National Toxicology Program

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TDMS Study 97006-02 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                  METHYL ISOBUTYL KETONE                                DATE: 04/29/04       
EXPERIMENT: 97006 TEST: 02                                                                                     TIME: 07:49:21       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05452                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C97006       
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 108-10-1        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                  METHYL ISOBUTYL KETONE                                DATE: 04/29/04       
EXPERIMENT: 97006 TEST: 02                                                                                     TIME: 07:49:21       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05452                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C97006       
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 108-10-1        
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Brain                                                                              
                                                 Heart                                                                              
                                                 Islets, Pancreatic                                                                 
                                                 Kidney                                                                             
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Ovary                                                                              
                                                 Parathyroid Gland                                                                  
                                                 Pituitary Gland                                                                    
                                                 Salivary Glands                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thymus                                                                             
                                                 Thyroid Gland                                                                      
                                                                                                                                   
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                  METHYL ISOBUTYL KETONE                                DATE: 04/29/04       
EXPERIMENT: 97006 TEST: 02                                                                                     TIME: 07:49:21       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05452                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C97006       
PATHOLOGIST: GRUMBEIN, SONDRA                                                                                  CAS: 108-10-1        
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF                 METHYL ISOBUTYL KETONE                                                                           
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
                                       Hepatocholangiocarcinoma                                                                     
Lung                                   Alveolar/Bronchiolar Adenoma                                                                 
                                       Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
Stomach, Forestomach                   Squamous Cell Carcinoma or Papilloma Squamous                                                
All Organs                             Benign Tumors                                                                                
                                       Malignant Tumors                                                                             
                                       Malignant and Benign Tumors                                                                  
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Hepatocellular Adenoma                                                                       
                                       Hepatocellular Carcinoma or Hepatocellular Adenoma                                           
                                       Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                          
Uterus                                 Sarcoma Stromal or Polyp Stromal                                                             
All Organs                             Histiocytic Sarcoma                                                                          
                                       Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type      
===============================================================                                                                     
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -                  METHYL ISOBUTYL KETONE        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/49 (2%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/46.53      0/47.50      1/41.96      1/45.34     |0/44.99      0/45.87      0/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     4.3%         0.0%         2.4%         2.2%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    0/42 (0%)    0/35 (0%)    1/37 (3%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          698          729 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.529N     P=0.228N     P=0.540N     P=0.527N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.513N     P=0.233N     P=0.536N     P=0.509N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.509N     P=0.235N     P=0.529N     P=0.506N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.518N     P=0.229N     P=0.540N     P=0.512N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.518N     (e)          P=0.540N     P=0.527N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.501N     P=0.247N     P=0.508N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.283N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma Benign                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/47.50      0/41.84      0/45.34     |2/44.99      0/45.87      0/44.87      1/45.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |2/35 (6%)    0/37 (0%)    0/38 (0%)    1/37 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.449N     P=0.226N     P=0.220N     P=0.481N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.469N     P=0.233N     P=0.238N     P=0.496N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.468N     P=0.235N     P=0.239N     P=0.500N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.470N     P=0.232N     P=0.236N     P=0.491N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.449N     (e)          (e)          P=0.481N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.467N     P=0.247N     P=0.253N     P=0.508N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.129N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     1/46.53      0/47.50      0/41.84      0/45.34     |2/44.99      0/45.87      0/44.87      1/45.46      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |2/35 (6%)    0/37 (0%)    0/38 (0%)    1/37 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |731 (T)      ---          ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.320N     P=0.490N     P=0.527N     P=0.516N    |P=0.449N     P=0.226N     P=0.220N     P=0.481N     | 
|POLY 3             |     P=0.312N     P=0.496N     P=0.521N     P=0.505N    |P=0.469N     P=0.233N     P=0.238N     P=0.496N     | 
|POLY 1.5           |     P=0.310N     P=0.498N     P=0.517N     P=0.503N    |P=0.468N     P=0.235N     P=0.239N     P=0.500N     | 
|POLY 6             |     P=0.313N     P=0.493N     P=0.524N     P=0.507N    |P=0.470N     P=0.232N     P=0.236N     P=0.491N     | 
|LOGISTIC REGRESSION|     P=0.320N     (e)          (e)          (e)         |P=0.449N     (e)          (e)          P=0.481N     | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.505N     P=0.500N    |P=0.467N     P=0.247N     P=0.253N     P=0.508N     | 
