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TDMS Study 96010-04 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:44:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
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                                                            FINAL#1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Southern Research Inst                  WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                   DATE: 03/26/03       
EXPERIMENT: 96010 TEST: 04                                                                                     TIME: 10:44:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85420                              ROUTE: DOSED WATER                                             NTP C#: 96010A       
PATHOLOGIST: HEATH, JAMES E.                                                                                   CAS: 7775-09-9       
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF     WATER DISINFECTION BYPRODUCTS (SODIUM                                                                        
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Cortex                         Hyperplasia Focal                                                                            
Adrenal Cortex: Capsule                Hyperplasia                                                                                  
Bone Marrow                            Hyperplasia                                                                                  
Epididymis                             Atypia Cellular                                                                              
Heart                                  Cardiomyopathy                                                                               
Intestine Small, Jejunum: Epithelium   Hyperplasia                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Hematopoietic Cell Proliferation                                                             
                                       Mixed Cell Focus                                                                             
Liver: Bile Duct                       Hyperplasia                                                                                  
Nose                                   Inflammation Chronic                                                                         
Pancreas                               Cyst                                                                                         
Pituitary Gland: Pars Distalis         Cyst                                                                                         
Preputial Gland                        Cyst                                                                                         
                                       Inflammation Chronic                                                                         
Seminal Vesicle                        Inflammation Chronic                                                                         
Skin                                   Edema                                                                                        
                                       Ulcer                                                                                        
Stomach, Forestomach                   Cyst                                                                                         
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Bone Marrow                            Hyperplasia                                                                                  
Clitoral Gland                         Inflammation Chronic                                                                         
Eye                                    Inflammation Chronic                                                                         
Islets, Pancreatic                     Hyperplasia                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Clear Cell Focus                                                                             
Liver: Hepatocyte                      Karyomegaly                                                                                  
Lung                                   Foreign Body                                                                                 
                                       Hyperplasia Lymphoid                                                                         
                                       Infiltration Cellular Histiocyte                                                             
Lymph Node, Mesenteric                 Hemorrhage                                                                                   
Ovary                                  Thrombosis                                                                                   
Ovary: Follicle                        Hemorrhage                                                                                   
Ovary: Granulosa Cell                  Hyperplasia                                                                                  
Thyroid Gland                          Degeneration Cystic                                                                          
Thyroid Gland: Follicular Cell         Cyst                                                                                         
                                       Hypertrophy                                                                                  
Urinary Bladder                        Hyperplasia Lymphoid                                                                         
Uterus                                 Hyperplasia Cystic                                                                           
===============================================================                                                                     
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                 
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   5/50 (10%)   3/50 (6%)    5/50 (10%)  |4/50 (8%)    2/49 (4%)    7/49 (14%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     6/45.15      5/47.28      3/46.95      5/44.19     |4/44.38      2/44.88      7/42.43      7/44.58      | 
|POLY-3 PERCENT (g) |     13.3%        10.6%        6.4%         11.3%       |9.0%         4.5%         16.5%        15.7%        | 
|TERMINAL (d)       |     5/38 (13%)   5/41 (12%)   1/41 (2%)    4/33 (12%)  |1/36 (3%)    1/34 (3%)    5/31 (16%)   5/35 (14%)   | 
|FIRST INCIDENCE    |     561          729 (T)      667          616         |591          568          618          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.508N     P=0.451N     P=0.211N     P=0.581N    |P=0.103      P=0.340N     P=0.219      P=0.263      | 
|POLY 3             |     P=0.436N     P=0.468N     P=0.223N     P=0.515N    |P=0.097      P=0.332N     P=0.234      P=0.263      | 
|POLY 1.5           |     P=0.429N     P=0.480N     P=0.230N     P=0.508N    |P=0.100      P=0.337N     P=0.234      P=0.264      | 
|POLY 6             |     P=0.445N     P=0.453N     P=0.215N     P=0.525N    |P=0.094      P=0.327N     P=0.232      P=0.261      | 
|LOGISTIC REGRESSION|     P=0.429N     P=0.468N     P=0.248N     P=0.507N    |P=0.107      P=0.371N     P=0.240      P=0.274      | 
|COCH-ARM / FISHERS |     P=0.419N     P=0.500N     P=0.243N     P=0.500N    |P=0.103      P=0.349N     P=0.251      P=0.262      | 
|ORDER RESTRICTED   |     P=0.391N     (e)          (e)          (e)         |P=0.122      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Degeneration Fatty                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.60      1/47.28      0/46.48      2/43.80     |0/43.63      0/44.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    1/41 (2%)    0/41 (0%)    2/33 (6%)   |0/36 (0%)    0/34 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318      P=0.745N     P=0.485N     P=0.451     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.360      P=0.747N     P=0.492N     P=0.494     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.363      P=0.752N     P=0.494N     P=0.497     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.355      P=0.741N     P=0.489N     P=0.489     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.318      P=0.745N     (e)          P=0.451     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.366      P=0.753N     P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.258      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    6/50 (12%)   7/50 (14%)   9/50 (18%)  |0/50 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.72      6/47.28      7/46.48      9/43.84     |0/43.63      0/44.35      1/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     8.9%         12.7%        15.1%        20.5%       |0.0%         0.0%         2.4%         0.0%         | 
|TERMINAL (d)       |     3/38 (8%)    6/41 (15%)   7/41 (17%)   8/33 (24%)  |0/36 (0%)    0/34 (0%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     699          729 (T)      729 (T)      719         |---          ---          729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.042 *    P=0.421      P=0.305      P=0.075     |P=0.687      (e)          P=0.470      (e)          | 
|POLY 3             |     P=0.076      P=0.405      P=0.283      P=0.106     |P=0.689      (e)          P=0.492      (e)          | 
|POLY 1.5           |     P=0.081      P=0.392      P=0.277      P=0.111     |P=0.690      (e)          P=0.491      (e)          | 
|POLY 6             |     P=0.068      P=0.421      P=0.289      P=0.099     |P=0.690      (e)          P=0.493      (e)          | 
|LOGISTIC REGRESSION|     P=0.050      P=0.440      P=0.299      P=0.090     |(e)          (e)          P=0.470      (e)          | 
|COCH-ARM / FISHERS |     P=0.088      P=0.370      P=0.262      P=0.117     |P=0.694      (e)          P=0.495      (e)          | 
|ORDER RESTRICTED   |     P=0.094      (e)          (e)          (e)         |P=0.374      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   16/50 (32%)  11/50 (22%)  11/50 (22%) |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     9/44.60      16/47.41     11/46.48     11/44.40    |0/43.63      0/44.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     20.2%        33.8%        23.7%        24.8%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     9/38 (24%)   13/41 (32%)  11/41 (27%)  10/33 (30%) |0/36 (0%)    0/34 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      713          729 (T)      535         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.380      P=0.127      P=0.475      P=0.273     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.540      P=0.108      P=0.441      P=0.395     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.542N     P=0.097      P=0.428      P=0.399     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.524      P=0.124      P=0.454      P=0.387     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.468      P=0.143      P=0.475      P=0.364     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.534N     P=0.083      P=0.402      P=0.402     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.345      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Capsule                                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    1/50 (2%)    8/50 (16%)  |0/50 (0%)    0/49 (0%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     5/44.60      3/47.34      1/46.48      8/44.86     |0/43.63      0/44.35      1/42.00      2/44.56      | 
|POLY-3 PERCENT (g) |     11.2%        6.3%         2.2%         17.8%       |0.0%         0.0%         2.4%         4.5%         | 
|TERMINAL (d)       |     5/38 (13%)   1/41 (2%)    1/41 (2%)    6/33 (18%)  |0/36 (0%)    0/34 (0%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      721          729 (T)      535         |---          ---          729 (T)      447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.094      P=0.314N     P=0.086N     P=0.206     |P=0.073      (e)          P=0.470      P=0.247      | 
|POLY 3             |     P=0.134      P=0.324N     P=0.092N     P=0.278     |P=0.072      (e)          P=0.492      P=0.242      | 
|POLY 1.5           |     P=0.136      P=0.337N     P=0.095N     P=0.278     |P=0.071      (e)          P=0.491      P=0.239      | 
|POLY 6             |     P=0.129      P=0.309N     P=0.089N     P=0.276     |P=0.073      (e)          P=0.493      P=0.246      | 
|LOGISTIC REGRESSION|     P=0.133      P=0.292N     P=0.086N     P=0.269     |P=0.077      (e)          P=0.470      P=0.273      | 
|COCH-ARM / FISHERS |     P=0.142      P=0.357N     P=0.102N     P=0.277     |P=0.071      (e)          P=0.495      P=0.247      | 
|ORDER RESTRICTED   |     P=0.046 *    (e)          (e)          (e)         |P=0.077      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/48 (2%)    1/49 (2%)    0/49 (0%)   |2/50 (4%)    0/49 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.98      1/45.28      1/45.48      0/42.80     |2/43.63      0/44.35      2/42.00      1/43.40      | 
|POLY-3 PERCENT (g) |     2.3%         2.2%         2.2%         0.0%        |4.6%         0.0%         4.8%         2.3%         | 
|TERMINAL (d)       |     1/38 (3%)    1/39 (3%)    1/40 (3%)    0/32 (0%)   |2/36 (6%)    0/34 (0%)    2/31 (7%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.345N     P=0.756N     P=0.750N     P=0.534N    |P=0.539N     P=0.251N     P=0.641      P=0.510N     | 
|POLY 3             |     P=0.319N     P=0.754N     P=0.753N     P=0.505N    |P=0.539N     P=0.233N     P=0.681      P=0.502N     | 
|POLY 1.5           |     P=0.316N     P=0.758N     P=0.755N     P=0.503N    |P=0.537N     P=0.236N     P=0.678      P=0.503N     | 
|POLY 6             |     P=0.324N     P=0.749N     P=0.751N     P=0.510N    |P=0.542N     P=0.229N     P=0.682      P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.345N     P=0.756N     P=0.750N     (e)         |P=0.539N     (e)          P=0.641      P=0.510N     | 
|COCH-ARM / FISHERS |     P=0.310N     P=0.747      P=0.753N     P=0.500N    |P=0.529N     P=0.253N     P=0.684      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.332N     (e)          (e)          (e)         |P=0.415N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Fracture                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.60      1/47.28      0/46.48      2/43.80     |0/43.63      0/45.35      1/43.33      1/43.40      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         0.0%         4.6%        |0.0%         0.0%         2.3%         2.3%         | 
|TERMINAL (d)       |     1/38 (3%)    1/41 (2%)    0/41 (0%)    2/33 (6%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |---          ---          34           729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318      P=0.745N     P=0.485N     P=0.451     |P=0.235      (e)          P=0.496      P=0.494      | 
|POLY 3             |     P=0.360      P=0.747N     P=0.492N     P=0.494     |P=0.231      (e)          P=0.499      P=0.499      | 
|POLY 1.5           |     P=0.363      P=0.752N     P=0.494N     P=0.497     |P=0.232      (e)          P=0.498      P=0.498      | 
|POLY 6             |     P=0.355      P=0.741N     P=0.489N     P=0.489     |P=0.231      (e)          P=0.498      P=0.500      | 
|LOGISTIC REGRESSION|     P=0.318      P=0.745N     (e)          P=0.451     |P=0.284      (e)          (e)          P=0.494      | 
|COCH-ARM / FISHERS |     P=0.366      P=0.753N     P=0.500N     P=0.500     |P=0.236      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.258      (e)          (e)          (e)         |P=0.250      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone                                                                                                                             | 
|     Hyperostosis                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/44.97      1/47.28      0/46.48      0/43.80     |1/43.63      1/45.35      4/42.33      3/43.40      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         0.0%         0.0%        |2.3%         2.2%         9.5%         6.9%         | 
|TERMINAL (d)       |     0/38 (0%)    1/41 (2%)    0/41 (0%)    0/33 (0%)   |1/36 (3%)    1/35 (3%)    4/31 (13%)   3/35 (9%)    | 
|FIRST INCIDENCE    |     625          729 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.246N     P=0.744N     P=0.491N     P=0.505N    |P=0.155      P=0.756      P=0.136      P=0.295      | 
|POLY 3             |     P=0.236N     P=0.749N     P=0.493N     P=0.505N    |P=0.155      P=0.752N     P=0.169      P=0.303      | 
|POLY 1.5           |     P=0.236N     P=0.753N     P=0.495N     P=0.503N    |P=0.157      P=0.755N     P=0.169      P=0.302      | 
|POLY 6             |     P=0.236N     P=0.744N     P=0.492N     P=0.509N    |P=0.155      P=0.748N     P=0.168      P=0.305      | 
|LOGISTIC REGRESSION|     P=0.233N     P=0.745      P=0.566N     P=0.494N    |P=0.155      P=0.756      P=0.136      P=0.295      | 
|COCH-ARM / FISHERS |     P=0.236N     P=0.753N     P=0.500N     P=0.500N    |P=0.164      P=0.753N     P=0.181      P=0.309      | 
|ORDER RESTRICTED   |     P=0.256N     (e)          (e)          (e)         |P=0.164      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/49 (43%)  12/50 (24%)  13/50 (26%)  15/50 (30%) |14/50 (28%)  28/50 (56%)  29/50 (58%)  31/50 (62%)  | 
|POLY-3 RATE (b)    |     21/47.37     12/48.71     13/49.20     15/46.97    |14/44.95     28/49.24     29/47.62     31/48.28     | 
|POLY-3 PERCENT (g) |     44.3%        24.6%        26.4%        31.9%       |31.2%        56.9%        60.9%        64.2%        | 
|TERMINAL (d)       |     13/38 (34%)  7/41 (17%)   6/41 (15%)   4/33 (12%)  |11/36 (31%)  16/35 (46%)  17/31 (55%)  20/35 (57%)  | 
|FIRST INCIDENCE    |     561          574          558          535         |440          461          27           142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.340N     P=0.038N*    P=0.066N     P=0.264N    |P=0.005 **   P=0.011 *    P=0.002 **   P=0.002 **   | 
|POLY 3             |     P=0.216N     P=0.033N*    P=0.050N     P=0.151N    |P=0.003 **   P=0.009 **   P=0.003 **   P<0.001 **   | 
|POLY 1.5           |     P=0.209N     P=0.034N*    P=0.053N     P=0.145N    |P=0.002 **   P=0.006 **   P=0.002 **   P<0.001 **   | 
|POLY 6             |     P=0.224N     P=0.031N*    P=0.047N*    P=0.158N    |P=0.004 **   P=0.014 *    P=0.004 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P=0.119N     P=0.051N     P=0.074N     P=0.102N    |P=0.002 **   P=0.004 **   P=0.003 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.194N     P=0.037N*    P=0.060N     P=0.131N    |P=0.002 **   P=0.004 **   P=0.002 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P=0.060N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Bone Marrow                                                                                                                      | 
|     Myelofibrosis                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.53      0/47.28      0/46.48      0/43.80     |1/43.63      2/45.35      1/42.33      2/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         4.4%         2.4%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |1/36 (3%)    2/35 (6%)    1/31 (3%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.432      P=0.490      P=0.728      P=0.490      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.438      P=0.514      P=0.754      P=0.498      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.438      P=0.509      P=0.754      P=0.497      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.438      P=0.520      P=0.754      P=0.500      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.432      P=0.490      P=0.728      P=0.490      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.444      P=0.500      P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.441      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/47 (0%)    2/47 (4%)    0/47 (0%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |                                                        |0/41.57      2/43.05      0/39.58      4/42.79      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         4.7%         0.0%         9.4%         | 
|TERMINAL (d)       |                                                        |0/34 (0%)    1/33 (3%)    0/29 (0%)    3/34 (9%)    | 
|FIRST INCIDENCE    |                                                        |---          717          ---          618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.037 *    P=0.242      (e)          P=0.066      | 
|POLY 3             |                                                        |P=0.035 *    P=0.245      (e)          P=0.063      | 
|POLY 1.5           |                                                        |P=0.035 *    P=0.241      (e)          P=0.063      | 
|POLY 6             |                                                        |P=0.035 *    P=0.250      (e)          P=0.065      | 
|LOGISTIC REGRESSION|                                                        |P=0.035 *    P=0.252      (e)          P=0.066      | 
|COCH-ARM / FISHERS |                                                        |P=0.038 *    P=0.247      (e)          P=0.064      | 
|ORDER RESTRICTED   |                                                        |P=0.012 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Atypia Cellular                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   4/50 (8%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     1/44.93      6/48.51      4/47.24      3/45.00     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         12.4%        8.5%         6.7%        |                                                    | 
