National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13054

TDMS Study 99039-01 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: BIORELIANCE                                 TRANSGENIC MODEL EVALUATION II                                     DATE: 02/21/03  
EXPERIMENT: 99039 TEST: 01                                                                                        TIME: 13:01:29    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: DOSED FEED                                             NTP:  C99039      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                         FINAL#3/TG.AC MICE                                                         
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    VEHICLE CONTROL                                                               
                                       INCLUDE 002    0.3%                                                                          
                                       INCLUDE 003    1.0 %                                                                         
                                       INCLUDE 004    3.0 %                                                                         
                                       INCLUDE 006    VEHICLE CONTROL                                                               
                                       INCLUDE 007    0.3 %                                                                         
                                       INCLUDE 008    1.0%                                                                          
                                       INCLUDE 009    3.0%                                                                          
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BIORELIANCE                                      TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)      DATE: 02/21/03    
EXPERIMENT: 99039 TEST: 01                                                                                        TIME: 13:09:30    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: 26                                       ROUTE: DOSED FEED                                             NTP:  C99039      
CONT: NO1-ES-75408                                                                                                CAS: 55589-62-3   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                         
                             26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                          
==================================================================================================================================  
      VEHICLE CONTROL                   0.3%                              1.0 %                              3.0 %                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     3.9    22.6       4.1     22.0    1.05      554      4.5     22.7    1.15     1978      4.6     22.5    1.18     6093       
  3     4.2    23.3       4.4     23.6    1.05      564      4.5     23.7    1.07     1901      4.6     23.7    1.10     5838       
  4     4.3    24.2       4.3     24.9    1.00      524      4.5     24.8    1.05     1817      4.6     24.7    1.07     5615       
  5     4.2    24.9       4.4     25.7    1.05      509      4.3     25.3    1.02     1686      4.4     25.1    1.05     5309       
  6     4.2    25.5       4.1     26.3    0.98      470      4.4     26.4    1.05     1659      4.5     25.6    1.07     5290       
  7     4.1    26.3       4.1     26.5    1.00      460      4.3     26.8    1.05     1607      4.5     26.9    1.10     5021       
  8     3.8    25.9       4.2     27.2    1.11      467      4.3     27.5    1.13     1567      4.5     27.4    1.18     4918       
  9     4.2    27.4       4.1     27.6    0.98      445      4.1     27.7    0.98     1464      4.3     27.7    1.02     4656       
 10     4.1    27.5       4.1     27.6    1.00      450      4.2     28.0    1.02     1515      4.4     27.7    1.07     4739       
 11     4.1    27.0       4.2     28.2    1.02      445      4.3     28.4    1.05     1528      4.4     27.6    1.07     4790       
 12     4.2    28.0       4.3     29.0    1.02      444      4.4     29.2    1.05     1502      4.6     28.8    1.10     4832       
 13     4.0    28.2       4.2     28.9    1.05      436      4.3     29.4    1.08     1463      4.5     29.0    1.13     4683       
 14     3.9    28.8       4.1     29.8    1.05      413      4.2     29.7    1.08     1418      4.5     29.3    1.15     4589       
 15     4.1    29.3       4.3     29.9    1.05      434      4.4     30.0    1.07     1458      4.6     29.9    1.12     4575       
 16     4.0    29.5       4.0     29.8    1.00      406      4.2     30.3    1.05     1402      4.5     30.1    1.13     4485       
