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TDMS Study 99033-01 Pathology Tables

NTP  EXP/TEST: 99033-01                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                             PAGE: 1
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/05/03
ROUTE: DOSED FEED                                                                                                 TIME: 13:36:54

                                                         EIS REPORT 03
                                                      FINAL #3 TG.AC MICE


       FACILITY:  BIORELIANCE

       NTP C#:  C99033

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  22839-47-0

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE 001    VEHICLE CONTROL
                               INCLUDE 002    3125 PPM
                               INCLUDE 003    6250 PPM
                               INCLUDE 004    12500   PPM
                               INCLUDE 005    25000   PPM
                               INCLUDE 006    50000   PPM
                               INCLUDE 008    VEHICLE CONTROL
                               INCLUDE 009    3125 PPM
                               INCLUDE 010    6250 PPM
                               INCLUDE 011    12500   PPM
                               INCLUDE 012    25000   PPM
                               INCLUDE 013    50000   PPM

NTP  EXP/TEST: 99033-01                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                             PAGE: 2
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/05/03
ROUTE: DOSED FEED                                           EISRPT03                                              TIME: 13:36:54
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 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: FEMALE      WEEK ON DOSE: 40     FIRST DOSE: 10/11/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 VEHICLE CONTROL    15     16.6    1.1        11     26.7    2.1                     11      9.9    1.4

 3125 PPM           15     16.6    0.6        10     25.4    1.4        95.1         10      8.7    1.2

 6250 PPM           15     15.8    1.3         9     26.9    2.4       100.7          9     10.7    2.2

 12500   PPM        15     15.5    2.1         9     26.5    2.5        99.2          9     10.5    2.8

 25000   PPM        15     16.4    1.4        11     26.5    3.3        99.2         11      9.5    3.3

 50000   PPM        15     16.6    1.0         8     28.3    2.6       105.9          8     11.7    2.5




----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: MALE        WEEK ON DOSE: 40     FIRST DOSE: 10/11/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 VEHICLE CONTROL    15     19.1    1.9         9     32.8    1.3                      9     14.1    1.6

 3125 PPM           15     19.2    2.1        12     31.3    2.5        95.4         12     11.5    1.9

 6250 PPM           15     19.1    1.8         8     32.1    2.3        97.8          8     13.3    2.8

 12500   PPM        15     17.8    2.2        12     31.2    2.3        95.1         12     13.3    3.0

 25000   PPM        15     19.1    2.0        11     31.2    3.5        95.1         11     12.2    3.7

 50000   PPM        15     18.6    1.7        10     31.7    1.9        96.6         10     12.6    1.6

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                                               ---------- END-OF-REPORT ----------
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