Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/11429

NCTR Study 211601 Pathology Tables

NCTR EXP/TEST:   211601                                                                                      PAGE:    1
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |  2                                                                        |          |
  ULCER                                     |           3                                                               |          |
GALLBLADDER                                 | +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                          1|          |
INTESTINE LARGE                             | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  A  M  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,COLON                       | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  EROSION                                   |                                                                           |          |
INTESTINE SMALL                             | +  +  A  A  +  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  +  A  A  +  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
INTESTINE SMALL,ILEUM                       | +  +  A  A  +  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                       2   |          |
INTESTINE SMALL,JEJUNUM                     | +  +  A  A  +  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                    1                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1        1  1              1  1  1  1  1  1  1  1  2     1     1  2  1|          |
  INFLAMMATION                              |                                1                                          |          |
  NECROSIS                                  |     1                          1  2  1  1     1        1  1  1     1  1  1|          |
  NECROSIS,COAGULATIVE                      |                    2                                                      |          |
  TENSION LIPOIDOSIS                        |                                              X              X  X  X  X  X |          |
  VACUOLIZATION CYTOPLASMIC                 |        1     1     1        1                             1     1     1  1|          |
MESENTERY                                   |                            +                                              |          |
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                           |          |
  FOCAL CELLULAR CHANGE                     |        1                                                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     2  1                    1  1  1           1  1  1  1  1     1  1|          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,DUCT                          |  3                                                                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1           1  1  2     1     2  2  1  1  1  2  2     1     1  1  1|          |
STOMACH                                     | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,GLANDULAR                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    2
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CRYSTALS                                  |                                                                           |          |
  CYST                                      |                                                                           |          |
  DEGENERATION,HYALINE                      |                                                                           |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,MAST CELL           |                                                                 2         |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  M  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |        1                                                                  |          |
  INFLAMMATION                              |           4                                                               |          |
  POLYARTERITIS                             |                                                                           |          |
  THROMBUS                                  |        4                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                                           |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTOPIC TISSUE                            |                               X                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |     1  3     2  2     1  2     2     2  2  2  3  2  2  2  2  2  2  3  2  2|          |
  THROMBUS                                  |        2                                                                  |          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  VACUOLIZATION CYTOPLASMIC                 |                                         2                                 |          |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  M  +  M  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  ECTOPIC THYMUS                            |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      3                                    |          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
PITUITARY GLAND                             | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,PARS DISTALIS                 |                                1                    3        1            |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    3
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  DEGENERATION                              |              2                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1        1|          |
  ULTIMOBRANCHIAL CYST                      |                    3           2     2  2     2                          3|          |
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |                                                                +          |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | M  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |        4        4  3     3  4     4  4  2  3  4  3  2     4  3  4  4  3  4|          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   | X     X  X  X     X  X  X     X     X     X  X  X     X  X  X  X  X  X    |          |
  CONGESTION                                |                                      2                                    |          |
  CYST                                      |                                  X     X     X     X                    X |          |
  CYST,PERIOVARIAN TISSUE                   |       X                 X              X  X  X                 X          |          |
  HEMATOCYST                                |                                                             X     X       |          |
  HYPERPLASIA,ADENOMATOUS                   |                                4  4                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      2                                    |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |  3        4                                                               |          |
  DILATATION                                |                    3                                                      |          |
  FIBROSIS                                  |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |     1  2        2           2  3     3  3  3  3  3  2  2  2  3  2  1  2  3|          |
  PROLAPSE                                  |                                                                           |          |
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |  3        4                                                               |          |
  DYSPLASIA                                 |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |           3           3                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    4
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                          2           2                 2              2   |          |
LYMPH NODE,MESENTERIC                       | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                     2                     |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                                2        2                                 |          |
SPLEEN                                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           3        3                                                      |          |
  HEMATOPOIETIC CELL PROLIFERATION          |           3        3     3                                                |          |
  HYPERPLASIA,LYMPHOID                      |              2                          2  2        1        3            |          |
THYMUS                                      | M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
  ATROPHY,CORTEX                            |        4     3  3  4           3  3  3  3  4  3  3  3     4  3  4  3  2   |          |
  CONGESTION                                |                                               2                           |          |
  ECTOPIC PARATHYROID GLAND                 |                                                          X                |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                      2        2     1     2  2     3     3|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  + |          |
  HYPERPLASIA                               |              2                                                            |          |
  INFLAMMATION                              |                                                                           |          |
  LACTATION                                 |        2                                                        2         |          |
SKIN                                        | +  +  +  +  M  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                                         2        2        4     1     2  2|          |
BONE,STERNUM                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |        2           1  2        3  3     3  2  3  3  2  2  2  1  2  1  2  3|          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                    1                          2                           |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    5
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |        2                                                                  |          |
  THROMBUS                                  |        3                                                                  |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |        2                                                                  |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1        1     1           1     1        1  1  1  1  2           1|          |
  THROMBUS                                  |        3                                                                  |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |     3                                                                     |          |
  THROMBUS                                  |        2                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FOREIGN BODY                              |       X                                                                   |          |
  HEMORRHAGE                                |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1     1  1     2     2  2  1  1  1  1  1     1        1  2|          |
  INFLAMMATION                              |        4  4                                            1                  |          |
  THROMBUS                                  |        4                                                                  |          |
NOSE                                        | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST,NASOLACRIMAL DUCT                    |                                                                           |          |
  INFLAMMATION                              |           3                                                               |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |  4                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  A  +  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
  DEGENERATION,RETINA                       |                                                                           |          |
  THROMBUS                                  |        3                                                                  |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    6
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:32.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1           1  1  1              1  1     1     1|          |
  THROMBUS                                  |        2                                                                  |          |
LACRIMAL GLAND                              | +  +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  + |          |
  ATROPHY                                   |                                                  4                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1                 1     2  1  1  1  3  1  2     1     1  1   |          |
ZYMBAL'S GLAND                              | +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |     2                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                        3                  |          |
  CONGESTION                                |           1                                                               |          |
  CYST,RENAL TUBULE                         |              1                          2                 1        1     1|          |
  HYDRONEPHROSIS,BILATERAL                  |                          2                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1     2  1        2  1  2  1  1  1  1  1  2  1  2     1  1  1|          |
  INFLAMMATION                              |                                                                           |          |
  NEPHROPATHY                               |                                1           1                             1|          |
  POLYARTERITIS                             |                                                                           |          |
URINARY BLADDER                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1     1  1  1     1  1  1  1  1  1  1  1  2     2     1  1  1|          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    7
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:44.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
  ULCER                                     |                                                                           |     1 3.0|
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                       1     1                                       |     4 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
  HYPERPLASIA,LYMPHOID                      |                    2              2                 2     2     2         |     5 2.0|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +       | 44       |
  EROSION                                   |           2     2                                                         |     2 2.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 41       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 40       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 40       |
  HYPERPLASIA,LYMPHOID                      |                                            2                              |     2 2.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 41       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                                  X                                        |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |     1           1                                                         |     3 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  1  1  1  1  1  1        1  1  1  1  1  2  2  1     3               |    33 1.2|
  INFLAMMATION                              |                                                           1               |     2 1.0|
  NECROSIS                                  |  1  1     1  1  1  1  1  1  1  1  1     1  1  1     1  1  1  1  1  1      |    32 1.0|
  NECROSIS,COAGULATIVE                      |                                                                           |     1 2.0|
  TENSION LIPOIDOSIS                        | X     X           X  X           X  X  X     X     X           X  X       |    17    |
  VACUOLIZATION CYTOPLASMIC                 |        1  1  1  1  1  1  2  2  1  1  1  2  2  1     1  1  1     1         |    26 1.1|
MESENTERY                                   |                                                                           |  1       |
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |                                      2                                    |     1 2.0|
  FOCAL CELLULAR CHANGE                     |                                                              1            |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1     1  1  1  1  1     1              1     1        1  1      |    26 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA,DUCT                          |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  2  1  2  2  1  2  2  2  1  2  1  1     1  1  1  1  1  2  1      |    38 1.3|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    8
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CRYSTALS                                  |                                                           2               |     1 2.0|
  CYST                                      |  1                                                     1                  |     2 1.0|
  DEGENERATION,HYALINE                      |                                                           2               |     1 2.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,MAST CELL           |                                                           2               |     2 2.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 1.0|
  INFLAMMATION                              |                                                                           |     1 4.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
  THROMBUS                                  |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                       X                   |     1    |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ECTOPIC TISSUE                            |                                                                           |     1    |
  HYPERPLASIA,SPINDLE CELL                  |  2  2  2  2  2  2  2  2  2  2  2  1  3  2  3  2  2  3  2  2  1  2  2      |    43 2.0|
  THROMBUS                                  |                                                                           |     1 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                                2           2                              |     2 2.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
PARATHYROID GLAND                           | +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +       | 38       |
  ECTOPIC THYMUS                            |                                                                X          |     1    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 3.0|
  VACUOLIZATION CYTOPLASMIC                 |                                            2                              |     1 2.0|
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +       | 45       |
  HYPERPLASIA,PARS DISTALIS                 |              1                                                            |     4 1.5|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    9
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  DEGENERATION                              |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2                 1                                                |     4 1.2|
  ULTIMOBRANCHIAL CYST                      |              2           2                 2  2     2                     |    11 2.1|
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  ATROPHY                                   |  4  3  4  3  3  3  4  4  3     4  3  3  4  3  4  4  3  3  3  3  2  3      |    40 3.3|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   | X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X       |    39    |
  CONGESTION                                |                                                                           |     1 2.0|
  CYST                                      |             X  X     X        X                                   X       |    10    |
  CYST,PERIOVARIAN TISSUE                   | X  X     X  X                       X        X  X  X     X     X          |    16    |
  HEMATOCYST                                |          X              X           X  X                 X                |     7    |
  HYPERPLASIA,ADENOMATOUS                   |                                                                           |     2 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          3  1        2  2                                 |     5 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |     2                                                                     |     1 2.0|
  ATROPHY                                   |                                                                           |     2 3.5|
  DILATATION                                |  4                                                                        |     2 3.5|
  FIBROSIS                                  |              2                                                            |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |     2     3  3  2  3  2  2  2  1  2  2  3  2  3  3  2  2  1     2         |    37 2.2|
  PROLAPSE                                  |       X                                                                   |     1    |
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |                                                                           |     2 3.5|
  DYSPLASIA                                 |                       2                                                   |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1  2              1                              |     3 1.3|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |              2                                                            |     3 2.6|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   10
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HEMORRHAGE                                |                    2                 2        2                           |     3 2.0|
  HYPERPLASIA,LYMPHOID                      |              3     3                             2                        |     7 2.2|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                    2                                                      |     2 2.0|
  HEMORRHAGE                                |     3                                         1     2     1               |     4 1.7|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     2 2.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                                                           |     2 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                       2                                                   |     4 2.7|
  HYPERPLASIA,LYMPHOID                      |        1  1  3  1  3     2  3                 4                           |    13 2.1|
THYMUS                                      | +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +       | 41       |
  ATROPHY,CORTEX                            |  3     4  4     3        3     2        3        2  3  2  2  2  2         |    30 3.0|
  CONGESTION                                |                                                                           |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |     3        2           4              2  2        3        1            |    14 2.2|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  INFLAMMATION                              |                                            1                              |     1 1.0|
  LACTATION                                 |                                            2           2                  |     4 2.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROUS OSTEODYSTROPHY                    |  2        2  2        1  2  1     2  1     2  2  2     1                  |    18 1.8|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  2     3  2  3  1  3  3  2  2  1  1  1  4        3  2  3  4  1     1      |    36 2.1|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.5|
  POLYARTERITIS                             |     2                                                                     |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   11
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 2.0|
  THROMBUS                                  |                                                                           |     1 3.0|
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 2.0|
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1           1  2  1  1     1     1  2  1  2  1     1  1  1  1  1  1      |    28 1.1|
  THROMBUS                                  |                                                                           |     1 3.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 3.0|
  THROMBUS                                  |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1                                                |     1 1.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FOREIGN BODY                              |                                                                           |     1    |
  HEMORRHAGE                                |                       2        2                                          |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  1  2  1  1  1  2  2  3  1  2  2  1  1  1  2  1  1  1  1  1         |    37 1.3|
  INFLAMMATION                              |                       1                                                   |     4 2.5|
  THROMBUS                                  |                                                                           |     1 4.0|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CYST,NASOLACRIMAL DUCT                    |                 2                                                         |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 3.0|
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  INFLAMMATION                              |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 41       |
  DEGENERATION,RETINA                       |                                      4                                    |     1 4.0|
  THROMBUS                                  |                                                                           |     1 3.0|
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   12
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1  1           1  1     1  1     1     1  2     1         |    18 1.0|
  THROMBUS                                  |                                                                           |     1 2.0|
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M       | 41       |
  ATROPHY                                   |                                                                           |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1  2  1  2        2  1  1        1     1        1     1         |    25 1.2|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +       | 43       |
  INFLAMMATION                              |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                           2               |     2 2.5|
  CONGESTION                                |                                                                           |     1 1.0|
  CYST,RENAL TUBULE                         |           1           1     2     1        1     1        1  1     1      |    14 1.1|
  HYDRONEPHROSIS,BILATERAL                  |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  2  2  1  1     1  1  1  1  1  1  1  1  1  1  2  1     1  1         |    39 1.2|
  INFLAMMATION                              |                                                           1               |     1 1.0|
  NEPHROPATHY                               |                                                                           |     3 1.0|
  POLYARTERITIS                             |     2                                                                     |     1 2.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  1  1  1  2  2  1  1  1  1  1  1  2     1  1  1  1         |    38 1.1|
  POLYARTERITIS                             |     2                                                                     |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   13
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  M                    +  +                               |          |
GALLBLADDER                                 | +  +  +  +  +  +  M                    +  +                               |          |
INTESTINE LARGE                             | +  A  +  +  +  +  +                    +  +                               |          |
INTESTINE LARGE,CECUM                       | +  A  +  A  +  +  A                    +  +                               |          |
INTESTINE LARGE,COLON                       | +  A  +  +  +  +  +                    +  +                               |          |
INTESTINE LARGE,RECTUM                      | +  A  +  M  +  +  +                    +  +                               |          |
INTESTINE SMALL                             | +  A  +  A  +  +  A                    +  +                               |          |
INTESTINE SMALL,DUODENUM                    | +  A  +  A  +  +  A                    +  +                               |          |
INTESTINE SMALL,ILEUM                       | +  A  +  A  +  +  A                    +  +                               |          |
INTESTINE SMALL,JEJUNUM                     | +  A  +  A  +  +  A                    +  +                               |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                               1                           |          |
  BASOPHILIC FOCUS                          |                            X                                              |          |
  CLEAR CELL FOCUS                          |                                                 X                         |          |
  EOSINOPHILIC FOCUS                        |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  1  1  1        1                       1     1     1           1  1      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1     2  1  1  2  1  3  1     2  1  2  1  1  2  1  1      |          |
  NECROSIS                                  |     1        1        1  1  1  1  1  1        1  1  1  1  1     1  2  1  1|          |
  TENSION LIPOIDOSIS                        |                         X  X     X           X        X     X     X       |          |
  VACUOLIZATION CYTOPLASMIC                 |  2     2     3        3  2  3  1        2  1  1  1  1  2  2  2        1  1|          |
MESENTERY                                   |                                                                           |          |
  NECROSIS,FAT                              |                                                                           |          |
PANCREAS                                    | M  +  +  A  +  +  +                    +  +                               |          |
  ATROPHY                                   |                 1                                                         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1                             1                              |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +                    +  +                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1  1                       1  1                              |          |
STOMACH                                     | +  +  +  +  +  +  +                    +  +                               |          |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +                    +  +                               |          |
  HYPERKERATOSIS                            |           2        2                    2                                 |          |
  ULCER                                     |                                            2                              |          |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +                    +  +                               |          |
  MINERALIZATION                            |                                         2                                 |          |
TONGUE                                      | +  +  +  +  +  +  +                    A  +                               |          |
  INFLAMMATION                              |        2                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   14
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  M  +  +  +                    +  +                               |          |
BLOOD VESSEL,AORTA                          | +  +  +  M  +  +  +                    +  +                               |          |
  MINERALIZATION                            |                                         4                                 |          |
HEART                                       | +  +  +  +  +  +  +                    +  +                               |          |
  DEGENERATION                              |                                                                           |          |
  DILATATION                                |                 3                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  M  +  +  +  +  +                    +  +                               |          |
ADRENAL GLAND,CORTEX                        | +  M  +  +  +  +  +                    +  +                               |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  2  1  2                       2  2                              |          |
ADRENAL GLAND,MEDULLA                       | +  M  +  +  +  +  +                    +  +                               |          |
ISLETS, PANCREATIC                          | M  +  +  A  +  +  +                    +  +                               |          |
PARATHYROID GLAND                           | M  +  +  +  +  +  +                    +  +                               |          |
PITUITARY GLAND                             | M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                     1  1           1      |          |
THYROID GLAND                               | M  +  +  +  +  +  +                    +  +                               |          |
  CYST,FOLLICLE                             |                                            2                              |          |
  DEGENERATION                              |                                                                           |          |
  HYPERPLASIA,FOLLICULAR CELL               |                    4                                                      |          |
  ULTIMOBRANCHIAL CYST                      |                 3                       3                                 |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | M  M  +  +  +  +  +                    +  +                               |          |
  ATROPHY                                   |           3     4  4                    3  3                              |          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +                |          |
  ATROPHY                                   | X  X  X        X                       X  X                               |          |
  CYST                                      |          X  X        X           X  X              X  X                   |          |
  CYST,PERIOVARIAN TISSUE                   |    X                       X  X                          X                |          |
  HEMATOCYST                                |                         X           X                                     |          |
  MINERALIZATION                            |                          4                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   15
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

UTERUS                                      | +  +  +  +  +  +  +              +     +  +        +  +     +     +       |          |
  ATROPHY                                   |  3        4     4  4                    2                                 |          |
  DILATATION                                |                                                                           |          |
  FIBROSIS                                  |                                   2                                       |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2                    3                 3  3     2     2      |          |
  INFLAMMATION                              |        4                                                                  |          |
VAGINA                                      | +  +  +  +  +  M  +                    +  +                               |          |
  ATROPHY                                   |           4        4                    2                                 |          |
  DYSPLASIA                                 |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +                    +  +                               |          |
  HYPERPLASIA                               |  4  3  3                                2                                 |          |
LYMPH NODE                                  | +  +  +  +  +  +  +                    +  +                               |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +                    +  +                               |          |
  HEMORRHAGE                                |     2     2     2                                                         |          |
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                            3                              |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  M  +  A                    +  +                               |          |
  ATROPHY                                   |                                         4  3                              |          |
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |          |
SPLEEN                                      | +  +  +  +  +  +  +        +           +  +  +                            |          |
  ATROPHY                                   |                 3                       2                                 |          |
  CONGESTION                                |                                            1                              |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  4  4           4                                                         |          |
  HYPERPLASIA,LYMPHOID                      |              1              2           2     1                           |          |
THYMUS                                      | +  M  M  +  +  +  M                    M  +                               |          |
  ATROPHY,CORTEX                            |              3  4                          4                              |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |              2                                                            |          |
  INFLAMMATION                              |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  +  M  +  +  +                    +  +                               |          |
  HYPERPLASIA                               |        3                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   16
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

  LACTATION                                 |                    2                                                      |          |
SKIN                                        | +  +  +  +  +  +  +                    +  +                               |          |
  EDEMA                                     |                 3                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +                    +  +                               |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +                    +  +                               |          |
BONE,STERNUM                                | +  +  +  +  +  +  +                    +  +                               |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |        2                                1  1                              |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +                    A  +                    +          |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              2                                                            |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +                    +  +                               |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +                    +  +                               |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +                    +  +                               |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1  1     1                                                         |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +                    A  +                               |          |
SPINAL CORD                                 | +  +  +  +  +  +  +                    +  +                               |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +                    +  +                               |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  M  M  +  +  M  M                    +  +                               |          |
  INFLAMMATION                              |  1                                                                        |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,ALVEOLUS                      |                                                                          1|          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2  1     1     1  1  2     1  1  1        1  1  2  1     1            |          |
  LEUKOCYTOSIS                              |  3                                                                        |          |
  MINERALIZATION                            |                                         2                                 |          |
  THROMBUS                                  |                                      2                                    |          |
NOSE                                        | +  +  +  +  +  +  +                    +  +                               |          |
  MINERALIZATION,NASOLACRIMAL DUCT          |                                            3                              |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   17
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

TRACHEA                                     | +  +  +  +  +  +  +                    +  +                               |          |
  INFLAMMATION                              |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  A  +  A  +  +  A                    A  +                               |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +                    A  +                               |          |
LACRIMAL GLAND                              | +  +  +  +  +  M  M                    M  +                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1                                                            |          |
ZYMBAL'S GLAND                              | +  M  +  M  +  M  M                    +  +                               |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  A                    +  +                               |          |
  ACCUMULATION HYALINE DROPLET              |     2           2                                                         |          |
  CYST,RENAL TUBULE                         |     2  1                                                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1  1  1                          1                              |          |
  MINERALIZATION                            |                                         3                                 |          |
  NEPHROPATHY                               |                                         1                                 |          |
URINARY BLADDER                             | +  +  +  +  +  +  +                    +  +                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1  1     1                    1  1                              |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   18
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   |                                           +                               |  9       |
GALLBLADDER                                 |                                           M                               |  8       |
INTESTINE LARGE                             |                                           +                               |  9       |
INTESTINE LARGE,CECUM                       |                                           A                               |  6       |
INTESTINE LARGE,COLON                       |                                           +                               |  9       |
INTESTINE LARGE,RECTUM                      |                                           +                               |  8       |
INTESTINE SMALL                             |                                           +                               |  7       |
INTESTINE SMALL,DUODENUM                    |                                           +                               |  7       |
INTESTINE SMALL,ILEUM                       |                                           A                               |  6       |
INTESTINE SMALL,JEJUNUM                     |                                           A                               |  6       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |                                                  1                        |     2 1.0|
  BASOPHILIC FOCUS                          |                                                 X                         |     2    |
  CLEAR CELL FOCUS                          |                                                                           |     1    |
  EOSINOPHILIC FOCUS                        |                      X                                                    |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |  1                                   1                 1     1            |    13 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     3  1  2     1  1  1  1  1  1  1  1  1           1  1  1  1  1  1      |    35 1.2|
  NECROSIS                                  |  1  1     1     1  1  1  1  1     1  1  1     1     1  1  1  1  1  1      |    35 1.0|
  TENSION LIPOIDOSIS                        | X  X                 X                             X     X  X             |    13    |
  VACUOLIZATION CYTOPLASMIC                 |  1  1  1  1     2  2  1     1  2  2  2  1        2  2  2  2  2  2  2      |    36 1.6|
MESENTERY                                   |                            +                                              |  1       |
  NECROSIS,FAT                              |                             3                                             |     1 3.0|
PANCREAS                                    |                                           +                               |  8       |
  ATROPHY                                   |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     3 1.0|
SALIVARY GLANDS                             |                                  +        M                               | 10       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     6 1.0|
STOMACH                                     |                                           +                               | 10       |
STOMACH,FORESTOMACH                         |                                           +                               | 10       |
  HYPERKERATOSIS                            |                                                                           |     3 2.0|
  ULCER                                     |                                                                           |     1 2.0|
STOMACH,GLANDULAR                           |                                           +                               | 10       |
  MINERALIZATION                            |                                                                           |     1 2.0|
TONGUE                                      |                                           +                               |  9       |
  INFLAMMATION                              |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   19
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                |                                           M                               |  8       |
BLOOD VESSEL,AORTA                          |                                           M                               |  8       |
  MINERALIZATION                            |                                                                           |     1 4.0|
HEART                                       |                                           +                               | 10       |
  DEGENERATION                              |                                            2                              |     1 2.0|
  DILATATION                                |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               |                                           +                               |  9       |
ADRENAL GLAND,CORTEX                        |                                           +                               |  9       |
  HYPERPLASIA,SPINDLE CELL                  |                                                                           |     6 1.8|
ADRENAL GLAND,MEDULLA                       |                                           +                               |  9       |
ISLETS, PANCREATIC                          |                                           +                               |  8       |
PARATHYROID GLAND                           |                                           +                               |  9       |
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ANGIECTASIS                               |                                      1                                    |     1 1.0|
  DEGENERATION,CYSTIC,PARS DISTALIS         |                       1              1                                    |     2 1.0|
  HYPERPLASIA,PARS DISTALIS                 |     1  1                 1                                                |     6 1.0|
THYROID GLAND                               |                                           +                               |  9       |
  CYST,FOLLICLE                             |                                                                           |     1 2.0|
  DEGENERATION                              |                                            2                              |     1 2.0|
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |     1 4.0|
  ULTIMOBRANCHIAL CYST                      |                                                                           |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              |                                           +                               |  8       |
  ATROPHY                                   |                                            4                              |     6 3.5|
OVARY                                       | +                 +  +  +  +        +  +  +              +  +  +          | 29       |
  ATROPHY                                   |                                           X                               |     7    |
  CYST                                      | X                 X  X  X           X  X                    X  X          |    15    |
  CYST,PERIOVARIAN TISSUE                   |                                                          X                |     5    |
  HEMATOCYST                                |                            X                                              |     3    |
  MINERALIZATION                            |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   20
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