|TERMINAL (d)       |     0/38 (0%)    2/41 (5%)    2/41 (5%)    0/33 (0%)   |                                                    | 
|FIRST INCIDENCE    |     638          577          562          465         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.422      P=0.083      P=0.206      P=0.306     |                                                    | 
|POLY 3             |     P=0.461      P=0.070      P=0.194      P=0.306     |                                                    | 
|POLY 1.5           |     P=0.463      P=0.064      P=0.189      P=0.306     |                                                    | 
|POLY 6             |     P=0.454      P=0.077      P=0.200      P=0.303     |                                                    | 
|LOGISTIC REGRESSION|     P=0.506      P=0.035 *    P=0.136      P=0.314     |                                                    | 
|COCH-ARM / FISHERS |     P=0.463      P=0.056      P=0.181      P=0.309     |                                                    | 
|ORDER RESTRICTED   |     P=0.166      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |3/50 (6%)    3/48 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.86      0/47.28      3/46.72      0/43.80     |3/43.63      3/44.87      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         6.4%         0.0%        |6.9%         6.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    2/41 (5%)    0/33 (0%)   |3/36 (8%)    1/35 (3%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          667          ---         |729 (T)      673          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.506      (e)          P=0.141      (e)         |P=0.039N*    P=0.656N     P=0.148N     P=0.126N     | 
|POLY 3             |     P=0.515      (e)          P=0.130      (e)         |P=0.034N*    P=0.649N     P=0.124N     P=0.119N     | 
|POLY 1.5           |     P=0.527      (e)          P=0.128      (e)         |P=0.034N*    P=0.661N     P=0.124N     P=0.120N     | 
|POLY 6             |     P=0.496      (e)          P=0.133      (e)         |P=0.034N*    P=0.634N     P=0.124N     P=0.118N     | 
|LOGISTIC REGRESSION|     P=0.539      (e)          P=0.127      (e)         |P=0.035N*    P=0.645N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.543      (e)          P=0.125      (e)         |P=0.034N*    P=0.641      P=0.121N     P=0.121N     | 
|ORDER RESTRICTED   |     P=0.174      (e)          (e)          (e)         |P=0.055N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Cornea                                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/48 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.86      0/47.28      0/46.48      0/43.80     |2/43.63      1/44.65      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.6%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |2/36 (6%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      719          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.109N     P=0.503N     P=0.272N     P=0.244N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.104N     P=0.492N     P=0.244N     P=0.238N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.103N     P=0.500N     P=0.244N     P=0.239N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.105N     P=0.482N     P=0.244N     P=0.237N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.103N     P=0.475N     (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.100N     P=0.515N     P=0.247N     P=0.247N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.075N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    3/50 (6%)    2/49 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/44.60      3/47.35      3/46.72      2/43.19     |0/43.63      0/45.35      0/42.33      0/43.00      | 
|POLY-3 PERCENT (g) |     2.2%         6.3%         6.4%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    2/41 (5%)    2/41 (5%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      713          667          711         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.414      P=0.341      P=0.340      P=0.461     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.455      P=0.327      P=0.322      P=0.489     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.460      P=0.319      P=0.316      P=0.491     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.447      P=0.338      P=0.329      P=0.486     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.449      P=0.342      P=0.318      P=0.480     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.468      P=0.309      P=0.309      P=0.492     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.357      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/49 (2%)    1/50 (2%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      2/44.73     |1/43.13      1/45.35      1/41.73      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |2.3%         2.2%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    1/35 (3%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          288         |710          729 (T)      723          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    (e)          (e)          P=0.224     |P=0.326N     P=0.755N     P=0.744      P=0.511N     | 
|POLY 3             |     P=0.044 *    (e)          (e)          P=0.238     |P=0.316N     P=0.749N     P=0.753      P=0.499N     | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.239     |P=0.315N     P=0.751N     P=0.754      P=0.498N     | 
|POLY 6             |     P=0.043 *    (e)          (e)          P=0.235     |P=0.317N     P=0.747N     P=0.753      P=0.499N     | 
|LOGISTIC REGRESSION|     P=0.071      (e)          (e)          P=0.236     |P=0.316N     P=0.748N     P=0.755      P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.309N     P=0.747N     P=0.753N     P=0.495N     | 
|ORDER RESTRICTED   |     P=0.030 *    (e)          (e)          (e)         |P=0.327N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.04      1/47.28      1/46.48      1/44.22     |0/43.05      0/45.35      0/41.71      0/43.40      | 
|POLY-3 PERCENT (g) |     4.4%         2.1%         2.2%         2.3%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    1/41 (2%)    1/41 (2%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     603          729 (T)      729 (T)      605         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.438N     P=0.477N     P=0.480N     P=0.514N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.418N     P=0.483N     P=0.489N     P=0.506N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.415N     P=0.489N     P=0.492N     P=0.503N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.424N     P=0.476N     P=0.486N     P=0.511N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.398N     P=0.521N     P=0.517N     P=0.492N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.409N     P=0.500N     P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.411N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/49 (2%)    0/50 (0%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/45.15      0/47.28      0/46.48      2/43.93     |1/43.50      0/45.35      1/41.78      2/44.24      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         4.6%        |2.3%         0.0%         2.4%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     561          ---          ---          694         |597          ---          712          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223      P=0.496N     P=0.500N     P=0.475     |P=0.246      P=0.495N     P=0.757      P=0.509      | 
|POLY 3             |     P=0.238      P=0.491N     P=0.494N     P=0.490     |P=0.247      P=0.492N     P=0.752      P=0.506      | 
|POLY 1.5           |     P=0.241      P=0.494N     P=0.496N     P=0.495     |P=0.247      P=0.493N     P=0.753      P=0.505      | 
|POLY 6             |     P=0.233      P=0.487N     P=0.493N     P=0.484     |P=0.247      P=0.490N     P=0.750      P=0.508      | 
|LOGISTIC REGRESSION|     P=0.264      P=0.613N     P=0.640N     P=0.506     |P=0.266      P=0.550N     P=0.756N     P=0.541      | 
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.500N     P=0.500     |P=0.251      P=0.495N     P=0.753N     P=0.508      | 
|ORDER RESTRICTED   |     P=0.122      (e)          (e)          (e)         |P=0.228      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    3/49 (6%)    4/49 (8%)    2/48 (4%)   |4/44 (9%)    6/47 (13%)   6/47 (13%)   6/47 (13%)   | 
|POLY-3 RATE (b)    |     1/43.16      3/46.28      4/45.72      2/42.79     |4/40.25      6/43.71      6/40.59      6/42.42      | 
|POLY-3 PERCENT (g) |     2.3%         6.5%         8.8%         4.7%        |9.9%         13.7%        14.8%        14.1%        | 
|TERMINAL (d)       |     1/38 (3%)    3/40 (8%)    4/41 (10%)   1/33 (3%)   |4/36 (11%)   5/35 (14%)   3/31 (10%)   3/35 (9%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      640         |729 (T)      706          712          618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.391      P=0.324      P=0.203      P=0.470     |P=0.333      P=0.360      P=0.297      P=0.371      | 
|POLY 3             |     P=0.438      P=0.331      P=0.196      P=0.497     |P=0.368      P=0.422      P=0.374      P=0.403      | 
|POLY 1.5           |     P=0.445      P=0.326      P=0.195      P=0.500     |P=0.370      P=0.420      P=0.381      P=0.403      | 
|POLY 6             |     P=0.428      P=0.337      P=0.198      P=0.494     |P=0.371      P=0.423      P=0.362      P=0.406      | 
|LOGISTIC REGRESSION|     P=0.432      P=0.324      P=0.203      P=0.506     |P=0.353      P=0.410      P=0.340      P=0.398      | 
|COCH-ARM / FISHERS |     P=0.462      P=0.324      P=0.194      P=0.508     |P=0.386      P=0.413      P=0.413      P=0.413      | 
|ORDER RESTRICTED   |     P=0.300      (e)          (e)          (e)         |P=0.434      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Duodenum: Epithelium                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    1/49 (2%)    1/49 (2%)   |0/46 (0%)    0/47 (0%)    2/47 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      1/45.72      1/43.22     |0/41.64      0/43.62      2/40.85      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         2.3%        |0.0%         0.0%         4.9%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      729 (T)     |---          ---          662          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.202      (e)          P=0.515      P=0.472     |P=0.593      (e)          P=0.230      (e)          | 
|POLY 3             |     P=0.223      (e)          P=0.508      P=0.497     |P=0.586      (e)          P=0.233      (e)          | 
|POLY 1.5           |     P=0.228      (e)          P=0.506      P=0.499     |P=0.594      (e)          P=0.233      (e)          | 
|POLY 6             |     P=0.216      (e)          P=0.510      P=0.494     |P=0.579      (e)          P=0.233      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.515      P=0.472     |P=0.610      (e)          P=0.238      (e)          | 
|COCH-ARM / FISHERS |     P=0.236      (e)          P=0.505      P=0.505     |P=0.611      (e)          P=0.253      (e)          | 
|ORDER RESTRICTED   |     P=0.248      (e)          (e)          (e)         |P=0.243      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small, Jejunum: Epithelium                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/49 (0%)    0/50 (0%)    2/50 (4%)   |0/45 (0%)    0/47 (0%)    0/47 (0%)    0/47 (0%)    | 
|POLY-3 RATE (b)    |     0/43.09      0/47.07      0/46.48      2/43.80     |0/41.46      0/42.98      0/40.58      0/41.27      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    2/33 (6%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    (e)          (e)          P=0.208     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.045 *    (e)          (e)          P=0.241     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.046 *    (e)          (e)          P=0.244     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.044 *    (e)          (e)          P=0.235     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.208     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.049 *    (e)          (e)          P=0.263     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.031 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     31/48 (65%)  25/50 (50%)  28/50 (56%)  23/50 (46%) |9/46 (20%)   6/47 (13%)   4/49 (8%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     31/47.31     25/47.34     28/47.73     23/45.15    |9/42.91      6/45.01      4/42.51      3/43.04      | 
|POLY-3 PERCENT (g) |     65.5%        52.8%        58.7%        51.0%       |21.0%        13.3%        9.4%         7.0%         | 
|TERMINAL (d)       |     23/38 (61%)  23/41 (56%)  24/41 (59%)  19/33 (58%) |8/36 (22%)   5/35 (14%)   3/31 (10%)   2/35 (6%)    | 
|FIRST INCIDENCE    |     484          721          543          535         |524          461          574          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311N     P=0.095N     P=0.230N     P=0.235N    |P=0.048N*    P=0.305N     P=0.177N     P=0.068N     | 
|POLY 3             |     P=0.139N     P=0.144N     P=0.315N     P=0.108N    |P=0.039N*    P=0.252N     P=0.116N     P=0.057N     | 
|POLY 1.5           |     P=0.109N     P=0.127N     P=0.289N     P=0.080N    |P=0.036N*    P=0.261N     P=0.113N     P=0.055N     | 
|POLY 6             |     P=0.187N     P=0.166N     P=0.349N     P=0.155N    |P=0.041N*    P=0.241N     P=0.120N     P=0.058N     | 
|LOGISTIC REGRESSION|     P=0.102N     P=0.097N     P=0.256N     P=0.059N    |P=0.032N*    P=0.285N     P=0.106N     P=0.055N     | 
|COCH-ARM / FISHERS |     P=0.072N     P=0.105N     P=0.254N     P=0.050N    |P=0.030N*    P=0.272N     P=0.093N     P=0.047N*    | 
|ORDER RESTRICTED   |     P=0.117N     (e)          (e)          (e)         |P=0.035N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/49 (29%)  10/50 (20%)  9/50 (18%)   10/50 (20%) |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     14/44.65     10/47.71     9/46.69      10/43.80    |0/43.63      0/44.92      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     31.4%        21.0%        19.3%        22.8%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     13/38 (34%)  9/41 (22%)   8/41 (20%)   10/33 (30%) |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     699          604          673          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.365N     P=0.178N     P=0.123N     P=0.371N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.258N     P=0.183N     P=0.137N     P=0.253N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.244N     P=0.201N     P=0.145N     P=0.243N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.280N     P=0.160N     P=0.127N     P=0.268N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.292N     P=0.166N     P=0.123N     P=0.304N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.220N     P=0.224N     P=0.157N     P=0.224N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.201N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hydronephrosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/49 (0%)    1/49 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.53      2/47.79      2/46.91      1/43.80     |0/43.63      0/44.92      1/42.00      1/44.16      | 
|POLY-3 PERCENT (g) |     2.3%         4.2%         4.3%         2.3%        |0.0%         0.0%         2.4%         2.3%         | 
|TERMINAL (d)       |     1/38 (3%)    1/41 (2%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      574          672          729 (T)     |---          ---          729 (T)      455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.596N     P=0.527      P=0.529      P=0.730     |P=0.234      (e)          P=0.470      P=0.500      | 
|POLY 3             |     P=0.567N     P=0.525      P=0.518      P=0.757     |P=0.237      (e)          P=0.492      P=0.502      | 
|POLY 1.5           |     P=0.561N     P=0.517      P=0.513      P=0.760     |P=0.237      (e)          P=0.491      P=0.501      | 
|POLY 6             |     P=0.575N     P=0.536      P=0.525      P=0.754     |P=0.238      (e)          P=0.493      P=0.505      | 
|LOGISTIC REGRESSION|     P=0.520N     P=0.485      P=0.496      P=0.730     |P=0.253      (e)          P=0.470      P=0.577      | 
|COCH-ARM / FISHERS |     P=0.550N     P=0.508      P=0.508      P=0.747N    |P=0.237      (e)          P=0.495      P=0.500      | 
|ORDER RESTRICTED   |     P=0.567      (e)          (e)          (e)         |P=0.243      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/49 (16%)   6/50 (12%)   4/50 (8%)    11/50 (22%) |8/50 (16%)   9/49 (18%)   6/49 (12%)   8/50 (16%)   | 
|POLY-3 RATE (b)    |     8/45.08      6/47.28      4/46.72      11/44.04    |8/44.52      9/45.48      6/42.00      8/44.17      | 
|POLY-3 PERCENT (g) |     17.8%        12.7%        8.6%         25.0%       |18.0%        19.8%        14.3%        18.1%        | 
|TERMINAL (d)       |     7/38 (18%)   6/41 (15%)   3/41 (7%)    10/33 (30%) |6/36 (17%)   5/35 (14%)   6/31 (19%)   7/35 (20%)   | 
|FIRST INCIDENCE    |     561          729 (T)      667          664         |591          673          729 (T)      447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.114      P=0.332N     P=0.147N     P=0.203     |P=0.516N     P=0.507      P=0.491N     P=0.588      | 
|POLY 3             |     P=0.180      P=0.350N     P=0.159N     P=0.283     |P=0.505N     P=0.519      P=0.432N     P=0.602      | 
|POLY 1.5           |     P=0.190      P=0.360N     P=0.163N     P=0.297     |P=0.500N     P=0.506      P=0.429N     P=0.601      | 
|POLY 6             |     P=0.168      P=0.335N     P=0.154N     P=0.266     |P=0.515N     P=0.539      P=0.440N     P=0.600      | 
|LOGISTIC REGRESSION|     P=0.165      P=0.340N     P=0.163N     P=0.278     |P=0.501N     P=0.507      P=0.415N     P=0.604      | 
|COCH-ARM / FISHERS |     P=0.207      P=0.371N     P=0.168N     P=0.323     |P=0.483N     P=0.482      P=0.403N     P=0.607N     | 
|ORDER RESTRICTED   |     P=0.093      (e)          (e)          (e)         |P=0.582N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   1/50 (2%)    4/50 (8%)    5/50 (10%)  |3/50 (6%)    2/49 (4%)    4/49 (8%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     5/45.08      1/47.28      4/46.48      5/44.54     |3/43.63      2/45.13      4/42.43      5/43.40      | 
|POLY-3 PERCENT (g) |     11.1%        2.1%         8.6%         11.2%       |6.9%         4.4%         9.4%         11.5%        | 
|TERMINAL (d)       |     4/38 (11%)   1/41 (2%)    4/41 (10%)   3/33 (9%)   |3/36 (8%)    1/35 (3%)    2/31 (7%)    5/35 (14%)   | 
|FIRST INCIDENCE    |     561          729 (T)      729 (T)      595         |729 (T)      673          618          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.302      P=0.091N     P=0.458N     P=0.564     |P=0.192      P=0.497N     P=0.440      P=0.339      | 
|POLY 3             |     P=0.359      P=0.091N     P=0.481N     P=0.623     |P=0.190      P=0.485N     P=0.485      P=0.353      | 
|POLY 1.5           |     P=0.368      P=0.094N     P=0.484N     P=0.629     |P=0.193      P=0.494N     P=0.479      P=0.352      | 
|POLY 6             |     P=0.347      P=0.086N     P=0.477N     P=0.617     |P=0.186      P=0.472N     P=0.490      P=0.356      | 
|LOGISTIC REGRESSION|     P=0.381      P=0.102N     P=0.480N     P=0.612N    |P=0.190      P=0.479N     P=0.479      P=0.339      | 
|COCH-ARM / FISHERS |     P=0.384      P=0.098N     P=0.487N     P=0.617N    |P=0.202      P=0.510N     P=0.489      P=0.357      | 
|ORDER RESTRICTED   |     P=0.331      (e)          (e)          (e)         |P=0.249      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   5/50 (10%)   3/50 (6%)    4/50 (8%)   |0/50 (0%)    1/49 (2%)    3/49 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     7/44.53      5/47.31      3/46.48      4/43.80     |0/43.63      1/44.92      3/42.26      2/43.40      | 
|POLY-3 PERCENT (g) |     15.7%        10.6%        6.5%         9.1%        |0.0%         2.2%         7.1%         4.6%         | 
|TERMINAL (d)       |     7/38 (18%)   4/41 (10%)   3/41 (7%)    4/33 (12%)  |0/36 (0%)    1/35 (3%)    2/31 (7%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      722          729 (T)      729 (T)     |---          729 (T)      661          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.266N     P=0.326N     P=0.128N     P=0.345N    |P=0.161      P=0.494      P=0.107      P=0.232      | 
|POLY 3             |     P=0.206N     P=0.337N     P=0.140N     P=0.270N    |P=0.159      P=0.506      P=0.113      P=0.236      | 
|POLY 1.5           |     P=0.200N     P=0.350N     P=0.144N     P=0.263N    |P=0.160      P=0.502      P=0.112      P=0.235      | 
|POLY 6             |     P=0.214N     P=0.319N     P=0.135N     P=0.278N    |P=0.158      P=0.511      P=0.114      P=0.237      | 
|LOGISTIC REGRESSION|     P=0.249N     P=0.296N     P=0.128N     P=0.345N    |P=0.158      P=0.494      P=0.114      P=0.232      | 
|COCH-ARM / FISHERS |     P=0.188N     P=0.365N     P=0.151N     P=0.251N    |P=0.165      P=0.495      P=0.117      P=0.247      | 
|ORDER RESTRICTED   |     P=0.177N     (e)          (e)          (e)         |P=0.103      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     37/49 (76%)  42/50 (84%)  43/50 (86%)  36/50 (72%) |14/50 (28%)  11/49 (22%)  14/49 (29%)  12/50 (24%)  | 