|ORDER RESTRICTED   |     P=0.125N     (e)          (e)          (e)         |P=0.129N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    5/50 (10%)   7/50 (14%)  |6/50 (12%)   4/50 (8%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     5/46.97      4/47.50      5/42.99      7/46.37     |6/45.54      4/45.87      2/46.02      3/47.37      | 
|POLY-3 PERCENT (g) |     10.6%        8.4%         11.6%        15.1%       |13.2%        8.7%         4.4%         6.3%         | 
|TERMINAL (d)       |     4/40 (10%)   4/42 (10%)   4/35 (11%)   5/37 (14%)  |4/35 (11%)   4/37 (11%)   1/39 (3%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     598          729 (T)      480          551         |586          731 (T)      695          329          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.203      P=0.476N     P=0.546      P=0.335     |P=0.148N     P=0.339N     P=0.117N     P=0.214N     | 
|POLY 3             |     P=0.238      P=0.493N     P=0.574      P=0.370     |P=0.160N     P=0.365N     P=0.129N     P=0.223N     | 
|POLY 1.5           |     P=0.244      P=0.496N     P=0.589      P=0.373     |P=0.163N     P=0.367N     P=0.131N     P=0.228N     | 
|POLY 6             |     P=0.233      P=0.487N     P=0.561      P=0.368     |P=0.155N     P=0.367N     P=0.128N     P=0.217N     | 
|LOGISTIC REGRESSION|     P=0.256      P=0.495N     P=0.629      P=0.403     |P=0.174N     P=0.360N     P=0.132N     P=0.265N     | 
|COCH-ARM / FISHERS |     P=0.254      P=0.500N     P=0.630N     P=0.380     |P=0.170N     P=0.370N     P=0.134N     P=0.243N     | 
|ORDER RESTRICTED   |     P=0.314      (e)          (e)          (e)         |P=0.130N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     2/46.53      1/47.50      1/42.28      2/45.34     |1/45.05      3/45.87      2/46.18      3/46.46      | 
|POLY-3 PERCENT (g) |     4.3%         2.1%         2.4%         4.4%        |2.2%         6.5%         4.3%         6.5%         | 
|TERMINAL (d)       |     2/40 (5%)    1/42 (2%)    1/35 (3%)    2/37 (5%)   |0/35 (0%)    3/37 (8%)    1/39 (3%)    3/38 (8%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      729 (T)     |715          731 (T)      648          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.515      P=0.483N     P=0.547N     P=0.667     |P=0.332      P=0.324      P=0.521      P=0.338      | 
|POLY 3             |     P=0.539      P=0.493N     P=0.533N     P=0.685     |P=0.317      P=0.312      P=0.509      P=0.316      | 
|POLY 1.5           |     P=0.545      P=0.496N     P=0.524N     P=0.688     |P=0.312      P=0.309      P=0.505      P=0.313      | 
|POLY 6             |     P=0.533      P=0.487N     P=0.540N     P=0.682     |P=0.324      P=0.312      P=0.512      P=0.322      | 
|LOGISTIC REGRESSION|     P=0.515      P=0.483N     P=0.547N     P=0.667     |P=0.315      P=0.314      P=0.500      P=0.329      | 
|COCH-ARM / FISHERS |     P=0.556      P=0.500N     P=0.500N     P=0.691N    |P=0.302      P=0.309      P=0.500      P=0.309      | 
|ORDER RESTRICTED   |     P=0.543      (e)          (e)          (e)         |P=0.279      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   5/50 (10%)   6/50 (12%)   8/50 (16%)  |7/50 (14%)   7/50 (14%)   4/50 (8%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     7/46.97      5/47.50      6/42.99      8/46.37     |7/45.60      7/45.87      4/46.32      6/47.37      | 
|POLY-3 PERCENT (g) |     14.9%        10.5%        14.0%        17.3%       |15.4%        15.3%        8.6%         12.7%        | 
|TERMINAL (d)       |     6/40 (15%)   5/42 (12%)   5/35 (14%)   6/37 (16%)  |4/35 (11%)   7/37 (19%)   2/39 (5%)    5/38 (13%)   | 
|FIRST INCIDENCE    |     598          729 (T)      480          551         |586          731 (T)      648          329          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.288      P=0.351N     P=0.599N     P=0.442     |P=0.335N     P=0.573N     P=0.230N     P=0.444N     | 
|POLY 3             |     P=0.341      P=0.372N     P=0.568N     P=0.489     |P=0.360N     P=0.609N     P=0.252N     P=0.471N     | 
|POLY 1.5           |     P=0.348      P=0.376N     P=0.549N     P=0.493     |P=0.366N     P=0.610N     P=0.256N     P=0.478N     | 
|POLY 6             |     P=0.334      P=0.365N     P=0.583N     P=0.487     |P=0.351N     P=0.614N     P=0.248N     P=0.463N     | 
|LOGISTIC REGRESSION|     P=0.354      P=0.365N     P=0.532N     P=0.511     |P=0.382N     P=0.599N     P=0.259N     P=0.517N     | 
|COCH-ARM / FISHERS |     P=0.361      P=0.380N     P=0.500N     P=0.500     |P=0.384N     P=0.613N     P=0.262N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.417      (e)          (e)          (e)         |P=0.399N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.53      2/47.50      1/42.28      2/45.36     |1/44.99      0/45.87      1/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     2.2%         4.2%         2.4%         4.4%        |2.2%         0.0%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    2/42 (5%)    1/35 (3%)    1/37 (3%)   |1/35 (3%)    0/37 (0%)    1/39 (3%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      725         |731 (T)      ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.405      P=0.517      P=0.732      P=0.476     |P=0.389N     P=0.489N     P=0.738N     P=0.484N     | 
|POLY 3             |     P=0.429      P=0.507      P=0.739      P=0.491     |P=0.403N     P=0.496N     P=0.756N     P=0.494N     | 
|POLY 1.5           |     P=0.434      P=0.504      P=0.745      P=0.494     |P=0.404N     P=0.498N     P=0.758N     P=0.496N     | 
|POLY 6             |     P=0.423      P=0.513      P=0.734      P=0.488     |P=0.401N     P=0.495N     P=0.755N     P=0.490N     | 
|LOGISTIC REGRESSION|     P=0.416      P=0.517      P=0.732      P=0.486     |P=0.389N     (e)          P=0.738N     (e)          | 
|COCH-ARM / FISHERS |     P=0.444      P=0.500      P=0.753N     P=0.500     |P=0.405N     P=0.500N     P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.431      (e)          (e)          (e)         |P=0.245N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     1/46.24      1/47.50      0/41.84      3/45.54     |0/44.99      0/45.87      0/45.09      0/46.46      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         0.0%         6.6%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    1/42 (2%)    0/35 (0%)    2/37 (5%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          678         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.141      P=0.751N     P=0.527N     P=0.284     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.153      P=0.755N     P=0.520N     P=0.300     |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.157      P=0.755N     P=0.514N     P=0.304     |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.150      P=0.752N     P=0.524N     P=0.296     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.151      P=0.751N     (e)          P=0.298     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.163      P=0.747N     P=0.500N     P=0.316     |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.100      (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Islets, Pancreatic                                                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/49 (0%)    3/50 (6%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.24      1/47.50      0/41.84      3/45.54     |0/44.99      0/45.87      0/45.09      1/46.51      | 
|POLY-3 PERCENT (g) |     2.2%         2.1%         0.0%         6.6%        |0.0%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |     1/40 (3%)    1/42 (2%)    0/35 (0%)    2/37 (5%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          678         |---          ---          ---          719          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.141      P=0.751N     P=0.527N     P=0.284     |P=0.215      (e)          (e)          P=0.526      | 
|POLY 3             |     P=0.153      P=0.755N     P=0.520N     P=0.300     |P=0.203      (e)          (e)          P=0.507      | 
|POLY 1.5           |     P=0.157      P=0.755N     P=0.514N     P=0.304     |P=0.202      (e)          (e)          P=0.504      | 
|POLY 6             |     P=0.150      P=0.752N     P=0.524N     P=0.296     |P=0.205      (e)          (e)          P=0.510      | 
