous Histiocytoma                             1 (3%)                                                                       
      Hemangiosarcoma                                                                         1 (4%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (4%)                                             
      Histiocytic Sarcoma                                                        1 (4%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Sarcoma, Metastatic, Skin                                                               1 (4%)                                
      Schwannoma Malignant, Metastatic, Skin           1 (3%)                                                                       
   Oral Mucosa                                        (2)                                    (1)                                    
      Squamous Cell Carcinoma                          1 (50%)                                                                      
      Squamous Cell Papilloma                                                                 1 (100%)                              
   Pancreas                                           (46)         (47)         (49)         (48)                                   
      Fibrosarcoma, Metastatic, Mesentery                                        1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
      Acinus, Sarcoma                                                            1 (2%)                                             
   Salivary Glands                                    (48)         (47)         (49)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Forestomach                               (49)         (50)         (50)         (49)                                   
      Squamous Cell Carcinoma                                       1 (2%)       1 (2%)                                             
      Squamous Cell Papilloma                                                    1 (2%)       1 (2%)                                
      Squamous Cell Papilloma, Multiple                                          1 (2%)                                             
   Stomach, Glandular                                 (49)         (48)         (50)         (49)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
   Tongue                                                                       (2)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (49)         (50)                                   
      Hemangiosarcoma, Metastatic, Spleen                           1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Subcapsular, Adenoma                             1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Pheochromocytoma Malignant                       2 (4%)                                                                       
      Pheochromocytoma Complex                                                                1 (2%)                                
      Pheochromocytoma Benign                          1 (2%)                                 1 (2%)                                
   Islets, Pancreatic                                 (46)         (47)         (49)         (49)                                   
      Adenoma                                                       2 (4%)       2 (4%)       3 (6%)                                
      Carcinoma                                                                               1 (2%)                                
   Pituitary Gland                                    (46)         (45)         (48)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Pars Distalis, Adenoma                           3 (7%)       2 (4%)       4 (8%)       4 (8%)                                
   Thyroid Gland                                      (48)         (50)         (49)         (50)                                   
      Follicular Cell, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (47)         (47)         (49)                                   
   Ovary                                              (45)         (45)         (47)         (50)                                   
      Choriocarcinoma                                                            2 (4%)                                             
      Cystadenoma                                      1 (2%)       4 (9%)       1 (2%)       1 (2%)                                
      Granulosa Cell Tumor Malignant                                                          1 (2%)                                
      Granulosa Cell Tumor Benign                      1 (2%)       1 (2%)       1 (2%)       5 (10%)                               
      Histiocytic Sarcoma                                                        2 (4%)       1 (2%)                                
      Luteoma                                          3 (7%)                    1 (2%)                                             
      Yolk Sac Carcinoma                                                                      1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                                                        2 (4%)       1 (2%)                                
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                    1 (2%)                                 3 (6%)                                
      Yolk Sac Carcinoma, Metastatic, Ovary                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                  1 (2%)       1 (2%)       2 (4%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (7)          (5)          (11)         (9)                                    
      Histiocytic Sarcoma                                                        1 (9%)                                             
      Liposarcoma, Metastatic, Skin                                 1 (20%)                                                         
      Iliac, Histiocytic Sarcoma                                                 2 (18%)                                            
      Iliac, Liposarcoma, Metastatic, Skin                          1 (20%)                                                         
      Mediastinal, Sarcoma, Metastatic, Pancreas                                 1 (9%)                                             
      Pancreatic, Histiocytic Sarcoma                                            1 (9%)                                             
      Renal, Histiocytic Sarcoma                                                 1 (9%)       1 (11%)                               
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (46)         (46)         (49)         (49)                                   
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                                              1 (2%)                                
   Lymph Node, Mesenteric                             (47)         (49)         (49)         (49)                                   
      Histiocytic Sarcoma                                           1 (2%)       2 (4%)                                             
      Histiocytic Sarcoma, Metastatic, Mesentery                                 1 (2%)                                             
      Yolk Sac Carcinoma, Metastatic, Ovary                                                   1 (2%)                                
   Spleen                                             (49)         (48)         (49)         (50)                                   
      Hemangiosarcoma                                  2 (4%)       1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Thymus                                             (48)         (44)         (48)         (48)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Skin                                               (48)         (50)         (50)         (50)                                   
      Hemangioma                                                    1 (2%)                                                          
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                    2 (4%)                                
