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TDMS Study 99033-03 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: BIORELIANCE                           TRANSGENIC MODEL EVALUATION II (ASPARTAME)                               DATE: 03/05/03  
EXPERIMENT: 99033 TEST: 03                                                                                        TIME: 13:38:24    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: SUBCHRON 26-WEEK                         ROUTE: DOSED FEED                                             NTP:  C99033B     
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                                                        FINAL #3 TG:P16 MICE                                                        
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BIORELIANCE                                      TRANSGENIC MODEL EVALUATION II (ASPARTAME)                  DATE: 03/05/03    
EXPERIMENT: 99033 TEST: 03                                                                                        TIME: 13:47:26    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: SUBCHRONIC (26-WEEK)                     ROUTE: DOSED FEED                                             NTP:  99033B      
CONT: N01-ES-65406                                                                                                CAS: 22839-47-0   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                          SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                       
==================================================================================================================================  
      VEHICLE CONTROL                 3125 PPM                           6250 PPM                         12500   PPM               
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.4    22.4       4.3     22.2    0.98      598      4.7     22.4    1.07     1301      4.2     22.1    0.95     2367       
  3     4.6    23.1       4.5     23.2    0.98      608      4.4     23.0    0.96     1200      4.6     22.9    1.00     2520       
  4     4.6    23.6       4.4     23.8    0.96      578      4.4     23.4    0.96     1181      4.4     23.8    0.96     2284       
  5     4.8    25.0       4.8     24.9    1.00      597      4.6     24.6    0.96     1164      4.7     24.8    0.98     2391       
  6     5.1    25.6       4.6     25.5    0.90      558      4.6     25.1    0.90     1145      4.5     25.2    0.88     2231       
  7     4.8    26.1       4.9     26.5    1.02      581      4.6     26.2    0.96     1086      4.7     25.6    0.98     2276       
  8     4.7    26.7       4.7     26.7    1.00      550      4.6     26.3    0.98     1095      4.8     26.7    1.02     2229       
  9     4.9    27.4       4.9     27.7    1.00      553      4.4     26.5    0.90     1042      4.2     27.2    0.86     1945       
 10     5.1    28.6       4.5     27.9    0.88      505      4.9     27.1    0.96     1135      4.7     27.6    0.92     2108       
 11     4.8    28.9       4.7     27.9    0.98      526      4.8     27.9    1.00     1085      4.7     28.2    0.98     2091       
 12     4.9    29.4       4.9     28.4    1.00      542      4.9     28.2    1.00     1086      4.6     28.3    0.94     2039       
 13     4.9    30.0       4.6     28.8    0.94      499      4.6     28.3    0.94     1013      4.7     29.0    0.96     2042       
 14     4.9    30.1       4.8     29.1    0.98      517      4.8     28.7    0.98     1047      5.1     29.6    1.04     2147       
 15     5.0    30.8       5.1     29.4    1.02      543      5.3     29.8    1.06     1120      5.0     29.9    1.00     2079       
 16     5.1    30.6       4.9     29.8    0.96      516      4.6     29.8    0.90      966      5.3     30.7    1.04     2159       
 17     4.8    31.6       4.4     30.7    0.92      448      4.7     30.8    0.98      960      4.8     31.7    1.00     1907       
 18     4.9    32.4       4.6     31.1    0.94      463      4.1     30.5    0.84      847      5.2     32.1    1.06     2028       
 19     4.5    32.8       4.4     31.5    0.98      440      4.4     30.1    0.98      904      4.5     32.4    1.00     1732       
 20     4.5    33.3       4.8     32.1    1.07      463      4.8     30.9    1.07      971      4.5     32.8    1.00     1697       
 21     4.8    34.0       4.9     32.6    1.02      472      4.8     31.9    1.00      941      5.0     33.1    1.04     1874       
 22     4.8    34.2       4.6     32.7    0.96      441      4.6     32.2    0.96      898      4.5     32.7    0.94     1733       
 23     4.8    34.4       4.7     32.7    0.98      451      4.4     32.2    0.92      864      4.5     33.0    0.94     1695       
 24     4.3    34.5       4.3     32.7    1.00      407      4.3     32.2    1.00      840      4.5     33.3    1.05     1672       
 25     4.8    34.6       4.6     32.8    0.96      440      4.5     32.2    0.94      881      4.4     33.2    0.92     1649       
 26     4.5    34.6       4.4     32.7    0.98      425      4.5     32.2    1.00      866      4.7     33.6    1.04     1754       
 27     4.6    34.6       4.6     32.7    1.00      443      4.5     32.6    0.98      873      4.6     33.8    1.00     1701       
 28     4.7    35.1       4.7     33.4    1.00      439      4.5     32.9    0.96      847      4.7     34.3    1.00     1695       
 29     4.8    35.6       4.7     33.9    0.98      438      4.3     33.3    0.90      815      4.6     34.6    0.96     1659       
 30     4.6    35.9       4.4     33.8    0.96      407      4.6     33.8    1.00      850      4.4     35.0    0.96     1570       
 31     4.5    35.8       4.4     33.4    0.98      414      4.4     33.9    0.98      812      4.6     34.8    1.02     1639       
 32     5.0    36.1       4.7     33.5    0.94      438      4.3     33.7    0.86      800      4.6     34.8    0.92     1644       
 33     4.9    35.6       5.0     33.5    1.02      462      4.8     34.0    0.98      878      4.7     34.3    0.96     1714       
 34     4.7    36.1       4.4     33.1    0.94      419      4.3     34.2    0.91      791      4.3     34.9    0.91     1547       
 35     5.4    35.4       5.1     33.0    0.94      485      4.9     33.9    0.91      897      5.4     35.3    1.00     1895       
 36     4.9    35.6       4.7     33.6    0.96      440      4.8     34.3    0.98      865      4.8     35.5    0.98     1687       
 37     4.7    35.6       4.7     33.1    1.00      446      4.7     34.1    1.00      856      5.0     35.1    1.06     1781       
 38     4.9    35.9       4.6     32.6    0.94      445      5.0     34.0    1.02      926      4.9     35.2    1.00     1742       
 39     4.7    35.6       4.5     32.4    0.96      436      4.4     33.9    0.94      818      4.6     34.9    0.98     1641       
 40     5.0    35.7       5.2     33.1    1.04      495      4.9     33.7    0.98      916      4.8     35.0    0.96     1716       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.8    26.4       4.6     26.1    0.97      558      4.6     25.7    0.96     1128      4.6     25.9    0.95     2210       
