National Toxicology Program

National Toxicology Program
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TDMS Study 97006-01 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                  METHYL ISOBUTYL KETONE                                DATE: 05/11/04       
EXPERIMENT: 97006 TEST: 01                                                                                     TIME: 09:02:01       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05452                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C97006       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 108-10-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1/RATS                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                  METHYL ISOBUTYL KETONE                                DATE: 05/11/04       
EXPERIMENT: 97006 TEST: 01                                                                                     TIME: 09:02:01       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05452                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C97006       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 108-10-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                 METHYL ISOBUTYL KETONE                                                                           
===============================================================                                                                     
Male Rats                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Adrenal Medulla                        Hyperplasia                                                                                  
Eye: Lens                              Cataract                                                                                     
Kidney                                 Infarct                                                                                      
                                       Nephropathy                                                                                  
Kidney: Papilla                        Mineralization                                                                               
Kidney: Pelvis, Transitional Epithelium                                                                                             
                                       Hyperplasia                                                                                  
Kidney: Renal Tubule                   Accumulation, Hyaline Droplet                                                                
                                       Hyperplasia                                                                                  
Liver                                  Basophilic Focus                                                                             
                                       Degeneration Cystic                                                                          
                                       Eosinophilic Focus                                                                           
                                       Hepatodiaphragmatic Nodule                                                                   
                                       Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Liver: Bile Duct                       Hyperplasia                                                                                  
Liver: Hepatocyte                      Regeneration                                                                                 
Lung                                   Inflammation Chronic                                                                         
Lung: Alveolus                         Emphysema                                                                                    
Lymph Node: Pancreatic                 Ectasia                                                                                      
Mammary Gland                          Galactocele                                                                                  
Nose                                   Foreign Body                                                                                 
                                       Inflammation                                                                                 
Nose: Goblet Cell                      Hyperplasia                                                                                  
Pituitary Gland                        Hemorrhage                                                                                   
Pleura                                 Fibrosis                                                                                     
                                       Inflammation Chronic                                                                         
Skin                                   Inflammation Granulomatous                                                                   
Spleen                                 Fibrosis                                                                                     
Stomach, Forestomach                   Ulcer                                                                                        
Testes: Germinal Epithelium            Atrophy                                                                                      
===============================================================                                                                     
Female Rats                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Kidney                                 Nephropathy                                                                                  
Kidney: Pelvis, Transitional Epithelium                                                                                             
                                       Mineralization                                                                               
Liver                                  Basophilic Focus                                                                             
                                       Necrosis                                                                                     
Lung                                   Inflammation Chronic                                                                         
Lung: Alveolus                         Infiltration Cellular Histiocyte                                                             
Nose                                   Inflammation                                                                                 
Nose: Nasolacrimal Duct                Inflammation                                                                                 
Pleura                                 Fibrosis                                                                                     
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Northwest                                  METHYL ISOBUTYL KETONE                                DATE: 05/11/04       
EXPERIMENT: 97006 TEST: 01                                                                                     TIME: 09:02:01       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05452                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C97006       
PATHOLOGIST: RENNE, ROGER                                                                                      CAS: 108-10-1        
                                       Inflammation Chronic                                                                         
===============================================================                                                                     
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE               
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   3/48 (6%)    6/50 (12%)   3/50 (6%)   |9/50 (18%)   4/50 (8%)    13/50 (26%)  9/50 (18%)   | 
|POLY-3 RATE (b)    |     7/45.31      3/40.91      6/42.42      3/41.95     |9/45.20      4/45.36      13/44.44     9/43.50      | 
|POLY-3 PERCENT (g) |     15.5%        7.3%         14.2%        7.2%        |19.9%        8.8%         29.3%        20.7%        | 
|TERMINAL (d)       |     4/32 (13%)   1/28 (4%)    4/25 (16%)   0/19 (0%)   |7/35 (20%)   2/34 (6%)    6/26 (23%)   7/32 (22%)   | 
|FIRST INCIDENCE    |     588          618          637          623         |643          539          513          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.391N     P=0.226N     P=0.583      P=0.344N    |P=0.255      P=0.131N     P=0.108      P=0.527      | 
|POLY 3             |     P=0.215N     P=0.201N     P=0.551N     P=0.189N    |P=0.274      P=0.113N     P=0.216      P=0.568      | 
|POLY 1.5           |     P=0.200N     P=0.192N     P=0.537N     P=0.173N    |P=0.289      P=0.115N     P=0.228      P=0.580      | 
|POLY 6             |     P=0.250N     P=0.212N     P=0.575N     P=0.225N    |P=0.260      P=0.110N     P=0.195      P=0.560      | 
|LOGISTIC REGRESSION|     P=0.204N     P=0.176N     P=0.538N     P=0.158N    |P=0.305      P=0.118N     P=0.227      P=0.562      | 
|COCH-ARM / FISHERS |     P=0.190N     P=0.176N     P=0.500N     P=0.159N    |P=0.319      P=0.117N     P=0.235      P=0.602N     | 
|ORDER RESTRICTED   |     P=0.165N     (e)          (e)          (e)         |P=0.156      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  18/48 (38%)  18/50 (36%)  24/50 (48%) |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     13/45.31     18/42.20     18/43.63     24/45.14    |0/44.82      2/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     28.7%        42.7%        41.3%        53.2%       |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     10/32 (31%)  11/28 (39%)  8/25 (32%)   9/19 (47%)  |0/35 (0%)    2/34 (6%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     588          420          637          498         |---          727 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.107      P=0.083      P<0.001 **  |P=0.431N     P=0.232      (e)          (e)          | 
|POLY 3             |     P=0.014 *    P=0.123      P=0.151      P=0.012 *   |P=0.416N     P=0.236      (e)          (e)          | 
|POLY 1.5           |     P=0.017 *    P=0.134      P=0.158      P=0.015 *   |P=0.411N     P=0.236      (e)          (e)          | 
|POLY 6             |     P=0.010 *    P=0.114      P=0.143      P=0.008 **  |P=0.422N     P=0.236      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.013 *    P=0.121      P=0.140      P=0.014 *   |(e)          P=0.232      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.020 *    P=0.157      P=0.194      P=0.019 *   |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.009 **   (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Compression                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   8/49 (16%)   3/50 (6%)    6/50 (12%)  |8/50 (16%)   11/50 (22%)  10/50 (20%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     8/46.16      8/42.44      3/42.32      6/43.07     |8/45.70      11/47.04     10/45.27     7/44.39      | 
|POLY-3 PERCENT (g) |     17.3%        18.9%        7.1%         13.9%       |17.5%        23.4%        22.1%        15.8%        | 
|TERMINAL (d)       |     3/32 (9%)    3/28 (11%)   2/25 (8%)    1/19 (5%)   |2/35 (6%)    4/34 (12%)   1/26 (4%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     505          618          660          498         |606          455          513          489          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.442N     P=0.498      P=0.170N     P=0.605N    |P=0.442N     P=0.316      P=0.275      P=0.555N     | 
|POLY 3             |     P=0.276N     P=0.536      P=0.127N     P=0.441N    |P=0.392N     P=0.329      P=0.388      P=0.525N     | 
|POLY 1.5           |     P=0.258N     P=0.554      P=0.119N     P=0.413N    |P=0.378N     P=0.320      P=0.397      P=0.516N     | 
|POLY 6             |     P=0.315N     P=0.519      P=0.142N     P=0.495N    |P=0.408N     P=0.340      P=0.366      P=0.533N     | 
|LOGISTIC REGRESSION|     P=0.232N     P=0.586N     P=0.093N     P=0.325N    |P=0.300N     P=0.311      P=0.450      P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.242N     P=0.590      P=0.100N     P=0.387N    |P=0.354N     P=0.306      P=0.398      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.241N     (e)          (e)          (e)         |P=0.424N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   3/49 (6%)    6/50 (12%)   4/50 (8%)   |5/50 (10%)   4/50 (8%)    10/50 (20%)  5/50 (10%)   | 
|POLY-3 RATE (b)    |     5/45.66      3/41.36      6/44.67      4/42.21     |5/45.54      4/45.66      10/44.29     5/44.02      | 
|POLY-3 PERCENT (g) |     11.0%        7.3%         13.4%        9.5%        |11.0%        8.8%         22.6%        11.4%        | 
|TERMINAL (d)       |     0/32 (0%)    1/28 (4%)    1/25 (4%)    0/19 (0%)   |1/35 (3%)    1/34 (3%)    0/26 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     554          621          205          638         |606          562          546          637          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.467      P=0.430N     P=0.439      P=0.609     |P=0.387      P=0.509N     P=0.079      P=0.590      | 
|POLY 3             |     P=0.563N     P=0.412N     P=0.484      P=0.549N    |P=0.405      P=0.498N     P=0.115      P=0.609      | 
|POLY 1.5           |     P=0.543N     P=0.395N     P=0.488      P=0.524N    |P=0.417      P=0.499N     P=0.124      P=0.615      | 
|POLY 6             |     P=0.519      P=0.432N     P=0.473      P=0.595N    |P=0.397      P=0.497N     P=0.102      P=0.605      | 
|LOGISTIC REGRESSION|     P=0.509N     P=0.339N     P=0.619N     P=0.464N    |P=0.475      P=0.493N     P=0.147      P=0.628N     | 
|COCH-ARM / FISHERS |     P=0.529N     P=0.369N     P=0.500      P=0.500N    |P=0.442      P=0.500N     P=0.131      P=0.630N     | 
|ORDER RESTRICTED   |     P=0.564      (e)          (e)          (e)         |P=0.254      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Brain                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.48      0/40.90      0/42.07      0/41.33     |0/44.82      0/44.54      1/42.16      2/43.74      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.4%         4.6%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          674          637          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.073      (e)          P=0.457      P=0.240      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.067      (e)          P=0.488      P=0.232      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.068      (e)          P=0.494      P=0.233      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.067      (e)          P=0.477      P=0.232      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.075      (e)          P=0.505      P=0.251      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.070      (e)          P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.071      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/45.10      3/44.62      1/41.95      1/43.18      | 
|POLY-3 PERCENT (g) |                                                        |4.4%         6.7%         2.4%         2.3%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    2/34 (6%)    1/26 (4%)    1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |650          707          727 (T)      727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.323N     P=0.494      P=0.589N     P=0.521N     | 
|POLY 3             |                                                        |P=0.297N     P=0.495      P=0.525N     P=0.515N     | 
|POLY 1.5           |                                                        |P=0.290N     P=0.497      P=0.512N     P=0.510N     | 
|POLY 6             |                                                        |P=0.305N     P=0.494      P=0.547N     P=0.520N     | 
|LOGISTIC REGRESSION|                                                        |P=0.299N     P=0.498      P=0.520N     P=0.508N     | 
|COCH-ARM / FISHERS |                                                        |P=0.279N     P=0.500      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.346N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Clitoral Gland                                                                                                                   | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    3/50 (6%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.82      3/44.99      1/41.95      1/43.18      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         6.7%         2.4%         2.3%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    2/34 (6%)    1/26 (4%)    1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |727 (T)      594          727 (T)      727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.483N     P=0.297      P=0.694      P=0.742      | 
