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TDMS Study 99033-01 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: BIORELIANCE                           TRANSGENIC MODEL EVALUATION II (ASPARTAME)                               DATE: 03/05/03  
EXPERIMENT: 99033 TEST: 01                                                                                        TIME: 13:36:34    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: DOSED FEED                                             NTP:  C99033      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        FINAL #3 TG.AC MICE                                                         
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    VEHICLE CONTROL                                                               
                                       INCLUDE 002    3125 PPM                                                                      
                                       INCLUDE 003    6250 PPM                                                                      
                                       INCLUDE 004    12500   PPM                                                                   
                                       INCLUDE 005    25000   PPM                                                                   
                                       INCLUDE 006    50000   PPM                                                                   
                                       INCLUDE 008    VEHICLE CONTROL                                                               
                                       INCLUDE 009    3125 PPM                                                                      
                                       INCLUDE 010    6250 PPM                                                                      
                                       INCLUDE 011    12500   PPM                                                                   
                                       INCLUDE 012    25000   PPM                                                                   
                                       INCLUDE 013    50000   PPM                                                                   
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BIORELIANCE                                      TRANSGENIC MODEL EVALUATION II (ASPARTAME)                  DATE: 03/05/03    
EXPERIMENT: 99033 TEST: 01                                                                                        TIME: 13:45:21    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: 26                                       ROUTE: DOSED FEED                                             NTP:  C99033      
CONT: N01-ES-65406                                                                                                CAS: 22839-47-0   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                                   26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                
==================================================================================================================================  
      VEHICLE CONTROL                 3125 PPM                           6250 PPM                         12500   PPM               
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.5    21.5       4.2     21.3    0.93      615      4.2     20.1    0.93     1304      4.3     20.3    0.96     2631       
  3     4.1    21.9       4.0     22.0    0.98      572      4.4     21.8    1.07     1267      4.3     21.2    1.05     2510       
  4     4.5    22.6       4.5     23.2    1.00      601      4.4     22.7    0.98     1204      4.3     22.3    0.96     2432       
  5     4.5    23.8       4.3     23.7    0.96      570      4.5     23.6    1.00     1190      4.3     23.1    0.96     2312       
  6     4.2    24.6       4.1     23.2    0.98      552      4.4     24.6    1.05     1129      4.2     23.5    1.00     2244       
  7     4.5    25.2       4.2     24.8    0.93      531      4.4     25.7    0.98     1081      4.0     23.9    0.89     2075       
  8     4.5    26.0       4.2     25.0    0.93      523      4.3     25.8    0.96     1031      4.2     24.8    0.93     2125       
  9     4.4    26.3       4.3     25.9    0.98      516      4.4     26.8    1.00     1019      4.4     25.6    1.00     2125       
 10     4.3    27.4       4.3     26.4    1.00      513      4.3     26.7    1.00     1007      4.3     26.1    1.00     2059       
 11     4.3    28.2       4.4     26.7    1.02      513      4.5     27.5    1.05     1032      4.6     26.8    1.07     2125       
 12     4.4    28.5       4.1     26.2    0.93      487      4.5     28.0    1.02     1015      4.3     26.6    0.98     2001       
 13     4.3    28.8       4.4     27.4    1.02      496      4.5     28.3    1.05     1006      4.2     27.0    0.98     1923       
 14     4.2    29.0       4.2     27.1    1.00      479      4.2     27.8    1.00      949      4.2     27.2    1.00     1933       
 15     4.2    29.5       4.5     28.5    1.07      490      4.5     29.2    1.07      966      4.2     28.0    1.00     1872       
 16     4.2    29.5       4.1     27.8    0.98      460      4.3     28.8    1.02      928      4.3     27.9    1.02     1923       
 17     4.2    29.2       4.3     27.9    1.02      486      4.3     29.1    1.02      930      4.2     28.3    1.00     1876       
 18     4.1    29.5       4.4     28.6    1.07      478      4.3     29.2    1.05      928      4.3     28.3    1.05     1881       
 19     4.1    29.1       4.4     29.4    1.07      471      4.4     29.7    1.07      926      4.2     28.2    1.02     1845       
 20     4.4    29.7       4.1     29.0    0.93      446      4.1     29.9    0.93      864      4.2     28.6    0.95     1851       
 21     4.3    30.2       4.4     29.6    1.02      469      4.5     30.3    1.05      921      4.3     29.0    1.00     1874       
 22     4.2    30.4       4.2     29.1    1.00      447      4.0     29.7    0.95      847      4.3     29.0    1.02     1873       
 23     4.3    30.8       4.2     29.1    0.98      450      4.5     29.9    1.05      948      4.4     29.2    1.02     1892       
 24     4.2    30.7       4.2     28.8    1.00      451      4.2     30.1    1.00      877      4.3     29.9    1.02     1780       
 25     4.4    31.1       4.3     29.1    0.98      461      4.3     30.5    0.98      890      4.5     30.0    1.02     1856       
 26     4.0    30.8       4.3     29.4    1.08      460      4.4     30.7    1.10      902      4.2     30.0    1.05     1758       
 27     4.3    31.3       4.4     29.4    1.02      466      4.2     30.7    0.98      861      4.1     29.7    0.95     1738       
 28     4.1    31.5       4.3     29.3    1.05      458      4.2     30.5    1.02      869      4.2     29.7    1.02     1785       
 29     4.2    31.4       4.2     28.8    1.00      460      4.0     30.0    0.95      840      4.1     30.1    0.98     1719       
 30     4.4    31.8       4.6     30.2    1.05      472      4.5     30.0    1.02      931      4.4     30.7    1.00     1779       