SD(D)   0.2               0.2             0.04       36      0.2             0.05       78      0.2             0.05      170       
CV(E)   4.4               4.6             4.4       6.4      3.9             4.7       6.9      4.4             4.9       7.7       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.8    34.3       4.7     32.4    0.98      453      4.6     32.4    0.96      891      4.7     33.5    0.99     1769       
SD(D)   0.2               0.2             0.04       33      0.3             0.05       75      0.3             0.04      166       
CV(E)   4.9               5.2             3.6       7.4      5.8             5.6       8.4      6.1             4.5       9.4       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                    
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                 
=============================================================================                                                       
                  25000   PPM                        50000   PPM                                                                    
       ---------------------------------  ---------------------------------                                                         
                         DOSE/                              DOSE/                                                                   
       GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL                                                                  
       FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/                                                         
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                         
=============================================================================                                                       
  2     4.0     22.0     0.91    4525      3.9     22.3     0.89    8802                                                            
  3     4.1     22.7     0.89    4555      4.1     23.0     0.89    8809                                                            
  4     4.2     23.0     0.91    4575      4.2     23.6     0.91    8881                                                            
  5     4.7     24.7     0.98    4788      4.4     24.9     0.92    8835                                                            
  6     4.2     25.0     0.82    4202      4.5     25.1     0.88    9012                                                            
  7     4.6     26.1     0.96    4419      4.5     26.4     0.94    8491                                                            
  8     4.7     26.6     1.00    4439      4.4     26.5     0.94    8308                                                            
  9     4.2     27.1     0.86    3845      4.1     26.9     0.84    7709                                                            
 10     4.1     27.7     0.80    3714      4.7     27.3     0.92    8670                                                            
 11     4.5     28.0     0.94    4021      4.8     28.1     1.00    8499                                                            
 12     4.2     28.2     0.86    3715      4.8     28.9     0.98    8385                                                            
 13     5.0     29.1     1.02    4255      4.8     29.2     0.98    8263                                                            
 14     4.6     29.1     0.94    3951      4.8     29.4     0.98    8192                                                            
 15     4.8     29.5     0.96    4066      4.8     29.9     0.96    8047                                                            
 16     4.8     29.8     0.94    3991      4.8     30.4     0.94    7849                                                            
 17     4.4     30.5     0.92    3641      4.5     31.4     0.94    7214                                                            
 18     4.5     31.6     0.92    3556      4.4     31.6     0.90    7012                                                            
 19     4.5     32.0     1.00    3482      4.6     32.1     1.02    7177                                                            
 20     4.7     32.2     1.04    3642      4.7     32.7     1.04    7242                                                            
 21     4.8     33.0     1.00    3673      4.5     32.8     0.94    6908                                                            
 22     4.5     33.1     0.94    3376      4.4     33.1     0.92    6639                                                            
 23     4.6     33.0     0.96    3447      4.3     33.0     0.90    6458                                                            
 24     4.4     33.0     1.02    3310      4.3     33.4     1.00    6495                                                            
 25     4.3     32.9     0.90    3281      4.3     33.3     0.90    6481                                                            
 26     4.4     33.1     0.98    3335      4.4     33.5     0.98    6551                                                            
 27     4.5     33.3     0.98    3397      4.5     33.7     0.98    6626                                                            
 28     4.6     33.9     0.98    3397      4.4     33.8     0.94    6559                                                            
 29     4.4     34.3     0.92    3201      4.3     33.9     0.90    6382                                                            
 30     4.6     34.6     1.00    3347      4.4     34.3     0.96    6474                                                            
 31     4.6     34.5     1.02    3332      4.4     34.4     0.98    6455                                                            
 32     4.4     34.6     0.88    3202      4.4     34.0     0.88    6442                                                            
 33     4.8     34.6     0.98    3488      4.6     33.9     0.94    6844                                                            
 34     4.4     35.1     0.94    3133      4.4     34.4     0.94    6462                                                            
 35     4.5     34.8     0.83    3258      4.8     34.3     0.89    7040                                                            
 36     4.7     35.3     0.96    3346      4.7     34.3     0.96    6871                                                            
 37     4.7     34.9     1.00    3364      4.6     33.9     0.98    6811                                                            
 38     4.7     35.0     0.96    3338      4.7     34.1     0.96    6883                                                            
 39     4.6     35.4     0.98    3261      4.6     34.4     0.98    6738                                                            
 40     4.8     35.6     0.96    3388      4.8     34.2     0.96    7042                                                            
