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TDMS Study 99033-03 Pathology Tables

NTP  EXP/TEST: 99033-03                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                             PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/05/03
ROUTE: DOSED FEED                                                                                                 TIME: 13:38:57

                                                         EIS REPORT 03
                                                      FINAL #3 TG:P16 MICE


       FACILITY:  BIORELIANCE

       NTP C#:  99033B

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  22839-47-0

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 99033-03                    TRANSGENIC MODEL EVALUATION II (ASPARTAME)                             PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/05/03
ROUTE: DOSED FEED                                           EISRPT03                                              TIME: 13:38:57
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: TG:P16-INK4A-MICE          SEX: FEMALE      WEEK ON DOSE: 40     FIRST DOSE: 10/27/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 VEHICLE CONTROL    15     17.9    1.6        13     27.4    3.3                     13      9.5    2.5

 3125 PPM           15     18.4    1.5        15     27.9    3.0       101.8         15      9.6    2.4

 6250 PPM           15     18.3    1.5        13     28.8    3.5       105.1         13     10.7    3.3

 12500   PPM        15     18.2    1.1        15     28.6    4.4       104.3         15     10.4    3.9

 25000   PPM        15     17.9    1.5        15     26.9    2.9        98.1         15      9.1    2.2

 50000   PPM        15     18.2    1.4        14     28.3    3.3       103.2         14     10.3    3.0




----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: TG:P16-INK4A-MICE          SEX: MALE        WEEK ON DOSE: 40     FIRST DOSE: 10/27/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 VEHICLE CONTROL    15     22.2    1.7        14     35.7    3.9                     14     13.2    3.0

 3125 PPM           15     22.1    1.4        14     33.1    2.6        92.7         14     11.2    2.5

 6250 PPM           15     22.2    1.3        15     33.7    3.5        94.3         15     11.5    2.8

 12500   PPM        15     22.0    1.3        14     35.0    4.4        98.0         14     13.0    3.3

 25000   PPM        15     21.8    1.6        14     35.6    3.4        99.7         14     13.6    2.5

 50000   PPM        15     21.9    1.7        15     34.2    4.3        95.7         15     12.3    3.5

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------