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TDMS Study 97006-01 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Battelle Northwest                              METHYL ISOBUTYL KETONE                                         DATE: 05/11/04  
EXPERIMENT: 97006 TEST: 01                                                                                        TIME: 08:41:16    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                        NTP:  C97006      
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: BATTELLE TOXICOLOGY NORTHWEST                    METHYL ISOBUTYL KETONE                                      DATE: 05/11/04    
EXPERIMENT: 97006 TEST: 01                                                                                        TIME:  8:54:00    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: RESPIRATORY EX                                         NTP:  C97006      
CONT: N01-ES-05452                                                                                                CAS: 108-10-1     
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                                     
                          TWO YEAR RESPIRATORY EX STUDY OF METHYL ISOBUTYL KETONE                                                   
==========================================================================================================                          
WEEK     CONTROL                450 PPM                  900 PPM                  1800 PPM                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B       104.1       50       103.5     99.4    50     102.9     98.8    50     102.0     98.0    50                               
  1       116.5       50       115.4     99.1    50     114.8     98.5    50     113.4     97.3    50                               
  2       158.6       50       157.4     99.2    50     158.3     99.8    50     157.2     99.1    50                               
  3       186.7       50       187.1    100.2    50     189.7    101.6    50     190.9    102.2    50                               
  4       209.4       50       210.4    100.5    50     213.8    102.1    50     217.4    103.8    50                               
  5       231.5       50       233.6    100.9    50     237.7    102.7    50     240.8    104.0    50                               
  6       248.1       50       249.5    100.6    50     254.0    102.4    50     257.1    103.6    50                               
  7       262.8       50       265.5    101.0    50     269.1    102.4    50     273.4    104.0    50                               
  8       277.2       50       281.0    101.4    50     282.1    101.8    50     287.4    103.7    50                               
  9       290.2       50       292.4    100.8    50     296.5    102.2    49     300.3    103.5    50                               
 10       300.8       50       303.7    101.0    50     307.0    102.1    49     311.9    103.7    50                               
 11       310.5       50       312.2    100.5    50     316.3    101.9    49     320.7    103.3    50                               
 12       320.2       50       322.6    100.7    50     326.8    102.1    49     333.1    104.0    50                               
 13       331.3       50       332.6    100.4    50     335.6    101.3    49     342.9    103.5    50                               
 17       365.3       50       365.3    100.0    50     367.0    100.5    49     374.0    102.4    50                               
 21       387.3       50       387.6    100.1    50     388.5    100.3    49     396.0    102.2    50                               
 25       408.7       50       408.2     99.9    50     407.2     99.6    49     416.2    101.8    50                               
 29       427.1       50       426.6     99.9    50     426.8     99.9    49     432.9    101.4    50                               
 33       438.1       50       440.8    100.6    50     439.7    100.4    48     445.9    101.8    50                               
 37       450.1       50       451.2    100.2    50     448.9     99.7    48     453.6    100.8    50                               
 42       459.5       50       461.4    100.4    50     454.4     98.9    48     465.1    101.2    50                               
 45       472.1       50       472.0    100.0    50     467.9     99.1    48     475.1    100.6    50                               
 49       478.6       50       481.9    100.7    49     475.0     99.2    48     481.0    100.5    50                               
 53       487.8       50       490.3    100.5    49     481.2     98.6    48     487.8    100.0    50                               
 57       492.8       50       495.7    100.6    49     485.6     98.5    48     492.2     99.9    50                               
 61       497.5       50       501.5    100.8    47     490.2     98.5    48     495.8     99.7    50                               
 65       503.7       50       504.4    100.1    47     491.9     97.7    48     499.3     99.1    50                               
 69       506.5       49       508.3    100.4    46     495.4     97.8    48     501.9     99.1    50                               
 73       506.9       47       511.6    100.9    46     499.6     98.6    48     503.2     99.3    49                               
 77       514.7       47       517.5    100.5    46     498.3     96.8    48     502.8     97.7    49                               
 81       521.7       46       524.8    100.6    45     504.9     96.8    45     504.5     96.7    48                               
 85       526.0       44       522.5     99.3    45     503.3     95.7    43     506.0     96.2    47                               
 89       525.1       44       525.7    100.1    39     505.0     96.2    42     505.0     96.2    42                               
 91       527.2       42       523.6     99.3    39     502.8     95.4    41     496.9     94.3    40                               
 93       527.3       42       523.9     99.4    38     508.9     96.5    39     502.8     95.4    34                               
 95       523.4       42       528.5    101.0    34     500.7     95.7    38     496.8     94.9    31                               
 97       521.4       41       532.3    102.1    32     499.7     95.8    35     494.8     94.9    28                               
