National Toxicology Program

National Toxicology Program
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TDMS Study 99033-02 Pathology Tables

NTP  EXP/TEST: 99033-02                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                             PAGE: 1
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/05/03
ROUTE: DOSED FEED                                                                                                 TIME: 13:38:05

                                                         EIS REPORT 03
                                                       FINAL #3/P53 MICE


       FACILITY:  BIORELIANCE

       NTP C#:  C99033

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  22839-47-0

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 99033-02                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                             PAGE: 2
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/05/03
ROUTE: DOSED FEED                                           EISRPT03                                              TIME: 13:38:05
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 SPECIES-STRAIN: P53(C57BL/6)-MICE          SEX: FEMALE      WEEK ON DOSE: 40     FIRST DOSE: 10/14/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 VEHICLE CONTROL    15     16.9    1.2        14     26.1    2.4                     14      9.1    2.1

 3125 PPM           15     16.4    1.6        14     24.3    1.9        93.1         14      7.9    1.5

 6250 PPM           15     16.8    1.6        14     26.2    3.0       100.3         14      9.4    2.3

 12500   PPM        15     16.3    1.1        15     25.4    3.0        97.3         15      9.1    2.6

 25000   PPM        15     16.4    1.0        15     25.3    1.7        96.9         15      8.9    1.6

 50000   PPM        15     16.1    1.2        15     25.1    2.5        96.1         15      9.0    2.9




----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: P53(C57BL/6)-MICE          SEX: MALE        WEEK ON DOSE: 40     FIRST DOSE: 10/14/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 VEHICLE CONTROL    15     20.9    1.7        14     31.3    4.3                     14     10.4    3.7

 3125 PPM           15     20.3    1.6        15     30.3    3.1        96.8         15     10.0    2.8

 6250 PPM           15     20.1    1.5        13     29.7    2.5        94.8         13      9.7    1.9

 12500   PPM        15     20.1    1.7        15     29.8    3.5        95.2         15      9.7    3.1

 25000   PPM        15     20.2    1.9        14     30.1    3.0        96.1         14     10.0    3.7

 50000   PPM        15     20.2    1.4        14     29.9    3.2        95.5         14      9.7    2.4

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