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.4     25.8     0.91    4254      4.4     26.0     0.92    8555                                                            
SD(D)   0.3              0.07     359      0.3              0.05     360                                                            
CV(E)   7.2              7.6      8.4      7.1              5.1      4.2                                                            
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.6     33.3     0.96    3452      4.5     33.1     0.95    6885                                                            
SD(D)   0.2              0.05     239      0.2              0.04     489                                                            
CV(E)   3.4              4.9      6.9      3.9              4.3      7.1                                                            
=============================================================================                                                       
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                          SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                       
==================================================================================================================================  
      VEHICLE CONTROL                 3125 PPM                           6250 PPM                         12500   PPM               
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.8    18.7       5.4     19.0     1.13     887      4.5     18.4     0.94    1517      4.3     18.6     0.90    2920       
  3     4.8    19.8       4.9     20.3     1.02     758      4.9     19.8     1.02    1541      4.4     20.0     0.92    2756       
  4     4.9    20.7       4.8     21.0     0.98     712      4.5     20.6     0.92    1351      4.4     20.8     0.90    2659       
  5     5.1    21.2       5.3     21.6     1.04     769      5.3     21.9     1.04    1511      4.8     21.4     0.94    2796       
  6     5.1    22.1       4.9     22.3     0.96     684      4.8     22.4     0.94    1346      5.1     22.3     1.00    2884       
  7     5.0    22.5       5.5     23.0     1.10     753      4.7     22.6     0.94    1298      5.0     22.8     1.00    2716       
  8     5.5    21.8       5.7     22.3     1.04     801      5.4     22.6     0.98    1508      5.5     22.9     1.00    2981       
  9     5.7    22.7       5.0     23.1     0.88     672      4.5     23.0     0.79    1227      4.7     23.0     0.82    2559       
 10     5.9    23.1       5.0     23.4     0.85     666      5.4     22.8     0.92    1479      4.8     23.7     0.81    2551       
 11     5.9    23.0       5.4     23.6     0.92     716      4.8     23.7     0.81    1258      5.1     23.9     0.86    2673       
 12     5.6    23.3       5.2     24.1     0.93     675      4.8     24.0     0.86    1236      5.1     24.7     0.91    2581       
 13     4.8    23.5       4.5     24.5     0.94     573      4.4     23.8     0.92    1166      4.5     25.0     0.94    2237       
 14     5.3    23.3       5.9     24.2     1.11     762      5.5     24.0     1.04    1431      5.9     24.6     1.11    2989       
 15     6.3    24.3       5.9     25.0     0.94     743      6.2     25.1     0.98    1540      6.0     25.1     0.95    2985       
 16     5.7    24.3       5.8     24.9     1.02     729      5.5     25.1     0.96    1363      6.1     25.3     1.07    2994       
 17     5.2    24.4       4.7     25.7     0.90     571      4.7     26.1     0.90    1128      4.7     25.8     0.90    2269       
 18     5.1    24.8       4.7     25.8     0.92     569      4.4     26.1     0.86    1055      4.8     25.8     0.94    2349       
 19     4.2    25.1       4.5     26.3     1.07     540      4.2     26.1     1.00    1002      4.5     26.2     1.07    2132       
 20     4.6    25.3       4.8     26.7     1.04     565      5.0     25.5     1.09    1229      4.7     26.3     1.02    2208       
 21     5.2    25.7       5.4     27.2     1.04     619      5.1     26.1     0.98    1225      5.1     26.9     0.98    2376       
 22     4.8    25.4       4.9     27.0     1.02     570      4.6     26.7     0.96    1071      4.5     26.8     0.94    2089       
 23     5.1    25.3       4.8     26.8     0.94     556      4.8     26.7     0.94    1123      4.9     26.6     0.96    2286       
 24     4.7    25.7       4.5     27.2     0.96     516      4.5     26.9     0.96    1034      4.5     26.5     0.96    2097       
 25     4.6    25.9       4.6     27.4     1.00     527      4.6     26.4     1.00    1081      4.5     26.7     0.98    2125       
 26     4.9    26.2       4.6     27.3     0.94     528      4.6     26.7     0.94    1077      4.6     26.8     0.94    2138       
 27     4.7    25.6       4.6     26.9     0.98     531      4.7     26.5     1.00    1115      4.8     27.0     1.02    2208       
 28     4.4    26.2       4.5     27.9     1.02     501      4.6     27.4     1.05    1045      4.5     27.4     1.02    2042       
 29     4.6    26.8       4.6     28.1     1.00     509      4.3     27.0     0.93     986      4.5     27.6     0.98    2049       
 30     4.4    26.4       4.4     28.5     1.00     480      4.3     27.2     0.98     993      4.2     27.8     0.95    1905       
 31     4.4    25.6       4.4     28.2     1.00     486      4.6     28.3     1.05    1006      4.3     27.7     0.98    1950       
 32     4.5    26.2       4.5     28.1     1.00     497      4.5     27.8     1.00    1019      4.2     27.7     0.93    1897       
 33     5.8    26.8       5.1     28.0     0.88     568      4.8     28.1     0.83    1078      4.7     27.5     0.81    2135       
 34     4.9    27.1       4.3     28.4     0.88     479      4.4     28.3     0.90     973      4.4     27.7     0.90    1968       
 35     5.8    27.0       5.9     28.0     1.02     656      5.3     27.9     0.91    1177      5.5     28.0     0.95    2439       
 36     5.4    27.0       5.2     28.1     0.96     575      4.9     28.1     0.91    1093      5.1     28.0     0.94    2260       
 37     5.2    26.8       5.1     27.6     0.98     573      5.0     27.7     0.96    1122      5.1     27.8     0.98    2284       
 38     5.0    26.9       4.9     27.7     0.98     550      4.7     28.0     0.94    1061      4.8     27.8     0.96    2155       
 39     4.8    26.7       4.5     27.6     0.94     507      4.7     28.3     0.98    1036      4.6     28.2     0.96    2054       
 40     5.4    27.4       5.4     27.9     1.00     600      5.5     28.8     1.02    1195      5.2     28.6     0.96    2296       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.2    21.9       5.1     22.4     0.98     722      4.8     22.2     0.92    1370      4.8     22.4     0.92    2693       
SD(D)   0.4               0.4              0.09      80      0.4              0.07     135      0.4              0.06     201       