 17     4.2    29.6       4.2     29.8    1.00      420      4.4     30.5    1.05     1454      4.7     30.4    1.12     4669       
 18     4.1    29.2       4.4     30.5    1.07      429      4.4     30.7    1.07     1440      4.5     30.6    1.10     4399       
 19     4.2    29.4       4.0     30.4    0.95      396      4.1     30.5    0.98     1331      4.5     30.7    1.07     4399       
 20     3.9    29.5       4.0     29.7    1.03      409      4.2     30.5    1.08     1391      4.4     30.6    1.13     4342       
 21     4.0    29.5       4.2     30.1    1.05      417      4.3     31.2    1.08     1367      4.4     31.1    1.10     4232       
 22     3.8    29.5       4.1     30.9    1.08      393      4.3     31.6    1.13     1359      4.6     31.5    1.21     4379       
 23     4.1    30.4       4.1     32.0    1.00      387      4.1     31.4    1.00     1298      4.4     31.8    1.07     4130       
 24     4.1    31.5       3.9     31.1    0.95      374      4.0     31.8    0.98     1242      4.4     31.9    1.07     4156       
 25     4.0    31.6       4.4     32.2    1.10      408      4.2     32.2    1.05     1299      4.4     32.1    1.10     4073       
 26     4.0    31.8       4.2     32.2    1.05      393      4.1     32.2    1.03     1264      4.5     32.8    1.13     4109       
 27     4.0    32.0       4.1     32.2    1.03      386      4.2     32.2    1.05     1318      4.4     32.3    1.10     4065       
 28     3.8    32.0       4.2     32.6    1.11      386      4.2     32.9    1.11     1276      4.4     32.8    1.16     4037       
 29     4.3    32.4       4.3     32.8    1.00      394      4.2     33.1    0.98     1280      4.3     32.5    1.00     3977       
 30     3.9    32.5       4.2     33.3    1.08      378      4.1     33.4    1.05     1231      4.3     33.0    1.10     3948       
 31     4.1    32.5       4.2     33.3    1.02      377      4.2     33.1    1.02     1266      4.2     33.0    1.02     3778       
 32     4.1    32.5       4.2     33.2    1.02      379      4.3     33.6    1.05     1287      4.7     33.7    1.15     4187       
 33     4.1    32.3       4.1     32.5    1.00      379      4.2     33.2    1.02     1280      4.3     33.0    1.05     3888       
 34     4.1    32.2       4.4     32.7    1.07      402      4.3     33.4    1.05     1281      4.4     33.4    1.07     3935       
 35     4.3    32.6       4.2     32.8    0.98      383      4.5     33.4    1.05     1346      4.3     33.4    1.00     3818       
 36     4.3    33.0       4.3     32.7    1.00      390      4.5     33.7    1.05     1325      4.5     33.4    1.05     4071       
 37     4.4    32.7       4.3     33.5    0.98      387      4.6     34.1    1.05     1344      4.6     33.3    1.05     4171       
 38     4.3    32.9       4.6     33.5    1.07      412      4.4     33.4    1.02     1318      4.6     33.2    1.07     4162       
 39     4.2    33.2       4.0     32.9    0.95      361      4.4     34.4    1.05     1275      4.6     33.9    1.10     4070       
 40     4.2    33.2       4.5     33.6    1.07      400      4.2     34.1    1.00     1245      4.5     33.5    1.07     4059       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.1    25.9       4.2     26.5    1.03      481      4.3     26.7    1.06     1641      4.5     26.4    1.09     5149       
SD(D)   0.1               0.1             0.04       45      0.1             0.05      174      0.1             0.05      482       
CV(E)   3.4               2.9             3.7       9.4      2.9             4.5      10.6      2.3             4.4       9.4       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.1    31.3       4.2     31.8    1.03      396      4.3     32.2    1.04     1326      4.5     32.1    1.09     4174       
SD(D)   0.1               0.2             0.05       18      0.1             0.04       66      0.1             0.05      236       
CV(E)   3.6               3.8             4.4       4.4      3.4             3.6       5.0      3.1             4.4       5.6       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                       
                             26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                          
==================================================================================================================================  
      VEHICLE CONTROL                  0.3 %                               1.0%                               3.0%                  
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      FEED/   WEIGHT     FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/  FEED/   WEIGHT  FEED (B)    DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     3.6    17.5       4.3     18.2     1.19     710      3.9     18.2     1.08    2160      4.5     18.1     1.25    7467       