|POLY 3             |                                                        |P=0.462N     P=0.307      P=0.746      P=0.752      | 
|POLY 1.5           |                                                        |P=0.455N     P=0.306      P=0.753      P=0.755      | 
|POLY 6             |                                                        |P=0.470N     P=0.309      P=0.733      P=0.750      | 
|LOGISTIC REGRESSION|                                                        |P=0.459N     P=0.305      P=0.694      P=0.742      | 
|COCH-ARM / FISHERS |                                                        |P=0.444N     P=0.309      P=0.753N     P=0.753N     | 
|ORDER RESTRICTED   |                                                        |P=0.459N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye                                                                                                                              | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/45 (0%)    0/46 (0%)    0/48 (0%)   |0/49 (0%)    1/50 (2%)    2/48 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.48      0/38.08      0/38.15      0/39.38     |0/43.89      1/44.77      2/41.30      0/42.51      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         2.2%         4.8%         0.0%         | 
|TERMINAL (d)       |     0/31 (0%)    0/26 (0%)    0/22 (0%)    0/18 (0%)   |0/35 (0%)    0/34 (0%)    1/25 (4%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          665          489          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.628N     P=0.505      P=0.207      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.631N     P=0.504      P=0.224      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.627N     P=0.504      P=0.229      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.634N     P=0.505      P=0.213      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.585N     P=0.506      P=0.211      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.618N     P=0.505      P=0.242      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.314      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Eye: Lens                                                                                                                        | 
|     Cataract                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/49 (14%)   6/45 (13%)   3/46 (7%)    2/48 (4%)   |2/49 (4%)    3/50 (6%)    4/48 (8%)    4/49 (8%)    | 
|POLY-3 RATE (b)    |     7/43.94      6/38.11      3/38.27      2/39.41     |2/44.31      3/45.13      4/41.15      4/42.51      | 
|POLY-3 PERCENT (g) |     15.9%        15.7%        7.8%         5.1%        |4.5%         6.7%         9.7%         9.4%         | 
|TERMINAL (d)       |     6/31 (19%)   5/26 (19%)   2/22 (9%)    1/18 (6%)   |1/35 (3%)    2/34 (6%)    2/25 (8%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     592          720          695          719         |606          537          581          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.155N     P=0.617      P=0.297N     P=0.244N    |P=0.225      P=0.488      P=0.247      P=0.301      | 
|POLY 3             |     P=0.051N     P=0.610N     P=0.218N     P=0.106N    |P=0.237      P=0.508      P=0.303      P=0.318      | 
|POLY 1.5           |     P=0.046N*    P=0.593N     P=0.209N     P=0.094N    |P=0.245      P=0.509      P=0.316      P=0.325      | 
|POLY 6             |     P=0.065N     P=0.607      P=0.233N     P=0.132N    |P=0.228      P=0.509      P=0.280      P=0.312      | 
|LOGISTIC REGRESSION|     P=0.090N     P=0.611      P=0.226N     P=0.142N    |P=0.257      P=0.514      P=0.334      P=0.324      | 
|COCH-ARM / FISHERS |     P=0.041N*    P=0.567N     P=0.185N     P=0.084N    |P=0.260      P=0.510      P=0.329      P=0.339      | 
|ORDER RESTRICTED   |     P=0.082N     (e)          (e)          (e)         |P=0.297      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart                                                                                                                            | 
|     Cardiomyopathy                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  9/49 (18%)   12/50 (24%)  8/50 (16%)  |1/50 (2%)    1/50 (2%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     14/44.68     9/41.14      12/44.06     8/41.41     |1/44.82      1/44.54      3/42.77      2/43.18      | 
|POLY-3 PERCENT (g) |     31.3%        21.9%        27.2%        19.3%       |2.2%         2.3%         7.0%         4.6%         | 
|TERMINAL (d)       |     12/32 (38%)  8/28 (29%)   8/25 (32%)   7/19 (37%)  |1/35 (3%)    1/34 (3%)    1/26 (4%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     679          720          57           706         |727 (T)      727 (T)      581          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.531      P=0.276N     P=0.519      P=0.554N    |P=0.296      P=0.755      P=0.251      P=0.469      | 
|POLY 3             |     P=0.164N     P=0.227N     P=0.424N     P=0.148N    |P=0.307      P=0.759      P=0.288      P=0.487      | 
|POLY 1.5           |     P=0.146N     P=0.211N     P=0.421N     P=0.128N    |P=0.313      P=0.759      P=0.297      P=0.491      | 
|POLY 6             |     P=0.211N     P=0.247N     P=0.437N     P=0.199N    |P=0.302      P=0.760      P=0.273      P=0.484      | 
|LOGISTIC REGRESSION|     P=0.187N     P=0.275N     P=0.428N     P=0.455N    |P=0.319      P=0.755      P=0.317      P=0.469      | 
|COCH-ARM / FISHERS |     P=0.137N     P=0.185N     P=0.410N     P=0.114N    |P=0.324      P=0.753N     P=0.309      P=0.500      | 
|ORDER RESTRICTED   |     P=0.150N     (e)          (e)          (e)         |P=0.310      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Heart: Atrium                                                                                                                    | 
|     Thrombosis                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    4/49 (8%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.41      4/42.47      3/42.49      1/41.65     |0/44.82      1/44.56      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     4.4%         9.4%         7.1%         2.4%        |0.0%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     588          420          670          638         |---          722          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.381N     P=0.309      P=0.457      P=0.498N    |P=0.574N     P=0.500      (e)          (e)          | 
|POLY 3             |     P=0.333N     P=0.306      P=0.470      P=0.530N    |P=0.574N     P=0.499      (e)          (e)          | 
|POLY 1.5           |     P=0.311N     P=0.314      P=0.478      P=0.515N    |P=0.571N     P=0.499      (e)          (e)          | 
|POLY 6             |     P=0.375N     P=0.297      P=0.457      P=0.558N    |P=0.579N     P=0.499      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.272N     P=0.450      P=0.537      P=0.514N    |P=0.578N     P=0.500      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.289N     P=0.329      P=0.500      P=0.500N    |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.293N     (e)          (e)          (e)         |P=0.386N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Large, Cecum                                                                                                           | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    1/48 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/49 (0%)    0/49 (0%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/43.50      1/40.84      0/42.07      2/41.85     |0/44.82      0/44.13      0/41.61      0/42.84      | 
|POLY-3 PERCENT (g) |     0.0%         2.5%         0.0%         4.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          551          ---          638         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.130      P=0.500      (e)          P=0.201     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.135      P=0.487      (e)          P=0.228     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.141      P=0.492      (e)          P=0.237     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.124      P=0.482      (e)          P=0.213     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.145      P=0.628      (e)          P=0.267     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.147      P=0.500      (e)          P=0.258     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.068      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Infarct                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    4/50 (8%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/44.48      0/41.74      4/43.08      3/41.92     |0/44.82      0/44.54      0/41.95      1/43.36      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         9.3%         7.2%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          544          645         |---          ---          ---          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.021 *    (e)          P=0.056      P=0.079     |P=0.199      (e)          (e)          P=0.495      | 
|POLY 3             |     P=0.033 *    (e)          P=0.056      P=0.108     |P=0.195      (e)          (e)          P=0.493      | 
|POLY 1.5           |     P=0.036 *    (e)          P=0.057      P=0.114     |P=0.196      (e)          (e)          P=0.495      | 
|POLY 6             |     P=0.027 *    (e)          P=0.055      P=0.098     |P=0.194      (e)          (e)          P=0.492      | 
|LOGISTIC REGRESSION|     P=0.040 *    (e)          P=0.068      P=0.126     |P=0.199      (e)          (e)          P=0.502      | 
|COCH-ARM / FISHERS |     P=0.040 *    (e)          P=0.059      P=0.121     |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.034 *    (e)          (e)          (e)         |P=0.114      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     42/50 (84%)  45/50 (90%)  47/50 (94%)  50/50 (100%)|19/50 (38%)  35/50 (70%)  38/50 (76%)  44/50 (88%)  | 
|POLY-3 RATE (b)    |     42/47.30     45/47.55     47/48.09     50/50.00    |19/45.28     35/47.90     38/47.30     44/46.18     | 
|POLY-3 PERCENT (g) |     88.8%        94.6%        97.7%        100.0%      |42.0%        73.1%        80.3%        95.3%        | 
|TERMINAL (d)       |     29/32 (91%)  28/28 (100%) 25/25 (100%) 19/19 (100%)|14/35 (40%)  24/34 (71%)  20/26 (77%)  31/32 (97%)  | 
|FIRST INCIDENCE    |     505          405          205          498         |685          455          513          499          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.090      P=0.020 *    P<0.001 **  |P<0.001 **   P=0.004 **   P<0.001 **   P<0.001 **   | 
|POLY 3             |     P=0.003 **   P=0.225      P=0.061      P=0.011 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 1.5           |     P=0.002 **   P=0.238      P=0.055      P=0.006 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|POLY 6             |     P=0.007 **   P=0.213      P=0.078      P=0.030 *   |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.110      P=0.026 *    P=0.002 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|COCH-ARM / FISHERS |     P=0.002 **   P=0.277      P=0.100      P=0.003 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Papilla                                                                                                                  | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   22/50 (44%)  29/50 (58%) |3/50 (6%)    5/50 (10%)   3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/44.48      6/42.40      22/44.54     29/46.28    |3/44.86      5/44.75      3/42.34      3/43.86      | 
|POLY-3 PERCENT (g) |     2.3%         14.2%        49.4%        62.7%       |6.7%         11.2%        7.1%         6.8%         | 
|TERMINAL (d)       |     1/32 (3%)    3/28 (11%)   11/25 (44%)  12/19 (63%) |2/35 (6%)    3/34 (9%)    1/26 (4%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     726 (T)      621          544          544         |716          693          636          499          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.045 *    P<0.001 **   P<0.001 **  |P=0.525N     P=0.355      P=0.545      P=0.625      | 
|POLY 3             |     P<0.001 **   P=0.048 *    P<0.001 **   P<0.001 **  |P=0.480N     P=0.355      P=0.636      P=0.652      | 
|POLY 1.5           |     P<0.001 **   P=0.051      P<0.001 **   P<0.001 **  |P=0.474N     P=0.355      P=0.649      P=0.655      | 
|POLY 6             |     P<0.001 **   P=0.045 *    P<0.001 **   P<0.001 **  |P=0.487N     P=0.357      P=0.612      P=0.650      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.049 *    P<0.001 **   P<0.001 **  |P=0.478N     P=0.353      P=0.621      P=0.663N     | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.056      P<0.001 **   P<0.001 **  |P=0.463N     P=0.357      P=0.661N     P=0.661N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.561N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis, Transitional Epithelium                                                                                          | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    5/50 (10%)   6/50 (12%)   19/50 (38%) |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.48      5/41.74      6/42.19      19/42.56    |1/44.82      1/44.67      0/41.95      1/43.18      | 
|POLY-3 PERCENT (g) |     2.3%         12.0%        14.2%        44.7%       |2.2%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/32 (3%)    5/28 (18%)   4/25 (16%)   12/19 (63%) |1/35 (3%)    0/34 (0%)    0/26 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      702          609         |727 (T)      693          ---          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.073      P=0.030 *    P<0.001 **  |P=0.645N     P=0.760      P=0.559N     P=0.742      | 
|POLY 3             |     P<0.001 **   P=0.087      P=0.047 *    P<0.001 **  |P=0.623N     P=0.760      P=0.513N     P=0.752      | 
|POLY 1.5           |     P<0.001 **   P=0.092      P=0.049 *    P<0.001 **  |P=0.619N     P=0.760      P=0.506N     P=0.755      | 
|POLY 6             |     P<0.001 **   P=0.080      P=0.044 *    P<0.001 **  |P=0.629N     P=0.761N     P=0.525N     P=0.750      | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.073      P=0.034 *    P<0.001 **  |P=0.631N     P=0.761      (e)          P=0.742      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.102      P=0.056      P<0.001 **  |P=0.616N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.551N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Pelvis, Transitional Epithelium                                                                                          | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |9/50 (18%)   6/50 (12%)   7/50 (14%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.48      0/41.74      0/42.07      0/41.33     |9/45.43      6/45.88      7/42.99      2/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |19.8%        13.1%        16.3%        4.6%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |6/35 (17%)   4/34 (12%)   3/26 (12%)   2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |606          455          616          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.049N*    P=0.310N     P=0.589N     P=0.042N*    | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.035N*    P=0.279N     P=0.439N     P=0.030N*    | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.032N*    P=0.283N     P=0.415N     P=0.028N*    | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.038N*    P=0.277N     P=0.480N     P=0.032N*    | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.028N*    P=0.285N     P=0.427N     P=0.031N*    | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.028N*    P=0.288N     P=0.393N     P=0.026N*    | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.024N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Accumulation, Hyaline Droplet                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.48      0/41.74      2/43.66      2/42.43     |0/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.6%         4.7%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          57           544         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.094      (e)          P=0.242      P=0.249     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.081      (e)          P=0.233      P=0.227     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.084      (e)          P=0.234      P=0.233     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.072      (e)          P=0.229      P=0.214     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.041 *    (e)          P=0.598      P=0.141     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.086      (e)          P=0.247      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.108      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    11/50 (22%)  3/50 (6%)    18/50 (36%) |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.48      11/42.25     3/42.17      18/42.93    |1/44.90      1/44.54      0/41.95      1/43.18      | 