 31     4.5    31.5       4.6     30.4    1.02      471      4.7     30.6    1.04      968      4.6     30.5    1.02     1869       
 32     4.3    31.1       4.6     30.6    1.07      470      4.8     30.9    1.12      961      4.4     30.1    1.02     1830       
 33     4.4    31.1       4.8     30.6    1.09      494      4.7     30.8    1.07      960      4.6     30.0    1.05     1918       
 34     4.5    31.3       4.7     30.5    1.04      482      4.6     31.2    1.02      925      4.8     30.3    1.07     1965       
 35     4.5    31.6       4.6     30.6    1.02      470      4.6     30.7    1.02      928      4.7     30.8    1.04     1914       
 36     4.6    32.0       4.6     30.6    1.00      467      4.8     31.7    1.04      952      4.8     31.3    1.04     1896       
 37     4.4    32.0       4.5     30.1    1.02      464      4.7     31.9    1.07      918      4.5     30.9    1.02     1832       
 38     4.3    31.7       4.7     30.9    1.09      475      4.4     31.6    1.02      878      4.3     31.2    1.00     1739       
 39     4.2    31.8       4.6     31.1    1.10      461      4.6     31.8    1.10      898      4.5     31.3    1.07     1796       
 40     4.4    32.8       4.3     31.3    0.98      428      4.7     32.1    1.07      907      4.5     31.2    1.02     1802       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.4    25.4       4.2     24.7    0.97      541      4.4     25.1    1.01     1107      4.3     24.3    0.98     2214       
SD(D)   0.1               0.1             0.03       41      0.1             0.04      109      0.1             0.05      217       
CV(E)   2.9               3.1             3.6       7.6      2.7             4.2       9.8      3.2             5.0       9.8       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.3    30.8       4.4     29.5    1.03      466      4.4     30.3    1.03      914      4.4     29.7    1.02     1844       
SD(D)   0.1               0.2             0.04       14      0.2             0.05       37      0.2             0.03       65       
CV(E)   3.5               4.5             4.2       3.1      5.0             4.5       4.1      4.2             2.8       3.5       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                    
         26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                          
=============================================================================                                                       
                  25000   PPM                        50000   PPM                                                                    
       ---------------------------------  ---------------------------------                                                         
                         DOSE/                              DOSE/                                                                   
       GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL                                                                  
       FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/                                                         
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                         
=============================================================================                                                       
  2     4.3     21.7     0.96    5005      4.1     20.8     0.91    9871                                                            
  3     4.4     22.1     1.07    4998      4.2     22.0     1.02    9590                                                            
  4     4.5     23.3     1.00    4808      4.3     22.7     0.96    9448                                                            
  5     4.4     23.9     0.98    4642      4.3     23.6     0.96    9028                                                            
  6     4.5     25.0     1.07    4540      4.1     23.8     0.98    8695                                                            
  7     4.4     25.4     0.98    4375      4.2     24.9     0.93    8394                                                            
  8     4.5     25.9     1.00    4332      4.1     24.6     0.91    8247                                                            
  9     4.3     26.1     0.98    4168      4.3     25.5     0.98    8340                                                            
 10     4.3     26.4     1.00    4027      4.3     26.2     1.00    8210                                                            
 11     4.5     27.5     1.05    4056      4.4     26.8     1.02    8178                                                            
 12     4.2     26.7     0.95    3968      4.3     27.0     0.98    8059                                                            
 13     4.7     27.9     1.09    4170      4.4     27.4     1.02    7993                                                            
 14     4.5     28.1     1.07    3985      4.4     27.6     1.05    7958                                                            
 15     4.4     28.5     1.05    3876      4.2     28.1     1.00    7465                                                            
 16     4.4     28.4     1.05    3841      4.1     27.8     0.98    7396                                                            
 17     4.5     29.0     1.07    3879      4.2     28.6     1.00    7348                                                            
 18     4.4     28.8     1.07    3779      4.2     28.6     1.02    7423                                                            
 19     4.5     29.3     1.10    3840      4.3     28.4     1.05    7611                                                            
 20     4.2     29.9     0.95    3479      4.1     28.9     0.93    7128                                                            
 21     4.2     29.6     0.98    3584      4.2     29.4     0.98    7092                                                            
 22     4.4     29.4     1.05    3724      3.9     28.5     0.93    6829                                                            
 23     4.5     29.7     1.05    3766      4.2     28.4     0.98    7373                                                            
 24     4.4     30.0     1.05    3635      4.4     27.9     1.05    7866                                                            
 25     4.5     29.6     1.02    3820      4.0     28.0     0.91    7176                                                            
 26     4.5     30.3     1.13    3724      4.0     27.2     1.00    7385                                                            
 27     4.5     30.5     1.05    3668      4.1     29.0     0.95    7075                                                            
 28     4.6     30.7     1.12    3713      4.2     29.7     1.02    7085                                                            
 29     4.5     30.9     1.07    3622      4.1     30.0     0.98    6796                                                            
 30     4.6     31.1     1.05    3669      4.3     30.9     0.98    6998                                                            