|POLY-3 RATE (b)    |     37/46.38     42/49.82     43/48.44     36/48.20    |14/44.50     11/45.25     14/42.93     12/45.15     | 
|POLY-3 PERCENT (g) |     79.8%        84.3%        88.8%        74.7%       |31.5%        24.3%        32.6%        26.6%        | 
|TERMINAL (d)       |     33/38 (87%)  36/41 (88%)  38/41 (93%)  25/33 (76%) |11/36 (31%)  7/35 (20%)   10/31 (32%)  8/35 (23%)   | 
|FIRST INCIDENCE    |     561          431          558          288         |591          673          602          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.265      P=0.407      P=0.301      P=0.332     |P=0.487N     P=0.333N     P=0.444      P=0.436N     | 
|POLY 3             |     P=0.244N     P=0.373      P=0.162      P=0.361N    |P=0.440N     P=0.301N     P=0.546      P=0.391N     | 
|POLY 1.5           |     P=0.256N     P=0.296      P=0.151      P=0.390N    |P=0.447N     P=0.316N     P=0.537      P=0.403N     | 
|POLY 6             |     P=0.236N     P=0.488      P=0.185      P=0.325N    |P=0.433N     P=0.283N     P=0.551      P=0.377N     | 
|LOGISTIC REGRESSION|     P=0.349N     P=0.251      P=0.177      P=0.481N    |P=0.464N     P=0.280N     P=0.543      P=0.416N     | 
|COCH-ARM / FISHERS |     P=0.281N     P=0.212      P=0.142      P=0.433N    |P=0.440N     P=0.343N     P=0.563      P=0.410N     | 
|ORDER RESTRICTED   |     P=0.160N     (e)          (e)          (e)         |P=0.478N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |2/50 (4%)    1/49 (2%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.53      1/47.35      1/46.71      0/43.80     |2/44.09      1/44.98      2/42.07      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.1%         0.0%        |4.5%         2.2%         4.8%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |1/36 (3%)    0/35 (0%)    1/31 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          713          668          ---         |591          713          712          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.621N     P=0.529      P=0.524      (e)         |P=0.461N     P=0.494N     P=0.659      P=0.509N     | 
|POLY 3             |     P=0.600N     P=0.512      P=0.510      (e)         |P=0.457N     P=0.493N     P=0.677      P=0.506N     | 
|POLY 1.5           |     P=0.597N     P=0.508      P=0.507      (e)         |P=0.453N     P=0.498N     P=0.677      P=0.505N     | 
|POLY 6             |     P=0.604N     P=0.518      P=0.513      (e)         |P=0.460N     P=0.487N     P=0.676      P=0.506N     | 
|LOGISTIC REGRESSION|     P=0.581N     P=0.509      P=0.486      (e)         |P=0.448N     P=0.523N     P=0.684      P=0.500N     | 
|COCH-ARM / FISHERS |     P=0.592N     P=0.505      P=0.505      (e)         |P=0.443N     P=0.508N     P=0.684      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.412      (e)          (e)          (e)         |P=0.450N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    2/50 (4%)    0/50 (0%)    3/50 (6%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.53      2/47.82      0/46.48      3/44.96     |1/44.13      0/44.92      0/42.00      1/44.16      | 
|POLY-3 PERCENT (g) |     2.3%         4.2%         0.0%         6.7%        |2.3%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      574          ---          570         |576          ---          ---          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.222      P=0.530      P=0.485N     P=0.298     |P=0.587      P=0.513N     P=0.518N     P=0.753      | 
|POLY 3             |     P=0.242      P=0.525      P=0.491N     P=0.309     |P=0.589      P=0.496N     P=0.510N     P=0.761N     | 
|POLY 1.5           |     P=0.243      P=0.517      P=0.493N     P=0.309     |P=0.590      P=0.499N     P=0.510N     P=0.760      | 
|POLY 6             |     P=0.241      P=0.536      P=0.489N     P=0.309     |P=0.587      P=0.493N     P=0.511N     P=0.760N     | 
|LOGISTIC REGRESSION|     P=0.335      P=0.484      (e)          P=0.365     |P=0.650      P=0.583N     P=0.464N     P=0.723N     | 
|COCH-ARM / FISHERS |     P=0.246      P=0.508      P=0.495N     P=0.316     |P=0.595      P=0.505N     P=0.505N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.183      (e)          (e)          (e)         |P=0.401N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/49 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.08      0/47.28      0/46.48      2/44.49     |1/43.88      0/44.92      0/42.00      1/43.85      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         4.5%        |2.3%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     561          ---          ---          605         |660          ---          ---          597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.238      P=0.496N     P=0.500N     P=0.494     |P=0.597      P=0.476N     P=0.500N     P=0.752N     | 
|POLY 3             |     P=0.241      P=0.490N     P=0.494N     P=0.495     |P=0.588      P=0.495N     P=0.509N     P=0.761      | 
|POLY 1.5           |     P=0.244      P=0.493N     P=0.495N     P=0.499     |P=0.590      P=0.498N     P=0.509N     P=0.759      | 
|POLY 6             |     P=0.238      P=0.486N     P=0.493N     P=0.492     |P=0.586      P=0.492N     P=0.509N     P=0.759N     | 
|LOGISTIC REGRESSION|     P=0.368      P=0.480N     P=0.611N     P=0.613     |P=0.611      P=0.524N     P=0.499N     P=0.752N     | 
|COCH-ARM / FISHERS |     P=0.249      P=0.495N     P=0.495N     P=0.508     |P=0.595      P=0.505N     P=0.505N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.126      (e)          (e)          (e)         |P=0.401      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)   |3/50 (6%)    1/49 (2%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.53      2/47.85      1/46.71      1/43.80     |3/43.63      1/44.92      0/42.00      1/44.39      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         2.1%         2.3%        |6.9%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    1/33 (3%)   |3/36 (8%)    1/35 (3%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          577          668          729 (T)     |729 (T)      729 (T)      ---          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.472      P=0.263      P=0.524      P=0.472     |P=0.211N     P=0.315N     P=0.148N     P=0.314N     | 
|POLY 3             |     P=0.488      P=0.254      P=0.510      P=0.497     |P=0.205N     P=0.295N     P=0.125N     P=0.299N     | 
|POLY 1.5           |     P=0.494      P=0.248      P=0.507      P=0.499     |P=0.204N     P=0.301N     P=0.126N     P=0.301N     | 
|POLY 6             |     P=0.481      P=0.261      P=0.513      P=0.493     |P=0.207N     P=0.286N     P=0.125N     P=0.296N     | 
|LOGISTIC REGRESSION|     P=0.548      P=0.222      P=0.486      P=0.472     |P=0.174N     P=0.315N     (e)          P=0.260N     | 
|COCH-ARM / FISHERS |     P=0.505      P=0.253      P=0.505      P=0.505     |P=0.200N     P=0.316N     P=0.125N     P=0.309N     | 
|ORDER RESTRICTED   |     P=0.288      (e)          (e)          (e)         |P=0.079N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |2/49 (4%)    0/50 (0%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/43.91      2/47.28      0/46.48      0/43.80     |2/43.57      0/45.35      2/42.07      1/43.40      | 
|POLY-3 PERCENT (g) |     4.6%         4.2%         0.0%         0.0%        |4.6%         0.0%         4.8%         2.3%         | 
|TERMINAL (d)       |     2/38 (5%)    2/41 (5%)    0/41 (0%)    0/33 (0%)   |2/36 (6%)    0/35 (0%)    1/31 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |729 (T)      ---          711          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096N     P=0.667N     P=0.222N     P=0.270N    |P=0.544N     P=0.244N     P=0.653      P=0.510N     | 
|POLY 3             |     P=0.084N     P=0.667N     P=0.225N     P=0.238N    |P=0.538N     P=0.228N     P=0.682      P=0.501N     | 
|POLY 1.5           |     P=0.083N     P=0.672N     P=0.226N     P=0.234N    |P=0.536N     P=0.231N     P=0.680      P=0.501N     | 
|POLY 6             |     P=0.085N     P=0.659N     P=0.223N     P=0.242N    |P=0.541N     P=0.224N     P=0.683      P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.096N     P=0.667N     (e)          (e)         |P=0.541N     (e)          P=0.681      P=0.510N     | 
|COCH-ARM / FISHERS |     P=0.082N     P=0.676N     P=0.237N     P=0.237N    |P=0.526N     P=0.242N     P=0.691N     P=0.492N     | 
|ORDER RESTRICTED   |     P=0.116N     (e)          (e)          (e)         |P=0.414N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    2/50 (4%)    3/50 (6%)    4/50 (8%)   |5/49 (10%)   0/50 (0%)    4/49 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.91      2/47.28      3/46.93      4/44.19     |5/43.57      0/45.35      4/42.00      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         6.4%         9.1%        |11.5%        0.0%         9.5%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    2/41 (5%)    1/41 (2%)    3/33 (9%)   |5/36 (14%)   0/35 (0%)    4/31 (13%)   1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      667          616         |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.032 *    P=0.255      P=0.142      P=0.052     |P=0.174N     P=0.035N*    P=0.595N     P=0.108N     | 
|POLY 3             |     P=0.044 *    P=0.254      P=0.131      P=0.061     |P=0.166N     P=0.027N*    P=0.523N     P=0.102N     | 
|POLY 1.5           |     P=0.046 *    P=0.251      P=0.129      P=0.062     |P=0.164N     P=0.028N*    P=0.524N     P=0.102N     | 
|POLY 6             |     P=0.042 *    P=0.259      P=0.134      P=0.059     |P=0.169N     P=0.026N*    P=0.523N     P=0.100N     | 
|LOGISTIC REGRESSION|     P=0.050      P=0.255      P=0.121      P=0.066     |P=0.174N     (e)          P=0.595N     P=0.108N     | 
|COCH-ARM / FISHERS |     P=0.051      P=0.258      P=0.129      P=0.064     |P=0.158N     P=0.027N*    P=0.500N     P=0.098N     | 
|ORDER RESTRICTED   |     P=0.036 *    (e)          (e)          (e)         |P=0.044N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/48 (25%)  19/50 (38%)  19/50 (38%)  13/50 (26%) |3/49 (6%)    0/50 (0%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     12/43.91     19/47.28     19/47.28     13/43.80    |3/44.61      0/45.35      1/42.71      0/43.40      | 
|POLY-3 PERCENT (g) |     27.3%        40.2%        40.2%        29.7%       |6.7%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     12/38 (32%)  19/41 (46%)  17/41 (42%)  13/33 (39%) |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      543          729 (T)     |576          ---          486          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.372      P=0.135      P=0.143      P=0.332     |P=0.093N     P=0.122N     P=0.319N     P=0.130N     | 
|POLY 3             |     P=0.523N     P=0.140      P=0.140      P=0.497     |P=0.086N     P=0.116N     P=0.321N     P=0.123N     | 
|POLY 1.5           |     P=0.494N     P=0.131      P=0.132      P=0.515     |P=0.086N     P=0.116N     P=0.320N     P=0.122N     | 
|POLY 6             |     P=0.518      P=0.155      P=0.151      P=0.472     |P=0.087N     P=0.115N     P=0.324N     P=0.125N     | 
|LOGISTIC REGRESSION|     P=0.483      P=0.135      P=0.134      P=0.332     |P=0.058N     P=0.114N     P=0.215N     P=0.085N     | 
|COCH-ARM / FISHERS |     P=0.444N     P=0.122      P=0.122      P=0.547     |P=0.085N     P=0.117N     P=0.309N     P=0.117N     | 
|ORDER RESTRICTED   |     P=0.280      (e)          (e)          (e)         |P=0.022N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/48 (23%)  10/50 (20%)  5/50 (10%)   11/50 (22%) |9/49 (18%)   9/50 (18%)   13/49 (27%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     11/45.46     10/47.78     5/46.48      11/45.22    |9/44.16      9/45.64      13/42.96     7/43.79      | 
|POLY-3 PERCENT (g) |     24.2%        20.9%        10.8%        24.3%       |20.4%        19.7%        30.3%        16.0%        | 
|TERMINAL (d)       |     7/38 (18%)   8/41 (20%)   5/41 (12%)   7/33 (21%)  |7/36 (19%)   6/35 (17%)   11/31 (36%)  6/35 (17%)   | 
|FIRST INCIDENCE    |     561          604          729 (T)      535         |639          682          486          618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.464      P=0.424N     P=0.071N     P=0.493     |P=0.413N     P=0.596N     P=0.148      P=0.405N     | 
|POLY 3             |     P=0.522N     P=0.449N     P=0.075N     P=0.591     |P=0.405N     P=0.573N     P=0.207      P=0.399N     | 
|POLY 1.5           |     P=0.506N     P=0.454N     P=0.073N     P=0.584N    |P=0.399N     P=0.579N     P=0.206      P=0.396N     | 
|POLY 6             |     P=0.544N     P=0.442N     P=0.080N     P=0.567     |P=0.409N     P=0.562N     P=0.206      P=0.398N     | 
|LOGISTIC REGRESSION|     P=0.473N     P=0.476N     P=0.075N     P=0.533N    |P=0.400N     P=0.558N     P=0.204      P=0.393N     | 
|COCH-ARM / FISHERS |     P=0.480N     P=0.458N     P=0.072N     P=0.553N    |P=0.367N     P=0.584N     P=0.234      P=0.376N     | 
|ORDER RESTRICTED   |     P=0.337N     (e)          (e)          (e)         |P=0.316N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    0/50 (0%)    4/50 (8%)   |7/49 (14%)   4/50 (8%)    3/49 (6%)    8/50 (16%)   | 
|POLY-3 RATE (b)    |     1/44.16      0/47.28      0/46.48      4/45.25     |7/44.79      4/46.31      3/42.39      8/44.56      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         8.8%        |15.6%        8.6%         7.1%         18.0%        | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    1/33 (3%)   |4/36 (11%)   2/35 (6%)    2/31 (7%)    6/35 (17%)   | 
|FIRST INCIDENCE    |     661          ---          ---          535         |591          461          618          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.024 *    P=0.477N     P=0.481N     P=0.174     |P=0.342      P=0.263N     P=0.206N     P=0.491      | 
|POLY 3             |     P=0.026 *    P=0.486N     P=0.490N     P=0.186     |P=0.336      P=0.242N     P=0.180N     P=0.496      | 
|POLY 1.5           |     P=0.027 *    P=0.489N     P=0.491N     P=0.187     |P=0.344      P=0.246N     P=0.177N     P=0.503      | 
|POLY 6             |     P=0.026 *    P=0.483N     P=0.489N     P=0.184     |P=0.327      P=0.237N     P=0.184N     P=0.488      | 
|LOGISTIC REGRESSION|     P=0.059      P=0.503N     P=0.512N     P=0.256     |P=0.389      P=0.257N     P=0.157N     P=0.560      | 
|COCH-ARM / FISHERS |     P=0.029 *    P=0.490N     P=0.490N     P=0.194     |P=0.361      P=0.251N     P=0.159N     P=0.517      | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |P=0.222      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |4/49 (8%)    7/50 (14%)   3/49 (6%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/43.91      1/47.28      1/46.48      0/43.80     |4/43.57      7/45.45      3/42.00      5/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.2%         0.0%        |9.2%         15.4%        7.1%         11.5%        | 
|TERMINAL (d)       |     0/38 (0%)    1/41 (2%)    1/41 (2%)    0/33 (0%)   |4/36 (11%)   6/35 (17%)   3/31 (10%)   5/35 (14%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |729 (T)      706          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.631N     P=0.515      P=0.515      (e)         |P=0.554      P=0.251      P=0.582N     P=0.482      | 
|POLY 3             |     P=0.599N     P=0.515      P=0.511      (e)         |P=0.562N     P=0.285      P=0.520N     P=0.497      | 
|POLY 1.5           |     P=0.595N     P=0.512      P=0.510      (e)         |P=0.559N     P=0.279      P=0.521N     P=0.498      | 
|POLY 6             |     P=0.604N     P=0.519      P=0.513      (e)         |P=0.562N     P=0.296      P=0.520N     P=0.500      | 
|LOGISTIC REGRESSION|     (e)          P=0.515      P=0.515      (e)         |P=0.552      P=0.302      P=0.582N     P=0.482      | 
|COCH-ARM / FISHERS |     P=0.589N     P=0.510      P=0.510      (e)         |P=0.539N     P=0.274      P=0.500N     P=0.513      | 
|ORDER RESTRICTED   |     P=0.414      (e)          (e)          (e)         |P=0.516N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Infiltration Cellular Mixed Cell                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |7/49 (14%)   7/50 (14%)   8/49 (16%)   7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/43.91      1/47.28      1/46.48      0/43.80     |7/43.78      7/45.35      8/42.74      7/43.70      | 
|POLY-3 PERCENT (g) |     4.6%         2.1%         2.2%         0.0%        |16.0%        15.4%        18.7%        16.0%        | 
|TERMINAL (d)       |     2/38 (5%)    1/41 (2%)    1/41 (2%)    0/33 (0%)   |6/36 (17%)   7/35 (20%)   6/31 (19%)   6/35 (17%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      ---         |674          729 (T)      486          646          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.171N     P=0.473N     P=0.473N     P=0.270N    |P=0.512      P=0.601      P=0.396      P=0.601      | 
|POLY 3             |     P=0.155N     P=0.474N     P=0.480N     P=0.238N    |P=0.525      P=0.586N     P=0.480      P=0.613      | 
|POLY 1.5           |     P=0.152N     P=0.480N     P=0.482N     P=0.234N    |P=0.527      P=0.592N     P=0.475      P=0.612      | 
|POLY 6             |     P=0.159N     P=0.467N     P=0.478N     P=0.242N    |P=0.527      P=0.577N     P=0.483      P=0.612N     | 
|LOGISTIC REGRESSION|     P=0.171N     P=0.473N     P=0.473N     (e)         |P=0.522      P=0.556N     P=0.470      P=0.614N     | 
|COCH-ARM / FISHERS |     P=0.147N     P=0.485N     P=0.485N     P=0.237N    |P=0.552      P=0.597N     P=0.500      P=0.597N     | 
|ORDER RESTRICTED   |     P=0.118N     (e)          (e)          (e)         |P=0.646      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    9/50 (18%)   8/50 (16%)   7/50 (14%)  |7/49 (14%)   2/50 (4%)    3/49 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/44.62      9/47.31      8/46.48      7/44.08     |7/43.57      2/45.39      3/42.00      3/43.50      | 
|POLY-3 PERCENT (g) |     4.5%         19.0%        17.2%        15.9%       |16.1%        4.4%         7.1%         6.9%         | 
|TERMINAL (d)       |     1/38 (3%)    8/41 (20%)   8/41 (20%)   6/33 (18%)  |7/36 (19%)   1/35 (3%)    3/31 (10%)   2/35 (6%)    | 
|FIRST INCIDENCE    |     484          722          729 (T)      652         |729 (T)      719          729 (T)      705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.103      P=0.039 *    P=0.061      P=0.059     |P=0.188N     P=0.087N     P=0.221N     P=0.170N     | 
|POLY 3             |     P=0.155      P=0.032 *    P=0.052      P=0.075     |P=0.176N     P=0.069N     P=0.171N     P=0.157N     | 
|POLY 1.5           |     P=0.168      P=0.031 *    P=0.052      P=0.080     |P=0.174N     P=0.072N     P=0.173N     P=0.158N     | 
|POLY 6             |     P=0.140      P=0.034 *    P=0.052      P=0.070     |P=0.177N     P=0.064N     P=0.169N     P=0.153N     | 
|LOGISTIC REGRESSION|     P=0.159      P=0.031 *    P=0.054      P=0.092     |P=0.181N     P=0.064N     P=0.221N     P=0.156N     | 
|COCH-ARM / FISHERS |     P=0.195      P=0.030 *    P=0.053      P=0.090     |P=0.165N     P=0.075N     P=0.159N     P=0.151N     | 
|ORDER RESTRICTED   |     P=0.061      (e)          (e)          (e)         |P=0.072N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis Focal                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/48 (8%)    6/50 (12%)   7/50 (14%)   6/50 (12%)  |5/49 (10%)   1/50 (2%)    4/49 (8%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/44.45      6/48.82      7/47.47      6/44.80     |5/44.28      1/45.35      4/42.03      1/43.57      | 
|POLY-3 PERCENT (g) |     9.0%         12.3%        14.8%        13.4%       |11.3%        2.2%         9.5%         2.3%         | 
|TERMINAL (d)       |     3/38 (8%)    3/41 (7%)    4/41 (10%)   2/33 (6%)   |3/36 (8%)    1/35 (3%)    3/31 (10%)   0/35 (0%)    | 
|FIRST INCIDENCE    |     562          431          570          570         |597          729 (T)      723          685          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.275      P=0.423      P=0.315      P=0.327     |P=0.148N     P=0.106N     P=0.569N     P=0.107N     | 
|POLY 3             |     P=0.325      P=0.430      P=0.300      P=0.374     |P=0.142N     P=0.096N     P=0.533N     P=0.105N     | 
|POLY 1.5           |     P=0.338      P=0.416      P=0.294      P=0.381     |P=0.140N     P=0.097N     P=0.529N     P=0.103N     | 
|POLY 6             |     P=0.310      P=0.448      P=0.309      P=0.367     |P=0.143N     P=0.094N     P=0.539N     P=0.105N     | 
|LOGISTIC REGRESSION|     P=0.456      P=0.327      P=0.264      P=0.417     |P=0.140N     P=0.099N     P=0.521N     P=0.098N     | 
|COCH-ARM / FISHERS |     P=0.362      P=0.397      P=0.286      P=0.397     |P=0.132N     P=0.098N     P=0.500N     P=0.098N     | 
|ORDER RESTRICTED   |     P=0.378      (e)          (e)          (e)         |P=0.058N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Tension Lipidosis                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |2/49 (4%)    3/50 (6%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/43.91      0/47.28      1/46.48      0/43.80     |2/43.57      3/45.45      0/42.00      1/43.40      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.2%         0.0%        |4.6%         6.6%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |2/36 (6%)    2/35 (6%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |729 (T)      706          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.434N     P=0.485N     P=0.745N     P=0.528N    |P=0.258N     P=0.499      P=0.272N     P=0.510N     | 