|POLY-3 PERCENT (g) |     2.3%         26.0%        7.1%         41.9%       |2.2%         2.3%         0.0%         2.3%         | 
|TERMINAL (d)       |     1/32 (3%)    9/28 (32%)   2/25 (8%)    9/19 (47%)  |0/35 (0%)    1/34 (3%)    0/26 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      658          702          609         |707          727 (T)      ---          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P<0.001 **   P=0.231      P<0.001 **  |P=0.647N     P=0.760      P=0.559N     P=0.735      | 
|POLY 3             |     P<0.001 **   P<0.001 **   P=0.286      P<0.001 **  |P=0.623N     P=0.759      P=0.514N     P=0.752      | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P=0.291      P<0.001 **  |P=0.619N     P=0.759      P=0.507N     P=0.755      | 
|POLY 6             |     P<0.001 **   P<0.001 **   P=0.278      P<0.001 **  |P=0.629N     P=0.759      P=0.525N     P=0.750      | 
|LOGISTIC REGRESSION|     P<0.001 **   P<0.001 **   P=0.255      P<0.001 **  |P=0.633N     P=0.762      P=0.518N     P=0.753      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.002 **   P=0.309      P<0.001 **  |P=0.616N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.550N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    3/48 (6%)    6/50 (12%)   4/50 (8%)   |1/50 (2%)    2/50 (4%)    3/50 (6%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/44.85      3/40.51      6/43.42      4/41.78     |1/44.82      2/44.99      3/42.23      2/43.77      | 
|POLY-3 PERCENT (g) |     4.5%         7.4%         13.8%        9.6%        |2.2%         4.5%         7.1%         4.6%         | 
|TERMINAL (d)       |     1/32 (3%)    2/28 (7%)    2/25 (8%)    2/19 (11%)  |1/35 (3%)    1/34 (3%)    2/26 (8%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     624          664          539          636         |727 (T)      594          653          548          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.131      P=0.437      P=0.108      P=0.202     |P=0.374      P=0.491      P=0.218      P=0.479      | 
|POLY 3             |     P=0.218      P=0.454      P=0.122      P=0.304     |P=0.389      P=0.501      P=0.284      P=0.492      | 
|POLY 1.5           |     P=0.239      P=0.464      P=0.123      P=0.322     |P=0.394      P=0.500      P=0.295      P=0.494      | 
|POLY 6             |     P=0.180      P=0.443      P=0.118      P=0.273     |P=0.386      P=0.504      P=0.266      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.253      P=0.468      P=0.145      P=0.327     |P=0.411      P=0.502      P=0.268      P=0.514      | 
|COCH-ARM / FISHERS |     P=0.255      P=0.480      P=0.134      P=0.339     |P=0.404      P=0.500      P=0.309      P=0.500      | 
|ORDER RESTRICTED   |     P=0.177      (e)          (e)          (e)         |P=0.331      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx                                                                                                                           | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/48 (4%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.48      2/41.37      2/42.73      2/42.06     |0/44.82      0/44.54      1/41.95      2/43.77      | 
|POLY-3 PERCENT (g) |     0.0%         4.8%         4.7%         4.8%        |0.0%         0.0%         2.4%         4.6%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    1/26 (4%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          338          633          609         |---          ---          727 (T)      548          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.231      P=0.216      P=0.237      P=0.240     |P=0.068      (e)          P=0.441      P=0.229      | 
|POLY 3             |     P=0.224      P=0.221      P=0.228      P=0.225     |P=0.067      (e)          P=0.487      P=0.232      | 
|POLY 1.5           |     P=0.237      P=0.224      P=0.230      P=0.231     |P=0.068      (e)          P=0.494      P=0.233      | 
|POLY 6             |     P=0.201      P=0.218      P=0.225      P=0.212     |P=0.067      (e)          P=0.475      P=0.231      | 
|LOGISTIC REGRESSION|     P=0.245      P=0.394      P=0.259      P=0.235     |P=0.074      (e)          P=0.441      P=0.257      | 
|COCH-ARM / FISHERS |     P=0.247      P=0.237      P=0.247      P=0.247     |P=0.070      (e)          P=0.500      P=0.247      | 
|ORDER RESTRICTED   |     P=0.177      (e)          (e)          (e)         |P=0.071      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Larynx: Epiglottis                                                                                                               | 
|     Metaplasia                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/48 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.48      1/40.47      0/42.07      0/41.33     |0/44.82      1/44.54      2/42.16      2/43.75      | 
|POLY-3 PERCENT (g) |     0.0%         2.5%         0.0%         0.0%        |0.0%         2.3%         4.7%         4.6%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    1/34 (3%)    1/26 (4%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          677          ---          ---         |---          727 (T)      674          548          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.612N     P=0.457      (e)          (e)         |P=0.147      P=0.494      P=0.185      P=0.223      | 
|POLY 3             |     P=0.577N     P=0.481      (e)          (e)         |P=0.153      P=0.499      P=0.224      P=0.232      | 
|POLY 1.5           |     P=0.573N     P=0.485      (e)          (e)         |P=0.155      P=0.499      P=0.231      P=0.233      | 
|POLY 6             |     P=0.583N     P=0.478      (e)          (e)         |P=0.152      P=0.499      P=0.212      P=0.231      | 
|LOGISTIC REGRESSION|     P=0.565N     P=0.496      (e)          (e)         |P=0.162      P=0.494      P=0.224      P=0.257      | 
|COCH-ARM / FISHERS |     P=0.565N     P=0.490      (e)          (e)         |P=0.160      P=0.500      P=0.247      P=0.247      | 
|ORDER RESTRICTED   |     P=0.378N     (e)          (e)          (e)         |P=0.145      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Basophilic Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     11/50 (22%)  5/50 (10%)   13/50 (26%)  4/50 (8%)   |36/50 (72%)  24/50 (48%)  26/50 (52%)  20/50 (40%)  | 
|POLY-3 RATE (b)    |     11/44.66     5/41.74      13/42.29     4/41.58     |36/46.85     24/44.73     26/44.53     20/43.64     | 
|POLY-3 PERCENT (g) |     24.6%        12.0%        30.7%        9.6%        |76.8%        53.7%        58.4%        45.8%        | 
|TERMINAL (d)       |     10/32 (31%)  5/28 (18%)   11/25 (44%)  3/19 (16%)  |28/35 (80%)  22/34 (65%)  17/26 (65%)  18/32 (56%)  | 
|FIRST INCIDENCE    |     679          726 (T)      695          659         |370          693          590          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430N     P=0.135N     P=0.175      P=0.240N    |P=0.018N*    P=0.018N*    P=0.426N     P=0.005N**   | 
|POLY 3             |     P=0.120N     P=0.106N     P=0.345      P=0.057N    |P=0.003N**   P=0.012N*    P=0.038N*    P<0.001N**   | 
|POLY 1.5           |     P=0.107N     P=0.098N     P=0.360      P=0.050N    |P=0.003N**   P=0.012N*    P=0.033N*    P<0.001N**   | 
|POLY 6             |     P=0.157N     P=0.118N     P=0.318      P=0.076N    |P=0.004N**   P=0.014N*    P=0.054N     P<0.001N**   | 
|LOGISTIC REGRESSION|     P=0.304N     P=0.136N     P=0.236      P=0.143N    |P=0.004N**   P=0.009N**   P=0.059N     P<0.001N**   | 
|COCH-ARM / FISHERS |     P=0.105N     P=0.086N     P=0.408      P=0.045N*   |P=0.003N**   P=0.012N*    P=0.032N*    P<0.001N**   | 
|ORDER RESTRICTED   |     P=0.050N     (e)          (e)          (e)         |P<0.001N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Clear Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  13/50 (26%)  17/50 (34%)  9/50 (18%)  |11/50 (22%)  10/50 (20%)  11/50 (22%)  7/50 (14%)   | 
|POLY-3 RATE (b)    |     14/44.48     13/41.93     17/42.20     9/41.33     |11/44.82     10/44.60     11/43.31     7/43.36      | 
|POLY-3 PERCENT (g) |     31.5%        31.0%        40.3%        21.8%       |24.5%        22.4%        25.4%        16.1%        | 
|TERMINAL (d)       |     14/32 (44%)  12/28 (43%)  16/25 (64%)  9/19 (47%)  |11/35 (31%)  9/34 (27%)   8/26 (31%)   6/32 (19%)   | 
|FIRST INCIDENCE    |     726 (T)      677          695          726 (T)     |727 (T)      712          581          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.327      P=0.516      P=0.071      P=0.516     |P=0.277N     P=0.528N     P=0.324      P=0.275N     | 
|POLY 3             |     P=0.220N     P=0.574N     P=0.261      P=0.218N    |P=0.214N     P=0.505N     P=0.561      P=0.237N     | 
|POLY 1.5           |     P=0.190N     P=0.547N     P=0.279      P=0.191N    |P=0.206N     P=0.504N     P=0.580      P=0.231N     | 
|POLY 6             |     P=0.301N     P=0.583      P=0.231      P=0.282N    |P=0.219N     P=0.502N     P=0.524      P=0.240N     | 
|LOGISTIC REGRESSION|     P=0.408      P=0.508      P=0.089      P=0.516     |P=0.234N     P=0.491N     P=0.492      P=0.256N     | 
|COCH-ARM / FISHERS |     P=0.172N     P=0.500N     P=0.333      P=0.171N    |P=0.191N     P=0.500N     P=0.595N     P=0.218N     | 
|ORDER RESTRICTED   |     P=0.157N     (e)          (e)          (e)         |P=0.271N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Degeneration Cystic                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.48      0/41.74      1/42.29      3/41.66     |0/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         2.4%         7.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/32 (3%)    0/28 (0%)    0/25 (0%)    1/19 (5%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          670          653         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.047 *    P=0.527N     P=0.718      P=0.168     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.092      P=0.513N     P=0.749      P=0.282     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.095      P=0.508N     P=0.752      P=0.294     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.085      P=0.518N     P=0.745      P=0.258     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.087      (e)          P=0.754      P=0.254     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.097      P=0.500N     P=0.753N     P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.070      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Eosinophilic Focus                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    6/50 (12%)   10/50 (20%)  9/50 (18%)  |3/50 (6%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     2/44.48      6/41.74      10/42.62     9/41.41     |3/44.90      0/44.54      1/41.95      2/43.55      | 
|POLY-3 PERCENT (g) |     4.5%         14.4%        23.5%        21.7%       |6.7%         0.0%         2.4%         4.6%         | 
|TERMINAL (d)       |     2/32 (6%)    6/28 (21%)   6/25 (24%)   8/19 (42%)  |2/35 (6%)    0/34 (0%)    1/26 (4%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      660          705         |707          ---          727 (T)      667          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.091      P=0.006 **   P<0.001 **  |P=0.593N     P=0.125N     P=0.417N     P=0.533N     | 
|POLY 3             |     P=0.016 *    P=0.112      P=0.010 *    P=0.017 *   |P=0.564N     P=0.120N     P=0.330N     P=0.514N     | 
|POLY 1.5           |     P=0.021 *    P=0.120      P=0.011 *    P=0.021 *   |P=0.560N     P=0.120N     P=0.317N     P=0.510N     | 
|POLY 6             |     P=0.009 **   P=0.103      P=0.009 **   P=0.011 *   |P=0.568N     P=0.120N     P=0.352N     P=0.515N     | 
|LOGISTIC REGRESSION|     P=0.003 **   P=0.091      P=0.009 **   P=0.002 **  |P=0.572N     P=0.120N     P=0.382N     P=0.513N     | 
|COCH-ARM / FISHERS |     P=0.027 *    P=0.134      P=0.014 *    P=0.026 *   |P=0.556N     P=0.121N     P=0.309N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.012 *    (e)          (e)          (e)         |P=0.200N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatodiaphragmatic Nodule                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    6/50 (12%)   7/50 (14%)   7/50 (14%)  |8/50 (16%)   12/50 (24%)  9/50 (18%)   5/50 (10%)   | 
|POLY-3 RATE (b)    |     3/45.00      6/42.16      7/42.29      7/41.79     |8/47.36      12/45.13     9/43.73      5/44.19      | 
|POLY-3 PERCENT (g) |     6.7%         14.2%        16.6%        16.8%       |16.9%        26.6%        20.6%        11.3%        | 
|TERMINAL (d)       |     1/32 (3%)    4/28 (14%)   5/25 (20%)   4/19 (21%)  |4/35 (11%)   9/34 (27%)   3/26 (12%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     624          659          695          659         |370          562          581          364          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.034 *    P=0.180      P=0.100      P=0.050     |P=0.207N     P=0.225      P=0.355      P=0.326N     | 
|POLY 3             |     P=0.120      P=0.210      P=0.132      P=0.127     |P=0.180N     P=0.189      P=0.428      P=0.322N     | 
|POLY 1.5           |     P=0.139      P=0.222      P=0.139      P=0.143     |P=0.164N     P=0.201      P=0.459      P=0.306N     | 
|POLY 6             |     P=0.090      P=0.196      P=0.121      P=0.101     |P=0.197N     P=0.181      P=0.388      P=0.336N     | 
|LOGISTIC REGRESSION|     P=0.097      P=0.218      P=0.133      P=0.120     |P=0.117N     P=0.232      P=0.579      P=0.194N     | 
|COCH-ARM / FISHERS |     P=0.156      P=0.243      P=0.159      P=0.159     |P=0.140N     P=0.227      P=0.500      P=0.277N     | 
|ORDER RESTRICTED   |     P=0.127      (e)          (e)          (e)         |P=0.156N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Mixed Cell Focus                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.48      0/41.74      2/42.07      1/41.33     |1/44.82      3/44.57      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         4.8%         2.4%        |2.2%         6.7%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/32 (3%)    0/28 (0%)    2/25 (8%)    1/19 (5%)   |1/35 (3%)    2/34 (6%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          726 (T)      726 (T)     |727 (T)      718          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.348      P=0.527N     P=0.414      P=0.641     |P=0.178N     P=0.304      P=0.559N     P=0.518N     | 
|POLY 3             |     P=0.480      P=0.513N     P=0.481      P=0.744     |P=0.160N     P=0.303      P=0.513N     P=0.507N     | 
|POLY 1.5           |     P=0.493      P=0.508N     P=0.485      P=0.753     |P=0.156N     P=0.304      P=0.506N     P=0.505N     | 
|POLY 6             |     P=0.450      P=0.518N     P=0.472      P=0.727     |P=0.164N     P=0.304      P=0.525N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.348      (e)          P=0.414      P=0.641     |P=0.173N     P=0.307      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.500      P=0.500N     P=0.500      P=0.753N    |P=0.153N     P=0.309      P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.363      (e)          (e)          (e)         |P=0.120N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/44.69      6/43.90      1/42.07      0/41.33     |0/44.82      0/44.54      2/42.94      3/44.64      | 
|POLY-3 PERCENT (g) |     2.2%         13.7%        2.4%         0.0%        |0.0%         0.0%         4.7%         6.7%         | 
|TERMINAL (d)       |     0/32 (0%)    2/28 (7%)    1/25 (4%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     671          405          726 (T)      ---         |---          ---          509          454          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.176N     P=0.048 *    P=0.715      P=0.567N    |P=0.026 *    (e)          P=0.234      P=0.113      | 
|POLY 3             |     P=0.129N     P=0.052      P=0.747      P=0.516N    |P=0.027 *    (e)          P=0.228      P=0.118      | 
|POLY 1.5           |     P=0.117N     P=0.054      P=0.751      P=0.507N    |P=0.027 *    (e)          P=0.233      P=0.118      | 
|POLY 6             |     P=0.153N     P=0.050      P=0.741      P=0.532N    |P=0.027 *    (e)          P=0.218      P=0.119      | 