 99       528.6       37       524.8     99.3    31     489.5     92.6    34     484.6     91.7    27                               
101       529.3       34       521.2     98.5    30     486.5     91.9    29     487.6     92.1    21                               
103       521.4       33       507.6     97.4    29     489.4     93.9    26     489.9     94.0    19                               
TERM. SAC.            32                         28                       25                       19                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                   
                          TWO YEAR RESPIRATORY EX STUDY OF METHYL ISOBUTYL KETONE                                                   
==========================================================================================================                          
WEEK     CONTROL                450 PPM                  900 PPM                  1800 PPM                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        93.5       50        92.2     98.6    50      92.1     98.5    50      93.3     99.8    50                               
  1       100.3       50        98.8     98.5    50      98.5     98.2    50     100.2     99.9    50                               
  2       121.6       50       120.6     99.2    50     120.3     98.9    50     123.2    101.3    50                               
  3       134.0       50       132.9     99.2    50     133.8     99.9    50     136.4    101.8    50                               
  4       142.0       50       144.0    101.4    50     144.7    101.9    50     147.2    103.7    50                               
  5       153.2       50       153.4    100.1    50     155.2    101.3    50     156.9    102.4    50                               
  6       160.0       50       161.7    101.1    50     162.8    101.8    50     164.8    103.0    50                               
  7       165.6       50       167.7    101.3    50     168.9    102.0    50     171.5    103.6    50                               
  8       170.2       50       172.5    101.4    50     173.4    101.9    50     175.3    103.0    50                               
  9       174.5       50       177.0    101.4    50     177.7    101.8    50     180.7    103.6    50                               
 10       180.2       50       182.7    101.4    50     184.1    102.2    50     186.1    103.3    50                               
 11       182.8       50       186.6    102.1    50     188.0    102.8    50     189.8    103.8    50                               
 12       187.2       50       190.1    101.5    50     192.8    103.0    50     194.4    103.8    50                               
 13       190.2       50       193.1    101.5    50     195.7    102.9    50     197.2    103.7    50                               
 17       205.7       50       207.5    100.9    50     209.9    102.0    50     212.0    103.1    50                               
 21       213.2       50       214.4    100.6    50     217.4    102.0    50     217.9    102.2    50                               
 25       225.2       50       225.4    100.1    50     228.4    101.4    50     227.9    101.2    50                               
 29       234.3       50       233.6     99.7    50     236.6    101.0    50     236.2    100.8    50                               
 33       241.2       50       239.4     99.3    50     244.8    101.5    50     241.2    100.0    50                               
 37       249.5       50       248.4     99.6    50     252.8    101.3    50     247.9     99.4    50                               
 42       258.0       50       256.4     99.4    50     258.8    100.3    50     256.3     99.3    50                               
 45       268.1       50       265.4     99.0    50     269.3    100.4    50     265.8     99.1    50                               
 49       278.8       50       277.5     99.5    50     282.3    101.3    50     276.7     99.2    50                               
 53       291.5       49       290.6     99.7    49     295.4    101.3    50     290.0     99.5    49                               
 57       300.2       49       299.2     99.7    49     303.7    101.2    50     296.4     98.7    48                               
 61       310.7       49       308.9     99.4    49     315.6    101.6    50     307.0     98.8    48                               
 65       319.2       48       314.0     98.4    49     322.6    101.1    50     312.0     97.7    47                               
 69       325.5       48       321.7     98.8    48     328.5    100.9    50     316.5     97.2    47                               
 73       335.8       48       330.0     98.3    48     336.9    100.3    48     327.5     97.5    44                               
 77       343.9       47       337.2     98.1    47     345.0    100.3    47     334.7     97.3    44                               
 81       350.0       47       343.0     98.0    45     350.6    100.2    46     339.5     97.0    43                               
 85       354.5       45       345.7     97.5    43     352.6     99.5    43     345.2     97.4    43                               
 89       363.3       43       356.9     98.2    42     357.2     98.3    40     347.7     95.7    43                               
 91       365.2       43       359.4     98.4    42     357.5     97.9    39     350.9     96.1    42                               
 93       365.4       41       360.1     98.5    42     369.8    101.2    35     350.2     95.8    42                               
 95       365.0       41       357.6     98.0    42     368.8    101.0    33     352.7     96.6    41                               
 97       365.6       41       359.8     98.4    41     373.4    102.1    31     354.8     97.0    40                               
 99       362.0       40       354.2     97.8    41     366.2    101.2    30     356.9     98.6    36                               
101       358.8       39       350.3     97.6    40     370.9    103.4    29     359.9    100.3    34                               
103       362.9       35       358.4     98.8    36     375.4    103.4    28     358.3     98.7    34                               
TERM. SAC.            35                         34                       26                       32                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.