UTERUS                                      | +        +        +  +  +     +  +     +  A     +  +     +     +          | 26       |
  ATROPHY                                   |                                                                           |     5 3.4|
  DILATATION                                |                                         4           2                     |     2 3.0|
  FIBROSIS                                  |                                                                           |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2        4        4  4  3     2  2              3        2     2         |    16 2.6|
  INFLAMMATION                              |                                                                           |     1 4.0|
VAGINA                                      |                                           +                               |  9       |
  ATROPHY                                   |                                            3                              |     4 3.2|
  DYSPLASIA                                 |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 |                                           +                               | 10       |
  HYPERPLASIA                               |                                            4                              |     5 3.2|
LYMPH NODE                                  |       +     +                    +        +                               | 13       |
LYMPH NODE,MANDIBULAR                       |                                  +        +                               | 11       |
  HEMORRHAGE                                |                                                                           |     3 2.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       |             +                             +                               |  9       |
  ATROPHY                                   |                                                                           |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
SPLEEN                                      |             +                             +  +                            | 14       |
  ATROPHY                                   |                                                                           |     2 2.5|
  CONGESTION                                |                                                                           |     1 1.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     3 4.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     4 1.5|
THYMUS                                      |                                           M                               |  5       |
  ATROPHY,CORTEX                            |                                                                           |     3 3.6|
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                                                           |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               |                                           M                               |  6       |
  HYPERPLASIA                               |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   21
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

  LACTATION                                 |                                                                           |     1 2.0|
SKIN                                        |                                           +                               | 10       |
  EDEMA                                     |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        |                                           +                               | 10       |
BONE,FEMUR                                  |                                           +                               | 10       |
BONE,STERNUM                                |                                           +                               | 10       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                                                                           |     3 1.3|
SKELETAL MUSCLE                             |       +                                   +                               | 11       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       |                                           +                               | 10       |
BRAIN,CEREBELLUM                            |                                           +                               | 10       |
BRAIN,CEREBRUM                              |                                           +                               | 10       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                                                                           |     3 1.0|
PERIPHERAL NERVE                            |                                           +                               |  9       |
SPINAL CORD                                 |                                           +                               | 10       |
SPINAL CORD,THORACIC                        |                                           +                               | 10       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      |                                           M                               |  5       |
  INFLAMMATION                              |                                                                           |     1 1.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA,ALVEOLUS                      |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                            2                    1         |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1           1  1     1  2     1           1  1              1      |    24 1.1|
  LEUKOCYTOSIS                              |                                                                           |     1 3.0|
  MINERALIZATION                            |                                                                           |     1 2.0|
  THROMBUS                                  |                       1                                                   |     2 1.5|
NOSE                                        |                                           +                               | 10       |
  MINERALIZATION,NASOLACRIMAL DUCT          |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   22
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

TRACHEA                                     |                                           M                               |  9       |
  INFLAMMATION                              |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         |                                           A                               |  4       |
HARDERIAN GLAND                             |                                        +  +                               | 10       |
LACRIMAL GLAND                              |                                           M                               |  6       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     3 1.0|
ZYMBAL'S GLAND                              |                                           +                               |  6       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      |             +                             +                               | 10       |
  ACCUMULATION HYALINE DROPLET              |                                            3                              |     3 2.3|
  CYST,RENAL TUBULE                         |                                                                           |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     5 1.0|
  MINERALIZATION                            |                                                                           |     1 3.0|
  NEPHROPATHY                               |                                                                           |     1 1.0|
URINARY BLADDER                             |                                           +                               | 10       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     6 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   23
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | M  +  +  +                                                                |          |
GALLBLADDER                                 | +  M  +  +                                                                |          |
INTESTINE LARGE                             | +  +  A  +                                                                |          |
INTESTINE LARGE,CECUM                       | +  +  A  +                                                                |          |
INTESTINE LARGE,COLON                       | +  +  A  +                                                                |          |
INTESTINE LARGE,RECTUM                      | +  +  A  +                                                                |          |
INTESTINE SMALL                             | +  +  A  +                                                                |          |
INTESTINE SMALL,DUODENUM                    | +  +  A  +                                                                |          |
INTESTINE SMALL,ILEUM                       | +  +  A  +                                                                |          |
INTESTINE SMALL,JEJUNUM                     | +  +  A  +                                                                |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                      X                                                    |          |
  CYST,BILE DUCT                            |                                                                           |          |
  DEGENERATION                              |     3                                                                     |          |
  EOSINOPHILIC FOCUS                        |                   X                          X     X                      |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  1  1           1                 1        1                 1     1      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1  1     1  1  3  3     1  2  2     1  1  2  1  1  2  1  1  1  2|          |
  NECROSIS                                  |  1              2  1           1     1     1  1  1  1  1  1  1  1     1  1|          |
  NECROSIS,COAGULATIVE                      |     3  1                                                                  |          |
  REGENERATION                              |     3                                                                     |          |
  TENSION LIPOIDOSIS                        |                         X  X     X     X        X  X  X                 X |          |
  VACUOLIZATION CYTOPLASMIC                 |  1        3     2           1  2                 1     2  2  2  2     1  2|          |
MESENTERY                                   |                                                                           |          |
  NECROSIS,FAT                              |                                                                           |          |
PANCREAS                                    | +  +  +  +                                                                |          |
  FOCAL CELLULAR CHANGE                     |  1        1                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                                  |          |
  POLYARTERITIS                             |  4                                                                        |          |
SALIVARY GLANDS                             | +  +  +  +                                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1                                                                  |          |
  POLYARTERITIS                             |  2                                                                        |          |
STOMACH                                     | +  +  A  +                                                                |          |
STOMACH,FORESTOMACH                         | +  +  A  +                                                                |          |
STOMACH,GLANDULAR                           | +  +  A  +                                                                |          |
  CYST                                      |     2                                                                     |          |
TONGUE                                      | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   24
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  POLYARTERITIS                             |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +                                                                |          |
BLOOD VESSEL,AORTA                          | +  +  +  +                                                                |          |
HEART                                       | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +                                                                |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +                                                                |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  2                                                               |          |
ADRENAL GLAND,MEDULLA                       | M  +  +  +                                                                |          |
ISLETS, PANCREATIC                          | +  +  +  +                                                                |          |
  HYPERPLASIA                               |                                                                           |          |
PARATHYROID GLAND                           | M  M  +  +                                                                |          |
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ANGIECTASIS                               |                                                                           |          |
  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                                           |          |
THYROID GLAND                               | +  +  +  +                                                                |          |
  POLYARTERITIS                             |  4                                                                        |          |
  ULTIMOBRANCHIAL CYST                      |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  M  M                                                        +       |          |
  ATROPHY                                   |  4  3                                                              3      |          |
OVARY                                       | M  +  +  +        +              +              +     +  +     +     +  + |          |
  ATROPHY                                   |                                                                           |          |
  CYST                                      |    X     X        X              X              X        X              X |          |
  CYST,PERIOVARIAN TISSUE                   |                                                       X        X          |          |
  HEMATOCYST                                |       X                                                                   |          |
  HYPERPLASIA,ADENOMATOUS                   |        3                                                                  |          |
UTERUS                                      | +  +  +  +  +  +        +  +        +     +     +     +     +     +     + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   25
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  ANGIECTASIS                               |                                            4                              |          |
  ATROPHY                                   |  2  3                                                                     |          |
  DILATATION                                |                                                                    4      |          |
  FIBROSIS                                  |           2                                                               |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |           2  3  2        3  3        2     3     2     2     2           3|          |
VAGINA                                      | +  +  +  +                                                                |          |
  ATROPHY                                   |     3                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +                                                                |          |
LYMPH NODE                                  | +  +  +  +           +           +                                        |          |
  HYPERPLASIA,LYMPHOID,INGUINAL             |  3                                                                        |          |
  HYPERPLASIA,LYMPHOID,THORACIC             |  3                                                                        |          |
LYMPH NODE,MANDIBULAR                       | +  +  M  +           +                                                    |          |
  HYPERPLASIA,LYMPHOID                      |  3                                                                        |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +                       +                                        |          |
  HEMORRHAGE                                |        2                                                                  |          |
  HYPERPLASIA,LYMPHOID                      |  3  2                                                                     |          |
  POLYARTERITIS,ARTERY                      |  4                                                                        |          |
SPLEEN                                      | +  +  +  +           +           +        +     +     +  +           +    |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  2  3  3                                                              3   |          |
  HYPERPLASIA,LYMPHOID                      |                                            2     1                        |          |
THYMUS                                      | +  +  +  +                       +                                        |          |
  ATROPHY,CORTEX                            |  4  4  4                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  +  +  +                                                                |          |
SKIN                                        | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +                                                                |          |
BONE,FEMUR                                  | +  +  +  +                                                                |          |
  POLYARTERITIS                             |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   26
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE,STERNUM                                | +  +  +  +                                                                |          |
SKELETAL MUSCLE                             | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +                                                                |          |
BRAIN,CEREBELLUM                            | +  +  +  +                                                                |          |
BRAIN,CEREBRUM                              | +  +  +  +                                                                |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1                                                                  |          |
  POLYARTERITIS                             |  4                                                                        |          |
PERIPHERAL NERVE                            | +  +  +  +                                                                |          |
SPINAL CORD                                 | +  +  +  +                                                                |          |
SPINAL CORD,THORACIC                        | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  M  M  +                                                                |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMORRHAGE                                |        3                                                                  |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                         2                                 |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1  1  1  1  1  1  1  1  1  1  1  1  1        2     1  1  1|          |
  THROMBUS                                  |                             1                                             |          |
NOSE                                        | +  +  +  +                                                                |          |
TRACHEA                                     | M  +  +  +                                                                |          |
  ECTASIA,GLANDS                            |     2                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +                                                                |          |
HARDERIAN GLAND                             | +  +  +  +                                                                |          |
  INFLAMMATION                              |                                                                           |          |
LACRIMAL GLAND                              | +  M  +  +                                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1                                                                  |          |
ZYMBAL'S GLAND                              | M  M  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   27
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | +  +  +  +                                                                |          |
  ACCUMULATION HYALINE DROPLET              |        2                                                                  |          |
  CYST,RENAL TUBULE                         |  2     2  2                                                               |          |
  GLOMERULOSCLEROSIS                        |  3                                                                        |          |
  HYDRONEPHROSIS                            |     1                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  2  1                                                               |          |
  PIGMENTATION,RENAL TUBULE                 |     3                                                                     |          |
  POLYARTERITIS                             |  3                                                                        |          |
URINARY BLADDER                             | +  +  +  +                                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1  1  1                                                               |          |
  POLYARTERITIS                             |  4                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   28
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   |                      +                                                    |  4       |
GALLBLADDER                                 |                      +                                                    |  4       |
INTESTINE LARGE                             |                      A                                                    |  3       |
INTESTINE LARGE,CECUM                       |                      A                                                    |  3       |
INTESTINE LARGE,COLON                       |                      A                                                    |  3       |
INTESTINE LARGE,RECTUM                      |                      A                                                    |  3       |
INTESTINE SMALL                             |                   +  +                    +                               |  6       |
INTESTINE SMALL,DUODENUM                    |                      +                                                    |  4       |
INTESTINE SMALL,ILEUM                       |                      A                                                    |  3       |
INTESTINE SMALL,JEJUNUM                     |                      +                    +                               |  5       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                                                                           |     1    |
  CYST,BILE DUCT                            |                                                           2               |     1 2.0|
  DEGENERATION                              |                                                                           |     1 3.0|
  EOSINOPHILIC FOCUS                        |                                                       X                   |     4    |
  HEMATOPOIETIC CELL PROLIFERATION          |  1        1  1     1     1              1                 1     1  1      |    16 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1     1  1  2  1  2        1  1  1  2  2  1  1     1  1  1      |    40 1.3|
  NECROSIS                                  |        1  1  1  1  1           1  1  1  1     1  1  1  1  1  1     1      |    31 1.0|
  NECROSIS,COAGULATIVE                      |                                                                           |     2 2.0|
  REGENERATION                              |                                                                           |     1 3.0|
  TENSION LIPOIDOSIS                        |       X  X           X  X  X                       X           X  X       |    16    |
  VACUOLIZATION CYTOPLASMIC                 |        1     2  2  2  3  2  3  2  2  2     2  2  3  3  2  2     1  2      |    30 1.9|
MESENTERY                                   |                      +                                                    |  1       |
  NECROSIS,FAT                              |                       4                                                   |     1 4.0|
PANCREAS                                    |                      +                                                    |  5       |
  FOCAL CELLULAR CHANGE                     |                                                                           |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     2 1.0|
  POLYARTERITIS                             |                                                                           |     1 4.0|
SALIVARY GLANDS                             |                      +                                                    |  5       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     4 1.2|
  POLYARTERITIS                             |                                                                           |     1 2.0|
STOMACH                                     |                      +                                                    |  4       |
STOMACH,FORESTOMACH                         |                      +                                                    |  4       |
STOMACH,GLANDULAR                           |                      +                                                    |  4       |
  CYST                                      |                                                                           |     1 2.0|
TONGUE                                      |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   29
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  POLYARTERITIS                             |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                |                      +                                                    |  5       |
BLOOD VESSEL,AORTA                          |                      +                                                    |  5       |
HEART                                       |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               |                      +                                                    |  5       |
ADRENAL GLAND,CORTEX                        |                      +                                                    |  5       |
  HYPERPLASIA,SPINDLE CELL                  |                                                                           |     2 2.0|
ADRENAL GLAND,MEDULLA                       |                      M                                                    |  3       |
ISLETS, PANCREATIC                          |                      +                                                    |  5       |
  HYPERPLASIA                               |                       1                                                   |     1 1.0|
PARATHYROID GLAND                           |                      +                                                    |  3       |
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ANGIECTASIS                               |                                1                             1            |     2 1.0|
  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                        2                  |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |                 1        1     1                             1            |     4 1.0|
THYROID GLAND                               |                      +                                                    |  5       |
  POLYARTERITIS                             |                                                                           |     1 4.0|
  ULTIMOBRANCHIAL CYST                      |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              |                      +                                                    |  4       |
  ATROPHY                                   |                       4                                                   |     4 3.5|
OVARY                                       |       +     +  +     +        +     +     +  +     +  +                   | 21       |
  ATROPHY                                   |                      X                                                    |     1    |
  CYST                                      |                X              X     X     X  X     X                      |    13    |
  CYST,PERIOVARIAN TISSUE                   |             X                                         X                   |     4    |
  HEMATOCYST                                |       X                                                                   |     2    |
  HYPERPLASIA,ADENOMATOUS                   |                                                                           |     1 3.0|
UTERUS                                      | +     +  +  +        +  +           +  +        +  +  +  +     +  +       | 29       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   30
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  ANGIECTASIS                               |                                                                           |     1 4.0|
  ATROPHY                                   |                       4                                                   |     3 3.0|
  DILATATION                                |                                         4                                 |     2 4.0|
  FIBROSIS                                  |                                                                           |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2     2  2  4           2           2           3  3  3  2     2  4      |    23 2.5|
VAGINA                                      |                      +                                                    |  5       |
  ATROPHY                                   |                       3                                                   |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 |                      +                                                    |  5       |
LYMPH NODE                                  |                   +  +                                                    |  8       |
  HYPERPLASIA,LYMPHOID,INGUINAL             |                                                                           |     1 3.0|
  HYPERPLASIA,LYMPHOID,THORACIC             |                                                                           |     1 3.0|
LYMPH NODE,MANDIBULAR                       |                      +                                                    |  5       |
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       |                   +  +                                                    |  7       |
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     2 2.5|
  POLYARTERITIS,ARTERY                      |                                                                           |     1 4.0|
SPLEEN                                      |    +  +        +  +  +                    +  +                    +       | 19       |
  HEMATOPOIETIC CELL PROLIFERATION          |                                            1                              |     5 2.4|
  HYPERPLASIA,LYMPHOID                      |     3           2                                                  1      |     5 1.8|
THYMUS                                      |                      M                                                    |  5       |
  ATROPHY,CORTEX                            |                                                                           |     3 4.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               |                      +     +                                              |  5       |
SKIN                                        |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        |                      +                                                    |  5       |
BONE,FEMUR                                  |                      +                                                    |  5       |
  POLYARTERITIS                             |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   31
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE,STERNUM                                |                      +                                                    |  5       |
SKELETAL MUSCLE                             |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       |                      +                                                    |  5       |
BRAIN,CEREBELLUM                            |                      +                                                    |  5       |
BRAIN,CEREBRUM                              |                      +                                                    |  5       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                                                                           |     1 1.0|
  POLYARTERITIS                             |                                                                           |     1 4.0|
PERIPHERAL NERVE                            |                      +                                                    |  5       |
SPINAL CORD                                 |                      +                                                    |  5       |
SPINAL CORD,THORACIC                        |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      |                      M                                                    |  1       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HEMORRHAGE                                |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |              2                                                            |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  1  1  1     1  1           1              1           2     1      |    29 1.1|
  THROMBUS                                  |                                                                           |     1 1.0|
NOSE                                        |                      +                                                    |  5       |
TRACHEA                                     |                      +                                                    |  4       |
  ECTASIA,GLANDS                            |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         |                      +                                                    |  5       |
HARDERIAN GLAND                             |             +        +                                                    |  6       |
  INFLAMMATION                              |              2                                                            |     1 2.0|
LACRIMAL GLAND                              |                      +                                                    |  4       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     3 1.3|
ZYMBAL'S GLAND                              |                      +                                                    |  3       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   32
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      |                      +                                                    |  5       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     1 2.0|
  CYST,RENAL TUBULE                         |                       1                                                   |     4 1.7|
  GLOMERULOSCLEROSIS                        |                                                                           |     1 3.0|
  HYDRONEPHROSIS                            |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     4 1.2|
  PIGMENTATION,RENAL TUBULE                 |                                                                           |     1 3.0|
  POLYARTERITIS                             |                                                                           |     1 3.0|
URINARY BLADDER                             |                      +                                                    |  5       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     5 1.2|
  POLYARTERITIS                             |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   33
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:14.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |        3                                                                  |          |
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2           1                  |          |
INTESTINE LARGE                             | +  +  A  +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  A  +  A  +  A  +  +  +  +  A  M  A  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |           2                                                               |          |
INTESTINE LARGE,COLON                       | +  +  A  +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE SMALL                             | +  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
INTESTINE SMALL,ILEUM                       | A  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
  INFLAMMATION                              |                                                                           |          |
INTESTINE SMALL,JEJUNUM                     | A  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  CONGESTION                                |  1                                                                        |          |
  EOSINOPHILIC FOCUS                        |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                 1     1     1                                             |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1     1  1  1        1  1  1  3  1  1  1  1     1  1  1  1|          |
  INFLAMMATION                              |                                                                           |          |
  MINERALIZATION                            |                                                                           |          |
  NECROSIS                                  |                             1     1  1        2  1  1  1     1  1     1  1|          |
  TENSION LIPOIDOSIS                        |                         X  X        X              X  X     X             |          |
  VACUOLIZATION CYTOPLASMIC                 |           2           1  1  1        1                 1           1  2  1|          |
MESENTERY                                   |                                                                           |          |
  NECROSIS,FAT                              |                                                                           |          |
PANCREAS                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTASIA,DUCT                              |                                                        1                  |          |
  FOCAL CELLULAR CHANGE                     |  1                                                        2               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1  1  1              2  1  1           1  1     1  1|          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   34
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:14.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |                       2                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1  1        1  1  1  1  1  1  2  2  2  1  2  1  2  1  2  1  2|          |
STOMACH                                     | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  A  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |  2                 2                                                      |          |
STOMACH,GLANDULAR                           | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                                     1                     |          |
  MINERALIZATION                            |                                                                           |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |  2                                                                        |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                                           |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTOPIC TISSUE                            |                                                                   X       |          |
  HYPERPLASIA                               |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  3  2  2     2  2  2  1  2  2     3  2  2  2  2  2  1  2  3  1  2|          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                           1               |          |
  VACUOLIZATION CYTOPLASMIC                 |                       1                                                   |          |
ISLETS, PANCREATIC                          | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                          1                                                |          |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M |          |
  CYST                                      |                                                                           |          |
  ECTOPIC THYMUS                            |                                              X        X                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   35
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:14.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
PITUITARY GLAND                             | M  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  HEMORRHAGE                                |     2                                                                     |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                           3           2  2|          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CRYSTALS                                  |                                                                           |          |
  DEGENERATION                              |                                               2                           |          |
  ECTOPIC THYMUS                            |                                                                           |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                           2              2|          |
  ULTIMOBRANCHIAL CYST                      |                 2                    2                    3               |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           3  1  3  2  4  4  3  3  3  3     3  3  3     3  3  3  3     3  3|          |
OVARY                                       | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   | X           X  X     X  X     X  X  X  X        X  X  X  X     X  X  X  X |          |
  CYST                                      |                            X           X     X              X     X       |          |
  CYST,PERIOVARIAN TISSUE                   |                               X     X        X  X  X     X  X        X  X |          |
  HEMATOCYST                                |                                           X     X                         |          |
  HYPERPLASIA,ADENOMATOUS                   |                                                                           |          |
  HYPERPLASIA,TUBULAR                       |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                  3                        |          |
  MINERALIZATION                            |                                                                           |          |
  POLYARTERITIS                             |                                                                           |          |
UTERUS                                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |  3                       3                                                |          |
  FIBROSIS                                  |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |           3  2  1     2     3  4  2  4     2     3  3  2  2     2  4     3|          |
  HYPERTROPHY,MYOMETRIUM                    |                                                              2            |          |
  METAPLASIA,SQUAMOUS                       |                                                                           |          |
  PROLAPSE                                  |                                                                   X       |          |
VAGINA                                      | +  +  +  M  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                          3     2                                          |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   36
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:14.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  DYSPLASIA                                 |                                            2                       2      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |           4        4                    3           3                     |          |
LYMPH NODE                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION,INGUINAL |                                                                           |          |
  HEMORRHAGE,INGUINAL                       |                                                                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC,INGUINAL|                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                                                              2            |          |
  HYPERPLASIA,PLASMA CELL                   |              3                                                            |          |
LYMPH NODE,MESENTERIC                       | A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  + |          |
  ATROPHY                                   |     4                                                                     |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |          |
SPLEEN                                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                           |          |
  CONGESTION                                |  3           1                                                        1   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |           3  3                          3                             3   |          |
  HYPERPLASIA,LYMPHOID                      |                                            2     3           1        1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFILTRATION CELLULAR,PLASMA CELL         |              2                                                            |          |
  INFLAMMATION                              |                                                                           |          |
THYMUS                                      | M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,CORTEX                            |        4  3  2  4           3     2  4     2  3  2  2  3  3  3  4  2     2|          |
  CYST                                      |                                                                           |          |
  ECTOPIC PARATHYROID GLAND                 |                            X                                              |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                             2     2        3  2        2     2     2     2|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   37
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:15.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  A  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                          2           3     3  2                           |          |
  LACTATION                                 |                                                                           |          |
SKIN                                        | +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,CARTILAGE                    |                                                                           |          |
  FIBROUS OSTEODYSTROPHY                    |                          3                                2               |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                 1           4        1        2  3  3  3  3  3  3  2  2   |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |              1  1  1        1           1        1     1  2  2            |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
SPINAL CORD                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEVELOPMENTAL MALFORMATION                |                                                                          2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            1                              |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                        3                  |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   38
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:15.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1           2        1  1     1        2  1  1  1     1  1  1     1  2|          |
  INFLAMMATION                              |  3                          2                                             |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYTOPLASMIC ALTERATION,RESPIRATORY EPITHEL|                                                                           |          |
    IUM                                     |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC,GLANDS  |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC,NASOLACR|                                                                           |          |
    IMAL DUCT                               |                                                                           |          |
TRACHEA                                     | +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTASIA,GLANDS                            |                                               2                           |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  A  +  A  A  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                          3                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1                             1                 1        1|          |
LACRIMAL GLAND                              | +  +  A  +  +  +  M  M  +  M  +  +  +  M  +  M  +  +  +  +  +  +  M  +  + |          |
  ATROPHY                                   |     2                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1                          2     2  2  1  1              1|          |
ZYMBAL'S GLAND                              | M  +  M  M  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET              |           3                    1                                          |          |
  AMYLOID DEPOSITION,GLOMERULUS             |     4                                                                     |          |
  CYST,RENAL TUBULE                         |     3     1     1        1  1        1        1           1           1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1  3        1  1  1  2  1     2  1  2  1  1  1  1  2  1  1  2|          |
  NECROSIS,RENAL TUBULE                     |                                                                           |          |
  PIGMENTATION,RENAL TUBULE                 |                                                                       2   |          |
URINARY BLADDER                             | A  +  M  M  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1        1  2     1  1     1  1  1  1  1  2  1     1  1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   39
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERKERATOSIS                            |                                                                           |     1 3.0|
GALLBLADDER                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                    1              1                                       |     4 1.2|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 41       |
  HYPERPLASIA,LYMPHOID                      |                             2        2                             2      |     4 2.0|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 43       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,LYMPHOID                      |                                2                                          |     1 2.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 42       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 42       |
  INFLAMMATION                              |                                                                 2         |     1 2.0|
INTESTINE SMALL,ILEUM                       | +  M  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 39       |
  HYPERPLASIA,LYMPHOID                      |                       2                                                   |     1 2.0|
  INFLAMMATION                              |                                                                 2         |     1 2.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 41       |
  INFLAMMATION                              |                                                                 2         |     1 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          | X                          X                                              |     2    |
  CONGESTION                                |                                                                           |     1 1.0|
  EOSINOPHILIC FOCUS                        |                                           X                               |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |        1                                                                  |     4 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  1  1     1  3  1     3     1  1  1     1  2  1  1  1      |    36 1.1|
  INFLAMMATION                              |                                                                 3         |     1 3.0|
  MINERALIZATION                            |                                                                 1         |     1 1.0|
  NECROSIS                                  |  1  2  1  1  1  1  1  1  1  1  1  1  2     1  1  1  1  1  1  1     1      |    32 1.0|
  TENSION LIPOIDOSIS                        | X                 X     X  X     X        X           X  X  X  X          |    16    |
  VACUOLIZATION CYTOPLASMIC                 |     1        2  1           1     1  1     1  1  2  2  1  1  1     2      |    23 1.2|
MESENTERY                                   |                +                                                          |  1       |
  NECROSIS,FAT                              |                 4                                                         |     1 4.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +       | 46       |
  ECTASIA,DUCT                              |                                                                           |     1 1.0|
  FOCAL CELLULAR CHANGE                     |                                                                           |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2           1     1  1           2           1  1  1     1            |    19 1.1|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   40
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |                                                           1               |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  2  1  1  2  1  2  1  1  1  1  1  1  1  1  2  1     2     1      |    41 1.2|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  HYPERKERATOSIS                            |                                                                           |     2 2.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  CYST                                      |                                                     1     1               |     3 1.0|
  MINERALIZATION                            |                    1                 1                                    |     2 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +       | 45       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +       | 45       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1                       1                        |     2 1.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
  POLYARTERITIS                             |                 2                                                         |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ACCESSORY ADRENAL CORTICAL NODULE         |                X                                                          |     1    |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ECTOPIC TISSUE                            |                                                    X                      |     2    |
  HYPERPLASIA                               |                 1                                                         |     1 1.0|
  HYPERPLASIA,SPINDLE CELL                  |  2  2  2  2  2  1  2  2  2  1  1  1  2  3  2  3  2  2  2  2  1  3  1      |    44 1.9|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA                               |                                                                 2         |     2 1.5|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 1.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA                               |                                                                           |     1 1.0|
PARATHYROID GLAND                           | +  +  +  +  +  M  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M       | 40       |
  CYST                                      |     2                                                                     |     1 2.0|
  ECTOPIC THYMUS                            |                                                                           |     2    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         3                                 |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   41
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  VACUOLIZATION CYTOPLASMIC                 |                                                                 2         |     1 2.0|
PITUITARY GLAND                             | +  M  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 41       |
  ANGIECTASIS                               |                                                  2                        |     1 2.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |  3              2        2  2     2                 2                     |     9 2.2|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CRYSTALS                                  |                          1                                                |     1 1.0|
  DEGENERATION                              |                                                                           |     1 2.0|
  ECTOPIC THYMUS                            |    X                                                                      |     1    |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |     2 2.0|
  ULTIMOBRANCHIAL CYST                      |        2     2     2        2     2        2           4                  |    10 2.3|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +       | 43       |
  ATROPHY                                   |  3  3     4  3  3  4  4  3  3  2     4  4     3  3  3  3  3  3     3      |    38 3.0|
OVARY                                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   | X        X  X  X  X     X  X  X  X  X     X  X     X  X  X  X  X  X       |    35    |
  CYST                                      | X     X     X                    X     X  X        X        X  X          |    14    |
  CYST,PERIOVARIAN TISSUE                   |          X           X  X  X  X                 X                         |    15    |
  HEMATOCYST                                |                                                 X                         |     3    |
  HYPERPLASIA,ADENOMATOUS                   |                                   4                                       |     1 4.0|
  HYPERPLASIA,TUBULAR                       |                       1                                      3            |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                           2               |     2 2.5|
  MINERALIZATION                            |                                      1                                    |     1 1.0|
  POLYARTERITIS                             |                 2                                                         |     1 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ANGIECTASIS                               |  3                                                                        |     1 3.0|
  ATROPHY                                   |                                                                           |     2 3.0|
  FIBROSIS                                  |                                                  2                        |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  4  3  3  2  2  2  2  2  2  2  2     2     3  2  2  2  2  2  2  2  2      |    37 2.4|
  HYPERTROPHY,MYOMETRIUM                    |                                                  3                        |     2 2.5|
  METAPLASIA,SQUAMOUS                       |                                                  2                        |     1 2.0|
  PROLAPSE                                  |                                                                           |     1    |
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  ATROPHY                                   |                                         4                                 |     3 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   42
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  DYSPLASIA                                 |                                                                           |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                        1                  |     2 1.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                          2              4                                 |     6 3.3|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HEMATOPOIETIC CELL PROLIFERATION          |                                         4                                 |     1 4.0|
  HEMATOPOIETIC CELL PROLIFERATION,INGUINAL |                                         4                                 |     1 4.0|
  HEMORRHAGE,INGUINAL                       |                                         2                                 |     1 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC,INGUINAL|                                         3                                 |     1 3.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HEMATOPOIETIC CELL PROLIFERATION          |                                         4                                 |     1 4.0|
  HYPERPLASIA,LYMPHOID                      |  2  2     2     2                    3     2  3        3                  |     9 2.3|
  HYPERPLASIA,PLASMA CELL                   |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 44       |
  ATROPHY                                   |                                                                           |     1 4.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                         3                                 |     1 3.0|
  HEMORRHAGE                                |              3                          4                                 |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |                 2                                      3                  |     2 2.5|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                         4                                 |     1 4.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                         2                                 |     1 2.0|
  CONGESTION                                |                                                                           |     3 1.6|
  HEMATOPOIETIC CELL PROLIFERATION          |  3     3        3                       4        2                        |     9 3.0|
  HYPERPLASIA,LYMPHOID                      |     3           1           1     1  1        1     4                     |    11 1.7|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1                                                               |     1 1.0|
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |     1 2.0|
  INFLAMMATION                              |                                                                 4         |     1 4.0|
THYMUS                                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ATROPHY,CORTEX                            |  3        3  4  3  2  2     3  2  3  3  2  3  3  3  4        3     3      |    34 2.8|
  CYST                                      |                                                           2               |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |  2        2     2  1  2              2           2     3  2               |    17 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   43
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERPLASIA                               |     2     1                                                        1      |     7 2.0|
  LACTATION                                 |                          2                                                |     1 2.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  DEGENERATION,CARTILAGE                    |                       2                                                   |     1 2.0|
  FIBROUS OSTEODYSTROPHY                    |           2              3     2  1        1        4        2     1      |    10 2.1|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |     2  2  2  1  3  4  1  2  2  2  3  1     2  2  3  3  2  3  4  3  2      |    33 2.3|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1     1     1  1  1  1           1     1  1           1  1  1     1      |    22 1.0|
PERIPHERAL NERVE                            | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  DEVELOPMENTAL MALFORMATION                |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  INFLAMMATION                              |                                                              2            |     1 2.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                        4                  |     1 4.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   44
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1           2  1  1           1  2  2  2  1  1  1  2  2        1      |    29 1.3|
  INFLAMMATION                              |                                                                           |     2 2.5|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CYTOPLASMIC ALTERATION,RESPIRATORY EPITHEL|                       1                                                   |     1 1.0|
    IUM                                     |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC,GLANDS  |                                                           1               |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC,NASOLACR|                                                           2               |     1 2.0|
    IMAL DUCT                               |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ECTASIA,GLANDS                            |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 40       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1           1  1     1                                1  1  1      |    12 1.0|
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 40       |
  ATROPHY                                   |                             2        2                                    |     3 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1  1     1     1  2  1     1           1  1  1  1           1      |    20 1.2|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +       | 40       |
  INFLAMMATION                              |                                      2                                    |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     2 2.0|
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |     1 4.0|
  CYST,RENAL TUBULE                         |                    1           1  1        1  1  1     1           1      |    17 1.1|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  1     1  2  1  1  1  2  1  1  2  1  1  2  2  2  1           2      |    38 1.3|
  NECROSIS,RENAL TUBULE                     |                                                     1                     |     1 1.0|
  PIGMENTATION,RENAL TUBULE                 |                                                                           |     1 2.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  1  1  1     1  1  1  1     1  1  1  1  1  2  1     1      |    35 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   45
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:32.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|                                                      U  V   I|
CONTRL F3MTHR 05     5                      | 2| 3| 4| 5| 6| 7| 8| 9|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +                                                    |  8       |
  INFLAMMATION,MEDIASTINUM                  |                       4                                                   |     1 4.0|
GALLBLADDER                                 | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +                                                    |  8       |
LIVER                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1                                                               |     1 1.0|
  NECROSIS                                  |     1  1     1  1  1  1                                                   |     6 1.0|
PANCREAS                                    | +  +  +  +  +  +  +  +                                                    |  8       |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1           1  1  1                                                   |     5 1.0|
STOMACH                                     | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +                                                    |  8       |
TONGUE                                      | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  M  +                                                    |  7       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  M  +                                                    |  7       |
HEART                                       | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,SPINDLE CELL                  |        1  1     1     1                                                   |     4 1.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +                                                    |  8       |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +                                                    |  8       |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  M                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   46
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:32.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|                                                      U  V   I|
CONTRL F3MTHR 05     5                      | 2| 3| 4| 5| 6| 7| 8| 9|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