|LOGISTIC REGRESSION|     P=0.098N     P=0.096      P=0.754      P=0.492N    |P=0.044 *    (e)          P=0.200      P=0.155      | 
|COCH-ARM / FISHERS |     P=0.111N     P=0.056      P=0.753N     P=0.500N    |P=0.028 *    (e)          P=0.247      P=0.121      | 
|ORDER RESTRICTED   |     P=0.054N     (e)          (e)          (e)         |P=0.036 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    2/50 (4%)    0/50 (0%)   |3/50 (6%)    3/50 (6%)    5/50 (10%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/45.00      2/42.57      2/42.59      0/41.33     |3/45.08      3/45.36      5/42.97      4/44.06      | 
|POLY-3 PERCENT (g) |     8.9%         4.7%         4.7%         0.0%        |6.7%         6.6%         11.6%        9.1%         | 
|TERMINAL (d)       |     2/32 (6%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    2/26 (8%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     588          595          637          ---         |685          594          621          454          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.070N     P=0.376N     P=0.414N     P=0.124N    |P=0.338      P=0.654N     P=0.257      P=0.461      | 
|POLY 3             |     P=0.049N*    P=0.363N     P=0.363N     P=0.071N    |P=0.357      P=0.660N     P=0.330      P=0.488      | 
|POLY 1.5           |     P=0.046N*    P=0.354N     P=0.357N     P=0.066N    |P=0.364      P=0.661N     P=0.344      P=0.492      | 
|POLY 6             |     P=0.057N     P=0.373N     P=0.372N     P=0.084N    |P=0.348      P=0.656N     P=0.307      P=0.484      | 
|LOGISTIC REGRESSION|     P=0.041N*    P=0.303N     P=0.333N     P=0.063N    |P=0.398      P=0.660N     P=0.360      P=0.514      | 
|COCH-ARM / FISHERS |     P=0.044N*    P=0.339N     P=0.339N     P=0.059N    |P=0.375      P=0.661N     P=0.357      P=0.500      | 
|ORDER RESTRICTED   |     P=0.034N*    (e)          (e)          (e)         |P=0.420      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 16      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Bile Duct                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    4/50 (8%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.48      3/41.85      4/42.49      4/42.03     |0/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         7.2%         9.4%         9.5%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    1/28 (4%)    1/25 (4%)    1/19 (5%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          705          670          609         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.027 *    P=0.104      P=0.049 *    P=0.032 *   |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.065      P=0.108      P=0.054      P=0.053     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.072      P=0.112      P=0.056      P=0.057     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.052      P=0.103      P=0.052      P=0.046 *   |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.068      P=0.100      P=0.057      P=0.065     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.078      P=0.121      P=0.059      P=0.059     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.049 *    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Centrilobular                                                                                                             | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    1/50 (2%)    4/50 (8%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.95      1/42.31      1/42.07      4/42.71     |0/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     2.2%         2.4%         2.4%         9.4%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    1/25 (4%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     588          551          726 (T)      498         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.054      P=0.755      P=0.725      P=0.156     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.062      P=0.747      P=0.746      P=0.163     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.065      P=0.752      P=0.750      P=0.172     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.056      P=0.741      P=0.739      P=0.146     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.065      P=0.673N     P=0.753N     P=0.170     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.067      P=0.753N     P=0.753N     P=0.181     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.064      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 17      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Regeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    1/50 (2%)    4/50 (8%)   |1/50 (2%)    1/50 (2%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.48      2/41.74      1/42.07      4/42.18     |1/44.90      1/44.54      2/42.05      2/43.31      | 
|POLY-3 PERCENT (g) |     0.0%         4.8%         2.4%         9.5%        |2.2%         2.3%         4.8%         4.6%         | 
|TERMINAL (d)       |     0/32 (0%)    2/28 (7%)    1/25 (4%)    1/19 (5%)   |0/35 (0%)    1/34 (3%)    1/26 (4%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      726 (T)      621         |707          727 (T)      702          695          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.016 *    P=0.209      P=0.451      P=0.038 *   |P=0.295      P=0.760      P=0.402      P=0.462      | 
|POLY 3             |     P=0.034 *    P=0.223      P=0.489      P=0.053     |P=0.323      P=0.759      P=0.477      P=0.487      | 
|POLY 1.5           |     P=0.037 *    P=0.228      P=0.492      P=0.057     |P=0.328      P=0.759      P=0.489      P=0.492      | 
|POLY 6             |     P=0.030 *    P=0.217      P=0.484      P=0.047 *   |P=0.318      P=0.759      P=0.458      P=0.485      | 
|LOGISTIC REGRESSION|     P=0.036 *    P=0.209      P=0.451      P=0.068     |P=0.318      P=0.762      P=0.457      P=0.487      | 
|COCH-ARM / FISHERS |     P=0.040 *    P=0.247      P=0.500      P=0.059     |P=0.337      P=0.753N     P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.016 *    (e)          (e)          (e)         |P=0.417      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/49 (10%)   5/50 (10%)   0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.10      5/43.38      5/43.71      0/41.33     |0/44.82      0/44.54      0/41.95      1/43.51      | 
|POLY-3 PERCENT (g) |     4.4%         11.5%        11.4%        0.0%        |0.0%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    2/25 (8%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     588          405          205          ---         |---          ---          ---          637          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.232N     P=0.191      P=0.178      P=0.277N    |P=0.202      (e)          (e)          P=0.500      | 
|POLY 3             |     P=0.195N     P=0.200      P=0.203      P=0.257N    |P=0.195      (e)          (e)          P=0.494      | 
|POLY 1.5           |     P=0.173N     P=0.203      P=0.207      P=0.247N    |P=0.196      (e)          (e)          P=0.496      | 
|POLY 6             |     P=0.243N     P=0.195      P=0.194      P=0.278N    |P=0.195      (e)          (e)          P=0.493      | 
|LOGISTIC REGRESSION|     P=0.131N     P=0.343      P=0.308      P=0.227N    |P=0.211      (e)          (e)          P=0.520      | 
|COCH-ARM / FISHERS |     P=0.155N     P=0.210      P=0.218      P=0.247N    |P=0.198      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.070N     (e)          (e)          (e)         |P=0.115      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 18      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.48      2/42.11      1/42.17      0/41.33     |0/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         4.8%         2.4%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          420          702          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.517N     P=0.212      P=0.470      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.488N     P=0.225      P=0.489      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.474N     P=0.228      P=0.492      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.514N     P=0.222      P=0.485      (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.446N     P=0.343      P=0.490      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.459N     P=0.242      P=0.500      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.316      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    0/49 (0%)    2/50 (4%)    0/50 (0%)   |2/50 (4%)    10/50 (20%)  7/50 (14%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |     4/44.48      0/41.12      2/42.07      0/41.33     |2/45.31      10/44.73     7/42.94      4/43.32      | 
|POLY-3 PERCENT (g) |     9.0%         0.0%         4.8%         0.0%        |4.4%         22.4%        16.3%        9.2%         | 
|TERMINAL (d)       |     4/32 (13%)   0/28 (0%)    2/25 (8%)    0/19 (0%)   |0/35 (0%)    8/34 (24%)   4/26 (15%)   3/32 (9%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          726 (T)      ---         |606          693          509          691          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123N     P=0.080N     P=0.455N     P=0.145N    |P=0.493      P=0.017 *    P=0.049 *    P=0.305      | 
|POLY 3             |     P=0.061N     P=0.070N     P=0.363N     P=0.070N    |P=0.526      P=0.012 *    P=0.066      P=0.316      | 
|POLY 1.5           |     P=0.059N     P=0.068N     P=0.357N     P=0.065N    |P=0.544      P=0.013 *    P=0.073      P=0.324      | 
|POLY 6             |     P=0.066N     P=0.074N     P=0.374N     P=0.081N    |P=0.509      P=0.012 *    P=0.055      P=0.310      | 
|LOGISTIC REGRESSION|     P=0.123N     (e)          P=0.455N     (e)         |P=0.547      P=0.015 *    P=0.086      P=0.328      | 
|COCH-ARM / FISHERS |     P=0.061N     P=0.061N     P=0.339N     P=0.059N    |P=0.545N     P=0.014 *    P=0.080      P=0.339      | 
|ORDER RESTRICTED   |     P=0.014N*    (e)          (e)          (e)         |P=0.074      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 19      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolar Epithelium                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    7/49 (14%)   4/50 (8%)    4/50 (8%)   |3/50 (6%)    5/50 (10%)   2/50 (4%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     4/44.48      7/41.79      4/42.09      4/41.83     |3/45.45      5/44.54      2/42.26      6/43.64      | 
|POLY-3 PERCENT (g) |     9.0%         16.8%        9.5%         9.6%        |6.6%         11.2%        4.7%         13.8%        | 
|TERMINAL (d)       |     4/32 (13%)   4/28 (14%)   3/25 (12%)   2/19 (11%)  |2/35 (6%)    5/34 (15%)   1/26 (4%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     726 (T)      609          721          622         |523          727 (T)      642          681          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.426      P=0.198      P=0.503      P=0.394     |P=0.200      P=0.343      P=0.593N     P=0.213      | 
|POLY 3             |     P=0.457N     P=0.224      P=0.613      P=0.610     |P=0.218      P=0.345      P=0.533N     P=0.222      | 
|POLY 1.5           |     P=0.435N     P=0.233      P=0.620      P=0.627     |P=0.226      P=0.349      P=0.517N     P=0.228      | 
|POLY 6             |     P=0.503N     P=0.217      P=0.600      P=0.573     |P=0.211      P=0.342      P=0.559N     P=0.218      | 
|LOGISTIC REGRESSION|     P=0.516N     P=0.208      P=0.514      P=0.541     |P=0.225      P=0.354      P=0.484N     P=0.238      | 
|COCH-ARM / FISHERS |     P=0.415N     P=0.251      P=0.643N     P=0.643N    |P=0.240      P=0.357      P=0.500N     P=0.243      | 
|ORDER RESTRICTED   |     P=0.499N     (e)          (e)          (e)         |P=0.185      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Emphysema                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.95      0/41.12      0/42.07      0/41.33     |1/45.24      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         0.0%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/32 (3%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     588          ---          ---          ---         |606          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.137N     P=0.257N     P=0.275N     P=0.293N    |P=0.311N     P=0.514N     P=0.509N     P=0.509N     | 
|POLY 3             |     P=0.108N     P=0.257N     P=0.252N     P=0.256N    |P=0.305N     P=0.503N     P=0.515N     P=0.509N     | 
|POLY 1.5           |     P=0.110N     P=0.252N     P=0.248N     P=0.246N    |P=0.304N     P=0.502N     P=0.507N     P=0.506N     | 
|POLY 6             |     P=0.105N     P=0.264N     P=0.259N     P=0.276N    |P=0.307N     P=0.504N     P=0.528N     P=0.512N     | 
|LOGISTIC REGRESSION|     P=0.110N     P=0.220N     P=0.220N     P=0.225N    |P=0.285N     P=0.491N     P=0.506N     P=0.468N     | 
|COCH-ARM / FISHERS |     P=0.115N     P=0.253N     P=0.247N     P=0.247N    |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.036N*    (e)          (e)          (e)         |P=0.129N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 20      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Alveolus                                                                                                                   | 
|     Infiltration Cellular Histiocyte                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  5/49 (10%)   6/50 (12%)   6/50 (12%)  |13/50 (26%)  2/50 (4%)    5/50 (10%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     10/44.82     5/41.84      6/42.20      6/42.40     |13/45.22     2/44.54      5/42.28      11/43.82     | 
|POLY-3 PERCENT (g) |     22.3%        12.0%        14.2%        14.2%       |28.8%        4.5%         11.8%        25.1%        | 
|TERMINAL (d)       |     8/32 (25%)   3/28 (11%)   5/25 (20%)   2/19 (11%)  |10/35 (29%)  2/34 (6%)    4/26 (15%)   8/32 (25%)   | 
|FIRST INCIDENCE    |     679          595          695          622         |650          727 (T)      636          637          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.533N     P=0.204N     P=0.367N     P=0.531N    |P=0.371      P=0.003N**   P=0.118N     P=0.495N     | 
|POLY 3             |     P=0.247N     P=0.160N     P=0.242N     P=0.239N    |P=0.438      P=0.002N**   P=0.042N*    P=0.441N     | 
|POLY 1.5           |     P=0.235N     P=0.153N     P=0.234N     P=0.221N    |P=0.446      P=0.002N**   P=0.037N*    P=0.431N     | 
|POLY 6             |     P=0.278N     P=0.168N     P=0.260N     P=0.279N    |P=0.430      P=0.002N**   P=0.055N     P=0.445N     | 
|LOGISTIC REGRESSION|     P=0.288N     P=0.171N     P=0.286N     P=0.276N    |P=0.406      P=0.002N**   P=0.065N     P=0.455N     | 
|COCH-ARM / FISHERS |     P=0.227N     P=0.140N     P=0.207N     P=0.207N    |P=0.461      P=0.002N**   P=0.033N*    P=0.408N     | 
|ORDER RESTRICTED   |     P=0.195N     (e)          (e)          (e)         |P=0.038N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Bronchiole                                                                                                                 | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     0/44.48      0/41.12      0/42.07      1/41.33     |1/44.82      2/44.67      2/41.95      3/43.32      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.4%        |2.2%         4.5%         4.8%         6.9%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    1/19 (5%)   |1/35 (3%)    1/34 (3%)    2/26 (8%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          726 (T)     |727 (T)      693          727 (T)      692          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.139      (e)          (e)          P=0.396     |P=0.199      P=0.496      P=0.396      P=0.276      | 
|POLY 3             |     P=0.193      (e)          (e)          P=0.485     |P=0.218      P=0.499      P=0.477      P=0.293      | 
|POLY 1.5           |     P=0.197      (e)          (e)          P=0.493     |P=0.224      P=0.499      P=0.489      P=0.297      | 
|POLY 6             |     P=0.184      (e)          (e)          P=0.470     |P=0.214      P=0.500      P=0.457      P=0.290      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.396     |P=0.211      P=0.498      P=0.396      P=0.287      | 
|COCH-ARM / FISHERS |     P=0.200      (e)          (e)          P=0.500     |P=0.232      P=0.500      P=0.500      P=0.309      | 
|ORDER RESTRICTED   |     P=0.108      (e)          (e)          (e)         |P=0.232      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 21      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung: Interstitium                                                                                                               | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/49 (0%)    3/50 (6%)    1/50 (2%)   |2/50 (4%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/44.48      0/41.12      3/42.66      1/41.70     |2/45.17      2/44.54      2/42.27      1/43.32      | 