|LOGISTIC REGRESSION|     P=0.151      P=0.751N     (e)          P=0.298     |P=0.202      (e)          (e)          P=0.507      | 
|COCH-ARM / FISHERS |     P=0.163      P=0.747N     P=0.500N     P=0.316     |P=0.199      (e)          (e)          P=0.500      | 
|ORDER RESTRICTED   |     P=0.100      (e)          (e)          (e)         |P=0.127      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     2/47.24      1/48.03      2/42.61      0/45.34     |1/45.17      2/45.87      1/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     4.2%         2.1%         4.7%         0.0%        |2.2%         4.4%         2.2%         0.0%         | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    1/35 (3%)    0/37 (0%)   |0/35 (0%)    2/37 (5%)    1/39 (3%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     482          565          639          ---         |684          731 (T)      731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.222N     P=0.494N     P=0.652      P=0.251N    |P=0.230N     P=0.513      P=0.746N     P=0.486N     | 
|POLY 3             |     P=0.215N     P=0.494N     P=0.656      P=0.246N    |P=0.241N     P=0.505      P=0.757N     P=0.494N     | 
|POLY 1.5           |     P=0.209N     P=0.497N     P=0.667      P=0.243N    |P=0.243N     P=0.503      P=0.758N     P=0.496N     | 
|POLY 6             |     P=0.221N     P=0.489N     P=0.649      P=0.250N    |P=0.238N     P=0.505      P=0.757N     P=0.492N     | 
|LOGISTIC REGRESSION|     P=0.163N     P=0.530N     P=0.638N     P=0.154N    |P=0.240N     P=0.505      P=0.761N     P=0.505N     | 
|COCH-ARM / FISHERS |     P=0.200N     P=0.500N     P=0.691N     P=0.247N    |P=0.247N     P=0.500      P=0.753N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.163N     (e)          (e)          (e)         |P=0.223N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     17/50 (34%)  25/50 (50%)  23/50 (46%)  34/50 (68%) |13/50 (26%)  15/50 (30%)  20/50 (40%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     17/46.72     25/48.11     23/44.32     34/47.29    |13/45.12     15/46.28     20/46.39     23/46.66     | 
|POLY-3 PERCENT (g) |     36.4%        52.0%        51.9%        71.9%       |28.8%        32.4%        43.1%        49.3%        | 
|TERMINAL (d)       |     16/40 (40%)  22/42 (52%)  17/35 (49%)  28/37 (76%) |11/35 (31%)  11/37 (30%)  17/39 (44%)  20/38 (53%)  | 
|FIRST INCIDENCE    |     678          582          471          551         |715          687          673          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.114      P=0.068      P<0.001 **  |P=0.034 *    P=0.474      P=0.176      P=0.060      | 
|POLY 3             |     P<0.001 **   P=0.090      P=0.097      P<0.001 **  |P=0.016 *    P=0.442      P=0.111      P=0.033 *    | 
|POLY 1.5           |     P<0.001 **   P=0.084      P=0.107      P<0.001 **  |P=0.016 *    P=0.429      P=0.106      P=0.032 *    | 
|POLY 6             |     P<0.001 **   P=0.103      P=0.096      P<0.001 **  |P=0.018 *    P=0.454      P=0.119      P=0.037 *    | 
|LOGISTIC REGRESSION|     P<0.001 **   P=0.100      P=0.076      P<0.001 **  |P=0.023 *    P=0.440      P=0.114      P=0.051      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.078      P=0.154      P<0.001 **  |P=0.015 *    P=0.412      P=0.101      P=0.030 *    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.028 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  12/50 (24%)  10/50 (20%)  9/50 (18%)  |6/50 (12%)   5/50 (10%)   6/50 (12%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     12/47.98     12/49.17     10/43.87     9/46.83     |6/45.72      5/46.39      6/46.41      11/46.76     | 
|POLY-3 PERCENT (g) |     25.0%        24.4%        22.8%        19.2%       |13.1%        10.8%        12.9%        23.5%        | 
|TERMINAL (d)       |     8/40 (20%)   8/42 (19%)   6/35 (17%)   4/37 (11%)  |2/35 (6%)    3/37 (8%)    5/39 (13%)   7/38 (18%)   | 
|FIRST INCIDENCE    |     482          493          480          551         |586          598          567          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.329N     P=0.540N     P=0.536N     P=0.376N    |P=0.096      P=0.472N     P=0.565N     P=0.205      | 
|POLY 3             |     P=0.271N     P=0.566N     P=0.498N     P=0.333N    |P=0.068      P=0.490N     P=0.610N     P=0.153      | 
|POLY 1.5           |     P=0.258N     P=0.577N     P=0.473N     P=0.327N    |P=0.067      P=0.494N     P=0.614N     P=0.150      | 
|POLY 6             |     P=0.282N     P=0.548N     P=0.516N     P=0.338N    |P=0.070      P=0.490N     P=0.609N     P=0.158      | 
|LOGISTIC REGRESSION|     P=0.207N     P=0.538      P=0.388N     P=0.266N    |P=0.068      P=0.499N     P=0.620N     P=0.154      | 
|COCH-ARM / FISHERS |     P=0.234N     P=0.592N     P=0.405N     P=0.312N    |P=0.065      P=0.500N     P=0.620N     P=0.143      | 
|ORDER RESTRICTED   |     P=0.398N     (e)          (e)          (e)         |P=0.091      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     12/50 (24%)  13/50 (26%)  10/50 (20%)  9/50 (18%)  |6/50 (12%)   5/50 (10%)   6/50 (12%)   11/50 (22%)  | 
|POLY-3 RATE (b)    |     12/47.98     13/49.17     10/43.87     9/46.83     |6/45.72      5/46.39      6/46.41      11/46.76     | 
|POLY-3 PERCENT (g) |     25.0%        26.4%        22.8%        19.2%       |13.1%        10.8%        12.9%        23.5%        | 
|TERMINAL (d)       |     8/40 (20%)   9/42 (21%)   6/35 (17%)   4/37 (11%)  |2/35 (6%)    3/37 (8%)    5/39 (13%)   7/38 (18%)   | 
|FIRST INCIDENCE    |     482          493          480          551         |586          598          567          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.304N     P=0.548      P=0.536N     P=0.376N    |P=0.096      P=0.472N     P=0.565N     P=0.205      | 
|POLY 3             |     P=0.245N     P=0.528      P=0.498N     P=0.333N    |P=0.068      P=0.490N     P=0.610N     P=0.153      | 
|POLY 1.5           |     P=0.233N     P=0.515      P=0.473N     P=0.327N    |P=0.067      P=0.494N     P=0.614N     P=0.150      | 
|POLY 6             |     P=0.256N     P=0.547      P=0.516N     P=0.338N    |P=0.070      P=0.490N     P=0.609N     P=0.158      | 
|LOGISTIC REGRESSION|     P=0.186N     P=0.443      P=0.388N     P=0.266N    |P=0.068      P=0.499N     P=0.620N     P=0.154      | 
|COCH-ARM / FISHERS |     P=0.210N     P=0.500      P=0.405N     P=0.312N    |P=0.065      P=0.500N     P=0.620N     P=0.143      | 
|ORDER RESTRICTED   |     P=0.360N     (e)          (e)          (e)         |P=0.091      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  34/50 (68%)  28/50 (56%)  37/50 (74%) |17/50 (34%)  17/50 (34%)  22/50 (44%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     27/48.17     34/49.78     28/45.47     37/47.88    |17/45.79     17/46.73     22/46.93     27/46.86     | 
|POLY-3 PERCENT (g) |     56.1%        68.3%        61.6%        77.3%       |37.1%        36.4%        46.9%        57.6%        | 
|TERMINAL (d)       |     22/40 (55%)  27/42 (64%)  20/35 (57%)  28/37 (76%) |12/35 (34%)  12/37 (32%)  18/39 (46%)  22/38 (58%)  | 
|FIRST INCIDENCE    |     482          493          471          551         |586          598          567          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.025 *    P=0.210      P=0.265      P=0.023 *   |P=0.041 *    P=0.514N     P=0.331      P=0.089      | 
|POLY 3             |     P=0.028 *    P=0.146      P=0.368      P=0.019 *   |P=0.013 *    P=0.556N     P=0.228      P=0.035 *    | 
|POLY 1.5           |     P=0.033 *    P=0.129      P=0.395      P=0.022 *   |P=0.013 *    P=0.567N     P=0.218      P=0.035 *    | 
|POLY 6             |     P=0.026 *    P=0.175      P=0.361      P=0.019 *   |P=0.014 *    P=0.548N     P=0.238      P=0.038 *    | 
|LOGISTIC REGRESSION|     P=0.039 *    P=0.103      P=0.392      P=0.023 *   |P=0.017 *    P=0.559N     P=0.223      P=0.047 *    | 
|COCH-ARM / FISHERS |     P=0.051      P=0.109      P=0.500      P=0.030 *   |P=0.014 *    P=0.583N     P=0.206      P=0.035 *    | 
|ORDER RESTRICTED   |     P=0.016 *    (e)          (e)          (e)         |P=0.028 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  35/50 (70%)  28/50 (56%)  37/50 (74%) |17/50 (34%)  17/50 (34%)  22/50 (44%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     27/48.17     35/49.78     28/45.47     37/47.88    |17/45.79     17/46.73     22/46.93     27/46.86     | 
