National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6879

TDMS Study 99033-01 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: BIORELIANCE                               TRANSGENIC MODEL EVALUATION II (ASPARTAME)                      DATE: 03/05/03       
EXPERIMENT: 99033 TEST: 01                                                                                     TIME: 11:30:02       
TEST TYPE:  26-39 WEEKS                         CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-65406                              ROUTE: DOSED FEED                                              NTP C#: C99033       
PATHOLOGIST: LANNING, LYNDA                                                                                    CAS: 22839-47-0      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                        FINAL #3 TG.AC MICE                                                         
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    VEHICLE CONTROL                                                               
                                       INCLUDE 002    3125 PPM                                                                      
                                       INCLUDE 003    6250 PPM                                                                      
                                       INCLUDE 004    12500   PPM                                                                   
                                       INCLUDE 005    25000   PPM                                                                   
                                       INCLUDE 006    50000   PPM                                                                   
                                       INCLUDE 008    VEHICLE CONTROL                                                               
                                       INCLUDE 009    3125 PPM                                                                      
                                       INCLUDE 010    6250 PPM                                                                      
                                       INCLUDE 011    12500   PPM                                                                   
                                       INCLUDE 012    25000   PPM                                                                   
                                       INCLUDE 013    50000   PPM                                                                   
                                                                                                                                   
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: BIORELIANCE                               TRANSGENIC MODEL EVALUATION II (ASPARTAME)                      DATE: 03/05/03       
EXPERIMENT: 99033 TEST: 01                                                                                     TIME: 11:30:02       
TEST TYPE:  26-39 WEEKS                         CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-65406                              ROUTE: DOSED FEED                                              NTP C#: C99033       
PATHOLOGIST: LANNING, LYNDA                                                                                    CAS: 22839-47-0      
                                                                                                                                   
                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                      
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 274 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = VEHICLE CONTROL                                |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 9         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      76    183   197   271   271   271                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 3125 PPM                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 3      CENSORED DEATHS 0    TERMINAL 12        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      198   271   271                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 6250 PPM                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 8         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      78    132   138   150   197   207   271                                   |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                      
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 274 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 12500   PPM                              |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 3      CENSORED DEATHS 0    TERMINAL 12        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      199   206   271                                                           |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 25000   PPM                              |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 4      CENSORED DEATHS 0    TERMINAL 11        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      96    138   239   261                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 50000   PPM                              |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 5      CENSORED DEATHS 0    TERMINAL 10        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      141   180   180   200   271                                               |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                      
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 274 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 28    56    84   112   140   168   196   224   252   274 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |VEHICLE    |   100.0 100.0  93.3  93.3  93.3  93.3  86.7  80.0  80.0  60.0      |                                                 
 |CONTROL    |                                                                    |                                                 
 |           |                                                                    |                                                 
 |3125 PPM   |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  93.3  93.3  80.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |6250 PPM   |   100.0 100.0  93.3  93.3  86.7  73.3  73.3  60.0  60.0  53.3      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |12500   PPM|   100.0 100.0 100.0 100.0 100.0 100.0 100.0  86.7  86.7  80.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |25000   PPM|   100.0 100.0 100.0  93.3  93.3  86.7  86.7  86.7  80.0  73.3      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |50000   PPM|   100.0 100.0 100.0 100.0 100.0  93.3  80.0  73.3  73.3  66.7      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                      
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                     MALE MICE                                                                                      
                       FIRST TERMINAL SACRIFICE AT 274 DAYS                                                                         
 ===============================================================================================================================    
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |    
 |                                                                                                                             |    
 |                                                                                                                             |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |                                                                          DOSE                                               |    
 |                                                                                                                             |    
 |                                VEHICLE         3125 PPM        6250 PPM        12500   PPM     25000   PPM     50000   PPM  |    
 |                                CONTROL                                                                                      |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |SURVIVAL AT END OF STUDY|       60.0%           80.0%           53.3%           80.0%           73.3%           66.7%        |    
 |(KAPLAN-MEIER)          |                                                                                                    |    
 |                        |                                                                                                    |    
 |SIGNIFICANCE (B)        |       P=1.000N        P=0.362N        P=0.768         P=0.399N        P=0.771N        P=1.000N     |    
 |(LIFE TABLE)            |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN DAY OF             |       211.5           246.7           167.6           225.3           183.5           194.4        |    
 |NATURAL DEATHS (C)      |       (31.6)          (24.3)          (23.7)          (22.9)          (39.6)          (21.4)       |    
 |(STANDARD ERROR)        |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN LIFE SPAN (D)      |       249.0           268.5           224.3           264.3           249.9           247.5        |    
 |(STANDARD ERROR)        |       (14.5)          ( 5.0)          (17.7)          ( 6.5)          (14.3)          (12.0)       |    
 |                        |                                                                                                    |    
 ===============================================================================================================================    
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                      
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                          DOSE = VEHICLE CONTROL                                |                                                 
 |                       ----------------------------                             |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 4      CENSORED DEATHS 0    TERMINAL 11        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      109   200   242   270                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 3125 PPM                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 5      CENSORED DEATHS 0    TERMINAL 10        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      81    192   198   206   271                                               |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 6250 PPM                                 |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 9         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      61    67    113   148   200   207                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                      
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
                                                                                                                                    