|POLY-3 PERCENT (g) |     4.5%         0.0%         7.0%         2.4%        |4.4%         4.5%         4.7%         2.3%         | 
|TERMINAL (d)       |     2/32 (6%)    0/28 (0%)    2/25 (8%)    0/19 (0%)   |0/35 (0%)    2/34 (6%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      ---          539          622         |643          727 (T)      642          692          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.552      P=0.268N     P=0.413      P=0.622N    |P=0.409N     P=0.687      P=0.621      P=0.518N     | 
|POLY 3             |     P=0.567N     P=0.255N     P=0.481      P=0.523N    |P=0.391N     P=0.689      P=0.670      P=0.515N     | 
|POLY 1.5           |     P=0.557N     P=0.250N     P=0.484      P=0.511N    |P=0.384N     P=0.691      P=0.682      P=0.510N     | 
|POLY 6             |     P=0.589N     P=0.260N     P=0.473      P=0.546N    |P=0.398N     P=0.687      P=0.649      P=0.519N     | 
|LOGISTIC REGRESSION|     P=0.553N     (e)          P=0.491      P=0.511N    |P=0.380N     P=0.694      P=0.691N     P=0.498N     | 
|COCH-ARM / FISHERS |     P=0.553N     P=0.253N     P=0.500      P=0.500N    |P=0.373N     P=0.691N     P=0.691N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.429      (e)          (e)          (e)         |P=0.467N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Bronchial                                                                                                            | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/11 (27%)   2/13 (15%)   1/12 (8%)    0/7 (0%)    |2/9 (22%)    0/12 (0%)    0/8 (0%)     0/7 (0%)     | 
|POLY-3 RATE (b)    |     3/10.54      2/11.27      1/11.08      0/5.29      |2/8.08       0/10.62      0/6.90       0/5.64       | 
|POLY-3 PERCENT (g) |     28.5%        17.8%        9.0%         0.0%        |24.8%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/7 (29%)    1/6 (17%)    0/5 (0%)     0/2 (0%)    |1/4 (25%)    0/8 (0%)     0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     588          621          702          ---         |716          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.128N     P=0.550N     P=0.382N     P=0.270N    |P=0.128N     P=0.166N     P=0.267N     P=0.246N     | 
|POLY 3             |     P=0.099N     P=0.467N     P=0.273N     P=0.255N    |P=0.117N     P=0.161N     P=0.260N     P=0.311N     | 
|POLY 1.5           |     P=0.094N     P=0.450N     P=0.267N     P=0.224N    |P=0.118N     P=0.164N     P=0.257N     P=0.302N     | 
|POLY 6             |     P=0.107N     P=0.483N     P=0.284N     P=0.309N    |P=0.119N     P=0.152N     P=0.260N     P=0.312N     | 
|LOGISTIC REGRESSION|     P=0.081N     P=0.390N     P=0.272N     P=0.157N    |P=0.135N     P=0.139N     P=0.251N     P=0.281N     | 
|COCH-ARM / FISHERS |     P=0.087N     P=0.415N     P=0.261N     P=0.202N    |P=0.133N     P=0.171N     P=0.265N     P=0.300N     | 
|ORDER RESTRICTED   |     P=0.182N     (e)          (e)          (e)         |P=0.061N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 22      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Bronchial                                                                                                            | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/11 (0%)    0/13 (0%)    0/12 (0%)    0/7 (0%)    |0/9 (0%)     2/12 (17%)   0/8 (0%)     0/7 (0%)     | 
|POLY-3 RATE (b)    |     0/10.07      0/10.89      0/10.98      0/5.29      |0/8.03       2/11.07      0/6.90       0/5.64       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         18.1%        0.0%         0.0%         | 
|TERMINAL (d)       |     0/7 (0%)     0/6 (0%)     0/5 (0%)     0/2 (0%)    |0/4 (0%)     1/8 (13%)    0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          594          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.436N     P=0.314      (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.492N     P=0.305      (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.488N     P=0.297      (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.490N     P=0.323      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.458N     P=0.311      (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.477N     P=0.314      (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.377N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Bronchial                                                                                                            | 
|     Pigmentation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/11 (9%)    1/13 (8%)    0/12 (0%)    0/7 (0%)    |1/9 (11%)    2/12 (17%)   0/8 (0%)     0/7 (0%)     | 
|POLY-3 RATE (b)    |     1/10.07      1/10.89      0/10.98      0/5.29      |1/8.03       2/11.07      0/6.90       0/5.64       | 
|POLY-3 PERCENT (g) |     9.9%         9.2%         0.0%         0.0%        |12.5%        18.1%        0.0%         0.0%         | 
|TERMINAL (d)       |     1/7 (14%)    1/6 (17%)    0/5 (0%)     0/2 (0%)    |1/4 (25%)    1/8 (13%)    0/4 (0%)     0/4 (0%)     | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          ---         |727 (T)      594          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.405N     P=0.735      P=0.567N     P=0.748N    |P=0.211N     P=0.660      P=0.500N     P=0.500N     | 
|POLY 3             |     P=0.277N     P=0.745N     P=0.483N     P=0.624N    |P=0.250N     P=0.614      P=0.530N     P=0.570N     | 
|POLY 1.5           |     P=0.285N     P=0.737N     P=0.482N     P=0.608N    |P=0.246N     P=0.604      P=0.528N     P=0.563N     | 
|POLY 6             |     P=0.263N     P=0.753N     P=0.485N     P=0.649N    |P=0.252N     P=0.638      P=0.531N     P=0.570N     | 
|LOGISTIC REGRESSION|     P=0.405N     P=0.735      (e)          (e)         |P=0.232N     P=0.612      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.287N     P=0.717N     P=0.478N     P=0.611N    |P=0.234N     P=0.612      P=0.529N     P=0.563N     | 
|ORDER RESTRICTED   |     P=0.402N     (e)          (e)          (e)         |P=0.305N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 23      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node: Pancreatic                                                                                                           | 
|     Ectasia                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/7 (29%)    0/7 (0%)     0/12 (0%)    0/15 (0%)   |0/1 (0%)     0/2 (0%)     0/2 (0%)     0/3 (0%)     | 
|POLY-3 RATE (b)    |     2/6.13       0/6.44       0/9.79       0/11.89     |0/0.69       0/1.92       0/1.38       0/2.17       | 
|POLY-3 PERCENT (g) |     32.6%        0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/3 (33%)    0/3 (0%)     0/2 (0%)     0/4 (0%)    |0/0 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     671          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.123N     P=0.263N     P=0.302N     P=0.242N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.035N*    P=0.202N     P=0.111N     P=0.077N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.035N*    P=0.210N     P=0.109N     P=0.073N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.035N*    P=0.191N     P=0.116N     P=0.085N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.057N     P=0.200N     P=0.125N     P=0.104N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.049N*    P=0.231N     P=0.123N     P=0.091N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.004N**   (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mammary Gland                                                                                                                    | 
|     Galactocele                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/49 (10%)   0/49 (0%)    1/50 (2%)    3/50 (6%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/44.25      0/41.12      1/42.07      3/42.01     |1/44.82      1/44.60      0/41.95      1/43.18      | 
|POLY-3 PERCENT (g) |     11.3%        0.0%         2.4%         7.1%        |2.2%         2.2%         0.0%         2.3%         | 
|TERMINAL (d)       |     4/32 (13%)   0/28 (0%)    1/25 (4%)    1/19 (5%)   |1/35 (3%)    0/34 (0%)    0/26 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     505          ---          726 (T)      609         |727 (T)      712          ---          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.589N     P=0.045N*    P=0.156N     P=0.555N    |P=0.642N     P=0.760      P=0.559N     P=0.742      | 
|POLY 3             |     P=0.417N     P=0.037N*    P=0.113N     P=0.385N    |P=0.623N     P=0.760      P=0.513N     P=0.752      | 
|POLY 1.5           |     P=0.417N     P=0.034N*    P=0.109N     P=0.365N    |P=0.619N     P=0.760      P=0.506N     P=0.755      | 
|POLY 6             |     P=0.423N     P=0.040N*    P=0.120N     P=0.424N    |P=0.629N     P=0.760      P=0.525N     P=0.750      | 
|LOGISTIC REGRESSION|     P=0.423N     P=0.032N*    P=0.102N     P=0.327N    |P=0.635N     P=0.762      (e)          P=0.742      | 
|COCH-ARM / FISHERS |     P=0.421N     P=0.028N*    P=0.098N     P=0.346N    |P=0.616N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.064N     (e)          (e)          (e)         |P=0.551N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 24      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery                                                                                                                        | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/10 (100%) 12/12 (100%) 9/9 (100%)   7/7 (100%)  |18/18 (100%) 15/17 (88%)  15/15 (100%) 14/15 (93%)  | 
|POLY-3 RATE (b)    |     10/10.00     12/12.00     9/9.00       7/7.00      |18/18.00     15/16.12     15/15.00     14/14.24     | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       100.0%       100.0%      |100.0%       93.1%        100.0%       98.3%        | 
|TERMINAL (d)       |     7/7 (100%)   6/6 (100%)   6/6 (100%)   2/2 (100%)  |13/13 (100%) 12/13 (92%)  10/10 (100%) 12/12 (100%) | 
|FIRST INCIDENCE    |     492          595          667          498         |616          594          513          364          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.314N     P=0.257N     (e)          P=0.257N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.718      P=0.429N     (e)          P=0.998N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.647N     P=0.348N     (e)          P=0.819N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.635      P=0.471N     (e)          P=1.000N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.556      P=0.455N     (e)          P=0.948N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.490N     P=0.229N     (e)          P=0.455N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.409N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Foreign Body                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/49 (6%)    4/50 (8%)    7/50 (14%)  |0/50 (0%)    2/50 (4%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/45.15      3/41.12      4/42.66      7/42.00     |0/44.82      2/44.99      2/42.23      1/43.18      | 
|POLY-3 PERCENT (g) |     2.2%         7.3%         9.4%         16.7%       |0.0%         4.5%         4.7%         2.3%         | 
|TERMINAL (d)       |     0/32 (0%)    3/28 (11%)   3/25 (12%)   5/19 (26%)  |0/35 (0%)    1/34 (3%)    1/26 (4%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     505          726 (T)      540          622         |---          594          653          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.003 **   P=0.268      P=0.141      P=0.009 **  |P=0.443      P=0.234      P=0.191      P=0.482      | 
|POLY 3             |     P=0.012 *    P=0.272      P=0.161      P=0.022 *   |P=0.448      P=0.238      P=0.224      P=0.493      | 
|POLY 1.5           |     P=0.014 *    P=0.282      P=0.166      P=0.026 *   |P=0.456      P=0.237      P=0.231      P=0.495      | 
|POLY 6             |     P=0.009 **   P=0.262      P=0.154      P=0.017 *   |P=0.443      P=0.240      P=0.213      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.016 *    P=0.309      P=0.203      P=0.036 *   |P=0.470      P=0.240      P=0.234      P=0.482      | 
|COCH-ARM / FISHERS |     P=0.017 *    P=0.301      P=0.181      P=0.030 *   |P=0.469      P=0.247      P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.010 *    (e)          (e)          (e)         |P=0.221      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 25      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose                                                                                                                             | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    8/49 (16%)   4/50 (8%)    10/50 (20%) |0/50 (0%)    1/50 (2%)    6/50 (12%)   0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.16      8/41.75      4/42.15      10/42.95    |0/44.82      1/44.54      6/42.56      0/43.18      | 
|POLY-3 PERCENT (g) |     8.9%         19.2%        9.5%         23.3%       |0.0%         2.3%         14.1%        0.0%         | 
|TERMINAL (d)       |     2/32 (6%)    6/28 (21%)   3/25 (12%)   5/19 (26%)  |0/35 (0%)    1/34 (3%)    4/26 (15%)   0/32 (0%)    | 
|FIRST INCIDENCE    |     505          621          707          604         |---          727 (T)      636          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.018 *    P=0.129      P=0.524      P=0.021 *   |P=0.491      P=0.494      P=0.008 **   (e)          | 
|POLY 3             |     P=0.072      P=0.139      P=0.605      P=0.057     |P=0.497      P=0.499      P=0.012 *    (e)          | 
|POLY 1.5           |     P=0.081      P=0.149      P=0.615      P=0.065     |P=0.506      P=0.499      P=0.014 *    (e)          | 
|POLY 6             |     P=0.057      P=0.130      P=0.589      P=0.044 *   |P=0.493      P=0.499      P=0.010 *    (e)          | 
|LOGISTIC REGRESSION|     P=0.079      P=0.154      P=0.624      P=0.081     |P=0.511      P=0.494      P=0.014 *    (e)          | 
|COCH-ARM / FISHERS |     P=0.091      P=0.168      P=0.643N     P=0.074     |P=0.526      P=0.500      P=0.013 *    (e)          | 
|ORDER RESTRICTED   |     P=0.036 *    (e)          (e)          (e)         |P=0.061      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Goblet Cell                                                                                                                | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    0/50 (0%)    5/50 (10%)  |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/44.48      1/41.12      0/42.07      5/41.83     |0/44.82      0/44.54      2/41.95      1/43.18      | 
|POLY-3 PERCENT (g) |     2.3%         2.4%         0.0%         12.0%       |0.0%         0.0%         4.8%         2.3%         | 
|TERMINAL (d)       |     1/32 (3%)    1/28 (4%)    0/25 (0%)    3/19 (16%)  |0/35 (0%)    0/34 (0%)    2/26 (8%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          645         |---          ---          727 (T)      727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.006 **   P=0.732      P=0.549N     P=0.035 *   |P=0.227      (e)          P=0.175      P=0.482      | 
|POLY 3             |     P=0.019 *    P=0.743      P=0.511N     P=0.087     |P=0.234      (e)          P=0.223      P=0.493      | 
|POLY 1.5           |     P=0.020 *    P=0.748      P=0.508N     P=0.095     |P=0.237      (e)          P=0.230      P=0.495      | 
|POLY 6             |     P=0.017 *    P=0.738      P=0.516N     P=0.074     |P=0.232      (e)          P=0.210      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.015 *    P=0.732      (e)          P=0.072     |(e)          (e)          P=0.175      P=0.482      | 
|COCH-ARM / FISHERS |     P=0.022 *    P=0.747      P=0.500N     P=0.102     |P=0.246      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.009 **   (e)          (e)          (e)         |P=0.155      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 26      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Nasolacrimal Duct                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    1/50 (2%)    1/50 (2%)   |5/50 (10%)   2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.48      1/41.12      1/42.41      1/42.00     |5/44.82      2/44.54      2/42.27      0/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         2.4%         2.4%        |11.2%        4.5%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    1/28 (4%)    0/25 (0%)    0/19 (0%)   |5/35 (14%)   2/34 (6%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      633          498         |727 (T)      727 (T)      642          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.348      P=0.473      P=0.500      P=0.508     |P=0.032N*    P=0.226N     P=0.335N     P=0.041N*    | 