|POLY-3 PERCENT (g) |     56.1%        70.3%        61.6%        77.3%       |37.1%        36.4%        46.9%        57.6%        | 
|TERMINAL (d)       |     22/40 (55%)  28/42 (67%)  20/35 (57%)  28/37 (76%) |12/35 (34%)  12/37 (32%)  18/39 (46%)  22/38 (58%)  | 
|FIRST INCIDENCE    |     482          493          471          551         |586          598          567          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.028 *    P=0.163      P=0.265      P=0.023 *   |P=0.041 *    P=0.514N     P=0.331      P=0.089      | 
|POLY 3             |     P=0.033 *    P=0.102      P=0.368      P=0.019 *   |P=0.013 *    P=0.556N     P=0.228      P=0.035 *    | 
|POLY 1.5           |     P=0.039 *    P=0.088      P=0.395      P=0.022 *   |P=0.013 *    P=0.567N     P=0.218      P=0.035 *    | 
|POLY 6             |     P=0.031 *    P=0.125      P=0.361      P=0.019 *   |P=0.014 *    P=0.548N     P=0.238      P=0.038 *    | 
|LOGISTIC REGRESSION|     P=0.044 *    P=0.071      P=0.392      P=0.023 *   |P=0.017 *    P=0.559N     P=0.223      P=0.047 *    | 
|COCH-ARM / FISHERS |     P=0.059      P=0.074      P=0.500      P=0.030 *   |P=0.014 *    P=0.583N     P=0.206      P=0.035 *    | 
|ORDER RESTRICTED   |     P=0.016 *    (e)          (e)          (e)         |P=0.028 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocholangiocarcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     5/47.70      2/48.21      0/42.28      0/45.34     |1/45.50      1/46.52      0/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     10.5%        4.2%         0.0%         0.0%        |2.2%         2.2%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/40 (5%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     612          582          ---          ---         |578          515          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.012N*    P=0.214N     P=0.051N     P=0.043N*   |P=0.237N     P=0.756N     P=0.504N     P=0.500N     | 
|POLY 3             |     P=0.008N**   P=0.212N     P=0.042N*    P=0.035N*   |P=0.236N     P=0.756N     P=0.498N     P=0.496N     | 
|POLY 1.5           |     P=0.008N**   P=0.215N     P=0.038N*    P=0.033N*   |P=0.236N     P=0.757N     P=0.499N     P=0.497N     | 
|POLY 6             |     P=0.009N**   P=0.209N     P=0.046N*    P=0.037N*   |P=0.235N     P=0.755N     P=0.498N     P=0.494N     | 
|LOGISTIC REGRESSION|     P=0.005N**   P=0.234N     P=0.021N*    P=0.021N*   |P=0.255N     P=0.754N     P=0.495N     P=0.548N     | 
|COCH-ARM / FISHERS |     P=0.008N**   P=0.218N     P=0.028N*    P=0.028N*   |P=0.236N     P=0.753N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.004N**   (e)          (e)          (e)         |P=0.247N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/50 (18%)   5/50 (10%)   1/50 (2%)    5/50 (10%)  |4/50 (8%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     9/46.76      5/47.75      1/42.28      5/45.74     |4/45.41      2/45.87      1/46.41      1/46.46      | 
|POLY-3 PERCENT (g) |     19.3%        10.5%        2.4%         10.9%       |8.8%         4.4%         2.2%         2.2%         | 
|TERMINAL (d)       |     8/40 (20%)   4/42 (10%)   1/35 (3%)    4/37 (11%)  |2/35 (6%)    2/37 (5%)    0/39 (0%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     666          661          729 (T)      617         |653          731 (T)      567          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.179N     P=0.171N     P=0.017N*    P=0.240N    |P=0.102N     P=0.321N     P=0.172N     P=0.162N     | 
|POLY 3             |     P=0.146N     P=0.181N     P=0.013N*    P=0.205N    |P=0.108N     P=0.333N     P=0.172N     P=0.172N     | 
|POLY 1.5           |     P=0.140N     P=0.187N     P=0.011N*    P=0.201N    |P=0.109N     P=0.334N     P=0.175N     P=0.174N     | 
|POLY 6             |     P=0.152N     P=0.172N     P=0.014N*    P=0.208N    |P=0.106N     P=0.334N     P=0.170N     P=0.169N     | 
|LOGISTIC REGRESSION|     P=0.151N     P=0.179N     P=0.015N*    P=0.208N    |P=0.112N     P=0.331N     P=0.181N     P=0.175N     | 
|COCH-ARM / FISHERS |     P=0.132N     P=0.194N     P=0.008N**   P=0.194N    |P=0.111N     P=0.339N     P=0.181N     P=0.181N     | 
|ORDER RESTRICTED   |     P=0.035N*    (e)          (e)          (e)         |P=0.090N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     5/50 (10%)   1/50 (2%)    3/50 (6%)    5/50 (10%)  |0/50 (0%)    2/50 (4%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     5/46.53      1/47.50      3/42.54      5/45.77     |0/44.99      2/46.13      1/45.87      1/46.63      | 
|POLY-3 PERCENT (g) |     10.8%        2.1%         7.1%         10.9%       |0.0%         4.3%         2.2%         2.1%         | 
|TERMINAL (d)       |     5/40 (13%)   1/42 (2%)    2/35 (6%)    4/37 (11%)  |0/35 (0%)    1/37 (3%)    1/39 (3%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      659          607         |---          662          731 (T)      687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.331      P=0.092N     P=0.431N     P=0.581     |P=0.521      P=0.248      P=0.522      P=0.519      | 
|POLY 3             |     P=0.369      P=0.097N     P=0.407N     P=0.620     |P=0.517      P=0.243      P=0.504      P=0.507      | 
|POLY 1.5           |     P=0.376      P=0.099N     P=0.393N     P=0.623     |P=0.511      P=0.240      P=0.502      P=0.505      | 
|POLY 6             |     P=0.362      P=0.093N     P=0.415N     P=0.618     |P=0.526      P=0.245      P=0.505      P=0.511      | 
|LOGISTIC REGRESSION|     P=0.365      P=0.092N     P=0.419N     P=0.613     |P=0.501      P=0.237      P=0.522      P=0.496      | 
|COCH-ARM / FISHERS |     P=0.389      P=0.102N     P=0.357N     P=0.630N    |P=0.500      P=0.247      P=0.500      P=0.500      | 
|ORDER RESTRICTED   |     P=0.324      (e)          (e)          (e)         |P=0.275      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     14/50 (28%)  5/50 (10%)   3/50 (6%)    10/50 (20%) |4/50 (8%)    4/50 (8%)    2/50 (4%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     14/46.76     5/47.75      3/42.54      10/46.16    |4/45.41      4/46.13      2/46.41      2/46.63      | 
|POLY-3 PERCENT (g) |     29.9%        10.5%        7.1%         21.7%       |8.8%         8.7%         4.3%         4.3%         | 
|TERMINAL (d)       |     13/40 (33%)  4/42 (10%)   2/35 (6%)    8/37 (22%)  |2/35 (6%)    3/37 (8%)    1/39 (3%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     666          661          659          607         |653          662          567          687          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.394N     P=0.016N*    P=0.009N**   P=0.313N    |P=0.191N     P=0.618N     P=0.316N     P=0.307N     | 
|POLY 3             |     P=0.326N     P=0.016N*    P=0.005N**   P=0.250N    |P=0.203N     P=0.635N     P=0.327N     P=0.325N     | 
|POLY 1.5           |     P=0.316N     P=0.017N*    P=0.004N**   P=0.248N    |P=0.205N     P=0.638N     P=0.331N     P=0.329N     | 
|POLY 6             |     P=0.335N     P=0.014N*    P=0.006N**   P=0.249N    |P=0.198N     P=0.634N     P=0.325N     P=0.319N     | 
|LOGISTIC REGRESSION|     P=0.337N     P=0.016N*    P=0.007N**   P=0.265N    |P=0.211N     P=0.640N     P=0.339N     P=0.333N     | 
|COCH-ARM / FISHERS |     P=0.301N     P=0.020N*    P=0.003N**   P=0.241N    |P=0.210N     P=0.643N     P=0.339N     P=0.339N     | 
|ORDER RESTRICTED   |     P=0.019N*    (e)          (e)          (e)         |P=0.302N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |0/49 (0%)    2/50 (4%)    1/48 (2%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |                                                        |0/44.98      2/45.98      1/44.09      3/46.46      | 
|POLY-3 PERCENT (g) |                                                        |0.0%         4.4%         2.3%         6.5%         | 
|TERMINAL (d)       |                                                        |0/35 (0%)    1/37 (3%)    1/38 (3%)    3/38 (8%)    | 
|FIRST INCIDENCE    |                                                        |---          702          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.119      P=0.251      P=0.516      P=0.136      | 