                          INDIVIDUAL SURVIVAL TIMES (DAYS)                                                                          
 ==================================================================================                                                 
 |                                DOSE = 12500   PPM                              |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 9         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      97    134   165   165   184   271                                         |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 25000   PPM                              |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 4      CENSORED DEATHS 0    TERMINAL 11        |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      23    267   269   270                                                     |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |                                DOSE = 50000   PPM                              |                                                 
 |                             ---------------------                              |                                                 
 |                                                                                |                                                 
 |  TOTAL 15     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 8         |                                                 
 |                                                                                |                                                 
 |  UNCENSORED DEATHS                                                             |                                                 
 |      79    92    92    151   184   215   269                                   |                                                 
 |  CENSORED DEATHS                                                               |                                                 
 |      NONE                                                                      |                                                 
 |                                                                                |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                      
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
 ==================================================================================                                                 
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |    DOSE                               TIME (DAYS)                              |                                                 
 |                 28    56    84   112   140   168   196   224   252   275 (A)   |                                                 
 |                                                                                |                                                 
 |--------------------------------------------------------------------------------|                                                 
 |           |                                                                    |                                                 
 |VEHICLE    |   100.0 100.0 100.0  93.3  93.3  93.3  93.3  86.7  80.0  73.3      |                                                 
 |CONTROL    |                                                                    |                                                 
 |           |                                                                    |                                                 
 |3125 PPM   |   100.0 100.0  93.3  93.3  93.3  93.3  86.7  73.3  73.3  66.7      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |6250 PPM   |   100.0 100.0  86.7  86.7  80.0  73.3  73.3  60.0  60.0  60.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |12500   PPM|   100.0 100.0 100.0  93.3  86.7  73.3  66.7  66.7  66.7  60.0      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |25000   PPM|    93.3  93.3  93.3  93.3  93.3  93.3  93.3  93.3  93.3  73.3      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 |50000   PPM|   100.0 100.0  93.3  80.0  80.0  73.3  66.7  60.0  60.0  53.3      |                                                 
 |           |                                                                    |                                                 
 |           |                                                                    |                                                 
 ==================================================================================                                                 
                                                                                                                                   
                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                                      
                       STATISTICAL ANALYSIS OF SURVIVAL DATA                                                                        
                                    FEMALE MICE                                                                                     
                       FIRST TERMINAL SACRIFICE AT 275 DAYS                                                                         
 ===============================================================================================================================    
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |    
 |                                                                                                                             |    
 |                                                                                                                             |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |                                                                          DOSE                                               |    
 |                                                                                                                             |    
 |                                VEHICLE         3125 PPM        6250 PPM        12500   PPM     25000   PPM     50000   PPM  |    
 |                                CONTROL                                                                                      |    
 |-----------------------------------------------------------------------------------------------------------------------------|    
 |SURVIVAL AT END OF STUDY|       73.3%           66.7%           60.0%           60.0%           73.3%           53.3%        |    
 |(KAPLAN-MEIER)          |                                                                                                    |    
 |                        |                                                                                                    |    
 |SIGNIFICANCE (B)        |       P=0.454         P=0.916         P=0.541         P=0.596         P=1.000N        P=0.329      |    
 |(LIFE TABLE)            |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN DAY OF             |       205.3           189.6           132.7           169.3           207.3           154.6        |    
 |NATURAL DEATHS (C)      |       (35.2)          (30.6)          (25.9)          (23.9)          (61.4)          (27.2)       |    
 |(STANDARD ERROR)        |                                                                                                    |    
 |                        |                                                                                                    |    
 |MEAN LIFE SPAN (D)      |       256.4           246.5           218.1           232.7           256.9           218.8        |    
 |(STANDARD ERROR)        |       (11.8)          (14.3)          (21.1)          (16.5)          (16.7)          (20.2)       |    
 |                        |                                                                                                    |    
 ===============================================================================================================================    
                                                                                                                                    