 31     4.8     31.0     1.07    3854      4.6     30.9     1.02    7479                                                            
 32     4.7     31.3     1.09    3756      4.3     31.0     1.00    6938                                                            
 33     4.5     31.1     1.02    3591      4.5     31.2     1.02    7174                                                            
 34     4.8     30.8     1.07    3862      4.3     30.5     0.96    7085                                                            
 35     4.4     30.3     0.98    3603      4.3     31.1     0.96    6951                                                            
 36     4.4     29.8     0.96    3704      4.5     31.6     0.98    7044                                                            
 37     4.2     29.7     0.95    3536      4.2     31.2     0.95    6662                                                            
 38     4.7     30.3     1.09    3881      4.2     31.3     0.98    6790                                                            
 39     4.8     31.7     1.14    3817      4.1     31.2     0.98    6564                                                            
 40     4.6     31.2     1.05    3667      4.5     31.7     1.02    7023                                                            
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.4     25.2     1.01    4424      4.2     24.6     0.97    8671                                                            
SD(D)   0.1              0.05     371      0.1              0.04     652                                                            
CV(E)   2.7              4.8      8.4      2.5              4.2      7.5                                                            
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.5     30.0     1.05    3736      4.2     29.6     0.99    7175                                                            
SD(D)   0.2              0.05     124      0.2              0.04     336                                                            
CV(E)   3.7              4.8      3.3      3.9              3.8      4.7                                                            
=============================================================================                                                       
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                                   26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                
==================================================================================================================================  
      VEHICLE CONTROL                 3125 PPM                           6250 PPM                         12500   PPM               
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.2    18.1       4.2     18.0     1.00     724      4.1     17.7     0.98    1432      4.1     17.4     0.98    2918       
  3     4.0    18.5       4.1     18.9     1.03     682      3.8     18.3     0.95    1285      3.8     17.8     0.95    2649       
  4     4.5    19.5       4.2     19.7     0.93     669      4.1     19.5     0.91    1306      4.0     18.8     0.89    2643       
  5     4.1    19.5       4.0     20.1     0.98     618      3.8     19.7     0.93    1206      3.9     19.7     0.95    2488       
  6     4.2    19.7       4.1     20.3     0.98     634      4.1     20.4     0.98    1269      4.1     19.3     0.98    2658       
  7     4.1    20.1       4.0     21.4     0.98     581      3.9     21.3     0.95    1155      4.1     20.7     1.00    2458       
  8     4.1    20.5       3.8     20.9     0.93     566      3.7     20.6     0.90    1118      4.0     20.6     0.98    2404       
  9     4.2    21.1       4.0     21.9     0.95     570      3.9     21.5     0.93    1134      4.1     21.3     0.98    2397       
 10     4.0    21.6       4.1     22.2     1.03     574      4.0     21.5     1.00    1156      4.1     21.9     1.03    2327       
 11     3.8    21.7       4.0     22.4     1.05     559      4.2     22.5     1.11    1165      4.0     21.9     1.05    2308       
 12     4.1    22.4       4.1     22.6     1.00     561      4.1     21.9     1.00    1166      4.1     21.9     1.00    2326       
 13     4.1    22.5       4.1     22.6     1.00     568      3.9     22.0     0.95    1117      4.2     22.3     1.02    2372       
 14     4.0    22.4       4.1     22.9     1.03     564      4.3     23.0     1.08    1158      4.1     22.5     1.03    2257       
 15     3.7    22.3       3.6     22.5     0.97     494      3.9     23.3     1.05    1057      4.1     22.4     1.11    2283       
 16     3.8    22.6       4.2     23.3     1.11     567      4.0     23.4     1.05    1056      4.0     22.5     1.05    2224       
 17     4.0    22.6       3.9     23.1     0.98     528      3.8     23.2     0.95    1027      4.1     22.5     1.03    2263       
 18     4.0    22.6       4.1     23.3     1.03     544      4.2     23.4     1.05    1112      4.1     22.9     1.03    2228       
 19     3.8    23.0       4.0     23.3     1.05     537      4.2     23.8     1.11    1110      4.1     23.4     1.08    2188       
 20     4.0    23.1       3.9     23.1     0.98     523      3.9     23.7     0.98    1024      3.8     23.0     0.95    2090       
 21     4.1    23.9       4.1     24.2     1.00     535      4.3     24.7     1.05    1084      3.9     23.3     0.95    2065       
 22     4.1    23.7       4.1     24.3     1.00     527      4.3     24.6     1.05    1088      3.9     22.9     0.95    2147       
 23     4.6    24.4       4.0     24.6     0.87     513      4.2     24.6     0.91    1068      4.1     23.1     0.89    2222       
 24     4.3    24.4       4.0     24.1     0.93     515      4.1     24.8     0.95    1044      3.8     23.1     0.88    2033       
 25     4.0    24.4       4.2     25.2     1.05     525      4.2     25.0     1.05    1037      4.0     24.0     1.00    2071       
 26     4.3    24.9       4.0     25.6     0.93     492      4.2     25.0     0.98    1053      4.4     23.9     1.02    2281       
 27     4.2    25.1       4.1     25.6     0.98     498      3.9     24.9     0.93     969      4.0     23.5     0.95    2126       
 28     4.0    25.3       3.8     25.2     0.95     475      4.3     25.1     1.08    1061      4.2     25.0     1.05    2107       
 29     4.2    25.3       3.9     25.4     0.93     479      3.8     24.9     0.90     955      3.8     24.9     0.90    1928       
 30     4.6    26.0       3.8     25.0     0.83     481      4.3     25.6     0.93    1039      4.5     25.4     0.98    2209       
 31     4.5    25.8       4.2     25.1     0.93     526      4.5     26.3     1.00    1065      4.3     25.1     0.96    2139       
 32     4.4    25.1       4.4     25.1     1.00     544      4.3     26.1     0.98    1036      4.6     25.3     1.05    2246       
 33     4.3    25.6       4.4     25.1     1.02     554      4.6     26.4     1.07    1091      4.4     25.0     1.02    2219       