|POLY 3             |                                                        |P=0.109      P=0.242      P=0.496      P=0.125      | 
|POLY 1.5           |                                                        |P=0.107      P=0.241      P=0.495      P=0.123      | 
|POLY 6             |                                                        |P=0.112      P=0.243      P=0.498      P=0.127      | 
|LOGISTIC REGRESSION|                                                        |P=0.115      P=0.241      P=0.516      P=0.136      | 
|COCH-ARM / FISHERS |                                                        |P=0.106      P=0.253      P=0.495      P=0.125      | 
|ORDER RESTRICTED   |                                                        |P=0.061      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/47 (0%)    0/48 (0%)    1/49 (2%)   |7/50 (14%)   9/49 (18%)   4/48 (8%)    6/49 (12%)   | 
|POLY-3 RATE (b)    |     0/46.53      0/45.01      0/40.84      1/44.34     |7/44.99      9/45.05      4/44.41      6/45.49      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.3%        |15.6%        20.0%        9.0%         13.2%        | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/34 (0%)    1/36 (3%)   |7/35 (20%)   8/36 (22%)   3/39 (8%)    6/38 (16%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |731 (T)      683          696          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.183      (e)          (e)          P=0.479     |P=0.249N     P=0.415      P=0.207N     P=0.435N     | 
|POLY 3             |     P=0.195      (e)          (e)          P=0.490     |P=0.302N     P=0.393      P=0.268N     P=0.491N     | 
|POLY 1.5           |     P=0.197      (e)          (e)          P=0.493     |P=0.309N     P=0.386      P=0.276N     P=0.499N     | 
|POLY 6             |     P=0.192      (e)          (e)          P=0.488     |P=0.290N     P=0.398      P=0.258N     P=0.478N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.479     |P=0.267N     P=0.392      P=0.246N     P=0.435N     | 
|COCH-ARM / FISHERS |     P=0.200      (e)          (e)          P=0.495     |P=0.323N     P=0.376      P=0.286N     P=0.516N     | 
|ORDER RESTRICTED   |     P=0.112      (e)          (e)          (e)         |P=0.292N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Intermedia                                                                                                 | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/47 (0%)    0/48 (0%)    0/49 (0%)   |0/50 (0%)    0/49 (0%)    2/48 (4%)    0/49 (0%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/45.01      0/40.84      0/44.34     |0/44.99      0/44.87      2/44.28      0/45.49      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.5%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/34 (0%)    0/36 (0%)   |0/35 (0%)    0/36 (0%)    2/39 (5%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.613      (e)          P=0.262      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.605      (e)          P=0.234      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.601      (e)          P=0.231      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.614      (e)          P=0.236      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          P=0.262      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.591      (e)          P=0.237      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.244      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |4/50 (8%)    2/50 (4%)    1/50 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     1/46.73      0/47.50      0/42.28      2/46.39     |4/45.61      2/45.87      1/46.45      5/46.61      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         4.3%        |8.8%         4.4%         2.2%         10.7%        | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |2/35 (6%)    2/37 (5%)    0/39 (0%)    3/38 (8%)    | 
|FIRST INCIDENCE    |     676          ---          ---          513         |586          731 (T)      551          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.238      P=0.491N     P=0.525N     P=0.489     |P=0.382      P=0.318N     P=0.171N     P=0.552      | 
|POLY 3             |     P=0.240      P=0.497N     P=0.520N     P=0.497     |P=0.351      P=0.335N     P=0.173N     P=0.514      | 
|POLY 1.5           |     P=0.242      P=0.498N     P=0.514N     P=0.498     |P=0.349      P=0.336N     P=0.176N     P=0.510      | 
|POLY 6             |     P=0.237      P=0.494N     P=0.525N     P=0.497     |P=0.356      P=0.337N     P=0.172N     P=0.520      | 
|LOGISTIC REGRESSION|     P=0.261      P=0.511N     P=0.489N     P=0.627     |P=0.342      P=0.336N     P=0.181N     P=0.506      | 
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.500N     P=0.500     |P=0.344      P=0.339N     P=0.181N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.131      (e)          (e)          (e)         |P=0.212      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |4/50 (8%)    2/50 (4%)    1/50 (2%)    5/50 (10%)   | 
|POLY-3 RATE (b)    |     1/46.73      0/47.50      0/42.28      2/46.39     |4/45.61      2/45.87      1/46.45      5/46.61      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         4.3%        |8.8%         4.4%         2.2%         10.7%        | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |2/35 (6%)    2/37 (5%)    0/39 (0%)    3/38 (8%)    | 
|FIRST INCIDENCE    |     676          ---          ---          513         |586          731 (T)      551          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.238      P=0.491N     P=0.525N     P=0.489     |P=0.382      P=0.318N     P=0.171N     P=0.552      | 
|POLY 3             |     P=0.240      P=0.497N     P=0.520N     P=0.497     |P=0.351      P=0.335N     P=0.173N     P=0.514      | 
|POLY 1.5           |     P=0.242      P=0.498N     P=0.514N     P=0.498     |P=0.349      P=0.336N     P=0.176N     P=0.510      | 
|POLY 6             |     P=0.237      P=0.494N     P=0.525N     P=0.497     |P=0.356      P=0.337N     P=0.172N     P=0.520      | 
|LOGISTIC REGRESSION|     P=0.261      P=0.511N     P=0.489N     P=0.627     |P=0.342      P=0.336N     P=0.181N     P=0.506      | 
|COCH-ARM / FISHERS |     P=0.246      P=0.500N     P=0.500N     P=0.500     |P=0.344      P=0.339N     P=0.181N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.131      (e)          (e)          (e)         |P=0.212      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrous Histiocytoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.73      0/47.50      0/42.28      1/45.99     |2/45.48      1/45.87      0/45.87      1/46.46      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         2.2%        |4.4%         2.2%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |1/35 (3%)    1/37 (3%)    0/39 (0%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     676          ---          ---          513         |586          731 (T)      ---          731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.585      P=0.491N     P=0.525N     P=0.755     |P=0.350N     P=0.482N     P=0.228N     P=0.478N     | 
|POLY 3             |     P=0.588      P=0.497N     P=0.520N     P=0.757     |P=0.366N     P=0.497N     P=0.235N     P=0.493N     | 
|POLY 1.5           |     P=0.590      P=0.498N     P=0.514N     P=0.758     |P=0.366N     P=0.498N     P=0.236N     P=0.495N     | 
|POLY 6             |     P=0.584      P=0.494N     P=0.525N     P=0.756     |P=0.364N     P=0.498N     P=0.235N     P=0.489N     | 
|LOGISTIC REGRESSION|     P=0.634      P=0.511N     P=0.489N     P=0.688N    |P=0.368N     P=0.501N     P=0.238N     P=0.510N     | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.366N     P=0.500N     P=0.247N     P=0.500N     | 