  3     4.3    17.8       4.1     18.5     0.95     660      4.3     18.3     1.00    2339      4.0     18.3     0.93    6630       
  4     4.5    19.6       4.1     19.5     0.91     625      4.1     19.3     0.91    2106      4.1     19.7     0.91    6299       
  5     4.3    19.7       3.8     19.6     0.88     582      3.8     19.8     0.88    1944      3.9     19.7     0.91    5992       
  6     4.0    19.7       4.1     19.5     1.03     626      3.8     19.6     0.95    1948      4.1     19.4     1.03    6303       
  7     3.9    20.3       3.9     20.1     1.00     588      4.2     20.5     1.08    2029      4.1     20.6     1.05    5926       
  8     4.0    20.7       4.1     20.8     1.03     592      4.0     21.2     1.00    1902      4.0     20.8     1.00    5771       
  9     3.9    21.3       4.0     21.6     1.03     559      4.0     21.5     1.03    1875      4.0     21.2     1.03    5672       
 10     4.0    21.7       3.9     21.6     0.98     548      4.1     21.9     1.03    1880      4.2     21.4     1.05    5897       
 11     4.2    22.1       4.0     21.9     0.95     546      4.4     22.2     1.05    1960      4.4     22.3     1.05    5953       
 12     4.2    22.5       4.2     22.1     1.00     573      4.3     22.6     1.02    1892      4.2     21.9     1.00    5801       
 13     4.1    22.2       4.0     22.4     0.98     538      3.9     22.7     0.95    1737      4.2     21.9     1.02    5770       
 14     3.8    22.3       4.0     22.7     1.05     533      3.9     22.7     1.03    1719      4.0     22.1     1.05    5411       
 15     4.3    22.5       4.0     23.1     0.93     514      4.1     22.9     0.95    1785      3.9     22.6     0.91    5230       
 16     4.2    23.5       4.0     23.3     0.95     512      4.0     23.2     0.95    1705      4.2     23.4     1.00    5448       
 17     4.0    23.7       4.2     23.6     1.05     528      4.2     23.2     1.05    1828      4.1     23.0     1.03    5316       
 18     4.1    24.0       3.8     23.4     0.93     491      4.1     23.7     1.00    1738      4.2     23.3     1.02    5408       
 19     4.0    23.8       3.9     23.3     0.98     500      3.9     23.9     0.98    1615      4.1     23.3     1.03    5249       
 20     4.3    24.4       4.0     23.5     0.93     507      4.2     23.9     0.98    1760      4.3     23.7     1.00    5447       
 21     4.1    24.6       4.0     23.8     0.98     498      4.3     24.4     1.05    1781      3.7     23.5     0.90    4754       
 22     4.0    24.9       3.9     24.0     0.98     488      4.0     24.6     1.00    1628      3.9     23.3     0.98    5026       
 23     4.3    25.0       3.8     24.1     0.88     478      3.7     24.2     0.86    1544      4.5     24.0     1.05    5614       
 24     4.1    25.4       4.0     24.5     0.98     491      4.1     24.8     1.00    1641      4.1     24.7     1.00    4996       
 25     3.8    25.3       4.0     24.5     1.05     487      3.8     24.7     1.00    1527      4.0     25.1     1.05    4827       
 26     4.1    25.4       4.0     24.8     0.98     488      4.2     25.0     1.02    1668      4.2     25.2     1.02    4973       
 27     4.3    26.7       4.2     25.3     0.98     499      3.9     25.2     0.91    1545      4.0     25.1     0.93    4840       
 28     4.1    26.5       3.8     25.5     0.93     448      3.8     25.1     0.93    1525      4.1     25.1     1.00    4893       
 29     3.9    26.8       3.9     25.2     1.00     467      4.0     25.1     1.03    1597      3.9     24.8     1.00    4672       
 30     3.8    27.1       4.0     25.6     1.05     465      3.8     25.4     1.00    1483      4.1     25.7     1.08    4758       
 31     3.9    26.7       4.0     25.5     1.03     465      3.9     25.5     1.00    1536      4.1     26.1     1.05    4755       
 32     4.0    26.4       4.1     25.7     1.03     477      4.3     26.0     1.08    1641      4.3     26.1     1.08    4934       
 33     3.9    25.9       4.2     25.8     1.08     482      3.8     25.5     0.97    1502      4.1     25.8     1.05    4701       
 34     4.1    26.0       4.0     26.1     0.98     465      3.8     25.4     0.93    1493      4.2     25.6     1.02    4882       
 35     4.0    26.0       3.9     24.9     0.98     470      4.1     25.9     1.03    1586      4.4     26.4     1.10    5048       
 36     4.6    28.3       4.3     25.9     0.93     493      4.1     26.3     0.89    1573      4.4     26.2     0.96    5021       
 37     4.5    28.4       4.3     26.4     0.96     487      4.3     26.6     0.96    1615      4.2     26.3     0.93    4813       
 38     4.3    27.8       4.2     26.7     0.98     475      4.0     26.6     0.93    1508      4.5     26.6     1.05    5042       
 39     4.6    28.5       4.1     26.6     0.89     460      4.0     26.8     0.87    1491      4.2     26.7     0.91    4763       