|POLY 3             |     P=0.410N     P=0.485N     P=0.748N     P=0.501N    |P=0.245N     P=0.519      P=0.245N     P=0.501N     | 
|POLY 1.5           |     P=0.405N     P=0.488N     P=0.749N     P=0.497N    |P=0.245N     P=0.514      P=0.246N     P=0.501N     | 
|POLY 6             |     P=0.415N     P=0.481N     P=0.746N     P=0.505N    |P=0.245N     P=0.528      P=0.245N     P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.434N     (e)          P=0.745N     (e)         |P=0.249N     P=0.533      (e)          P=0.510N     | 
|COCH-ARM / FISHERS |     P=0.398N     P=0.490N     P=0.742N     P=0.490N    |P=0.238N     P=0.510      P=0.247N     P=0.492N     | 
|ORDER RESTRICTED   |     P=0.252N     (e)          (e)          (e)         |P=0.200N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      0/46.48      2/44.06     |0/43.57      0/45.35      0/42.00      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          657         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.036 *    (e)          (e)          P=0.219     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.044 *    (e)          (e)          P=0.238     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.241     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.043 *    (e)          (e)          P=0.234     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.050      (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.048 *    (e)          (e)          P=0.258     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.030 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |2/49 (4%)    2/50 (4%)    2/49 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.45      0/47.28      0/46.48      2/44.50     |2/44.11      2/45.41      2/42.30      2/44.60      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         4.5%        |4.5%         4.4%         4.7%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    1/35 (3%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     561          ---          ---          595         |639          714          661          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.238      P=0.496N     P=0.500N     P=0.497     |P=0.586      P=0.667N     P=0.684      P=0.688N     | 
|POLY 3             |     P=0.244      P=0.488N     P=0.491N     P=0.500     |P=0.594      P=0.683N     P=0.679      P=0.690N     | 
|POLY 1.5           |     P=0.247      P=0.490N     P=0.491N     P=0.505     |P=0.593      P=0.685N     P=0.679      P=0.691N     | 
|POLY 6             |     P=0.241      P=0.485N     P=0.491N     P=0.495     |P=0.596N     P=0.681N     P=0.678      P=0.688N     | 
|LOGISTIC REGRESSION|     P=0.376      P=0.473N     P=0.604N     P=0.626     |P=0.563N     P=0.691N     P=0.690N     P=0.602N     | 
|COCH-ARM / FISHERS |     P=0.252      P=0.490N     P=0.490N     P=0.515     |P=0.591N     P=0.684N     P=0.691N     P=0.684N     | 
|ORDER RESTRICTED   |     P=0.130      (e)          (e)          (e)         |P=0.734      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Karyomegaly                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    0/49 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      1/46.70      1/44.19     |0/43.57      0/45.35      0/42.00      3/43.56      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.1%         2.3%        |0.0%         0.0%         0.0%         6.9%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          672          618         |---          ---          ---          688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.223      (e)          P=0.519      P=0.500     |P=0.012 *    (e)          (e)          P=0.120      | 
|POLY 3             |     P=0.228      (e)          P=0.512      P=0.501     |P=0.011 *    (e)          (e)          P=0.118      | 
|POLY 1.5           |     P=0.233      (e)          P=0.511      P=0.504     |P=0.011 *    (e)          (e)          P=0.118      | 
|POLY 6             |     P=0.221      (e)          P=0.515      P=0.498     |P=0.011 *    (e)          (e)          P=0.119      | 
|LOGISTIC REGRESSION|     P=0.295      (e)          P=0.494      P=0.565     |P=0.011 *    (e)          (e)          P=0.120      | 
|COCH-ARM / FISHERS |     P=0.240      (e)          P=0.510      P=0.510     |P=0.012 *    (e)          (e)          P=0.125      | 
|ORDER RESTRICTED   |     P=0.252      (e)          (e)          (e)         |P=0.008 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |4/49 (8%)    3/50 (6%)    6/49 (12%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/43.91      0/47.28      0/46.48      3/43.80     |4/44.34      3/46.68      6/42.98      4/44.38      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         0.0%         6.9%        |9.0%         6.4%         14.0%        9.0%         | 
|TERMINAL (d)       |     2/38 (5%)    0/41 (0%)    0/41 (0%)    3/33 (9%)   |2/36 (6%)    0/35 (0%)    2/31 (7%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |576          492          602          618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.197      P=0.222N     P=0.222N     P=0.435     |P=0.473      P=0.492N     P=0.332      P=0.626N     | 
|POLY 3             |     P=0.242      P=0.221N     P=0.225N     P=0.499     |P=0.467      P=0.472N     P=0.350      P=0.643N     | 
|POLY 1.5           |     P=0.246      P=0.224N     P=0.226N     P=0.506     |P=0.469      P=0.480N     P=0.347      P=0.643      | 
|POLY 6             |     P=0.237      P=0.216N     P=0.223N     P=0.489     |P=0.469      P=0.462N     P=0.353      P=0.637N     | 
|LOGISTIC REGRESSION|     P=0.197      (e)          (e)          P=0.435     |P=0.525      P=0.497N     P=0.372      P=0.610N     | 
|COCH-ARM / FISHERS |     P=0.254      P=0.237N     P=0.237N     P=0.520     |P=0.492      P=0.489N     P=0.370      P=0.631N     | 
|ORDER RESTRICTED   |     P=0.096      (e)          (e)          (e)         |P=0.435      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      0/46.48      0/43.80     |0/43.57      1/45.42      1/42.00      2/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         2.4%         4.6%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    1/31 (3%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          713          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.148      P=0.521      P=0.470      P=0.232      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.149      P=0.508      P=0.493      P=0.236      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.150      P=0.506      P=0.492      P=0.237      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.149      P=0.512      P=0.493      P=0.237      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.147      P=0.509      P=0.470      P=0.232      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.156      P=0.505      P=0.500      P=0.253      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.116      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Kupffer Cell                                                                                                              | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |3/49 (6%)    4/50 (8%)    4/49 (8%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |     2/44.16      0/47.28      1/46.48      0/43.80     |3/44.25      4/45.43      4/42.39      7/43.95      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         2.2%         0.0%        |6.8%         8.8%         9.4%         15.9%        | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |1/36 (3%)    2/35 (6%)    3/31 (10%)   5/35 (14%)   | 
|FIRST INCIDENCE    |     663          ---          729 (T)      ---         |591          713          618          618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.203N     P=0.216N     P=0.469N     P=0.261N    |P=0.104      P=0.509      P=0.451      P=0.162      | 
|POLY 3             |     P=0.190N     P=0.222N     P=0.482N     P=0.239N    |P=0.098      P=0.514      P=0.477      P=0.154      | 
|POLY 1.5           |     P=0.187N     P=0.225N     P=0.483N     P=0.235N    |P=0.100      P=0.512      P=0.477      P=0.155      | 
|POLY 6             |     P=0.194N     P=0.218N     P=0.481N     P=0.245N    |P=0.097      P=0.519      P=0.475      P=0.154      | 
|LOGISTIC REGRESSION|     P=0.183N     P=0.234N     P=0.485N     P=0.227N    |P=0.101      P=0.512      P=0.497      P=0.162      | 
|COCH-ARM / FISHERS |     P=0.182N     P=0.237N     P=0.485N     P=0.237N    |P=0.110      P=0.511      P=0.500      P=0.167      | 
|ORDER RESTRICTED   |     P=0.075N     (e)          (e)          (e)         |P=0.119      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   11/50 (22%)  7/50 (14%)   8/50 (16%)  |5/50 (10%)   8/50 (16%)   3/49 (6%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     6/45.23      11/47.28     7/47.45      8/44.39     |5/44.57      8/45.97      3/41.40      5/43.80      | 
|POLY-3 PERCENT (g) |     13.3%        23.3%        14.8%        18.0%       |11.2%        17.4%        7.3%         11.4%        | 
|TERMINAL (d)       |     4/38 (11%)   11/41 (27%)  4/41 (10%)   6/33 (18%)  |2/36 (6%)    5/35 (14%)   2/30 (7%)    3/35 (9%)    | 
|FIRST INCIDENCE    |     623          729 (T)      570          640         |588          552          711          667          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.380      P=0.189      P=0.557      P=0.310     |P=0.419N     P=0.286      P=0.416N     P=0.623N     | 
|POLY 3             |     P=0.479      P=0.165      P=0.537      P=0.371     |P=0.415N     P=0.295      P=0.397N     P=0.620      | 
|POLY 1.5           |     P=0.488      P=0.157      P=0.524      P=0.379     |P=0.411N     P=0.290      P=0.392N     P=0.621      | 
|POLY 6             |     P=0.464      P=0.174      P=0.550      P=0.360     |P=0.420N     P=0.301      P=0.408N     P=0.619      | 
|LOGISTIC REGRESSION|     P=0.481      P=0.179      P=0.483      P=0.377     |P=0.406N     P=0.276      P=0.380N     P=0.628      | 
|COCH-ARM / FISHERS |     P=0.500      P=0.143      P=0.500      P=0.387     |P=0.394N     P=0.277      P=0.369N     P=0.630N     | 
|ORDER RESTRICTED   |     P=0.400      (e)          (e)          (e)         |P=0.374N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.60      0/47.28      0/46.48      1/43.83     |2/44.25      0/45.35      0/41.33      0/43.40      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         2.3%        |4.5%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |1/36 (3%)    0/35 (0%)    0/30 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          721         |524          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.567      P=0.485N     P=0.485N     P=0.732     |P=0.123N     P=0.245N     P=0.267N     P=0.248N     | 
|POLY 3             |     P=0.584      P=0.488N     P=0.492N     P=0.757     |P=0.117N     P=0.232N     P=0.252N     P=0.241N     | 
|POLY 1.5           |     P=0.588      P=0.493N     P=0.494N     P=0.758     |P=0.117N     P=0.234N     P=0.251N     P=0.241N     | 
|POLY 6             |     P=0.579      P=0.483N     P=0.489N     P=0.754     |P=0.119N     P=0.229N     P=0.255N     P=0.241N     | 
|LOGISTIC REGRESSION|     P=0.580      (e)          (e)          P=0.750     |P=0.105N     P=0.270N     P=0.218N     P=0.223N     | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.116N     P=0.247N     P=0.253N     P=0.247N     | 
|ORDER RESTRICTED   |     P=0.390      (e)          (e)          (e)         |P=0.031N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/50 (6%)    4/50 (8%)    5/50 (10%)  |5/50 (10%)   8/50 (16%)   6/49 (12%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     5/45.85      3/47.31      4/46.48      5/44.39     |5/43.63      8/46.03      6/41.79      4/43.40      | 
|POLY-3 PERCENT (g) |     10.9%        6.3%         8.6%         11.3%       |11.5%        17.4%        14.4%        9.2%         | 
|TERMINAL (d)       |     2/38 (5%)    2/41 (5%)    4/41 (10%)   3/33 (9%)   |5/36 (14%)   5/35 (14%)   4/30 (13%)   4/35 (11%)   | 
|FIRST INCIDENCE    |     561          722          729 (T)      640         |729 (T)      552          602          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.407      P=0.322N     P=0.461N     P=0.578     |P=0.345N     P=0.272      P=0.391      P=0.518N     | 
|POLY 3             |     P=0.455      P=0.339N     P=0.491N     P=0.610     |P=0.329N     P=0.311      P=0.470      P=0.503N     | 
|POLY 1.5           |     P=0.467      P=0.345N     P=0.492N     P=0.619     |P=0.328N     P=0.298      P=0.467      P=0.505N     | 
|POLY 6             |     P=0.440      P=0.333N     P=0.494N     P=0.597     |P=0.328N     P=0.329      P=0.472      P=0.500N     | 
|LOGISTIC REGRESSION|     P=0.487      P=0.396N     P=0.527N     P=0.625N    |P=0.329N     P=0.302      P=0.459      P=0.518N     | 
|COCH-ARM / FISHERS |     P=0.483      P=0.357N     P=0.500N     P=0.630N    |P=0.315N     P=0.277      P=0.486      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.523      (e)          (e)          (e)         |P=0.371N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    5/50 (10%)   7/50 (14%)   6/50 (12%)  |10/50 (20%)  8/50 (16%)   3/49 (6%)    9/50 (18%)   | 
|POLY-3 RATE (b)    |     4/44.60      5/47.28      7/46.48      6/44.12     |10/44.05     8/45.35      3/41.33      9/43.40      | 
|POLY-3 PERCENT (g) |     9.0%         10.6%        15.1%        13.6%       |22.7%        17.6%        7.3%         20.7%        | 
|TERMINAL (d)       |     4/38 (11%)   5/41 (12%)   7/41 (17%)   5/33 (15%)  |9/36 (25%)   8/35 (23%)   3/30 (10%)   9/35 (26%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      640         |606          729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.200      P=0.548      P=0.305      P=0.294     |P=0.453N     P=0.417N     P=0.068N     P=0.525N     | 
|POLY 3             |     P=0.277      P=0.536      P=0.285      P=0.362     |P=0.447N     P=0.370N     P=0.044N*    P=0.515N     | 
|POLY 1.5           |     P=0.285      P=0.522      P=0.277      P=0.366     |P=0.442N     P=0.379N     P=0.044N*    P=0.513N     | 
|POLY 6             |     P=0.264      P=0.554      P=0.293      P=0.356     |P=0.453N     P=0.358N     P=0.045N*    P=0.516N     | 
|LOGISTIC REGRESSION|     P=0.238      P=0.548      P=0.305      P=0.344     |P=0.446N     P=0.336N     P=0.045N*    P=0.496N     | 
|COCH-ARM / FISHERS |     P=0.296      P=0.500      P=0.262      P=0.370     |P=0.423N     P=0.398N     P=0.039N*    P=0.500N     | 
|ORDER RESTRICTED   |     P=0.354      (e)          (e)          (e)         |P=0.225N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   5/50 (10%)   9/50 (18%)   10/50 (20%) |1/50 (2%)    1/50 (2%)    3/49 (6%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     8/45.49      5/47.28      9/47.94      10/45.14    |1/43.63      1/45.35      3/41.37      5/44.24      | 
|POLY-3 PERCENT (g) |     17.6%        10.6%        18.8%        22.2%       |2.3%         2.2%         7.3%         11.3%        | 
|TERMINAL (d)       |     5/38 (13%)   5/41 (12%)   5/41 (12%)   4/33 (12%)  |1/36 (3%)    1/35 (3%)    2/30 (7%)    3/35 (9%)    | 
|FIRST INCIDENCE    |     603          729 (T)      543          595         |729 (T)      729 (T)      719          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.154      P=0.233N     P=0.560      P=0.335     |P=0.031 *    P=0.756      P=0.255      P=0.105      | 
|POLY 3             |     P=0.202      P=0.251N     P=0.547      P=0.390     |P=0.030 *    P=0.752N     P=0.286      P=0.104      | 
|POLY 1.5           |     P=0.208      P=0.260N     P=0.531      P=0.393     |P=0.030 *    P=0.755N     P=0.287      P=0.102      | 
|POLY 6             |     P=0.195      P=0.242N     P=0.564      P=0.384     |P=0.030 *    P=0.748N     P=0.284      P=0.108      | 
|LOGISTIC REGRESSION|     P=0.223      P=0.256N     P=0.465      P=0.395     |P=0.030 *    P=0.756      P=0.276      P=0.103      | 
|COCH-ARM / FISHERS |     P=0.217      P=0.277N     P=0.500      P=0.398     |P=0.031 *    P=0.753N     P=0.301      P=0.102      | 
|ORDER RESTRICTED   |     P=0.247      (e)          (e)          (e)         |P=0.047 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Metaplasia Osseous                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/49 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.60      2/47.28      0/46.48      0/43.80     |0/43.63      1/45.35      2/41.40      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         0.0%        |0.0%         2.2%         4.8%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    2/41 (5%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    1/35 (3%)    1/30 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          729 (T)      712          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.434N     P=0.255      (e)          (e)         |P=0.627N     P=0.494      P=0.217      (e)          | 
|POLY 3             |     P=0.396N     P=0.250      (e)          (e)         |P=0.621N     P=0.508      P=0.225      (e)          | 
|POLY 1.5           |     P=0.399N     P=0.245      (e)          (e)         |P=0.621N     P=0.505      P=0.226      (e)          | 
|POLY 6             |     P=0.394N     P=0.257      (e)          (e)         |P=0.619N     P=0.511      P=0.225      (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.255      (e)          (e)         |P=0.623N     P=0.494      P=0.223      (e)          | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |P=0.616N     P=0.500      P=0.242      (e)          | 
|ORDER RESTRICTED   |     P=0.262N     (e)          (e)          (e)         |P=0.315      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    4/50 (8%)    1/49 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |1/44.25      4/46.59      1/41.37      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.3%         8.6%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    1/35 (3%)    0/30 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |524          513          719          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.179N     P=0.185      P=0.747      P=0.508N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.168N     P=0.195      P=0.746      P=0.504N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.168N     P=0.189      P=0.747      P=0.503N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.168N     P=0.203      P=0.743      P=0.504N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.146N     P=0.114      P=0.749N     P=0.453N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.164N     P=0.181      P=0.747      P=0.500N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.117N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    1/50 (2%)    5/50 (10%)  |2/50 (4%)    2/50 (4%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/44.60      3/47.28      1/46.48      5/43.80     |2/43.63      2/46.01      1/41.33      2/43.40      | 
|POLY-3 PERCENT (g) |     4.5%         6.4%         2.2%         11.4%       |4.6%         4.4%         2.4%         4.6%         | 
|TERMINAL (d)       |     2/38 (5%)    3/41 (7%)    1/41 (2%)    5/33 (15%)  |2/36 (6%)    1/35 (3%)    1/30 (3%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      513          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.106      P=0.535      P=0.473N     P=0.162     |P=0.592N     P=0.686      P=0.564N     P=0.685      | 
|POLY 3             |     P=0.152      P=0.526      P=0.486N     P=0.208     |P=0.588N     P=0.675N     P=0.519N     P=0.692      | 
|POLY 1.5           |     P=0.155      P=0.516      P=0.490N     P=0.212     |P=0.586N     P=0.682N     P=0.518N     P=0.691      | 
|POLY 6             |     P=0.147      P=0.539      P=0.481N     P=0.202     |P=0.590N     P=0.666N     P=0.521N     P=0.694N     | 
|LOGISTIC REGRESSION|     P=0.106      P=0.535      P=0.473N     P=0.162     |P=0.584N     P=0.682      P=0.564N     P=0.685      | 
|COCH-ARM / FISHERS |     P=0.160      P=0.500      P=0.500N     P=0.218     |P=0.578N     P=0.691N     P=0.508N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.130      (e)          (e)          (e)         |P=0.626N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/49 (29%)  14/48 (29%)  16/45 (36%)  16/49 (33%) |12/46 (26%)  7/46 (15%)   7/49 (14%)   10/49 (20%)  | 
|POLY-3 RATE (b)    |     14/43.97     14/46.81     16/42.99     16/43.61    |12/41.35     7/44.35      7/41.37      10/42.40     | 
|POLY-3 PERCENT (g) |     31.8%        29.9%        37.2%        36.7%       |29.0%        15.8%        16.9%        23.6%        | 
|TERMINAL (d)       |     14/38 (37%)  13/41 (32%)  13/37 (35%)  13/33 (39%) |10/34 (29%)  2/34 (6%)    7/31 (23%)   10/34 (29%)  | 
|FIRST INCIDENCE    |     729 (T)      668          562          595         |591          461          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.162      P=0.490N     P=0.393      P=0.255     |P=0.466N     P=0.156N     P=0.205N     P=0.402N     | 
|POLY 3             |     P=0.290      P=0.511N     P=0.381      P=0.400     |P=0.449N     P=0.111N     P=0.146N     P=0.376N     | 
|POLY 1.5           |     P=0.309      P=0.550N     P=0.354      P=0.406     |P=0.426N     P=0.124N     P=0.139N     P=0.364N     | 
|POLY 6             |     P=0.267      P=0.466N     P=0.414      P=0.389     |P=0.478N     P=0.099N     P=0.159N     P=0.392N     | 
|LOGISTIC REGRESSION|     P=0.247      P=0.440N     P=0.361      P=0.336     |P=0.414N     P=0.166N     P=0.141N     P=0.358N     | 
|COCH-ARM / FISHERS |     P=0.336      P=0.563      P=0.307      P=0.413     |P=0.381N     P=0.151N     P=0.119N     P=0.340N     | 