 34     4.3    25.6       4.6     25.1     1.07     573      4.8     26.6     1.12    1132      4.5     25.4     1.05    2202       
 35     4.1    25.4       4.5     26.0     1.10     540      4.3     26.9     1.05    1007      4.4     26.1     1.07    2115       
 36     4.6    26.1       4.2     25.7     0.91     512      4.4     27.8     0.96     998      4.3     26.3     0.93    2026       
 37     4.4    25.9       3.8     25.4     0.86     472      4.3     27.6     0.98     982      4.3     25.8     0.98    2064       
 38     4.5    26.2       4.3     26.2     0.96     507      4.1     27.0     0.91     945      4.2     26.0     0.93    2000       
 39     4.3    26.5       4.0     26.4     0.93     474      4.1     27.6     0.95     932      4.3     26.4     1.00    2025       
 40     4.3    26.7       4.1     25.4     0.95     500      4.3     26.9     1.00    1000      4.4     26.5     1.02    2055       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.1    20.4       4.1     20.9     0.99     609      4.0     20.6     0.96    1209      4.0     20.3     0.98    2496       
SD(D)   0.2               0.1              0.04      56      0.2              0.05      95      0.1              0.04     185       
CV(E)   4.0               2.9              3.8      9.3      3.9              5.6      7.9      2.8              4.3      7.4       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.2    24.6       4.1     24.7     0.98     518      4.2     25.3     1.00    1042      4.2     24.3     0.99    2141       
SD(D)   0.2               0.2              0.07      30      0.2              0.06      56      0.2              0.06      98       
CV(E)   5.8               5.6              7.0      5.7      5.6              6.3      5.4      5.3              6.0      4.6       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                  
         26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                          
=============================================================================                                                       
                  25000   PPM                        50000   PPM                                                                    
       ---------------------------------  ---------------------------------                                                         
                         DOSE/                              DOSE/                                                                   
       GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL                                                                  
       FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/                                                         
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                         
=============================================================================                                                       
  2     4.2     18.1     1.00    5774      3.9     17.8     0.93   10879                                                            
  3     3.8     17.6     0.95    5388      3.8     17.9     0.95   10617                                                            
  4     4.1     19.6     0.91    5255      4.0     19.6     0.89   10200                                                            
  5     3.9     20.1     0.95    4804      3.8     20.3     0.93    9293                                                            
  6     3.6     20.2     0.86    4408      3.8     20.2     0.90    9351                                                            
  7     4.1     20.8     1.00    4911      3.8     21.3     0.93    9017                                                            
  8     4.1     21.1     1.00    4848      3.6     20.7     0.88    8771                                                            
  9     4.0     21.6     0.95    4578      4.0     21.8     0.95    9301                                                            
 10     3.9     21.9     0.98    4461      3.9     22.4     0.98    8760                                                            
 11     3.8     22.5     1.00    4271      3.8     22.7     1.00    8466                                                            
 12     3.8     21.7     0.93    4424      3.9     23.2     0.95    8460                                                            
 13     4.4     23.2     1.07    4737      4.0     23.1     0.98    8756                                                            
 14     4.4     22.9     1.10    4768      4.1     23.1     1.03    8832                                                            
 15     4.2     23.6     1.14    4495      3.8     23.5     1.03    8133                                                            
 16     3.9     23.4     1.03    4183      4.2     24.5     1.11    8461                                                            
 17     4.1     23.8     1.03    4262      3.9     24.4     0.98    7892                                                            
 18     4.1     23.7     1.03    4273      3.9     24.5     0.98    8036                                                            
 19     4.1     23.6     1.08    4320      4.2     24.9     1.11    8436                                                            
 20     4.1     23.7     1.03    4302      4.0     25.9     1.00    7669                                                            
 21     4.0     24.1     0.98    4152      3.9     26.0     0.95    7512                                                            
 22     4.2     24.2     1.02    4328      3.8     25.7     0.93    7319                                                            
 23     4.1     23.9     0.89    4301      4.1     25.7     0.89    7991                                                            
 24     4.1     24.3     0.95    4212      4.3     26.1     1.00    8163                                                            
 25     4.1     24.4     1.03    4190      3.9     26.2     0.98    7483                                                            
 26     4.4     24.7     1.02    4439      3.8     26.1     0.88    7339                                                            
 27     4.1     24.9     0.98    4145      3.8     26.3     0.90    7318                                                            
 28     4.2     25.1     1.05    4151      3.9     27.3     0.98    7214                                                            
 29     4.1     25.0     0.98    4140      3.9     27.5     0.93    7156                                                            
 30     4.1     24.8     0.89    4119      3.9     27.2     0.85    7180                                                            
 31     4.1     24.4     0.91    4220      4.2     27.9     0.93    7521                                                            
 32     4.2     24.3     0.95    4370      4.1     28.0     0.93    7251                                                            
 33     4.2     24.6     0.98    4282      4.3     27.8     1.00    7671                                                            