       (A)  FIRST TERMINAL SACRIFICE                                                                                                
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.                                                                
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS                                                                    
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".                                                                      
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE                                                               
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)                                                           
                                                                                                                                   
                                             TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                             
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        VEHICLE CONTROL  = 1                                                        
                                                        3125 PPM         = 2                                                        
                                                        6250 PPM         = 3                                                        
                                                        12500   PPM      = 4                                                        
                                                        25000   PPM      = 5                                                        
                                                        50000   PPM      = 6                                                        
                                                                                                                                    
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
         |                                                                                                                          
         |                                                                                                                          
  100.00 +1                                1  3     5                    6                       2                                  
         |                                                                                                                          
         |                                                                                                                          
         |                                                                                                                          
   93.33 +                                 1  3     5              3  5  6              6  1     2  4                          2    
         |                                                                                                                          
P        |                                                                                                                          
E        |                                                                                                                          
R  86.67 +                                                         3  3                    1     1  4              5           4    
C        |                                                                                                                          
E        |                                                                                                                          
N        |                                                                                                                          
T  80.00 +                                                            3     3           6        1                 5        5  1  2 
         |                                                                                                                          
S        |                                                                                                                          
U        |                                                                                                                          
R  73.33 +                                                                  3                    3                          5  6  5 
V        |                                                                                                                          
I        |                                                                                                                          
V        |                                                                                                                          
A  66.67 +                                                                                       3  3                          6  6 
L        |                                                                                                                          
         |                                                                                                                          
         |                                                                                                                          
   60.00 +                                                                                          3                          1  1 
         |                                                                                                                          
         |                                                                                                                          
         |                                                                                                                          
   53.33 +                                                                                                                     3  3 
         |                                                                                                                          
         -+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+-
          0  1  2  3  4  5  6  7  8  9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 
                                                                                                                                    
                                                                     WEEK                                                           
                                                                                                                                    
NOTE: 14 obs hidden.                                                                                                                
                                                                                                                                   
                                             TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                             
                                                    KAPLAN-MEIER SURVIVAL CURVES                                                    
                                                        VEHICLE CONTROL  = 1                                                        
                                                        3125 PPM         = 2                                                        
                                                        6250 PPM         = 3                                                        
                                                        12500   PPM      = 4                                                        
                                                        25000   PPM      = 5                                                        
                                                        50000   PPM      = 6                                                        
                                                                                                                                    
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
                                                                                                                                    
                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.                                           
                                                                                                                                    
         |                                                                                                                          
         |                                                                                                                          
  100.00 +1           5              3        2     4     1                                                                         
         |                                                                                                                          
         |                                                                                                                          
         |                                                                                                                          
   93.33 +            5              3  3     2     4     1           4                       2  1                             5    
         |                                                                                                                          
P        |                                                                                                                          
E        |                                                                                                                          
R  86.67 +                              3                    3        4           4           2  1                 1                
C        |                                                                                                                          
E        |                                                                                                                          
N        |                                                                                                                          
T  80.00 +                                          6        3              3                    2  2              1           1    
         |                                                                                                                          
S        |                                                                                                                          
U        |                                                                                                                          
R  73.33 +                                                                  3     4        4     3  2                          1  1 
V        |                                                                                                                          
I        |                                                                                                                          
V        |                                                                                                                          
A  66.67 +                                                                                 4     3  3  6                       2  2 
L        |                                                                                                                          
         |                                                                                                                          
         |                                                                                                                          
   60.00 +                                                                                          3  6                       4  3 
         |                                                                                                                          
         |                                                                                                                          
         |                                                                                                                          
   53.33 +                                                                                                                     6  6 
         |                                                                                                                          
         -+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+-
          0  1  2  3  4  5  6  7  8  9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 
                                                                                                                                    
                                                                     WEEK                                                           
                                                                                                                                    
NOTE: 19 obs hidden.                                                                                                                
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.