|ORDER RESTRICTED   |     P=0.399      (e)          (e)          (e)         |P=0.218N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/47.50      0/42.28      0/45.34     |2/45.12      1/45.87      0/45.87      4/46.61      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         2.2%         0.0%         8.6%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |1/35 (3%)    1/37 (3%)    0/39 (0%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |697          731 (T)      ---          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.192      P=0.484N     P=0.228N     P=0.386      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.167      P=0.494N     P=0.233N     P=0.352      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.166      P=0.497N     P=0.235N     P=0.348      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.169      P=0.494N     P=0.232N     P=0.360      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.173      P=0.493N     P=0.234N     P=0.352      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.165      P=0.500N     P=0.247N     P=0.339      | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.082      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Spleen                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/49 (0%)    0/49 (0%)   |1/50 (2%)    2/50 (4%)    2/49 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.53      0/47.50      0/41.84      0/44.91     |1/44.99      2/45.98      2/45.09      1/46.56      | 
|POLY-3 PERCENT (g) |     2.2%         0.0%         0.0%         0.0%        |2.2%         4.4%         4.4%         2.2%         | 
|TERMINAL (d)       |     1/40 (3%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |1/35 (3%)    1/37 (3%)    2/39 (5%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      ---          ---          ---         |731 (T)      702          731 (T)      705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.320N     P=0.490N     P=0.527N     P=0.516N    |P=0.523N     P=0.519      P=0.538      P=0.738N     | 
|POLY 3             |     P=0.315N     P=0.496N     P=0.521N     P=0.507N    |P=0.543N     P=0.508      P=0.501      P=0.753N     | 
|POLY 1.5           |     P=0.313N     P=0.498N     P=0.517N     P=0.506N    |P=0.547N     P=0.504      P=0.497      P=0.755N     | 
|POLY 6             |     P=0.317N     P=0.493N     P=0.524N     P=0.508N    |P=0.535N     P=0.510      P=0.504      P=0.749N     | 
|LOGISTIC REGRESSION|     P=0.320N     (e)          (e)          (e)         |P=0.542N     P=0.508      P=0.538      P=0.756N     | 
|COCH-ARM / FISHERS |     P=0.308N     P=0.500N     P=0.505N     P=0.505N    |P=0.556N     P=0.500      P=0.492      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.127N     (e)          (e)          (e)         |P=0.536N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/47.50      0/42.28      2/45.34     |1/44.99      0/45.87      3/45.87      1/46.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.4%        |2.2%         0.0%         6.5%         2.2%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    2/37 (5%)   |1/35 (3%)    0/37 (0%)    3/39 (8%)    1/38 (3%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |731 (T)      ---          731 (T)      731 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.041 *    (e)          (e)          P=0.221     |P=0.495      P=0.489N     P=0.344      P=0.743N     | 
|POLY 3             |     P=0.043 *    (e)          (e)          P=0.231     |P=0.483      P=0.496N     P=0.312      P=0.753N     | 
|POLY 1.5           |     P=0.044 *    (e)          (e)          P=0.234     |P=0.479      P=0.498N     P=0.310      P=0.756N     | 
|POLY 6             |     P=0.042 *    (e)          (e)          P=0.229     |P=0.491      P=0.495N     P=0.315      P=0.750N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.221     |P=0.495      (e)          P=0.344      P=0.743N     | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.469      P=0.500N     P=0.309      P=0.753N     | 
|ORDER RESTRICTED   |     P=0.027 *    (e)          (e)          (e)         |P=0.273      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/46.53      0/47.50      0/42.28      1/45.34     |1/44.99      0/45.87      3/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         2.2%        |2.2%         0.0%         6.5%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    1/37 (3%)   |1/35 (3%)    0/37 (0%)    3/39 (8%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          729 (T)     |731 (T)      ---          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.187      (e)          (e)          P=0.484     |P=0.477N     P=0.489N     P=0.344      P=0.484N     | 
|POLY 3             |     P=0.194      (e)          (e)          P=0.495     |P=0.490N     P=0.496N     P=0.312      P=0.494N     | 
|POLY 1.5           |     P=0.196      (e)          (e)          P=0.497     |P=0.493N     P=0.498N     P=0.310      P=0.496N     | 
|POLY 6             |     P=0.192      (e)          (e)          P=0.493     |P=0.483N     P=0.495N     P=0.315      P=0.490N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.484     |P=0.477N     (e)          P=0.344      (e)          | 
|COCH-ARM / FISHERS |     P=0.198      (e)          (e)          P=0.500     |P=0.500N     P=0.500N     P=0.309      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.115      (e)          (e)          (e)         |P=0.267N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     0/46.53      2/47.50      0/42.28      0/45.34     |                                                    | 
|POLY-3 PERCENT (g) |     0.0%         4.2%         0.0%         0.0%        |                                                    | 
|TERMINAL (d)       |     0/40 (0%)    2/42 (5%)    0/35 (0%)    0/37 (0%)   |                                                    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.428N     P=0.249      (e)          (e)         |                                                    | 
|POLY 3             |     P=0.413N     P=0.242      (e)          (e)         |                                                    | 
|POLY 1.5           |     P=0.411N     P=0.240      (e)          (e)         |                                                    | 
|POLY 6             |     P=0.415N     P=0.245      (e)          (e)         |                                                    | 
|LOGISTIC REGRESSION|     (e)          P=0.249      (e)          (e)         |                                                    | 
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |                                                    | 
|ORDER RESTRICTED   |     P=0.256N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    2/49 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     0/46.53      2/46.69      0/42.28      0/45.34     |1/44.99      0/45.87      0/44.87      0/44.56      | 
|POLY-3 PERCENT (g) |     0.0%         4.3%         0.0%         0.0%        |2.2%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/40 (0%)    2/42 (5%)    0/35 (0%)    0/37 (0%)   |1/35 (3%)    0/37 (0%)    0/38 (0%)    0/37 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |731 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.428N     P=0.249      (e)          (e)         |P=0.299N     P=0.489N     P=0.484N     P=0.489N     | 
|POLY 3             |     P=0.412N     P=0.238      (e)          (e)         |P=0.315N     P=0.496N     P=0.501N     P=0.502N     | 
|POLY 1.5           |     P=0.409N     P=0.236      (e)          (e)         |P=0.314N     P=0.498N     P=0.502N     P=0.504N     | 
|POLY 6             |     P=0.413N     P=0.242      (e)          (e)         |P=0.317N     P=0.495N     P=0.499N     P=0.498N     | 
|LOGISTIC REGRESSION|     (e)          P=0.249      (e)          (e)         |P=0.299N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.404N     P=0.242      (e)          (e)         |P=0.311N     P=0.500N     P=0.505N     P=0.510N     | 
|ORDER RESTRICTED   |     P=0.253N     (e)          (e)          (e)         |P=0.122N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.99      0/45.87      2/46.17      0/46.46      | 
|POLY-3 PERCENT (g) |                                                        |2.2%         0.0%         4.3%         0.0%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    0/37 (0%)    0/39 (0%)    0/38 (0%)    | 
|FIRST INCIDENCE    |                                                        |731 (T)      ---          684          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.439N     P=0.489N     P=0.518      P=0.484N     | 
|POLY 3             |                                                        |P=0.454N     P=0.496N     P=0.509      P=0.494N     | 
|POLY 1.5           |                                                        |P=0.456N     P=0.498N     P=0.505      P=0.496N     | 