 34     4.2     24.7     0.98    4243      4.1     27.9     0.95    7433                                                            
 35     4.4     25.3     1.07    4292      4.1     27.7     1.00    7364                                                            
 36     3.8     25.0     0.83    3827      3.9     27.8     0.85    7086                                                            
 37     3.8     24.7     0.86    3866      4.1     27.2     0.93    7545                                                            
 38     3.9     24.6     0.87    3959      4.2     28.1     0.93    7425                                                            
 39     4.0     24.8     0.93    4042      4.0     28.0     0.93    7132                                                            
 40     4.4     26.5     1.02    4195      4.2     28.3     0.98    7456                                                            
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.0     20.7     0.97    4822      3.9     20.9     0.94    9323                                                            
SD(D)   0.2              0.05     453      0.1              0.04     819                                                            
CV(E)   5.5              5.7      9.4      3.2              3.9      8.8                                                            
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.1     24.4     0.99    4225      4.0     26.4     0.96    7630                                                            
SD(D)   0.2              0.08     187      0.1              0.06     460                                                            
CV(E)   3.8              7.7      4.4      3.7              6.6      6.0                                                            
=============================================================================                                                       
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                 
                                  26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                 
==================================================================================================================================  
      VEHICLE CONTROL              3125 PPM                 6250 PPM               12500   PPM              25000   PPM             
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               19.1  15                 19.2  15                 19.1  15                 17.8  15                 19.1  15      
  1               19.1  15                 19.2  15                 19.1  15                 17.8  15                 19.1  15      
  2   4.5  2490   21.5  15     4.2  2498   21.3  15     4.2  2505   20.1  15     4.3  2505   20.3  15     4.3  2505   21.7  15      
  3   4.1  2498   21.9  15     4.0  2490   22.0  15     4.4  2505   21.8  15     4.3  2505   21.2  15     4.4  2505   22.1  15      
  4   4.5  2520   22.6  15     4.5  2520   23.2  15     4.4  2505   22.7  15     4.3  2505   22.3  15     4.5  2505   23.3  15      
  5   4.5  2520   23.8  15     4.3  2520   23.7  15     4.5  2505   23.6  15     4.3  2505   23.1  15     4.4  2505   23.9  15      
  6   4.2  2550   24.6  15     4.1  2550   23.2  15     4.4  2550   24.6  15     4.2  2550   23.5  15     4.5  2550   25.0  15      
  7   4.5  2475   25.2  15     4.2  2475   24.8  15     4.4  2475   25.7  15     4.0  2490   23.9  15     4.4  2490   25.4  15      
  8   4.5  2520   26.0  15     4.2  2520   25.0  15     4.3  2520   25.8  15     4.2  2520   24.8  15     4.5  2520   25.9  15      
  9   4.4  2535   26.3  15     4.3  2535   25.9  15     4.4  2535   26.8  15     4.4  2535   25.6  15     4.3  2524   26.1  15      
 10   4.3  2505   27.4  15     4.3  2520   26.4  15     4.3  2520   26.7  15     4.3  2520   26.1  15     4.3  2475   26.4  15      
 11   4.3  2520   28.2  15     4.4  2505   26.7  15     4.5  2490   27.5  15     4.6  2478   26.8  15     4.5  2520   27.5  15      
 12   4.4  2352   28.5  14     4.1  2352   26.2  15     4.5  2352   28.0  14     4.3  2535   26.6  15     4.2  2531   26.7  15      
 13   4.3  2338   28.8  14     4.4  2340   27.4  15     4.5  2347   28.3  14     4.2  2505   27.0  15     4.7  2509   27.9  15      
 14   4.2  2358   29.0  14     4.2  2565   27.1  15     4.2  2380   27.8  14     4.2  2550   27.2  15     4.5  2520   28.1  15      
 15   4.2  2352   29.5  14     4.5  2505   28.5  15     4.5  2352   29.2  14     4.2  2520   28.0  15     4.4  2352   28.5  14      
 16   4.2  2352   29.5  14     4.1  2520   27.8  15     4.3  2352   28.8  14     4.3  2526   27.9  15     4.4  2352   28.4  14      
 17   4.2  2397   29.2  14     4.3  2505   27.9  15     4.3  2338   29.1  14     4.2  2505   28.3  15     4.5  2380   29.0  14      
 18   4.1  2352   29.5  14     4.4  2505   28.6  15     4.3  2338   29.2  14     4.3  2505   28.3  15     4.4  2352   28.8  14      
 19   4.1  2310   29.1  14     4.4  2535   29.4  15     4.4  2370   29.7  14     4.2  2550   28.2  15     4.5  2366   29.3  14      
 20   4.4  2352   29.7  14     4.1  2520   29.0  15     4.1  2184   29.9  13     4.2  2505   28.6  15     4.2  2338   29.9  14      
 21   4.3  2352   30.2  14     4.4  2535   29.6  15     4.5  2040   30.3  12     4.3  2535   29.0  15     4.2  2158   29.6  13      
 22   4.2  2338   30.4  14     4.2  2520   29.1  15     4.0  2004   29.7  12     4.3  2520   29.0  15     4.4  2182   29.4  13      
 23   4.3  2352   30.8  14     4.2  2520   29.1  15     4.5  1848   29.9  11     4.4  2520   29.2  15     4.5  2184   29.7  13      
 24   4.2  2353   30.7  14     4.2  2531   28.8  15     4.2  1848   30.1  11     4.3  2526   29.9  15     4.4  2184   30.0  13      
 25   4.4  2351   31.1  14     4.3  2520   29.1  15     4.3  1848   30.5  11     4.5  2505   30.0  15     4.5  2184   29.6  13      
 26   4.0  2352   30.8  14     4.3  2520   29.4  15     4.4  1848   30.7  11     4.2  2520   30.0  15     4.5  2184   30.3  13      
 27   4.3  2184   31.3  13     4.4  2520   29.4  15     4.2  1859   30.7  11     4.1  2535   29.7  15     4.5  2184   30.5  13      
 28   4.1  2184   31.5  13     4.3  2535   29.3  15     4.2  1826   30.5  11     4.2  2503   29.7  15     4.6  2184   30.7  13      
 29   4.2  2016   31.4  12     4.2  2535   28.8  15     4.0  1690   30.0  10     4.1  2535   30.1  15     4.5  2184   30.9  13      
 30   4.4  2016   31.8  12     4.6  2310   30.2  14     4.5  1677   30.0  10     4.4  2338   30.7  14     4.6  2184   31.1  13      
 31   4.5  2028   31.5  12     4.6  2352   30.4  14     4.7  1512   30.6   9     4.6  2171   30.5  13     4.8  2176   31.0  13      
 32   4.3  2019   31.1  12     4.6  2367   30.6  14     4.8  1521   30.9   9     4.4  2197   30.1  13     4.7  2184   31.3  13      
 33   4.4  2004   31.1  12     4.8  2350   30.6  14     4.7  1512   30.8   9     4.6  2184   30.0  13     4.5  2184   31.1  13      
 34   4.5  2028   31.3  12     4.7  2366   30.5  14     4.6  1521   31.2   9     4.8  2197   30.3  13     4.8  2197   30.8  13      
 35   4.5  2007   31.6  12     4.6  2338   30.6  14     4.6  1503   30.7   9     4.7  2009   30.8  13     4.4  2216   30.3  13      