|ORDER RESTRICTED   |     P=0.434      (e)          (e)          (e)         |P=0.196N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   10/48 (21%)  9/45 (20%)   9/49 (18%)  |18/46 (39%)  16/46 (35%)  18/49 (37%)  15/49 (31%)  | 
|POLY-3 RATE (b)    |     7/44.77      10/46.73     9/43.21      9/44.27     |18/40.93     16/42.85     18/41.73     15/43.32     | 
|POLY-3 PERCENT (g) |     15.6%        21.4%        20.8%        20.3%       |44.0%        37.3%        43.1%        34.6%        | 
|TERMINAL (d)       |     5/38 (13%)   8/41 (20%)   6/37 (16%)   5/33 (15%)  |16/34 (47%)  14/34 (41%)  15/31 (48%)  13/34 (38%)  | 
|FIRST INCIDENCE    |     561          698          558          570         |639          714          662          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.296      P=0.368      P=0.397      P=0.323     |P=0.349N     P=0.401N     P=0.457      P=0.331N     | 
|POLY 3             |     P=0.386      P=0.331      P=0.362      P=0.382     |P=0.266N     P=0.345N     P=0.558N     P=0.254N     | 
|POLY 1.5           |     P=0.396      P=0.313      P=0.349      P=0.387     |P=0.261N     P=0.368N     P=0.547N     P=0.257N     | 
|POLY 6             |     P=0.372      P=0.350      P=0.375      P=0.375     |P=0.274N     P=0.324N     P=0.578N     P=0.253N     | 
|LOGISTIC REGRESSION|     P=0.422      P=0.305      P=0.295      P=0.394     |P=0.300N     P=0.284N     P=0.588N     P=0.272N     | 
|COCH-ARM / FISHERS |     P=0.411      P=0.281      P=0.322      P=0.393     |P=0.240N     P=0.415N     P=0.488N     P=0.256N     | 
|ORDER RESTRICTED   |     P=0.425      (e)          (e)          (e)         |P=0.298N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/47 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |1/47 (2%)    1/49 (2%)    0/49 (0%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     2/43.78      1/47.40      0/46.48      1/44.06     |1/42.08      1/44.92      0/41.33      2/43.16      | 
|POLY-3 PERCENT (g) |     4.6%         2.1%         0.0%         2.3%        |2.4%         2.2%         0.0%         4.6%         | 
|TERMINAL (d)       |     1/38 (3%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/34 (0%)    1/35 (3%)    0/30 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     638          698          ---          657         |576          729 (T)      ---          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.391N     P=0.464N     P=0.224N     P=0.522N    |P=0.360      P=0.756      P=0.518N     P=0.492      | 
|POLY 3             |     P=0.358N     P=0.472N     P=0.224N     P=0.498N    |P=0.367      P=0.746N     P=0.504N     P=0.509      | 
|POLY 1.5           |     P=0.356N     P=0.475N     P=0.224N     P=0.491N    |P=0.368      P=0.749N     P=0.502N     P=0.508      | 
|POLY 6             |     P=0.361N     P=0.468N     P=0.225N     P=0.507N    |P=0.366      P=0.742N     P=0.506N     P=0.510      | 
|LOGISTIC REGRESSION|     P=0.318N     P=0.487N     P=0.228N     P=0.449N    |P=0.409      P=0.761      P=0.433N     P=0.614      | 
|COCH-ARM / FISHERS |     P=0.352N     P=0.477N     P=0.232N     P=0.477N    |P=0.375      P=0.742N     P=0.490N     P=0.516      | 
|ORDER RESTRICTED   |     P=0.218N     (e)          (e)          (e)         |P=0.278      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/47 (4%)    0/49 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/43.45      0/47.28      0/46.48      0/43.80     |2/42.04      0/44.92      0/41.33      1/42.63      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.8%         0.0%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |1/34 (3%)    0/35 (0%)    0/30 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |591          ---          ---          667          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.463N     P=0.239N     P=0.259N     P=0.494N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.461N     P=0.222N     P=0.241N     P=0.495N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.458N     P=0.225N     P=0.239N     P=0.494N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.465N     P=0.218N     P=0.243N     P=0.494N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.440N     P=0.238N     P=0.215N     P=0.467N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.452N     P=0.237N     P=0.237N     P=0.484N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.127N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/47 (4%)    0/50 (0%)    4/50 (8%)    1/50 (2%)   |2/47 (4%)    2/49 (4%)    1/49 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     2/43.45      0/47.28      4/46.48      1/43.80     |2/41.57      2/44.92      1/41.33      2/42.40      | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         8.6%         2.3%        |4.8%         4.5%         2.4%         4.7%         | 
|TERMINAL (d)       |     2/38 (5%)    0/41 (0%)    4/41 (10%)   1/33 (3%)   |2/34 (6%)    2/35 (6%)    1/30 (3%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.572      P=0.222N     P=0.372      P=0.549N    |P=0.586N     P=0.685N     P=0.544N     P=0.696      | 
|POLY 3             |     P=0.592N     P=0.219N     P=0.369      P=0.497N    |P=0.578N     P=0.666N     P=0.502N     P=0.687N     | 
|POLY 1.5           |     P=0.579N     P=0.221N     P=0.368      P=0.490N    |P=0.576N     P=0.672N     P=0.501N     P=0.687N     | 
|POLY 6             |     P=0.589      P=0.215N     P=0.369      P=0.506N    |P=0.580N     P=0.657N     P=0.503N     P=0.685N     | 
|LOGISTIC REGRESSION|     P=0.572      (e)          P=0.372      P=0.549N    |P=0.586N     P=0.685N     P=0.544N     P=0.696      | 
|COCH-ARM / FISHERS |     P=0.558N     P=0.232N     P=0.369      P=0.477N    |P=0.565N     P=0.676N     P=0.484N     P=0.676N     | 
|ORDER RESTRICTED   |     P=0.338      (e)          (e)          (e)         |P=0.607N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/47 (9%)    6/50 (12%)   2/50 (4%)    4/50 (8%)   |4/47 (9%)    2/49 (4%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     4/43.70      6/47.54      2/46.48      4/44.19     |4/42.04      2/44.92      0/41.33      1/42.40      | 
|POLY-3 PERCENT (g) |     9.2%         12.6%        4.3%         9.1%        |9.5%         4.5%         0.0%         2.4%         | 
|TERMINAL (d)       |     3/38 (8%)    4/41 (10%)   2/41 (5%)    2/33 (6%)   |3/34 (9%)    2/35 (6%)    0/30 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     663          668          729 (T)      640         |591          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.511N     P=0.431      P=0.301N     P=0.587     |P=0.092N     P=0.328N     P=0.079N     P=0.183N     | 
|POLY 3             |     P=0.428N     P=0.424      P=0.309N     P=0.637N    |P=0.085N     P=0.307N     P=0.062N     P=0.175N     | 
|POLY 1.5           |     P=0.418N     P=0.417      P=0.309N     P=0.627N    |P=0.084N     P=0.312N     P=0.061N     P=0.174N     | 
|POLY 6             |     P=0.441N     P=0.434      P=0.310N     P=0.637     |P=0.086N     P=0.298N     P=0.063N     P=0.175N     | 
|LOGISTIC REGRESSION|     P=0.431N     P=0.418      P=0.306N     P=0.630N    |P=0.086N     P=0.309N     P=0.061N     P=0.172N     | 
|COCH-ARM / FISHERS |     P=0.400N     P=0.410      P=0.310N     P=0.607N    |P=0.080N     P=0.319N     P=0.054N     P=0.168N     | 
|ORDER RESTRICTED   |     P=0.382N     (e)          (e)          (e)         |P=0.037N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/47 (23%)  6/50 (12%)   6/50 (12%)   9/50 (18%)  |10/47 (21%)  8/49 (16%)   11/49 (22%)  6/49 (12%)   | 
|POLY-3 RATE (b)    |     11/43.45     6/47.35      6/46.72      9/44.60     |10/42.00     8/45.72      11/41.37     6/42.70      | 
|POLY-3 PERCENT (g) |     25.3%        12.7%        12.8%        20.2%       |23.8%        17.5%        26.6%        14.1%        | 
|TERMINAL (d)       |     11/38 (29%)  5/41 (12%)   5/41 (12%)   6/33 (18%)  |9/34 (27%)   5/35 (14%)   10/30 (33%)  5/34 (15%)   | 
|FIRST INCIDENCE    |     729 (T)      713          667          570         |606          561          719          646          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.529      P=0.105N     P=0.105N     P=0.523N    |P=0.235N     P=0.369N     P=0.379      P=0.201N     | 
|POLY 3             |     P=0.436N     P=0.100N     P=0.105N     P=0.374N    |P=0.223N     P=0.321N     P=0.484      P=0.191N     | 
|POLY 1.5           |     P=0.425N     P=0.106N     P=0.108N     P=0.364N    |P=0.217N     P=0.339N     P=0.491      P=0.192N     | 
|POLY 6             |     P=0.452N     P=0.092N     P=0.102N     P=0.387N    |P=0.228N     P=0.295N     P=0.475      P=0.187N     | 
|LOGISTIC REGRESSION|     P=0.478N     P=0.085N     P=0.106N     P=0.410N    |P=0.218N     P=0.336N     P=0.489      P=0.187N     | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.113N     P=0.113N     P=0.342N    |P=0.192N     P=0.360N     P=0.543      P=0.181N     | 
|ORDER RESTRICTED   |     P=0.167N     (e)          (e)          (e)         |P=0.209N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mesenteric                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/47 (2%)    2/49 (4%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.45      0/47.28      0/46.48      0/43.80     |1/41.57      2/44.92      0/41.33      0/42.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.4%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |1/34 (3%)    2/35 (6%)    0/30 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.195N     P=0.510      P=0.525N     P=0.500N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.186N     P=0.527      P=0.501N     P=0.496N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.186N     P=0.521      P=0.501N     P=0.496N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.185N     P=0.536      P=0.502N     P=0.495N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.195N     P=0.510      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.182N     P=0.516      P=0.490N     P=0.490N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.179N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Mediastinal                                                                                                          | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/3 (0%)     0/0 (0%)     0/1 (0%)     0/3 (0%)    |1/7 (14%)    1/5 (20%)    2/11 (18%)   0/9 (0%)     | 
|POLY-3 RATE (b)    |     0/1.27       0/0.00       0/1.00       0/1.86      |1/5.75       1/4.24       2/9.85       0/6.72       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |17.4%        23.6%        20.3%        0.0%         | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/1 (0%)     0/0 (0%)    |1/5 (20%)    1/3 (33%)    1/6 (17%)    0/5 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      661          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.326N     P=0.653      P=0.543      P=0.500N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.279N     P=0.697      P=0.689      P=0.468N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.277N     P=0.693      P=0.679      P=0.466N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.286N     P=0.701      P=0.696      P=0.474N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.272N     P=0.653      P=0.688      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.247N     P=0.682      P=0.674      P=0.438N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.277N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |5/50 (10%)   11/50 (22%)  8/50 (16%)   10/50 (20%)  | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |5/44.17      11/46.31     8/43.14      10/45.34     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |11.3%        23.8%        18.6%        22.1%        | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |3/36 (8%)    6/35 (17%)   5/31 (16%)   4/35 (11%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |591          561          618          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.200      P=0.102      P=0.221      P=0.144      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.211      P=0.100      P=0.259      P=0.140      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.203      P=0.094      P=0.258      P=0.134      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.225      P=0.109      P=0.259      P=0.150      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.198      P=0.092      P=0.259      P=0.133      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.204      P=0.086      P=0.277      P=0.131      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.150      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/9 (11%)    0/10 (0%)    0/10 (0%)    2/8 (25%)   |0/30 (0%)    0/32 (0%)    0/27 (0%)    1/24 (4%)    | 
|POLY-3 RATE (b)    |     1/7.50       0/9.21       0/9.01       2/7.15      |0/25.00      0/29.43      0/23.16      1/22.04      | 
|POLY-3 PERCENT (g) |     13.3%        0.0%         0.0%         28.0%       |0.0%         0.0%         0.0%         4.5%         | 
|TERMINAL (d)       |     1/5 (20%)    0/9 (0%)     0/7 (0%)     0/4 (0%)    |0/18 (0%)    0/21 (0%)    0/14 (0%)    1/17 (6%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          570         |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.208      P=0.383N     P=0.433N     P=0.474     |P=0.185      (e)          (e)          P=0.489      | 
|POLY 3             |     P=0.191      P=0.459N     P=0.463N     P=0.482     |P=0.171      (e)          (e)          P=0.475      | 
|POLY 1.5           |     P=0.195      P=0.470N     P=0.470N     P=0.470     |P=0.168      (e)          (e)          P=0.467      | 
|POLY 6             |     P=0.181      P=0.437N     P=0.452N     P=0.503     |P=0.173      (e)          (e)          P=0.484      | 
|LOGISTIC REGRESSION|     P=0.215      (e)          (e)          P=0.484     |(e)          (e)          (e)          P=0.489      | 
|COCH-ARM / FISHERS |     P=0.201      P=0.474N     P=0.474N     P=0.453     |P=0.164      (e)          (e)          P=0.444      | 
|ORDER RESTRICTED   |     P=0.094      (e)          (e)          (e)         |P=0.100      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/9 (33%)    8/10 (80%)   6/10 (60%)   5/8 (63%)   |21/30 (70%)  24/32 (75%)  20/27 (74%)  16/24 (67%)  | 
|POLY-3 RATE (b)    |     3/7.83       8/10.00      6/9.24       5/7.15      |21/28.75     24/30.98     20/24.79     16/23.36     | 
|POLY-3 PERCENT (g) |     38.3%        80.0%        64.9%        69.9%       |73.1%        77.5%        80.7%        68.5%        | 
|TERMINAL (d)       |     2/5 (40%)    7/9 (78%)    5/7 (71%)    3/4 (75%)   |11/18 (61%)  16/21 (76%)  12/14 (86%)  11/17 (65%)  | 
|FIRST INCIDENCE    |     638          431          668          570         |524          552          618          540          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.190      P=0.278      P=0.370      P=0.247     |P=0.202N     P=0.534      P=0.409      P=0.241N     | 
|POLY 3             |     P=0.291      P=0.081      P=0.268      P=0.232     |P=0.393N     P=0.462      P=0.366      P=0.478N     | 
|POLY 1.5           |     P=0.298      P=0.061      P=0.256      P=0.236     |P=0.396N     P=0.454      P=0.420      P=0.486N     | 
|POLY 6             |     P=0.280      P=0.124      P=0.291      P=0.231     |P=0.408N     P=0.464      P=0.290      P=0.483N     | 
|LOGISTIC REGRESSION|     P=0.278      P=0.057      P=0.327      P=0.208     |P=0.343N     P=0.476      P=0.520      P=0.531N     | 
|COCH-ARM / FISHERS |     P=0.307      P=0.055      P=0.242      P=0.238     |P=0.416N     P=0.438      P=0.482      P=0.511N     | 
|ORDER RESTRICTED   |     P=0.144      (e)          (e)          (e)         |P=0.387N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.60      1/47.28      0/46.48      2/44.61     |0/43.63      0/45.35      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    1/41 (2%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          465         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.336      P=0.745N     P=0.485N     P=0.478     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.364      P=0.747N     P=0.492N     P=0.500     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.365      P=0.752N     P=0.494N     P=0.501     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.360      P=0.741N     P=0.489N     P=0.498     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.389      P=0.745N     (e)          P=0.510     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.366      P=0.753N     P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.266      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    5/50 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.60      2/47.28      1/46.48      5/45.36     |0/43.63      0/45.35      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     2.2%         4.2%         2.2%         11.0%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    2/41 (5%)    1/41 (2%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      465         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.036 *    P=0.527      P=0.745N     P=0.099     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.047 *    P=0.520      P=0.751N     P=0.105     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.047 *    P=0.512      P=0.754N     P=0.104     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.046 *    P=0.530      P=0.748N     P=0.106     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.055      P=0.527      P=0.745N     P=0.106     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.047 *    P=0.500      P=0.753N     P=0.102     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.038 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/45 (7%)    2/45 (4%)    4/47 (9%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |3/39.57      2/41.78      4/40.91      3/44.12      | 
|POLY-3 PERCENT (g) |                                                        |7.6%         4.8%         9.8%         6.8%         | 
|TERMINAL (d)       |                                                        |3/32 (9%)    1/34 (3%)    2/30 (7%)    2/35 (6%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      714          542          475          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.513      P=0.471N     P=0.472      P=0.629N     | 
|POLY 3             |                                                        |P=0.548      P=0.475N     P=0.518      P=0.612N     | 
|POLY 1.5           |                                                        |P=0.547      P=0.486N     P=0.511      P=0.616N     | 
|POLY 6             |                                                        |P=0.550      P=0.459N     P=0.529      P=0.604N     | 
|LOGISTIC REGRESSION|                                                        |P=0.558      P=0.444N     P=0.510      P=0.614N     | 
|COCH-ARM / FISHERS |                                                        |P=0.560      P=0.500N     P=0.525      P=0.610N     | 
|ORDER RESTRICTED   |                                                        |P=0.560      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |10/45 (22%)  15/45 (33%)  14/47 (30%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |                                                        |10/39.57     15/42.11     14/41.83     13/43.65     | 
|POLY-3 PERCENT (g) |                                                        |25.3%        35.6%        33.5%        29.8%        | 
|TERMINAL (d)       |                                                        |10/32 (31%)  13/34 (38%)  10/30 (33%)  11/35 (31%)  | 
|FIRST INCIDENCE    |                                                        |729 (T)      674          486          688          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.434      P=0.222      P=0.188      P=0.396      | 
|POLY 3             |                                                        |P=0.478      P=0.218      P=0.284      P=0.415      | 
|POLY 1.5           |                                                        |P=0.478      P=0.196      P=0.265      P=0.409      | 
|POLY 6             |                                                        |P=0.488      P=0.255      P=0.310      P=0.433      | 
|LOGISTIC REGRESSION|                                                        |P=0.468      P=0.269      P=0.251      P=0.430      | 
|COCH-ARM / FISHERS |                                                        |P=0.512      P=0.173      P=0.279      P=0.426      | 
|ORDER RESTRICTED   |                                                        |P=0.359      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/45 (7%)    1/45 (2%)    1/47 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/40.53      1/41.72      1/40.25      0/43.40      | 
|POLY-3 PERCENT (g) |                                                        |7.4%         2.4%         2.5%         0.0%         | 
|TERMINAL (d)       |                                                        |1/32 (3%)    1/34 (3%)    1/30 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |                                                        |524          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.073N     P=0.291N     P=0.327N     P=0.118N     | 
|POLY 3             |                                                        |P=0.067N     P=0.295N     P=0.307N     P=0.106N     | 
|POLY 1.5           |                                                        |P=0.066N     P=0.300N     P=0.306N     P=0.105N     | 
|POLY 6             |                                                        |P=0.068N     P=0.287N     P=0.308N     P=0.106N     | 
|LOGISTIC REGRESSION|                                                        |P=0.058N     P=0.344N     P=0.268N     P=0.078N     | 