      Subcutaneous Tissue, Hemangioma                                                         1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Liposarcoma                              1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
      Subcutaneous Tissue, Schwannoma Malignant        3 (6%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                                  1 (2%)       1 (2%)       2 (4%)                                
      Sarcoma                                                                    1 (2%)                                             
   Skeletal Muscle                                                 (2)          (4)          (6)                                    
      Histiocytic Sarcoma, Metastatic, Mesentery                                 1 (25%)                                            
      Rhabdomyosarcoma                                              1 (50%)      1 (25%)      2 (33%)                               
      Sarcoma, Metastatic, Pancreas                                              1 (25%)                                            
      Sarcoma, Metastatic, Skin                                                               1 (17%)                               
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - cont                                                                                                       
      Yolk Sac Carcinoma, Metastatic, Ovary                                                   1 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     3 (6%)       1 (2%)                    3 (6%)                                
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       3 (6%)       5 (10%)      2 (4%)                                
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Liposarcoma, Metastatic, Skin                                 1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Carcinoma                                        1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (48)         (50)         (50)                                   
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Adenoma                                         11 (22%)      9 (18%)      5 (10%)      6 (12%)                               
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)       4 (8%)       2 (4%)                                
      Leukemia Granulocytic                                                      1 (2%)                                             
      Lymphoma Malignant                              23 (46%)     19 (38%)     28 (56%)     27 (54%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          45          46          47                                       
     Total Primary Neoplasms                           99          87         108         105                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38          27          33          31                                       
     Total Benign Neoplasms                            58          40          44          53                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          38          41          41                                       
     Total Malignant Neoplasms                         41          47          64          52                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           5          10           5                                       
     Total Metastatic Neoplasm                          2           8          20          11                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            4            5            7                                     
    Moribund Sacrifice                                 5            5            4           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           41           41           33                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Intestine Large, Cecum                             (47)         (49)         (49)         (48)                                   
      Carcinoma                                                                               1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Intestine Small, Duodenum                          (48)         (50)         (49)         (49)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                                               1 (2%)                                
      Carcinoma, Metastatic, Islets, Pancreatic                                               1 (2%)                                
      Polyp Adenomatous                                                          2 (4%)                                             
   Intestine Small, Jejunum                           (47)         (49)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Carcinoma                                        2 (4%)       2 (4%)                    2 (4%)                                
   Liver                                              (48)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                                               1 (2%)                                
      Cholangiocarcinoma                               1 (2%)                    1 (2%)                                             
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)       2 (4%)       1 (2%)       2 (4%)                                
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Hepatoblastoma                                   5 (10%)      3 (6%)       1 (2%)       3 (6%)                                
      Hepatoblastoma, Multiple                         1 (2%)                                                                       
      Hepatocellular Carcinoma                        14 (29%)     13 (26%)     14 (28%)     12 (24%)                               
      Hepatocellular Carcinoma, Multiple               6 (13%)      1 (2%)       5 (10%)      1 (2%)                                
      Hepatocellular Adenoma                          16 (33%)     15 (30%)     13 (26%)     14 (28%)                               
      Hepatocellular Adenoma, Multiple                14 (29%)     17 (34%)     23 (46%)     16 (32%)                               
      Histiocytic Sarcoma                              1 (2%)                    2 (4%)       2 (4%)                                
      Ito Cell Tumor Malignant                                      1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Mesentery            1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Mesentery                                          (9)          (10)         (10)         (8)                                    
      Cholangiocarcinoma, Metastatic, Liver            1 (11%)                                                                      
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (10%)      1 (13%)                               
      Histiocytic Sarcoma                                                                     2 (25%)                               
      Histiocytic Sarcoma, Metastatic, Liver           1 (11%)                                                                      
      Ito Cell Tumor Malignant, Metastatic, Liver                   1 (10%)                                                         
      Leiomyosarcoma                                   1 (11%)                                                                      
      Liposarcoma                                                                1 (10%)                                            
   Pancreas                                           (48)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Leiomyosarcoma, Metastatic, Mesentery            1 (2%)                                                                       
      Squamous Cell Papilloma                                                    2 (4%)       2 (4%)                                
   Stomach, Glandular                                 (48)         (50)         (50)         (50)                                   
      Adenoma                                                       2 (4%)                                                          