|POLY 6             |                                                        |P=0.449N     P=0.495N     P=0.514      P=0.490N     | 
|LOGISTIC REGRESSION|                                                        |P=0.459N     (e)          P=0.502      (e)          | 
|COCH-ARM / FISHERS |                                                        |P=0.461N     P=0.500N     P=0.500      P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.319N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    3/50 (6%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |3/45.48      3/46.23      2/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |                                                        |6.6%         6.5%         4.4%         0.0%         | 
|TERMINAL (d)       |                                                        |2/35 (6%)    2/37 (5%)    2/39 (5%)    0/38 (0%)    | 
|FIRST INCIDENCE    |                                                        |586          628          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.064N     P=0.639N     P=0.461N     P=0.112N     | 
|POLY 3             |                                                        |P=0.069N     P=0.655N     P=0.496N     P=0.115N     | 
|POLY 1.5           |                                                        |P=0.070N     P=0.658N     P=0.497N     P=0.116N     | 
|POLY 6             |                                                        |P=0.067N     P=0.653N     P=0.496N     P=0.113N     | 
|LOGISTIC REGRESSION|                                                        |P=0.071N     P=0.662      P=0.499N     P=0.124N     | 
|COCH-ARM / FISHERS |                                                        |P=0.072N     P=0.661N     P=0.500N     P=0.121N     | 
|ORDER RESTRICTED   |                                                        |P=0.092N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |4/50 (8%)    3/50 (6%)    2/50 (4%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |                                                        |4/45.48      3/46.23      2/45.87      0/46.46      | 
|POLY-3 PERCENT (g) |                                                        |8.8%         6.5%         4.4%         0.0%         | 
|TERMINAL (d)       |                                                        |3/35 (9%)    2/37 (5%)    2/39 (5%)    0/38 (0%)    | 
|FIRST INCIDENCE    |                                                        |586          628          731 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.032N*    P=0.474N     P=0.298N     P=0.057N     | 
|POLY 3             |                                                        |P=0.035N*    P=0.491N     P=0.333N     P=0.058N     | 
|POLY 1.5           |                                                        |P=0.036N*    P=0.495N     P=0.335N     P=0.058N     | 
|POLY 6             |                                                        |P=0.034N*    P=0.489N     P=0.332N     P=0.056N     | 
|LOGISTIC REGRESSION|                                                        |P=0.036N*    P=0.500N     P=0.334N     P=0.063N     | 
|COCH-ARM / FISHERS |                                                        |P=0.037N*    P=0.500N     P=0.339N     P=0.059N     | 
|ORDER RESTRICTED   |                                                        |P=0.035N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangioma                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     1/46.90      0/47.50      0/42.28      0/45.34     |0/44.99      0/45.87      2/45.87      1/46.86      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         0.0%         0.0%        |0.0%         0.0%         4.4%         2.1%         | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |0/35 (0%)    0/37 (0%)    2/39 (5%)    0/38 (0%)    | 
|FIRST INCIDENCE    |     622          ---          ---          ---         |---          ---          731 (T)      617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.316N     P=0.491N     P=0.523N     P=0.509N    |P=0.259      (e)          P=0.262      P=0.509      | 
|POLY 3             |     P=0.310N     P=0.497N     P=0.521N     P=0.507N    |P=0.259      (e)          P=0.242      P=0.508      | 
|POLY 1.5           |     P=0.309N     P=0.499N     P=0.515N     P=0.504N    |P=0.255      (e)          P=0.240      P=0.505      | 
|POLY 6             |     P=0.312N     P=0.496N     P=0.526N     P=0.510N    |P=0.268      (e)          P=0.243      P=0.513      | 
|LOGISTIC REGRESSION|     P=0.280N     P=0.518N     P=0.447N     P=0.443N    |P=0.243      (e)          P=0.262      P=0.470      | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.246      (e)          P=0.247      P=0.500      | 
|ORDER RESTRICTED   |     P=0.127N     (e)          (e)          (e)         |P=0.171      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |3/50 (6%)    4/50 (8%)    7/50 (14%)   1/50 (2%)    | 
|POLY-3 RATE (b)    |     3/47.24      1/48.03      3/42.72      1/45.34     |3/45.17      4/45.98      7/46.17      1/46.56      | 
|POLY-3 PERCENT (g) |     6.4%         2.1%         7.0%         2.2%        |6.6%         8.7%         15.2%        2.2%         | 
|TERMINAL (d)       |     2/40 (5%)    0/42 (0%)    1/35 (3%)    1/37 (3%)   |2/35 (6%)    3/37 (8%)    5/39 (13%)   0/38 (0%)    | 
|FIRST INCIDENCE    |     482          565          639          729 (T)     |684          702          684          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.348N     P=0.299N     P=0.607      P=0.330N    |P=0.242N     P=0.525      P=0.199      P=0.277N     | 
|POLY 3             |     P=0.336N     P=0.300N     P=0.615      P=0.320N    |P=0.257N     P=0.510      P=0.166      P=0.295N     | 
|POLY 1.5           |     P=0.327N     P=0.303N     P=0.628      P=0.315N    |P=0.263N     P=0.506      P=0.163      P=0.298N     | 
|POLY 6             |     P=0.345N     P=0.294N     P=0.607      P=0.325N    |P=0.247N     P=0.511      P=0.170      P=0.289N     | 
|LOGISTIC REGRESSION|     P=0.284N     P=0.321N     P=0.628N     P=0.262N    |P=0.263N     P=0.511      P=0.166      P=0.298N     | 
|COCH-ARM / FISHERS |     P=0.313N     P=0.309N     P=0.661N     P=0.309N    |P=0.278N     P=0.500      P=0.159      P=0.309N     | 
|ORDER RESTRICTED   |     P=0.260N     (e)          (e)          (e)         |P=0.121N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |3/50 (6%)    4/50 (8%)    9/50 (18%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     4/47.62      1/48.03      3/42.72      1/45.34     |3/45.17      4/45.98      9/46.17      2/46.96      | 
|POLY-3 PERCENT (g) |     8.4%         2.1%         7.0%         2.2%        |6.6%         8.7%         19.5%        4.3%         | 
|TERMINAL (d)       |     2/40 (5%)    0/42 (0%)    1/35 (3%)    1/37 (3%)   |2/35 (6%)    3/37 (8%)    7/39 (18%)   0/38 (0%)    | 
|FIRST INCIDENCE    |     482          565          639          729 (T)     |684          702          684          617          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.226N     P=0.177N     P=0.560N     P=0.202N    |P=0.417N     P=0.525      P=0.088      P=0.464N     | 
|POLY 3             |     P=0.213N     P=0.176N     P=0.559N     P=0.194N    |P=0.433N     P=0.510      P=0.064      P=0.482N     | 
|POLY 1.5           |     P=0.206N     P=0.178N     P=0.542N     P=0.188N    |P=0.444N     P=0.506      P=0.062      P=0.488N     | 
|POLY 6             |     P=0.221N     P=0.173N     P=0.571N     P=0.200N    |P=0.414N     P=0.511      P=0.066      P=0.473N     | 
|LOGISTIC REGRESSION|     P=0.165N     P=0.179N     P=0.438N     P=0.133N    |P=0.453N     P=0.511      P=0.066      P=0.505N     | 
|COCH-ARM / FISHERS |     P=0.194N     P=0.181N     P=0.500N     P=0.181N    |P=0.467N     P=0.500      P=0.061      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.127N     (e)          (e)          (e)         |P=0.176N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    1/50 (2%)   |3/50 (6%)    0/50 (0%)    1/50 (2%)    6/50 (12%)   | 
|POLY-3 RATE (b)    |     1/46.97      0/47.50      1/42.92      1/45.77     |3/45.24      0/45.87      1/46.02      6/47.30      | 
|POLY-3 PERCENT (g) |     2.1%         0.0%         2.3%         2.2%        |6.6%         0.0%         2.2%         12.7%        | 
|TERMINAL (d)       |     0/40 (0%)    0/42 (0%)    0/35 (0%)    0/37 (0%)   |1/35 (3%)    0/37 (0%)    0/39 (0%)    2/38 (5%)    | 
