TDMS Study 99033-02 Pathology Tables
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:08
FINAL/MICE
Facility: BIORELIANCE
Chemical CAS #: 22839-47-0
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:08
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Natural Death 1
Survivors
Terminal Sacrifice 14 14 14 15 15 15
Animals Examined Microscopically 15 15 15 15 15 15
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ALIMENTARY SYSTEM
Gallbladder (14) (15)
Lymphoma Malignant 1 (7%)
Intestine Large, Cecum (15) (1) (15)
Lymphoid Tissue, Lymphoma Malignant 1 (100%)
Liver (15) (15) (15) (15) (15) (15)
Lymphoma Malignant 1 (7%)
Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Pituitary Gland (9) (14) (13) (14) (11) (14)
Pars Distalis, Adenoma 1 (11%)
Thyroid Gland (14) (13) (14) (14) (13) (15)
Follicular Cell, Adenoma 1 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:08
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Pancreatic, Lymphoma Malignant 1 (100%)
Renal, Lymphoma Malignant 1 (100%)
Lymph Node, Mandibular (15) (13) (13) (15) (15) (14)
Lymphoma Malignant 1 (7%)
Lymph Node, Mesenteric (15) (14) (14) (14) (15) (15)
Sarcoma 1 (7%)
Lymph Node, Mediastinal (12) (13) (13) (12) (13) (15)
Lymphoma Malignant 1 (8%)
Spleen (15) (15) (15) (15) (15) (15)
Lymphoma Malignant 1 (7%) 1 (7%)
Thymus (14) (14) (14) (15) (15) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (13) (14) (14) (15) (12) (15)
Carcinoma 1 (8%) 1 (7%)
Skin (15) (1) (15)
Subcutaneous Tissue, Fibrosarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (15) (1) (15)
Femur, Osteosarcoma 1 (7%) 1 (7%)
Vertebra, Osteosarcoma 1 (100%)
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NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:08
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (14) (15) (15) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (14) (15) (15) (15) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Lymphoma Malignant 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:08
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 4 2 2 1 1
Total Primary Neoplasms 4 2 3 2 1
Total Animals with Benign Neoplasms 1 1
Total Benign Neoplasms 1 1
Total Animals with Malignant Neoplasms 3 2 2 1 1
Total Malignant Neoplasms 3 2 3 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:08
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 1 1
Moribund Sacrifice 1 1
Survivors
Terminal Sacrifice 14 15 13 15 14 14
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (14) (15)
Polyp Adenomatous 1 (7%)
Liver (14) (15) (15) (15) (14) (15)
Lymphoma Malignant 2 (13%)
Salivary Glands (14) (1) (1) (1) (15)
Lymphoma Malignant 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Prostate (14) (15) (15) (15) (14) (15)
Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:08
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (14) (15) (14) (15) (14) (15)
Lymphoma Malignant 1 (7%)
Lymph Node, Mesenteric (14) (14) (15) (13) (14) (15)
Lymphoma Malignant 1 (7%)
Lymph Node, Mediastinal (13) (14) (14) (13) (12) (13)
Lymphoma Malignant 2 (14%)
Spleen (14) (15) (15) (15) (14) (15)
Lymphoma Malignant 2 (13%)
Thymus (14) (15) (15) (14) (15) (14)
Lymphoma Malignant 2 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15)
Subcutaneous Tissue, Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (14) (15)
Lymphoma Malignant 2 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:08
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (14) (15) (15) (15) (14) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Lymphoma Malignant 2 (13%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 99033-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:08
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 2 1 2
Total Primary Neoplasms 2 1 2
Total Animals with Benign Neoplasms 1
Total Benign Neoplasms 1
Total Animals with Malignant Neoplasms 2 1 1
Total Malignant Neoplasms 2 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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