 36   4.6  2016   32.0  12     4.6  2380   30.6  14     4.8  1512   31.7   9     4.8  2184   31.3  13     4.4  1980   29.8  12      
 37   4.4  2016   32.0  12     4.5  2324   30.1  14     4.7  1503   31.9   9     4.5  2171   30.9  13     4.2  2028   29.7  12      
 38   4.3  2016   31.7  12     4.7  2379   30.9  14     4.4  1530   31.6   9     4.3  2223   31.2  13     4.7  1845   30.3  12      
 39   4.2  2016   31.8  12     4.6  2353   31.1  14     4.6  1494   31.8   9     4.5  2158   31.3  13     4.8  1840   31.7  11      
 40   4.4  1512   32.8   9     4.3  1980   31.3  12     4.7  1328   32.1   8     4.5  1992   31.2  12     4.6  1848   31.2  11      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           24.9                     24.2                     24.7                     23.8                     24.7          
14 TO 52          30.8                     29.5                     30.3                     29.7                     30.0          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
DIAGNOSTIC TRAILER REPORT                                                                                                           
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                                   
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                   
==============================                                                                                                      
        50000   PPM                                                                                                                 
     ----------------------                                                                                                         
     DAILY FEED  BODY  NUM                                                                                                          
WEEK FEED HOURS   WGT  WGTS                                                                                                         
===============================                                                                                                     
  B               18.6  15                                                                                                          
  1               18.6  15                                                                                                          
  2   4.1  2511   20.8  15                                                                                                          
  3   4.2  2505   22.0  15                                                                                                          
  4   4.3  2505   22.7  15                                                                                                          
  5   4.3  2493   23.6  15                                                                                                          
  6   4.1  2550   23.8  15                                                                                                          
  7   4.2  2490   24.9  15                                                                                                          
  8   4.1  2520   24.6  15                                                                                                          
  9   4.3  2520   25.5  15                                                                                                          
 10   4.3  2475   26.2  15                                                                                                          
 11   4.4  2520   26.8  15                                                                                                          
 12   4.3  2535   27.0  15                                                                                                          
 13   4.4  2505   27.4  15                                                                                                          
 14   4.4  2535   27.6  15                                                                                                          
 15   4.2  2520   28.1  15                                                                                                          
 16   4.1  2520   27.8  15                                                                                                          
 17   4.2  2550   28.6  15                                                                                                          
 18   4.2  2520   28.6  15                                                                                                          
 19   4.3  2535   28.4  15                                                                                                          
 20   4.1  2505   28.9  15                                                                                                          
 21   4.2  2324   29.4  14                                                                                                          
 22   3.9  2352   28.5  14                                                                                                          
 23   4.2  2352   28.4  14                                                                                                          
 24   4.4  2356   27.9  14                                                                                                          
 25   4.0  2352   28.0  14                                                                                                          
 26   4.0  2352   27.2  14                                                                                                          
 27   4.1  2016   29.0  12                                                                                                          
 28   4.2  2016   29.7  12                                                                                                          
 29   4.1  2016   30.0  12                                                                                                          
 30   4.3  1848   30.9  11                                                                                                          
 31   4.6  1848   30.9  11                                                                                                          
 32   4.3  1859   31.0  11                                                                                                          
 33   4.5  1848   31.2  11                                                                                                          
 34   4.3  1859   30.5  11                                                                                                          
 35   4.3  1881   31.1  11                                                                                                          
 36   4.5  1815   31.6  11                                                                                                          
 37   4.2  1848   31.2  11                                                                                                          