|POLY 3             |     P=0.366      P=0.484      P=0.490      P=0.489     |P=0.023N*    P=0.218N     P=0.240N     P=0.034N*    | 
|POLY 1.5           |     P=0.378      P=0.488      P=0.492      P=0.495     |P=0.022N*    P=0.218N     P=0.228N     P=0.033N*    | 
|POLY 6             |     P=0.341      P=0.479      P=0.487      P=0.475     |P=0.024N*    P=0.217N     P=0.261N     P=0.034N*    | 
|LOGISTIC REGRESSION|     P=0.391      P=0.473      P=0.527      P=0.249     |P=0.027N*    P=0.226N     P=0.274N     (e)          | 
|COCH-ARM / FISHERS |     P=0.386      P=0.495      P=0.500      P=0.500     |P=0.022N*    P=0.218N     P=0.218N     P=0.028N*    | 
|ORDER RESTRICTED   |     P=0.315      (e)          (e)          (e)         |P=0.011N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Olfactory Epithelium                                                                                                       | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.48      0/41.12      0/42.07      0/41.33     |1/45.13      0/44.54      1/42.16      2/43.79      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         2.4%         4.6%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |643          ---          674          637          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.248      P=0.505N     P=0.716      P=0.500      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.241      P=0.503N     P=0.745      P=0.490      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.244      P=0.502N     P=0.753      P=0.493      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.240      P=0.503N     P=0.732      P=0.488      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.266      P=0.495N     P=0.754N     P=0.530      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.247      P=0.500N     P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.215      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 27      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Degeneration Hyaline                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |9/50 (18%)   3/50 (6%)    8/50 (16%)   9/50 (18%)   | 
|POLY-3 RATE (b)    |     0/44.48      0/41.12      0/42.07      0/41.33     |9/45.21      3/44.71      8/43.04      9/44.19      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |19.9%        6.7%         18.6%        20.4%        | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |8/35 (23%)   0/34 (0%)    4/26 (15%)   6/32 (19%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |616          707          546          489          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.265      P=0.071N     P=0.491      P=0.531      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.310      P=0.061N     P=0.545N     P=0.583      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.317      P=0.061N     P=0.521N     P=0.588      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.304      P=0.060N     P=0.585N     P=0.581      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.307      P=0.062N     P=0.553N     P=0.579      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.330      P=0.061N     P=0.500N     P=0.602N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.289      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Nose: Respiratory Epithelium                                                                                                     | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/49 (2%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/45.15      1/41.12      3/42.66      3/42.05     |0/44.82      2/44.99      2/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     8.9%         2.4%         7.0%         7.1%        |0.0%         4.5%         4.8%         0.0%         | 
|TERMINAL (d)       |     3/32 (9%)    1/28 (4%)    2/25 (8%)    1/19 (5%)   |0/35 (0%)    1/34 (3%)    2/26 (8%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     505          726 (T)      540          604         |---          594          727 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.447      P=0.217N     P=0.595N     P=0.645     |P=0.529N     P=0.234      P=0.175      (e)          | 
|POLY 3             |     P=0.573N     P=0.208N     P=0.531N     P=0.539N    |P=0.518N     P=0.238      P=0.223      (e)          | 
|POLY 1.5           |     P=0.564N     P=0.200N     P=0.524N     P=0.519N    |P=0.512N     P=0.237      P=0.230      (e)          | 
|POLY 6             |     P=0.561      P=0.218N     P=0.543N     P=0.575N    |P=0.524N     P=0.240      P=0.210      (e)          | 
|LOGISTIC REGRESSION|     P=0.554N     P=0.182N     P=0.482N     P=0.471N    |P=0.505N     P=0.240      P=0.175      (e)          | 
|COCH-ARM / FISHERS |     P=0.559N     P=0.187N     P=0.500N     P=0.500N    |P=0.500N     P=0.247      P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.418N     (e)          (e)          (e)         |P=0.264      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 28      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |7/50 (14%)   10/50 (20%)  7/50 (14%)   4/50 (8%)    | 
|POLY-3 RATE (b)    |                                                        |7/45.24      10/45.11     7/44.45      4/43.19      | 
|POLY-3 PERCENT (g) |                                                        |15.5%        22.2%        15.8%        9.3%         | 
|TERMINAL (d)       |                                                        |6/35 (17%)   8/34 (24%)   1/26 (4%)    3/32 (9%)    | 
|FIRST INCIDENCE    |                                                        |606          562          546          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.192N     P=0.279      P=0.478      P=0.312N     | 
|POLY 3             |                                                        |P=0.158N     P=0.293      P=0.600      P=0.288N     | 
|POLY 1.5           |                                                        |P=0.149N     P=0.294      P=0.608      P=0.278N     | 
|POLY 6             |                                                        |P=0.167N     P=0.294      P=0.583      P=0.296N     | 
|LOGISTIC REGRESSION|                                                        |P=0.139N     P=0.292      P=0.581N     P=0.286N     | 
|COCH-ARM / FISHERS |                                                        |P=0.135N     P=0.298      P=0.613N     P=0.262N     | 
|ORDER RESTRICTED   |                                                        |P=0.168N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pancreas: Acinus                                                                                                                 | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    7/48 (15%)   5/50 (10%)   2/50 (4%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/44.48      7/40.75      5/42.07      2/41.38     |1/45.58      1/44.54      1/42.23      0/43.18      | 
|POLY-3 PERCENT (g) |     9.0%         17.2%        11.9%        4.8%        |2.2%         2.3%         2.4%         0.0%         | 
|TERMINAL (d)       |     4/32 (13%)   5/28 (18%)   5/25 (20%)   1/19 (5%)   |0/35 (0%)    1/34 (3%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      618          726 (T)      712         |454          727 (T)      653          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.428N     P=0.196      P=0.344      P=0.588N    |P=0.327N     P=0.757      P=0.745      P=0.504N     | 
|POLY 3             |     P=0.209N     P=0.211      P=0.465      P=0.371N    |P=0.325N     P=0.756      P=0.744      P=0.511N     | 
|POLY 1.5           |     P=0.190N     P=0.220      P=0.473      P=0.353N    |P=0.321N     P=0.757      P=0.752      P=0.507N     | 
|POLY 6             |     P=0.251N     P=0.203      P=0.450      P=0.406N    |P=0.331N     P=0.755      P=0.730      P=0.514N     | 
|LOGISTIC REGRESSION|     P=0.311N     P=0.190      P=0.344      P=0.556N    |P=0.274N     P=0.756N     P=0.738      P=0.402N     | 
|COCH-ARM / FISHERS |     P=0.174N     P=0.239      P=0.500      P=0.339N    |P=0.311N     P=0.753N     P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.170N     (e)          (e)          (e)         |P=0.326N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 29      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    0/50 (0%)    1/50 (2%)   |3/49 (6%)    6/50 (12%)   4/50 (8%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/44.48      1/41.12      0/42.07      1/41.70     |3/44.58      6/44.79      4/42.28      3/43.31      | 
|POLY-3 PERCENT (g) |     2.3%         2.4%         0.0%         2.4%        |6.7%         13.4%        9.5%         6.9%         | 
|TERMINAL (d)       |     1/32 (3%)    1/28 (4%)    0/25 (0%)    0/19 (0%)   |2/34 (6%)    4/34 (12%)   3/26 (12%)   2/32 (6%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          621         |454          665          637          695          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.615      P=0.732      P=0.549N     P=0.704     |P=0.480N     P=0.248      P=0.392      P=0.633      | 
|POLY 3             |     P=0.620N     P=0.743      P=0.511N     P=0.746     |P=0.457N     P=0.244      P=0.471      P=0.649      | 
|POLY 1.5           |     P=0.617N     P=0.748      P=0.508N     P=0.754     |P=0.444N     P=0.246      P=0.490      P=0.656      | 
|POLY 6             |     P=0.625N     P=0.738      P=0.516N     P=0.731     |P=0.469N     P=0.244      P=0.441      P=0.645      | 
|LOGISTIC REGRESSION|     P=0.622N     P=0.732      (e)          P=0.755N    |P=0.435N     P=0.253      P=0.524      P=0.646N     | 
|COCH-ARM / FISHERS |     P=0.614N     P=0.747      P=0.500N     P=0.753N    |P=0.420N     P=0.254      P=0.511      P=0.651N     | 
|ORDER RESTRICTED   |     P=0.539N     (e)          (e)          (e)         |P=0.472      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/49 (2%)    0/50 (0%)    1/50 (2%)   |0/49 (0%)    2/50 (4%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     4/45.19      1/41.28      0/42.07      1/41.33     |0/43.82      2/45.08      2/42.16      3/43.74      | 
|POLY-3 PERCENT (g) |     8.9%         2.4%         0.0%         2.4%        |0.0%         4.4%         4.7%         6.9%         | 
|TERMINAL (d)       |     1/32 (3%)    0/28 (0%)    0/25 (0%)    1/19 (5%)   |0/34 (0%)    0/34 (0%)    1/26 (4%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     554          685          ---          726 (T)     |---          569          674          637          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.169N     P=0.226N     P=0.090N     P=0.316N    |P=0.105      P=0.235      P=0.188      P=0.121      | 
|POLY 3             |     P=0.102N     P=0.207N     P=0.070N     P=0.206N    |P=0.104      P=0.243      P=0.228      P=0.118      | 
|POLY 1.5           |     P=0.101N     P=0.199N     P=0.067N     P=0.192N    |P=0.107      P=0.243      P=0.235      P=0.119      | 
|POLY 6             |     P=0.104N     P=0.217N     P=0.074N     P=0.236N    |P=0.104      P=0.245      P=0.217      P=0.118      | 
|LOGISTIC REGRESSION|     P=0.105N     P=0.177N     P=0.059N     P=0.177N    |P=0.115      P=0.245      P=0.228      P=0.126      | 
|COCH-ARM / FISHERS |     P=0.103N     P=0.187N     P=0.059N     P=0.181N    |P=0.111      P=0.253      P=0.253      P=0.125      | 
|ORDER RESTRICTED   |     P=0.035N*    (e)          (e)          (e)         |P=0.076      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 30      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/50 (16%)   8/49 (16%)   9/50 (18%)   9/50 (18%)  |11/49 (22%)  11/50 (22%)  8/50 (16%)   10/50 (20%)  | 
|POLY-3 RATE (b)    |     8/45.22      8/44.23      9/43.56      9/42.52     |11/45.73     11/45.44     8/42.26      10/44.42     | 
|POLY-3 PERCENT (g) |     17.7%        18.1%        20.7%        21.2%       |24.1%        24.2%        18.9%        22.5%        | 
|TERMINAL (d)       |     7/32 (22%)   3/28 (11%)   5/25 (20%)   4/19 (21%)  |8/34 (24%)   9/34 (27%)   7/26 (27%)   6/32 (19%)   | 
|FIRST INCIDENCE    |     468          338          539          623         |370          356          642          398          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.180      P=0.527      P=0.335      P=0.188     |P=0.492N     P=0.593N     P=0.515N     P=0.552N     | 
|POLY 3             |     P=0.366      P=0.589      P=0.466      P=0.444     |P=0.441N     P=0.590      P=0.373N     P=0.530N     | 
|POLY 1.5           |     P=0.397      P=0.589      P=0.470      P=0.472     |P=0.423N     P=0.592N     P=0.334N     P=0.514N     | 
|POLY 6             |     P=0.313      P=0.591      P=0.459      P=0.393     |P=0.457N     P=0.583      P=0.432N     P=0.539N     | 
|LOGISTIC REGRESSION|     P=0.447      P=0.514N     P=0.491      P=0.469     |P=0.390N     P=0.570N     P=0.285N     P=0.453N     | 
|COCH-ARM / FISHERS |     P=0.431      P=0.590      P=0.500      P=0.500     |P=0.389N     P=0.574N     P=0.288N     P=0.479N     | 
|ORDER RESTRICTED   |     P=0.534      (e)          (e)          (e)         |P=0.549N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |12/50 (24%)  7/50 (14%)   4/50 (8%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     3/44.95      0/41.12      0/42.07      0/41.33     |12/45.75     7/44.56      4/42.01      5/43.94      | 
|POLY-3 PERCENT (g) |     6.7%         0.0%         0.0%         0.0%        |26.2%        15.7%        9.5%         11.4%        | 
|TERMINAL (d)       |     2/32 (6%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |8/35 (23%)   6/34 (18%)   2/26 (8%)    4/32 (13%)   | 
|FIRST INCIDENCE    |     588          ---          ---          ---         |606          722          714          454          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.066N     P=0.140N     P=0.158N     P=0.186N    |P=0.065N     P=0.176N     P=0.093N     P=0.084N     | 
|POLY 3             |     P=0.042N*    P=0.135N     P=0.131N     P=0.134N    |P=0.040N*    P=0.166N     P=0.038N*    P=0.062N     | 
|POLY 1.5           |     P=0.043N*    P=0.130N     P=0.128N     P=0.126N    |P=0.038N*    P=0.161N     P=0.031N*    P=0.058N     | 
|POLY 6             |     P=0.041N*    P=0.141N     P=0.136N     P=0.151N    |P=0.043N*    P=0.172N     P=0.052N     P=0.066N     | 
|LOGISTIC REGRESSION|     P=0.047N*    P=0.120N     P=0.119N     P=0.116N    |P=0.044N*    P=0.155N     P=0.043N*    P=0.058N     | 
|COCH-ARM / FISHERS |     P=0.047N*    P=0.125N     P=0.121N     P=0.121N    |P=0.037N*    P=0.154N     P=0.027N*    P=0.054N     | 
|ORDER RESTRICTED   |     P=0.011N*    (e)          (e)          (e)         |P=0.025N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 31      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pleura                                                                                                                           | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   0/49 (0%)    6/50 (12%)   4/50 (8%)   |7/50 (14%)   7/50 (14%)   1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/44.95      0/41.12      6/43.07      4/41.98     |7/45.68      7/45.14      1/41.95      1/43.31      | 
|POLY-3 PERCENT (g) |     13.4%        0.0%         13.9%        9.5%        |15.3%        15.5%        2.4%         2.3%         | 
|TERMINAL (d)       |     5/32 (16%)   0/28 (0%)    5/25 (20%)   1/19 (5%)   |4/35 (11%)   5/34 (15%)   1/26 (4%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     588          ---          57           652         |606          562          727 (T)      695          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.335      P=0.025N*    P=0.467      P=0.622N    |P=0.013N*    P=0.591      P=0.068N     P=0.046N*    | 
|POLY 3             |     P=0.555      P=0.020N*    P=0.591      P=0.413N    |P=0.007N**   P=0.604      P=0.040N*    P=0.036N*    | 
|POLY 1.5           |     P=0.570      P=0.019N*    P=0.602      P=0.390N    |P=0.007N**   P=0.607      P=0.035N*    P=0.034N*    | 
|POLY 6             |     P=0.521      P=0.022N*    P=0.571      P=0.456N    |P=0.008N**   P=0.602      P=0.049N*    P=0.038N*    | 
|LOGISTIC REGRESSION|     P=0.556N     P=0.022N*    P=0.583N     P=0.402N    |P=0.008N**   P=0.612      P=0.035N*    P=0.033N*    | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.014N*    P=0.620N     P=0.370N    |P=0.007N**   P=0.613N     P=0.030N*    P=0.030N*    | 
|ORDER RESTRICTED   |     P=0.299N     (e)          (e)          (e)         |P=0.018N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     1/44.48      2/41.57      0/42.07      0/41.33     |                                                    | 