|COCH-ARM / FISHERS |                                                        |P=0.062N     P=0.308N     P=0.292N     P=0.103N     | 
|ORDER RESTRICTED   |                                                        |P=0.031N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Follicle                                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/45 (2%)    4/45 (9%)    4/47 (9%)    9/50 (18%)   | 
|POLY-3 RATE (b)    |                                                        |1/39.57      4/41.72      4/40.25      9/43.79      | 
|POLY-3 PERCENT (g) |                                                        |2.5%         9.6%         9.9%         20.6%        | 
|TERMINAL (d)       |                                                        |1/32 (3%)    4/34 (12%)   4/30 (13%)   8/35 (23%)   | 
|FIRST INCIDENCE    |                                                        |729 (T)      729 (T)      729 (T)      618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.007 **   P=0.197      P=0.159      P=0.014 *    | 
|POLY 3             |                                                        |P=0.007 **   P=0.194      P=0.183      P=0.012 *    | 
|POLY 1.5           |                                                        |P=0.007 **   P=0.187      P=0.181      P=0.012 *    | 
|POLY 6             |                                                        |P=0.007 **   P=0.205      P=0.185      P=0.013 *    | 
|LOGISTIC REGRESSION|                                                        |P=0.007 **   P=0.197      P=0.159      P=0.014 *    | 
|COCH-ARM / FISHERS |                                                        |P=0.009 **   P=0.180      P=0.194      P=0.012 *    | 
|ORDER RESTRICTED   |                                                        |P=0.005 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary: Granulosa Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/45 (0%)    0/45 (0%)    3/47 (6%)    7/50 (14%)   | 
|POLY-3 RATE (b)    |                                                        |0/39.57      0/41.72      3/40.25      7/44.00      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         7.5%         15.9%        | 
|TERMINAL (d)       |                                                        |0/32 (0%)    0/34 (0%)    3/30 (10%)   6/35 (17%)   | 
|FIRST INCIDENCE    |                                                        |---          ---          729 (T)      535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P<0.001 **   (e)          P=0.109      P=0.012 *    | 
|POLY 3             |                                                        |P<0.001 **   (e)          P=0.121      P=0.011 *    | 
|POLY 1.5           |                                                        |P<0.001 **   (e)          P=0.120      P=0.011 *    | 
|POLY 6             |                                                        |P<0.001 **   (e)          P=0.122      P=0.011 *    | 
|LOGISTIC REGRESSION|                                                        |P<0.001 **   (e)          P=0.109      P=0.013 *    | 
|COCH-ARM / FISHERS |                                                        |P<0.001 **   (e)          P=0.129      P=0.009 **   | 
|ORDER RESTRICTED   |                                                        |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/46 (4%)    1/47 (2%)    0/49 (0%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      0/46.48      0/43.80     |2/42.28      1/44.26      0/42.00      1/42.44      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.7%         2.3%         0.0%         2.4%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |2/36 (6%)    1/35 (3%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.378N     P=0.510N     P=0.272N     P=0.510N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.365N     P=0.484N     P=0.238N     P=0.499N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.363N     P=0.488N     P=0.236N     P=0.497N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.368N     P=0.478N     P=0.241N     P=0.498N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.378N     P=0.510N     (e)          P=0.510N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.354N     P=0.492N     P=0.232N     P=0.484N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.224N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas                                                                                                                         | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/46 (0%)    1/47 (2%)    1/49 (2%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      0/46.48      2/44.54     |0/42.28      1/44.26      1/42.00      0/42.44      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.5%        |0.0%         2.3%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    1/35 (3%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          465         |---          729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.040 *    (e)          (e)          P=0.224     |P=0.601N     P=0.494      P=0.470      (e)          | 
|POLY 3             |     P=0.045 *    (e)          (e)          P=0.240     |P=0.598N     P=0.509      P=0.499      (e)          | 
|POLY 1.5           |     P=0.046 *    (e)          (e)          P=0.242     |P=0.596N     P=0.507      P=0.501      (e)          | 
|POLY 6             |     P=0.044 *    (e)          (e)          P=0.237     |P=0.598N     P=0.513      P=0.496      (e)          | 
|LOGISTIC REGRESSION|     P=0.087      (e)          (e)          P=0.317     |(e)          P=0.494      P=0.470      (e)          | 
|COCH-ARM / FISHERS |     P=0.048 *    (e)          (e)          P=0.258     |P=0.586N     P=0.505      P=0.516      (e)          | 
|ORDER RESTRICTED   |     P=0.031 *    (e)          (e)          (e)         |P=0.403N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Parathyroid Gland                                                                                                                | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/46 (0%)    1/48 (2%)    2/47 (4%)    1/49 (2%)   |1/45 (2%)    1/47 (2%)    2/48 (4%)    2/47 (4%)    | 
|POLY-3 RATE (b)    |     0/42.34      1/45.51      2/43.48      1/43.58     |1/40.35      1/42.62      2/41.18      2/40.40      | 
|POLY-3 PERCENT (g) |     0.0%         2.2%         4.6%         2.3%        |2.5%         2.4%         4.9%         5.0%         | 
|TERMINAL (d)       |     0/37 (0%)    1/40 (3%)    2/38 (5%)    0/33 (0%)   |1/33 (3%)    0/34 (0%)    1/30 (3%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      595         |729 (T)      727          683          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.337      P=0.516      P=0.244      P=0.509     |P=0.326      P=0.757N     P=0.478      P=0.489      | 
|POLY 3             |     P=0.362      P=0.514      P=0.243      P=0.506     |P=0.329      P=0.749N     P=0.507      P=0.500      | 
|POLY 1.5           |     P=0.369      P=0.512      P=0.243      P=0.508     |P=0.333      P=0.750N     P=0.507      P=0.503      | 
|POLY 6             |     P=0.353      P=0.518      P=0.243      P=0.503     |P=0.326      P=0.744N     P=0.509      P=0.501      | 
|LOGISTIC REGRESSION|     P=0.392      P=0.516      P=0.244      P=0.593     |P=0.327      P=0.741N     P=0.506      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.382      P=0.511      P=0.253      P=0.516     |P=0.349      P=0.742N     P=0.524      P=0.516      | 
|ORDER RESTRICTED   |     P=0.231      (e)          (e)          (e)         |P=0.435      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Peripheral Nerve                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/0 (0%)     1/1 (100%)   0/2 (0%)     0/1 (0%)    |0/0 (0%)     0/0 (0%)     1/2 (50%)    2/2 (100%)   | 
|POLY-3 RATE (b)    |     0/0.00       1/1.00       0/1.35       0/0.06      |0/0.00       0/0.00       1/1.30       2/2.00       | 
|POLY-3 PERCENT (g) |     0.0%         100.0%       0.0%         0.0%        |0.0%         0.0%         77.1%        100.0%       | 
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          604          ---          ---         |---          ---          662          667          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.570N     (e)          (e)          (e)         |P=0.237      (e)          P=0.500      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.613N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.396N     (e)          (e)          (e)         |P=0.500      (e)          P=1.000      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/47 (0%)    0/45 (0%)    0/49 (0%)   |1/46 (2%)    2/45 (4%)    2/48 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/42.10      0/44.28      0/42.54      0/42.80     |1/41.52      2/41.26      2/40.71      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.4%         4.9%         4.9%         0.0%         | 
|TERMINAL (d)       |     0/37 (0%)    0/38 (0%)    0/38 (0%)    0/32 (0%)   |1/35 (3%)    2/32 (6%)    2/30 (7%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.296N     P=0.469      P=0.446      P=0.500N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.286N     P=0.498      P=0.493      P=0.491N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.283N     P=0.495      P=0.496      P=0.490N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.289N     P=0.502      P=0.490      P=0.492N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.296N     P=0.469      P=0.446      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.270N     P=0.492      P=0.516      P=0.479N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.213N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/47 (2%)    1/47 (2%)    2/45 (4%)    5/49 (10%)  |0/46 (0%)    0/45 (0%)    0/48 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/42.10      1/44.35      2/42.76      5/42.80     |0/41.52      0/41.26      0/40.71      1/43.40      | 
|POLY-3 PERCENT (g) |     2.4%         2.3%         4.7%         11.7%       |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/37 (3%)    0/38 (0%)    1/38 (3%)    5/32 (16%)  |0/35 (0%)    0/32 (0%)    0/30 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      713          673          729 (T)     |---          ---          ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.017 *    P=0.741N     P=0.515      P=0.072     |P=0.207      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.029 *    P=0.749N     P=0.505      P=0.104     |P=0.205      (e)          (e)          P=0.509      | 
|POLY 1.5           |     P=0.030 *    P=0.753N     P=0.498      P=0.108     |P=0.207      (e)          (e)          P=0.510      | 
|POLY 6             |     P=0.027 *    P=0.744N     P=0.513      P=0.099     |P=0.204      (e)          (e)          P=0.508      | 
|LOGISTIC REGRESSION|     P=0.025 *    P=0.749N     P=0.495      P=0.072     |(e)          (e)          (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.033 *    P=0.753N     P=0.484      P=0.112     |P=0.211      (e)          (e)          P=0.521      | 
|ORDER RESTRICTED   |     P=0.036 *    (e)          (e)          (e)         |P=0.129      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/47 (0%)    0/47 (0%)    0/45 (0%)    0/49 (0%)   |3/46 (7%)    3/45 (7%)    3/48 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/42.10      0/44.28      0/42.54      0/42.80     |3/41.52      3/41.26      3/40.71      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |7.2%         7.3%         7.4%         2.3%         | 
|TERMINAL (d)       |     0/37 (0%)    0/38 (0%)    0/38 (0%)    0/32 (0%)   |3/35 (9%)    3/32 (9%)    3/30 (10%)   1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |729 (T)      729 (T)      729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.220N     P=0.622      P=0.591      P=0.305N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.208N     P=0.660      P=0.654      P=0.289N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.204N     P=0.656      P=0.657      P=0.286N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.211N     P=0.660N     P=0.649      P=0.290N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.220N     P=0.622      P=0.591      P=0.305N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.190N     P=0.651      P=0.641N     P=0.278N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.263N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     22/50 (44%)  26/50 (52%)  15/50 (30%)  29/50 (58%) |                                                    | 
|POLY-3 RATE (b)    |     22/47.74     26/47.94     15/47.22     29/46.39    |                                                    | 
|POLY-3 PERCENT (g) |     46.1%        54.2%        31.8%        62.5%       |                                                    | 
|TERMINAL (d)       |     14/38 (37%)  23/41 (56%)  13/41 (32%)  20/33 (61%) |                                                    | 
|FIRST INCIDENCE    |     484          577          570          465         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.068      P=0.416      P=0.085N     P=0.071     |                                                    | 
|POLY 3             |     P=0.124      P=0.276      P=0.109N     P=0.078     |                                                    | 
|POLY 1.5           |     P=0.141      P=0.280      P=0.105N     P=0.092     |                                                    | 
|POLY 6             |     P=0.102      P=0.269      P=0.121N     P=0.060     |                                                    | 
|LOGISTIC REGRESSION|     P=0.155      P=0.289      P=0.113N     P=0.112     |                                                    | 
|COCH-ARM / FISHERS |     P=0.169      P=0.274      P=0.107N     P=0.115     |                                                    | 
|ORDER RESTRICTED   |     P=0.047 *    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     28/50 (56%)  27/50 (54%)  18/50 (36%)  21/50 (42%) |                                                    | 
|POLY-3 RATE (b)    |     28/47.20     27/48.03     18/47.45     21/45.80    |                                                    | 
|POLY-3 PERCENT (g) |     59.3%        56.2%        37.9%        45.9%       |                                                    | 
|TERMINAL (d)       |     22/38 (58%)  22/41 (54%)  15/41 (37%)  14/33 (42%) |                                                    | 
|FIRST INCIDENCE    |     484          577          562          465         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.191N     P=0.350N     P=0.024N*    P=0.279N    |                                                    | 
|POLY 3             |     P=0.068N     P=0.460N     P=0.027N*    P=0.133N    |                                                    | 
|POLY 1.5           |     P=0.062N     P=0.473N     P=0.028N*    P=0.123N    |                                                    | 
|POLY 6             |     P=0.080N     P=0.441N     P=0.026N*    P=0.151N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.065N     P=0.433N     P=0.030N*    P=0.120N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.057N     P=0.500N     P=0.035N*    P=0.115N    |                                                    | 
|ORDER RESTRICTED   |     P=0.064N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    4/50 (8%)    3/50 (6%)    5/50 (10%)  |                                                    | 
|POLY-3 RATE (b)    |     1/44.60      4/47.79      3/46.48      5/44.36     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         8.4%         6.5%         11.3%       |                                                    | 
|TERMINAL (d)       |     1/38 (3%)    3/41 (7%)    3/41 (7%)    3/33 (9%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      574          729 (T)      570         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.078      P=0.206      P=0.333      P=0.085     |                                                    | 
|POLY 3             |     P=0.108      P=0.201      P=0.320      P=0.100     |                                                    | 
|POLY 1.5           |     P=0.110      P=0.192      P=0.315      P=0.101     |                                                    | 
|POLY 6             |     P=0.104      P=0.212      P=0.325      P=0.098     |                                                    | 
|LOGISTIC REGRESSION|     P=0.110      P=0.171      P=0.333      P=0.101     |                                                    | 
|COCH-ARM / FISHERS |     P=0.113      P=0.181      P=0.309      P=0.102     |                                                    | 
|ORDER RESTRICTED   |     P=0.076      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/48 (0%)    0/47 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      1/46.48      2/43.83     |0/42.53      0/43.74      0/41.37      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.2%         4.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    1/41 (2%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          729 (T)      721         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.052      (e)          P=0.515      P=0.212     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.065      (e)          P=0.508      P=0.233     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.067      (e)          P=0.506      P=0.235     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.063      (e)          P=0.511      P=0.230     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.056      (e)          P=0.515      P=0.224     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.070      (e)          P=0.500      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.072      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 44      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Salivary Glands                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   3/50 (6%)    6/50 (12%)   4/50 (8%)   |16/48 (33%)  21/47 (45%)  15/49 (31%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     7/44.60      3/47.28      6/46.48      4/43.80     |16/43.42     21/44.04     15/42.58     18/43.95     | 
|POLY-3 PERCENT (g) |     15.7%        6.4%         12.9%        9.1%        |36.9%        47.7%        35.2%        41.0%        | 
|TERMINAL (d)       |     7/38 (18%)   3/41 (7%)    6/41 (15%)   4/33 (12%)  |13/36 (36%)  18/35 (51%)  12/31 (39%)  16/35 (46%)  | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |630          682          486          618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.411N     P=0.128N     P=0.441N     P=0.345N    |P=0.470      P=0.198      P=0.508      P=0.390      | 
|POLY 3             |     P=0.342N     P=0.135N     P=0.468N     P=0.271N    |P=0.532      P=0.208      P=0.527N     P=0.431      | 
|POLY 1.5           |     P=0.332N     P=0.144N     P=0.479N     P=0.267N    |P=0.530N     P=0.199      P=0.519N     P=0.444      | 
|POLY 6             |     P=0.359N     P=0.124N     P=0.457N     P=0.278N    |P=0.507      P=0.214      P=0.547N     P=0.413      | 
|LOGISTIC REGRESSION|     P=0.411N     P=0.128N     P=0.441N     P=0.345N    |P=0.523      P=0.244      P=0.535N     P=0.439      | 
|COCH-ARM / FISHERS |     P=0.316N     P=0.159N     P=0.500N     P=0.262N    |P=0.481N     P=0.178      P=0.472N     P=0.474      | 
|ORDER RESTRICTED   |     P=0.263N     (e)          (e)          (e)         |P=0.522      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     0/44.60      1/47.28      0/46.48      2/43.80     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         4.6%        |                                                    | 
|TERMINAL (d)       |     0/38 (0%)    1/41 (2%)    0/41 (0%)    2/33 (6%)   |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          729 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.110      P=0.515      (e)          P=0.208     |                                                    | 
|POLY 3             |     P=0.137      P=0.512      (e)          P=0.233     |                                                    | 
|POLY 1.5           |     P=0.138      P=0.507      (e)          P=0.235     |                                                    | 
|POLY 6             |     P=0.135      P=0.517      (e)          P=0.230     |                                                    | 
|LOGISTIC REGRESSION|     (e)          P=0.515      (e)          P=0.208     |                                                    | 
|COCH-ARM / FISHERS |     P=0.140      P=0.500      (e)          P=0.247     |                                                    | 
|ORDER RESTRICTED   |     P=0.072      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 45      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Seminal Vesicle                                                                                                                  | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     3/44.60      0/47.28      1/46.48      0/43.80     |                                                    | 
|POLY-3 PERCENT (g) |     6.7%         0.0%         2.2%         0.0%        |                                                    | 
|TERMINAL (d)       |     3/38 (8%)    0/41 (0%)    1/41 (2%)    0/33 (0%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.096N     P=0.108N     P=0.278N     P=0.147N    |                                                    | 
|POLY 3             |     P=0.090N     P=0.109N     P=0.291N     P=0.122N    |                                                    | 
|POLY 1.5           |     P=0.088N     P=0.113N     P=0.296N     P=0.120N    |                                                    | 