|FIRST INCIDENCE    |     598          ---          520          607         |691          ---          695          535          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.523      P=0.508N     P=0.728      P=0.746     |P=0.065      P=0.119N     P=0.293N     P=0.290      | 
|POLY 3             |     P=0.529      P=0.498N     P=0.740      P=0.755     |P=0.050      P=0.116N     P=0.299N     P=0.265      | 
|POLY 1.5           |     P=0.533      P=0.499N     P=0.746      P=0.757     |P=0.049 *    P=0.117N     P=0.302N     P=0.257      | 
|POLY 6             |     P=0.524      P=0.496N     P=0.736      P=0.753     |P=0.052      P=0.116N     P=0.297N     P=0.275      | 
|LOGISTIC REGRESSION|     P=0.591      P=0.520N     P=0.667N     P=0.694N    |P=0.049 *    P=0.119N     P=0.303N     P=0.238      | 
|COCH-ARM / FISHERS |     P=0.539      P=0.500N     P=0.753N     P=0.753N    |P=0.050      P=0.121N     P=0.309N     P=0.243      | 
|ORDER RESTRICTED   |     P=0.511      (e)          (e)          (e)         |P=0.024 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    1/50 (2%)    2/50 (4%)   |13/50 (26%)  5/50 (10%)   11/50 (22%)  13/50 (26%)  | 
|POLY-3 RATE (b)    |     1/46.53      3/47.50      1/42.28      2/45.42     |13/45.34     5/46.26      11/47.67     13/48.27     | 
|POLY-3 PERCENT (g) |     2.2%         6.3%         2.4%         4.4%        |28.7%        10.8%        23.1%        26.9%        | 
|TERMINAL (d)       |     1/40 (3%)    3/42 (7%)    1/35 (3%)    1/37 (3%)   |11/35 (31%)  4/37 (11%)   8/39 (21%)   9/38 (24%)   | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      729 (T)      710         |653          620          75           329          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.485      P=0.323      P=0.732      P=0.482     |P=0.371      P=0.027N*    P=0.319N     P=0.498N     | 
|POLY 3             |     P=0.509      P=0.313      P=0.739      P=0.492     |P=0.349      P=0.027N*    P=0.352N     P=0.517N     | 
|POLY 1.5           |     P=0.515      P=0.310      P=0.745      P=0.495     |P=0.335      P=0.029N*    P=0.367N     P=0.538N     | 
|POLY 6             |     P=0.504      P=0.318      P=0.734      P=0.489     |P=0.366      P=0.026N*    P=0.340N     P=0.495N     | 
|LOGISTIC REGRESSION|     P=0.497      P=0.323      P=0.732      P=0.487     |P=0.284      P=0.030N*    P=0.411N     P=0.588      | 
|COCH-ARM / FISHERS |     P=0.526      P=0.309      P=0.753N     P=0.500     |P=0.299      P=0.033N*    P=0.408N     P=0.590N     | 
|ORDER RESTRICTED   |     P=0.449      (e)          (e)          (e)         |P=0.265N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     27/50 (54%)  32/50 (64%)  29/50 (58%)  37/50 (74%) |29/50 (58%)  29/50 (58%)  30/50 (60%)  33/50 (66%)  | 
|POLY-3 RATE (b)    |     27/47.79     32/48.36     29/45.16     37/47.75    |29/46.02     29/46.92     30/47.20     33/47.96     | 
|POLY-3 PERCENT (g) |     56.5%        66.2%        64.2%        77.5%       |63.0%        61.8%        63.6%        68.8%        | 
|TERMINAL (d)       |     23/40 (58%)  28/42 (67%)  21/35 (60%)  30/37 (81%) |24/35 (69%)  22/37 (60%)  24/39 (62%)  28/38 (74%)  | 
|FIRST INCIDENCE    |     598          582          471          551         |586          628          567          329          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.012 *    P=0.310      P=0.203      P=0.016 *   |P=0.387      P=0.467N     P=0.448N     P=0.460      | 
|POLY 3             |     P=0.021 *    P=0.220      P=0.289      P=0.021 *   |P=0.276      P=0.538N     P=0.564      P=0.352      | 
|POLY 1.5           |     P=0.025 *    P=0.214      P=0.317      P=0.023 *   |P=0.260      P=0.557N     P=0.537      P=0.329      | 
|POLY 6             |     P=0.020 *    P=0.232      P=0.277      P=0.020 *   |P=0.297      P=0.523N     P=0.581N     P=0.379      | 
|LOGISTIC REGRESSION|     P=0.019 *    P=0.239      P=0.270      P=0.020 *   |P=0.249      P=0.530N     P=0.551      P=0.316      | 
|COCH-ARM / FISHERS |     P=0.036 *    P=0.208      P=0.420      P=0.030 *   |P=0.210      P=0.580N     P=0.500      P=0.268      | 
|ORDER RESTRICTED   |     P=0.016 *    (e)          (e)          (e)         |P=0.405      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  04/29/04                           EXPERIMENT: 97006 TEST: 02                                            Page 21      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -                  METHYL ISOBUTYL KETONE         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     29/50 (58%)  21/50 (42%)  16/50 (32%)  20/50 (40%) |30/50 (60%)  22/50 (44%)  28/50 (56%)  31/50 (62%)  | 
|POLY-3 RATE (b)    |     29/49.80     21/49.88     16/45.59     20/48.30    |30/47.18     22/47.80     28/49.34     31/49.28     | 
|POLY-3 PERCENT (g) |     58.2%        42.1%        35.1%        41.4%       |63.6%        46.0%        56.8%        62.9%        | 
|TERMINAL (d)       |     20/40 (50%)  15/42 (36%)  9/35 (26%)   12/37 (32%) |19/35 (54%)  16/37 (43%)  20/39 (51%)  21/38 (55%)  | 
|FIRST INCIDENCE    |     482          493          412          513         |578          515          75           329          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.159N     P=0.088N     P=0.059N     P=0.143N    |P=0.423      P=0.084N     P=0.296N     P=0.475N     | 
|POLY 3             |     P=0.075N     P=0.078N     P=0.018N*    P=0.070N    |P=0.340      P=0.062N     P=0.317N     P=0.557N     | 
|POLY 1.5           |     P=0.067N     P=0.079N     P=0.013N*    P=0.063N    |P=0.324      P=0.067N     P=0.338N     P=0.578N     | 
|POLY 6             |     P=0.086N     P=0.077N     P=0.024N*    P=0.078N    |P=0.352      P=0.065N     P=0.310N     P=0.548N     | 
|LOGISTIC REGRESSION|     P=0.041N*    P=0.121N     P=0.005N**   P=0.035N*   |P=0.255      P=0.074N     P=0.420N     P=0.514      | 
|COCH-ARM / FISHERS |     P=0.056N     P=0.081N     P=0.008N**   P=0.055N    |P=0.258      P=0.080N     P=0.420N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.030N*    (e)          (e)          (e)         |P=0.324N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      450 PPM      900 PPM      1800 PPM    |CONTROL      450 PPM      900 PPM      1800 PPM     | 
|                   |                                                        |                                                    | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     45/50 (90%)  41/50 (82%)  36/50 (72%)  45/50 (90%) |42/50 (84%)  40/50 (80%)  40/50 (80%)  42/50 (84%)  | 
|POLY-3 RATE (b)    |     45/50.00     41/50.00     36/47.05     45/48.95    |42/47.18     40/48.67     40/49.70     42/49.68     | 
|POLY-3 PERCENT (g) |     90.0%        82.0%        76.5%        91.9%       |89.0%        82.2%        80.5%        84.5%        | 
|TERMINAL (d)       |     35/40 (88%)  33/42 (79%)  25/35 (71%)  34/37 (92%) |31/35 (89%)  29/37 (78%)  30/39 (77%)  31/38 (82%)  | 
|FIRST INCIDENCE    |     482          493          412          513         |578          515          75           329          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.222      P=0.181N     P=0.313N     P=0.345     |P=0.354N     P=0.301N     P=0.213N     P=0.339N     | 
|POLY 3             |     P=0.372      P=0.194N     P=0.061N     P=0.506     |P=0.387N     P=0.251N     P=0.184N     P=0.361N     | 
|POLY 1.5           |     P=0.419      P=0.194N     P=0.045N*    P=0.553     |P=0.431N     P=0.305N     P=0.232N     P=0.424N     | 
|POLY 6             |     P=0.327      P=0.194N     P=0.082N     P=0.458     |P=0.357N     P=0.215N     P=0.154N     P=0.318N     | 
|LOGISTIC REGRESSION|     P=0.470      (e)          P=0.035N*    P=0.611     |P=0.534      P=0.331N     P=0.381N     P=0.549N     | 
|COCH-ARM / FISHERS |     P=0.513      P=0.194N     P=0.020N*    P=0.630N    |P=0.500      P=0.398N     P=0.398N     P=0.607N     | 
|ORDER RESTRICTED   |     P=0.152      (e)          (e)          (e)         |P=0.295N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
                                                                                                                                   
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).                                                    
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.