 40     4.4    28.5       4.5     26.3     1.02     515      4.4     27.0     1.00    1639      4.3     26.6     0.98    4851       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    4.1    20.4       4.0     20.5     0.99     596      4.1     20.7     1.00    1981      4.2     20.4     1.02    6123       
SD(D)   0.2               0.1              0.08      51      0.2              0.06     158      0.2              0.09     506       
CV(E)   5.7               3.2              7.8      8.6      4.2              6.3      8.0      4.2              8.8      8.3       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.1    25.7       4.0     24.8     0.98     488      4.0     25.0     0.98    1618      4.2     24.8     1.01    5025       
SD(D)   0.2               0.2              0.05      21      0.2              0.06     102      0.2              0.05     270       
CV(E)   5.4               4.0              5.2      4.3      4.8              5.7      6.3      4.5              5.4      5.4       
==================================================================================================================================  
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.                                                                                      
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                     
                                                                                                                                   
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                DIAGNOSTIC TRAILER REPORT                                                                                           
                FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                                   
                26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                                       
=========================================================================================================                           
      VEHICLE CONTROL                0.3%                    1.0 %                    3.0 %                                         
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               21.2  15                 21.2  15                 21.3  15                 21.3  15                               
  1               21.2  15                 21.2  15                 21.3  15                 21.3  15                               
  2   3.9  2535   22.6  15     4.1  2535   22.0  15     4.5  2535   22.7  15     4.6  2535   22.5  15                               
  3   4.2  2505   23.3  15     4.4  2505   23.6  15     4.5  2505   23.7  15     4.6  2505   23.7  15                               
  4   4.3  2475   24.2  15     4.3  2475   24.9  15     4.5  2475   24.8  15     4.6  2476   24.7  15                               
  5   4.2  2535   24.9  15     4.4  2535   25.7  15     4.3  2535   25.3  15     4.4  2534   25.1  15                               
  6   4.2  2593   25.5  15     4.1  2595   26.3  15     4.4  2595   26.4  15     4.5  2595   25.6  15                               
  7   4.1  2475   26.3  15     4.1  2475   26.5  15     4.3  2475   26.8  15     4.5  2475   26.9  15                               
  8   3.8  2505   25.9  15     4.2  2505   27.2  15     4.3  2505   27.5  15     4.5  2505   27.4  15                               
  9   4.2  2535   27.4  15     4.1  2535   27.6  15     4.1  2535   27.7  15     4.3  2535   27.7  15                               
 10   4.1  2520   27.5  15     4.1  2520   27.6  15     4.2  2520   28.0  15     4.4  2520   27.7  15                               
 11   4.1  2520   27.0  15     4.2  2352   28.2  14     4.3  2520   28.4  15     4.4  2520   27.6  15                               
 12   4.2  2535   28.0  15     4.3  2366   29.0  14     4.4  2535   29.2  15     4.6  2535   28.8  15                               
 13   4.0  2505   28.2  15     4.2  2338   28.9  14     4.3  2505   29.4  15     4.5  2505   29.0  15                               
 14   3.9  2535   28.8  15     4.1  2366   29.8  14     4.2  2535   29.7  15     4.5  2535   29.3  15                               
 15   4.1  2520   29.3  15     4.3  2348   29.9  14     4.4  2520   30.0  15     4.6  2520   29.9  15                               
 16   4.0  2505   29.5  15     4.0  2338   29.8  14     4.2  2505   30.3  15     4.5  2505   30.1  15                               
 17   4.2  2535   29.6  15     4.2  2366   29.8  14     4.4  2535   30.5  15     4.7  2535   30.4  15                               
 18   4.1  2910   29.2  15     4.4  2716   30.5  14     4.4  2910   30.7  15     4.5  2910   30.6  15                               
 19   4.2  2130   29.4  15     4.0  1988   30.4  14     4.1  2130   30.5  15     4.5  2143   30.7  15                               
 20   3.9  2539   29.5  15     4.0  2380   29.7  14     4.2  2546   30.5  15     4.4  2535   30.6  15                               