|POLY 6             |     P=0.093N     P=0.104N     P=0.286N     P=0.124N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.096N     (e)          P=0.278N     (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.086N     P=0.121N     P=0.309N     P=0.121N    |                                                    | 
|ORDER RESTRICTED   |     P=0.022N*    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)   |0/48 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      3/44.59     |0/42.09      1/45.35      0/42.33      1/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         6.7%        |0.0%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/35 (0%)    1/35 (3%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          618         |---          729 (T)      ---          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    (e)          (e)          P=0.117     |P=0.404      P=0.500      (e)          P=0.500      | 
|POLY 3             |     P=0.010 *    (e)          (e)          P=0.118     |P=0.408      P=0.515      (e)          P=0.506      | 
|POLY 1.5           |     P=0.011 *    (e)          (e)          P=0.119     |P=0.408      P=0.513      (e)          P=0.506      | 
|POLY 6             |     P=0.010 *    (e)          (e)          P=0.118     |P=0.409      P=0.518      (e)          P=0.506      | 
|LOGISTIC REGRESSION|     P=0.016 *    (e)          (e)          P=0.123     |(e)          P=0.500      (e)          P=0.500      | 
|COCH-ARM / FISHERS |     P=0.012 *    (e)          (e)          P=0.121     |P=0.411      P=0.510      (e)          P=0.510      | 
|ORDER RESTRICTED   |     P=0.008 **   (e)          (e)          (e)         |P=0.257      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 46      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/48 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.60      0/47.28      0/46.48      0/43.80     |0/42.09      0/45.35      0/42.33      0/43.40      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/35 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.122N     P=0.222N     P=0.222N     P=0.270N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.116N     P=0.224N     P=0.228N     P=0.241N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.115N     P=0.229N     P=0.231N     P=0.239N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.117N     P=0.218N     P=0.225N     P=0.244N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.122N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.031N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Subcutaneous Tissue                                                                                                        | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/48 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.60      0/47.28      0/46.48      0/43.80     |0/42.09      0/45.35      1/43.00      2/44.99      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.3%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/35 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          503          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.069      (e)          P=0.496      P=0.235      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.074      (e)          P=0.504      P=0.252      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.073      (e)          P=0.504      P=0.250      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.074      (e)          P=0.504      P=0.254      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.085      (e)          P=0.589      P=0.308      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.073      (e)          P=0.510      P=0.258      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.084      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 47      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hematopoietic Cell Proliferation                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     21/48 (44%)  17/50 (34%)  18/50 (36%)  21/50 (42%) |39/49 (80%)  39/48 (81%)  35/49 (71%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     21/46.42     17/48.74     18/49.41     21/47.89    |39/47.38     39/46.92     35/44.21     39/47.88     | 
|POLY-3 PERCENT (g) |     45.2%        34.9%        36.4%        43.9%       |82.3%        83.1%        79.2%        81.5%        | 
|TERMINAL (d)       |     14/38 (37%)  11/41 (27%)  10/41 (24%)  7/33 (21%)  |31/36 (86%)  31/35 (89%)  26/31 (84%)  31/35 (89%)  | 
|FIRST INCIDENCE    |     561          574          558          535         |440          461          602          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309      P=0.202N     P=0.274N     P=0.451     |P=0.472      P=0.529      P=0.545      P=0.513      | 
|POLY 3             |     P=0.488      P=0.206N     P=0.252N     P=0.528N    |P=0.471N     P=0.569      P=0.451N     P=0.565N     | 
|POLY 1.5           |     P=0.488      P=0.211N     P=0.264N     P=0.529N    |P=0.446N     P=0.549      P=0.415N     P=0.547N     | 
|POLY 6             |     P=0.493      P=0.199N     P=0.239N     P=0.521N    |P=0.504N     P=0.592      P=0.480N     P=0.592N     | 
|LOGISTIC REGRESSION|     P=0.467N     P=0.245N     P=0.314N     P=0.454N    |P=0.498N     P=0.558      P=0.342N     P=0.546N     | 
|COCH-ARM / FISHERS |     P=0.504      P=0.217N     P=0.282N     P=0.512N    |P=0.394N     P=0.520      P=0.241N     P=0.521N     | 
|ORDER RESTRICTED   |     P=0.396N     (e)          (e)          (e)         |P=0.589N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/48 (17%)   9/50 (18%)   10/50 (20%)  8/50 (16%)  |11/49 (22%)  10/48 (21%)  5/49 (10%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     8/43.91      9/47.28      10/46.48     8/43.80     |11/43.57     10/44.61     5/42.25      9/43.70      | 
|POLY-3 PERCENT (g) |     18.2%        19.0%        21.5%        18.3%       |25.2%        22.4%        11.8%        20.6%        | 
|TERMINAL (d)       |     8/38 (21%)   9/41 (22%)   10/41 (24%)  8/33 (24%)  |11/36 (31%)  10/35 (29%)  4/31 (13%)   8/35 (23%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |729 (T)      729 (T)      662          646          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.411      P=0.570      P=0.466      P=0.486     |P=0.322N     P=0.530N     P=0.139N     P=0.422N     | 
|POLY 3             |     P=0.538      P=0.567      P=0.449      P=0.606     |P=0.298N     P=0.475N     P=0.092N     P=0.397N     | 
|POLY 1.5           |     P=0.540N     P=0.553      P=0.443      P=0.597N    |P=0.296N     P=0.496N     P=0.095N     P=0.400N     | 
|POLY 6             |     P=0.510      P=0.586      P=0.456      P=0.589     |P=0.297N     P=0.447N     P=0.088N     P=0.386N     | 
|LOGISTIC REGRESSION|     P=0.411      P=0.570      P=0.466      P=0.486     |P=0.315N     P=0.530N     P=0.095N     P=0.395N     | 
|COCH-ARM / FISHERS |     P=0.507N     P=0.537      P=0.435      P=0.572N    |P=0.274N     P=0.521N     P=0.085N     P=0.382N     | 
|ORDER RESTRICTED   |     P=0.649      (e)          (e)          (e)         |P=0.233N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 48      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    3/50 (6%)    1/50 (2%)    1/50 (2%)   |28/49 (57%)  30/48 (63%)  28/49 (57%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     0/43.91      3/48.22      1/46.48      1/44.06     |28/45.87     30/45.09     28/43.82     27/45.83     | 
|POLY-3 PERCENT (g) |     0.0%         6.2%         2.2%         2.3%        |61.1%        66.5%        63.9%        58.9%        | 
|TERMINAL (d)       |     0/38 (0%)    1/41 (2%)    1/41 (2%)    0/33 (0%)   |22/36 (61%)  24/35 (69%)  20/31 (65%)  21/35 (60%)  | 
|FIRST INCIDENCE    |     ---          574          729 (T)      657         |524          673          602          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.567      P=0.138      P=0.515      P=0.490     |P=0.478N     P=0.401      P=0.336      P=0.546N     | 
|POLY 3             |     P=0.586      P=0.136      P=0.511      P=0.501     |P=0.387N     P=0.370      P=0.475      P=0.502N     | 
|POLY 1.5           |     P=0.591      P=0.132      P=0.510      P=0.503     |P=0.383N     P=0.368      P=0.479      P=0.498N     | 
|POLY 6             |     P=0.579      P=0.143      P=0.513      P=0.498     |P=0.387N     P=0.381      P=0.479      P=0.501N     | 
|LOGISTIC REGRESSION|     P=0.566N     P=0.107      P=0.515      P=0.534     |P=0.425N     P=0.480      P=0.499      P=0.502N     | 
|COCH-ARM / FISHERS |     P=0.602      P=0.129      P=0.510      P=0.510     |P=0.332N     P=0.371      P=0.581N     P=0.455N     | 
|ORDER RESTRICTED   |     P=0.245      (e)          (e)          (e)         |P=0.488N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen: Lymphoid Follicle                                                                                                        | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    0/50 (0%)    1/50 (2%)    3/50 (6%)   |1/49 (2%)    2/48 (4%)    1/49 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.24      0/47.28      1/46.70      3/45.11     |1/44.08      2/44.66      1/42.07      2/44.16      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.1%         6.7%        |2.3%         4.5%         2.4%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     638          ---          672          570         |576          719          712          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.092      P=0.482N     P=0.742N     P=0.312     |P=0.429      P=0.496      P=0.747      P=0.489      | 
|POLY 3             |     P=0.096      P=0.487N     P=0.749N     P=0.312     |P=0.443      P=0.505      P=0.750      P=0.501      | 
|POLY 1.5           |     P=0.097      P=0.489N     P=0.750N     P=0.314     |P=0.444      P=0.499      P=0.751      P=0.501      | 
|POLY 6             |     P=0.093      P=0.484N     P=0.747N     P=0.309     |P=0.442      P=0.512      P=0.750      P=0.502      | 
|LOGISTIC REGRESSION|     P=0.177      P=0.502N     P=0.750      P=0.422     |P=0.481      P=0.468      P=0.748N     P=0.611      | 
|COCH-ARM / FISHERS |     P=0.101      P=0.490N     P=0.742N     P=0.324     |P=0.455      P=0.492      P=0.753N     P=0.508      | 
|ORDER RESTRICTED   |     P=0.083      (e)          (e)          (e)         |P=0.443      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 49      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     2/44.53      0/47.28      0/46.48      0/43.80     |0/43.57      0/45.35      0/42.33      0/43.12      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/38 (5%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.122N     P=0.222N     P=0.222N     P=0.270N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.113N     P=0.224N     P=0.228N     P=0.241N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.112N     P=0.228N     P=0.230N     P=0.238N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.114N     P=0.218N     P=0.225N     P=0.244N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.122N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.113N     P=0.242N     P=0.242N     P=0.242N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.031N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Diverticulum                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |2/49 (4%)    1/50 (2%)    1/50 (2%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     1/44.53      1/47.28      0/46.48      2/43.80     |2/43.57      1/45.35      1/42.33      2/43.88      | 
|POLY-3 PERCENT (g) |     2.3%         2.1%         0.0%         4.6%        |4.6%         2.2%         2.4%         4.6%         | 
|TERMINAL (d)       |     1/38 (3%)    1/41 (2%)    0/41 (0%)    2/33 (6%)   |2/36 (6%)    1/35 (3%)    1/31 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          729 (T)     |729 (T)      729 (T)      729 (T)      455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.318      P=0.745N     P=0.485N     P=0.451     |P=0.543      P=0.510N     P=0.552N     P=0.686      | 
|POLY 3             |     P=0.361      P=0.747N     P=0.491N     P=0.494     |P=0.551      P=0.486N     P=0.510N     P=0.692N     | 
|POLY 1.5           |     P=0.365      P=0.751N     P=0.493N     P=0.499     |P=0.549      P=0.490N     P=0.509N     P=0.693      | 
|POLY 6             |     P=0.356      P=0.741N     P=0.489N     P=0.489     |P=0.553      P=0.480N     P=0.512N     P=0.687N     | 
|LOGISTIC REGRESSION|     P=0.318      P=0.745N     (e)          P=0.451     |P=0.556      P=0.510N     P=0.552N     P=0.677N     | 
|COCH-ARM / FISHERS |     P=0.371      P=0.747N     P=0.495N     P=0.508     |P=0.554      P=0.492N     P=0.492N     P=0.691N     | 
|ORDER RESTRICTED   |     P=0.259      (e)          (e)          (e)         |P=0.543N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 50      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Edema                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    0/50 (0%)    3/50 (6%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/44.53      0/47.28      0/46.48      0/43.80     |0/43.57      0/45.35      3/42.37      0/43.12      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         7.1%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    2/31 (7%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          720          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.529      (e)          P=0.101      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.532      (e)          P=0.113      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.531      (e)          P=0.114      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.535      (e)          P=0.113      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.531      (e)          P=0.111      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.538      (e)          P=0.125      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.157      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    2/50 (4%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     0/44.53      1/47.28      0/46.48      0/43.80     |0/43.57      1/45.39      2/43.10      2/44.04      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         0.0%         0.0%        |0.0%         2.2%         4.6%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    1/41 (2%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          719          542          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.593N     P=0.515      (e)          (e)         |P=0.156      P=0.505      P=0.235      P=0.240      | 
|POLY 3             |     P=0.560N     P=0.512      (e)          (e)         |P=0.160      P=0.508      P=0.235      P=0.239      | 
|POLY 1.5           |     P=0.563N     P=0.508      (e)          (e)         |P=0.157      P=0.506      P=0.234      P=0.237      | 
|POLY 6             |     P=0.557N     P=0.517      (e)          (e)         |P=0.164      P=0.512      P=0.236      P=0.243      | 
|LOGISTIC REGRESSION|     (e)          P=0.515      (e)          (e)         |P=0.176      P=0.511      P=0.273      P=0.297      | 
|COCH-ARM / FISHERS |     P=0.565N     P=0.505      (e)          (e)         |P=0.158      P=0.505      P=0.253      P=0.247      | 
|ORDER RESTRICTED   |     P=0.394N     (e)          (e)          (e)         |P=0.153      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 51      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    4/50 (8%)    2/50 (4%)   |0/49 (0%)    0/50 (0%)    2/50 (4%)    2/49 (4%)    | 
|POLY-3 RATE (b)    |     2/44.97      2/47.71      4/48.04      2/44.08     |0/43.57      0/45.35      2/42.40      2/43.12      | 
|POLY-3 PERCENT (g) |     4.5%         4.2%         8.3%         4.5%        |0.0%         0.0%         4.7%         4.6%         | 
|TERMINAL (d)       |     1/38 (3%)    1/41 (2%)    1/41 (2%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    1/31 (3%)    2/35 (6%)    | 
|FIRST INCIDENCE    |     603          604          543          652         |---          ---          712          729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.509      P=0.669N     P=0.362      P=0.665     |P=0.084      (e)          P=0.220      P=0.232      | 
|POLY 3             |     P=0.518      P=0.672N     P=0.368      P=0.687     |P=0.081      (e)          P=0.231      P=0.235      | 
|POLY 1.5           |     P=0.530      P=0.679N     P=0.359      P=0.692     |P=0.081      (e)          P=0.232      P=0.234      | 
|POLY 6             |     P=0.502      P=0.663N     P=0.379      P=0.681     |P=0.081      (e)          P=0.230      P=0.236      | 
|LOGISTIC REGRESSION|     P=0.501N     P=0.677      P=0.251      P=0.673N    |P=0.082      (e)          P=0.229      P=0.232      | 
|COCH-ARM / FISHERS |     P=0.551      P=0.684N     P=0.349      P=0.684N    |P=0.084      (e)          P=0.253      P=0.247      | 
|ORDER RESTRICTED   |     P=0.515      (e)          (e)          (e)         |P=0.111      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |2/49 (4%)    0/50 (0%)    3/50 (6%)    3/49 (6%)    | 
|POLY-3 RATE (b)    |     1/44.97      1/47.28      2/47.43      1/44.08     |2/44.16      0/45.35      3/42.39      3/44.66      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         4.2%         2.3%        |4.5%         0.0%         7.1%         6.7%         | 
|TERMINAL (d)       |     0/38 (0%)    1/41 (2%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     603          729 (T)      570          652         |576          ---          720          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.578      P=0.747N     P=0.513      P=0.758     |P=0.224      P=0.238N     P=0.458      P=0.489      | 
|POLY 3             |     P=0.572      P=0.749N     P=0.519      P=0.756     |P=0.231      P=0.231N     P=0.481      P=0.505      | 
|POLY 1.5           |     P=0.581      P=0.752N     P=0.514      P=0.759     |P=0.228      P=0.232N     P=0.486      P=0.500      | 
|POLY 6             |     P=0.561      P=0.745N     P=0.525      P=0.753     |P=0.235      P=0.229N     P=0.476      P=0.512      | 
|LOGISTIC REGRESSION|     P=0.525N     P=0.753      P=0.395      P=0.716N    |P=0.251      P=0.235N     P=0.499      P=0.612      | 
|COCH-ARM / FISHERS |     P=0.596      P=0.747N     P=0.508      P=0.747N    |P=0.230      P=0.242N     P=0.510      P=0.500      | 
|ORDER RESTRICTED   |     P=0.588      (e)          (e)          (e)         |P=0.229      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 52      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach: Epithelium                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/49 (6%)    7/50 (14%)   2/50 (4%)    4/50 (8%)   |3/49 (6%)    4/50 (8%)    9/50 (18%)   6/49 (12%)   | 
|POLY-3 RATE (b)    |     3/45.51      7/48.35      2/47.07      4/45.62     |3/44.90      4/45.94      9/44.15      6/44.64      | 
|POLY-3 PERCENT (g) |     6.6%         14.5%        4.3%         8.8%        |6.7%         8.7%         20.4%        13.4%        | 
|TERMINAL (d)       |     1/38 (3%)    4/41 (10%)   1/41 (2%)    1/33 (3%)   |0/36 (0%)    2/35 (6%)    3/31 (10%)   3/35 (9%)    | 
|FIRST INCIDENCE    |     562          574          543          288         |440          561          542          455          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.548N     P=0.201      P=0.477N     P=0.480     |P=0.157      P=0.502      P=0.060      P=0.242      | 
|POLY 3             |     P=0.501N     P=0.184      P=0.485N     P=0.501     |P=0.150      P=0.512      P=0.055      P=0.239      | 
|POLY 1.5           |     P=0.496N     P=0.176      P=0.487N     P=0.506     |P=0.148      P=0.510      P=0.055      P=0.236      | 
|POLY 6             |     P=0.509N     P=0.196      P=0.482N     P=0.494     |P=0.154      P=0.518      P=0.056      P=0.243      | 
|LOGISTIC REGRESSION|     P=0.321N     P=0.124      P=0.574N     P=0.654N    |P=0.179      P=0.502      P=0.083      P=0.305      | 
|COCH-ARM / FISHERS |     P=0.490N     P=0.167      P=0.490N     P=0.511     |P=0.157      P=0.511      P=0.065      P=0.243      | 
|ORDER RESTRICTED   |     P=0.382N     (e)          (e)          (e)         |P=0.105      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/48 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)   |0/49 (0%)    0/48 (0%)    0/50 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     1/43.91      2/47.35      1/46.48      0/43.80     |0/43.57      0/44.61      0/42.33      0/43.12      | 
|POLY-3 PERCENT (g) |     2.3%         4.2%         2.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/38 (3%)    1/41 (2%)    1/41 (2%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      713          729 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.276N     P=0.534      P=0.745N     P=0.528N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.250N     P=0.526      P=0.748N     P=0.501N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.247N     P=0.521      P=0.749N     P=0.497N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.255N     P=0.534      P=0.746N     P=0.505N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.260N     P=0.536      P=0.745N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.239N     P=0.515      P=0.742N     P=0.490N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.241N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 53      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    1/48 (2%)    2/50 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      0/46.48      0/43.80     |0/43.57      1/44.70      2/43.03      0/43.12      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/41 (0%)    0/33 (0%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          706          503          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.631N     P=0.520      P=0.225      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.620N     P=0.505      P=0.234      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.621N     P=0.501      P=0.234      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.618N     P=0.511      P=0.235      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.595N     P=0.499      P=0.273      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.614N     P=0.495      P=0.253      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.322      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   3/50 (6%)    4/50 (8%)   |                                                    | 