|POLY-3 PERCENT (g) |     2.3%         4.8%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     1/32 (3%)    1/28 (4%)    0/25 (0%)    0/19 (0%)   |                                                    | 
|FIRST INCIDENCE    |     726 (T)      595          ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240N     P=0.472      P=0.549N     P=0.604N    |                                                    | 
|POLY 3             |     P=0.199N     P=0.476      P=0.511N     P=0.515N    |                                                    | 
|POLY 1.5           |     P=0.194N     P=0.482      P=0.508N     P=0.507N    |                                                    | 
|POLY 6             |     P=0.209N     P=0.471      P=0.516N     P=0.530N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.189N     P=0.494      (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.187N     P=0.492      P=0.500N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.169N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 32      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Preputial Gland                                                                                                                  | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/49 (4%)    0/50 (0%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     1/44.48      2/41.49      0/42.07      3/41.95     |                                                    | 
|POLY-3 PERCENT (g) |     2.3%         4.8%         0.0%         7.2%        |                                                    | 
|TERMINAL (d)       |     1/32 (3%)    1/28 (4%)    0/25 (0%)    1/19 (5%)   |                                                    | 
|FIRST INCIDENCE    |     726 (T)      621          ---          621         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.166      P=0.458      P=0.549N     P=0.200     |                                                    | 
|POLY 3             |     P=0.229      P=0.476      P=0.511N     P=0.284     |                                                    | 
|POLY 1.5           |     P=0.237      P=0.482      P=0.508N     P=0.295     |                                                    | 
|POLY 6             |     P=0.215      P=0.470      P=0.516N     P=0.262     |                                                    | 
|LOGISTIC REGRESSION|     P=0.243      P=0.485      (e)          P=0.306     |                                                    | 
|COCH-ARM / FISHERS |     P=0.244      P=0.492      P=0.500N     P=0.309     |                                                    | 
|ORDER RESTRICTED   |     P=0.165      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Prostate                                                                                                                         | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/49 (2%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     3/44.96      1/41.57      0/42.07      2/41.54     |                                                    | 
|POLY-3 PERCENT (g) |     6.7%         2.4%         0.0%         4.8%        |                                                    | 
|TERMINAL (d)       |     1/32 (3%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |                                                    | 
|FIRST INCIDENCE    |     588          595          ---          694         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.542N     P=0.335N     P=0.161N     P=0.656N    |                                                    | 
|POLY 3             |     P=0.447N     P=0.334N     P=0.131N     P=0.536N    |                                                    | 
|POLY 1.5           |     P=0.444N     P=0.326N     P=0.128N     P=0.517N    |                                                    | 
|POLY 6             |     P=0.453N     P=0.342N     P=0.137N     P=0.571N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.439N     P=0.281N     P=0.118N     P=0.505N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.442N     P=0.316N     P=0.121N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.218N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 33      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Cyst Epithelial Inclusion                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    3/49 (6%)    0/50 (0%)    4/50 (8%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/44.48      3/41.37      0/42.07      4/41.41     |1/44.87      1/44.54      0/41.95      1/43.18      | 
|POLY-3 PERCENT (g) |     6.7%         7.3%         0.0%         9.7%        |2.2%         2.3%         0.0%         2.3%         | 
|TERMINAL (d)       |     3/32 (9%)    2/28 (7%)    0/25 (0%)    3/19 (16%)  |0/35 (0%)    1/34 (3%)    0/26 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     726 (T)      658          ---          705         |714          727 (T)      ---          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.245      P=0.600      P=0.167N     P=0.241     |P=0.642N     P=0.757      P=0.549N     P=0.741      | 
|POLY 3             |     P=0.437      P=0.629      P=0.129N     P=0.461     |P=0.623N     P=0.759      P=0.513N     P=0.752      | 
|POLY 1.5           |     P=0.448      P=0.637      P=0.126N     P=0.481     |P=0.619N     P=0.759      P=0.507N     P=0.755      | 
|POLY 6             |     P=0.413      P=0.620      P=0.133N     P=0.421     |P=0.629N     P=0.759      P=0.525N     P=0.750      | 
|LOGISTIC REGRESSION|     P=0.328      P=0.611      (e)          P=0.270     |P=0.635N     P=0.762      P=0.528N     P=0.752      | 
|COCH-ARM / FISHERS |     P=0.460      P=0.651      P=0.121N     P=0.500     |P=0.616N     P=0.753N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.257      (e)          (e)          (e)         |P=0.550N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/49 (2%)    1/50 (2%)    3/50 (6%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/45.15      1/41.12      1/42.07      3/41.48     |1/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     2.2%         2.4%         2.4%         7.2%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    1/28 (4%)    1/25 (4%)    1/19 (5%)   |1/35 (3%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     505          726 (T)      726 (T)      694         |727 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.087      P=0.741      P=0.733      P=0.198     |P=0.325N     P=0.506N     P=0.559N     P=0.518N     | 
|POLY 3             |     P=0.151      P=0.740      P=0.745      P=0.275     |P=0.306N     P=0.501N     P=0.513N     P=0.507N     | 
|POLY 1.5           |     P=0.159      P=0.746      P=0.749      P=0.290     |P=0.305N     P=0.501N     P=0.506N     P=0.505N     | 
|POLY 6             |     P=0.137      P=0.733      P=0.738      P=0.249     |P=0.309N     P=0.501N     P=0.525N     P=0.509N     | 
|LOGISTIC REGRESSION|     P=0.163      P=0.722N     P=0.730N     P=0.324     |P=0.325N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.165      P=0.747      P=0.753N     P=0.309     |P=0.306N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.157      (e)          (e)          (e)         |P=0.127N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 34      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Acute                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/49 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.48      1/41.12      0/42.07      0/41.33     |0/44.82      2/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         2.4%         0.0%         0.0%        |0.0%         4.5%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    1/28 (4%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    2/34 (6%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          726 (T)      ---          ---         |---          727 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.645N     P=0.473      (e)          (e)         |P=0.431N     P=0.232      (e)          (e)          | 
|POLY 3             |     P=0.579N     P=0.484      (e)          (e)         |P=0.416N     P=0.236      (e)          (e)          | 
|POLY 1.5           |     P=0.574N     P=0.488      (e)          (e)         |P=0.411N     P=0.236      (e)          (e)          | 
|POLY 6             |     P=0.585N     P=0.479      (e)          (e)         |P=0.422N     P=0.236      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.473      (e)          (e)         |(e)          P=0.232      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.566N     P=0.495      (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.380N     (e)          (e)          (e)         |P=0.254N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Granulomatous                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.48      0/41.12      1/42.22      2/41.33     |0/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         4.8%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    2/19 (11%)  |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          688          726 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.035 *    (e)          P=0.489      P=0.132     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.065      (e)          P=0.490      P=0.221     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.069      (e)          P=0.492      P=0.229     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.058      (e)          P=0.486      P=0.205     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.049 *    (e)          P=0.496      P=0.132     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.071      (e)          P=0.500      P=0.247     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.064      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 35      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/44.48      0/41.12      0/42.07      0/41.33     |1/44.89      1/44.99      0/41.95      2/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |2.2%         2.2%         0.0%         4.6%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    2/32 (6%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |709          594          ---          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.340      P=0.758      P=0.554N     P=0.466      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.355      P=0.760N     P=0.514N     P=0.486      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.360      P=0.760N     P=0.507N     P=0.491      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.348      P=0.759N     P=0.525N     P=0.483      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.364      P=0.759N     P=0.521N     P=0.482      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.366      P=0.753N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.260      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Accessory Spleen                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     2/45.17      1/41.74      0/42.07      1/41.78     |0/44.82      0/44.54      1/41.95      1/43.18      | 
|POLY-3 PERCENT (g) |     4.4%         2.4%         0.0%         2.4%        |0.0%         0.0%         2.4%         2.3%         | 
|TERMINAL (d)       |     1/32 (3%)    1/28 (4%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    1/26 (4%)    1/32 (3%)    | 
|FIRST INCIDENCE    |     492          726 (T)      ---          595         |---          ---          727 (T)      727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.429N     P=0.538N     P=0.269N     P=0.549N    |P=0.222      (e)          P=0.441      P=0.482      | 
|POLY 3             |     P=0.371N     P=0.527N     P=0.253N     P=0.527N    |P=0.227      (e)          P=0.487      P=0.493      | 
|POLY 1.5           |     P=0.369N     P=0.517N     P=0.249N     P=0.513N    |P=0.230      (e)          P=0.494      P=0.495      | 
|POLY 6             |     P=0.375N     P=0.540N     P=0.260N     P=0.553N    |P=0.226      (e)          P=0.475      P=0.491      | 
|LOGISTIC REGRESSION|     P=0.355N     P=0.459N     P=0.183N     P=0.516N    |(e)          (e)          P=0.441      P=0.482      | 
|COCH-ARM / FISHERS |     P=0.366N     P=0.500N     P=0.247N     P=0.500N    |P=0.236      (e)          P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.252N     (e)          (e)          (e)         |P=0.238      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 36      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    5/50 (10%)   3/50 (6%)    8/50 (16%)  |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/45.30      5/42.75      3/42.13      8/42.18     |0/44.82      1/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     4.4%         11.7%        7.1%         19.0%       |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    3/28 (11%)   2/25 (8%)    3/19 (16%)  |0/35 (0%)    1/34 (3%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     588          420          713          609         |---          727 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.010 *    P=0.183      P=0.427      P=0.017 *   |P=0.583N     P=0.494      (e)          (e)          | 
|POLY 3             |     P=0.029 *    P=0.193      P=0.467      P=0.033 *   |P=0.574N     P=0.499      (e)          (e)          | 
|POLY 1.5           |     P=0.034 *    P=0.202      P=0.476      P=0.039 *   |P=0.571N     P=0.499      (e)          (e)          | 
|POLY 6             |     P=0.022 *    P=0.180      P=0.451      P=0.025 *   |P=0.579N     P=0.499      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.039 *    P=0.269      P=0.505      P=0.050     |(e)          P=0.494      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.040 *    P=0.218      P=0.500      P=0.046 *   |P=0.567N     P=0.500      (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.016 *    (e)          (e)          (e)         |P=0.386N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/44.93      2/42.20      2/42.45      1/41.60     |1/45.30      0/44.54      1/42.05      0/43.18      | 
|POLY-3 PERCENT (g) |     4.5%         4.7%         4.7%         2.4%        |2.2%         0.0%         2.4%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    1/25 (4%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     629          602          619          652         |583          ---          702          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.458N     P=0.658      P=0.649      P=0.579N    |P=0.430N     P=0.509N     P=0.726      P=0.513N     | 
|POLY 3             |     P=0.398N     P=0.671      P=0.674      P=0.527N    |P=0.412N     P=0.503N     P=0.744      P=0.510N     | 
|POLY 1.5           |     P=0.385N     P=0.680      P=0.678      P=0.513N    |P=0.410N     P=0.502N     P=0.752      P=0.506N     | 
|POLY 6             |     P=0.425N     P=0.661      P=0.665      P=0.554N    |P=0.415N     P=0.504N     P=0.730      P=0.513N     | 
|LOGISTIC REGRESSION|     P=0.366N     P=0.675N     P=0.687N     P=0.481N    |P=0.385N     P=0.488N     P=0.755N     P=0.458N     | 
|COCH-ARM / FISHERS |     P=0.373N     P=0.691N     P=0.691N     P=0.500N    |P=0.405N     P=0.500N     P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.475N     (e)          (e)          (e)         |P=0.260N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 37      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    6/50 (12%)   4/50 (8%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     4/45.82      4/42.30      6/43.55      4/42.12     |1/44.90      0/44.54      0/41.95      1/43.20      | 
|POLY-3 PERCENT (g) |     8.7%         9.5%         13.8%        9.5%        |2.2%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     468          659          539          649         |707          ---          ---          723          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.374      P=0.564      P=0.330      P=0.496     |P=0.570      P=0.495N     P=0.559N     P=0.742      | 
|POLY 3             |     P=0.482      P=0.599      P=0.338      P=0.597     |P=0.588      P=0.502N     P=0.514N     P=0.752      | 
|POLY 1.5           |     P=0.509      P=0.615      P=0.344      P=0.620     |P=0.591      P=0.501N     P=0.507N     P=0.755      | 
|POLY 6             |     P=0.430      P=0.580      P=0.328      P=0.555     |P=0.585      P=0.502N     P=0.525N     P=0.750      | 
|LOGISTIC REGRESSION|     P=0.546      P=0.596N     P=0.432      P=0.609N    |P=0.582      P=0.501N     P=0.518N     P=0.753      | 
|COCH-ARM / FISHERS |     P=0.533      P=0.643N     P=0.370      P=0.643N    |P=0.595      P=0.500N     P=0.500N     P=0.753N     | 