 38   4.2  1853   31.3  11                                                                                                          
 39   4.1  1837   31.2  11                                                                                                          
 40   4.5  1670   31.7  10                                                                                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           24.1                                                                                                              
14 TO 52          29.6                                                                                                              
==============================                                                                                                      
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                                  DIAGNOSTIC TRAILER REPORT                                                                         
                                  FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                               
                                  26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                 
==================================================================================================================================  
      VEHICLE CONTROL              3125 PPM                 6250 PPM               12500   PPM              25000   PPM             
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               16.6  15                 16.6  15                 15.8  15                 15.5  15                 16.4  15      
  1               16.6  15                 16.6  15                 15.8  15                 15.5  15                 16.4  15      
  2   4.2  2490   18.1  15     4.2  2505   18.0  15     4.1  2505   17.7  15     4.1  2505   17.4  15     4.2  2507   18.1  15      
  3   4.0  2490   18.5  15     4.1  2490   18.9  15     3.8  2505   18.3  15     3.8  2505   17.8  15     3.8  2504   17.6  15      
  4   4.5  2520   19.5  15     4.2  2520   19.7  15     4.1  2505   19.5  15     4.0  2505   18.8  15     4.1  2505   19.6  15      
  5   4.1  2520   19.5  15     4.0  2520   20.1  15     3.8  2505   19.7  15     3.9  2505   19.7  15     3.9  2338   20.1  14      
  6   4.2  2550   19.7  15     4.1  2550   20.3  15     4.1  2550   20.4  15     4.1  2550   19.3  15     3.6  2210   20.2  14      
  7   4.1  2475   20.1  15     4.0  2475   21.4  15     3.9  2490   21.3  15     4.1  2490   20.7  15     4.1  2324   20.8  14      
  8   4.1  2520   20.5  15     3.8  2520   20.9  15     3.7  2520   20.6  15     4.0  2520   20.6  15     4.1  2352   21.1  14      
  9   4.2  2535   21.1  15     4.0  2535   21.9  15     3.9  2535   21.5  15     4.1  2535   21.3  15     4.0  2352   21.6  14      
 10   4.0  2505   21.6  15     4.1  2520   22.2  15     4.0  2352   21.5  14     4.1  2520   21.9  15     3.9  2310   21.9  14      
 11   3.8  2520   21.7  15     4.0  2491   22.4  15     4.2  2158   22.5  13     4.0  2475   21.9  15     3.8  2352   22.5  14      
 12   4.1  2520   22.4  15     4.1  2520   22.6  15     4.1  2187   21.9  13     4.1  2533   21.9  15     3.8  2366   21.7  14      
 13   4.1  2505   22.5  15     4.1  2349   22.6  14     3.9  2181   22.0  13     4.2  2507   22.3  15     4.4  2338   23.2  14      
 14   4.0  2535   22.4  15     4.1  2394   22.9  14     4.3  2210   23.0  13     4.1  2550   22.5  15     4.4  2356   22.9  14      
 15   3.7  2520   22.3  15     3.6  2338   22.5  14     3.9  2184   23.3  13     4.1  2352   22.4  14     4.2  2352   23.6  14      
 16   3.8  2520   22.6  15     4.2  2352   23.3  14     4.0  2184   23.4  13     4.0  2366   22.5  14     3.9  2352   23.4  14      
 17   4.0  2404   22.6  14     3.9  2338   23.1  14     3.8  2004   23.2  12     4.1  2338   22.5  14     4.1  2380   23.8  14      
 18   4.0  2352   22.6  14     4.1  2338   23.3  14     4.2  2004   23.4  12     4.1  2338   22.9  14     4.1  2352   23.7  14      
 19   3.8  2310   23.0  14     4.0  2366   23.3  14     4.2  2028   23.8  12     4.1  2380   23.4  14     4.1  2366   23.6  14      
 20   4.0  2352   23.1  14     3.9  2352   23.1  14     3.9  2016   23.7  12     3.8  2171   23.0  13     4.1  2338   23.7  14      
 21   4.1  2352   23.9  14     4.1  2366   24.2  14     4.3  2040   24.7  12     3.9  2197   23.3  13     4.0  2324   24.1  14      
 22   4.1  2338   23.7  14     4.1  2352   24.3  14     4.3  1837   24.6  11     3.9  2184   22.9  13     4.2  2352   24.2  14      
 23   4.6  2352   24.4  14     4.0  2352   24.6  14     4.2  1848   24.6  11     4.1  2184   23.1  13     4.1  2352   23.9  14      
 24   4.3  2352   24.4  14     4.0  2366   24.1  14     4.1  1848   24.8  11     3.8  2184   23.1  13     4.1  2352   24.3  14      
 25   4.0  2352   24.4  14     4.2  2352   25.2  14     4.2  1848   25.0  11     4.0  1837   24.0  11     4.1  2352   24.4  14      
 26   4.3  2352   24.9  14     4.0  2352   25.6  14     4.2  1848   25.0  11     4.4  1848   23.9  11     4.4  2352   24.7  14      
 27   4.2  2352   25.1  14     4.1  2357   25.6  14     3.9  1859   24.9  11     4.0  1859   23.5  11     4.1  2352   24.9  14      
 28   4.0  2352   25.3  14     3.8  2364   25.2  14     4.3  1826   25.1  11     4.2  1660   25.0  10     4.2  2352   25.1  14      
 29   4.2  2352   25.3  14     3.9  2197   25.4  13     3.8  1859   24.9  11     3.8  1690   24.9  10     4.1  2352   25.0  14      
 30   4.6  2184   26.0  13     3.8  1980   25.0  12     4.3  1680   25.6  10     4.5  1670   25.4  10     4.1  2352   24.8  14      
 31   4.5  2197   25.8  13     4.2  1848   25.1  11     4.5  1511   26.3   9     4.3  1670   25.1  10     4.1  2341   24.4  14      
 32   4.4  2197   25.1  13     4.4  1859   25.1  11     4.3  1521   26.1   9     4.6  1690   25.3  10     4.2  2350   24.3  14      
 33   4.3  2171   25.6  13     4.4  1848   25.1  11     4.6  1512   26.4   9     4.4  1680   25.0  10     4.2  2352   24.6  14      
 34   4.3  2197   25.6  13     4.6  1859   25.1  11     4.8  1521   26.6   9     4.5  1690   25.4  10     4.2  2366   24.7  14      
 35   4.1  2184   25.4  13     4.5  1837   26.0  11     4.3  1503   26.9   9     4.4  1680   26.1  10     4.4  2394   25.3  14      
 36   4.6  2016   26.1  12     4.2  1870   25.7  11     4.4  1512   27.8   9     4.3  1680   26.3  10     3.8  2310   25.0  14      
 37   4.4  2032   25.9  12     3.8  1670   25.4  11     4.3  1512   27.6   9     4.3  1680   25.8  10     3.8  2380   24.7  14      
 38   4.5  1992   26.2  12     4.3  1859   26.2  11     4.1  1521   27.0   9     4.2  1690   26.0  10     3.9  2338   24.6  14      
 39   4.3  2016   26.5  12     4.0  1848   26.4  11     4.1  1494   27.6   9     4.3  1660   26.4  10     4.0  2338   24.8  14      
 40   4.3  1864   26.7  11     4.1  1670   25.4  10     4.3  1512   26.9   9     4.4  1512   26.5   9     4.4  1870   26.5  11      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           20.1                     20.6                     20.2                     19.9                     20.4          