 21   4.0  2554   29.5  15     4.2  2380   30.1  14     4.3  2550   31.2  15     4.4  2550   31.1  15                               
 22   3.8  2460   29.5  15     4.1  2296   30.9  14     4.3  2460   31.6  15     4.6  2460   31.5  15                               
 23   4.1  2352   30.4  14     4.1  2184   32.0  13     4.1  2520   31.4  15     4.4  2520   31.8  15                               
 24   4.1  2184   31.5  13     3.9  2184   31.1  13     4.0  2520   31.8  15     4.4  2520   31.9  15                               
 25   4.0  2184   31.6  13     4.4  2184   32.2  13     4.2  2520   32.2  15     4.4  2520   32.1  15                               
 26   4.0  2184   31.8  13     4.2  2184   32.2  13     4.1  2520   32.2  15     4.5  2347   32.8  14                               
 27   4.0  2184   32.0  13     4.1  2197   32.2  13     4.2  2535   32.2  15     4.4  2352   32.3  14                               
 28   3.8  2197   32.0  13     4.2  2184   32.6  13     4.2  2535   32.9  15     4.4  2197   32.8  14                               
 29   4.3  2197   32.4  13     4.3  2210   32.8  13     4.2  2370   33.1  14     4.3  2370   32.5  14                               
 30   3.9  2158   32.5  13     4.2  2158   33.3  13     4.1  2324   33.4  14     4.3  2324   33.0  14                               
 31   4.1  2171   32.5  13     4.2  2171   33.3  13     4.2  2338   33.1  14     4.2  2171   33.0  14                               
 32   4.1  2052   32.5  13     4.2  2223   33.2  13     4.3  2394   33.6  14     4.7  2380   33.7  14                               
 33   4.1  2004   32.3  13     4.1  2171   32.5  13     4.2  2338   33.2  14     4.3  2352   33.0  14                               
 34   4.1  2171   32.2  13     4.4  2171   32.7  13     4.3  2338   33.4  14     4.4  2338   33.4  14                               
 35   4.3  2184   32.6  13     4.2  2016   32.8  12     4.5  2352   33.4  14     4.3  2184   33.4  14                               
 36   4.3  2184   33.0  13     4.3  2016   32.7  12     4.5  2352   33.7  14     4.5  2352   33.4  14                               
 37   4.4  2184   32.7  13     4.3  2016   33.5  12     4.6  2352   34.1  14     4.6  2352   33.3  14                               
 38   4.3  2197   32.9  13     4.6  2028   33.5  12     4.4  2366   33.4  14     4.6  2366   33.2  14                               
 39   4.2  2171   33.2  13     4.0  2004   32.9  12     4.4  2004   34.4  13     4.6  2338   33.9  14                               
 40   4.2  2158   33.2  13     4.5  1826   33.6  11     4.2  2158   34.1  13     4.5  2324   33.5  14                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           25.5                     26.1                     26.2                     26.0                                   
14 TO 52          31.3                     31.8                     32.2                     32.1                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                DIAGNOSTIC TRAILER REPORT                                                                                           
                FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                                 
                26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)                                       
=========================================================================================================                           
      VEHICLE CONTROL               0.3 %                     1.0%                     3.0%                                         
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM    DAILY FEED  BODY  NUM                               
WEEK FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS   FEED HOURS   WGT  WGTS                              
==========================================================================================================                          
  B               17.9  15                 17.8  15                 18.0  15                 17.8  15                               
  1               17.9  15                 17.8  15                 18.0  15                 17.8  15                               
  2   3.6  2494   17.5  15     4.3  2505   18.2  15     3.9  2505   18.2  15     4.5  2505   18.1  15                               
  3   4.3  2520   17.8  15     4.1  2520   18.5  15     4.3  2511   18.3  15     4.0  2505   18.3  15                               
  4   4.5  2550   19.6  15     4.1  2550   19.5  15     4.1  2550   19.3  15     4.1  2550   19.7  15                               
  5   4.3  2462   19.7  15     3.8  2474   19.6  15     3.8  2475   19.8  15     3.9  2475   19.7  15                               
  6   4.0  2549   19.7  15     4.1  2543   19.5  15     3.8  2535   19.6  15     4.1  2547   19.4  15                               