|ORDER RESTRICTED   |     P=0.512      (e)          (e)          (e)         |P=0.392      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/48 (0%)    1/50 (2%)    1/50 (2%)   |0/50 (0%)    2/50 (4%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.48      0/40.28      1/42.17      1/42.00     |0/44.82      2/44.65      2/42.44      0/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         2.4%         2.4%        |0.0%         4.5%         4.7%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          702          498         |---          707          616          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.209      (e)          P=0.470      P=0.508     |P=0.533N     P=0.249      P=0.206      (e)          | 
|POLY 3             |     P=0.229      (e)          P=0.489      P=0.489     |P=0.518N     P=0.236      P=0.225      (e)          | 
|POLY 1.5           |     P=0.236      (e)          P=0.492      P=0.495     |P=0.512N     P=0.236      P=0.231      (e)          | 
|POLY 6             |     P=0.212      (e)          P=0.485      P=0.475     |P=0.523N     P=0.237      P=0.215      (e)          | 
|LOGISTIC REGRESSION|     P=0.234      (e)          P=0.490      P=0.249     |P=0.500N     P=0.236      P=0.246      (e)          | 
|COCH-ARM / FISHERS |     P=0.239      (e)          P=0.500      P=0.500     |P=0.500N     P=0.247      P=0.247      (e)          | 
|ORDER RESTRICTED   |     P=0.240      (e)          (e)          (e)         |P=0.265      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 38      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/48 (2%)    6/50 (12%)   6/50 (12%)  |2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/45.16      1/40.28      6/43.21      6/43.40     |2/44.87      0/44.54      1/42.26      1/43.19      | 
|POLY-3 PERCENT (g) |     6.6%         2.5%         13.9%        13.8%       |4.5%         0.0%         2.4%         2.3%         | 
|TERMINAL (d)       |     0/32 (0%)    1/28 (4%)    0/25 (0%)    0/19 (0%)   |1/35 (3%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     588          726 (T)      637          498         |714          ---          642          726          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.042 *    P=0.354N     P=0.203      P=0.162     |P=0.525N     P=0.243N     P=0.576N     P=0.527N     | 
|POLY 3             |     P=0.078      P=0.347N     P=0.220      P=0.222     |P=0.508N     P=0.239N     P=0.521N     P=0.513N     | 
|POLY 1.5           |     P=0.082      P=0.337N     P=0.224      P=0.234     |P=0.504N     P=0.238N     P=0.510N     P=0.509N     | 
|POLY 6             |     P=0.067      P=0.360N     P=0.214      P=0.196     |P=0.512N     P=0.239N     P=0.539N     P=0.517N     | 
|LOGISTIC REGRESSION|     P=0.086      P=0.313N     P=0.251      P=0.268     |P=0.510N     P=0.238N     P=0.509N     P=0.519N     | 
|COCH-ARM / FISHERS |     P=0.083      P=0.324N     P=0.243      P=0.243     |P=0.500N     P=0.247N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.098      (e)          (e)          (e)         |P=0.285N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Glandular                                                                                                               | 
|     Erosion                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/48 (2%)    2/50 (4%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.83      1/41.08      2/42.98      3/42.21     |0/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     2.2%         2.4%         4.7%         7.1%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     629          420          544          638         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.157      P=0.745      P=0.492      P=0.266     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.156      P=0.741      P=0.485      P=0.284     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.164      P=0.745      P=0.488      P=0.295     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.141      P=0.736      P=0.480      P=0.262     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.165      P=0.630N     P=0.579      P=0.322     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.169      P=0.742      P=0.500      P=0.309     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.194      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 39      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     10/50 (20%)  8/50 (16%)   8/50 (16%)   15/50 (30%) |                                                    | 
|POLY-3 RATE (b)    |     10/45.22     8/42.57      8/43.17      15/44.17    |                                                    | 
|POLY-3 PERCENT (g) |     22.1%        18.8%        18.5%        34.0%       |                                                    | 
|TERMINAL (d)       |     5/32 (16%)   4/28 (14%)   3/25 (12%)   4/19 (21%)  |                                                    | 
|FIRST INCIDENCE    |     671          637          633          567         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.018 *    P=0.538N     P=0.555N     P=0.039 *   |                                                    | 
|POLY 3             |     P=0.083      P=0.452N     P=0.439N     P=0.153     |                                                    | 
|POLY 1.5           |     P=0.088      P=0.432N     P=0.431N     P=0.167     |                                                    | 
|POLY 6             |     P=0.071      P=0.477N     P=0.454N     P=0.127     |                                                    | 
|LOGISTIC REGRESSION|     P=0.080      P=0.455N     P=0.437N     P=0.169     |                                                    | 
|COCH-ARM / FISHERS |     P=0.091      P=0.398N     P=0.398N     P=0.178     |                                                    | 
|ORDER RESTRICTED   |     P=0.081      (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Interstitial Cell                                                                                                        | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/50 (6%)    1/50 (2%)    3/50 (6%)   |                                                    | 
|POLY-3 RATE (b)    |     4/45.78      3/42.95      1/42.56      3/42.45     |                                                    | 
|POLY-3 PERCENT (g) |     8.7%         7.0%         2.4%         7.1%        |                                                    | 
|TERMINAL (d)       |     1/32 (3%)    1/28 (4%)    0/25 (0%)    0/19 (0%)   |                                                    | 
|FIRST INCIDENCE    |     468          405          580          544         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.470N     P=0.543N     P=0.220N     P=0.598N    |                                                    | 
|POLY 3             |     P=0.418N     P=0.535N     P=0.201N     P=0.541N    |                                                    | 
|POLY 1.5           |     P=0.408N     P=0.521N     P=0.195N     P=0.521N    |                                                    | 
|POLY 6             |     P=0.439N     P=0.551N     P=0.211N     P=0.579N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.375N     P=0.350N     P=0.118N     P=0.480N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.397N     P=0.500N     P=0.181N     P=0.500N    |                                                    | 
|ORDER RESTRICTED   |     P=0.346N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 40      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: C-Cell                                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    3/48 (6%)    5/50 (10%)   1/50 (2%)   |4/50 (8%)    2/50 (4%)    2/50 (4%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     4/44.73      3/40.28      5/42.74      1/41.33     |4/44.82      2/44.54      2/42.44      5/44.06      | 
|POLY-3 PERCENT (g) |     8.9%         7.5%         11.7%        2.4%        |8.9%         4.5%         4.7%         11.4%        | 
|TERMINAL (d)       |     2/32 (6%)    3/28 (11%)   1/25 (4%)    1/19 (5%)   |4/35 (11%)   2/34 (6%)    1/26 (4%)    3/32 (9%)    | 
|FIRST INCIDENCE    |     687          726 (T)      637          726 (T)     |727 (T)      727 (T)      582          454          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.358N     P=0.580N     P=0.401      P=0.346N    |P=0.283      P=0.349N     P=0.458N     P=0.448      | 
|POLY 3             |     P=0.201N     P=0.557N     P=0.471      P=0.203N    |P=0.321      P=0.340N     P=0.362N     P=0.489      | 
|POLY 1.5           |     P=0.185N     P=0.544N     P=0.477      P=0.190N    |P=0.325      P=0.339N     P=0.349N     P=0.492      | 
|POLY 6             |     P=0.236N     P=0.572N     P=0.462      P=0.230N    |P=0.317      P=0.339N     P=0.386N     P=0.489      | 
|LOGISTIC REGRESSION|     P=0.221N     P=0.575N     P=0.472      P=0.254N    |P=0.325      P=0.349N     P=0.365N     P=0.494      | 
|COCH-ARM / FISHERS |     P=0.174N     P=0.523N     P=0.500      P=0.181N    |P=0.331      P=0.339N     P=0.339N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.171N     (e)          (e)          (e)         |P=0.270      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Tongue: Epithelium                                                                                                               | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/1 (100%)   1/1 (100%)   0/0 (0%)     0/0 (0%)    |1/1 (100%)   1/1 (100%)   3/3 (100%)   2/2 (100%)   | 
|POLY-3 RATE (b)    |     1/1.00       1/1.00       0/0.00       0/0.00      |1/1.00       1/1.00       3/3.00       2/2.00       | 
|POLY-3 PERCENT (g) |     100.0%       100.0%       0.0%         0.0%        |100.0%       100.0%       100.0%       100.0%       | 
|TERMINAL (d)       |     1/1 (100%)   1/1 (100%)   0/0 (0%)     0/0 (0%)    |1/1 (100%)   1/1 (100%)   1/1 (100%)   1/1 (100%)   | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      ---          ---         |727 (T)      727 (T)      621          651          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 41      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Trachea                                                                                                                          | 
|     Inflammation                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/48 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/44.48      2/41.43      0/42.07      0/41.33     |0/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     0.0%         4.8%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/32 (0%)    0/28 (0%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     ---          338          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430N     P=0.226      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.422N     P=0.221      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.413N     P=0.224      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.438N     P=0.218      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.373N     P=0.409      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.403N     P=0.237      (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.248N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Urinary Bladder                                                                                                                  | 
|     Calculus Micro Observation Only                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/48 (4%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/44.48      2/40.28      2/42.91      0/41.33     |0/44.82      0/44.54      0/41.95      0/43.18      | 
|POLY-3 PERCENT (g) |     2.3%         5.0%         4.7%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/32 (3%)    2/28 (7%)    0/25 (0%)    0/19 (0%)   |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |     726 (T)      726 (T)      539          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.396N     P=0.453      P=0.466      P=0.604N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.319N     P=0.465      P=0.487      P=0.515N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.305N     P=0.473      P=0.489      P=0.507N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.347N     P=0.458      P=0.483      P=0.530N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.291N     P=0.453      P=0.537      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.293N     P=0.485      P=0.500      P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.223N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 42      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemorrhage                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |                                                        |1/45.69      0/44.54      1/42.14      2/44.14      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         0.0%         2.4%         4.5%         | 
|TERMINAL (d)       |                                                        |0/35 (0%)    0/34 (0%)    0/26 (0%)    0/32 (0%)    | 
|FIRST INCIDENCE    |                                                        |370          ---          677          398          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.239      P=0.504N     P=0.733      P=0.486      | 
|POLY 3             |                                                        |P=0.242      P=0.505N     P=0.742      P=0.488      | 
|POLY 1.5           |                                                        |P=0.244      P=0.504N     P=0.751      P=0.492      | 
|POLY 6             |                                                        |P=0.240      P=0.506N     P=0.729      P=0.486      | 
|LOGISTIC REGRESSION|                                                        |P=0.336      P=0.434N     P=0.713      P=0.662      | 
|COCH-ARM / FISHERS |                                                        |P=0.247      P=0.500N     P=0.753N     P=0.500      | 
|ORDER RESTRICTED   |                                                        |P=0.215      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/44.82      0/44.54      0/41.95      1/43.18      | 
|POLY-3 PERCENT (g) |                                                        |4.5%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |                                                        |2/35 (6%)    0/34 (0%)    0/26 (0%)    1/32 (3%)    | 
|FIRST INCIDENCE    |                                                        |727 (T)      ---          ---          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.492N     P=0.245N     P=0.306N     P=0.531N     | 
|POLY 3             |                                                        |P=0.464N     P=0.238N     P=0.252N     P=0.513N     | 
|POLY 1.5           |                                                        |P=0.462N     P=0.238N     P=0.244N     P=0.509N     | 
|POLY 6             |                                                        |P=0.470N     P=0.238N     P=0.265N     P=0.516N     | 
|LOGISTIC REGRESSION|                                                        |P=0.492N     (e)          (e)          P=0.531N     | 
|COCH-ARM / FISHERS |                                                        |P=0.461N     P=0.247N     P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.140N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  05/11/04                           EXPERIMENT: 97006 TEST: 01                                            Page 43      
Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  METHYL ISOBUTYL KETONE                
                                         Terminal Sacrifice at 104 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    2/50 (4%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.82      2/44.54      3/42.05      3/43.18      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         4.5%         7.1%         7.0%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    2/34 (6%)    2/26 (8%)    3/32 (9%)    | 
|FIRST INCIDENCE    |                                                        |727 (T)      727 (T)      702          727 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.190      P=0.490      P=0.210      P=0.273      | 
|POLY 3             |                                                        |P=0.210      P=0.498      P=0.282      P=0.292      | 
|POLY 1.5           |                                                        |P=0.217      P=0.498      P=0.294      P=0.296      | 
|POLY 6             |                                                        |P=0.205      P=0.498      P=0.264      P=0.288      | 
|LOGISTIC REGRESSION|                                                        |P=0.197      P=0.490      P=0.235      P=0.273      | 
|COCH-ARM / FISHERS |                                                        |P=0.227      P=0.500      P=0.309      P=0.309      | 
|ORDER RESTRICTED   |                                                        |P=0.244      (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.