CV(E)   8.2               6.9              8.7     11.0      7.6              8.1      9.9      7.4              6.9      7.5       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    5.0    25.9       4.9     27.1     0.98     567      4.8     26.9     0.97    1121      4.8     27.0     0.97    2247       
SD(D)   0.5               0.5              0.06      77      0.5              0.06     138      0.5              0.06     301       
CV(E)  10.1              10.3              5.6     13.5      9.5              6.0     12.3     10.6              6.1     13.4       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
               FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                  
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                 
=============================================================================                                                       
                  25000   PPM                        50000   PPM                                                                    
       ---------------------------------  ---------------------------------                                                         
                         DOSE/                              DOSE/                                                                   
       GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL                                                                  
       FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/                                                         
WEEK   DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)                                                         
=============================================================================                                                       
  2     4.3     18.6     0.90    5761      4.1     18.8     0.85   10888                                                            
  3     4.3     19.6     0.90    5434      4.2     20.0     0.88   10466                                                            
  4     4.2     20.3     0.86    5204      4.4     20.7     0.90   10640                                                            
  5     4.6     20.9     0.90    5479      5.0     21.9     0.98   11426                                                            
  6     4.8     21.8     0.94    5514      5.0     22.5     0.98   11210                                                            
  7     5.4     22.3     1.08    6050      4.9     22.6     0.98   10898                                                            
  8     5.1     22.0     0.93    5794      5.3     22.5     0.96   11842                                                            
  9     4.3     22.1     0.75    4907      4.4     22.8     0.77    9617                                                            
 10     4.6     22.8     0.78    5069      5.1     23.1     0.86   11074                                                            
 11     5.1     22.9     0.86    5576      5.3     23.6     0.90   11196                                                            
 12     4.7     23.1     0.84    5039      5.0     23.9     0.89   10461                                                            
 13     4.8     23.8     1.00    5013      4.5     23.9     0.94    9453                                                            
 14     5.1     23.3     0.96    5508      5.6     24.2     1.06   11475                                                            
 15     5.9     23.8     0.94    6215      5.5     24.8     0.87   11035                                                            
 16     5.3     23.7     0.93    5616      5.1     24.5     0.89   10383                                                            
 17     4.5     24.2     0.87    4688      4.8     25.6     0.92    9320                                                            
 18     4.5     24.9     0.88    4503      4.5     25.7     0.88    8794                                                            
 19     4.1     25.1     0.98    4117      4.4     25.8     1.05    8460                                                            
 20     4.7     25.1     1.02    4675      5.1     26.0     1.11    9808                                                            
 21     5.0     25.6     0.96    4906      5.1     26.5     0.98    9620                                                            
 22     4.7     25.4     0.98    4665      4.8     26.5     1.00    9073                                                            
 23     4.7     25.7     0.92    4551      4.9     26.7     0.96    9144                                                            
 24     4.5     25.4     0.96    4403      4.6     26.6     0.98    8674                                                            
 25     4.5     25.3     0.98    4425      4.3     26.2     0.93    8297                                                            
 26     4.5     25.4     0.92    4436      4.5     26.2     0.92    8651                                                            
 27     4.8     25.6     1.02    4653      4.8     26.7     1.02    8955                                                            
 28     4.5     25.9     1.02    4374      4.6     26.9     1.05    8461                                                            
 29     4.3     26.1     0.93    4094      4.4     26.7     0.96    8267                                                            
 30     4.5     26.4     1.02    4259      4.4     27.1     1.00    8172                                                            
 31     4.3     26.3     0.98    4127      4.4     27.5     1.00    8000                                                            
 32     4.7     26.7     1.04    4365      4.5     27.4     1.00    8234                                                            
 33     4.6     26.5     0.79    4335      5.3     27.6     0.91    9700                                                            
 34     4.6     26.9     0.94    4233      4.3     28.1     0.88    7596                                                            
 35     4.9     26.9     0.84    4534      5.1     27.8     0.88    9251                                                            
 36     4.8     26.4     0.89    4519      5.1     28.0     0.94    9129                                                            
 37     5.0     26.8     0.96    4655      4.9     27.7     0.94    8789                                                            
 38     4.9     26.6     0.98    4613      5.1     27.7     1.02    9244                                                            
 39     4.7     27.1     0.98    4344      4.5     27.8     0.94    8069                                                            
 40     5.1     26.9     0.94    4697      5.1     28.3     0.94    9044                                                            
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.7     21.7     0.89    5403      4.8     22.2     0.91   10764                                                            