PITUITARY GLAND                             | +  +  +  +  +  +  +  +                                                    |  8       |
THYROID GLAND                               | +  +  +  +  +  +  +  M                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  M  +  +  +  +  +  +                                                    |  7       |
OVARY                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  CONGESTION                                |                    1                                                      |     1 1.0|
UTERUS                                      | +  +  +  +  +  +  +  +                                                    |  8       |
VAGINA                                      | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA                               |                       2                                                   |     1 2.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +                                                    |  8       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,LYMPHOID                      |     2                                                                     |     1 2.0|
LYMPH NODE,MESENTERIC                       | +  M  +  +  +  +  +  +                                                    |  7       |
  HYPERPLASIA,LYMPHOID                      |  3                                                                        |     1 3.0|
SPLEEN                                      | +  +  +  +  +  +  +  +                                                    |  8       |
THYMUS                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  CYST                                      |     1                                                                     |     1 1.0|
  INFLAMMATION,MEDIASTINUM                  |                    1                                                      |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
SKIN                                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,STERNUM                                | +  +  +  +  +  +  +  +                                                    |  8       |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   47
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:32.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|                                                      U  V   I|
CONTRL F3MTHR 05     5                      | 2| 3| 4| 5| 6| 7| 8| 9|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +                                                    |  8       |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M  M  M  M  M  +                                                    |  3       |
LUNG                                        | +  +  +  +  +  +  +  +                                                    |  8       |
  CONGESTION                                |     2                                                                     |     1 2.0|
  HEMORRHAGE                                |           1                                                               |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1                                                               |     1 1.0|
NOSE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
TRACHEA                                     | +  +  +  +  +  +  +  M                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +                                                    |  8       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +                                                    |  8       |
LACRIMAL GLAND                              | +  +  +  +  +  M  +  +                                                    |  7       |
ZYMBAL'S GLAND                              | +  +  +  +  +  M  +  +                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +                                                    |  8       |
URINARY BLADDER                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1                                                            |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   48
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:34.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 2| 2| 2| 2| 2| 2| 2| 2|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|                                                      U  V   I|
CONTRL F6MTHR 06     6                      | 1| 2| 3| 4| 5| 6| 7| 8|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | M  +  +  +  +  +  +  +                                                    |  7       |
GALLBLADDER                                 | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +                                                    |  8       |
LIVER                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1     1                                                         |     3 1.0|
  NECROSIS                                  |  1     2  1  1     1                                                      |     5 1.2|
  TENSION LIPOIDOSIS                        |                      X                                                    |     1    |
  VACUOLIZATION CYTOPLASMIC                 |  1        1  1  1     1                                                   |     5 1.0|
PANCREAS                                    | +  +  +  +  +  +  +  +                                                    |  8       |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1     1        1                                                   |     4 1.0|
STOMACH                                     | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +                                                    |  8       |
  INFLAMMATION                              |  1                                                                        |     1 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                    1                                                      |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  M  +  +  +                                                    |  7       |
BLOOD VESSEL,AORTA                          | +  +  +  +  M  +  +  +                                                    |  7       |
HEART                                       | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,SPINDLE CELL                  |  2  1        1     1                                                      |     4 1.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   49
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:35.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 2| 2| 2| 2| 2| 2| 2| 2|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|                                                      U  V   I|
CONTRL F6MTHR 06     6                      | 1| 2| 3| 4| 5| 6| 7| 8|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +                                                    |  8       |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +                                                    |  8       |
PARATHYROID GLAND                           | +  M  M  M  +  M  +  +                                                    |  4       |
  ECTOPIC THYMUS                            |             X                                                             |     1    |
PITUITARY GLAND                             | M  +  M  +  M  +  M  M                                                    |  3       |
THYROID GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +                                                    |  8       |
OVARY                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  CYST                                      |       X                                                                   |     1    |
  HEMATOCYST                                |       X                                                                   |     1    |
UTERUS                                      | +  +  +  +  +  +  +  +                                                    |  8       |
VAGINA                                      | +  +  +  +  M  +  +  +                                                    |  7       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1                                                         |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA                               |              3                                                            |     1 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +                                                    |  8       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +                                                    |  8       |
  FIBROSIS                                  |              3                                                            |     1 3.0|
  HYPERPLASIA,LYMPHOID                      |        2              2                                                   |     2 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +                                                    |  8       |
SPLEEN                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  CONGESTION                                |     2                                                                     |     1 2.0|
  HEMATOPOIETIC CELL PROLIFERATION          |              3                                                            |     1 3.0|
  HYPERPLASIA,LYMPHOID                      |     2                                                                     |     1 2.0|
THYMUS                                      | +  +  +  +  M  +  +  +                                                    |  7       |
  ATROPHY,CORTEX                            |        2              2                                                   |     2 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   50
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:35.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 2| 2| 2| 2| 2| 2| 2| 2|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|                                                      U  V   I|
CONTRL F6MTHR 06     6                      | 1| 2| 3| 4| 5| 6| 7| 8|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
SKIN                                        | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA                               |           2                                                               |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,STERNUM                                | +  +  +  +  +  +  +  +                                                    |  8       |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +                                                    |  8       |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  M  +  M  M  +  M  M                                                    |  3       |
LUNG                                        | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  1  1                                                      |     5 1.0|
NOSE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
TRACHEA                                     | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +                                                    |  8       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +                                                    |  8       |
LACRIMAL GLAND                              | +  +  M  +  M  +  +  +                                                    |  6       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1     1                                                   |     2 1.0|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  M  +                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   51
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:35.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 2| 2| 2| 2| 2| 2| 2| 2|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|                                                      U  V   I|
CONTRL F6MTHR 06     6                      | 1| 2| 3| 4| 5| 6| 7| 8|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1        1                                                   |     2 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1  1                                                      |     2 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   52
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:37.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 3| 3| 3| 3| 3| 3| 3|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 4| 4| 4| 4| 4| 4| 4| 4|                                                      U  V   I|
CONTRL F12MTHR07     7                      | 0| 1| 2| 3| 4| 5| 6| 7|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERKERATOSIS                            |        2                                                                  |     1 2.0|
GALLBLADDER                                 | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     1 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,COLON                       | +  +  +  +  M  +  +  +                                                    |  7       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +                                                    |  8       |
  CYST                                      |                 2                                                         |     1 2.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +                                                    |  8       |
LIVER                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1  1  1     1                                                   |     5 1.0|
  TENSION LIPOIDOSIS                        |    X           X                                                          |     2    |
  VACUOLIZATION CYTOPLASMIC                 |  1        1  1     1  1                                                   |     5 1.0|
MESENTERY                                   |                +                                                          |  1       |
PANCREAS                                    | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     2 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1  1  1  1  2                                                   |     7 1.1|
STOMACH                                     | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +                                                    |  8       |
TONGUE                                      | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +                                                    |  8       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +                                                    |  8       |
HEART                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  CARDIOMYOPATHY                            |     1                                                                     |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   53
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:38.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 3| 3| 3| 3| 3| 3| 3|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 4| 4| 4| 4| 4| 4| 4| 4|                                                      U  V   I|
CONTRL F12MTHR07     7                      | 0| 1| 2| 3| 4| 5| 6| 7|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

ADRENAL GLAND                               | M  +  +  +  +  +  +  +                                                    |  7       |
ADRENAL GLAND,CORTEX                        | M  +  +  +  +  +  +  +                                                    |  7       |
  HYPERPLASIA,SPINDLE CELL                  |     2  3  2  2  2  1                                                      |     6 2.0|
ADRENAL GLAND,MEDULLA                       | M  +  +  +  +  +  +  +                                                    |  7       |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +                                                    |  8       |
PARATHYROID GLAND                           | +  M  M  M  +  +  M  M                                                    |  3       |
PITUITARY GLAND                             | M  M  +  +  +  M  +  +                                                    |  5       |
THYROID GLAND                               | +  M  +  +  +  +  M  +                                                    |  6       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | M  +  +  +  +  M  +  +                                                    |  6       |
  ATROPHY                                   |     4  2  2        2  4                                                   |     5 2.8|
OVARY                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  ATROPHY                                   |       X     X                                                             |     2    |
UTERUS                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  1     2                                                                  |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     1 1.0|
VAGINA                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1           1  1                                                   |     3 1.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA                               |                 3                                                         |     1 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +                                                    |  8       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,LYMPHOID                      |  2        2     2                                                         |     3 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +                                                    |  8       |
SPLEEN                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |     1 2.0|
THYMUS                                      | +  +  M  +  +  +  +  +                                                    |  7       |
  ATROPHY,CORTEX                            |  3        2  2                                                            |     3 2.3|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   54
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:38.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 3| 3| 3| 3| 3| 3| 3|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 4| 4| 4| 4| 4| 4| 4| 4|                                                      U  V   I|
CONTRL F12MTHR07     7                      | 0| 1| 2| 3| 4| 5| 6| 7|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
SKIN                                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,STERNUM                                | +  +  +  +  +  +  +  +                                                    |  8       |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +                                                    |  8       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1                                                                        |     1 1.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  +  +  +  +  +  +  M                                                    |  6       |
LUNG                                        | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2     1  1  1  1  1                                                   |     7 1.1|
NOSE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
TRACHEA                                     | +  M  +  +  +  +  M  +                                                    |  6       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +                                                    |  8       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |     1 1.0|
LACRIMAL GLAND                              | M  +  +  +  +  +  +  +                                                    |  7       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2              2  1                                                   |     3 1.6|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   55
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:38.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 3| 3| 3| 3| 3| 3| 3|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 4| 4| 4| 4| 4| 4| 4| 4|                                                      U  V   I|
CONTRL F12MTHR07     7                      | 0| 1| 2| 3| 4| 5| 6| 7|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1  1  1  1  1                                                   |     7 1.0|
  NEPHROPATHY                               |     2                                                                     |     1 2.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  1  1  1                                                   |     6 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   56
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
GALLBLADDER                                 | +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
INTESTINE LARGE                             | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,COLON                       | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                              3            |          |
INTESTINE SMALL                             | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,ILEUM                       | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE SMALL,JEJUNUM                     | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  APOPTOSIS                                 |                                                                           |          |
  ATROPHY                                   |     1                                                                     |          |
  EOSINOPHILIC FOCUS                        |                                                                         X |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  1           1     1                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1     2  1     1  1     1  1  1  1  1  1  1     1  1  1  1  1  1|          |
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |          |
  LEUKOCYTOSIS                              |           1                                                               |          |
  NECROSIS                                  |        3        1  1  1  1  1     1        1        1  1     1  1     1  1|          |
  TENSION LIPOIDOSIS                        | X                    X     X              X                    X          |          |
  VACUOLIZATION CYTOPLASMIC                 |  3     2  1     1     1           1     1  1  1  1  1  1  2  1  1  2  1  1|          |
MESENTERY                                   |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |     1                                                                     |          |
  ECTASIA,DUCT                              |                                                        3                  |          |
  FOCAL CELLULAR CHANGE                     |     1     3                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1     2     1     1  1  1  1  1  1  1     1  1  1  1|          |
  INFLAMMATION                              |                                                                           |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1     1  1  1  1  2     2  1  1  1     2  1  1  1  1  2  1  1  1|          |
  INFLAMMATION                              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   57
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  MINERALIZATION                            |                                                                           |          |
STOMACH                                     | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,GLANDULAR                           | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                                                           |          |
TONGUE                                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,MAST CELL           |                          2                    2                           |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |           4                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION,EXTRA ADRENAL TISSUE         |                                                                           |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,SPINDLE CELL                  |  2  1  3  1  2  2  2  2  2  1  3  2     1  3  2  2     2  3  2  3  1  1   |          |
  VACUOLIZATION CYTOPLASMIC                 |                 1                                                         |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                                                                           |          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  M  M  +  +  M  M |          |
PITUITARY GLAND                             | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ANGIECTASIS                               |                                            1                              |          |
  CYST                                      |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                                 3         |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST,FOLLICLE                             |                                         1                                 |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   58
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  INFLAMMATION                              |                                            1                              |          |
  ULTIMOBRANCHIAL CYST                      |              2        2                    2                 2            |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ATROPHY                                   |  3  3  3     2  3  4  4        4  4  3  4  3  4  3  4  3  4  3  3  4  3   |          |
  INFLAMMATION                              |                          2                                                |          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   | X  X     X  X  X  X  X  X  X     X  X  X  X     X  X  X        X     X  X |          |
  CYST                                      |       X                                X  X                       X       |          |
  CYST,PERIOVARIAN TISSUE                   |          X     X  X     X        X           X                       X  X |          |
  HEMATOCYST                                |             X                                                             |          |
  HYPERPLASIA,ADENOMATOUS                   |                                                           3               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |     3     3                                                               |          |
  DILATATION                                |                                            4                              |          |
  FIBROSIS                                  |                    2                                                      |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2  1     3  3  2     2     2     2  2  2  2  2  2  3  2  2  3|          |
  THROMBUS                                  |           2                                                               |          |
VAGINA                                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |     3     3                                                               |          |
  DYSPLASIA                                 |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1         |          |
  INFLAMMATION                              |                                                              2            |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  HYPERPLASIA                               |        2           4                 3                                   3|          |
  HYPOPLASIA                                |     2                                                                     |          |
  PIGMENTATION                              |        3                                                                  |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,PLASMA CELL,MEDIASTINAL       |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   59
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  ATROPHY                                   |        3                                                                  |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                      2                                    |          |
  HEMORRHAGE                                |                                                                 1         |          |
  HYPERPLASIA,LYMPHOID                      |                                                  2     2     2            |          |
  HYPERPLASIA,PLASMA CELL                   |                                                                           |          |
  INFLAMMATION                              |                    2                                                      |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |  3     4                                                                  |          |
  FIBROSIS                                  |                                                              2            |          |
  HEMORRHAGE                                |           4                                                               |          |
  HYPERPLASIA,LYMPHOID                      |                                                                          3|          |
  HYPERPLASIA,PLASMA CELL                   |                                                                           |          |
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |        4                                                                  |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  3     4           3                                                      |          |
  HYPERPLASIA,LYMPHOID                      |                 1     1     2     1              3              3         |          |
  HYPERPLASIA,PLASMA CELL,RED PULP          |                                                                           |          |
THYMUS                                      | +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  + |          |
  ATROPHY,CORTEX                            |  4     4        3     4     2     3     3  3     4  3        2  2  2  3  3|          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                       2                 2                          1  2  2|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  + |          |
  GALACTOCELE                               |                                                                           |          |
  LACTATION                                 |                                                                           |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                    1              3        1           1           1      |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                 1  1  2     2     3     3  2     1  1  4  3  2     3  1  3|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   60
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

