Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/14525

TDMS Study 99039-01 Pathology Tables

NTP Experiment-Test: 99039-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/21/03
Route: DOSED FEED                            TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)               Time: 10:27:24

                                                       FINAL#3/TG.AC MICE




       Facility:  BIORELIANCE

       Chemical CAS #:  55589-62-3

       Lock Date:  07/20/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include 001    VEHICLE CONTROL
                               Include 002    0.3%
                               Include 003    1.0 %
                               Include 004    3.0 %
                               Include 006    VEHICLE CONTROL
                               Include 007    0.3 %
                               Include 008    1.0%
                               Include 009    3.0%


























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 99039-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/21/03    
Route: DOSED FEED                            TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)               Time: 10:27:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               VEHICLE      0.3 %        1.0%         3.0%                                   
                                                      CONTROL                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1                         2            2                                     
    Natural Death                                      2            3            1            1                                     
  Survivors                                                                                                                         
    Accidently Killed                                  4            3            1                                                  
    Terminal Sacrifice                                 8            9           11           12                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           14           14           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (2)                       (15)                                   
      Inflammation, Chronic                            2 [1.0]                                3 [1.3]                               
      Necrosis, Focal                                  1 [1.0]                                                                      
      Tension Lipidosis, Focal                                                                1 [1.0]                               
      Hepatocyte, Inflammation, Chronic                1 [1.0]                                                                      
      Hepatocyte, Necrosis, Focal                      2 [1.0]                                3 [1.0]                               
   Mesentery                                          (2)                       (1)                                                 
      Fat, Inflammation, Acute, Focal                                            1 [4.0]                                            
      Fat, Necrosis, Focal                             2 [4.0]                                                                      
   Tongue                                             (15)         (1)                       (15)                                   
      Ulcer                                            1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (14)         (1)                       (15)                                   
      Subcapsular, Hyperplasia, Focal                  9 [1.0]                                6 [1.0]                               
      Zona Reticularis, Vacuolization Cytoplasmic      9 [1.7]                               10 [1.6]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 99039-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/21/03    
Route: DOSED FEED                            TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)               Time: 10:27:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               VEHICLE      0.3 %        1.0%         3.0%                                   
                                                      CONTROL                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Uterus                                             (13)         (2)          (1)          (14)                                   
      Endometrium, Hyperplasia, Cystic                 7 [1.9]      2 [2.5]      1 [3.0]     10 [1.7]                               
   Vagina                                             (13)                                   (15)                                   
      Hyperplasia                                      1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (12)         (1)                       (15)                                   
      Hyperplasia                                      1 [2.0]                                3 [2.0]                               
   Spleen                                             (15)                      (3)          (15)                                   
      Hematopoietic Cell Proliferation                12 [1.5]                   3 [2.7]     13 [2.0]                               
      Pigmentation                                     3 [1.3]                                2 [1.0]                               
   Thymus                                             (11)         (1)                       (14)                                   
      Atrophy, Diffuse                                 1 [3.0]                                1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (14)         (2)          (1)          (15)                                   
      Mandible, Inflammation, Chronic Active                        1 [2.0]                   1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)                                   (15)                                   
      Hemorrhage, Focal                                                                       1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 99039-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/21/03    
Route: DOSED FEED                            TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)               Time: 10:27:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               VEHICLE      0.3 %        1.0%         3.0%                                   
                                                      CONTROL                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
   Eye                                                (13)                                   (14)                                   
      Retina, Atrophy                                 13 [3.0]                               14 [3.0]                               
   Harderian Gland                                    (14)         (1)                       (15)                                   
      Infiltration Cellular, Focal, Lymphocyte         1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (1)                       (15)                                   
      Renal Tubule, Dilatation, Focal                                                         1 [1.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 99039-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/21/03    
Route: DOSED FEED                            TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)               Time: 10:27:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 VEHICLE      0.3%         1.0 %        3.0 %                                  
                                                      CONTROL                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            4            2            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 6            9            7           11                                     
    Accidently Killed                                  7            2            6            3                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)                      (1)          (15)                                   
      Hematopoietic Cell Proliferation                 1 [1.0]                                                                      
      Inflammation, Chronic                            1 [1.0]                                                                      
      Hepatocyte, Necrosis, Focal                      1 [1.0]                                                                      
   Mesentery                                          (2)                                    (2)                                    
      Fat, Necrosis, Focal                             2 [4.0]                                2 [1.0]                               
   Pancreas                                           (15)                                   (15)                                   
      Inflammation, Chronic Active                     1 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (14)                                   (15)                                   
      Atrophy                                         10 [2.4]                               11 [2.5]                               
      Hypertrophy, Focal                               9 [1.2]                                5 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (15)                      (1)          (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 99039-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/21/03    
Route: DOSED FEED                            TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)               Time: 10:27:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 VEHICLE      0.3%         1.0 %        3.0 %                                  
                                                      CONTROL                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cyst                                             1 [1.0]                   1 [3.0]                                            
   Testes                                             (15)                                   (15)                                   
      Germinal Epithelium, Degeneration, Focal         1 [3.0]                                1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (15)                                   (15)                                   
      Hyperplasia                                                                             1 [1.0]                               
   Lymph Node, Mandibular                             (14)                                   (15)                                   
      Hyperplasia                                      2 [3.0]                                2 [2.0]                               
   Spleen                                             (15)         (1)          (1)          (15)                                   
      Atrophy                                          1 [4.0]                                                                      
      Hematopoietic Cell Proliferation                10 [1.6]      1 [3.0]                   7 [1.1]                               
   Thymus                                             (15)                                   (14)                                   
      Atrophy, Diffuse                                 3 [3.7]                                2 [2.5]                               
      Atrophy, Focal                                   2 [1.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (7)          (8)          (15)                                   
      Sebaceous Gland, Hyperplasia, Focal              1 [1.0]                                                                      
      Subcutaneous Tissue, Pinna, Inflammation,                                                                                     
         Acute, Focal                                               1 [4.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Alveolar Epithelium, Alveolus, Inflammation,                                                                                  
         Chronic Active, Focal                                                                1 [1.0]                               
   Nose                                               (15)                                   (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 99039-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 02/21/03    
Route: DOSED FEED                            TRANSGENIC MODEL EVALUATION II  (ACESULFAME POTASSIUM)               Time: 10:27:24    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 VEHICLE      0.3%         1.0 %        3.0 %                                  
                                                      CONTROL                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Glands, Hyperplasia                              1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (15)                                   (15)                                   
      Retina, Atrophy                                 15 [3.0]                               14 [3.1]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (1)                       (15)                                   
      Infiltration Cellular, Plasma Cell                            1 [3.0]                                                         
      Renal Tubule, Dilatation, Diffuse                                                       1 [4.0]                               
      Renal Tubule, Dilatation, Focal                                                         2 [1.5]                               
   Urinary Bladder                                    (15)                                   (15)                                   
      Edema                                            1 [3.0]                                                                      
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------