|POLY-3 RATE (b)    |     1/44.93      5/47.78      3/46.69      4/44.42     |                                                    | 
|POLY-3 PERCENT (g) |     2.2%         10.5%        6.4%         9.0%        |                                                    | 
|TERMINAL (d)       |     0/38 (0%)    3/41 (7%)    2/41 (5%)    1/33 (3%)   |                                                    | 
|FIRST INCIDENCE    |     638          604          673          640         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.217      P=0.130      P=0.334      P=0.169     |                                                    | 
|POLY 3             |     P=0.256      P=0.116      P=0.319      P=0.175     |                                                    | 
|POLY 1.5           |     P=0.260      P=0.111      P=0.315      P=0.177     |                                                    | 
|POLY 6             |     P=0.250      P=0.124      P=0.323      P=0.172     |                                                    | 
|LOGISTIC REGRESSION|     P=0.271      P=0.090      P=0.293      P=0.182     |                                                    | 
|COCH-ARM / FISHERS |     P=0.264      P=0.102      P=0.309      P=0.181     |                                                    | 
|ORDER RESTRICTED   |     P=0.169      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 54      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/43 (26%)  13/43 (30%)  4/40 (10%)   13/44 (30%) |5/48 (10%)   7/44 (16%)   5/48 (10%)   9/48 (19%)   | 
|POLY-3 RATE (b)    |     11/41.26     13/42.85     4/38.58      13/42.11    |5/43.97      7/41.56      5/42.42      9/45.96      | 
|POLY-3 PERCENT (g) |     26.7%        30.3%        10.4%        30.9%       |11.4%        16.9%        11.8%        19.6%        | 
|TERMINAL (d)       |     6/34 (18%)   8/36 (22%)   1/33 (3%)    3/30 (10%)  |0/35 (0%)    3/34 (9%)    0/30 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     561          574          543          465         |524          568          503          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.402      P=0.479      P=0.055N     P=0.361     |P=0.185      P=0.405      P=0.610      P=0.213      | 
|POLY 3             |     P=0.493      P=0.448      P=0.055N     P=0.428     |P=0.213      P=0.339      P=0.608      P=0.217      | 
|POLY 1.5           |     P=0.495      P=0.431      P=0.056N     P=0.425     |P=0.206      P=0.333      P=0.609      P=0.210      | 
|POLY 6             |     P=0.492      P=0.466      P=0.056N     P=0.434     |P=0.218      P=0.347      P=0.605      P=0.225      | 
|LOGISTIC REGRESSION|     P=0.428N     P=0.217      P=0.077N     P=0.512     |P=0.232      P=0.247      P=0.570N     P=0.191      | 
|COCH-ARM / FISHERS |     P=0.505      P=0.405      P=0.058N     P=0.431     |P=0.194      P=0.318      P=0.630N     P=0.193      | 
|ORDER RESTRICTED   |     P=0.307      (e)          (e)          (e)         |P=0.211      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/43 (2%)    3/43 (7%)    4/40 (10%)   4/44 (9%)   |3/48 (6%)    0/44 (0%)    1/48 (2%)    1/48 (2%)    | 
|POLY-3 RATE (b)    |     1/39.03      3/41.31      4/37.25      4/38.62     |3/42.41      0/40.66      1/40.71      1/42.10      | 
|POLY-3 PERCENT (g) |     2.6%         7.3%         10.7%        10.4%       |7.1%         0.0%         2.5%         2.4%         | 
|TERMINAL (d)       |     1/34 (3%)    3/36 (8%)    4/33 (12%)   4/30 (13%)  |2/35 (6%)    0/34 (0%)    1/30 (3%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |630          ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.106      P=0.325      P=0.169      P=0.142     |P=0.302N     P=0.122N     P=0.353N     P=0.304N     | 
|POLY 3             |     P=0.145      P=0.326      P=0.163      P=0.174     |P=0.301N     P=0.126N     P=0.320N     P=0.307N     | 
|POLY 1.5           |     P=0.151      P=0.317      P=0.161      P=0.178     |P=0.298N     P=0.129N     P=0.318N     P=0.308N     | 
|POLY 6             |     P=0.136      P=0.336      P=0.166      P=0.169     |P=0.305N     P=0.122N     P=0.323N     P=0.307N     | 
|LOGISTIC REGRESSION|     P=0.106      P=0.325      P=0.169      P=0.142     |P=0.294N     P=0.134N     P=0.315N     P=0.305N     | 
|COCH-ARM / FISHERS |     P=0.164      P=0.308      P=0.158      P=0.187     |P=0.289N     P=0.138N     P=0.308N     P=0.308N     | 
|ORDER RESTRICTED   |     P=0.146      (e)          (e)          (e)         |P=0.105N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 55      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/43 (5%)    1/43 (2%)    0/40 (0%)    0/44 (0%)   |5/48 (10%)   3/44 (7%)    4/48 (8%)    2/48 (4%)    | 
|POLY-3 RATE (b)    |     2/39.03      1/41.31      0/37.25      0/38.62     |5/42.05      3/40.66      4/40.71      2/42.49      | 
|POLY-3 PERCENT (g) |     5.1%         2.4%         0.0%         0.0%        |11.9%        7.4%         9.8%         4.7%         | 
|TERMINAL (d)       |     2/34 (6%)    1/36 (3%)    0/33 (0%)    0/30 (0%)   |5/35 (14%)   3/34 (9%)    4/30 (13%)   1/35 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |729 (T)      729 (T)      729 (T)      618          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.113N     P=0.480N     P=0.245N     P=0.266N    |P=0.204N     P=0.371N     P=0.598N     P=0.215N     | 
|POLY 3             |     P=0.104N     P=0.480N     P=0.247N     P=0.239N    |P=0.195N     P=0.374N     P=0.520N     P=0.211N     | 
|POLY 1.5           |     P=0.103N     P=0.488N     P=0.250N     P=0.237N    |P=0.196N     P=0.386N     P=0.520N     P=0.215N     | 
|POLY 6             |     P=0.105N     P=0.470N     P=0.244N     P=0.242N    |P=0.193N     P=0.361N     P=0.523N     P=0.204N     | 
|LOGISTIC REGRESSION|     P=0.113N     P=0.480N     (e)          (e)         |P=0.196N     P=0.371N     P=0.598N     P=0.214N     | 
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.265N     P=0.241N    |P=0.189N     P=0.407N     P=0.500N     P=0.218N     | 
|ORDER RESTRICTED   |     P=0.075N     (e)          (e)          (e)         |P=0.180N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland                                                                                                                    | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/48 (27%)  17/50 (34%)  14/48 (29%)  15/50 (30%) |25/48 (52%)  28/50 (56%)  34/49 (69%)  32/50 (64%)  | 
|POLY-3 RATE (b)    |     13/44.78     17/47.35     14/45.12     15/45.78    |25/44.64     28/45.88     34/44.45     32/45.94     | 
|POLY-3 PERCENT (g) |     29.0%        35.9%        31.0%        32.8%       |56.0%        61.0%        76.5%        69.7%        | 
|TERMINAL (d)       |     11/38 (29%)  16/41 (39%)  12/39 (31%)  9/33 (27%)  |20/35 (57%)  24/35 (69%)  25/31 (81%)  26/35 (74%)  | 
|FIRST INCIDENCE    |     562          713          607          465         |524          673          503          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.291      P=0.345      P=0.537      P=0.302     |P=0.075      P=0.366      P=0.020 *    P=0.127      | 
|POLY 3             |     P=0.474      P=0.315      P=0.509      P=0.438     |P=0.069      P=0.391      P=0.028 *    P=0.122      | 
|POLY 1.5           |     P=0.484      P=0.308      P=0.506      P=0.444     |P=0.072      P=0.402      P=0.030 *    P=0.128      | 
|POLY 6             |     P=0.462      P=0.327      P=0.514      P=0.431     |P=0.068      P=0.389      P=0.029 *    P=0.121      | 
|LOGISTIC REGRESSION|     P=0.457      P=0.348      P=0.512      P=0.453     |P=0.062      P=0.482      P=0.034 *    P=0.127      | 
|COCH-ARM / FISHERS |     P=0.506      P=0.301      P=0.500      P=0.462     |P=0.104      P=0.426      P=0.062      P=0.161      | 
|ORDER RESTRICTED   |     P=0.525      (e)          (e)          (e)         |P=0.055      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 56      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/50 (0%)    0/48 (0%)    0/50 (0%)   |0/48 (0%)    0/50 (0%)    0/49 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.91      0/47.28      0/44.48      0/43.80     |0/42.57      0/45.35      0/42.00      2/44.39      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.5%         | 
|TERMINAL (d)       |     0/38 (0%)    0/41 (0%)    0/39 (0%)    0/33 (0%)   |0/35 (0%)    0/35 (0%)    0/31 (0%)    1/35 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          142          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.049 *    (e)          (e)          P=0.242      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.246      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.246      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.046 *    (e)          (e)          P=0.248      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.052      (e)          (e)          P=0.435      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.048 *    (e)          (e)          P=0.258      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.033 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/48 (4%)    0/50 (0%)    1/48 (2%)    2/50 (4%)   |3/48 (6%)    2/50 (4%)    5/49 (10%)   14/50 (28%)  | 
|POLY-3 RATE (b)    |     2/43.91      0/47.28      1/44.48      2/44.12     |3/43.35      2/45.96      5/43.39      14/44.79     | 
|POLY-3 PERCENT (g) |     4.6%         0.0%         2.3%         4.5%        |6.9%         4.4%         11.5%        31.3%        | 
|TERMINAL (d)       |     2/38 (5%)    0/41 (0%)    1/39 (3%)    1/33 (3%)   |1/35 (3%)    0/35 (0%)    3/31 (10%)   11/35 (31%)  | 
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      640         |606          561          27           447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.425      P=0.222N     P=0.491N     P=0.657     |P<0.001 **   P=0.482N     P=0.327      P=0.005 **   | 
|POLY 3             |     P=0.461      P=0.221N     P=0.495N     P=0.692N    |P<0.001 **   P=0.473N     P=0.356      P=0.003 **   | 
|POLY 1.5           |     P=0.468      P=0.224N     P=0.497N     P=0.688N    |P<0.001 **   P=0.477N     P=0.357      P=0.003 **   | 
|POLY 6             |     P=0.452      P=0.216N     P=0.494N     P=0.691     |P<0.001 **   P=0.467N     P=0.355      P=0.003 **   | 
|LOGISTIC REGRESSION|     P=0.466      (e)          P=0.491N     P=0.692N    |P<0.001 **   P=0.492N     P=0.478      P=0.005 **   | 
|COCH-ARM / FISHERS |     P=0.479      P=0.237N     P=0.500N     P=0.676N    |P<0.001 **   P=0.480N     P=0.369      P=0.004 **   | 
|ORDER RESTRICTED   |     P=0.403N     (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 57      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tooth                                                                                                                            | 
|     Malformation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/2 (100%)   4/4 (100%)   0/1 (0%)     2/3 (67%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     2/2.00       4/4.00       0/1.00       2/2.26      |0/0.00       0/0.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       0.0%         88.5%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/1 (100%)   3/3 (100%)   0/1 (0%)     2/2 (100%)  |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     561          721          ---          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.277N     (e)          P=0.234N     P=0.527N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.246N     (e)          P=0.333      P=0.991N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.223N     (e)          P=0.333      P=0.825N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.269N     (e)          P=0.333      P=1.000N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.347N     (e)          (e)          P=0.527N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.236N     (e)          P=0.333N     P=0.600N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.169N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |4/49 (8%)    12/50 (24%)  4/50 (8%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     0/43.98      1/47.28      1/46.48      0/43.80     |4/44.21      12/45.63     4/42.33      5/43.85      | 
|POLY-3 PERCENT (g) |     0.0%         2.1%         2.2%         0.0%        |9.1%         26.3%        9.5%         11.4%        | 
|TERMINAL (d)       |     0/38 (0%)    1/41 (2%)    1/41 (2%)    0/33 (0%)   |2/36 (6%)    10/35 (29%)  4/31 (13%)   4/35 (11%)   | 
|FIRST INCIDENCE    |     ---          729 (T)      729 (T)      ---         |606          674          729 (T)      597          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.631N     P=0.515      P=0.515      (e)         |P=0.371N     P=0.032 *    P=0.578      P=0.495      | 
|POLY 3             |     P=0.597N     P=0.514      P=0.511      (e)         |P=0.360N     P=0.029 *    P=0.620      P=0.495      | 
|POLY 1.5           |     P=0.594N     P=0.511      P=0.509      (e)         |P=0.357N     P=0.029 *    P=0.625      P=0.497      | 
|POLY 6             |     P=0.601N     P=0.519      P=0.513      (e)         |P=0.362N     P=0.030 *    P=0.612      P=0.495      | 
|LOGISTIC REGRESSION|     (e)          P=0.515      P=0.515      (e)         |P=0.360N     P=0.034 *    P=0.630      P=0.507      | 
|COCH-ARM / FISHERS |     P=0.592N     P=0.505      P=0.505      (e)         |P=0.334N     P=0.030 *    P=0.631N     P=0.513      | 
|ORDER RESTRICTED   |     P=0.414      (e)          (e)          (e)         |P=0.250N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 58      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder: Transitional Epithelium                                                                                         | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.98      2/47.79      0/46.48      1/43.80     |0/43.57      0/45.35      1/43.03      0/43.40      | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         2.3%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/38 (0%)    1/41 (2%)    0/41 (0%)    1/33 (3%)   |0/36 (0%)    0/35 (0%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |     ---          574          ---          729 (T)     |---          ---          486          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.513      P=0.258      (e)          P=0.472     |P=0.689      (e)          P=0.500      (e)          | 
|POLY 3             |     P=0.540      P=0.256      (e)          P=0.499     |P=0.686      (e)          P=0.498      (e)          | 
|POLY 1.5           |     P=0.542      P=0.251      (e)          P=0.501     |P=0.688      (e)          P=0.497      (e)          | 
|POLY 6             |     P=0.536      P=0.263      (e)          P=0.495     |P=0.686      (e)          P=0.498      (e)          | 
|LOGISTIC REGRESSION|     P=0.554      P=0.196      (e)          P=0.472     |P=0.766      (e)          P=0.630      (e)          | 
|COCH-ARM / FISHERS |     P=0.543      P=0.253      (e)          P=0.505     |P=0.697      (e)          P=0.505      (e)          | 
|ORDER RESTRICTED   |     P=0.324      (e)          (e)          (e)         |P=0.378      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Angiectasis                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/43.63      0/45.35      2/42.33      1/43.40      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         0.0%         4.7%         2.3%         | 
|TERMINAL (d)       |                                                        |1/36 (3%)    0/35 (0%)    2/31 (7%)    1/35 (3%)    | 
|FIRST INCIDENCE    |                                                        |729 (T)      ---          729 (T)      729 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.489      P=0.506N     P=0.448      P=0.756      | 
|POLY 3             |                                                        |P=0.490      P=0.492N     P=0.489      P=0.760      | 
|POLY 1.5           |                                                        |P=0.492      P=0.495N     P=0.489      P=0.759      | 
|POLY 6             |                                                        |P=0.489      P=0.489N     P=0.488      P=0.761N     | 
|LOGISTIC REGRESSION|                                                        |P=0.489      (e)          P=0.448      P=0.756      | 
|COCH-ARM / FISHERS |                                                        |P=0.500      P=0.500N     P=0.500      P=0.753N     | 
|ORDER RESTRICTED   |                                                        |P=0.366      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 59      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |45/50 (90%)  45/50 (90%)  40/50 (80%)  41/50 (82%)  | 
|POLY-3 RATE (b)    |                                                        |45/46.82     45/49.32     40/47.19     41/47.17     | 
|POLY-3 PERCENT (g) |                                                        |96.1%        91.3%        84.8%        86.9%        | 
|TERMINAL (d)       |                                                        |36/36 (100%) 33/35 (94%)  26/31 (84%)  31/35 (89%)  | 
|FIRST INCIDENCE    |                                                        |524          461          486          447          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.287N     P=0.550      P=0.568N     P=0.319N     | 
|POLY 3             |                                                        |P=0.074N     P=0.267N     P=0.048N*    P=0.082N     | 
|POLY 1.5           |                                                        |P=0.090N     P=0.399N     P=0.094N     P=0.124N     | 
|POLY 6             |                                                        |P=0.064N     P=0.155N     P=0.023N*    P=0.053N     | 
|LOGISTIC REGRESSION|                                                        |P=0.137N     P=0.517N     P=0.184N     P=0.204N     | 
|COCH-ARM / FISHERS |                                                        |P=0.105N     P=0.630N     P=0.131N     P=0.194N     | 
|ORDER RESTRICTED   |                                                        |P=0.058N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/43.63      0/45.35      2/42.72      0/43.40      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         0.0%         4.7%         0.0%         | 
|TERMINAL (d)       |                                                        |0/36 (0%)    0/35 (0%)    1/31 (3%)    0/35 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          ---          618          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.593      (e)          P=0.226      (e)          | 
|POLY 3             |                                                        |P=0.588      (e)          P=0.232      (e)          | 
|POLY 1.5           |                                                        |P=0.589      (e)          P=0.232      (e)          | 
|POLY 6             |                                                        |P=0.589      (e)          P=0.233      (e)          | 
|LOGISTIC REGRESSION|                                                        |P=0.597      (e)          P=0.238      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.595      (e)          P=0.247      (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  03/26/03                           EXPERIMENT: 96010 TEST: 04                                            Page 60      
Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -      WATER DISINFECTION BYPRODUCTS (SODIUM                  
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/L       500 MG/L     1000MG/L     2000MG/L    |0 MG/L       500 MG/L     1000MG/L     2000MG/L     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |0/43.63      2/45.35      1/42.72      0/43.40      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         4.4%         2.3%         0.0%         | 
|TERMINAL (d)       |                                                        |0/36 (0%)    2/35 (6%)    0/31 (0%)    0/35 (0%)    | 
|FIRST INCIDENCE    |                                                        |---          729 (T)      618          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.465N     P=0.232      P=0.505      (e)          | 
|POLY 3             |                                                        |P=0.461N     P=0.246      P=0.496      (e)          | 
|POLY 1.5           |                                                        |P=0.463N     P=0.243      P=0.495      (e)          | 
|POLY 6             |                                                        |P=0.459N     P=0.250      P=0.497      (e)          | 
|LOGISTIC REGRESSION|                                                        |P=0.463N     P=0.232      P=0.522      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.461N     P=0.247      P=0.500      (e)          | 
|ORDER RESTRICTED   |                                                        |P=0.328      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    

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