14 TO 52          24.6                     24.7                     25.3                     24.3                     24.4          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
DIAGNOSTIC TRAILER REPORT                                                                                                           
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                                 
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                   
==============================                                                                                                      
        50000   PPM                                                                                                                 
     ----------------------                                                                                                         
     DAILY FEED  BODY  NUM                                                                                                          
WEEK FEED HOURS   WGT  WGTS                                                                                                         
===============================                                                                                                     
  B               16.6  15                                                                                                          
  1               16.6  15                                                                                                          
  2   3.9  2520   17.8  15                                                                                                          
  3   3.8  2505   17.9  15                                                                                                          
  4   4.0  2505   19.6  15                                                                                                          
  5   3.8  2490   20.3  15                                                                                                          
  6   3.8  2550   20.2  15                                                                                                          
  7   3.8  2490   21.3  15                                                                                                          
  8   3.6  2520   20.7  15                                                                                                          
  9   4.0  2520   21.8  15                                                                                                          
 10   3.9  2475   22.4  15                                                                                                          
 11   3.8  2516   22.7  15                                                                                                          
 12   3.9  2535   23.2  15                                                                                                          
 13   4.0  2338   23.1  14                                                                                                          
 14   4.1  2028   23.1  12                                                                                                          
 15   3.8  2016   23.5  12                                                                                                          
 16   4.2  2016   24.5  12                                                                                                          
 17   3.9  2040   24.4  12                                                                                                          
 18   3.9  2016   24.5  12                                                                                                          
 19   4.2  2028   24.9  12                                                                                                          
 20   4.0  2004   25.9  12                                                                                                          
 21   3.9  1992   26.0  12                                                                                                          
 22   3.8  2016   25.7  12                                                                                                          
 23   4.1  1848   25.7  11                                                                                                          
 24   4.3  1849   26.1  11                                                                                                          
 25   3.9  1848   26.2  11                                                                                                          
 26   3.8  1848   26.1  11                                                                                                          
 27   3.8  1848   26.3  11                                                                                                          
 28   3.9  1677   27.3  10                                                                                                          
 29   3.9  1680   27.5  10                                                                                                          
 30   3.9  1680   27.2  10                                                                                                          
 31   4.2  1680   27.9  10                                                                                                          
 32   4.1  1521   28.0   9                                                                                                          
 33   4.3  1512   27.8   9                                                                                                          
 34   4.1  1521   27.9   9                                                                                                          
 35   4.1  1539   27.7   9                                                                                                          
 36   3.9  1485   27.8   9                                                                                                          
 37   4.1  1530   27.2   9                                                                                                          
 38   4.2  1503   28.1   9                                                                                                          
 39   4.0  1503   28.0   9                                                                                                          
 40   4.2  1352   28.3   8                                                                                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           20.6                                                                                                              
14 TO 52          26.4                                                                                                              
==============================                                                                                                      
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.