SKELETAL MUSCLE                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          2                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1              1  1  2  1  1  1  1     1     1  2        1              1|          |
PERIPHERAL NERVE                            | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1                                       |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                       1   |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |           3                                                               |          |
  HEMORRHAGE                                |           2                                                               |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |              3  2                                                         |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |           2                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1              1  1  1  1  1     1        1     1  1  1     1  2  1  1  2|          |
  INFLAMMATION                              |                 2                       1                    1        1   |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                       2   |          |
HARDERIAN GLAND                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                       2   |          |
  HYPERPLASIA                               |                                                  4                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   61
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1     1                       1  1  1               |          |
LACRIMAL GLAND                              | +  +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  APOPTOSIS                                 |     1                                                                     |          |
  ATROPHY                                   |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1        1        2           1  1     2  1  1        1  1  1   |          |
  NECROSIS                                  |                                                                           |          |
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |     4                                                                     |          |
  CYST,RENAL TUBULE                         |     2           1                          1  1        1                  |          |
  INFARCT                                   |                                                              1            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2     1  1  2  1  1  1  3  1     1  1     1     1  2  1  1  1  1  1  2   |          |
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |          |
  INFLAMMATION,ADVENTITIA                   |                                                                           |          |
URINARY BLADDER                             | +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1              1  1  1  1  1     1     1  1     1  1  1  1  2  2  2  1   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   62
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:01.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  M  +  +  M  +  M  +  M                               | 36       |
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                 1                                                |     2 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  INFLAMMATION                              |                                                                           |     1 3.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE SMALL,ILEUM                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 35       |
  HYPERPLASIA,LYMPHOID                      |  2                       2                                                |     2 2.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,LYMPHOID                      |                 2        2                                                |     2 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  APOPTOSIS                                 |                       4                                                   |     1 4.0|
  ATROPHY                                   |                                                                           |     1 1.0|
  EOSINOPHILIC FOCUS                        |                                                                           |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     3 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1  2        1     2     2  1  1                              |    27 1.1|
  INFILTRATION CELLULAR,PLASMA CELL         |                       3                                                   |     1 3.0|
  LEUKOCYTOSIS                              |                                                                           |     1 1.0|
  NECROSIS                                  |  1  1  1  1  1  1  1        1  1           1                              |    24 1.0|
  TENSION LIPOIDOSIS                        |       X     X           X     X           X                               |    10    |
  VACUOLIZATION CYTOPLASMIC                 |  1  1  1  1  1  1  2     1  1  1        1                                 |    29 1.2|
MESENTERY                                   |                      +                                                    |  1       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     1 2.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     1 1.0|
  ECTASIA,DUCT                              |                                                                           |     1 3.0|
  FOCAL CELLULAR CHANGE                     |                                                                           |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2  1              2     2     1  1                                 |    21 1.1|
  INFLAMMATION                              |                       4                                                   |     1 4.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  3  2  1     2     1  1  2  1  1  1  1                              |    33 1.2|
  INFLAMMATION                              |                       3                                                   |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   63
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  MINERALIZATION                            |                                      2                                    |     1 2.0|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  CYST                                      |     2                                                                     |     1 2.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,MAST CELL           |                                                                           |     2 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |     1 1.0|
  INFLAMMATION                              |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFLAMMATION,EXTRA ADRENAL TISSUE         |                       4                                                   |     1 4.0|
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  HYPERPLASIA,SPINDLE CELL                  |  2  2  2  2  3  2  2  3  2  2  4  1  2  1  2                              |    37 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 1.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CONGESTION                                |                                      2                                    |     1 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                       2                                                   |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
PARATHYROID GLAND                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 31       |
PITUITARY GLAND                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                               | 36       |
  ANGIECTASIS                               |                                                                           |     1 1.0|
  CYST                                      |              2                                                            |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |                    2     4                                                |     3 3.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CYST,FOLLICLE                             |                                                                           |     1 1.0|
  HYPERPLASIA,FOLLICULAR CELL               |     1                                                                     |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1                    2                                    |     2 1.5|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   64
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  INFLAMMATION                              |                                                                           |     1 1.0|
  ULTIMOBRANCHIAL CYST                      |  2     3  2        2              2                                       |     9 2.1|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                               | 37       |
  ATROPHY                                   |  4  3  3  3  3  4  3  3  4  2     3  3  4  4                              |    35 3.3|
  INFLAMMATION                              |                                                                           |     1 2.0|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   | X  X     X  X  X  X  X  X  X  X  X  X  X  X                               |    33    |
  CYST                                      |       X                    X                                              |     6    |
  CYST,PERIOVARIAN TISSUE                   | X              X  X           X                                           |    12    |
  HEMATOCYST                                |                   X                                                       |     2    |
  HYPERPLASIA,ADENOMATOUS                   |                                2        3                                 |     3 2.6|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  3                    3              2                                    |     3 2.6|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     2 3.0|
  DILATATION                                |                                                                           |     1 4.0|
  FIBROSIS                                  |                                                                           |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  3  2  2  3  3  2  3  2  3  2  3  3  3  1  3                              |    32 2.3|
  THROMBUS                                  |                                                                           |     1 2.0|
VAGINA                                      | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  ATROPHY                                   |                                                                           |     2 3.0|
  DYSPLASIA                                 |                 3                                                         |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |     2 1.0|
  INFLAMMATION                              |                 4                                                         |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  HYPERPLASIA                               |                       4              2                                    |     6 3.0|
  HYPOPLASIA                                |                                                                           |     1 2.0|
  PIGMENTATION                              |                                                                           |     1 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  HYPERPLASIA,PLASMA CELL,MEDIASTINAL       |                       4                                                   |     1 4.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   65
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  ATROPHY                                   |                                                                           |     1 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     1 2.0|
  HEMORRHAGE                                |                                                                           |     1 1.0|
  HYPERPLASIA,LYMPHOID                      |  2           3                                                            |     5 2.2|
  HYPERPLASIA,PLASMA CELL                   |                       4                                                   |     1 4.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     2 3.5|
  FIBROSIS                                  |                                                                           |     1 2.0|
  HEMORRHAGE                                |                                                                           |     1 4.0|
  HYPERPLASIA,LYMPHOID                      |     2                                                                     |     2 2.5|
  HYPERPLASIA,PLASMA CELL                   |                       4                                                   |     1 4.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                       3                                                   |     2 3.5|
  HEMATOPOIETIC CELL PROLIFERATION          |                       4                                                   |     4 3.5|
  HYPERPLASIA,LYMPHOID                      |     1        3                 3     3                                    |    10 2.1|
  HYPERPLASIA,PLASMA CELL,RED PULP          |                       4                                                   |     1 4.0|
THYMUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +                               | 33       |
  ATROPHY,CORTEX                            |  3  2     3  2        4  2  3  3  2                                       |    24 2.8|
  HYPERPLASIA,LYMPHOID,MEDULLA              |        3     2     2     2     2  2  3     2                              |    13 2.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +                               | 36       |
  GALACTOCELE                               |                             2                                             |     1 2.0|
  LACTATION                                 |                                   2                                       |     1 2.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 2                                                         |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  FIBROUS OSTEODYSTROPHY                    |  2                       1  1     1                                       |     9 1.3|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  2  1     2  3  1  2  2  2  4  3  1  2  4                                 |    28 2.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   66
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1                                                            |     2 1.5|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                          1                                       |     2 1.0|
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     1     1  1  1     1           1  1  1                                 |    21 1.0|
PERIPHERAL NERVE                            | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CONGESTION                                |                                                                           |     1 3.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |     2 2.5|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  2  1  2  1  1     1  1  1  2  1                              |    30 1.1|
  INFLAMMATION                              |                                                                           |     4 1.2|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  INFLAMMATION                              |                                                                           |     1 2.0|
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                               | 38       |
  ATROPHY                                   |                                                                           |     1 2.0|
  HYPERPLASIA                               |        4                                                                  |     2 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   67
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1     1  1     1     1        1                                 |    13 1.0|
LACRIMAL GLAND                              | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +                               | 33       |
  APOPTOSIS                                 |                                                                           |     1 1.0|
  ATROPHY                                   |     2                                                                     |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2     1     1  3  1        1  1     1                              |    21 1.2|
  NECROSIS                                  |                       2                                                   |     1 2.0|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                               | 38       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |     1 4.0|
  CYST,RENAL TUBULE                         |  1  1                       1           1                                 |     9 1.1|
  INFARCT                                   |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2  1     1     2     1  1  2  1  1  1  1                              |    31 1.2|
  INFILTRATION CELLULAR,PLASMA CELL         |                       2                                                   |     1 2.0|
  INFLAMMATION,ADVENTITIA                   |                       2                                                   |     1 2.0|
URINARY BLADDER                             | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2     2  2  2  1  1  2  1  1  1  2  1                              |    31 1.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   68
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:15.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DILATATION                                |           2                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
GALLBLADDER                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1                                                         |          |
  INFLAMMATION                              |                                                                           |          |
INTESTINE LARGE                             | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                         2                                 |          |
INTESTINE LARGE,COLON                       | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL                             | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE SMALL,ILEUM                       | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                   3                                       |          |
INTESTINE SMALL,JEJUNUM                     | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,GOBLET CELL                   |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                                                                       2   |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                      X    |          |
  DEGENERATION,CENTRILOBULAR                |                       2                                                   |          |
  EOSINOPHILIC FOCUS                        |                                  X                    X                   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  2     2  2                                1                    2         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                 1     1  1  2  3  1  1  1  1  1  1  2  2  1  1  1  2|          |
  NECROSIS                                  |                             1  1  1  1  1  1     1     1  1  1  1  2  1  1|          |
  NECROSIS,COAGULATIVE                      |     2  2           2                                                      |          |
  TENSION LIPOIDOSIS                        |                                  X              X  X     X        X       |          |
  VACUOLIZATION CYTOPLASMIC                 |  2           1  1           1     2  1     1        1  1  2  1  1  1  1  1|          |
MESENTERY                                   |                   +                                                       |          |
  NECROSIS,FAT                              |                                                                           |          |
PANCREAS                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                    4      |          |
  FOCAL CELLULAR CHANGE                     |                                               1              1            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     2              1           1  1     1     1           1     2  2  1|          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   69
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |           3                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2           1  2  2     2  1  2  2  1  1  1     2  2  2  1  1  1  1  2|          |
STOMACH                                     | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |                                                                           |          |
STOMACH,GLANDULAR                           | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                2                                          |          |
  INFLAMMATION                              |                                                                           |          |
TONGUE                                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CARDIOMYOPATHY                            |     2                                                                     |          |
  INFLAMMATION                              |           2                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  A  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | +  A  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,FATTY                        |                                                     2                     |          |
  ECTOPIC TISSUE                            |                                     X                                     |          |
  FOCAL CELLULAR CHANGE                     |                                         3                                 |          |
  HYPERPLASIA,SPINDLE CELL                  |  2     2  1  1  2  2        2  2  2     2  1  3  2  4  1  3  2  2  1  2  2|          |
ADRENAL GLAND,MEDULLA                       | +  A  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYTOPLASMIC ALTERATION                    |                                                                           |          |
ISLETS, PANCREATIC                          | +  A  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M |          |
  ECTOPIC THYMUS                            |                                                                   X       |          |
PITUITARY GLAND                             | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                                           |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |                                                                           |          |
  GOITER ADENOMATOUS                        |                       2                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   70
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             2                                             |          |
  ULTIMOBRANCHIAL CYST                      |                       2     2              2     2        2     2         |          |
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |                      +                                                    |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  + |          |
  ATROPHY                                   |     2        4  3           3  4  4     4  4  4  3  2     3  3     3  3  3|          |
  INFLAMMATION                              |                 2                                   1                     |          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   | X  X  X  X     X  X  X     X  X  X  X  X  X  X  X  X  X     X  X  X  X  X |          |
  CYST                                      | X                                   X        X        X                   |          |
  CYST,PERIOVARIAN TISSUE                   |                            X  X           X              X                |          |
  HEMATOCYST                                |                   X                    X           X                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  OVOTESTIS                                 |                                                                           |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           3           3                                                   |          |
  DILATATION                                |  4                    2                                                   |          |
  FIBROSIS                                  |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2  2           4  2     4  2  2  1  3  2  3     2     1  1   |          |
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |  3        3                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEPLETION                                 |                             2                                             |          |
  HYPERPLASIA                               |     3     4                                                     4         |          |
  PIGMENTATION                              |                                                     2                     |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,PLASMA CELL                   |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   71
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  INFLAMMATION                              |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                           |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |  3        2           2     2           4     3        2              2   |          |
LYMPH NODE,MESENTERIC                       | +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  HEMORRHAGE                                |                                                                    2      |          |
  HYPERPLASIA,LYMPHOID                      |                             3                                   2         |          |
  HYPERPLASIA,PLASMA CELL                   |                                                                           |          |
  HYPERPLASIA,RETICULUM CELL                |                                                                    2      |          |
  INFLAMMATION                              |  3                                                                        |          |
SPLEEN                                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION                        |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  4     3  3        3                 3                          3        3|          |
  HYPERPLASIA,LYMPHOID                      |                 1           2                 3     2  2  2        3     1|          |
THYMUS                                      | +  M  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  + |          |
  ATROPHY,CORTEX                            |  3              4              4  4  3  3  3  2     2  2     3  2  3      |          |
  CYST                                      |                                                                           |          |
  ECTOPIC PARATHYROID GLAND                 |                                                                X          |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                             3              2           2           3     1|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |  2                                                                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
  LACTATION                                 |                                                  2                        |          |
  METAPLASIA,SQUAMOUS                       |    X                                                                      |          |
SKIN                                        | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   72
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY                    |                             2                          2                  |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                             3  2  1  1  2  3  3     1  2  3  1     2      |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                       1  1     1  1  1  1     1  1  1     2  1        1  1|          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMORRHAGE                                |                                                           3               |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                               2                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                1                                          |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1     2  1     1  1  1  2  1           1  2  2  1  2  1  1  2|          |
  INFLAMMATION                              |           4                                                               |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DILATATION,GLANDS                         |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2                              |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  A  A  A  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             1                 1     1        1     1  1  1|          |
LACRIMAL GLAND                              | +  +  +  M  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   73
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2                          2  1        1     1           2           1   |          |
ZYMBAL'S GLAND                              | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                     4                     |          |
  CYST,RENAL TUBULE                         |              1                 1  1     1  1  1           1  1            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  1  1  1     1  1  1  1     1  2  1  2  1     1  1  1  1  1|          |
  NECROSIS,COAGULATIVE                      |        1                                                                  |          |
  NEPHROPATHY                               |                                                     1                     |          |
URINARY BLADDER                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1           1  2  1     2  1  1  2     1  1     2  1  1  1  1  2  1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   74
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:24.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DILATATION                                |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     1 1.0|
GALLBLADDER                                 | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +                               | 36       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2  1                                                |     4 1.2|
  INFLAMMATION                              |     1                                                                     |     1 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,LYMPHOID                      |                                   2                                       |     2 2.0|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,LYMPHOID                      |           2                                                               |     1 2.0|
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,LYMPHOID                      |           2     2                                                         |     3 2.3|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,GOBLET CELL                   |                       2                                                   |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |                          2                                                |     2 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  BASOPHILIC FOCUS                          | X                                      X                                  |     3    |
  DEGENERATION,CENTRILOBULAR                |                                                                           |     1 2.0|
  EOSINOPHILIC FOCUS                        |                                                                           |     2    |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     5 1.8|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1     1  1  1  1     1  1     1  1                              |    29 1.2|
  NECROSIS                                  |     1        1  1                 1  1  1  1                              |    21 1.0|
  NECROSIS,COAGULATIVE                      |                                                                           |     3 2.0|
  TENSION LIPOIDOSIS                        |    X        X        X     X        X                                     |    10    |
  VACUOLIZATION CYTOPLASMIC                 |     1  1  1  1  1  1  1  1     1  1  1  1  1                              |    28 1.1|
MESENTERY                                   |    +                                                                      |  2       |
  NECROSIS,FAT                              |     4                                                                     |     1 4.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                                                                           |     1 4.0|
  FOCAL CELLULAR CHANGE                     |                                                                           |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1                    1  1        1                                 |    16 1.1|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   75
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |              4           2                                                |     3 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2  1  1  1  2  2  1  1  1  1  2  1  1                              |    35 1.4|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  HYPERKERATOSIS                            |                       2                                                   |     1 2.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  CYST                                      |           1                 1                                             |     3 1.3|
  INFLAMMATION                              |           1                                                               |     1 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +  +  +  +  +  +  +  +  +  +  M  +  +                               | 35       |
BLOOD VESSEL,AORTA                          | M  M  +  +  +  +  +  +  +  +  +  +  M  +  +                               | 35       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CARDIOMYOPATHY                            |                                                                           |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  DEGENERATION,FATTY                        |                                                                           |     1 2.0|
  ECTOPIC TISSUE                            |                                                                           |     1    |
  FOCAL CELLULAR CHANGE                     |              2                                                            |     2 2.5|
  HYPERPLASIA,SPINDLE CELL                  |  1  1  2  2  2  2  2  3  1  3  1  1  2                                    |    34 1.8|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  CYTOPLASMIC ALTERATION                    |              2                                                            |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
PARATHYROID GLAND                           | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +                               | 33       |
  ECTOPIC THYMUS                            |                                                                           |     1    |
PITUITARY GLAND                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                               | 36       |
  HYPERPLASIA,PARS DISTALIS                 |     2                                                                     |     1 2.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DEGENERATION                              |                                         2                                 |     1 2.0|
  GOITER ADENOMATOUS                        |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   76
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  HYPERPLASIA,FOLLICULAR CELL               |                    2                                                      |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |     2 1.5|
  ULTIMOBRANCHIAL CYST                      |                 2                    2                                    |     8 2.0|
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +                               | 33       |
  ATROPHY                                   |  3  3  3  4  3  3  3     3  3  3  4     3  4                              |    29 3.2|
  INFLAMMATION                              |                                                                           |     2 1.5|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                               | 39       |
  ATROPHY                                   | X  X  X  X  X  X  X  X           X  X  X  X                               |    34    |
  CYST                                      |       X                                X                                  |     6    |
  CYST,PERIOVARIAN TISSUE                   |          X                       X                                        |     6    |
  HEMATOCYST                                |             X           X                                                 |     5    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     1 2.0|
  OVOTESTIS                                 |                                            1                              |     1 1.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     2 3.0|
  DILATATION                                |                          4                                                |     3 3.3|
  FIBROSIS                                  |     2                                                                     |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2  2  3  2  3     2  4     2  4  2  1  2                                 |    26 2.3|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DEPLETION                                 |                                                                           |     1 2.0|
  HYPERPLASIA                               |              2                                                            |     4 3.2|
  PIGMENTATION                              |                                                                           |     1 2.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  HYPERPLASIA,PLASMA CELL                   |     4                                                                     |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   77
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  INFLAMMATION                              |     2                                                                     |     1 2.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |              3                                                            |     1 3.0|
  HEMORRHAGE                                |                    2                                                      |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |           2              2                                                |    10 2.4|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  ANGIECTASIS                               |                                            4                              |     1 4.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |                    2                 2                                    |     4 2.2|
  HYPERPLASIA,PLASMA CELL                   |                       4                                                   |     1 4.0|
  HYPERPLASIA,RETICULUM CELL                |                                                                           |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 3.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  AMYLOID DEPOSITION                        |                                2                                          |     1 2.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     7 3.1|
  HYPERPLASIA,LYMPHOID                      |                          3              1  1                              |    11 1.9|
THYMUS                                      | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 31       |
  ATROPHY,CORTEX                            |     2  3              4  2     3        3  2                              |    20 2.8|
  CYST                                      |                 2                                                         |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |     2           2        2  3  2        3  2                              |    12 2.2|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                               | 38       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  LACTATION                                 |                                                                           |     1 2.0|
  METAPLASIA,SQUAMOUS                       |                                                                           |     1    |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   78
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY                    |                       1  1              1                                 |     5 1.4|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  1     2  1  2  2  1  4  1  3  2  2  2  2                                 |    25 1.9|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     1  1  1  1  1     1     1  1  1     1                                 |    23 1.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFLAMMATION                              |  1                                                                        |     1 1.0|
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                               | 34       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  HEMORRHAGE                                |                                                                           |     1 3.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |  1                                                                        |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1     1  1  2  1  2  1  1  2  1  1                              |    29 1.3|
  INFLAMMATION                              |           1                                                               |     2 2.5|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DILATATION,GLANDS                         |                 3                                                         |     1 3.0|
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 34       |
HARDERIAN GLAND                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +                               | 38       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1  1     1        1  1  1  1  1                              |    16 1.0|
LACRIMAL GLAND                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +                               | 33       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   79
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2  1  1        2  1  1     1        1                              |    17 1.2|
ZYMBAL'S GLAND                              | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |     1 4.0|
  CYST,RENAL TUBULE                         |        1                                                                  |     9 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1           1     1  2  1  1  2  1                              |    31 1.1|
  NECROSIS,COAGULATIVE                      |                                                                           |     1 1.0|
  NEPHROPATHY                               |                       1                                                   |     2 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1     1  2  1  1  1  1  1  2  1                              |    33 1.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   80
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:39.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
GALLBLADDER                                 | +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            1     1     1              1   |          |
INTESTINE LARGE                             | A  +  A  +  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | A  A  A  A  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,COLON                       | A  +  A  +  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,GOBLET CELL                   |           3                                                               |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,RECTUM                      | A  +  A  M  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
INTESTINE SMALL                             | A  A  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | A  A  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
INTESTINE SMALL,ILEUM                       | A  A  A  A  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  HYPERPLASIA,LYMPHOID                      |                                            4                              |          |
INTESTINE SMALL,JEJUNUM                     | A  A  A  A  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  CLEAR CELL FOCUS                          |                X                                                          |          |
  DEGENERATION,CYSTIC                       |                                                                       3   |          |
  DEGENERATION,FATTY                        |                                                                           |          |
  EOSINOPHILIC FOCUS                        |                                                          X  X           X |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                 2                                                         |          |
  HYPERPLASIA,KUPFFER CELL                  |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1        1  1  2  1  1        1  1  1  1     1  1     1     2|          |
  MIXED CELL FOCUS                          |                                                                           |          |
  NECROSIS                                  |                       1  1  1  1  1  1  1        1  1  1        1  1  1   |          |
  NECROSIS,COAGULATIVE                      |                                                                           |          |
  TENSION LIPOIDOSIS                        |                                        X  X     X                         |          |
  VACUOLIZATION CYTOPLASMIC                 |  1        1  1        1  1  1              1  1  1  1  1  1  1  1  1      |          |
PANCREAS                                    | +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FOCAL CELLULAR CHANGE                     |                                               1                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                             1     1  1  1  1           1  1  1  1  1|          |
SALIVARY GLANDS                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                             2           2                                 |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1           1  1  2  1  2  1  1  1  1  1  1  1  1     1  1     1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   81
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  MINERALIZATION                            |                                                                           |          |
STOMACH                                     | +  +  A  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | A  +  A  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |                                                                       2   |          |
  HYPERPLASIA                               |                                                                           |          |
  ULCER                                     |                             3                                             |          |
STOMACH,GLANDULAR                           | +  +  A  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                      1  1                                 |          |
  HYPERPLASIA                               |                                                     1                     |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                 3                                                         |          |
  DILATATION                                |                 4                                                         |          |
  HEMORRHAGE,VALVE                          |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  A  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | +  +  A  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                 3                                                         |          |
  DEGENERATION,FATTY                        |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |  2              2     1  2  2  2  2  2  2  2  3  2  2  2     1     1  2  2|          |
  VACUOLIZATION CYTOPLASMIC                 |                                                           2               |          |
ADRENAL GLAND,MEDULLA                       | +  +  A  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                 3                                                         |          |
ISLETS, PANCREATIC                          | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                          1                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
PARATHYROID GLAND                           | +  +  A  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTOPIC THYMUS                            |                                                                           |          |
PITUITARY GLAND                             | +  +  A  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   82
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  CYST                                      |     2                                                                     |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                        2                  |          |
THYROID GLAND                               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST,FOLLICLE                             |                             2                                             |          |
  DEGENERATION                              |                                                                           |          |
  ECTOPIC THYMUS                            |                                                          X                |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |          |
  HYPERTROPHY,FOLLICULAR CELL               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1                                       |          |
  ULTIMOBRANCHIAL CYST                      |                          2                                   2     2  2   |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  A  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  + |          |
  ATROPHY                                   |  2  4     3  3  3     3  3  3  3  3     4  3  3     3  3  3     3  3     3|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             1                                             |          |
OVARY                                       | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |    X     X  X  X     X  X     X  X  X  X        X  X  X  X  X  X  X  X  X |          |
  CYST                                      |                                           X              X     X          |          |
  CYST,PERIOVARIAN TISSUE                   |                      X  X  X                 X     X  X                   |          |
  HEMATOCYST                                |                                                             X             |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             1                                             |          |
  MINERALIZATION                            |                                                                           |          |
UTERUS                                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |              3                                                            |          |
  DILATATION                                |                                                                           |          |
  ECTASIA,VEIN                              |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |                       2  4     1  3  2  3  3  2  3  4  3  2  3  2  2  4  3|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |              2                                                            |          |
VAGINA                                      | +  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  METAPLASIA                                |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   83
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |  3              3                                               3         |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                            2                              |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                           |          |
  CONGESTION,SINUS                          |                                                                           |          |
  HEMORRHAGE                                |                                2                                          |          |
  HYPERPLASIA,LYMPHOID                      |                             2           3                                 |          |
SPLEEN                                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                 2                                                         |          |
  CONGESTION                                |                                                                       1  2|          |
  ERYTHROPHAGOCYTOSIS                       |                                   1                                       |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  4              4                                                         |          |
  HYPERPLASIA,LYMPHOID                      |                          1  2     1  3  1           2           2     1   |          |
THYMUS                                      | +  +  A  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M |          |
  ATROPHY,CORTEX                            |  3           3        4  3  2  2  3  2  3  4  4  3  2     4     3  3      |          |
  CONGESTION                                |                                                                 2         |          |
  ECTOPIC PARATHYROID GLAND                 |                                  X                                        |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                            2                    2         |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  A  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                                          2|          |
SKIN                                        | +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ALOPECIA                                  |                 4                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,CARTILAGE                    |                                                                           |          |
  FIBROUS OSTEODYSTROPHY                    |                       3  2                                3  1           1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   84
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                    3  3  4  1  1  1  1  3  2  2  2  1  3  3  2        3  2|          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                     1                     |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                    1     1  1  1  1     1     1        1  1  1  1  1  1  1|          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  M  A  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONCRETION                                |                                                                           |          |
  CRYSTALS                                  |                                                                           |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |           4                                                               |          |
  GIANT CELL                                |                                                                           |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                      1                 1                  |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                     2                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1              1  1  1  1  1  1  1  1     1     1     1  1     1|          |
  INFLAMMATION                              |                                                                           |          |
  THROMBUS,CAPILLARY                        |                 4                                                         |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
TRACHEA                                     | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                             2                                             |          |
  FOREIGN BODY                              |                                                                         X |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   85
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | A  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HARDERIAN GLAND                             | +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                 1                 1        1      |          |
  INFLAMMATION                              |                                                                           |          |
LACRIMAL GLAND                              | +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ATROPHY                                   |                       2                                                   |          |
  CYTOMEGALY                                |                                                                           |          |
  ECTASIA,DUCT                              |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1     1                          1  1  1  1  1           1      |          |
ZYMBAL'S GLAND                              | +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                 3                                                         |          |
  CYST,RENAL TUBULE                         |                                1              1  1     1        1     1   |          |
  GLOMERULOSCLEROSIS                        |                 3                                                         |          |
  HYDRONEPHROSIS                            |                                                        1                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  2     1  2  1  1  1  1  1  1  1  1  1  1  1     1  3  2  1|          |
  NEPHROPATHY                               |                                                                       1   |          |
  PIGMENTATION,RENAL TUBULE                 |                                                                       1   |          |
URINARY BLADDER                             | +  +  A  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2        1           1  1  2  1  1  1  1     1  1  1  1  1     1  1      |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   86
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +                               | 36       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1        2                                                      |     6 1.1|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 34       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 32       |
  HYPERPLASIA,LYMPHOID                      |                    2     2        2     2                                 |     4 2.0|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 34       |
  HYPERPLASIA,GOBLET CELL                   |                                                                           |     1 3.0|
  HYPERPLASIA,LYMPHOID                      |                                      2                                    |     1 2.0|
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 32       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 33       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 33       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          2                                                |     1 2.0|
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 31       |
  HYPERPLASIA,LYMPHOID                      |                                         2                                 |     2 3.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 32       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  BASOPHILIC FOCUS                          |                   X                       X                               |     2    |
  CLEAR CELL FOCUS                          |                                           X                               |     2    |
  DEGENERATION,CYSTIC                       |                                                                           |     1 3.0|
  DEGENERATION,FATTY                        |                                            2                              |     1 2.0|
  EOSINOPHILIC FOCUS                        |                                                                           |     3    |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     1 2.0|
  HYPERPLASIA,KUPFFER CELL                  |                                         3                                 |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1     1  1  1  1  2     1  1     1  1                              |    27 1.1|
  MIXED CELL FOCUS                          |                         X                                                 |     1    |
  NECROSIS                                  |  1  1           1  1        1  1  1                                       |    20 1.0|
  NECROSIS,COAGULATIVE                      |                                            2                              |     1 2.0|
  TENSION LIPOIDOSIS                        |          X  X  X        X  X                                              |     8    |
  VACUOLIZATION CYTOPLASMIC                 |  1                 1  1     1  1  1  1  2  1                              |    24 1.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  FOCAL CELLULAR CHANGE                     |  1                                                                        |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1        1                 1     2                              |    16 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                          1                                                |     3 1.6|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1  1  1  1     2  1  2  1  1  1  1     2                              |    31 1.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   87
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  MINERALIZATION                            |                                         1                                 |     1 1.0|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 35       |
  HYPERKERATOSIS                            |                          2                                                |     2 2.0|
  HYPERPLASIA                               |     2                                                                     |     1 2.0|
  ULCER                                     |                                                                           |     1 3.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
  CYST                                      |                                                                           |     2 1.0|
  HYPERPLASIA                               |                                                                           |     1 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +                               | 37       |
BLOOD VESSEL,AORTA                          | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +                               | 37       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  CONGESTION                                |                                                                           |     1 3.0|
  DILATATION                                |                                                                           |     1 4.0|
  HEMORRHAGE,VALVE                          |    X                                                                      |     1    |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  CONGESTION                                |                                                                           |     1 3.0|
  DEGENERATION,FATTY                        |                                         4                                 |     1 4.0|
  HYPERPLASIA,SPINDLE CELL                  |  2  2  2  2  2  3  2  1  2  1  2  3  1     3                              |    32 1.9|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 2.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  CONGESTION                                |                                                                           |     1 3.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  HYPERPLASIA                               |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |     1 1.0|
PARATHYROID GLAND                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                               | 36       |
  ECTOPIC THYMUS                            | X                                                                         |     1    |
PITUITARY GLAND                             | +  +  +  +  +  +  +  M  +  +  +  +  M  +  M                               | 33       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   88
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  CYST                                      |                                                                           |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |                                                                           |     1 2.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  CYST,FOLLICLE                             |     2                       1                                             |     3 1.6|
  DEGENERATION                              |                       1                                                   |     1 1.0|
  ECTOPIC THYMUS                            |                                                                           |     1    |
  HYPERPLASIA,FOLLICULAR CELL               |                                         2                                 |     1 2.0|
  HYPERTROPHY,FOLLICULAR CELL               |                                         2                                 |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2                              |     2 1.5|
  ULTIMOBRANCHIAL CYST                      |              2     2                       3                              |     7 2.1|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M                               | 33       |
  ATROPHY                                   |  3     3  3  3     3  3  4  3  3  3  4  3                                 |    31 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  ANGIECTASIS                               |        2                                                                  |     1 2.0|
  ATROPHY                                   | X        X  X  X  X  X  X  X  X  X  X  X  X                               |    32    |
  CYST                                      |    X     X  X           X        X  X                                     |     9    |
  CYST,PERIOVARIAN TISSUE                   |          X     X                                                          |     8    |
  HEMATOCYST                                |             X  X                          X                               |     4    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  MINERALIZATION                            |           2                                                               |     1 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                                                                           |     1 3.0|
  DILATATION                                |                                      3                                    |     1 3.0|
  ECTASIA,VEIN                              |                                            2                              |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  3  2     2  2  3  2  3     2  2  2     2  2                              |    29 2.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2                              |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  METAPLASIA                                |        4                                                                  |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   89
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  HYPERPLASIA                               |                                                                           |     3 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  HYPERPLASIA,LYMPHOID                      |              2           2     3                                          |     4 2.2|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                          2                                                |     1 2.0|
  CONGESTION,SINUS                          |              2                                                            |     1 2.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |     2                                2                                    |     4 2.2|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                                                                           |     1 2.0|
  CONGESTION                                |  2                                                                        |     3 1.6|
  ERYTHROPHAGOCYTOSIS                       |                                                                           |     1 1.0|
  HEMATOPOIETIC CELL PROLIFERATION          |           3                          3                                    |     4 3.5|
  HYPERPLASIA,LYMPHOID                      |  1     1                 2           3                                    |    12 1.6|
THYMUS                                      | +  M  +  +  +  +  +  M  M  +  +  +  M  +  +                               | 30       |
  ATROPHY,CORTEX                            |        4  3  3  3           2  1  3     3  3                              |    25 2.9|
  CONGESTION                                |                                                                           |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                 2  3        1              3                              |     6 2.1|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                               | 36       |
  HYPERPLASIA                               |     2  3                                                                  |     3 2.3|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  ALOPECIA                                  |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DEGENERATION,CARTILAGE                    |                                            4                              |     1 4.0|
  FIBROUS OSTEODYSTROPHY                    |  1                       1        2     2                                 |     9 1.7|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   90
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  2  1     2     3  1  2  3     1  2  2  3  2                              |    29 2.1|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     2     1  1  1  1  1     1  1     1  1                                 |    24 1.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +                               | 34       |
  CONCRETION                                |     2                                                                     |     1 2.0|
  CRYSTALS                                  |                          1                                                |     1 1.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CONGESTION                                |                                                                           |     1 4.0|
  GIANT CELL                                |                          2                                                |     1 2.0|
  HEMORRHAGE                                |                    2     2                                                |     2 2.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |     2 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                    1                                                      |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1     1  1     2  1  1  2  2  2  2                              |    27 1.1|
  INFLAMMATION                              |                             1  1        1                                 |     3 1.0|
  THROMBUS,CAPILLARY                        |                                                                           |     1 4.0|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  CYST                                      |                                                                           |     1 2.0|
  FOREIGN BODY                              |                                                                           |     1    |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   91
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 35       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1           1           1                                                |     8 1.0|
  INFLAMMATION                              |                    4                                                      |     1 4.0|
LACRIMAL GLAND                              | M  M  +  +  +  +  M  +  +  M  +  +  +  +  +                               | 32       |
  ATROPHY                                   |                                         2                                 |     2 2.0|
  CYTOMEGALY                                |                                         2                                 |     1 2.0|
  ECTASIA,DUCT                              |                          2                                                |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1        3        1        2                              |    13 1.2|
ZYMBAL'S GLAND                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                      2                                    |     2 2.5|
  CYST,RENAL TUBULE                         |           1                                3                              |     8 1.2|
  GLOMERULOSCLEROSIS                        |                                                                           |     1 3.0|
  HYDRONEPHROSIS                            |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1     1  1  1     1        1  1  2                              |    32 1.1|
  NEPHROPATHY                               |                    1     2  1                                             |     4 1.2|
  PIGMENTATION,RENAL TUBULE                 |                                                                           |     1 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1  1  1  1  1  2  2     1  1  1                                 |    28 1.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   92
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:04.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
GALLBLADDER                                 | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1                                         1      |          |
INTESTINE LARGE                             | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |          |
INTESTINE LARGE,COLON                       | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,GOBLET CELL                   |              3                                                            |          |
INTESTINE LARGE,RECTUM                      | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROSIS                                  |              3                                                            |          |
INTESTINE SMALL                             | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,ILEUM                       | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
  ATROPHY                                   |              2                                                            |          |
INTESTINE SMALL,JEJUNUM                     | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                 2                       1           1  1                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1     1  1  2  1  1  1  2  1  2  1  3  2  1  1  1  1  1     1  1  1  1|          |
  INFLAMMATION                              |                                            1                              |          |
  NECROSIS                                  |              1     1           1  1              1        1        1     1|          |
  NECROSIS,COAGULATIVE                      |                                                                 1         |          |
  TENSION LIPOIDOSIS                        |                   X  X                             X     X  X  X     X  X |          |
  VACUOLIZATION CYTOPLASMIC                 |  1  1        1                 1           1              1     1  1  2  1|          |
MESENTERY                                   |                                                          +                |          |
  NECROSIS,FAT                              |                                                           4               |          |
PANCREAS                                    | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           1                                                              1|          |
  DEGENERATION                              |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                 1           1  1  1  1  1              1  1     1  1  1|          |
  INFLAMMATION                              |                 2                                                         |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2     1        1     2  1  1  2  2  1  1  2     2  1  2  1  2  2  2  1|          |
STOMACH                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   93
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:04.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  HYPERKERATOSIS                            |                                                                           |          |
STOMACH,GLANDULAR                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                          2                    1                           |          |
  HYPERPLASIA                               |                          2                                                |          |
  MINERALIZATION                            |                          1                                                |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,MAST CELL           |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CARDIOMYOPATHY                            |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1         |          |
  THROMBUS                                  |        2                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                                           |          |
ADRENAL GLAND,CORTEX                        | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |  2     1  3  2  2  3  3  3  2  2  3  2  2  2  2  2  2  2  1  2  1  2     2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  VACUOLIZATION CYTOPLASMIC                 |                    2                                                      |          |
ADRENAL GLAND,MEDULLA                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |  3                                                                        |          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ISLETS, PANCREATIC                          | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  M |          |
  CYST                                      |                                   2                                       |          |
  ECTOPIC THYMUS                            |                                  X  X                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          3                                                |          |
PITUITARY GLAND                             | M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  + |          |
  CYTOMEGALY                                |                                2                                          |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   94
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:05.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                      2  2                                 |          |
  HYPERTROPHY,PARS DISTALIS                 |           1                                            2                  |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST,FOLLICLE                             |                                                                           |          |
  ECTOPIC THYMUS                            |                                                                      X    |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             1                                             |          |
  INFLAMMATION                              |                                                                           |          |
  ULTIMOBRANCHIAL CYST                      |  3                       3  2     2     2           2     2     2         |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  M  + |          |
  ATROPHY                                   |  4     3        3  4  3  2  3  3     3     3  4  3  4  4  3  4  4        4|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      2                                    |          |
  INFLAMMATION                              |                                                                           |          |
OVARY                                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |       X     X  X  X  X  X  X  X  X  X  X     X  X  X  X        X  X  X  X |          |
  CONGESTION                                |                                            2                              |          |
  CYST                                      | X              X                       X                 X  X  X          |          |
  CYST,PERIOVARIAN TISSUE                   | X                    X  X     X     X                             X       |          |
  HEMATOCYST                                |          X                                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          2                                                |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                              2            |          |
  ATROPHY                                   |        3                          4                                       |          |
  DILATATION                                |                                   4        4                              |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2        2     2  2  4  3  2  2     2  1  2     1  2     2  3  2  2  2  2|          |
  INFLAMMATION                              |                                                                    2      |          |
VAGINA                                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                   4                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   95
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:05.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |              3                                2                           |          |
  MYELOFIBROSIS                             |                                                              4            |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID,BRONCHIAL            |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMORRHAGE                                |                    2                                                      |          |
  HYPERPLASIA,LYMPHOID                      |                       2           3        2              3           1   |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                     3                     |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HEMORRHAGE                                |                                                                       2   |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
  HYPERPLASIA,RETICULUM CELL                |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
SPLEEN                                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           3                                                               |          |
  CONGESTION                                |                                         2                                 |          |
  HEMATOPOIETIC CELL PROLIFERATION          |           3  3                                                            |          |
  HYPERPLASIA,LYMPHOID                      |                    1  2  1        2  3  4           3                    1|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
THYMUS                                      | M  +  M  +  M  M  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,CORTEX                            |           4        3        3  3  3  2  3  3        3  2  4        4  3  2|          |
  CYST                                      |                                                                           |          |
  ECTOPIC PARATHYROID GLAND                 |                                                                   X       |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                2  4     2           3  2  1              3|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                 2                                                         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                    1      |          |
  LACTATION                                 |                                                                           |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   96
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:05.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                    1  1  1           3              1  1           2      |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                    2  3  1  1  3  2  3  3  1  1     3  2  1  2  2  2  2   |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                     2                     |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,THALAMUS                   |                                                                           |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEVELOPMENTAL MALFORMATION                |                                                          X                |          |
  GLIOSIS                                   |                                                                           |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                    1  1  1  1  1     1  2  2  1  1  2  1     1        1  1|          |
  NECROSIS                                  |                                                                           |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                        1                  |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                                3                                          |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                     2                 2   |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |     2                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1  1  1  1  1     1  1  1  1     1  1     1  1  1  1  2  2  1  1|          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   97
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:05.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1           1  1                    1           1     1   |          |
LACRIMAL GLAND                              | +  +  +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                       2                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2              1  1  1     1        1  1  2     1  1  2           2  1|          |
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |              3                                                            |          |
  HYPERPLASIA,SQUAMOUS                      |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |          |
  CYST,RENAL TUBULE                         |  1                 1                    1        1                 1      |          |
  GLOMERULOSCLEROSIS                        |        3                                                                  |          |
  HYDRONEPHROSIS                            |           2  2                                                            |          |
  HYPERPLASIA,RENAL TUBULE                  |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1        1  1  1  1  1  2  1  1  1  2  2  1     1  1  1  1  1  1  1  1|          |
  MINERALIZATION                            |              2                                                            |          |
  NECROSIS,RENAL TUBULE                     |        3                                                                  |          |
  NEPHROPATHY                               |                                                     1  1  1               |          |
  VACUOLIZATION CYTOPLASMIC,RENAL TUBULE    |              1                                                            |          |
URINARY BLADDER                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROSIS,ADVENTITIA                       |              2                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1           1  1  1  1  1     1  1  1  1  1     1  1  2  2  2  1  1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   98
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +       | 45       |
GALLBLADDER                                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         1                                 |     3 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA,LYMPHOID                      |     3     3                 2     2                       3               |     6 2.5|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA,GOBLET CELL                   |                                                                           |     1 3.0|
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  FIBROSIS                                  |                                                                           |     1 3.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +       | 42       |
  ATROPHY                                   |                                                                           |     1 2.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERPLASIA,LYMPHOID                      |                                      2                                    |     1 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                X                                                          |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |                             1                                             |     5 1.2|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  1  1  1  1  1  1  1              2  1  1  1  1  1  2      |    42 1.2|
  INFLAMMATION                              |                                                                           |     1 1.0|
  NECROSIS                                  |  1  1  1  1  1  1  1     1     1     1  1  1  1  1     1  1  1  1  1      |    27 1.0|
  NECROSIS,COAGULATIVE                      |                                   3                                       |     2 2.0|
  TENSION LIPOIDOSIS                        | X     X     X        X        X  X  X  X     X  X  X                      |    19    |
  VACUOLIZATION CYTOPLASMIC                 |  1  1  1  1  1  2  2  2  1  1  2  2  1  2  1  2  1  1  1  1     1         |    31 1.2|
MESENTERY                                   |                                                 +                         |  2       |
  NECROSIS,FAT                              |                                                  4                        |     2 4.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                                                                           |     2 1.0|
  DEGENERATION                              |                                      1                                    |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1              1     2  1     1  1  1           1  1     2      |    24 1.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1  2  1     1  1  1     1  2  1  2  1  2  1  2  1  2  1  2  2  1      |    41 1.4|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   99
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  HYPERKERATOSIS                            |                                                        2                  |     1 2.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CYST                                      |                                2  2                                1      |     5 1.6|
  HYPERPLASIA                               |        1                                                                  |     2 1.5|
  MINERALIZATION                            |                                                                           |     1 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,MAST CELL           |                                                           2               |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CARDIOMYOPATHY                            |                                                        1                  |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  THROMBUS                                  |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                          X                |     1    |
ADRENAL GLAND,CORTEX                        | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HEMATOPOIETIC CELL PROLIFERATION          |                             1                                             |     1 1.0|
  HYPERPLASIA,SPINDLE CELL                  |     2  2  2  3  2  2  1  3     2  2  3  1  2  1  2  2  3  1  2  2  1      |    44 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                  2                        |     1 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 2.0|
ADRENAL GLAND,MEDULLA                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFLAMMATION                              |                                                                           |     1 3.0|
  VACUOLIZATION CYTOPLASMIC                 |                                                                    2      |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
PARATHYROID GLAND                           | +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +       | 38       |
  CYST                                      |                                                                           |     1 2.0|
  ECTOPIC THYMUS                            |                                                                           |     2    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 3.0|
PITUITARY GLAND                             | +  +  +  +  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 40       |
  CYTOMEGALY                                |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  100
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                        2                  |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |  2                                                                        |     3 2.0|
  HYPERTROPHY,PARS DISTALIS                 |                                                                           |     2 1.5|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CYST,FOLLICLE                             |                                      2                                    |     1 2.0|
  ECTOPIC THYMUS                            |                                                                           |     1    |
  HYPERPLASIA,FOLLICULAR CELL               |                                         2                                 |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     2 1.0|
  INFLAMMATION                              |              1                                                            |     1 1.0|
  ULTIMOBRANCHIAL CYST                      |                    2  2  2     3  2        2  2  3     2        4  2      |    19 2.3|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M       | 38       |
  ATROPHY                                   |  3  4  3  4     4  4     3  4  3  3  4  2  3  4  3  3  3  3     4         |    37 3.3|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
  INFLAMMATION                              |                                1                                          |     1 1.0|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ANGIECTASIS                               |                                   2                                       |     1 2.0|
  ATROPHY                                   | X     X  X  X  X  X        X  X  X  X  X  X  X  X  X     X  X  X          |    37    |
  CONGESTION                                |                                                                           |     1 2.0|
  CYST                                      |                      X  X                          X                      |     9    |
  CYST,PERIOVARIAN TISSUE                   |    X                                            X     X     X             |    10    |
  HEMATOCYST                                |                               X                    X              X       |     4    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 2                                                         |     2 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |                                                                           |     1 2.0|
  ATROPHY                                   |                                                                           |     2 3.5|
  DILATATION                                |                                   3  3                                    |     4 3.5|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  1  2  2  2  2  2  3  2  3  2  2     2  1  2  3  3  3  3  2  3  2         |    40 2.1|
  INFLAMMATION                              |                                                                           |     1 2.0|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                         2                                 |     2 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  101
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA                               |                             3                                             |     3 2.6|
  MYELOFIBROSIS                             |                                                                           |     1 4.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA,LYMPHOID,BRONCHIAL            |                                                                 2         |     1 2.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |  3                       3                                2               |     8 2.3|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                                                           |     1 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                             1                                             |     1 1.0|
  HEMORRHAGE                                |                                                           2               |     2 2.0|
  HYPERPLASIA,LYMPHOID                      |                                   2     2                                 |     2 2.0|
  HYPERPLASIA,RETICULUM CELL                |     3                                                                     |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                  3                        |     1 3.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                                                           |     1 3.0|
  CONGESTION                                |              1                                               1            |     3 1.3|
  HEMATOPOIETIC CELL PROLIFERATION          |                       3     4                                             |     4 3.2|
  HYPERPLASIA,LYMPHOID                      |  4  3     3     2        2     2  2     1  1  3     2           3  2      |    21 2.2|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                     3                     |     1 3.0|
THYMUS                                      | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M       | 38       |
  ATROPHY,CORTEX                            |     3     2        2  2  2  4           3  3  4  2  2     2  3            |    27 2.8|
  CYST                                      |                                                  2                        |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |  3                    2  2        3     1  3  1        2  1               |    16 2.1|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  LACTATION                                 |  1                                                                        |     1 1.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          2                                                |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  102
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FIBROUS OSTEODYSTROPHY                    |                             1           2     1  1     2     1            |    13 1.3|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  1  2  2  2  2  3  2        1        2  3  3  1  2  3  2  2  3  2  1      |    36 2.0|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     2 1.5|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  MINERALIZATION,THALAMUS                   |                                                     1                     |     1 1.0|
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEVELOPMENTAL MALFORMATION                |                                                                           |     1    |
  GLIOSIS                                   |                                                                 2         |     1 2.0|
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1  1     1  1     1  1           1  2  1     1  1  1  2  1     1  1      |    31 1.1|
  NECROSIS                                  |                                                                 2         |     1 2.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CONGESTION                                |                                                                           |     1 3.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |     2 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                     1                     |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2     1     1  1  1        1  2  2  2  1  1  1  2  1  2  2  2  2  2      |    40 1.3|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  103
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1              1  1     1  1                          1     1  2         |    14 1.0|
LACRIMAL GLAND                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +       | 41       |
  ATROPHY                                   |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1        1     1  2  2     1  1     2  1              1      |    25 1.2|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |                                                                           |     1 3.0|
  HYPERPLASIA,SQUAMOUS                      |              2                                                            |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                4                    4                     |     2 4.0|
  CYST,RENAL TUBULE                         |              1        1  1                    1           1               |    10 1.0|
  GLOMERULOSCLEROSIS                        |                             2                                             |     2 2.5|
  HYDRONEPHROSIS                            |                                                                           |     2 2.0|
  HYPERPLASIA,RENAL TUBULE                  |                          1                                                |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  2  2  1  1  2  1        1  1  1  1  1  1  1  1  1     2  2  1      |    42 1.2|
  MINERALIZATION                            |                                                                           |     1 2.0|
  NECROSIS,RENAL TUBULE                     |                                                                           |     1 3.0|
  NEPHROPATHY                               |                                                  1  2  1           1      |     7 1.1|
  VACUOLIZATION CYTOPLASMIC,RENAL TUBULE    |                                                                           |     1 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROSIS,ADVENTITIA                       |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  2  1  1  1  1  2  2  2  1  1  1     1  2  2  1     1      |    41 1.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  104
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +                                                       |          |
  HYPERKERATOSIS                            |  2                                                                        |          |
GALLBLADDER                                 | +  +  +  +  +  +  +                                                       |          |
INTESTINE LARGE                             | A  +  +  +  +  +  +                                                       |          |
INTESTINE LARGE,CECUM                       | A  +  A  +  +  +  +                                                       |          |
  HYPERPLASIA,LYMPHOID                      |              2                                                            |          |
INTESTINE LARGE,COLON                       | A  +  +  +  +  +  +                                                       |          |
INTESTINE LARGE,RECTUM                      | A  +  +  +  +  +  +                                                       |          |
INTESTINE SMALL                             | A  +  A  +  +  +  +                    +  +                               |          |
INTESTINE SMALL,DUODENUM                    | A  +  A  +  +  +  +                    +                                  |          |
INTESTINE SMALL,ILEUM                       | A  +  A  +  +  +  +                                                       |          |
  HYPERPLASIA,LYMPHOID                      |                    2                                                      |          |
INTESTINE SMALL,JEJUNUM                     | A  +  A  +  +  +  +                       +                               |          |
  HYPERPLASIA,LYMPHOID                      |                    2                                                      |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  CYST,BILE DUCT                            |                                                                           |          |
  DEGENERATION                              |                    1                                                      |          |
  DEGENERATION,FATTY                        |                                         2                                 |          |
  EOSINOPHILIC FOCUS                        |                                                    X                      |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     2  1     2     1        1                 1                          3|          |
  HYPERPLASIA,KUPFFER CELL                  |              3     2                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1  1  2  1  1  1  1     2        1  1  2  1  1  1  1  1      |          |
  INFILTRATION CELLULAR,PLASMA CELL         |              1                                                            |          |
  NECROSIS                                  |              1  1     2  1  1  1  2     1           2  1  1  1  1     1   |          |
  NECROSIS,COAGULATIVE                      |                                                                    1      |          |
  REGENERATION                              |                                         2                                 |          |
  TENSION LIPOIDOSIS                        |                         X        X              X  X        X  X  X       |          |
  VACUOLIZATION CYTOPLASMIC                 |     1           2  1  1  2  2  1  2        2     2  2  2  1  2  1  1  1  1|          |
MESENTERY                                   |                               +        +                 +        +       |          |
  NECROSIS,FAT                              |                                4        4                 4               |          |
PANCREAS                                    | A  +  +  +  +  +  +                    +                                  |          |
  CYST,DUCT                                 |                                         4                                 |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1  1  1                                                      |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +                                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2  1  1  1  2                                                      |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  105
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