SD(D)   0.4              0.09     361      0.4              0.06     697                                                            
CV(E)   8.0              9.9      6.7      9.1              7.0      6.5                                                            
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.7     25.7     0.95    4611      4.8     26.7     0.96    9024                                                            
SD(D)   0.4              0.06     477      0.4              0.06     899                                                            
CV(E)   7.7              6.2     10.3      7.7              6.4     10.0                                                            
=============================================================================                                                       
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                         DIAGNOSTIC TRAILER REPORT                                                                                  
                         FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                          
                         SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                        
==================================================================================================================================  
      VEHICLE CONTROL              3125 PPM                 6250 PPM               12500   PPM              25000   PPM             
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               22.2  15                 22.1  15                 22.2  15                 22.0  15                 21.8  15      
  1               22.2  15                 22.1  15                 22.2  15                 22.0  15                 21.8  15      
  2   4.4  2565   22.4  15     4.3  2565   22.2  15     4.7  2565   22.4  15     4.2  2565   22.1  15     4.0  2565   22.0  15      
  3   4.6  2490   23.1  15     4.5  2489   23.2  15     4.4  2490   23.0  15     4.6  2475   22.9  15     4.1  2475   22.7  15      
  4   4.6  2520   23.6  15     4.4  2517   23.8  15     4.4  2520   23.4  15     4.4  2520   23.8  15     4.2  2353   23.0  14      
  5   4.8  2520   25.0  15     4.8  2520   24.9  15     4.6  2520   24.6  15     4.7  2535   24.8  15     4.7  2352   24.7  14      
  6   5.1  2505   25.6  15     4.6  2505   25.5  15     4.6  2490   25.1  15     4.5  2475   25.2  15     4.2  2338   25.0  14      
  7   4.8  2535   26.1  15     4.9  2535   26.5  15     4.6  2535   26.2  15     4.7  2550   25.6  15     4.6  2366   26.1  14      
  8   4.7  2513   26.7  15     4.7  2511   26.7  15     4.6  2535   26.3  15     4.8  2352   26.7  14     4.7  2352   26.6  14      
  9   4.9  2346   27.4  15     4.9  2499   27.7  15     4.4  2475   26.5  15     4.2  2310   27.2  14     4.2  2310   27.1  14      
 10   5.1  2352   28.6  14     4.5  2520   27.9  15     4.9  2520   27.1  15     4.7  2352   27.6  14     4.1  2360   27.7  14      
 11   4.8  2366   28.9  14     4.7  2548   27.9  15     4.8  2550   27.9  15     4.7  2394   28.2  14     4.5  2397   28.0  14      
 12   4.9  2338   29.4  14     4.9  2505   28.4  15     4.9  2505   28.2  15     4.6  2352   28.3  14     4.2  2352   28.2  14      
 13   4.9  2352   30.0  14     4.6  2520   28.8  15     4.6  2550   28.3  15     4.7  2324   29.0  14     5.0  2324   29.1  14      
 14   4.9  2422   30.1  14     4.8  2595   29.1  15     4.8  2572   28.7  15     5.1  2422   29.6  14     4.6  2408   29.1  14      
 15   5.0  2296   30.8  14     5.1  2460   29.4  15     5.3  2445   29.8  15     5.0  2310   29.9  14     4.8  2310   29.5  14      
 16   5.1  2394   30.6  14     4.9  2550   29.8  15     4.6  2595   29.8  15     5.3  2366   30.7  14     4.8  2380   29.8  14      
 17   4.8  2310   31.6  14     4.4  2475   30.7  15     4.7  2445   30.8  15     4.8  2338   31.7  14     4.4  2324   30.5  14      
 18   4.9  2352   32.4  14     4.6  2520   31.1  15     4.1  2520   30.5  15     5.2  2352   32.1  14     4.5  2338   31.6  14      
 19   4.5  2352   32.8  14     4.4  2520   31.5  15     4.4  2565   30.1  15     4.5  2338   32.4  14     4.5  2352   32.0  14      
 20   4.5  2352   33.3  14     4.8  2520   32.1  15     4.8  2520   30.9  15     4.5  2352   32.8  14     4.7  2352   32.2  14      
 21   4.8  2352   34.0  14     4.9  2520   32.6  15     4.8  2505   31.9  15     5.0  2352   33.1  14     4.8  2339   33.0  14      
 22   4.8  2352   34.2  14     4.6  2520   32.7  15     4.6  2505   32.2  15     4.5  2380   32.7  14     4.5  2380   33.1  14      
 23   4.8  2352   34.4  14     4.7  2520   32.7  15     4.4  2520   32.2  15     4.5  2338   33.0  14     4.6  2338   33.0  14      
 24   4.3  2352   34.5  14     4.3  2535   32.7  15     4.3  2520   32.2  15     4.5  2366   33.3  14     4.4  2366   33.0  14      
 25   4.8  2352   34.6  14     4.6  2505   32.8  15     4.5  2550   32.2  15     4.4  2338   33.2  14     4.3  2338   32.9  14      
 26   4.5  2366   34.6  14     4.4  2535   32.7  15     4.5  2535   32.2  15     4.7  2366   33.6  14     4.4  2366   33.1  14      
 27   4.6  2380   34.6  14     4.6  2535   32.7  15     4.5  2520   32.6  15     4.6  2324   33.8  14     4.5  2324   33.3  14      
 28   4.7  2366   35.1  14     4.7  2535   33.4  15     4.5  2505   32.9  15     4.7  2352   34.3  14     4.6  2352   33.9  14      
 29   4.8  2296   35.6  14     4.7  2475   33.9  15     4.3  2535   33.3  15     4.6  2366   34.6  14     4.4  2366   34.3  14      
 30   4.6  2352   35.9  14     4.4  2517   33.8  15     4.6  2520   33.8  15     4.4  2341   35.0  14     4.6  2338   34.6  14      
 31   4.5  2352   35.8  14     4.4  2523   33.4  15     4.4  2490   33.9  15     4.6  2380   34.8  14     4.6  2366   34.5  14      
 32   5.0  2352   36.1  14     4.7  2520   33.5  15     4.3  2580   33.7  15     4.6  2338   34.8  14     4.4  2352   34.6  14      
 33   4.9  2352   35.6  14     5.0  2520   33.5  15     4.8  2475   34.0  15     4.7  2380   34.3  14     4.8  2380   34.6  14      
 34   4.7  2338   36.1  14     4.4  2505   33.1  15     4.3  2505   34.2  15     4.3  2338   34.9  14     4.4  2346   35.1  14      
 35   5.4  2352   35.4  14     5.1  2352   33.0  14     4.9  2565   33.9  15     5.4  2338   35.3  14     4.5  2338   34.8  14      
 36   4.9  2352   35.6  14     4.7  2352   33.6  14     4.8  2475   34.3  15     4.8  2366   35.5  14     4.7  2366   35.3  14      
 37   4.7  2352   35.6  14     4.7  2352   33.1  14     4.7  2520   34.1  15     5.0  2338   35.1  14     4.7  2338   34.9  14      
 38   4.9  2338   35.9  14     4.6  2352   32.6  14     5.0  2520   34.0  15     4.9  2366   35.2  14     4.7  2366   35.0  14      
 39   4.7  2352   35.6  14     4.5  2352   32.4  14     4.4  2520   33.9  15     4.6  2351   34.9  14     4.6  2352   35.4  14      
 40   5.0  2353   35.7  14     5.2  2353   33.1  14     4.9  2514   33.7  15     4.8  2316   35.0  14     4.8  2303   35.6  14      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           26.1                     25.8                     25.5                     25.6                     25.5          