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Mesentery            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Bilateral, Subcapsular, Adenoma                  1 (2%)                                                                       
      Subcapsular, Adenoma                             1 (2%)       3 (6%)       4 (8%)       2 (4%)                                
   Islets, Pancreatic                                 (48)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Carcinoma                                                                               1 (2%)                                
   Pituitary Gland                                    (47)         (47)         (45)         (49)                                   
      Pars Distalis, Adenoma                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Cholangiocarcinoma, Metastatic, Liver                                      1 (2%)                                             
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Prostate                                           (50)         (50)         (50)         (50)                                   
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Interstitial Cell, Adenoma                                                              2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node                                         (3)                       (1)          (3)                                    
      Mediastinal, Carcinoma, Metastatic,                                                                                           
          Harderian Gland                                                                     1 (33%)                               
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                      1 (100%)     1 (33%)                               
      Mediastinal, Histiocytic Sarcoma, Metastatic,                                                                                 
           Liver                                       1 (33%)                                                                      
      Mediastinal, Leiomyosarcoma, Metastatic,                                                                                      
           Mesentery                                   1 (33%)                                                                      
      Pancreatic, Hepatocellular Carcinoma,                                                                                         
          Metastatic, Liver                                                      1 (100%)                                           
      Pancreatic, Histiocytic Sarcoma, Metastatic,                                                                                  
           Liver                                       1 (33%)                                                                      
      Renal, Hepatocellular Carcinoma, Metastatic,                                                                                  
           Liver                                                                 1 (100%)                                           
      Renal, Histiocytic Sarcoma, Metastatic, Liver    1 (33%)                                                                      
      Renal, Leiomyosarcoma, Metastatic, Mesentery     1 (33%)                                                                      
   Lymph Node, Mandibular                             (49)         (48)         (45)         (49)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Lymph Node, Mesenteric                             (47)         (50)         (50)         (50)                                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Leiomyosarcoma, Metastatic, Mesentery            1 (2%)                                                                       
   Spleen                                             (48)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Mesentery            1 (2%)                                                                       
   Thymus                                             (43)         (43)         (40)         (44)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (3%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (3%)                                             
      Leiomyosarcoma, Metastatic, Mesentery            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Subcutaneous Tissue, Fibrous Histiocytoma                                  1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
   Skeletal Muscle                                    (3)          (1)          (3)          (2)                                    
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  2 (67%)                                            
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (50%)                               
      Histiocytic Sarcoma, Metastatic, Liver           1 (33%)                                                                      
      Leiomyosarcoma, Metastatic, Mesentery            1 (33%)                                                                      
      Rhabdomyosarcoma                                                                        1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     6 (12%)      4 (8%)       7 (14%)      6 (12%)                               
      Alveolar/Bronchiolar Carcinoma                   4 (8%)       5 (10%)      6 (12%)      4 (8%)                                
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
      Hemangiosarcoma                                                                         1 (2%)                                
      Hepatoblastoma, Metastatic, Liver                1 (2%)       2 (4%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      9 (18%)      2 (4%)       4 (8%)       6 (12%)                               
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Liver           1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Mesentery            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Adenoma                                          6 (12%)      4 (8%)       4 (8%)       6 (12%)                               
      Carcinoma                                                                  1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)                                             
      Renal Tubule, Adenoma                                         1 (2%)                                                          
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                    2 (4%)       3 (6%)                                
      Lymphoma Malignant                               3 (6%)       1 (2%)                    3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96010-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                          WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                      Date: 03/26/03  
Route: DOSED WATER                                                                                                Time: 10:40:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          45          47          45                                       
     Total Primary Neoplasms                           86          76          95          87                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          38          37          34                                       
     Total Benign Neoplasms                            47          48          59          51                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          22          30          27                                       
     Total Malignant Neoplasms                         39          28          36          36                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             12           5           9           8                                       
     Total Metastatic Neoplasm                         38           5          20          14                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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