STOMACH                                     | A  +  +  +  +  +  +                                                       |          |
STOMACH,FORESTOMACH                         | A  +  +  +  +  +  +                                                       |          |
STOMACH,GLANDULAR                           | A  +  +  +  +  +  +                                                       |          |
  CYST                                      |                 1                                                         |          |
TONGUE                                      | +  +  +  +  +  +  +                                                       |          |
  MINERALIZATION                            |              2                                                            |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  M  +  +  +  +  +                                                       |          |
BLOOD VESSEL,AORTA                          | +  M  +  +  +  +  +                                                       |          |
HEART                                       | +  +  +  +  +  +  +                                                       |          |
  HYPERPLASIA,EPICARDIUM                    |     2                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +                          +                            |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +                                                       |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  2  2     1                                                      |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +                                                       |          |
ISLETS, PANCREATIC                          | A  +  +  +  +  +  +                                                       |          |
PARATHYROID GLAND                           | +  +  +  +  +  +  +                                                       |          |
PITUITARY GLAND                             | A  +  +  +  M  +  M                                                       |          |
THYROID GLAND                               | +  +  +  +  +  +  +                                                       |          |
  ULTIMOBRANCHIAL CYST                      |              3     2                                                      |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +                                                       |          |
  ATROPHY                                   |  3  3  3  3  2  2  4                                                      |          |
OVARY                                       | +  +  +  +  +  +  +  +     +  +           +  +                    +  +    |          |
  ATROPHY                                   |    X  X  X  X     X                                                       |          |
  CYST                                      |    X        X        X        X              X                            |          |
  CYST,PERIOVARIAN TISSUE                   |                            X                                         X    |          |
UTERUS                                      | +  +  +  +  +  +  +           +  +                 +     +  +  +     +  + |          |
  ATROPHY                                   |     3  4  4  2                                                            |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  106
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  DILATATION                                |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |                    1           3  2                       1  3  3     4  2|          |
VAGINA                                      | +  +  +  +  +  +  +                                                       |          |
  ATROPHY                                   |     3  3  4  4                                                            |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +                                                       |          |
  DEPLETION                                 |              2                                                            |          |
  HYPERPLASIA                               |                    3                                                      |          |
  MYELOFIBROSIS                             |     2                                                                     |          |
LYMPH NODE                                  | +  +  +  +  +  +  +                                               +     + |          |
  HYPERPLASIA,LYMPHOID,INGUINAL             |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +                                                       |          |
  HEMATOPOIETIC CELL PROLIFERATION          |           3                                                               |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  M  +  +                                               +       |          |
  ATROPHY                                   |        2  4                                                               |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                    3                                                      |          |
  HEMORRHAGE                                |                    3                                                      |          |
SPLEEN                                      | +  +  +  +  +  +  +        +              +     +     +     +  +        + |          |
  ATROPHY                                   |        3     3                                                            |          |
  CONGESTION                                |        1                                                                  |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  3     2     4                                                            |          |
  HYPERPLASIA,LYMPHOID                      |                 1                                      2                  |          |
THYMUS                                      | +  +  +  M  M  +  +                                                       |          |
  ATROPHY,CORTEX                            |                    3                                                      |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | A  +  +  M  +  +  +                                                       |          |
  HYPERPLASIA                               |        3                                                                  |          |
SKIN                                        | A  +  +  +  +  +  +                          +                            |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  107
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +                                                       |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +                                                       |          |
BONE,STERNUM                                | +  +  +  +  +  +  +                                                       |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |        2           2                                                      |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +                                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +                                                       |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +                                                       |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +                                                       |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     1  1     1     1                                                      |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +                                                       |          |
SPINAL CORD                                 | +  +  +  +  +  +  +                                                       |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +                                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  M  M  +  M  M  +                                                       |          |
LUNG                                        | +  +  +  +  +  +  +                                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 2  1                                                      |          |
NOSE                                        | +  +  +  +  +  +  +                                                       |          |
TRACHEA                                     | +  +  +  +  +  +  +                                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  A  A  +  +  +                                                       |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +                                                     + |          |
  HYPERPLASIA                               |              4                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                                  |          |
LACRIMAL GLAND                              | +  M  M  M  +  +  +                                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1  1                                                      |          |
ZYMBAL'S GLAND                              | M  +  +  +  +  +  +                                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  108
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +                                                       |          |
  ACCUMULATION HYALINE DROPLET              |        4                                                                  |          |
  CYST,RENAL TUBULE                         |        1                                                                  |          |
  GLOMERULOSCLEROSIS                        |        3     3                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1        2  1  2                                                      |          |
URETER                                      |                                                                           |          |
URINARY BLADDER                             | +  +  +  +  +  +  +                                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1  1  1                                                      |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  109
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   |                                              M                            |  7       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
GALLBLADDER                                 |                                              +                            |  8       |
INTESTINE LARGE                             |                                              +                            |  7       |
INTESTINE LARGE,CECUM                       |                                              +                            |  6       |
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
INTESTINE LARGE,COLON                       |                                              +                            |  7       |
INTESTINE LARGE,RECTUM                      |                                              +                            |  7       |
INTESTINE SMALL                             |                                              +                            |  8       |
INTESTINE SMALL,DUODENUM                    |                                              +                            |  7       |
INTESTINE SMALL,ILEUM                       |                                              +                            |  6       |
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
INTESTINE SMALL,JEJUNUM                     |                                              +                            |  7       |
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |    X                                                                      |     1    |
  CYST,BILE DUCT                            |                                                                    2      |     1 2.0|
  DEGENERATION                              |                                                                           |     1 1.0|
  DEGENERATION,FATTY                        |                                                                           |     1 2.0|
  EOSINOPHILIC FOCUS                        |                         X                                                 |     2    |
  HEMATOPOIETIC CELL PROLIFERATION          |           1  1                    1        1     1                 1      |    13 1.3|
  HYPERPLASIA,KUPFFER CELL                  |                                                                           |     2 2.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1     1  1  1  1  1  1  1  1  1     1  1        2     1  1  2  1      |    35 1.1|
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |     1 1.0|
  NECROSIS                                  |  1  1  1  1  2     1     1  1  1  1  1  1  1     1  1  1  1  1     1      |    33 1.1|
  NECROSIS,COAGULATIVE                      |                                                                           |     1 1.0|
  REGENERATION                              |                                                                           |     1 2.0|
  TENSION LIPOIDOSIS                        |          X           X  X           X                    X  X  X          |    14    |
  VACUOLIZATION CYTOPLASMIC                 |  2  1  1  2  1  2  2  2     2  2  1  1  1  2     2     2  2     1         |    36 1.5|
MESENTERY                                   |                                                                           |  4       |
  NECROSIS,FAT                              |                                                                           |     3 4.0|
PANCREAS                                    |                                              +                            |  8       |
  CYST,DUCT                                 |                                                                           |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     5 1.0|
SALIVARY GLANDS                             |                                              +  +                         |  9       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     5 1.4|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  110
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