14 TO 52          34.3                     32.4                     32.4                     33.5                     33.3          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
DIAGNOSTIC TRAILER REPORT                                                                                                           
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                                   
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                 
==============================                                                                                                      
        50000   PPM                                                                                                                 
     ----------------------                                                                                                         
     DAILY FEED  BODY  NUM                                                                                                          
WEEK FEED HOURS   WGT  WGTS                                                                                                         
===============================                                                                                                     
  B               21.9  15                                                                                                          
  1               21.9  15                                                                                                          
  2   3.9  2565   22.3  15                                                                                                          
  3   4.1  2490   23.0  15                                                                                                          
  4   4.2  2520   23.6  15                                                                                                          
  5   4.4  2490   24.9  15                                                                                                          
  6   4.5  2520   25.1  15                                                                                                          
  7   4.5  2520   26.4  15                                                                                                          
  8   4.4  2535   26.5  15                                                                                                          
  9   4.1  2475   26.9  15                                                                                                          
 10   4.7  2535   27.3  15                                                                                                          
 11   4.8  2550   28.1  15                                                                                                          
 12   4.8  2520   28.9  15                                                                                                          
 13   4.8  2520   29.2  15                                                                                                          
 14   4.8  2580   29.4  15                                                                                                          
 15   4.8  2460   29.9  15                                                                                                          
 16   4.8  2580   30.4  15                                                                                                          
 17   4.5  2460   31.4  15                                                                                                          
 18   4.4  2520   31.6  15                                                                                                          
 19   4.6  2535   32.1  15                                                                                                          
 20   4.7  2520   32.7  15                                                                                                          
 21   4.5  2505   32.8  15                                                                                                          
 22   4.4  2520   33.1  15                                                                                                          
 23   4.3  2505   33.0  15                                                                                                          
 24   4.3  2520   33.4  15                                                                                                          
 25   4.3  2520   33.3  15                                                                                                          
 26   4.4  2535   33.5  15                                                                                                          
 27   4.5  2490   33.7  15                                                                                                          
 28   4.4  2520   33.8  15                                                                                                          
 29   4.3  2550   33.9  15                                                                                                          
 30   4.4  2505   34.3  15                                                                                                          
 31   4.4  2505   34.4  15                                                                                                          
 32   4.4  2565   34.0  15                                                                                                          
 33   4.6  2505   33.9  15                                                                                                          
 34   4.4  2505   34.4  15                                                                                                          
 35   4.8  2550   34.3  15                                                                                                          
 36   4.7  2505   34.3  15                                                                                                          
 37   4.6  2535   33.9  15                                                                                                          
 38   4.7  2505   34.1  15                                                                                                          
 39   4.6  2520   34.4  15                                                                                                          
 40   4.8  2504   34.2  15                                                                                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           25.7                                                                                                              
14 TO 52          33.1                                                                                                              