  7   3.9  2529   20.3  15     3.9  2520   20.1  15     4.2  2520   20.5  15     4.1  2520   20.6  15                               
  8   4.0  2519   20.7  15     4.1  2520   20.8  15     4.0  2520   21.2  15     4.0  2520   20.8  15                               
  9   3.9  2520   21.3  15     4.0  2520   21.6  15     4.0  2520   21.5  15     4.0  2520   21.2  15                               
 10   4.0  2520   21.7  15     3.9  2520   21.6  15     4.1  2520   21.9  15     4.2  2520   21.4  15                               
 11   4.2  2535   22.1  15     4.0  2521   21.9  15     4.4  2520   22.2  15     4.4  2520   22.3  15                               
 12   4.2  2520   22.5  15     4.2  2352   22.1  14     4.3  2352   22.6  15     4.2  2520   21.9  15                               
 13   4.1  2520   22.2  15     4.0  2352   22.4  14     3.9  2520   22.7  15     4.2  2520   21.9  15                               
 14   3.8  2520   22.3  15     4.0  2352   22.7  14     3.9  2520   22.7  15     4.0  2520   22.1  15                               
 15   4.3  2536   22.5  15     4.0  2366   23.1  14     4.1  2535   22.9  15     3.9  2535   22.6  15                               
 16   4.2  2519   23.5  15     4.0  2352   23.3  14     4.0  2520   23.2  15     4.2  2520   23.4  15                               
 17   4.0  2519   23.7  15     4.2  2352   23.6  14     4.2  2520   23.2  15     4.1  2520   23.0  15                               
 18   4.1  2535   24.0  15     3.8  2366   23.4  14     4.1  2535   23.7  15     4.2  2535   23.3  15                               
 19   4.0  2505   23.8  15     3.9  2338   23.3  14     3.9  2505   23.9  15     4.1  2512   23.3  15                               
 20   4.3  2535   24.4  15     4.0  2366   23.5  14     4.2  2535   23.9  15     4.3  2535   23.7  15                               
 21   4.1  2505   24.6  15     4.0  2338   23.8  14     4.3  2505   24.4  15     3.7  2505   23.5  15                               
 22   4.0  2520   24.9  15     3.9  2352   24.0  14     4.0  2520   24.6  15     3.9  2520   23.3  15                               
 23   4.3  2505   25.0  15     3.8  2338   24.1  14     3.7  2505   24.2  15     4.5  2505   24.0  15                               
 24   4.1  2535   25.4  15     4.0  2366   24.5  14     4.1  2535   24.8  15     4.1  2366   24.7  14                               
 25   3.8  2520   25.3  15     4.0  2352   24.5  14     3.8  2520   24.7  15     4.0  2352   25.1  14                               
 26   4.1  2520   25.4  15     4.0  2338   24.8  14     4.2  2505   25.0  15     4.2  2338   25.2  14                               
 27   4.3  2520   26.7  15     4.2  2366   25.3  14     3.9  2535   25.2  15     4.0  2352   25.1  14                               
 28   4.1  2535   26.5  15     3.8  2352   25.5  14     3.8  2520   25.1  15     4.1  2366   25.1  14                               
 29   3.9  2505   26.8  15     3.9  2171   25.2  13     4.0  2505   25.1  15     3.9  2338   24.8  14                               
 30   3.8  2520   27.1  15     4.0  2184   25.6  13     3.8  2520   25.4  15     4.1  2352   25.7  14                               
 31   3.9  2520   26.7  15     4.0  2184   25.5  13     3.9  2356   25.5  14     4.1  2352   26.1  14                               
 32   4.0  2564   26.4  15     4.1  2223   25.7  13     4.3  2394   26.0  14     4.3  2380   26.1  14                               
 33   3.9  2324   25.9  14     4.2  2145   25.8  13     3.8  2324   25.5  14     4.1  2338   25.8  14                               
 34   4.1  2352   26.0  14     4.0  2184   26.1  13     3.8  2352   25.4  14     4.2  2352   25.6  14                               
 35   4.0  2184   26.0  13     3.9  2184   24.9  13     4.1  2184   25.9  13     4.4  2184   26.4  13                               
 36   4.6  2005   28.3  12     4.3  2171   25.9  13     4.1  2171   26.3  13     4.4  2171   26.2  13                               
 37   4.5  2016   28.4  12     4.3  2184   26.4  13     4.3  2184   26.6  13     4.2  2184   26.3  13                               
 38   4.3  2016   27.8  12     4.2  2016   26.7  12     4.0  2184   26.6  13     4.5  2016   26.6  12                               
 39   4.6  2016   28.5  12     4.1  2016   26.6  12     4.0  2184   26.8  13     4.2  2016   26.7  12                               
 40   4.4  1992   28.5  12     4.5  1992   26.3  12     4.4  1992   27.0  12     4.3  1992   26.6  12                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           20.2                     20.3                     20.5                     20.2                                   
14 TO 52          25.7                     24.8                     25.0                     24.8                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.