STOMACH                                     |                                              +                            |  7       |
STOMACH,FORESTOMACH                         |                                              +                            |  7       |
STOMACH,GLANDULAR                           |                                              +                            |  7       |
  CYST                                      |                                                                           |     1 1.0|
TONGUE                                      |                                              +                            |  8       |
  MINERALIZATION                            |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                |                                              +                            |  7       |
BLOOD VESSEL,AORTA                          |                                              +                            |  7       |
HEART                                       |                                              +                            |  8       |
  HYPERPLASIA,EPICARDIUM                    |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               |                                              +                            |  9       |
ADRENAL GLAND,CORTEX                        |                                              +                            |  8       |
  HYPERPLASIA,SPINDLE CELL                  |                                                                           |     4 1.7|
ADRENAL GLAND,MEDULLA                       |                                              +                            |  8       |
ISLETS, PANCREATIC                          |                                              +                            |  7       |
PARATHYROID GLAND                           |                                              M                            |  7       |
PITUITARY GLAND                             |                                              M                            |  4       |
THYROID GLAND                               |                                              +                            |  8       |
  ULTIMOBRANCHIAL CYST                      |                                                                           |     2 2.5|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              |                                              +                            |  8       |
  ATROPHY                                   |                                               3                           |     8 2.8|
OVARY                                       | +  +  +        +     +     +  +     +  +  +  +  +     +     +             | 28       |
  ATROPHY                                   |                                              X                            |     6    |
  CYST                                      |                X           X  X     X     X           X                   |    11    |
  CYST,PERIOVARIAN TISSUE                   | X  X  X              X                 X        X           X             |     9    |
UTERUS                                      | +  +           +  +     +  +  +  +        +  +  +           +  +  +       | 29       |
  ATROPHY                                   |                                               4                           |     5 3.4|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  111
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  DILATATION                                |                 4              3                                          |     2 3.5|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2  3              2     4  2     2        2     3           2  2  2      |    19 2.3|
VAGINA                                      |                                              +                            |  8       |
  ATROPHY                                   |                                               4                           |     5 3.6|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 |                                              +                            |  8       |
  DEPLETION                                 |                                                                           |     1 2.0|
  HYPERPLASIA                               |                                                                           |     1 3.0|
  MYELOFIBROSIS                             |                                                                           |     1 2.0|
LYMPH NODE                                  |             +                    +  +        +  +     +                   | 15       |
  HYPERPLASIA,LYMPHOID,INGUINAL             |                                      2                                    |     1 2.0|
LYMPH NODE,MANDIBULAR                       |             +                                +                            |  9       |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       |                                  +           +  +     +                   | 11       |
  ATROPHY                                   |                                                                           |     2 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     1 3.0|
  HEMORRHAGE                                |                                                                           |     1 3.0|
SPLEEN                                      |             +           +     +  +           +  +                         | 20       |
  ATROPHY                                   |                                                                           |     2 3.0|
  CONGESTION                                |                          2                                                |     2 1.5|
  HEMATOPOIETIC CELL PROLIFERATION          |              3                                                            |     4 3.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     2 1.5|
THYMUS                                      |                                              +                            |  6       |
  ATROPHY,CORTEX                            |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               |                                              +                            |  6       |
  HYPERPLASIA                               |                                                                           |     1 3.0|
SKIN                                        |                                              +                            |  8       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  112
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE                                        |                                              +                            |  8       |
BONE,FEMUR                                  |                                              +                            |  8       |
BONE,STERNUM                                |                                              +                            |  8       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                                                                           |     2 2.0|
SKELETAL MUSCLE                             |                                              +                            |  8       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       |                                              +                            |  8       |
BRAIN,CEREBELLUM                            |                                              +                            |  8       |
BRAIN,CEREBRUM                              |                                              +                            |  8       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                                                                           |     4 1.0|
PERIPHERAL NERVE                            |                                              +                            |  8       |
SPINAL CORD                                 |                                              +                            |  8       |
SPINAL CORD,THORACIC                        |                                              +                            |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      |                                              +                            |  4       |
LUNG                                        |                                              +                            |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.5|
NOSE                                        |                                              +                            |  8       |
TRACHEA                                     |                                              +                            |  8       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         |                                              +                            |  5       |
HARDERIAN GLAND                             |                +                             +                            | 10       |
  HYPERPLASIA                               |                                                                           |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     2 1.0|
LACRIMAL GLAND                              |                                              +                            |  5       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     3 1.0|
ZYMBAL'S GLAND                              |                                              M                            |  6       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  113
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      |                                  +           +                            |  9       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     1 4.0|
  CYST,RENAL TUBULE                         |                                                                           |     1 1.0|
  GLOMERULOSCLEROSIS                        |                                                                           |     2 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     4 1.5|
URETER                                      |                                                 +                         |  1       |
URINARY BLADDER                             |                                              +                            |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     5 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  114
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:28.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|   S  R   R|
                                            | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7|   U  V   I|
25MG   FS-2YR 13    13                      | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  M                                                                   |          |
GALLBLADDER                                 | +  +  +                                                                   |          |
INTESTINE LARGE                             | +  +  +                                                                   |          |
INTESTINE LARGE,CECUM                       | +  A  A                                                                   |          |
INTESTINE LARGE,COLON                       | +  A  +                                                                   |          |
INTESTINE LARGE,RECTUM                      | +  +  M                                                                   |          |
INTESTINE SMALL                             | +  A  A                                                                   |          |
INTESTINE SMALL,DUODENUM                    | +  A  A                                                                   |          |
INTESTINE SMALL,ILEUM                       | +  A  A                                                                   |          |
INTESTINE SMALL,JEJUNUM                     | +  A  A                                                                   |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |        3                                                                  |          |
  BASOPHILIC FOCUS                          |                                                       X                   |          |
  DEGENERATION                              |                    3                                                      |          |
  EOSINOPHILIC FOCUS                        |                            X                                              |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                     1        1  1  1      |          |
  HYPERPLASIA,OVAL CELL                     |                    1                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2     2  1        2  1           3  1  1  1  1        2     1  1  1  1|          |
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |          |
  NECROSIS                                  |     1        1  1  1  2  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1|          |
  NECROSIS,COAGULATIVE                      |        3           3                             1                        |          |
  REGENERATION                              |                    3                                                      |          |
  TENSION LIPOIDOSIS                        |             X           X     X  X              X  X        X        X  X |          |
  THROMBUS                                  |        3                                                                  |          |
  VACUOLIZATION CYTOPLASMIC                 |                 3  2  2  3  3  3  2  1  2  3  2  2  1  2  2  2  2  2  2  2|          |
MESENTERY                                   |                                                                           |          |
PANCREAS                                    | +  +  A                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |          |
SALIVARY GLANDS                             | +  +  +                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2                                                                  |          |
STOMACH                                     | +  A  +                                                                   |          |
STOMACH,FORESTOMACH                         | +  A  +                                                                   |          |
  HYPERKERATOSIS                            |  2                                                                        |          |
STOMACH,GLANDULAR                           | +  A  +                                                                   |          |
TONGUE                                      | +  +  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  115
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:29.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|   S  R   R|
                                            | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7|   U  V   I|
25MG   FS-2YR 13    13                      | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +                                                                   |          |
BLOOD VESSEL,AORTA                          | +  +  +                                                                   |          |
HEART                                       | +  +  +                                                                   |          |
  NECROSIS                                  |        1                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  M                                                                   |          |
ADRENAL GLAND,CORTEX                        | +  +  M                                                                   |          |
  HYPERPLASIA,SPINDLE CELL                  |  1                                                                        |          |
ADRENAL GLAND,MEDULLA                       | +  +  M                                                                   |          |
ISLETS, PANCREATIC                          | +  +  A                    +                                              |          |
PARATHYROID GLAND                           | M  M  M                                                                   |          |
PITUITARY GLAND                             | M  M  M                                                                   |          |
THYROID GLAND                               | +  +  M                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  M  M                                                                   |          |
  ATROPHY                                   |  4                                                                        |          |
OVARY                                       | +  +  M  +  +  +  +     +  +     +        +  +     +     +  +     +     + |          |
  ATROPHY                                   |    X                                                                      |          |
  CYST                                      |          X        X     X        X        X        X              X     X |          |
  CYST,PERIOVARIAN TISSUE                   |             X  X           X                 X           X  X             |          |
  HEMATOCYST                                |                                                                           |          |
UTERUS                                      | +  +  +     +     +  +           +     +  +     +  +     +     +  +  +    |          |
  ATROPHY                                   |  4     4                                                                  |          |
  DILATATION                                |  2                 4                                      4           2   |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              3                    3     2  2     2  3           3  2      |          |
  INFLAMMATION                              |                                                                           |          |
VAGINA                                      | +  M  M                                                                   |          |
  ATROPHY                                   |  4                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  116
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:29.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|   S  R   R|
                                            | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7|   U  V   I|
25MG   FS-2YR 13    13                      | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  A  A                                                                   |          |
LYMPH NODE                                  | +  +  +              +                                +                   |          |
LYMPH NODE,MANDIBULAR                       | +  +  +                                                                   |          |
LYMPH NODE,MESENTERIC                       | +  +  M                                               +                   |          |
SPLEEN                                      | +  +  +                    +                    +     +                   |          |
  ATROPHY                                   |        2                                                                  |          |
  CONGESTION                                |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |        3                                                                  |          |
  HYPERPLASIA,LYMPHOID                      |                             3                                             |          |
THYMUS                                      | +  +  M                                         +                         |          |
  ATROPHY,CORTEX                            |     2                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  M                                                                   |          |
SKIN                                        | +  +  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +                                                                   |          |
BONE,FEMUR                                  | +  M  +                                                                   |          |
BONE,STERNUM                                | +  +  +                                                                   |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |     3                                                                     |          |
SKELETAL MUSCLE                             | +  +  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +                                                                   |          |
BRAIN,CEREBELLUM                            | +  +  +                                                                   |          |
BRAIN,CEREBRUM                              | +  +  +                                                                   |          |
PERIPHERAL NERVE                            | +  +  +                                                                   |          |
SPINAL CORD                                 | +  +  +                                                                   |          |
SPINAL CORD,THORACIC                        | +  +  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  117
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:29.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|   S  R   R|
                                            | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7|   U  V   I|
25MG   FS-2YR 13    13                      | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M                                                                   |          |
LUNG                                        | +  +  +                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2  1                                                                  |          |
NOSE                                        | +  +  +                                                                   |          |
TRACHEA                                     | +  +  M                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  A  A                                                                   |          |
HARDERIAN GLAND                             | +  +  +                                         +                         |          |
  HYPERPLASIA                               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1                                                                  |          |
LACRIMAL GLAND                              | +  +  M                                                                   |          |
ZYMBAL'S GLAND                              | M  M  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1                                                                  |          |
URINARY BLADDER                             | +  +  M                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  118
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:30.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
25MG   FS-2YR 13    13                      | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   |                                                                           |  2       |
GALLBLADDER                                 |                                                                           |  3       |
INTESTINE LARGE                             |                                                                           |  3       |
INTESTINE LARGE,CECUM                       |                                                                           |  1       |
INTESTINE LARGE,COLON                       |                                                                           |  2       |
INTESTINE LARGE,RECTUM                      |                                                                           |  2       |
INTESTINE SMALL                             |                               +                                           |  2       |
INTESTINE SMALL,DUODENUM                    |                                                                           |  1       |
INTESTINE SMALL,ILEUM                       |                                                                           |  1       |
INTESTINE SMALL,JEJUNUM                     |                               +                                           |  2       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |                                                                           |     1 3.0|
  BASOPHILIC FOCUS                          |                                              X                            |     2    |
  DEGENERATION                              |                                                                           |     1 3.0|
  EOSINOPHILIC FOCUS                        |                                                                           |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |  1  1           1  1  1              1        1                 1  1      |    13 1.0|
  HYPERPLASIA,OVAL CELL                     |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  1  1  1  1  1  1  2  1  2  1  1  1  1  1  1  1  1  2      |    36 1.2|
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                 1         |     1 1.0|
  NECROSIS                                  |  1  1  1  1  1     1  1  1  1  1  1     1  1     1  2  1  1     1         |    40 1.0|
  NECROSIS,COAGULATIVE                      |        2                                                                  |     4 2.2|
  REGENERATION                              |                                                                           |     1 3.0|
  TENSION LIPOIDOSIS                        |    X     X  X  X                    X     X  X  X  X  X     X             |    20    |
  THROMBUS                                  |                                                                           |     1 3.0|
  VACUOLIZATION CYTOPLASMIC                 |  2  1  1  1  2  2  1  1  2  2  1  1  2  2  1  2  2  3  2  2  1     2      |    42 1.8|
MESENTERY                                   |                   +                                                       |  1       |
PANCREAS                                    |                                                                           |  2       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
SALIVARY GLANDS                             |                                                                           |  3       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     3 1.3|
STOMACH                                     |                                                                           |  2       |
STOMACH,FORESTOMACH                         |                                                                           |  2       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
STOMACH,GLANDULAR                           |                                                                           |  2       |
TONGUE                                      |                                                                           |  3       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  119
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:30.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
25MG   FS-2YR 13    13                      | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                |                                                                           |  3       |
BLOOD VESSEL,AORTA                          |                                                                           |  3       |
HEART                                       |                                                                           |  3       |
  NECROSIS                                  |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               |                                                                           |  2       |
ADRENAL GLAND,CORTEX                        |                                                                           |  2       |
  HYPERPLASIA,SPINDLE CELL                  |                                                                           |     1 1.0|
ADRENAL GLAND,MEDULLA                       |                                                                           |  2       |
ISLETS, PANCREATIC                          |                                                                           |  3       |
PARATHYROID GLAND                           |                                                                           |  0       |
PITUITARY GLAND                             |                                                                           |  0       |
THYROID GLAND                               |                                                                           |  2       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              |                                                                           |  1       |
  ATROPHY                                   |                                                                           |     1 4.0|
OVARY                                       | +  +  +  +  +        +  +     +              +           +  +  +          | 28       |
  ATROPHY                                   |                                                                           |     1    |
  CYST                                      |       X  X  X        X        X              X           X  X  X          |    17    |
  CYST,PERIOVARIAN TISSUE                   | X                                                                         |     7    |
  HEMATOCYST                                |                         X                                                 |     1    |
UTERUS                                      | +  +  +        +     +        +  +     +        +  +  +  +  +             | 28       |
  ATROPHY                                   |                                                                           |     2 4.0|
  DILATATION                                |     3           4     3                                2                  |     8 3.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2     3                       2  4     2        2  4     2  2            |    17 2.5|
  INFLAMMATION                              |                 2                                                         |     1 2.0|
VAGINA                                      |                                                                           |  1       |
  ATROPHY                                   |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  120
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:30.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
25MG   FS-2YR 13    13                      | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 |                                                                           |  1       |
LYMPH NODE                                  |                +                                                          |  6       |
LYMPH NODE,MANDIBULAR                       |                +                                                          |  4       |
LYMPH NODE,MESENTERIC                       |                +                                                          |  4       |
SPLEEN                                      | +        +  +  +  +  +              +                          +  +       | 15       |
  ATROPHY                                   |                                                                           |     1 2.0|
  CONGESTION                                |           1                                                               |     1 1.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                 4         |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |              2        1              3                                    |     4 2.2|
THYMUS                                      |                +                                                          |  4       |
  ATROPHY,CORTEX                            |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               |                                                                           |  2       |
SKIN                                        | +                 +                                            +          |  6       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        |                                                                           |  3       |
BONE,FEMUR                                  |                                                                           |  2       |
BONE,STERNUM                                |                                                                           |  3       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                                                                           |     1 3.0|
SKELETAL MUSCLE                             |                                                                           |  3       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       |                                                                           |  3       |
BRAIN,CEREBELLUM                            |                                                                           |  3       |
BRAIN,CEREBRUM                              |                                                                           |  3       |
PERIPHERAL NERVE                            |                                                                           |  3       |
SPINAL CORD                                 |                                                                           |  3       |
SPINAL CORD,THORACIC                        |                                                                           |  3       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  121
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:30.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
25MG   FS-2YR 13    13                      | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