==============================                                                                                                      
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                         DIAGNOSTIC TRAILER REPORT                                                                                  
                         FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                        
                         SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                        
==================================================================================================================================  
      VEHICLE CONTROL              3125 PPM                 6250 PPM               12500   PPM              25000   PPM             
     ----------------------   ----------------------   ----------------------   ----------------------   ----------------------     
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM      
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS     
=================================================================================================================================== 
  B               17.9  15                 18.4  15                 18.3  15                 18.2  15                 17.9  15      
  1               17.9  15                 18.4  15                 18.3  15                 18.2  15                 17.9  15      
  2   4.8  2565   18.7  15     5.4  2565   19.0  15     4.5  2565   18.4  15     4.3  2565   18.6  15     4.3  2565   18.6  15      
  3   4.8  2327   19.8  14     4.9  2490   20.3  15     4.9  2490   19.8  15     4.4  2475   20.0  15     4.3  2489   19.6  15      
  4   4.9  2349   20.7  14     4.8  2520   21.0  15     4.5  2520   20.6  15     4.4  2520   20.8  15     4.2  2521   20.3  15      
  5   5.1  2352   21.2  14     5.3  2520   21.6  15     5.3  2519   21.9  15     4.8  2535   21.4  15     4.6  2520   20.9  15      
  6   5.1  2338   22.1  14     4.9  2495   22.3  15     4.8  2490   22.4  15     5.1  2475   22.3  15     4.8  2505   21.8  15      
  7   5.0  2366   22.5  14     5.5  2535   23.0  15     4.7  2535   22.6  15     5.0  2550   22.8  15     5.4  2535   22.3  15      
  8   5.5  2380   21.8  14     5.7  2533   22.3  15     5.4  2535   22.6  15     5.5  2520   22.9  15     5.1  2514   22.0  15      
  9   5.7  2310   22.7  14     5.0  2475   23.1  15     4.5  2475   23.0  15     4.7  2475   23.0  15     4.3  2475   22.1  15      
 10   5.9  2352   23.1  14     5.0  2520   23.4  15     5.4  2520   22.8  15     4.8  2520   23.7  15     4.6  2535   22.8  15      
 11   5.9  2366   23.0  14     5.4  2550   23.6  15     4.8  2550   23.7  15     5.1  2565   23.9  15     5.1  2580   22.9  15      
 12   5.6  2338   23.3  14     5.2  2505   24.1  15     4.8  2505   24.0  15     5.1  2520   24.7  15     4.7  2520   23.1  15      
 13   4.8  2352   23.5  14     4.5  2520   24.5  15     4.4  2550   23.8  15     4.5  2490   25.0  15     4.8  2499   23.8  15      
 14   5.3  2422   23.3  14     5.9  2595   24.2  15     5.5  2565   24.0  15     5.9  2595   24.6  15     5.1  2580   23.3  15      
 15   6.3  2296   24.3  14     5.9  2296   25.0  15     6.2  2441   25.1  15     6.0  2310   25.1  15     5.9  2475   23.8  15      
 16   5.7  2210   24.3  14     5.8  2550   24.9  15     5.5  2422   25.1  15     6.1  2549   25.3  15     5.3  2550   23.7  15      
 17   5.2  2310   24.4  14     4.7  2475   25.7  15     4.7  2282   26.1  14     4.7  2491   25.8  15     4.5  2490   24.2  15      
 18   5.1  2352   24.8  14     4.7  2520   25.8  15     4.4  2352   26.1  14     4.8  2520   25.8  15     4.5  2505   24.9  15      
 19   4.2  2352   25.1  14     4.5  2520   26.3  15     4.2  2394   26.1  14     4.5  2505   26.2  15     4.1  2520   25.1  15      
 20   4.6  2352   25.3  14     4.8  2520   26.7  15     5.0  2352   25.5  14     4.7  2520   26.3  15     4.7  2520   25.1  15      
 21   5.2  2352   25.7  14     5.4  2520   27.2  15     5.1  2338   26.1  14     5.1  2520   26.9  15     5.0  2505   25.6  15      
 22   4.8  2352   25.4  14     4.9  2520   27.0  15     4.6  2338   26.7  14     4.5  2550   26.8  15     4.7  2550   25.4  15      
 23   5.1  2352   25.3  14     4.8  2520   26.8  15     4.8  2352   26.7  14     4.9  2505   26.6  15     4.7  2505   25.7  15      
 24   4.7  2352   25.7  14     4.5  2535   27.2  15     4.5  2352   26.9  14     4.5  2535   26.5  15     4.5  2535   25.4  15      
 25   4.6  2352   25.9  14     4.6  2505   27.4  15     4.6  2380   26.4  14     4.5  2505   26.7  15     4.5  2505   25.3  15      
 26   4.9  2366   26.2  14     4.6  2535   27.3  15     4.6  2358   26.7  14     4.6  2535   26.8  15     4.5  2535   25.4  15      
 27   4.7  2380   25.6  14     4.6  2535   26.9  15     4.7  2352   26.5  14     4.8  2490   27.0  15     4.8  2490   25.6  15      
 28   4.4  2366   26.2  14     4.5  2535   27.9  15     4.6  2338   27.4  14     4.5  2520   27.4  15     4.5  2520   25.9  15      
 29   4.6  2296   26.8  14     4.6  2475   28.1  15     4.3  2366   27.0  14     4.5  2535   27.6  15     4.3  2535   26.1  15      
 30   4.4  2350   26.4  14     4.4  2510   28.5  15     4.3  2352   27.2  14     4.2  2505   27.8  15     4.5  2505   26.4  15      
 31   4.4  2352   25.6  14     4.4  2535   28.2  15     4.6  2324   28.3  14     4.3  2550   27.7  15     4.3  2535   26.3  15      
 32   4.5  2352   26.2  14     4.5  2520   28.1  15     4.5  2236   27.8  13     4.2  2505   27.7  15     4.7  2520   26.7  15      
 33   5.8  2184   26.8  13     5.1  2520   28.0  15     4.8  1982   28.1  13     4.7  2550   27.5  15     4.6  2380   26.5  15      
 34   4.9  2171   27.1  13     4.3  2505   28.4  15     4.4  2171   28.3  13     4.4  2505   27.7  15     4.6  2520   26.9  15      
 35   5.8  2186   27.0  13     5.9  2524   28.0  15     5.3  2223   27.9  13     5.5  2500   28.0  15     4.9  2505   26.9  15      
 36   5.4  2184   27.0  13     5.2  2515   28.1  15     4.9  2145   28.1  13     5.1  2543   28.0  15     4.8  2535   26.4  15      
 37   5.2  2184   26.8  13     5.1  2520   27.6  15     5.0  2184   27.7  13     5.1  2505   27.8  15     5.0  2505   26.8  15      
 38   5.0  2172   26.9  13     4.9  2520   27.7  15     4.7  2184   28.0  13     4.8  2535   27.8  15     4.9  2535   26.6  15      
 39   4.8  2184   26.7  13     4.5  2520   27.6  15     4.7  2184   28.3  13     4.6  2520   28.2  15     4.7  2520   27.1  15      
 40   5.4  2197   27.4  13     5.4  2535   27.9  15     5.5  2184   28.8  13     5.2  2505   28.6  15     5.1  2505   26.9  15      
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           21.6                     22.0                     21.9                     22.1                     21.4          
14 TO 52          25.9                     27.1                     26.9                     27.0                     25.7          
==================================================================================================================================  
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
DIAGNOSTIC TRAILER REPORT                                                                                                           
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                                 
SUBCHRONIC (26-WEEK) DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)                                                 
==============================                                                                                                      
        50000   PPM                                                                                                                 
     ----------------------                                                                                                         
     DAILY FEED  BODY  NUM                                                                                                          
WEEK FEED HOURS   WGT  WGTS                                                                                                         
===============================                                                                                                     
  B               18.2  15                                                                                                          
  1               18.2  15                                                                                                          
  2   4.1  2565   18.8  15                                                                                                          
  3   4.2  2490   20.0  15                                                                                                          
  4   4.4  2520   20.7  15                                                                                                          
  5   5.0  2490   21.9  15                                                                                                          
  6   5.0  2520   22.5  15                                                                                                          
  7   4.9  2520   22.6  15                                                                                                          
  8   5.3  2535   22.5  15                                                                                                          
  9   4.4  2475   22.8  15                                                                                                          
 10   5.1  2535   23.1  15                                                                                                          
 11   5.3  2555   23.6  15                                                                                                          
 12   5.0  2520   23.9  15                                                                                                          
 13   4.5  2520   23.9  15                                                                                                          
 14   5.6  2580   24.2  15                                                                                                          
 15   5.5  2460   24.8  15                                                                                                          
 16   5.1  2565   24.5  15                                                                                                          
 17   4.8  2460   25.6  15                                                                                                          
 18   4.5  2520   25.7  15                                                                                                          
 19   4.4  2535   25.8  15                                                                                                          
 20   5.1  2520   26.0  15                                                                                                          
 21   5.1  2505   26.5  15                                                                                                          
 22   4.8  2520   26.5  15                                                                                                          
 23   4.9  2505   26.7  15                                                                                                          
 24   4.6  2535   26.6  15                                                                                                          
 25   4.3  2520   26.2  15                                                                                                          
 26   4.5  2535   26.2  15                                                                                                          
 27   4.8  2490   26.7  15                                                                                                          
 28   4.6  2520   26.9  15                                                                                                          
 29   4.4  2550   26.7  15                                                                                                          
 30   4.4  2505   27.1  15                                                                                                          
 31   4.4  2505   27.5  15                                                                                                          
 32   4.5  2565   27.4  15                                                                                                          
 33   5.3  2505   27.6  15                                                                                                          
 34   4.3  2505   28.1  15                                                                                                          
 35   5.1  2550   27.8  15                                                                                                          
 36   5.1  2505   28.0  15                                                                                                          
 37   4.9  2535   27.7  15                                                                                                          
 38   5.1  2505   27.7  15                                                                                                          
 39   4.5  2520   27.8  15                                                                                                          
 40   5.1  2366   28.3  14                                                                                                          
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           21.9                                                                                                              
14 TO 52          26.7                                                                                                              
==============================                                                                                                      
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.