LARYNX                                      |                                                                           |  2       |
LUNG                                        |          +                                                                |  4       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.5|
NOSE                                        |                                                                           |  3       |
TRACHEA                                     |                                                                           |  2       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         |                                                                           |  0       |
HARDERIAN GLAND                             |       +                                                                   |  5       |
  HYPERPLASIA                               |        4                                                                  |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.0|
LACRIMAL GLAND                              |                                                                           |  2       |
ZYMBAL'S GLAND                              |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      |                                                                           |  3       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.0|
URINARY BLADDER                             |                                                                           |  2       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  122
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |     2                                                                     |          |
GALLBLADDER                                 | M  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET              |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
INTESTINE LARGE                             | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,COLON                       | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,GOBLET CELL                   |                       2                                                   |          |
INTESTINE LARGE,RECTUM                      | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL                             | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | A  +  +  A  M  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,ILEUM                       | A  +  +  A  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                          1                                   2            |          |
INTESTINE SMALL,JEJUNUM                     | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  DEGENERATION                              |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     2           1                                                        1|          |
  HYPERPLASIA,KUPFFER CELL                  |              3                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1     3     1  1  1  1  2  1     1  2  2     1  1  1  1  1|          |
  INFLAMMATION                              |                                            1                              |          |
  NECROSIS                                  |        1     1        1  1  1  1  1  1     1     1  1  1  1  1  3     1  1|          |
  NECROSIS,COAGULATIVE                      |              1                                                            |          |
  TENSION LIPOIDOSIS                        |                         X     X                       X  X     X  X  X    |          |
  THROMBUS                                  |              1                                                            |          |
  VACUOLIZATION CYTOPLASMIC                 |     1  4  4                    2  1  2  1           2     2  2  1  2  2  2|          |
PANCREAS                                    | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET,DUCT         |                                                                           |          |
  DEGENERATION                              |     1                                                                     |          |
  FOCAL CELLULAR CHANGE                     |              1                                                            |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |     2                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1  1        2     1           1  2     1  1     2           1   |          |
  NECROSIS                                  |     1                                                                     |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  123
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |  2                                                              2         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2  1  1  2  1  2  1  1  1  1     2  2     2  1  1  1  1  2  1  1  2|          |
STOMACH                                     | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |        2                                                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |                                                                           |          |
STOMACH,GLANDULAR                           | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |                                                                           |          |
  MINERALIZATION                            |                                      1                                    |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  POLYARTERITIS                             |                                                                 2         |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  + |          |
BLOOD VESSEL,AORTA                          | +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,VALVE                        |                                                                       1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1                                                |          |
  NECROSIS                                  |           2                                                               |          |
  POLYARTERITIS                             |                                                                 2         |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  2  2  1     2  1  1  2  2  2  2  1     2  2  1  2  2  2     1   |          |
  VACUOLIZATION CYTOPLASMIC                 |                                      2                 1                  |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  + |          |
ISLETS, PANCREATIC                          | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                        2                  |          |
PARATHYROID GLAND                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M |          |
  ECTOPIC THYMUS                            |                                                 X                         |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  124
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                  1                        |          |
PITUITARY GLAND                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |              3     3  1                                   2        2  1   |          |
  POLYARTERITIS                             |                                                                 2         |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |                       2                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            1                              |          |
  POLYARTERITIS                             |                                                                 2         |          |
  ULTIMOBRANCHIAL CYST                      |        2     2        3  2        3  3     2           3     2        2   |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  M  +  +  M  +  +  M  M  +  M  M  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |     4  3  3        4  2     2  3        2           4  1  3  3     3  2  3|          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |    X  X  X  X     X        X  X  X  X  X  X     X  X  X     X  X  X  X    |          |
  CYST                                      |                      X     X        X     X           X                   |          |
  CYST,PERIOVARIAN TISSUE                   |                X                                                          |          |
  HEMATOCYST                                |                                                                      X    |          |
  MINERALIZATION                            |                                                                           |          |
UTERUS                                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |  4                                   3        4                    3      |          |
  DILATATION                                |                    4              4                                       |          |
  FIBROSIS                                  |              3                                                            |          |
  HEMORRHAGE                                |              4                                                            |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2  2     2  1  1  3        4  4     2  2  2  3  2  2     1  2|          |
  INFLAMMATION                              |                                                                           |          |
VAGINA                                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  + |          |
  ATROPHY                                   |                    4                          4                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
  POLYARTERITIS                             |                                                                 3         |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  125
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |     4                                                                     |          |
  INFARCT                                   |                                                                           |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                  2                        |          |
  HYPERPLASIA,LYMPHOID                      |                 2                                                         |          |
LYMPH NODE,MESENTERIC                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ATROPHY                                   |                                                        1                  |          |
  HEMORRHAGE                                |              2                                                            |          |
  HYPERPLASIA,LYMPHOID                      |                 2                                                         |          |
SPLEEN                                      | A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |              3                                                            |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     4        4        2           2        2           2                  |          |
  HYPERPLASIA,LYMPHOID                      |        3        2           2  1  1                 3     3  2     2      |          |
  INFARCT                                   |                                      1                                    |          |
THYMUS                                      | M  +  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  + |          |
  ATROPHY,CORTEX                            |     2  3     4  4     3           2        3     4  3     2  2     3     3|          |
  CONGESTION                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |     2  2                    2        1     2           1  2  2     2     3|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |              2                                                            |          |
  LACTATION                                 |              3                                                            |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,TURBINATE          |                                                        1              1   |          |
BONE,FEMUR                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                          1           1  1              1        2        1|          |
BONE,STERNUM                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  126
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                          1  1  2     2  3  2        2  1  1  2  2     1  2|          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1  1  1  1  1  1  1  1        1  2  1  2        1  1  2     1  1   |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  + |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |           4                                                               |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                          1  1                                             |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1  1     1  1  2  1  1  1  2  1     1  1  1  2  1  1     1  1|          |
  INFLAMMATION                              |     1                                                                     |          |
NOSE                                        | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FOCAL CELLULAR CHANGE                     |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION,CORNEA                       |                                                                           |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                 1     2  1              1           1        1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  127
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:46.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

LACRIMAL GLAND                              | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     2  1     2     2     1  1        1  2     2  1  1        2        2|          |
ZYMBAL'S GLAND                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                            2                              |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET              |     3                                                                     |          |
  CYST,RENAL TUBULE                         |                    1     1                                                |          |
  GLOMERULOSCLEROSIS                        |                                                                           |          |
  HYDRONEPHROSIS                            |     1                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1  1  1  1  1  1     1  1  1  3  1  1     1  1  1  1     1  1  1  1|          |
  MINERALIZATION                            |        1                                                                  |          |
  NEPHROPATHY                               |                                                                           |          |
  PIGMENTATION,RENAL TUBULE                 |  3                                                                        |          |
URINARY BLADDER                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2        1     2  1  1  1  1  1  1  1     1  2  1  1  1  2        1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  128
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:58.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +       | 44       |
  ACCUMULATION HYALINE DROPLET              |                                         2                                 |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     2 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE LARGE,CECUM                       | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,LYMPHOID                      |                                1                                          |     1 1.0|
INTESTINE LARGE,COLON                       | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,GOBLET CELL                   |                                                                           |     1 2.0|
INTESTINE LARGE,RECTUM                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M       | 41       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,LYMPHOID                      |                                            1                 2            |     4 1.5|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |             X                                                             |     1    |
  DEGENERATION                              |                             3                                             |     1 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |     1     1     1        1  1        2     1        1                     |    11 1.1|
  HYPERPLASIA,KUPFFER CELL                  |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1           1  1  1  1     1  1  1  1  1     3  1  1  1  1  1  1         |    33 1.2|
  INFLAMMATION                              |                                                                           |     1 1.0|
  NECROSIS                                  |  1  1  1  1  1  1  1                    1  1  2  1  1  1  1  1  1  1      |    34 1.0|
  NECROSIS,COAGULATIVE                      |                          3  1                                             |     3 1.6|
  TENSION LIPOIDOSIS                        | X  X     X        X              X     X                    X  X  X       |    16    |
  THROMBUS                                  |                                                                           |     1 1.0|
  VACUOLIZATION CYTOPLASMIC                 |  2  2  2  2     2  2  2     3  2  2  2  1  2  1  1  2  2     2  2  3      |    34 1.9|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ACCUMULATION HYALINE DROPLET,DUCT         |                                         2                                 |     1 2.0|
  DEGENERATION                              |                                                                           |     1 1.0|
  FOCAL CELLULAR CHANGE                     |                                                                 1         |     2 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1        1  1     1     1        1  1  1            |    20 1.1|
  NECROSIS                                  |                                                                           |     1 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  129
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:58.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |                                                                           |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2     1  1  1  1  1  1  1  1  1  2  1  1  1  2     1  1  1  2         |    41 1.2|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         2                                 |     1 2.0|
  INFLAMMATION                              |                                         1     1                           |     2 1.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         2                                 |     1 2.0|
  INFLAMMATION                              |                                         1                                 |     1 1.0|
  MINERALIZATION                            |                                                        1                  |     2 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  POLYARTERITIS                             |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION,VALVE                        |                                1  1              2                        |     4 1.2|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  NECROSIS                                  |                                                                           |     1 2.0|
  POLYARTERITIS                             |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +       | 46       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +       | 46       |
  HYPERPLASIA                               |              1                                                            |     1 1.0|
  HYPERPLASIA,SPINDLE CELL                  |  2  1     1        1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1      |    38 1.3|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     2 1.5|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +       | 44       |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  HYPERPLASIA                               |                                   1                                       |     2 1.5|
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ECTOPIC THYMUS                            |                                                                           |     1    |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  130
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:58.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
PITUITARY GLAND                             | +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +       | 42       |
  ANGIECTASIS                               |                                                           1               |     1 1.0|
  HYPERPLASIA,PARS DISTALIS                 |                                                        1  1               |     8 1.7|
  POLYARTERITIS                             |                                                                           |     1 2.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     2 1.0|
  POLYARTERITIS                             |                                                                           |     1 2.0|
  ULTIMOBRANCHIAL CYST                      |        2        2        2  2  3  3           2        2  2     2         |    20 2.3|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  M  M  +  +       | 37       |
  ATROPHY                                   |  3     3  3  2  2     2  2  2     1     1           2  1        2  2      |    29 2.4|
OVARY                                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  ANGIECTASIS                               |        3                                                                  |     1 3.0|
  ATROPHY                                   | X     X  X  X     X        X  X  X  X  X  X  X  X           X     X       |    33    |
  CYST                                      | X  X  X           X  X     X              X                    X          |    13    |
  CYST,PERIOVARIAN TISSUE                   |                                     X              X                      |     3    |
  HEMATOCYST                                |                                                       X  X                |     3    |
  MINERALIZATION                            |        2                                                                  |     1 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                                                           |     4 3.5|
  DILATATION                                |                                                           1               |     3 3.0|
  FIBROSIS                                  |                                                     2                     |     2 2.5|
  HEMORRHAGE                                |                                                                           |     1 4.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  3  2  3  2  1  2  4  2  1  2  2  1  1  1  4  1  1  3  2     3  1  2      |    38 2.0|
  INFLAMMATION                              |     1                                                                     |     1 1.0|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                                                                           |     2 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     2 1.0|
  POLYARTERITIS                             |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  131
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:59.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA                               |                             3                                             |     2 3.5|
  INFARCT                                   |                X                                                          |     1    |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
LYMPH NODE,MANDIBULAR                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |  3                                                                 1      |     3 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +       | 43       |
  ATROPHY                                   |                                                                           |     1 1.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                                                                           |     1 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                 2           3                    2                        |     9 2.5|
  HYPERPLASIA,LYMPHOID                      |                    2                 3                          2         |    12 2.1|
  INFARCT                                   |                                                                           |     1 1.0|
THYMUS                                      | +  +  +  +  +  M  M  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +       | 37       |
  ATROPHY,CORTEX                            |  4        2                                                               |    15 2.9|
  CONGESTION                                |     2                                                                     |     1 2.0|
  HYPERPLASIA,LYMPHOID,MEDULLA              |           2  2        1        2  2  1  2     1  1     2  2  2            |    22 1.7|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  LACTATION                                 |                          1        1                 1  2                  |     5 1.6|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROUS OSTEODYSTROPHY,TURBINATE          |                       1                    1  1     1  1     1  1  2      |    10 1.1|
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROUS OSTEODYSTROPHY                    |  2        2                                                  1            |     9 1.3|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  132
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:59.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  1  1  2  2     1  1  1  1     1     2  1  1  2  2  2  1  2  2  1  1      |    33 1.5|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         1        1                        |     2 1.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                1                                       |     2 1.0|
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     1           1  1        1  2           1     1                        |    24 1.1|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CONGESTION                                |                                                                           |     1 4.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                               1                           |     1 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2     1  1  1     1  1  1  1  2  1  1     3  2     1  1  1  2  1      |    38 1.2|
  INFLAMMATION                              |                                                                           |     1 1.0|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FOCAL CELLULAR CHANGE                     |                          1                                                |     1 1.0|
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFLAMMATION,CORNEA                       |                                               1                           |     1 1.0|
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                                                     1                     |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1     1           1     1  1     1                                 |    16 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  133
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:59.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +       | 43       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  2     1  1  1     1        1     3        1           1  1  2         |    26 1.4|
ZYMBAL'S GLAND                              | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +       | 45       |
  INFLAMMATION                              |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     1 3.0|
  CYST,RENAL TUBULE                         |                                                                           |     2 1.0|
  GLOMERULOSCLEROSIS                        |     1                                                                     |     1 1.0|
  HYDRONEPHROSIS                            |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1  1  1     1        1  1  1  1  1  1  1  1  1        2  1  1  1      |    39 1.1|
  MINERALIZATION                            |                                                                           |     1 1.0|
  NEPHROPATHY                               |                                                  2     1                  |     2 1.5|
  PIGMENTATION,RENAL TUBULE                 |                                                                           |     1 3.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1  1  1  1  1     1  1  1  1  1     1  1  1  1  2  2  2  1      |    37 1.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  134
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:12.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  HYPERKERATOSIS                            |                                            2                       2      |          |
GALLBLADDER                                 | M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1           1                                             |          |
INTESTINE LARGE                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
INTESTINE LARGE,CECUM                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                   2     2                                 |          |
INTESTINE LARGE,COLON                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,RECTUM                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
INTESTINE SMALL                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
INTESTINE SMALL,DUODENUM                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
INTESTINE SMALL,ILEUM                       | A  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
INTESTINE SMALL,JEJUNUM                     | A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                  X                                        |          |
  EOSINOPHILIC FOCUS                        |                                                       X                   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                      1     1                              |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2     1     1  1  1        1  1     1     1  1  1  1  1           1   |          |
  INFLAMMATION                              |                                                                           |          |
  NECROSIS                                  |     1     1     1  1  1  1     1  1     1  1  1  1  1     1  1  1     2   |          |
  TENSION LIPOIDOSIS                        |                X     X        X  X              X  X  X  X                |          |
  VACUOLIZATION CYTOPLASMIC                 |     2     1     1              1  1     1     1  1  1     1  2        1  1|          |
MESENTERY                                   |                                                             +             |          |
  NECROSIS,FAT                              |                                                              4            |          |
PANCREAS                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  FOCAL CELLULAR CHANGE                     |                                                              1            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1        1  1  2        1  1  1  1  1  1  1  1     1  1        1  1|          |
  INFLAMMATION                              |                                                                           |          |
SALIVARY GLANDS                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                          2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1  1  1  1  2  1     1  1     1  1  1  1  2  1  2  1        1  2|          |
STOMACH                                     | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
STOMACH,FORESTOMACH                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  HYPERKERATOSIS                            |                                                                           |          |
STOMACH,GLANDULAR                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  135
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:12.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CYST                                      |                                                                           |          |
TONGUE                                      | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,ARTERY                       |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                                                           |          |
  FOCAL CELLULAR CHANGE                     |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |     2  2  3  1  3  2  2  2  3  2  2  2  1  2  2  1  2  2  2  2     2  1  1|          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ADRENAL GLAND,MEDULLA                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FOCAL CELLULAR CHANGE                     |                                                                          2|          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ISLETS, PANCREATIC                          | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                    1                                                      |          |
PARATHYROID GLAND                           | A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  CYST                                      |                                                                           |          |
  ECTOPIC THYMUS                            |                      X                                                    |          |
PITUITARY GLAND                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  + |          |
  ECTASIA                                   |                                      1                                    |          |
  HYPERPLASIA,PARS DISTALIS                 |                 1                                                     3   |          |
THYROID GLAND                               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  CYST,FOLLICLE                             |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                    2           1                                          |          |
  ULTIMOBRANCHIAL CYST                      |              2              3  2     2     4     2                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  136
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:12.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

CLITORAL GLAND                              | A  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  M  +  M  M  +  + |          |
  ATROPHY                                   |     4  2  3  3  3  3  3  3  3  4     3     4  3  3  4        3        4  3|          |
  INFLAMMATION                              |                                                                           |          |
OVARY                                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  ATROPHY                                   |          X     X     X  X  X  X  X  X     X  X  X     X  X     X          |          |
  CYST                                      |          X  X     X                             X  X  X  X                |          |
  CYST,PERIOVARIAN TISSUE                   |                                                                         X |          |
  HEMATOCYST                                |                            X                                X             |          |
  HYPERPLASIA,ADENOMATOUS                   |                                                                           |          |
  HYPERPLASIA,TUBULAR                       |                                            2                              |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           2                                                               |          |
  OVOTESTIS                                 |                                                                           |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  ATROPHY                                   |        3  3                                                     3        2|          |
  DILATATION                                |        2                                                                  |          |
  ECTASIA,VEIN                              |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2  2  2  3  3  3  2  2  3  3  2  3  3  3  2  3  3            |          |
  METAPLASIA,SQUAMOUS                       |                                                                           |          |
  THROMBUS                                  |                                                                           |          |
VAGINA                                      | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  ATROPHY                                   |                                                                          2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               2                           |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |     3                                                                     |          |
  HYPERPLASIA,LYMPHOID                      |                                2                                          |          |
LYMPH NODE                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID,AXILLARY             |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                    3     2|          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                 2        3                                      4         |          |
LYMPH NODE,MESENTERIC                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  137
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:12.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  ATROPHY                                   |                    2                                   3                  |          |
  HYPERPLASIA,LYMPHOID                      |                                                                 2         |          |
SPLEEN                                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                                                                       2   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     3  3                                                        3     2   |          |
  HYPERPLASIA,LYMPHOID                      |     3     4     3  3           2              2  1     3  4               |          |
  INFARCT                                   |                                                                           |          |
  NECROSIS                                  |                                                                          1|          |
THYMUS                                      | M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  + |          |
  ATROPHY,CORTEX                            |     4           3  3  3  3        4     2        4  3     2  2        4  4|          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |     2           2  2                    2        2                        |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  A  +  + |          |
  HYPERPLASIA                               |        2                                                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
SKIN                                        | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,CARTILAGE                    |                                                                           |          |
  FIBROUS OSTEODYSTROPHY                    |                          1  1  2     2  2  2  2  1  1     1  1            |          |
BONE,STERNUM                                | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                 2  2  3  1  2  2  1  1  2  3     1  2  2  1  3            |          |
SKELETAL MUSCLE                             | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,THALAMUS                   |                    1                                                      |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  138
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:13.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1     1  1  1  1  1  1  1     2  1     1  1  1  1  1        1     1|          |
PERIPHERAL NERVE                            | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  + |          |
  DEMYELINATION                             |                                                                           |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,AXON                         |                             2                                             |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                1                                          |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  + |          |
LUNG                                        | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                                                                    3      |          |
  EDEMA                                     |                                            1                              |          |
  HEMORRHAGE                                |                                                                       1   |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                            2                              |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1     1  2  1  1     1  1           1  2  1  1                 1|          |
  INFLAMMATION                              |                                         1                                 |          |
  PIGMENTATION,HEMOSIDERIN                  |                                                                           |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYTOPLASMIC ALTERATION,RESPIRATORY EPITHEL|           2                                                               |          |
    IUM                                     |                                                                           |          |
TRACHEA                                     | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
HARDERIAN GLAND                             | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  + |          |
  ECTASIA                                   |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1           1  1     1           1  1  1     1  1               |          |
LACRIMAL GLAND                              | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  + |          |
  ATROPHY                                   |                                                  1                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1           1  1  1           1     1  1     1     2     1            |          |
ZYMBAL'S GLAND                              | A  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  139
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:13.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                    3      |          |
  CYST,RENAL TUBULE                         |                                         1     1  1  1        1     1     1|          |
  GLOMERULOSCLEROSIS                        |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1        3  1  1  1  1  1  1  1  1  2  1  2  1  1  1        1  1|          |
  NEPHROPATHY                               |           1                                                               |          |
  PIGMENTATION,RENAL TUBULE                 |                                                                           |          |
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1  1  1  1  3     1  1  1  1  1     1  1  1  1              1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  140
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +       | 45       |
  HYPERKERATOSIS                            |                                                                           |     2 2.0|
GALLBLADDER                                 | A  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +       | 41       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                             1                     |     4 1.0|
INTESTINE LARGE                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE LARGE,CECUM                       | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,LYMPHOID                      |           3                       3                                       |     4 2.5|
INTESTINE LARGE,COLON                       | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERPLASIA,LYMPHOID                      |                                2                                          |     1 2.0|
INTESTINE LARGE,RECTUM                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE SMALL                             | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
INTESTINE SMALL,DUODENUM                    | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
INTESTINE SMALL,ILEUM                       | A  A  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 40       |
INTESTINE SMALL,JEJUNUM                     | A  A  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +       | 41       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                X                                                          |     2    |
  EOSINOPHILIC FOCUS                        |                                                                           |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |                                            1           1                  |     4 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1        1  1  1  1  1  1  1  1  1  2  1  2  1  1  1         |    32 1.0|
  INFLAMMATION                              |  1                                                                        |     1 1.0|
  NECROSIS                                  |           1  1  1  1  1  1     1  1  1  1  1     1  1  1  1  1     1      |    34 1.0|
  TENSION LIPOIDOSIS                        |                X  X  X     X  X  X              X           X     X       |    17    |
  VACUOLIZATION CYTOPLASMIC                 |  3  2  3  1     1  1  1           1           1  1        1  1  1  1      |    27 1.2|
MESENTERY                                   |                                                                           |  1       |
  NECROSIS,FAT                              |                                                                           |     1 4.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  FOCAL CELLULAR CHANGE                     |        2                                                                  |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2        1        2  1        1  1  1           1  1  1  2  1  1      |    31 1.1|
  INFLAMMATION                              |  1                                                                        |     1 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                          3              4                    1            |     4 2.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1     1  2  1  2  2  2     2  1  1  1     1  2  2  1  2     2      |    38 1.3|
STOMACH                                     | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
STOMACH,FORESTOMACH                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  HYPERKERATOSIS                            |                                                              2            |     1 2.0|
STOMACH,GLANDULAR                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  141
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CYST                                      |                       1              1                                    |     2 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFLAMMATION                              |                                      2                                    |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +       | 41       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +       | 41       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION,ARTERY                       |                                            2                              |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CYST                                      |                                               3                           |     1 3.0|
  FOCAL CELLULAR CHANGE                     |                          2                                                |     1 2.0|
  HYPERPLASIA,SPINDLE CELL                  |     1  2  2  2  1  2  3  3  2  2  2  1  2  2  2  2  3  3  2     1  2      |    44 1.9|
  VACUOLIZATION CYTOPLASMIC                 |                                3                                          |     1 3.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FOCAL CELLULAR CHANGE                     |                                                                           |     1 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                                                                 2         |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                    1      |     2 1.0|
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +       | 44       |
  CYST                                      |                             2                                             |     1 2.0|
  ECTOPIC THYMUS                            |                                                                           |     1    |
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  ECTASIA                                   |                                                                           |     1 1.0|
  HYPERPLASIA,PARS DISTALIS                 |                    2                                   2                  |     4 2.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  CYST,FOLLICLE                             |                       3                                   4               |     2 3.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1  1                                    |     4 1.2|
  ULTIMOBRANCHIAL CYST                      |           2  2  2                 2           2                           |    11 2.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  142
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

CLITORAL GLAND                              | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +       | 38       |
  ATROPHY                                   |     3  4  3  3  4  3  4  3  4     3  3  3  3     3  3  4  4  4  4  3      |    38 3.3|
  INFLAMMATION                              |                                                                    1      |     1 1.0|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   | X  X  X     X  X  X  X  X  X  X  X  X  X  X     X           X  X  X       |    32    |
  CYST                                      |    X  X  X                             X     X  X  X  X                   |    15    |
  CYST,PERIOVARIAN TISSUE                   |                            X  X  X  X  X  X        X  X     X             |    10    |
  HEMATOCYST                                |                                           X              X                |     4    |
  HYPERPLASIA,ADENOMATOUS                   |                                         3                                 |     1 3.0|
  HYPERPLASIA,TUBULAR                       |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              2            |     2 2.0|
  OVOTESTIS                                 |                                                     2                     |     1 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |  3  3                                                                     |     6 2.8|
  DILATATION                                |                                                                    4      |     2 3.0|
  ECTASIA,VEIN                              |                                               4                           |     1 4.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |        2  3  2  2  2  3  3  3  3  3     2  3  3     2  4  3  3  2         |    35 2.6|
  METAPLASIA,SQUAMOUS                       |  2                                                                        |     1 2.0|
  THROMBUS                                  |                                               4                           |     1 4.0|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ATROPHY                                   |     2                                                                     |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              1            |     2 1.5|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |        4                                                                  |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA,LYMPHOID,AXILLARY             |                                      4                                    |     1 4.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |  3  4                                                                     |     4 3.0|
  HEMORRHAGE                                |              4                                                            |     1 4.0|
  HYPERPLASIA,LYMPHOID                      |        2                 2                 2                    4         |     7 2.7|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  143
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  ATROPHY                                   |  3  4  3  3                                                               |     6 3.0|
  HYPERPLASIA,LYMPHOID                      |                       2                             2                     |     3 2.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CONGESTION                                |              2                    2  2     3                              |     5 2.2|
  HEMATOPOIETIC CELL PROLIFERATION          |        4                                   3                              |     6 3.0|
  HYPERPLASIA,LYMPHOID                      |                       2  2  2     1        2        3     3               |    16 2.5|
  INFARCT                                   |                                            3                              |     1 3.0|
  NECROSIS                                  |                                                                           |     1 1.0|
THYMUS                                      | M  M  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +       | 36       |
  ATROPHY,CORTEX                            |           2  2           3  4     4  2  3        3  2  3     3     4      |    25 3.0|
  HYPERPLASIA,LYMPHOID,MEDULLA              |           2           2  3           3              1                     |    10 2.1|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA                               |                                   3                                       |     2 2.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2                              |     1 2.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  DEGENERATION,CARTILAGE                    |                                            4                              |     1 4.0|
  FIBROUS OSTEODYSTROPHY                    |     1     1        1  2     2     2  1  2        1     2  1               |    22 1.4|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |     1     1  2  2  2  2  1  2     2  1  3  3  1  1  3  3  2  2  3  1      |    35 1.8|
SKELETAL MUSCLE                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  MINERALIZATION,THALAMUS                   |                                                                           |     1 1.0|
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  144
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1  1     1  1  1     2        1  1  1  1     1                 1  1      |    30 1.0|
PERIPHERAL NERVE                            | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  DEMYELINATION                             |                                            1                              |     1 1.0|
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION,AXON                         |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CONGESTION                                |                                                                           |     1 3.0|
  EDEMA                                     |                                                                           |     1 1.0|
  HEMORRHAGE                                |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                      2  1                          2      |     4 1.7|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1     1  2  1  1  1  2     1        1  2  1  1  2  1         |    28 1.2|
  INFLAMMATION                              |                          1                 2                 2            |     4 1.5|
  PIGMENTATION,HEMOSIDERIN                  |        4                                                                  |     1 4.0|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CYTOPLASMIC ALTERATION,RESPIRATORY EPITHEL|                                                                           |     1 2.0|
    IUM                                     |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ECTASIA                                   |                       2                                                   |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1              1  1  1        1  1     1  1        1     1  2     1      |    21 1.0|
LACRIMAL GLAND                              | M  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  M  M       | 37       |
  ATROPHY                                   |        3           2     2                          2                     |     5 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1  2  2  2     2                 1  1  1  1  2            |    21 1.2|
ZYMBAL'S GLAND                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +       | 41       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  145
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |     1 3.0|
  CYST,RENAL TUBULE                         |  1                 1                                                      |     9 1.0|
  GLOMERULOSCLEROSIS                        |                       2                                                   |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1  1  1  1  1  3  2     2  1  2  2     1  1  3  1  2  1  2      |    37 1.3|
  NEPHROPATHY                               |                          1                                                |     2 1.0|
  PIGMENTATION,RENAL TUBULE                 |        1                 1                                                |     2 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  2  1  2  1  1  1  1  1  1  1     1  1  2  1  2  1  1      |    38 1.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  146
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:29.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | A                                                           +  M  +  M  + |          |
  HYPERKERATOSIS                            |                                                                    2      |          |
GALLBLADDER                                 | A                                                           +  +  M  +  + |          |
INTESTINE LARGE                             | A                                                           A  +  A  +  + |          |
INTESTINE LARGE,CECUM                       | M                                                           A  +  A  A  + |          |
INTESTINE LARGE,COLON                       | M                                                           A  +  A  +  + |          |
INTESTINE LARGE,RECTUM                      | A                                                           A  +  A  +  + |          |
INTESTINE SMALL                             | M                                                           A  +  A  +  + |          |
INTESTINE SMALL,DUODENUM                    | M                                                           A  +  A  A  + |          |
INTESTINE SMALL,ILEUM                       | M                                                           A  +  A  A  + |          |
INTESTINE SMALL,JEJUNUM                     | M                                                           A  +  A  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |              2                                                            |          |
  BASOPHILIC FOCUS                          |          X                                                                |          |
  EOSINOPHILIC FOCUS                        |       X                                                                   |          |
  FIBROSIS                                  |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                               1                           |          |
  HYPERPLASIA,BILE DUCT                     |                                                                           |          |
  HYPERPLASIA,KUPFFER CELL                  |                                                                          2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  2  1  1  1  1  1  1  1  1     1  1  1  2  1  1     1  1               |          |
  NECROSIS                                  |     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1        1               |          |
  TENSION LIPOIDOSIS                        |       X     X        X     X     X  X        X                            |          |
  VACUOLIZATION CYTOPLASMIC                 |     2        2  1  1  1  1  1  2  1     1     1  1        1     2         |          |
PANCREAS                                    | A                                                           A  +  A  +  A |          |
  ECTASIA,DUCT                              |                                                                           |          |
SALIVARY GLANDS                             | A                                                           +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              1  1  1  1  1|          |
STOMACH                                     | M                                                           A  +  A  +  + |          |
STOMACH,FORESTOMACH                         | M                                                           A  +  A  +  + |          |
  HYPERKERATOSIS                            |                                                                          2|          |
  HYPERPLASIA                               |                                                                 2         |          |
STOMACH,GLANDULAR                           | M                                                           A  +  A  +  + |          |
  MINERALIZATION                            |                                                                           |          |
TONGUE                                      | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  147
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:29.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +                                                           M  M  +  M  + |          |
BLOOD VESSEL,AORTA                          | +                                                           M  M  +  M  + |          |
HEART                                       | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | A                                                           A  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | A                                                           A  +  +  +  + |          |
  HYPERPLASIA,SPINDLE CELL                  |                                                                 2  2  2   |          |
ADRENAL GLAND,MEDULLA                       | A                                                           A  +  M  +  + |          |
ISLETS, PANCREATIC                          | A                                                           A  +  A  +  A |          |
PARATHYROID GLAND                           | A                                                           +  M  +  M  M |          |
PITUITARY GLAND                             | A                                                           M  M  +  M  + |          |
  ANGIECTASIS                               |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                                           |          |
THYROID GLAND                               | A                                                           +  M  +  M  + |          |
  ULTIMOBRANCHIAL CYST                      |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +                                                           +  +  +  +  + |          |
  ATROPHY                                   |                                                                 4  2  4  3|          |
OVARY                                       | A     +  +     +  +  +           +        +  +              +  +  +  +  + |          |
  ATROPHY                                   |                                                             X             |          |
  CYST                                      |       X  X     X     X           X        X                             X |          |
  CYST,PERIOVARIAN TISSUE                   |                   X                          X                            |          |
  HEMATOCYST                                |                                                                           |          |
  INFLAMMATION                              |                                                                           |          |
UTERUS                                      | A     +     +  +  +  +     +  +  +     +     +     +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                              4           4|          |
  DILATATION                                |                                                                           |          |
  FIBROSIS                                  |                       1           1                                       |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |        3     2  3  3  4     3     3     2     2     3  3  3               |          |
  INFLAMMATION                              |                                                                           |          |
VAGINA                                      | A                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  148
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:29.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  ATROPHY                                   |                                                              4           4|          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +                                                           +  +  +  +  + |          |
  HYPERPLASIA                               |                                                              3            |          |
LYMPH NODE                                  | +                                                           +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | A                                                           +  +  +  +  + |          |
  HEMORRHAGE                                |                                                                    2      |          |
  HYPERPLASIA,LYMPHOID                      |                                                              2     2      |          |
LYMPH NODE,MESENTERIC                       | +                                                           A  +  A  +  + |          |
  INFLAMMATION                              |                                                                           |          |
SPLEEN                                      | M        +           +     +                       +        +  +  A  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |                                                                       4   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                             1                                         4   |          |
  HYPERPLASIA,LYMPHOID                      |                                                                       1   |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                       1   |          |
  NECROSIS                                  |                                                                       1   |          |
THYMUS                                      | A                                                           +  +  M  M  + |          |
  ATROPHY,CORTEX                            |                                                              4  4         |          |
  ECTOPIC PARATHYROID GLAND                 |                                                                X          |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | A                             +                             +  +  +  +  M |          |
  HYPERPLASIA                               |                                4                                          |          |
  METAPLASIA,SQUAMOUS                       |                                4                                          |          |
SKIN                                        | A                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +                                                           +  +  +  +  + |          |
BONE,FEMUR                                  | +                                                           +  +  +  +  + |          |
BONE,STERNUM                                | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  149
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:30.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                                                                           |          |
SKELETAL MUSCLE                             | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +                                                           +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +                                                           +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +                                                           +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1                                                                        |          |
PERIPHERAL NERVE                            | +                                                           +  +  +  +  + |          |
SPINAL CORD                                 | +                                                           +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | A                                                           +  M  M  M  + |          |
LUNG                                        | A                                      +                    +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1  1      |          |
NOSE                                        | +                                                           +  +  +  +  + |          |
  INFLAMMATION                              |                                                                          2|          |
TRACHEA                                     | A                                                           +  M  +  M  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A                                                           A  +  A  A  A |          |
HARDERIAN GLAND                             | +                                                           +  +  +  +  M |          |
  HYPERPLASIA                               |                                                                    4      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              1            |          |
LACRIMAL GLAND                              | A                                                           +  +  +  M  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1  1     1|          |
ZYMBAL'S GLAND                              | +                                                           +  +  M  +  M |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | A                                                           +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET              |                                                                       3   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  150
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:30.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

  CYST,RENAL TUBULE                         |                                                                       1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              1  1  1     1|          |
  VACUOLIZATION CYTOPLASMIC,RENAL TUBULE    |                                                                           |          |
URINARY BLADDER                             | A                                                           A  +  A  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                       1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  151
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:31.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +                    +                                                    |  5       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
GALLBLADDER                                 | +                    +                                                    |  6       |
INTESTINE LARGE                             | +                    +                                                    |  5       |
INTESTINE LARGE,CECUM                       | +                    +                                                    |  4       |
INTESTINE LARGE,COLON                       | +                    +                                                    |  5       |
INTESTINE LARGE,RECTUM                      | +                    +                                                    |  5       |
INTESTINE SMALL                             | +                    +                                      +     +       |  7       |
INTESTINE SMALL,DUODENUM                    | +                    +                                      +             |  5       |
INTESTINE SMALL,ILEUM                       | +                    +                                                    |  4       |
INTESTINE SMALL,JEJUNUM                     | +                    +                                      +     +       |  7       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |                                                                           |     1 2.0|
  BASOPHILIC FOCUS                          | X                                                                         |     2    |
  EOSINOPHILIC FOCUS                        |                                                                           |     1    |
  FIBROSIS                                  |                          1                                                |     1 1.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                       1                 1                                 |     3 1.0|
  HYPERPLASIA,BILE DUCT                     |                          1                                                |     1 1.0|
  HYPERPLASIA,KUPFFER CELL                  |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  3     1  1     1     1  1  1  1     1  1  2  1  1  1     1  1  1      |    36 1.1|
  NECROSIS                                  |  1  1  1  1  1  1  1        1  1  1  1     1  1  1  1  2     1  1  1      |    36 1.0|
  TENSION LIPOIDOSIS                        | X           X  X     X     X  X  X              X  X  X     X  X  X       |    20    |
  VACUOLIZATION CYTOPLASMIC                 |  1  1     1  1  1  1  2  2  2  2  1  1  3  2  2  2  1  2  1  3  1  2      |    36 1.4|
PANCREAS                                    | +                    +                                +                   |  5       |
  ECTASIA,DUCT                              |                                                        4                  |     1 4.0|
SALIVARY GLANDS                             | +                    +                                                    |  7       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     7 1.0|
STOMACH                                     | +                    +                                                    |  5       |
STOMACH,FORESTOMACH                         | +                    +                                                    |  5       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
  HYPERPLASIA                               |                                                                           |     1 2.0|
STOMACH,GLANDULAR                           | +                    +                                                    |  5       |
  MINERALIZATION                            |                       1                                                   |     1 1.0|
TONGUE                                      | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  152
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:31.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +                    +                                                    |  5       |
BLOOD VESSEL,AORTA                          | +                    +                                                    |  5       |
HEART                                       | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +                    +                                +                   |  7       |
ADRENAL GLAND,CORTEX                        | +                    +                                                    |  6       |
  HYPERPLASIA,SPINDLE CELL                  |  1                    1                                                   |     5 1.6|
ADRENAL GLAND,MEDULLA                       | +                    +                                +                   |  6       |
ISLETS, PANCREATIC                          | +                    +                                                    |  4       |
PARATHYROID GLAND                           | +                    M                                                    |  3       |
PITUITARY GLAND                             | +                    +                                                    |  4       |
  ANGIECTASIS                               |                       2                                                   |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |                       2                                                   |     1 2.0|
THYROID GLAND                               | +                    +                                                    |  5       |
  ULTIMOBRANCHIAL CYST                      |  2                    3                                                   |     2 2.5|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +                    M                                                    |  7       |
  ATROPHY                                   |  3                                                                        |     5 3.2|
OVARY                                       | +  +                 +  +        +  +  +              +        +          | 22       |
  ATROPHY                                   | X                    X                                                    |     3    |
  CYST                                      |    X                             X                                        |     9    |
  CYST,PERIOVARIAN TISSUE                   |                                        X              X        X          |     5    |
  HEMATOCYST                                |                      X                                                    |     1    |
  INFLAMMATION                              |                                      4                                    |     1 4.0|
UTERUS                                      | +  +        +     +  +        +           +        +     +  +  +  +       | 30       |
  ATROPHY                                   |                                                                           |     2 4.0|
  DILATATION                                |                                                     4           4         |     2 4.0|
  FIBROSIS                                  |                                                                           |     2 1.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  3  2        2     3           3           2              4  3     3      |    21 2.8|
  INFLAMMATION                              |                       4                                                   |     1 4.0|
VAGINA                                      | +                    +                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  153
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:32.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  ATROPHY                                   |                                                                           |     2 4.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +                    +                                                    |  8       |
  HYPERPLASIA                               |                       2                                                   |     2 2.5|
LYMPH NODE                                  | +     +              +  +              +                 +  +             | 13       |
LYMPH NODE,MANDIBULAR                       | +     +              +                                                    |  8       |
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |     3 2.0|
LYMPH NODE,MESENTERIC                       | +     +              +  +                                +  +             | 10       |
  INFLAMMATION                              |                       2                                                   |     1 2.0|
SPLEEN                                      | +     +              +  +  +        +              +     +  +     +       | 18       |
  ANGIECTASIS                               |  2                                                                        |     1 2.0|
  ATROPHY                                   |                                                                           |     1 4.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     2 2.5|
  HYPERPLASIA,LYMPHOID                      |                       1     3                       3                     |     4 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 1.0|
  NECROSIS                                  |                                                                           |     1 1.0|
THYMUS                                      | +                    M                                                    |  4       |
  ATROPHY,CORTEX                            |  3                                                                        |     3 3.6|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |  2                                                                        |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +                    M                                                    |  6       |
  HYPERPLASIA                               |                                                                           |     1 4.0|
  METAPLASIA,SQUAMOUS                       |                                                                           |     1 4.0|
SKIN                                        | +                    +                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +                    +                                                    |  8       |
BONE,FEMUR                                  | +                    +                                                    |  8       |
BONE,STERNUM                                | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  154
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:32.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                       2                                                   |     1 2.0|
SKELETAL MUSCLE                             | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +                    +                                                    |  8       |
BRAIN,CEREBELLUM                            | +                    +                                                    |  8       |
BRAIN,CEREBRUM                              | +                    +                                                    |  8       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                       1                                                   |     2 1.0|
PERIPHERAL NERVE                            | +                    +                                                    |  8       |
SPINAL CORD                                 | +                    +                                                    |  8       |
SPINAL CORD,THORACIC                        | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +                    +                                                    |  4       |
LUNG                                        | +                    +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     4 1.0|
NOSE                                        | +                    +                                                    |  8       |
  INFLAMMATION                              |                                                                           |     1 2.0|
TRACHEA                                     | +                    M                                                    |  4       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +                    +                                                    |  3       |
HARDERIAN GLAND                             | +                    +                                                    |  7       |
  HYPERPLASIA                               |                                                                           |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
LACRIMAL GLAND                              | +                    +                                                    |  6       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     4 1.0|
ZYMBAL'S GLAND                              | +                    +                                                    |  6       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +     +              +                                                    |  8       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  155
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:32.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

  CYST,RENAL TUBULE                         |  1     3                                                                  |     3 1.6|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     6 1.0|
  VACUOLIZATION CYTOPLASMIC,RENAL TUBULE    |                       2                                                   |     1 2.0|
URINARY BLADDER                             | +                    +                                                    |  5       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     4 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  156
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:36.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7|
                                            | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0|
                                            | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|   S  R   R|
                                            | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1|   U  V   I|
25MG   FS-2YR 21    21                      | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +                                                     +  +  +  +  + |          |
GALLBLADDER                                 | +  +  +                                                     +  +  +  +  + |          |
INTESTINE LARGE                             | +  +  +                                                     +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  +                                                     +  +  +  A  + |          |
INTESTINE LARGE,COLON                       | +  +  +                                                     +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  +  +                                                     +  +  +  +  + |          |
INTESTINE SMALL                             | +  +  +                                                     +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  +  +                                                     +  +  +  +  A |          |
  INFLAMMATION                              |                                                                       4   |          |
INTESTINE SMALL,ILEUM                       | +  +  +                                                     +  +  +  A  + |          |
INTESTINE SMALL,JEJUNUM                     | +  +  +                                                     +  +  +  A  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |          X                                                                |          |
  CLEAR CELL FOCUS                          |                   X                                                       |          |
  EOSINOPHILIC FOCUS                        |                   X                                                       |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     2        1           1                             1           1  1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1  3  1  3  1  1  1     1  2  1  1  1  3  1  1  1  1  1     2  1   |          |
  NECROSIS                                  |           1  1  1  1  1     1     1     1     1  1     1  1  1            |          |
  NECROSIS,COAGULATIVE                      |        4                                                                  |          |
  TENSION LIPOIDOSIS                        |                   X                 X        X           X                |          |
  VACUOLIZATION CYTOPLASMIC                 |     1  1           2           2  2  1  2  2  1  1  1  1     1  1  1     2|          |
PANCREAS                                    | +  +  +                                                     +  +  +  +  + |          |
  ATROPHY                                   |                                                                       3   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1                                                     1  1        1|          |
SALIVARY GLANDS                             | +  +  +                                                     +  +  +  +  + |          |
  ATROPHY                                   |                                                                 3         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2                                                     2        1  1|          |
STOMACH                                     | +  +  +                                                     +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  +                                                     +  +  +  +  + |          |
  HYPERKERATOSIS                            |                                                                    2      |          |
STOMACH,GLANDULAR                           | +  +  +                                                     +  +  +  +  + |          |
  CYST                                      |                                                                          1|          |
TONGUE                                      | +  +  +                                                     +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  157
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:36.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7|
                                            | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0|
                                            | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|   S  R   R|
                                            | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1|   U  V   I|
25MG   FS-2YR 21    21                      | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +                                                     +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  M  +                                                     +  +  +  +  + |          |
HEART                                       | +  +  +                                                     +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +                                                     +  +  +  +  + |          |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                                         X |          |
ADRENAL GLAND,CORTEX                        | +  +  +                                                     +  +  +  +  + |          |
  HYPERPLASIA,SPINDLE CELL                  |  2  1                                                        1  2  1  1  2|          |
ADRENAL GLAND,MEDULLA                       | +  +  +                                                     +  +  +  +  + |          |
ISLETS, PANCREATIC                          | +  +  +                                                     +  +  +  +  + |          |
PARATHYROID GLAND                           | +  M  +                                                     M  +  +  M  M |          |
PITUITARY GLAND                             | +  +  +                                   +                 +  +  M  +  M |          |
  CYST                                      |                                                              1            |          |
THYROID GLAND                               | +  +  +                                                     +  +  +  M  + |          |
  DEPLETION SECRETORY                       |     2                                                                     |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                          4|          |
  INFLAMMATION                              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  M  +                                                     M  +  +  +  + |          |
  ATROPHY                                   |  4     3                                                           4  4  4|          |
OVARY                                       | +  +  +  +  +        +     +  +  +     +           +  +     +  +  +  M  + |          |
  AMYLOID DEPOSITION                        |  3                                                                        |          |
  ATROPHY                                   |    X  X                                                           X     X |          |
  CYST                                      |          X  X        X        X  X                    X        X  X       |          |
  CYST,PERIOVARIAN TISSUE                   |                            X           X           X                      |          |
  HEMORRHAGE                                |  3                                                                        |          |
UTERUS                                      | +  +  +  +  +  +     +  +  +                 +     +     +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |  3     4                                                           4      |          |
  DILATATION                                |                                                     2                     |          |
  FIBROSIS                                  |                       2                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  158
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:36.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7|
                                            | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0|
                                            | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|   S  R   R|
                                            | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1|   U  V   I|
25MG   FS-2YR 21    21                      | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |           2  3  4     2  3  3                 2           3  2  2        2|          |
VAGINA                                      | +  +  +                                                     +  +  +  +  + |          |
  AMYLOID DEPOSITION                        |  2                                                                        |          |
  ATROPHY                                   |        3                                                           2      |          |
  DYSPLASIA                                 |  2                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +                                                     +  +  +  +  + |          |
  CONGESTION                                |  2                                                                        |          |
  HYPERPLASIA                               |  3                                                                 4     3|          |
  MYELOFIBROSIS                             |     4                                                                     |          |
LYMPH NODE                                  | +  +  +                 +                                   +  +  +  A  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +                                                     +  +  +  A  + |          |
  ATROPHY                                   |  4                                                                        |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |     2                                                                     |          |
  POLYARTERITIS                             |                                                                           |          |
LYMPH NODE,MESENTERIC                       | +  +  +                                                     M  +  +  A  + |          |
  ATROPHY                                   |  4                                                                 4      |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     4                                                                     |          |
  HEMORRHAGE                                |                                                                           |          |
SPLEEN                                      | +  +  +                    +                 +              +  +  +  +  + |          |
  AMYLOID DEPOSITION                        |  1                                                                        |          |
  ATROPHY                                   |  2                                                                 2  2   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |        3                                                        3  4  4   |          |
  HYPERPLASIA,LYMPHOID                      |                                               3              1            |          |
  NECROSIS                                  |                                                                 2         |          |
  POLYARTERITIS                             |                                                                 2         |          |
THYMUS                                      | M  M  +  +              +                                   +  +  M  M  + |          |
  ATROPHY,CORTEX                            |        4                                                     3           3|          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |           2                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  159
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:37.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7|
                                            | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0|
                                            | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|   S  R   R|
                                            | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1|   U  V   I|
25MG   FS-2YR 21    21                      | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +           +                                         +  +  +  +  + |          |
  LACTATION                                 |  2                                                                        |          |
SKIN                                        | +  +  +                                                     +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +                                                     +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +                                                     +  +  +  +  + |          |
BONE,STERNUM                                | +  +  +                                                     +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |        2                                                        2        1|          |
SKELETAL MUSCLE                             | +  +  +                                                     +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +                                                     +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +                                                     +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +                                                     +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                                                                 1     2   |          |
PERIPHERAL NERVE                            | +  +  +                                                     +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +