National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11429

NCTR Study 211601 Pathology Tables

NCTR EXP/TEST:   211601                                                                                      PAGE:    1
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |  2                                                                        |          |
  ULCER                                     |           3                                                               |          |
GALLBLADDER                                 | +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                          1|          |
INTESTINE LARGE                             | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  A  M  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,COLON                       | +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  EROSION                                   |                                                                           |          |
INTESTINE SMALL                             | +  +  A  A  +  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  +  A  A  +  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
INTESTINE SMALL,ILEUM                       | +  +  A  A  +  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                       2   |          |
INTESTINE SMALL,JEJUNUM                     | +  +  A  A  +  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                    1                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1        1  1              1  1  1  1  1  1  1  1  2     1     1  2  1|          |
  INFLAMMATION                              |                                1                                          |          |
  NECROSIS                                  |     1                          1  2  1  1     1        1  1  1     1  1  1|          |
  NECROSIS,COAGULATIVE                      |                    2                                                      |          |
  TENSION LIPOIDOSIS                        |                                              X              X  X  X  X  X |          |
  VACUOLIZATION CYTOPLASMIC                 |        1     1     1        1                             1     1     1  1|          |
MESENTERY                                   |                            +                                              |          |
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                           |          |
  FOCAL CELLULAR CHANGE                     |        1                                                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     2  1                    1  1  1           1  1  1  1  1     1  1|          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,DUCT                          |  3                                                                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1           1  1  2     1     2  2  1  1  1  2  2     1     1  1  1|          |
STOMACH                                     | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,GLANDULAR                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    2
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CRYSTALS                                  |                                                                           |          |
  CYST                                      |                                                                           |          |
  DEGENERATION,HYALINE                      |                                                                           |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,MAST CELL           |                                                                 2         |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  M  +  M  +  +  M  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |        1                                                                  |          |
  INFLAMMATION                              |           4                                                               |          |
  POLYARTERITIS                             |                                                                           |          |
  THROMBUS                                  |        4                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                                           |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTOPIC TISSUE                            |                               X                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |     1  3     2  2     1  2     2     2  2  2  3  2  2  2  2  2  2  3  2  2|          |
  THROMBUS                                  |        2                                                                  |          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  VACUOLIZATION CYTOPLASMIC                 |                                         2                                 |          |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  M  +  M  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  ECTOPIC THYMUS                            |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      3                                    |          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
PITUITARY GLAND                             | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,PARS DISTALIS                 |                                1                    3        1            |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    3
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  DEGENERATION                              |              2                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1        1|          |
  ULTIMOBRANCHIAL CYST                      |                    3           2     2  2     2                          3|          |
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |                                                                +          |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | M  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |        4        4  3     3  4     4  4  2  3  4  3  2     4  3  4  4  3  4|          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   | X     X  X  X     X  X  X     X     X     X  X  X     X  X  X  X  X  X    |          |
  CONGESTION                                |                                      2                                    |          |
  CYST                                      |                                  X     X     X     X                    X |          |
  CYST,PERIOVARIAN TISSUE                   |       X                 X              X  X  X                 X          |          |
  HEMATOCYST                                |                                                             X     X       |          |
  HYPERPLASIA,ADENOMATOUS                   |                                4  4                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      2                                    |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |  3        4                                                               |          |
  DILATATION                                |                    3                                                      |          |
  FIBROSIS                                  |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |     1  2        2           2  3     3  3  3  3  3  2  2  2  3  2  1  2  3|          |
  PROLAPSE                                  |                                                                           |          |
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |  3        4                                                               |          |
  DYSPLASIA                                 |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |           3           3                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    4
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                          2           2                 2              2   |          |
LYMPH NODE,MESENTERIC                       | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                     2                     |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                                2        2                                 |          |
SPLEEN                                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           3        3                                                      |          |
  HEMATOPOIETIC CELL PROLIFERATION          |           3        3     3                                                |          |
  HYPERPLASIA,LYMPHOID                      |              2                          2  2        1        3            |          |
THYMUS                                      | M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
  ATROPHY,CORTEX                            |        4     3  3  4           3  3  3  3  4  3  3  3     4  3  4  3  2   |          |
  CONGESTION                                |                                               2                           |          |
  ECTOPIC PARATHYROID GLAND                 |                                                          X                |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                      2        2     1     2  2     3     3|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  + |          |
  HYPERPLASIA                               |              2                                                            |          |
  INFLAMMATION                              |                                                                           |          |
  LACTATION                                 |        2                                                        2         |          |
SKIN                                        | +  +  +  +  M  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                                         2        2        4     1     2  2|          |
BONE,STERNUM                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |        2           1  2        3  3     3  2  3  3  2  2  2  1  2  1  2  3|          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                    1                          2                           |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    5
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:31.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |        2                                                                  |          |
  THROMBUS                                  |        3                                                                  |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |        2                                                                  |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1        1     1           1     1        1  1  1  1  2           1|          |
  THROMBUS                                  |        3                                                                  |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |     3                                                                     |          |
  THROMBUS                                  |        2                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FOREIGN BODY                              |       X                                                                   |          |
  HEMORRHAGE                                |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1     1  1     2     2  2  1  1  1  1  1     1        1  2|          |
  INFLAMMATION                              |        4  4                                            1                  |          |
  THROMBUS                                  |        4                                                                  |          |
NOSE                                        | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST,NASOLACRIMAL DUCT                    |                                                                           |          |
  INFLAMMATION                              |           3                                                               |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |  4                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  A  +  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  + |          |
  DEGENERATION,RETINA                       |                                                                           |          |
  THROMBUS                                  |        3                                                                  |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    6
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:32.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 3| 6| 0| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 0| 6| 7| 5| 0| 5| 7| 8| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 3| 2| 2| 0| 4| 2| 4| 0| 4| 5| 5| 5| 5| 6| 6| 5| 5| 5| 6| 6| 6| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 3| 8| 6| 7| 8| 0| 1| 1| 8| 9| 9| 9| 9| 2| 3| 2| 3| 3| 6| 6| 5| 9| 9| 9|   U  V   I|
CONTRL F2YR   01     1                      | 1| 8| 8| 3| 9| 2| 4| 0| 2| 9| 1| 2| 3| 4| 9| 0| 9| 0| 1| 6| 7| 3| 0| 1| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1           1  1  1              1  1     1     1|          |
  THROMBUS                                  |        2                                                                  |          |
LACRIMAL GLAND                              | +  +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  + |          |
  ATROPHY                                   |                                                  4                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1                 1     2  1  1  1  3  1  2     1     1  1   |          |
ZYMBAL'S GLAND                              | +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |     2                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                        3                  |          |
  CONGESTION                                |           1                                                               |          |
  CYST,RENAL TUBULE                         |              1                          2                 1        1     1|          |
  HYDRONEPHROSIS,BILATERAL                  |                          2                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1     2  1        2  1  2  1  1  1  1  1  2  1  2     1  1  1|          |
  INFLAMMATION                              |                                                                           |          |
  NEPHROPATHY                               |                                1           1                             1|          |
  POLYARTERITIS                             |                                                                           |          |
URINARY BLADDER                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1     1  1  1     1  1  1  1  1  1  1  1  2     2     1  1  1|          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    7
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:44.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
  ULCER                                     |                                                                           |     1 3.0|
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                       1     1                                       |     4 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
  HYPERPLASIA,LYMPHOID                      |                    2              2                 2     2     2         |     5 2.0|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +       | 44       |
  EROSION                                   |           2     2                                                         |     2 2.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 41       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 40       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 40       |
  HYPERPLASIA,LYMPHOID                      |                                            2                              |     2 2.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 41       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                                  X                                        |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |     1           1                                                         |     3 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  1  1  1  1  1  1        1  1  1  1  1  2  2  1     3               |    33 1.2|
  INFLAMMATION                              |                                                           1               |     2 1.0|
  NECROSIS                                  |  1  1     1  1  1  1  1  1  1  1  1     1  1  1     1  1  1  1  1  1      |    32 1.0|
  NECROSIS,COAGULATIVE                      |                                                                           |     1 2.0|
  TENSION LIPOIDOSIS                        | X     X           X  X           X  X  X     X     X           X  X       |    17    |
  VACUOLIZATION CYTOPLASMIC                 |        1  1  1  1  1  1  2  2  1  1  1  2  2  1     1  1  1     1         |    26 1.1|
MESENTERY                                   |                                                                           |  1       |
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |                                      2                                    |     1 2.0|
  FOCAL CELLULAR CHANGE                     |                                                              1            |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1     1  1  1  1  1     1              1     1        1  1      |    26 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA,DUCT                          |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  2  1  2  2  1  2  2  2  1  2  1  1     1  1  1  1  1  2  1      |    38 1.3|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    8
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CRYSTALS                                  |                                                           2               |     1 2.0|
  CYST                                      |  1                                                     1                  |     2 1.0|
  DEGENERATION,HYALINE                      |                                                           2               |     1 2.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,MAST CELL           |                                                           2               |     2 2.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 1.0|
  INFLAMMATION                              |                                                                           |     1 4.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
  THROMBUS                                  |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                       X                   |     1    |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ECTOPIC TISSUE                            |                                                                           |     1    |
  HYPERPLASIA,SPINDLE CELL                  |  2  2  2  2  2  2  2  2  2  2  2  1  3  2  3  2  2  3  2  2  1  2  2      |    43 2.0|
  THROMBUS                                  |                                                                           |     1 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                                2           2                              |     2 2.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
PARATHYROID GLAND                           | +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +       | 38       |
  ECTOPIC THYMUS                            |                                                                X          |     1    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 3.0|
  VACUOLIZATION CYTOPLASMIC                 |                                            2                              |     1 2.0|
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +       | 45       |
  HYPERPLASIA,PARS DISTALIS                 |              1                                                            |     4 1.5|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:    9
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  DEGENERATION                              |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2                 1                                                |     4 1.2|
  ULTIMOBRANCHIAL CYST                      |              2           2                 2  2     2                     |    11 2.1|
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  ATROPHY                                   |  4  3  4  3  3  3  4  4  3     4  3  3  4  3  4  4  3  3  3  3  2  3      |    40 3.3|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   | X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X       |    39    |
  CONGESTION                                |                                                                           |     1 2.0|
  CYST                                      |             X  X     X        X                                   X       |    10    |
  CYST,PERIOVARIAN TISSUE                   | X  X     X  X                       X        X  X  X     X     X          |    16    |
  HEMATOCYST                                |          X              X           X  X                 X                |     7    |
  HYPERPLASIA,ADENOMATOUS                   |                                                                           |     2 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          3  1        2  2                                 |     5 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |     2                                                                     |     1 2.0|
  ATROPHY                                   |                                                                           |     2 3.5|
  DILATATION                                |  4                                                                        |     2 3.5|
  FIBROSIS                                  |              2                                                            |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |     2     3  3  2  3  2  2  2  1  2  2  3  2  3  3  2  2  1     2         |    37 2.2|
  PROLAPSE                                  |       X                                                                   |     1    |
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |                                                                           |     2 3.5|
  DYSPLASIA                                 |                       2                                                   |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1  2              1                              |     3 1.3|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |              2                                                            |     3 2.6|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   10
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HEMORRHAGE                                |                    2                 2        2                           |     3 2.0|
  HYPERPLASIA,LYMPHOID                      |              3     3                             2                        |     7 2.2|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                    2                                                      |     2 2.0|
  HEMORRHAGE                                |     3                                         1     2     1               |     4 1.7|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     2 2.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                                                           |     2 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                       2                                                   |     4 2.7|
  HYPERPLASIA,LYMPHOID                      |        1  1  3  1  3     2  3                 4                           |    13 2.1|
THYMUS                                      | +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +       | 41       |
  ATROPHY,CORTEX                            |  3     4  4     3        3     2        3        2  3  2  2  2  2         |    30 3.0|
  CONGESTION                                |                                                                           |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |     3        2           4              2  2        3        1            |    14 2.2|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  INFLAMMATION                              |                                            1                              |     1 1.0|
  LACTATION                                 |                                            2           2                  |     4 2.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROUS OSTEODYSTROPHY                    |  2        2  2        1  2  1     2  1     2  2  2     1                  |    18 1.8|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  2     3  2  3  1  3  3  2  2  1  1  1  4        3  2  3  4  1     1      |    36 2.1|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.5|
  POLYARTERITIS                             |     2                                                                     |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   11
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 2.0|
  THROMBUS                                  |                                                                           |     1 3.0|
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 2.0|
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1           1  2  1  1     1     1  2  1  2  1     1  1  1  1  1  1      |    28 1.1|
  THROMBUS                                  |                                                                           |     1 3.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 3.0|
  THROMBUS                                  |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1                                                |     1 1.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FOREIGN BODY                              |                                                                           |     1    |
  HEMORRHAGE                                |                       2        2                                          |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  1  2  1  1  1  2  2  3  1  2  2  1  1  1  2  1  1  1  1  1         |    37 1.3|
  INFLAMMATION                              |                       1                                                   |     4 2.5|
  THROMBUS                                  |                                                                           |     1 4.0|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CYST,NASOLACRIMAL DUCT                    |                 2                                                         |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 3.0|
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  INFLAMMATION                              |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 41       |
  DEGENERATION,RETINA                       |                                      4                                    |     1 4.0|
  THROMBUS                                  |                                                                           |     1 3.0|
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   12
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:45.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 9| 9| 3| 3| 3| 3| 3| 3| 1| 1| 1| 1| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|         U  V   I|
CONTRL F2YR   01     1                      | 3| 4| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 0| 1| 2| 3| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1  1           1  1     1  1     1     1  2     1         |    18 1.0|
  THROMBUS                                  |                                                                           |     1 2.0|
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M       | 41       |
  ATROPHY                                   |                                                                           |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1  2  1  2        2  1  1        1     1        1     1         |    25 1.2|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +       | 43       |
  INFLAMMATION                              |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                           2               |     2 2.5|
  CONGESTION                                |                                                                           |     1 1.0|
  CYST,RENAL TUBULE                         |           1           1     2     1        1     1        1  1     1      |    14 1.1|
  HYDRONEPHROSIS,BILATERAL                  |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  2  2  1  1     1  1  1  1  1  1  1  1  1  1  2  1     1  1         |    39 1.2|
  INFLAMMATION                              |                                                           1               |     1 1.0|
  NEPHROPATHY                               |                                                                           |     3 1.0|
  POLYARTERITIS                             |     2                                                                     |     1 2.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  1  1  1  2  2  1  1  1  1  1  1  2     1  1  1  1         |    38 1.1|
  POLYARTERITIS                             |     2                                                                     |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   13
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  M                    +  +                               |          |
GALLBLADDER                                 | +  +  +  +  +  +  M                    +  +                               |          |
INTESTINE LARGE                             | +  A  +  +  +  +  +                    +  +                               |          |
INTESTINE LARGE,CECUM                       | +  A  +  A  +  +  A                    +  +                               |          |
INTESTINE LARGE,COLON                       | +  A  +  +  +  +  +                    +  +                               |          |
INTESTINE LARGE,RECTUM                      | +  A  +  M  +  +  +                    +  +                               |          |
INTESTINE SMALL                             | +  A  +  A  +  +  A                    +  +                               |          |
INTESTINE SMALL,DUODENUM                    | +  A  +  A  +  +  A                    +  +                               |          |
INTESTINE SMALL,ILEUM                       | +  A  +  A  +  +  A                    +  +                               |          |
INTESTINE SMALL,JEJUNUM                     | +  A  +  A  +  +  A                    +  +                               |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                               1                           |          |
  BASOPHILIC FOCUS                          |                            X                                              |          |
  CLEAR CELL FOCUS                          |                                                 X                         |          |
  EOSINOPHILIC FOCUS                        |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  1  1  1        1                       1     1     1           1  1      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1     2  1  1  2  1  3  1     2  1  2  1  1  2  1  1      |          |
  NECROSIS                                  |     1        1        1  1  1  1  1  1        1  1  1  1  1     1  2  1  1|          |
  TENSION LIPOIDOSIS                        |                         X  X     X           X        X     X     X       |          |
  VACUOLIZATION CYTOPLASMIC                 |  2     2     3        3  2  3  1        2  1  1  1  1  2  2  2        1  1|          |
MESENTERY                                   |                                                                           |          |
  NECROSIS,FAT                              |                                                                           |          |
PANCREAS                                    | M  +  +  A  +  +  +                    +  +                               |          |
  ATROPHY                                   |                 1                                                         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1                             1                              |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +                    +  +                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1  1                       1  1                              |          |
STOMACH                                     | +  +  +  +  +  +  +                    +  +                               |          |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +                    +  +                               |          |
  HYPERKERATOSIS                            |           2        2                    2                                 |          |
  ULCER                                     |                                            2                              |          |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +                    +  +                               |          |
  MINERALIZATION                            |                                         2                                 |          |
TONGUE                                      | +  +  +  +  +  +  +                    A  +                               |          |
  INFLAMMATION                              |        2                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   14
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  M  +  +  +                    +  +                               |          |
BLOOD VESSEL,AORTA                          | +  +  +  M  +  +  +                    +  +                               |          |
  MINERALIZATION                            |                                         4                                 |          |
HEART                                       | +  +  +  +  +  +  +                    +  +                               |          |
  DEGENERATION                              |                                                                           |          |
  DILATATION                                |                 3                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  M  +  +  +  +  +                    +  +                               |          |
ADRENAL GLAND,CORTEX                        | +  M  +  +  +  +  +                    +  +                               |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  2  1  2                       2  2                              |          |
ADRENAL GLAND,MEDULLA                       | +  M  +  +  +  +  +                    +  +                               |          |
ISLETS, PANCREATIC                          | M  +  +  A  +  +  +                    +  +                               |          |
PARATHYROID GLAND                           | M  +  +  +  +  +  +                    +  +                               |          |
PITUITARY GLAND                             | M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                     1  1           1      |          |
THYROID GLAND                               | M  +  +  +  +  +  +                    +  +                               |          |
  CYST,FOLLICLE                             |                                            2                              |          |
  DEGENERATION                              |                                                                           |          |
  HYPERPLASIA,FOLLICULAR CELL               |                    4                                                      |          |
  ULTIMOBRANCHIAL CYST                      |                 3                       3                                 |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | M  M  +  +  +  +  +                    +  +                               |          |
  ATROPHY                                   |           3     4  4                    3  3                              |          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +                |          |
  ATROPHY                                   | X  X  X        X                       X  X                               |          |
  CYST                                      |          X  X        X           X  X              X  X                   |          |
  CYST,PERIOVARIAN TISSUE                   |    X                       X  X                          X                |          |
  HEMATOCYST                                |                         X           X                                     |          |
  MINERALIZATION                            |                          4                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   15
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

UTERUS                                      | +  +  +  +  +  +  +              +     +  +        +  +     +     +       |          |
  ATROPHY                                   |  3        4     4  4                    2                                 |          |
  DILATATION                                |                                                                           |          |
  FIBROSIS                                  |                                   2                                       |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2                    3                 3  3     2     2      |          |
  INFLAMMATION                              |        4                                                                  |          |
VAGINA                                      | +  +  +  +  +  M  +                    +  +                               |          |
  ATROPHY                                   |           4        4                    2                                 |          |
  DYSPLASIA                                 |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +                    +  +                               |          |
  HYPERPLASIA                               |  4  3  3                                2                                 |          |
LYMPH NODE                                  | +  +  +  +  +  +  +                    +  +                               |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +                    +  +                               |          |
  HEMORRHAGE                                |     2     2     2                                                         |          |
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                            3                              |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  M  +  A                    +  +                               |          |
  ATROPHY                                   |                                         4  3                              |          |
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |          |
SPLEEN                                      | +  +  +  +  +  +  +        +           +  +  +                            |          |
  ATROPHY                                   |                 3                       2                                 |          |
  CONGESTION                                |                                            1                              |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  4  4           4                                                         |          |
  HYPERPLASIA,LYMPHOID                      |              1              2           2     1                           |          |
THYMUS                                      | +  M  M  +  +  +  M                    M  +                               |          |
  ATROPHY,CORTEX                            |              3  4                          4                              |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |              2                                                            |          |
  INFLAMMATION                              |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  +  M  +  +  +                    +  +                               |          |
  HYPERPLASIA                               |        3                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   16
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

  LACTATION                                 |                    2                                                      |          |
SKIN                                        | +  +  +  +  +  +  +                    +  +                               |          |
  EDEMA                                     |                 3                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +                    +  +                               |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +                    +  +                               |          |
BONE,STERNUM                                | +  +  +  +  +  +  +                    +  +                               |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |        2                                1  1                              |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +                    A  +                    +          |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              2                                                            |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +                    +  +                               |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +                    +  +                               |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +                    +  +                               |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1  1     1                                                         |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +                    A  +                               |          |
SPINAL CORD                                 | +  +  +  +  +  +  +                    +  +                               |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +                    +  +                               |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  M  M  +  +  M  M                    +  +                               |          |
  INFLAMMATION                              |  1                                                                        |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,ALVEOLUS                      |                                                                          1|          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2  1     1     1  1  2     1  1  1        1  1  2  1     1            |          |
  LEUKOCYTOSIS                              |  3                                                                        |          |
  MINERALIZATION                            |                                         2                                 |          |
  THROMBUS                                  |                                      2                                    |          |
NOSE                                        | +  +  +  +  +  +  +                    +  +                               |          |
  MINERALIZATION,NASOLACRIMAL DUCT          |                                            3                              |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   17
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:51.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 6| 6| 6| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 2| 2| 9| 6| 3| 9| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 1| 8| 8| 3| 7| 9| 6| 6| 6| 6| 6| 6| 6| 1| 5| 5| 5| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 7| 7| 9| 7| 9| 1| 5| 5| 5| 6| 6| 6| 2| 2| 2| 2| 2| 6| 6| 6| 8| 8| 8| 8|   U  V   I|
25MG   F2YR   02     2                      | 2| 4| 6| 7| 8| 0| 7| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 3| 4| 5| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

TRACHEA                                     | +  +  +  +  +  +  +                    +  +                               |          |
  INFLAMMATION                              |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  A  +  A  +  +  A                    A  +                               |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +                    A  +                               |          |
LACRIMAL GLAND                              | +  +  +  +  +  M  M                    M  +                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1                                                            |          |
ZYMBAL'S GLAND                              | +  M  +  M  +  M  M                    +  +                               |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  A                    +  +                               |          |
  ACCUMULATION HYALINE DROPLET              |     2           2                                                         |          |
  CYST,RENAL TUBULE                         |     2  1                                                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1  1  1                          1                              |          |
  MINERALIZATION                            |                                         3                                 |          |
  NEPHROPATHY                               |                                         1                                 |          |
URINARY BLADDER                             | +  +  +  +  +  +  +                    +  +                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1  1     1                    1  1                              |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   18
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   |                                           +                               |  9       |
GALLBLADDER                                 |                                           M                               |  8       |
INTESTINE LARGE                             |                                           +                               |  9       |
INTESTINE LARGE,CECUM                       |                                           A                               |  6       |
INTESTINE LARGE,COLON                       |                                           +                               |  9       |
INTESTINE LARGE,RECTUM                      |                                           +                               |  8       |
INTESTINE SMALL                             |                                           +                               |  7       |
INTESTINE SMALL,DUODENUM                    |                                           +                               |  7       |
INTESTINE SMALL,ILEUM                       |                                           A                               |  6       |
INTESTINE SMALL,JEJUNUM                     |                                           A                               |  6       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |                                                  1                        |     2 1.0|
  BASOPHILIC FOCUS                          |                                                 X                         |     2    |
  CLEAR CELL FOCUS                          |                                                                           |     1    |
  EOSINOPHILIC FOCUS                        |                      X                                                    |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |  1                                   1                 1     1            |    13 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     3  1  2     1  1  1  1  1  1  1  1  1           1  1  1  1  1  1      |    35 1.2|
  NECROSIS                                  |  1  1     1     1  1  1  1  1     1  1  1     1     1  1  1  1  1  1      |    35 1.0|
  TENSION LIPOIDOSIS                        | X  X                 X                             X     X  X             |    13    |
  VACUOLIZATION CYTOPLASMIC                 |  1  1  1  1     2  2  1     1  2  2  2  1        2  2  2  2  2  2  2      |    36 1.6|
MESENTERY                                   |                            +                                              |  1       |
  NECROSIS,FAT                              |                             3                                             |     1 3.0|
PANCREAS                                    |                                           +                               |  8       |
  ATROPHY                                   |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     3 1.0|
SALIVARY GLANDS                             |                                  +        M                               | 10       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     6 1.0|
STOMACH                                     |                                           +                               | 10       |
STOMACH,FORESTOMACH                         |                                           +                               | 10       |
  HYPERKERATOSIS                            |                                                                           |     3 2.0|
  ULCER                                     |                                                                           |     1 2.0|
STOMACH,GLANDULAR                           |                                           +                               | 10       |
  MINERALIZATION                            |                                                                           |     1 2.0|
TONGUE                                      |                                           +                               |  9       |
  INFLAMMATION                              |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   19
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                |                                           M                               |  8       |
BLOOD VESSEL,AORTA                          |                                           M                               |  8       |
  MINERALIZATION                            |                                                                           |     1 4.0|
HEART                                       |                                           +                               | 10       |
  DEGENERATION                              |                                            2                              |     1 2.0|
  DILATATION                                |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               |                                           +                               |  9       |
ADRENAL GLAND,CORTEX                        |                                           +                               |  9       |
  HYPERPLASIA,SPINDLE CELL                  |                                                                           |     6 1.8|
ADRENAL GLAND,MEDULLA                       |                                           +                               |  9       |
ISLETS, PANCREATIC                          |                                           +                               |  8       |
PARATHYROID GLAND                           |                                           +                               |  9       |
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ANGIECTASIS                               |                                      1                                    |     1 1.0|
  DEGENERATION,CYSTIC,PARS DISTALIS         |                       1              1                                    |     2 1.0|
  HYPERPLASIA,PARS DISTALIS                 |     1  1                 1                                                |     6 1.0|
THYROID GLAND                               |                                           +                               |  9       |
  CYST,FOLLICLE                             |                                                                           |     1 2.0|
  DEGENERATION                              |                                            2                              |     1 2.0|
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |     1 4.0|
  ULTIMOBRANCHIAL CYST                      |                                                                           |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              |                                           +                               |  8       |
  ATROPHY                                   |                                            4                              |     6 3.5|
OVARY                                       | +                 +  +  +  +        +  +  +              +  +  +          | 29       |
  ATROPHY                                   |                                           X                               |     7    |
  CYST                                      | X                 X  X  X           X  X                    X  X          |    15    |
  CYST,PERIOVARIAN TISSUE                   |                                                          X                |     5    |
  HEMATOCYST                                |                            X                                              |     3    |
  MINERALIZATION                            |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   20
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

UTERUS                                      | +        +        +  +  +     +  +     +  A     +  +     +     +          | 26       |
  ATROPHY                                   |                                                                           |     5 3.4|
  DILATATION                                |                                         4           2                     |     2 3.0|
  FIBROSIS                                  |                                                                           |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2        4        4  4  3     2  2              3        2     2         |    16 2.6|
  INFLAMMATION                              |                                                                           |     1 4.0|
VAGINA                                      |                                           +                               |  9       |
  ATROPHY                                   |                                            3                              |     4 3.2|
  DYSPLASIA                                 |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 |                                           +                               | 10       |
  HYPERPLASIA                               |                                            4                              |     5 3.2|
LYMPH NODE                                  |       +     +                    +        +                               | 13       |
LYMPH NODE,MANDIBULAR                       |                                  +        +                               | 11       |
  HEMORRHAGE                                |                                                                           |     3 2.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       |             +                             +                               |  9       |
  ATROPHY                                   |                                                                           |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
SPLEEN                                      |             +                             +  +                            | 14       |
  ATROPHY                                   |                                                                           |     2 2.5|
  CONGESTION                                |                                                                           |     1 1.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     3 4.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     4 1.5|
THYMUS                                      |                                           M                               |  5       |
  ATROPHY,CORTEX                            |                                                                           |     3 3.6|
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                                                           |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               |                                           M                               |  6       |
  HYPERPLASIA                               |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   21
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

  LACTATION                                 |                                                                           |     1 2.0|
SKIN                                        |                                           +                               | 10       |
  EDEMA                                     |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        |                                           +                               | 10       |
BONE,FEMUR                                  |                                           +                               | 10       |
BONE,STERNUM                                |                                           +                               | 10       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                                                                           |     3 1.3|
SKELETAL MUSCLE                             |       +                                   +                               | 11       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       |                                           +                               | 10       |
BRAIN,CEREBELLUM                            |                                           +                               | 10       |
BRAIN,CEREBRUM                              |                                           +                               | 10       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                                                                           |     3 1.0|
PERIPHERAL NERVE                            |                                           +                               |  9       |
SPINAL CORD                                 |                                           +                               | 10       |
SPINAL CORD,THORACIC                        |                                           +                               | 10       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      |                                           M                               |  5       |
  INFLAMMATION                              |                                                                           |     1 1.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA,ALVEOLUS                      |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                            2                    1         |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1           1  1     1  2     1           1  1              1      |    24 1.1|
  LEUKOCYTOSIS                              |                                                                           |     1 3.0|
  MINERALIZATION                            |                                                                           |     1 2.0|
  THROMBUS                                  |                       1                                                   |     2 1.5|
NOSE                                        |                                           +                               | 10       |
  MINERALIZATION,NASOLACRIMAL DUCT          |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   22
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:53.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 8| 8| 8| 7| 7| 7| 7| 7| 7| 2| 2| 3| 3| 3| 3| 3| 0| 0| 0| 0| 0| 0| 0|         U  V   I|
25MG   F2YR   02     2                      | 7| 8| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

TRACHEA                                     |                                           M                               |  9       |
  INFLAMMATION                              |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         |                                           A                               |  4       |
HARDERIAN GLAND                             |                                        +  +                               | 10       |
LACRIMAL GLAND                              |                                           M                               |  6       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     3 1.0|
ZYMBAL'S GLAND                              |                                           +                               |  6       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      |             +                             +                               | 10       |
  ACCUMULATION HYALINE DROPLET              |                                            3                              |     3 2.3|
  CYST,RENAL TUBULE                         |                                                                           |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     5 1.0|
  MINERALIZATION                            |                                                                           |     1 3.0|
  NEPHROPATHY                               |                                                                           |     1 1.0|
URINARY BLADDER                             |                                           +                               | 10       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     6 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   23
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | M  +  +  +                                                                |          |
GALLBLADDER                                 | +  M  +  +                                                                |          |
INTESTINE LARGE                             | +  +  A  +                                                                |          |
INTESTINE LARGE,CECUM                       | +  +  A  +                                                                |          |
INTESTINE LARGE,COLON                       | +  +  A  +                                                                |          |
INTESTINE LARGE,RECTUM                      | +  +  A  +                                                                |          |
INTESTINE SMALL                             | +  +  A  +                                                                |          |
INTESTINE SMALL,DUODENUM                    | +  +  A  +                                                                |          |
INTESTINE SMALL,ILEUM                       | +  +  A  +                                                                |          |
INTESTINE SMALL,JEJUNUM                     | +  +  A  +                                                                |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                      X                                                    |          |
  CYST,BILE DUCT                            |                                                                           |          |
  DEGENERATION                              |     3                                                                     |          |
  EOSINOPHILIC FOCUS                        |                   X                          X     X                      |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  1  1           1                 1        1                 1     1      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1  1     1  1  3  3     1  2  2     1  1  2  1  1  2  1  1  1  2|          |
  NECROSIS                                  |  1              2  1           1     1     1  1  1  1  1  1  1  1     1  1|          |
  NECROSIS,COAGULATIVE                      |     3  1                                                                  |          |
  REGENERATION                              |     3                                                                     |          |
  TENSION LIPOIDOSIS                        |                         X  X     X     X        X  X  X                 X |          |
  VACUOLIZATION CYTOPLASMIC                 |  1        3     2           1  2                 1     2  2  2  2     1  2|          |
MESENTERY                                   |                                                                           |          |
  NECROSIS,FAT                              |                                                                           |          |
PANCREAS                                    | +  +  +  +                                                                |          |
  FOCAL CELLULAR CHANGE                     |  1        1                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                                  |          |
  POLYARTERITIS                             |  4                                                                        |          |
SALIVARY GLANDS                             | +  +  +  +                                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1                                                                  |          |
  POLYARTERITIS                             |  2                                                                        |          |
STOMACH                                     | +  +  A  +                                                                |          |
STOMACH,FORESTOMACH                         | +  +  A  +                                                                |          |
STOMACH,GLANDULAR                           | +  +  A  +                                                                |          |
  CYST                                      |     2                                                                     |          |
TONGUE                                      | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   24
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  POLYARTERITIS                             |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +                                                                |          |
BLOOD VESSEL,AORTA                          | +  +  +  +                                                                |          |
HEART                                       | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +                                                                |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +                                                                |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  2                                                               |          |
ADRENAL GLAND,MEDULLA                       | M  +  +  +                                                                |          |
ISLETS, PANCREATIC                          | +  +  +  +                                                                |          |
  HYPERPLASIA                               |                                                                           |          |
PARATHYROID GLAND                           | M  M  +  +                                                                |          |
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ANGIECTASIS                               |                                                                           |          |
  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                                           |          |
THYROID GLAND                               | +  +  +  +                                                                |          |
  POLYARTERITIS                             |  4                                                                        |          |
  ULTIMOBRANCHIAL CYST                      |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  M  M                                                        +       |          |
  ATROPHY                                   |  4  3                                                              3      |          |
OVARY                                       | M  +  +  +        +              +              +     +  +     +     +  + |          |
  ATROPHY                                   |                                                                           |          |
  CYST                                      |    X     X        X              X              X        X              X |          |
  CYST,PERIOVARIAN TISSUE                   |                                                       X        X          |          |
  HEMATOCYST                                |       X                                                                   |          |
  HYPERPLASIA,ADENOMATOUS                   |        3                                                                  |          |
UTERUS                                      | +  +  +  +  +  +        +  +        +     +     +     +     +     +     + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   25
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  ANGIECTASIS                               |                                            4                              |          |
  ATROPHY                                   |  2  3                                                                     |          |
  DILATATION                                |                                                                    4      |          |
  FIBROSIS                                  |           2                                                               |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |           2  3  2        3  3        2     3     2     2     2           3|          |
VAGINA                                      | +  +  +  +                                                                |          |
  ATROPHY                                   |     3                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +                                                                |          |
LYMPH NODE                                  | +  +  +  +           +           +                                        |          |
  HYPERPLASIA,LYMPHOID,INGUINAL             |  3                                                                        |          |
  HYPERPLASIA,LYMPHOID,THORACIC             |  3                                                                        |          |
LYMPH NODE,MANDIBULAR                       | +  +  M  +           +                                                    |          |
  HYPERPLASIA,LYMPHOID                      |  3                                                                        |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +                       +                                        |          |
  HEMORRHAGE                                |        2                                                                  |          |
  HYPERPLASIA,LYMPHOID                      |  3  2                                                                     |          |
  POLYARTERITIS,ARTERY                      |  4                                                                        |          |
SPLEEN                                      | +  +  +  +           +           +        +     +     +  +           +    |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  2  3  3                                                              3   |          |
  HYPERPLASIA,LYMPHOID                      |                                            2     1                        |          |
THYMUS                                      | +  +  +  +                       +                                        |          |
  ATROPHY,CORTEX                            |  4  4  4                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  +  +  +                                                                |          |
SKIN                                        | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +                                                                |          |
BONE,FEMUR                                  | +  +  +  +                                                                |          |
  POLYARTERITIS                             |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   26
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE,STERNUM                                | +  +  +  +                                                                |          |
SKELETAL MUSCLE                             | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +                                                                |          |
BRAIN,CEREBELLUM                            | +  +  +  +                                                                |          |
BRAIN,CEREBRUM                              | +  +  +  +                                                                |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1                                                                  |          |
  POLYARTERITIS                             |  4                                                                        |          |
PERIPHERAL NERVE                            | +  +  +  +                                                                |          |
SPINAL CORD                                 | +  +  +  +                                                                |          |
SPINAL CORD,THORACIC                        | +  +  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  M  M  +                                                                |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMORRHAGE                                |        3                                                                  |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                         2                                 |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1  1  1  1  1  1  1  1  1  1  1  1  1        2     1  1  1|          |
  THROMBUS                                  |                             1                                             |          |
NOSE                                        | +  +  +  +                                                                |          |
TRACHEA                                     | M  +  +  +                                                                |          |
  ECTASIA,GLANDS                            |     2                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +                                                                |          |
HARDERIAN GLAND                             | +  +  +  +                                                                |          |
  INFLAMMATION                              |                                                                           |          |
LACRIMAL GLAND                              | +  M  +  +                                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1                                                                  |          |
ZYMBAL'S GLAND                              | M  M  +  +                                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   27
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:57.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 2| 4| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 6| 7| 1| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 7| 7| 7| 7| 7| 7| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 8| 9| 0| 8| 6| 6| 6| 6| 6| 6| 6| 7| 3| 3| 3| 3| 6| 6| 0| 0| 0| 0| 0| 0| 7|   U  V   I|
50MG   F2YR   03     3                      | 9| 1| 1| 5| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 8| 9| 3| 4| 5| 6| 7| 8| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | +  +  +  +                                                                |          |
  ACCUMULATION HYALINE DROPLET              |        2                                                                  |          |
  CYST,RENAL TUBULE                         |  2     2  2                                                               |          |
  GLOMERULOSCLEROSIS                        |  3                                                                        |          |
  HYDRONEPHROSIS                            |     1                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  2  1                                                               |          |
  PIGMENTATION,RENAL TUBULE                 |     3                                                                     |          |
  POLYARTERITIS                             |  3                                                                        |          |
URINARY BLADDER                             | +  +  +  +                                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1  1  1                                                               |          |
  POLYARTERITIS                             |  4                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   28
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   |                      +                                                    |  4       |
GALLBLADDER                                 |                      +                                                    |  4       |
INTESTINE LARGE                             |                      A                                                    |  3       |
INTESTINE LARGE,CECUM                       |                      A                                                    |  3       |
INTESTINE LARGE,COLON                       |                      A                                                    |  3       |
INTESTINE LARGE,RECTUM                      |                      A                                                    |  3       |
INTESTINE SMALL                             |                   +  +                    +                               |  6       |
INTESTINE SMALL,DUODENUM                    |                      +                                                    |  4       |
INTESTINE SMALL,ILEUM                       |                      A                                                    |  3       |
INTESTINE SMALL,JEJUNUM                     |                      +                    +                               |  5       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                                                                           |     1    |
  CYST,BILE DUCT                            |                                                           2               |     1 2.0|
  DEGENERATION                              |                                                                           |     1 3.0|
  EOSINOPHILIC FOCUS                        |                                                       X                   |     4    |
  HEMATOPOIETIC CELL PROLIFERATION          |  1        1  1     1     1              1                 1     1  1      |    16 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1     1  1  2  1  2        1  1  1  2  2  1  1     1  1  1      |    40 1.3|
  NECROSIS                                  |        1  1  1  1  1           1  1  1  1     1  1  1  1  1  1     1      |    31 1.0|
  NECROSIS,COAGULATIVE                      |                                                                           |     2 2.0|
  REGENERATION                              |                                                                           |     1 3.0|
  TENSION LIPOIDOSIS                        |       X  X           X  X  X                       X           X  X       |    16    |
  VACUOLIZATION CYTOPLASMIC                 |        1     2  2  2  3  2  3  2  2  2     2  2  3  3  2  2     1  2      |    30 1.9|
MESENTERY                                   |                      +                                                    |  1       |
  NECROSIS,FAT                              |                       4                                                   |     1 4.0|
PANCREAS                                    |                      +                                                    |  5       |
  FOCAL CELLULAR CHANGE                     |                                                                           |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     2 1.0|
  POLYARTERITIS                             |                                                                           |     1 4.0|
SALIVARY GLANDS                             |                      +                                                    |  5       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     4 1.2|
  POLYARTERITIS                             |                                                                           |     1 2.0|
STOMACH                                     |                      +                                                    |  4       |
STOMACH,FORESTOMACH                         |                      +                                                    |  4       |
STOMACH,GLANDULAR                           |                      +                                                    |  4       |
  CYST                                      |                                                                           |     1 2.0|
TONGUE                                      |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   29
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  POLYARTERITIS                             |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                |                      +                                                    |  5       |
BLOOD VESSEL,AORTA                          |                      +                                                    |  5       |
HEART                                       |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               |                      +                                                    |  5       |
ADRENAL GLAND,CORTEX                        |                      +                                                    |  5       |
  HYPERPLASIA,SPINDLE CELL                  |                                                                           |     2 2.0|
ADRENAL GLAND,MEDULLA                       |                      M                                                    |  3       |
ISLETS, PANCREATIC                          |                      +                                                    |  5       |
  HYPERPLASIA                               |                       1                                                   |     1 1.0|
PARATHYROID GLAND                           |                      +                                                    |  3       |
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ANGIECTASIS                               |                                1                             1            |     2 1.0|
  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                        2                  |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |                 1        1     1                             1            |     4 1.0|
THYROID GLAND                               |                      +                                                    |  5       |
  POLYARTERITIS                             |                                                                           |     1 4.0|
  ULTIMOBRANCHIAL CYST                      |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              |                      +                                                    |  4       |
  ATROPHY                                   |                       4                                                   |     4 3.5|
OVARY                                       |       +     +  +     +        +     +     +  +     +  +                   | 21       |
  ATROPHY                                   |                      X                                                    |     1    |
  CYST                                      |                X              X     X     X  X     X                      |    13    |
  CYST,PERIOVARIAN TISSUE                   |             X                                         X                   |     4    |
  HEMATOCYST                                |       X                                                                   |     2    |
  HYPERPLASIA,ADENOMATOUS                   |                                                                           |     1 3.0|
UTERUS                                      | +     +  +  +        +  +           +  +        +  +  +  +     +  +       | 29       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   30
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  ANGIECTASIS                               |                                                                           |     1 4.0|
  ATROPHY                                   |                       4                                                   |     3 3.0|
  DILATATION                                |                                         4                                 |     2 4.0|
  FIBROSIS                                  |                                                                           |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2     2  2  4           2           2           3  3  3  2     2  4      |    23 2.5|
VAGINA                                      |                      +                                                    |  5       |
  ATROPHY                                   |                       3                                                   |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 |                      +                                                    |  5       |
LYMPH NODE                                  |                   +  +                                                    |  8       |
  HYPERPLASIA,LYMPHOID,INGUINAL             |                                                                           |     1 3.0|
  HYPERPLASIA,LYMPHOID,THORACIC             |                                                                           |     1 3.0|
LYMPH NODE,MANDIBULAR                       |                      +                                                    |  5       |
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       |                   +  +                                                    |  7       |
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     2 2.5|
  POLYARTERITIS,ARTERY                      |                                                                           |     1 4.0|
SPLEEN                                      |    +  +        +  +  +                    +  +                    +       | 19       |
  HEMATOPOIETIC CELL PROLIFERATION          |                                            1                              |     5 2.4|
  HYPERPLASIA,LYMPHOID                      |     3           2                                                  1      |     5 1.8|
THYMUS                                      |                      M                                                    |  5       |
  ATROPHY,CORTEX                            |                                                                           |     3 4.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               |                      +     +                                              |  5       |
SKIN                                        |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        |                      +                                                    |  5       |
BONE,FEMUR                                  |                      +                                                    |  5       |
  POLYARTERITIS                             |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   31
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE,STERNUM                                |                      +                                                    |  5       |
SKELETAL MUSCLE                             |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       |                      +                                                    |  5       |
BRAIN,CEREBELLUM                            |                      +                                                    |  5       |
BRAIN,CEREBRUM                              |                      +                                                    |  5       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                                                                           |     1 1.0|
  POLYARTERITIS                             |                                                                           |     1 4.0|
PERIPHERAL NERVE                            |                      +                                                    |  5       |
SPINAL CORD                                 |                      +                                                    |  5       |
SPINAL CORD,THORACIC                        |                      +                                                    |  5       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      |                      M                                                    |  1       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HEMORRHAGE                                |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |              2                                                            |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  1  1  1     1  1           1              1           2     1      |    29 1.1|
  THROMBUS                                  |                                                                           |     1 1.0|
NOSE                                        |                      +                                                    |  5       |
TRACHEA                                     |                      +                                                    |  4       |
  ECTASIA,GLANDS                            |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         |                      +                                                    |  5       |
HARDERIAN GLAND                             |             +        +                                                    |  6       |
  INFLAMMATION                              |              2                                                            |     1 2.0|
LACRIMAL GLAND                              |                      +                                                    |  4       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     3 1.3|
ZYMBAL'S GLAND                              |                      +                                                    |  3       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   32
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:34:59.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 0| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 7| 8| 8| 8| 8| 8| 1| 4| 4| 4| 4| 4| 4| 4| 0| 1| 1| 1| 1| 1| 1| 1|         U  V   I|
50MG   F2YR   03     3                      | 8| 9| 0| 1| 2| 3| 4| 0| 0| 1| 2| 3| 4| 5| 6| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      |                      +                                                    |  5       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     1 2.0|
  CYST,RENAL TUBULE                         |                       1                                                   |     4 1.7|
  GLOMERULOSCLEROSIS                        |                                                                           |     1 3.0|
  HYDRONEPHROSIS                            |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     4 1.2|
  PIGMENTATION,RENAL TUBULE                 |                                                                           |     1 3.0|
  POLYARTERITIS                             |                                                                           |     1 3.0|
URINARY BLADDER                             |                      +                                                    |  5       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     5 1.2|
  POLYARTERITIS                             |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   33
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:14.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |        3                                                                  |          |
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2           1                  |          |
INTESTINE LARGE                             | +  +  A  +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  A  +  A  +  A  +  +  +  +  A  M  A  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |           2                                                               |          |
INTESTINE LARGE,COLON                       | +  +  A  +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE SMALL                             | +  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
INTESTINE SMALL,ILEUM                       | A  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
  INFLAMMATION                              |                                                                           |          |
INTESTINE SMALL,JEJUNUM                     | A  +  A  +  A  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  CONGESTION                                |  1                                                                        |          |
  EOSINOPHILIC FOCUS                        |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                 1     1     1                                             |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1     1  1  1        1  1  1  3  1  1  1  1     1  1  1  1|          |
  INFLAMMATION                              |                                                                           |          |
  MINERALIZATION                            |                                                                           |          |
  NECROSIS                                  |                             1     1  1        2  1  1  1     1  1     1  1|          |
  TENSION LIPOIDOSIS                        |                         X  X        X              X  X     X             |          |
  VACUOLIZATION CYTOPLASMIC                 |           2           1  1  1        1                 1           1  2  1|          |
MESENTERY                                   |                                                                           |          |
  NECROSIS,FAT                              |                                                                           |          |
PANCREAS                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTASIA,DUCT                              |                                                        1                  |          |
  FOCAL CELLULAR CHANGE                     |  1                                                        2               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1  1  1              2  1  1           1  1     1  1|          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   34
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:14.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |                       2                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1  1        1  1  1  1  1  1  2  2  2  1  2  1  2  1  2  1  2|          |
STOMACH                                     | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  A  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |  2                 2                                                      |          |
STOMACH,GLANDULAR                           | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                                     1                     |          |
  MINERALIZATION                            |                                                                           |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |  2                                                                        |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                                           |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTOPIC TISSUE                            |                                                                   X       |          |
  HYPERPLASIA                               |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  3  2  2     2  2  2  1  2  2     3  2  2  2  2  2  1  2  3  1  2|          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                           1               |          |
  VACUOLIZATION CYTOPLASMIC                 |                       1                                                   |          |
ISLETS, PANCREATIC                          | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                          1                                                |          |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M |          |
  CYST                                      |                                                                           |          |
  ECTOPIC THYMUS                            |                                              X        X                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   35
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:14.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
PITUITARY GLAND                             | M  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  HEMORRHAGE                                |     2                                                                     |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                           3           2  2|          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CRYSTALS                                  |                                                                           |          |
  DEGENERATION                              |                                               2                           |          |
  ECTOPIC THYMUS                            |                                                                           |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                           2              2|          |
  ULTIMOBRANCHIAL CYST                      |                 2                    2                    3               |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           3  1  3  2  4  4  3  3  3  3     3  3  3     3  3  3  3     3  3|          |
OVARY                                       | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   | X           X  X     X  X     X  X  X  X        X  X  X  X     X  X  X  X |          |
  CYST                                      |                            X           X     X              X     X       |          |
  CYST,PERIOVARIAN TISSUE                   |                               X     X        X  X  X     X  X        X  X |          |
  HEMATOCYST                                |                                           X     X                         |          |
  HYPERPLASIA,ADENOMATOUS                   |                                                                           |          |
  HYPERPLASIA,TUBULAR                       |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                  3                        |          |
  MINERALIZATION                            |                                                                           |          |
  POLYARTERITIS                             |                                                                           |          |
UTERUS                                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |  3                       3                                                |          |
  FIBROSIS                                  |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |           3  2  1     2     3  4  2  4     2     3  3  2  2     2  4     3|          |
  HYPERTROPHY,MYOMETRIUM                    |                                                              2            |          |
  METAPLASIA,SQUAMOUS                       |                                                                           |          |
  PROLAPSE                                  |                                                                   X       |          |
VAGINA                                      | +  +  +  M  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                          3     2                                          |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   36
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:14.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  DYSPLASIA                                 |                                            2                       2      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |           4        4                    3           3                     |          |
LYMPH NODE                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION,INGUINAL |                                                                           |          |
  HEMORRHAGE,INGUINAL                       |                                                                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC,INGUINAL|                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                                                              2            |          |
  HYPERPLASIA,PLASMA CELL                   |              3                                                            |          |
LYMPH NODE,MESENTERIC                       | A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  + |          |
  ATROPHY                                   |     4                                                                     |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |          |
SPLEEN                                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                           |          |
  CONGESTION                                |  3           1                                                        1   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |           3  3                          3                             3   |          |
  HYPERPLASIA,LYMPHOID                      |                                            2     3           1        1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFILTRATION CELLULAR,PLASMA CELL         |              2                                                            |          |
  INFLAMMATION                              |                                                                           |          |
THYMUS                                      | M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,CORTEX                            |        4  3  2  4           3     2  4     2  3  2  2  3  3  3  4  2     2|          |
  CYST                                      |                                                                           |          |
  ECTOPIC PARATHYROID GLAND                 |                            X                                              |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                             2     2        3  2        2     2     2     2|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   37
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:15.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  A  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                          2           3     3  2                           |          |
  LACTATION                                 |                                                                           |          |
SKIN                                        | +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,CARTILAGE                    |                                                                           |          |
  FIBROUS OSTEODYSTROPHY                    |                          3                                2               |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                 1           4        1        2  3  3  3  3  3  3  2  2   |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |              1  1  1        1           1        1     1  2  2            |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
SPINAL CORD                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEVELOPMENTAL MALFORMATION                |                                                                          2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            1                              |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                        3                  |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   38
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:15.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 0| 1| 5| 6| 6| 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 8| 6| 3| 3| 9| 0| 5| 5| 5| 5| 1| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 9| 6| 9| 8| 1| 2| 6| 6| 6| 4| 1| 0| 1| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 6|   S  R   R|
                                            | 0| 2| 6| 7| 8| 9| 0| 2| 2| 2| 7| 8| 0| 2| 9| 9| 9| 9| 9| 0| 0| 2| 2| 3| 3|   U  V   I|
100MG  F2YR   04     4                      | 3| 0| 6| 8| 2| 9| 1| 4| 5| 6| 3| 6| 3| 8| 5| 6| 7| 8| 9| 0| 1| 8| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1           2        1  1     1        2  1  1  1     1  1  1     1  2|          |
  INFLAMMATION                              |  3                          2                                             |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYTOPLASMIC ALTERATION,RESPIRATORY EPITHEL|                                                                           |          |
    IUM                                     |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC,GLANDS  |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC,NASOLACR|                                                                           |          |
    IMAL DUCT                               |                                                                           |          |
TRACHEA                                     | +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTASIA,GLANDS                            |                                               2                           |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  A  +  A  A  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                          3                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1                             1                 1        1|          |
LACRIMAL GLAND                              | +  +  A  +  +  +  M  M  +  M  +  +  +  M  +  M  +  +  +  +  +  +  M  +  + |          |
  ATROPHY                                   |     2                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1                          2     2  2  1  1              1|          |
ZYMBAL'S GLAND                              | M  +  M  M  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET              |           3                    1                                          |          |
  AMYLOID DEPOSITION,GLOMERULUS             |     4                                                                     |          |
  CYST,RENAL TUBULE                         |     3     1     1        1  1        1        1           1           1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1  3        1  1  1  2  1     2  1  2  1  1  1  1  2  1  1  2|          |
  NECROSIS,RENAL TUBULE                     |                                                                           |          |
  PIGMENTATION,RENAL TUBULE                 |                                                                       2   |          |
URINARY BLADDER                             | A  +  M  M  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1        1  2     1  1     1  1  1  1  1  2  1     1  1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   39
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERKERATOSIS                            |                                                                           |     1 3.0|
GALLBLADDER                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                    1              1                                       |     4 1.2|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 41       |
  HYPERPLASIA,LYMPHOID                      |                             2        2                             2      |     4 2.0|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 43       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,LYMPHOID                      |                                2                                          |     1 2.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 42       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 42       |
  INFLAMMATION                              |                                                                 2         |     1 2.0|
INTESTINE SMALL,ILEUM                       | +  M  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 39       |
  HYPERPLASIA,LYMPHOID                      |                       2                                                   |     1 2.0|
  INFLAMMATION                              |                                                                 2         |     1 2.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 41       |
  INFLAMMATION                              |                                                                 2         |     1 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          | X                          X                                              |     2    |
  CONGESTION                                |                                                                           |     1 1.0|
  EOSINOPHILIC FOCUS                        |                                           X                               |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |        1                                                                  |     4 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  1  1     1  3  1     3     1  1  1     1  2  1  1  1      |    36 1.1|
  INFLAMMATION                              |                                                                 3         |     1 3.0|
  MINERALIZATION                            |                                                                 1         |     1 1.0|
  NECROSIS                                  |  1  2  1  1  1  1  1  1  1  1  1  1  2     1  1  1  1  1  1  1     1      |    32 1.0|
  TENSION LIPOIDOSIS                        | X                 X     X  X     X        X           X  X  X  X          |    16    |
  VACUOLIZATION CYTOPLASMIC                 |     1        2  1           1     1  1     1  1  2  2  1  1  1     2      |    23 1.2|
MESENTERY                                   |                +                                                          |  1       |
  NECROSIS,FAT                              |                 4                                                         |     1 4.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +       | 46       |
  ECTASIA,DUCT                              |                                                                           |     1 1.0|
  FOCAL CELLULAR CHANGE                     |                                                                           |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2           1     1  1           2           1  1  1     1            |    19 1.1|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   40
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |                                                           1               |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  2  1  1  2  1  2  1  1  1  1  1  1  1  1  2  1     2     1      |    41 1.2|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  HYPERKERATOSIS                            |                                                                           |     2 2.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  CYST                                      |                                                     1     1               |     3 1.0|
  MINERALIZATION                            |                    1                 1                                    |     2 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +       | 45       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +       | 45       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1                       1                        |     2 1.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
  POLYARTERITIS                             |                 2                                                         |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ACCESSORY ADRENAL CORTICAL NODULE         |                X                                                          |     1    |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ECTOPIC TISSUE                            |                                                    X                      |     2    |
  HYPERPLASIA                               |                 1                                                         |     1 1.0|
  HYPERPLASIA,SPINDLE CELL                  |  2  2  2  2  2  1  2  2  2  1  1  1  2  3  2  3  2  2  2  2  1  3  1      |    44 1.9|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA                               |                                                                 2         |     2 1.5|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 1.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA                               |                                                                           |     1 1.0|
PARATHYROID GLAND                           | +  +  +  +  +  M  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M       | 40       |
  CYST                                      |     2                                                                     |     1 2.0|
  ECTOPIC THYMUS                            |                                                                           |     2    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         3                                 |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   41
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  VACUOLIZATION CYTOPLASMIC                 |                                                                 2         |     1 2.0|
PITUITARY GLAND                             | +  M  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 41       |
  ANGIECTASIS                               |                                                  2                        |     1 2.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |  3              2        2  2     2                 2                     |     9 2.2|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CRYSTALS                                  |                          1                                                |     1 1.0|
  DEGENERATION                              |                                                                           |     1 2.0|
  ECTOPIC THYMUS                            |    X                                                                      |     1    |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |     2 2.0|
  ULTIMOBRANCHIAL CYST                      |        2     2     2        2     2        2           4                  |    10 2.3|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +       | 43       |
  ATROPHY                                   |  3  3     4  3  3  4  4  3  3  2     4  4     3  3  3  3  3  3     3      |    38 3.0|
OVARY                                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   | X        X  X  X  X     X  X  X  X  X     X  X     X  X  X  X  X  X       |    35    |
  CYST                                      | X     X     X                    X     X  X        X        X  X          |    14    |
  CYST,PERIOVARIAN TISSUE                   |          X           X  X  X  X                 X                         |    15    |
  HEMATOCYST                                |                                                 X                         |     3    |
  HYPERPLASIA,ADENOMATOUS                   |                                   4                                       |     1 4.0|
  HYPERPLASIA,TUBULAR                       |                       1                                      3            |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                           2               |     2 2.5|
  MINERALIZATION                            |                                      1                                    |     1 1.0|
  POLYARTERITIS                             |                 2                                                         |     1 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ANGIECTASIS                               |  3                                                                        |     1 3.0|
  ATROPHY                                   |                                                                           |     2 3.0|
  FIBROSIS                                  |                                                  2                        |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  4  3  3  2  2  2  2  2  2  2  2     2     3  2  2  2  2  2  2  2  2      |    37 2.4|
  HYPERTROPHY,MYOMETRIUM                    |                                                  3                        |     2 2.5|
  METAPLASIA,SQUAMOUS                       |                                                  2                        |     1 2.0|
  PROLAPSE                                  |                                                                           |     1    |
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  ATROPHY                                   |                                         4                                 |     3 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   42
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  DYSPLASIA                                 |                                                                           |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                        1                  |     2 1.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                          2              4                                 |     6 3.3|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HEMATOPOIETIC CELL PROLIFERATION          |                                         4                                 |     1 4.0|
  HEMATOPOIETIC CELL PROLIFERATION,INGUINAL |                                         4                                 |     1 4.0|
  HEMORRHAGE,INGUINAL                       |                                         2                                 |     1 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC,INGUINAL|                                         3                                 |     1 3.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HEMATOPOIETIC CELL PROLIFERATION          |                                         4                                 |     1 4.0|
  HYPERPLASIA,LYMPHOID                      |  2  2     2     2                    3     2  3        3                  |     9 2.3|
  HYPERPLASIA,PLASMA CELL                   |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 44       |
  ATROPHY                                   |                                                                           |     1 4.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                         3                                 |     1 3.0|
  HEMORRHAGE                                |              3                          4                                 |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |                 2                                      3                  |     2 2.5|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                         4                                 |     1 4.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                         2                                 |     1 2.0|
  CONGESTION                                |                                                                           |     3 1.6|
  HEMATOPOIETIC CELL PROLIFERATION          |  3     3        3                       4        2                        |     9 3.0|
  HYPERPLASIA,LYMPHOID                      |     3           1           1     1  1        1     4                     |    11 1.7|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1                                                               |     1 1.0|
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |     1 2.0|
  INFLAMMATION                              |                                                                 4         |     1 4.0|
THYMUS                                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ATROPHY,CORTEX                            |  3        3  4  3  2  2     3  2  3  3  2  3  3  3  4        3     3      |    34 2.8|
  CYST                                      |                                                           2               |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |  2        2     2  1  2              2           2     3  2               |    17 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   43
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERPLASIA                               |     2     1                                                        1      |     7 2.0|
  LACTATION                                 |                          2                                                |     1 2.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  DEGENERATION,CARTILAGE                    |                       2                                                   |     1 2.0|
  FIBROUS OSTEODYSTROPHY                    |           2              3     2  1        1        4        2     1      |    10 2.1|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |     2  2  2  1  3  4  1  2  2  2  3  1     2  2  3  3  2  3  4  3  2      |    33 2.3|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1     1     1  1  1  1           1     1  1           1  1  1     1      |    22 1.0|
PERIPHERAL NERVE                            | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  DEVELOPMENTAL MALFORMATION                |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  INFLAMMATION                              |                                                              2            |     1 2.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                        4                  |     1 4.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   44
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:29.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|         S  R   R|
                                            | 3| 9| 9| 9| 9| 9| 0| 0| 0| 4| 4| 4| 4| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3|         U  V   I|
100MG  F2YR   04     4                      | 2| 5| 6| 7| 8| 9| 0| 1| 2| 0| 1| 2| 3| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1           2  1  1           1  2  2  2  1  1  1  2  2        1      |    29 1.3|
  INFLAMMATION                              |                                                                           |     2 2.5|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CYTOPLASMIC ALTERATION,RESPIRATORY EPITHEL|                       1                                                   |     1 1.0|
    IUM                                     |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC,GLANDS  |                                                           1               |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC,NASOLACR|                                                           2               |     1 2.0|
    IMAL DUCT                               |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ECTASIA,GLANDS                            |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +       | 40       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1           1  1     1                                1  1  1      |    12 1.0|
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 40       |
  ATROPHY                                   |                             2        2                                    |     3 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1  1     1     1  2  1     1           1  1  1  1           1      |    20 1.2|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +       | 40       |
  INFLAMMATION                              |                                      2                                    |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     2 2.0|
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |     1 4.0|
  CYST,RENAL TUBULE                         |                    1           1  1        1  1  1     1           1      |    17 1.1|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  1     1  2  1  1  1  2  1  1  2  1  1  2  2  2  1           2      |    38 1.3|
  NECROSIS,RENAL TUBULE                     |                                                     1                     |     1 1.0|
  PIGMENTATION,RENAL TUBULE                 |                                                                           |     1 2.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  1  1  1     1  1  1  1     1  1  1  1  1  2  1     1      |    35 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   45
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:32.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|                                                      U  V   I|
CONTRL F3MTHR 05     5                      | 2| 3| 4| 5| 6| 7| 8| 9|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +                                                    |  8       |
  INFLAMMATION,MEDIASTINUM                  |                       4                                                   |     1 4.0|
GALLBLADDER                                 | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +                                                    |  8       |
LIVER                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1                                                               |     1 1.0|
  NECROSIS                                  |     1  1     1  1  1  1                                                   |     6 1.0|
PANCREAS                                    | +  +  +  +  +  +  +  +                                                    |  8       |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1           1  1  1                                                   |     5 1.0|
STOMACH                                     | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +                                                    |  8       |
TONGUE                                      | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  M  +                                                    |  7       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  M  +                                                    |  7       |
HEART                                       | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,SPINDLE CELL                  |        1  1     1     1                                                   |     4 1.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +                                                    |  8       |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +                                                    |  8       |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  M                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   46
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:32.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|                                                      U  V   I|
CONTRL F3MTHR 05     5                      | 2| 3| 4| 5| 6| 7| 8| 9|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

PITUITARY GLAND                             | +  +  +  +  +  +  +  +                                                    |  8       |
THYROID GLAND                               | +  +  +  +  +  +  +  M                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  M  +  +  +  +  +  +                                                    |  7       |
OVARY                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  CONGESTION                                |                    1                                                      |     1 1.0|
UTERUS                                      | +  +  +  +  +  +  +  +                                                    |  8       |
VAGINA                                      | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA                               |                       2                                                   |     1 2.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +                                                    |  8       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,LYMPHOID                      |     2                                                                     |     1 2.0|
LYMPH NODE,MESENTERIC                       | +  M  +  +  +  +  +  +                                                    |  7       |
  HYPERPLASIA,LYMPHOID                      |  3                                                                        |     1 3.0|
SPLEEN                                      | +  +  +  +  +  +  +  +                                                    |  8       |
THYMUS                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  CYST                                      |     1                                                                     |     1 1.0|
  INFLAMMATION,MEDIASTINUM                  |                    1                                                      |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
SKIN                                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,STERNUM                                | +  +  +  +  +  +  +  +                                                    |  8       |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   47
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:32.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|                                                      U  V   I|
CONTRL F3MTHR 05     5                      | 2| 3| 4| 5| 6| 7| 8| 9|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +                                                    |  8       |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M  M  M  M  M  +                                                    |  3       |
LUNG                                        | +  +  +  +  +  +  +  +                                                    |  8       |
  CONGESTION                                |     2                                                                     |     1 2.0|
  HEMORRHAGE                                |           1                                                               |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1                                                               |     1 1.0|
NOSE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
TRACHEA                                     | +  +  +  +  +  +  +  M                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +                                                    |  8       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +                                                    |  8       |
LACRIMAL GLAND                              | +  +  +  +  +  M  +  +                                                    |  7       |
ZYMBAL'S GLAND                              | +  +  +  +  +  M  +  +                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +                                                    |  8       |
URINARY BLADDER                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1                                                            |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   48
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:34.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 2| 2| 2| 2| 2| 2| 2| 2|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|                                                      U  V   I|
CONTRL F6MTHR 06     6                      | 1| 2| 3| 4| 5| 6| 7| 8|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | M  +  +  +  +  +  +  +                                                    |  7       |
GALLBLADDER                                 | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +                                                    |  8       |
LIVER                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1     1                                                         |     3 1.0|
  NECROSIS                                  |  1     2  1  1     1                                                      |     5 1.2|
  TENSION LIPOIDOSIS                        |                      X                                                    |     1    |
  VACUOLIZATION CYTOPLASMIC                 |  1        1  1  1     1                                                   |     5 1.0|
PANCREAS                                    | +  +  +  +  +  +  +  +                                                    |  8       |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1     1        1                                                   |     4 1.0|
STOMACH                                     | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +                                                    |  8       |
  INFLAMMATION                              |  1                                                                        |     1 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                    1                                                      |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  M  +  +  +                                                    |  7       |
BLOOD VESSEL,AORTA                          | +  +  +  +  M  +  +  +                                                    |  7       |
HEART                                       | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,SPINDLE CELL                  |  2  1        1     1                                                      |     4 1.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   49
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:35.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 2| 2| 2| 2| 2| 2| 2| 2|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|                                                      U  V   I|
CONTRL F6MTHR 06     6                      | 1| 2| 3| 4| 5| 6| 7| 8|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +                                                    |  8       |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +                                                    |  8       |
PARATHYROID GLAND                           | +  M  M  M  +  M  +  +                                                    |  4       |
  ECTOPIC THYMUS                            |             X                                                             |     1    |
PITUITARY GLAND                             | M  +  M  +  M  +  M  M                                                    |  3       |
THYROID GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +                                                    |  8       |
OVARY                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  CYST                                      |       X                                                                   |     1    |
  HEMATOCYST                                |       X                                                                   |     1    |
UTERUS                                      | +  +  +  +  +  +  +  +                                                    |  8       |
VAGINA                                      | +  +  +  +  M  +  +  +                                                    |  7       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1                                                         |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA                               |              3                                                            |     1 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +                                                    |  8       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +                                                    |  8       |
  FIBROSIS                                  |              3                                                            |     1 3.0|
  HYPERPLASIA,LYMPHOID                      |        2              2                                                   |     2 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +                                                    |  8       |
SPLEEN                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  CONGESTION                                |     2                                                                     |     1 2.0|
  HEMATOPOIETIC CELL PROLIFERATION          |              3                                                            |     1 3.0|
  HYPERPLASIA,LYMPHOID                      |     2                                                                     |     1 2.0|
THYMUS                                      | +  +  +  +  M  +  +  +                                                    |  7       |
  ATROPHY,CORTEX                            |        2              2                                                   |     2 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   50
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:35.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 2| 2| 2| 2| 2| 2| 2| 2|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|                                                      U  V   I|
CONTRL F6MTHR 06     6                      | 1| 2| 3| 4| 5| 6| 7| 8|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
SKIN                                        | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA                               |           2                                                               |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,STERNUM                                | +  +  +  +  +  +  +  +                                                    |  8       |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +                                                    |  8       |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  M  +  M  M  +  M  M                                                    |  3       |
LUNG                                        | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  1  1                                                      |     5 1.0|
NOSE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
TRACHEA                                     | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +                                                    |  8       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +                                                    |  8       |
LACRIMAL GLAND                              | +  +  M  +  M  +  +  +                                                    |  6       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1     1                                                   |     2 1.0|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  M  +                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   51
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:35.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 2| 2| 2| 2| 2| 2| 2| 2|
                                            | 1| 1| 1| 1| 1| 1| 1| 1|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|                                                      U  V   I|
CONTRL F6MTHR 06     6                      | 1| 2| 3| 4| 5| 6| 7| 8|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1        1                                                   |     2 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1  1                                                      |     2 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   52
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:37.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 3| 3| 3| 3| 3| 3| 3|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 4| 4| 4| 4| 4| 4| 4| 4|                                                      U  V   I|
CONTRL F12MTHR07     7                      | 0| 1| 2| 3| 4| 5| 6| 7|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERKERATOSIS                            |        2                                                                  |     1 2.0|
GALLBLADDER                                 | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     1 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE LARGE,COLON                       | +  +  +  +  M  +  +  +                                                    |  7       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +                                                    |  8       |
  CYST                                      |                 2                                                         |     1 2.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +                                                    |  8       |
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +                                                    |  8       |
LIVER                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1  1  1     1                                                   |     5 1.0|
  TENSION LIPOIDOSIS                        |    X           X                                                          |     2    |
  VACUOLIZATION CYTOPLASMIC                 |  1        1  1     1  1                                                   |     5 1.0|
MESENTERY                                   |                +                                                          |  1       |
PANCREAS                                    | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     2 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1  1  1  1  2                                                   |     7 1.1|
STOMACH                                     | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +                                                    |  8       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +                                                    |  8       |
TONGUE                                      | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +                                                    |  8       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +                                                    |  8       |
HEART                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  CARDIOMYOPATHY                            |     1                                                                     |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   53
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:38.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 3| 3| 3| 3| 3| 3| 3|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 4| 4| 4| 4| 4| 4| 4| 4|                                                      U  V   I|
CONTRL F12MTHR07     7                      | 0| 1| 2| 3| 4| 5| 6| 7|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

ADRENAL GLAND                               | M  +  +  +  +  +  +  +                                                    |  7       |
ADRENAL GLAND,CORTEX                        | M  +  +  +  +  +  +  +                                                    |  7       |
  HYPERPLASIA,SPINDLE CELL                  |     2  3  2  2  2  1                                                      |     6 2.0|
ADRENAL GLAND,MEDULLA                       | M  +  +  +  +  +  +  +                                                    |  7       |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +                                                    |  8       |
PARATHYROID GLAND                           | +  M  M  M  +  +  M  M                                                    |  3       |
PITUITARY GLAND                             | M  M  +  +  +  M  +  +                                                    |  5       |
THYROID GLAND                               | +  M  +  +  +  +  M  +                                                    |  6       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | M  +  +  +  +  M  +  +                                                    |  6       |
  ATROPHY                                   |     4  2  2        2  4                                                   |     5 2.8|
OVARY                                       | +  +  +  +  +  +  +  +                                                    |  8       |
  ATROPHY                                   |       X     X                                                             |     2    |
UTERUS                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  1     2                                                                  |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     1 1.0|
VAGINA                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1           1  1                                                   |     3 1.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA                               |                 3                                                         |     1 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +                                                    |  8       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,LYMPHOID                      |  2        2     2                                                         |     3 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +                                                    |  8       |
SPLEEN                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |     1 2.0|
THYMUS                                      | +  +  M  +  +  +  +  +                                                    |  7       |
  ATROPHY,CORTEX                            |  3        2  2                                                            |     3 2.3|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   54
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:38.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 3| 3| 3| 3| 3| 3| 3|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 4| 4| 4| 4| 4| 4| 4| 4|                                                      U  V   I|
CONTRL F12MTHR07     7                      | 0| 1| 2| 3| 4| 5| 6| 7|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +                                                    |  8       |
SKIN                                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +                                                    |  8       |
BONE,STERNUM                                | +  +  +  +  +  +  +  +                                                    |  8       |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +                                                    |  8       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +                                                    |  8       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1                                                                        |     1 1.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +                                                    |  8       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  +  +  +  +  +  +  M                                                    |  6       |
LUNG                                        | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2     1  1  1  1  1                                                   |     7 1.1|
NOSE                                        | +  +  +  +  +  +  +  +                                                    |  8       |
TRACHEA                                     | +  M  +  +  +  +  M  +                                                    |  6       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +                                                    |  8       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |     1 1.0|
LACRIMAL GLAND                              | M  +  +  +  +  +  +  +                                                    |  7       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2              2  1                                                   |     3 1.6|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   55
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:38.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 3| 3| 3| 3| 3| 3| 3|
                                            | 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 2| 2| 2| 2| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0|                                                      I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0|                                                      S  R   R|
                                            | 4| 4| 4| 4| 4| 4| 4| 4|                                                      U  V   I|
CONTRL F12MTHR07     7                      | 0| 1| 2| 3| 4| 5| 6| 7|                                                      E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1  1  1  1  1                                                   |     7 1.0|
  NEPHROPATHY                               |     2                                                                     |     1 2.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  1  1  1                                                   |     6 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   56
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
GALLBLADDER                                 | +  +  +  +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
INTESTINE LARGE                             | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,COLON                       | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                              3            |          |
INTESTINE SMALL                             | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,ILEUM                       | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE SMALL,JEJUNUM                     | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  APOPTOSIS                                 |                                                                           |          |
  ATROPHY                                   |     1                                                                     |          |
  EOSINOPHILIC FOCUS                        |                                                                         X |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  1           1     1                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1     2  1     1  1     1  1  1  1  1  1  1     1  1  1  1  1  1|          |
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |          |
  LEUKOCYTOSIS                              |           1                                                               |          |
  NECROSIS                                  |        3        1  1  1  1  1     1        1        1  1     1  1     1  1|          |
  TENSION LIPOIDOSIS                        | X                    X     X              X                    X          |          |
  VACUOLIZATION CYTOPLASMIC                 |  3     2  1     1     1           1     1  1  1  1  1  1  2  1  1  2  1  1|          |
MESENTERY                                   |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |     1                                                                     |          |
  ECTASIA,DUCT                              |                                                        3                  |          |
  FOCAL CELLULAR CHANGE                     |     1     3                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1     2     1     1  1  1  1  1  1  1     1  1  1  1|          |
  INFLAMMATION                              |                                                                           |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1     1  1  1  1  2     2  1  1  1     2  1  1  1  1  2  1  1  1|          |
  INFLAMMATION                              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   57
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  MINERALIZATION                            |                                                                           |          |
STOMACH                                     | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,GLANDULAR                           | +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                                                           |          |
TONGUE                                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,MAST CELL           |                          2                    2                           |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |           4                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION,EXTRA ADRENAL TISSUE         |                                                                           |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,SPINDLE CELL                  |  2  1  3  1  2  2  2  2  2  1  3  2     1  3  2  2     2  3  2  3  1  1   |          |
  VACUOLIZATION CYTOPLASMIC                 |                 1                                                         |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                                                                           |          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  M  M  +  +  M  M |          |
PITUITARY GLAND                             | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ANGIECTASIS                               |                                            1                              |          |
  CYST                                      |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                                 3         |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST,FOLLICLE                             |                                         1                                 |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   58
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  INFLAMMATION                              |                                            1                              |          |
  ULTIMOBRANCHIAL CYST                      |              2        2                    2                 2            |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ATROPHY                                   |  3  3  3     2  3  4  4        4  4  3  4  3  4  3  4  3  4  3  3  4  3   |          |
  INFLAMMATION                              |                          2                                                |          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   | X  X     X  X  X  X  X  X  X     X  X  X  X     X  X  X        X     X  X |          |
  CYST                                      |       X                                X  X                       X       |          |
  CYST,PERIOVARIAN TISSUE                   |          X     X  X     X        X           X                       X  X |          |
  HEMATOCYST                                |             X                                                             |          |
  HYPERPLASIA,ADENOMATOUS                   |                                                           3               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |     3     3                                                               |          |
  DILATATION                                |                                            4                              |          |
  FIBROSIS                                  |                    2                                                      |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2  1     3  3  2     2     2     2  2  2  2  2  2  3  2  2  3|          |
  THROMBUS                                  |           2                                                               |          |
VAGINA                                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |     3     3                                                               |          |
  DYSPLASIA                                 |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1         |          |
  INFLAMMATION                              |                                                              2            |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  HYPERPLASIA                               |        2           4                 3                                   3|          |
  HYPOPLASIA                                |     2                                                                     |          |
  PIGMENTATION                              |        3                                                                  |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,PLASMA CELL,MEDIASTINAL       |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   59
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  ATROPHY                                   |        3                                                                  |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                      2                                    |          |
  HEMORRHAGE                                |                                                                 1         |          |
  HYPERPLASIA,LYMPHOID                      |                                                  2     2     2            |          |
  HYPERPLASIA,PLASMA CELL                   |                                                                           |          |
  INFLAMMATION                              |                    2                                                      |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |  3     4                                                                  |          |
  FIBROSIS                                  |                                                              2            |          |
  HEMORRHAGE                                |           4                                                               |          |
  HYPERPLASIA,LYMPHOID                      |                                                                          3|          |
  HYPERPLASIA,PLASMA CELL                   |                                                                           |          |
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |        4                                                                  |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  3     4           3                                                      |          |
  HYPERPLASIA,LYMPHOID                      |                 1     1     2     1              3              3         |          |
  HYPERPLASIA,PLASMA CELL,RED PULP          |                                                                           |          |
THYMUS                                      | +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  + |          |
  ATROPHY,CORTEX                            |  4     4        3     4     2     3     3  3     4  3        2  2  2  3  3|          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                       2                 2                          1  2  2|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  + |          |
  GALACTOCELE                               |                                                                           |          |
  LACTATION                                 |                                                                           |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                    1              3        1           1           1      |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                 1  1  2     2     3     3  2     1  1  4  3  2     3  1  3|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   60
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

SKELETAL MUSCLE                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          2                                                |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1              1  1  2  1  1  1  1     1     1  2        1              1|          |
PERIPHERAL NERVE                            | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1                                       |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                       1   |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |           3                                                               |          |
  HEMORRHAGE                                |           2                                                               |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |              3  2                                                         |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |           2                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1              1  1  1  1  1     1        1     1  1  1     1  2  1  1  2|          |
  INFLAMMATION                              |                 2                       1                    1        1   |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                       2   |          |
HARDERIAN GLAND                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                       2   |          |
  HYPERPLASIA                               |                                                  4                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   61
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:35:52.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 2| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 4| 6| 5| 9| 5| 5| 5| 5| 5| 5| 5| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 4| 0| 2| 2| 8| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 2| 2| 2| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|   S  R   R|
                                            | 6| 6| 7| 8| 2| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 5| 5| 5| 2| 2| 2| 2| 2| 2| 2|   U  V   I|
100MG  F3MTH  08     8                      | 5| 7| 5| 0| 2| 5| 6| 7| 8| 9| 0| 1| 2| 8| 9| 0| 1| 2| 0| 1| 2| 3| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1     1                       1  1  1               |          |
LACRIMAL GLAND                              | +  +  M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  APOPTOSIS                                 |     1                                                                     |          |
  ATROPHY                                   |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1        1        2           1  1     2  1  1        1  1  1   |          |
  NECROSIS                                  |                                                                           |          |
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |     4                                                                     |          |
  CYST,RENAL TUBULE                         |     2           1                          1  1        1                  |          |
  INFARCT                                   |                                                              1            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2     1  1  2  1  1  1  3  1     1  1     1     1  2  1  1  1  1  1  2   |          |
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |          |
  INFLAMMATION,ADVENTITIA                   |                                                                           |          |
URINARY BLADDER                             | +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1              1  1  1  1  1     1     1  1     1  1  1  1  2  2  2  1   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   62
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:01.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  M  +  +  M  +  M  +  M                               | 36       |
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                 1                                                |     2 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  INFLAMMATION                              |                                                                           |     1 3.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE SMALL,ILEUM                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 35       |
  HYPERPLASIA,LYMPHOID                      |  2                       2                                                |     2 2.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,LYMPHOID                      |                 2        2                                                |     2 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  APOPTOSIS                                 |                       4                                                   |     1 4.0|
  ATROPHY                                   |                                                                           |     1 1.0|
  EOSINOPHILIC FOCUS                        |                                                                           |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     3 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1  2        1     2     2  1  1                              |    27 1.1|
  INFILTRATION CELLULAR,PLASMA CELL         |                       3                                                   |     1 3.0|
  LEUKOCYTOSIS                              |                                                                           |     1 1.0|
  NECROSIS                                  |  1  1  1  1  1  1  1        1  1           1                              |    24 1.0|
  TENSION LIPOIDOSIS                        |       X     X           X     X           X                               |    10    |
  VACUOLIZATION CYTOPLASMIC                 |  1  1  1  1  1  1  2     1  1  1        1                                 |    29 1.2|
MESENTERY                                   |                      +                                                    |  1       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     1 2.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     1 1.0|
  ECTASIA,DUCT                              |                                                                           |     1 3.0|
  FOCAL CELLULAR CHANGE                     |                                                                           |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2  1              2     2     1  1                                 |    21 1.1|
  INFLAMMATION                              |                       4                                                   |     1 4.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  3  2  1     2     1  1  2  1  1  1  1                              |    33 1.2|
  INFLAMMATION                              |                       3                                                   |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   63
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  MINERALIZATION                            |                                      2                                    |     1 2.0|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  CYST                                      |     2                                                                     |     1 2.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,MAST CELL           |                                                                           |     2 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |     1 1.0|
  INFLAMMATION                              |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFLAMMATION,EXTRA ADRENAL TISSUE         |                       4                                                   |     1 4.0|
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  HYPERPLASIA,SPINDLE CELL                  |  2  2  2  2  3  2  2  3  2  2  4  1  2  1  2                              |    37 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 1.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CONGESTION                                |                                      2                                    |     1 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                       2                                                   |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
PARATHYROID GLAND                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 31       |
PITUITARY GLAND                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                               | 36       |
  ANGIECTASIS                               |                                                                           |     1 1.0|
  CYST                                      |              2                                                            |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |                    2     4                                                |     3 3.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CYST,FOLLICLE                             |                                                                           |     1 1.0|
  HYPERPLASIA,FOLLICULAR CELL               |     1                                                                     |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1                    2                                    |     2 1.5|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   64
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  INFLAMMATION                              |                                                                           |     1 1.0|
  ULTIMOBRANCHIAL CYST                      |  2     3  2        2              2                                       |     9 2.1|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                               | 37       |
  ATROPHY                                   |  4  3  3  3  3  4  3  3  4  2     3  3  4  4                              |    35 3.3|
  INFLAMMATION                              |                                                                           |     1 2.0|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   | X  X     X  X  X  X  X  X  X  X  X  X  X  X                               |    33    |
  CYST                                      |       X                    X                                              |     6    |
  CYST,PERIOVARIAN TISSUE                   | X              X  X           X                                           |    12    |
  HEMATOCYST                                |                   X                                                       |     2    |
  HYPERPLASIA,ADENOMATOUS                   |                                2        3                                 |     3 2.6|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  3                    3              2                                    |     3 2.6|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     2 3.0|
  DILATATION                                |                                                                           |     1 4.0|
  FIBROSIS                                  |                                                                           |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  3  2  2  3  3  2  3  2  3  2  3  3  3  1  3                              |    32 2.3|
  THROMBUS                                  |                                                                           |     1 2.0|
VAGINA                                      | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  ATROPHY                                   |                                                                           |     2 3.0|
  DYSPLASIA                                 |                 3                                                         |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |     2 1.0|
  INFLAMMATION                              |                 4                                                         |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  HYPERPLASIA                               |                       4              2                                    |     6 3.0|
  HYPOPLASIA                                |                                                                           |     1 2.0|
  PIGMENTATION                              |                                                                           |     1 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  HYPERPLASIA,PLASMA CELL,MEDIASTINAL       |                       4                                                   |     1 4.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   65
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  ATROPHY                                   |                                                                           |     1 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     1 2.0|
  HEMORRHAGE                                |                                                                           |     1 1.0|
  HYPERPLASIA,LYMPHOID                      |  2           3                                                            |     5 2.2|
  HYPERPLASIA,PLASMA CELL                   |                       4                                                   |     1 4.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     2 3.5|
  FIBROSIS                                  |                                                                           |     1 2.0|
  HEMORRHAGE                                |                                                                           |     1 4.0|
  HYPERPLASIA,LYMPHOID                      |     2                                                                     |     2 2.5|
  HYPERPLASIA,PLASMA CELL                   |                       4                                                   |     1 4.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                       3                                                   |     2 3.5|
  HEMATOPOIETIC CELL PROLIFERATION          |                       4                                                   |     4 3.5|
  HYPERPLASIA,LYMPHOID                      |     1        3                 3     3                                    |    10 2.1|
  HYPERPLASIA,PLASMA CELL,RED PULP          |                       4                                                   |     1 4.0|
THYMUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +                               | 33       |
  ATROPHY,CORTEX                            |  3  2     3  2        4  2  3  3  2                                       |    24 2.8|
  HYPERPLASIA,LYMPHOID,MEDULLA              |        3     2     2     2     2  2  3     2                              |    13 2.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +                               | 36       |
  GALACTOCELE                               |                             2                                             |     1 2.0|
  LACTATION                                 |                                   2                                       |     1 2.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 2                                                         |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  FIBROUS OSTEODYSTROPHY                    |  2                       1  1     1                                       |     9 1.3|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  2  1     2  3  1  2  2  2  4  3  1  2  4                                 |    28 2.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   66
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1                                                            |     2 1.5|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                          1                                       |     2 1.0|
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     1     1  1  1     1           1  1  1                                 |    21 1.0|
PERIPHERAL NERVE                            | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CONGESTION                                |                                                                           |     1 3.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |     2 2.5|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  2  1  2  1  1     1  1  1  2  1                              |    30 1.1|
  INFLAMMATION                              |                                                                           |     4 1.2|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  INFLAMMATION                              |                                                                           |     1 2.0|
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M                               | 38       |
  ATROPHY                                   |                                                                           |     1 2.0|
  HYPERPLASIA                               |        4                                                                  |     2 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   67
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:02.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4|                                 U  V   I|
100MG  F3MTH  08     8                      | 3| 4| 5| 6| 7| 8| 9| 2| 3| 4| 5| 6| 7| 8| 9|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1     1  1     1     1        1                                 |    13 1.0|
LACRIMAL GLAND                              | +  +  +  M  +  +  +  +  +  +  +  +  +  M  +                               | 33       |
  APOPTOSIS                                 |                                                                           |     1 1.0|
  ATROPHY                                   |     2                                                                     |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2     1     1  3  1        1  1     1                              |    21 1.2|
  NECROSIS                                  |                       2                                                   |     1 2.0|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                               | 38       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |     1 4.0|
  CYST,RENAL TUBULE                         |  1  1                       1           1                                 |     9 1.1|
  INFARCT                                   |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2  1     1     2     1  1  2  1  1  1  1                              |    31 1.2|
  INFILTRATION CELLULAR,PLASMA CELL         |                       2                                                   |     1 2.0|
  INFLAMMATION,ADVENTITIA                   |                       2                                                   |     1 2.0|
URINARY BLADDER                             | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2     2  2  2  1  1  2  1  1  1  2  1                              |    31 1.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   68
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:15.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DILATATION                                |           2                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
GALLBLADDER                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1                                                         |          |
  INFLAMMATION                              |                                                                           |          |
INTESTINE LARGE                             | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                         2                                 |          |
INTESTINE LARGE,COLON                       | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL                             | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE SMALL,ILEUM                       | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                   3                                       |          |
INTESTINE SMALL,JEJUNUM                     | +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,GOBLET CELL                   |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                                                                       2   |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                      X    |          |
  DEGENERATION,CENTRILOBULAR                |                       2                                                   |          |
  EOSINOPHILIC FOCUS                        |                                  X                    X                   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  2     2  2                                1                    2         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                 1     1  1  2  3  1  1  1  1  1  1  2  2  1  1  1  2|          |
  NECROSIS                                  |                             1  1  1  1  1  1     1     1  1  1  1  2  1  1|          |
  NECROSIS,COAGULATIVE                      |     2  2           2                                                      |          |
  TENSION LIPOIDOSIS                        |                                  X              X  X     X        X       |          |
  VACUOLIZATION CYTOPLASMIC                 |  2           1  1           1     2  1     1        1  1  2  1  1  1  1  1|          |
MESENTERY                                   |                   +                                                       |          |
  NECROSIS,FAT                              |                                                                           |          |
PANCREAS                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                    4      |          |
  FOCAL CELLULAR CHANGE                     |                                               1              1            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     2              1           1  1     1     1           1     2  2  1|          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   69
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |           3                                                               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2           1  2  2     2  1  2  2  1  1  1     2  2  2  1  1  1  1  2|          |
STOMACH                                     | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |                                                                           |          |
STOMACH,GLANDULAR                           | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                2                                          |          |
  INFLAMMATION                              |                                                                           |          |
TONGUE                                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CARDIOMYOPATHY                            |     2                                                                     |          |
  INFLAMMATION                              |           2                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  A  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | +  A  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,FATTY                        |                                                     2                     |          |
  ECTOPIC TISSUE                            |                                     X                                     |          |
  FOCAL CELLULAR CHANGE                     |                                         3                                 |          |
  HYPERPLASIA,SPINDLE CELL                  |  2     2  1  1  2  2        2  2  2     2  1  3  2  4  1  3  2  2  1  2  2|          |
ADRENAL GLAND,MEDULLA                       | +  A  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYTOPLASMIC ALTERATION                    |                                                                           |          |
ISLETS, PANCREATIC                          | +  A  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M |          |
  ECTOPIC THYMUS                            |                                                                   X       |          |
PITUITARY GLAND                             | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                                           |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |                                                                           |          |
  GOITER ADENOMATOUS                        |                       2                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   70
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             2                                             |          |
  ULTIMOBRANCHIAL CYST                      |                       2     2              2     2        2     2         |          |
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |                      +                                                    |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  + |          |
  ATROPHY                                   |     2        4  3           3  4  4     4  4  4  3  2     3  3     3  3  3|          |
  INFLAMMATION                              |                 2                                   1                     |          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   | X  X  X  X     X  X  X     X  X  X  X  X  X  X  X  X  X     X  X  X  X  X |          |
  CYST                                      | X                                   X        X        X                   |          |
  CYST,PERIOVARIAN TISSUE                   |                            X  X           X              X                |          |
  HEMATOCYST                                |                   X                    X           X                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  OVOTESTIS                                 |                                                                           |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           3           3                                                   |          |
  DILATATION                                |  4                    2                                                   |          |
  FIBROSIS                                  |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2  2           4  2     4  2  2  1  3  2  3     2     1  1   |          |
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |  3        3                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEPLETION                                 |                             2                                             |          |
  HYPERPLASIA                               |     3     4                                                     4         |          |
  PIGMENTATION                              |                                                     2                     |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,PLASMA CELL                   |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   71
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  INFLAMMATION                              |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                           |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |  3        2           2     2           4     3        2              2   |          |
LYMPH NODE,MESENTERIC                       | +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  HEMORRHAGE                                |                                                                    2      |          |
  HYPERPLASIA,LYMPHOID                      |                             3                                   2         |          |
  HYPERPLASIA,PLASMA CELL                   |                                                                           |          |
  HYPERPLASIA,RETICULUM CELL                |                                                                    2      |          |
  INFLAMMATION                              |  3                                                                        |          |
SPLEEN                                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION                        |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  4     3  3        3                 3                          3        3|          |
  HYPERPLASIA,LYMPHOID                      |                 1           2                 3     2  2  2        3     1|          |
THYMUS                                      | +  M  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  + |          |
  ATROPHY,CORTEX                            |  3              4              4  4  3  3  3  2     2  2     3  2  3      |          |
  CYST                                      |                                                                           |          |
  ECTOPIC PARATHYROID GLAND                 |                                                                X          |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                             3              2           2           3     1|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |  2                                                                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
  LACTATION                                 |                                                  2                        |          |
  METAPLASIA,SQUAMOUS                       |    X                                                                      |          |
SKIN                                        | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   72
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY                    |                             2                          2                  |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                             3  2  1  1  2  3  3     1  2  3  1     2      |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                       1  1     1  1  1  1     1  1  1     2  1        1  1|          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  +  M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMORRHAGE                                |                                                           3               |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                               2                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                1                                          |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1     2  1     1  1  1  2  1           1  2  2  1  2  1  1  2|          |
  INFLAMMATION                              |           4                                                               |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DILATATION,GLANDS                         |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2                              |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  A  A  A  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             1                 1     1        1     1  1  1|          |
LACRIMAL GLAND                              | +  +  +  M  +  +  +  +  M  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   73
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:16.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 0| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 9| 7| 7| 2| 8| 8| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 0| 5| 4| 6| 0| 4| 2| 1| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 7| 9| 9| 6| 7| 8| 1| 2| 9| 0| 1| 1| 1| 1| 1| 4| 4| 4| 4| 4| 4| 4| 1| 1| 1|   U  V   I|
100MG  F6MTH  09     9                      | 7| 2| 4| 4| 0| 8| 3| 1| 0| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 5| 6| 7|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2                          2  1        1     1           2           1   |          |
ZYMBAL'S GLAND                              | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                     4                     |          |
  CYST,RENAL TUBULE                         |              1                 1  1     1  1  1           1  1            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  1  1  1     1  1  1  1     1  2  1  2  1     1  1  1  1  1|          |
  NECROSIS,COAGULATIVE                      |        1                                                                  |          |
  NEPHROPATHY                               |                                                     1                     |          |
URINARY BLADDER                             | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1           1  2  1     2  1  1  2     1  1     2  1  1  1  1  2  1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   74
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:24.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DILATATION                                |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                                                   |     1 1.0|
GALLBLADDER                                 | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +                               | 36       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2  1                                                |     4 1.2|
  INFLAMMATION                              |     1                                                                     |     1 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,LYMPHOID                      |                                   2                                       |     2 2.0|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,LYMPHOID                      |           2                                                               |     1 2.0|
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,LYMPHOID                      |           2     2                                                         |     3 2.3|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  HYPERPLASIA,GOBLET CELL                   |                       2                                                   |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |                          2                                                |     2 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  BASOPHILIC FOCUS                          | X                                      X                                  |     3    |
  DEGENERATION,CENTRILOBULAR                |                                                                           |     1 2.0|
  EOSINOPHILIC FOCUS                        |                                                                           |     2    |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     5 1.8|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1     1  1  1  1     1  1     1  1                              |    29 1.2|
  NECROSIS                                  |     1        1  1                 1  1  1  1                              |    21 1.0|
  NECROSIS,COAGULATIVE                      |                                                                           |     3 2.0|
  TENSION LIPOIDOSIS                        |    X        X        X     X        X                                     |    10    |
  VACUOLIZATION CYTOPLASMIC                 |     1  1  1  1  1  1  1  1     1  1  1  1  1                              |    28 1.1|
MESENTERY                                   |    +                                                                      |  2       |
  NECROSIS,FAT                              |     4                                                                     |     1 4.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                                                                           |     1 4.0|
  FOCAL CELLULAR CHANGE                     |                                                                           |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1                    1  1        1                                 |    16 1.1|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   75
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |              4           2                                                |     3 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2  1  1  1  2  2  1  1  1  1  2  1  1                              |    35 1.4|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  HYPERKERATOSIS                            |                       2                                                   |     1 2.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  CYST                                      |           1                 1                                             |     3 1.3|
  INFLAMMATION                              |           1                                                               |     1 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +  +  +  +  +  +  +  +  +  +  M  +  +                               | 35       |
BLOOD VESSEL,AORTA                          | M  M  +  +  +  +  +  +  +  +  +  +  M  +  +                               | 35       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CARDIOMYOPATHY                            |                                                                           |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  DEGENERATION,FATTY                        |                                                                           |     1 2.0|
  ECTOPIC TISSUE                            |                                                                           |     1    |
  FOCAL CELLULAR CHANGE                     |              2                                                            |     2 2.5|
  HYPERPLASIA,SPINDLE CELL                  |  1  1  2  2  2  2  2  3  1  3  1  1  2                                    |    34 1.8|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  CYTOPLASMIC ALTERATION                    |              2                                                            |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
PARATHYROID GLAND                           | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +                               | 33       |
  ECTOPIC THYMUS                            |                                                                           |     1    |
PITUITARY GLAND                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                               | 36       |
  HYPERPLASIA,PARS DISTALIS                 |     2                                                                     |     1 2.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DEGENERATION                              |                                         2                                 |     1 2.0|
  GOITER ADENOMATOUS                        |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   76
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  HYPERPLASIA,FOLLICULAR CELL               |                    2                                                      |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |     2 1.5|
  ULTIMOBRANCHIAL CYST                      |                 2                    2                                    |     8 2.0|
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +                               | 33       |
  ATROPHY                                   |  3  3  3  4  3  3  3     3  3  3  4     3  4                              |    29 3.2|
  INFLAMMATION                              |                                                                           |     2 1.5|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                               | 39       |
  ATROPHY                                   | X  X  X  X  X  X  X  X           X  X  X  X                               |    34    |
  CYST                                      |       X                                X                                  |     6    |
  CYST,PERIOVARIAN TISSUE                   |          X                       X                                        |     6    |
  HEMATOCYST                                |             X           X                                                 |     5    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     1 2.0|
  OVOTESTIS                                 |                                            1                              |     1 1.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     2 3.0|
  DILATATION                                |                          4                                                |     3 3.3|
  FIBROSIS                                  |     2                                                                     |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2  2  3  2  3     2  4     2  4  2  1  2                                 |    26 2.3|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  ATROPHY                                   |                                                                           |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DEPLETION                                 |                                                                           |     1 2.0|
  HYPERPLASIA                               |              2                                                            |     4 3.2|
  PIGMENTATION                              |                                                                           |     1 2.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  HYPERPLASIA,PLASMA CELL                   |     4                                                                     |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   77
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  INFLAMMATION                              |     2                                                                     |     1 2.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |              3                                                            |     1 3.0|
  HEMORRHAGE                                |                    2                                                      |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |           2              2                                                |    10 2.4|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  ANGIECTASIS                               |                                            4                              |     1 4.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |                    2                 2                                    |     4 2.2|
  HYPERPLASIA,PLASMA CELL                   |                       4                                                   |     1 4.0|
  HYPERPLASIA,RETICULUM CELL                |                                                                           |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 3.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  AMYLOID DEPOSITION                        |                                2                                          |     1 2.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     7 3.1|
  HYPERPLASIA,LYMPHOID                      |                          3              1  1                              |    11 1.9|
THYMUS                                      | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 31       |
  ATROPHY,CORTEX                            |     2  3              4  2     3        3  2                              |    20 2.8|
  CYST                                      |                 2                                                         |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |     2           2        2  3  2        3  2                              |    12 2.2|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                               | 38       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  LACTATION                                 |                                                                           |     1 2.0|
  METAPLASIA,SQUAMOUS                       |                                                                           |     1    |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   78
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY                    |                       1  1              1                                 |     5 1.4|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  1     2  1  2  2  1  4  1  3  2  2  2  2                                 |    25 1.9|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     1  1  1  1  1     1     1  1  1     1                                 |    23 1.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFLAMMATION                              |  1                                                                        |     1 1.0|
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +                               | 34       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  HEMORRHAGE                                |                                                                           |     1 3.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |  1                                                                        |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1     1  1  2  1  2  1  1  2  1  1                              |    29 1.3|
  INFLAMMATION                              |           1                                                               |     2 2.5|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DILATATION,GLANDS                         |                 3                                                         |     1 3.0|
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 34       |
HARDERIAN GLAND                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +                               | 38       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1  1     1        1  1  1  1  1                              |    16 1.0|
LACRIMAL GLAND                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +                               | 33       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   79
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:25.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9|                                 S  R   R|
                                            | 1| 1| 9| 9| 9| 9| 9| 3| 3| 3| 3| 3| 3| 4| 4|                                 U  V   I|
100MG  F6MTH  09     9                      | 8| 9| 1| 2| 3| 4| 5| 4| 5| 6| 7| 8| 9| 0| 1|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2  1  1        2  1  1     1        1                              |    17 1.2|
ZYMBAL'S GLAND                              | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |     1 4.0|
  CYST,RENAL TUBULE                         |        1                                                                  |     9 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1           1     1  2  1  1  2  1                              |    31 1.1|
  NECROSIS,COAGULATIVE                      |                                                                           |     1 1.0|
  NEPHROPATHY                               |                       1                                                   |     2 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1     1  2  1  1  1  1  1  2  1                              |    33 1.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   80
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:39.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
GALLBLADDER                                 | +  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            1     1     1              1   |          |
INTESTINE LARGE                             | A  +  A  +  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | A  A  A  A  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,COLON                       | A  +  A  +  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,GOBLET CELL                   |           3                                                               |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,RECTUM                      | A  +  A  M  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
INTESTINE SMALL                             | A  A  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | A  A  A  A  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
INTESTINE SMALL,ILEUM                       | A  A  A  A  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  HYPERPLASIA,LYMPHOID                      |                                            4                              |          |
INTESTINE SMALL,JEJUNUM                     | A  A  A  A  A  A  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  CLEAR CELL FOCUS                          |                X                                                          |          |
  DEGENERATION,CYSTIC                       |                                                                       3   |          |
  DEGENERATION,FATTY                        |                                                                           |          |
  EOSINOPHILIC FOCUS                        |                                                          X  X           X |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                 2                                                         |          |
  HYPERPLASIA,KUPFFER CELL                  |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1        1  1  2  1  1        1  1  1  1     1  1     1     2|          |
  MIXED CELL FOCUS                          |                                                                           |          |
  NECROSIS                                  |                       1  1  1  1  1  1  1        1  1  1        1  1  1   |          |
  NECROSIS,COAGULATIVE                      |                                                                           |          |
  TENSION LIPOIDOSIS                        |                                        X  X     X                         |          |
  VACUOLIZATION CYTOPLASMIC                 |  1        1  1        1  1  1              1  1  1  1  1  1  1  1  1      |          |
PANCREAS                                    | +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FOCAL CELLULAR CHANGE                     |                                               1                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                             1     1  1  1  1           1  1  1  1  1|          |
SALIVARY GLANDS                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                             2           2                                 |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1           1  1  2  1  2  1  1  1  1  1  1  1  1     1  1     1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   81
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  MINERALIZATION                            |                                                                           |          |
STOMACH                                     | +  +  A  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | A  +  A  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |                                                                       2   |          |
  HYPERPLASIA                               |                                                                           |          |
  ULCER                                     |                             3                                             |          |
STOMACH,GLANDULAR                           | +  +  A  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                      1  1                                 |          |
  HYPERPLASIA                               |                                                     1                     |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                 3                                                         |          |
  DILATATION                                |                 4                                                         |          |
  HEMORRHAGE,VALVE                          |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  A  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | +  +  A  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                 3                                                         |          |
  DEGENERATION,FATTY                        |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |  2              2     1  2  2  2  2  2  2  2  3  2  2  2     1     1  2  2|          |
  VACUOLIZATION CYTOPLASMIC                 |                                                           2               |          |
ADRENAL GLAND,MEDULLA                       | +  +  A  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                 3                                                         |          |
ISLETS, PANCREATIC                          | +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                          1                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
PARATHYROID GLAND                           | +  +  A  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ECTOPIC THYMUS                            |                                                                           |          |
PITUITARY GLAND                             | +  +  A  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   82
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  CYST                                      |     2                                                                     |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                        2                  |          |
THYROID GLAND                               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST,FOLLICLE                             |                             2                                             |          |
  DEGENERATION                              |                                                                           |          |
  ECTOPIC THYMUS                            |                                                          X                |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |          |
  HYPERTROPHY,FOLLICULAR CELL               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1                                       |          |
  ULTIMOBRANCHIAL CYST                      |                          2                                   2     2  2   |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  A  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  + |          |
  ATROPHY                                   |  2  4     3  3  3     3  3  3  3  3     4  3  3     3  3  3     3  3     3|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             1                                             |          |
OVARY                                       | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |    X     X  X  X     X  X     X  X  X  X        X  X  X  X  X  X  X  X  X |          |
  CYST                                      |                                           X              X     X          |          |
  CYST,PERIOVARIAN TISSUE                   |                      X  X  X                 X     X  X                   |          |
  HEMATOCYST                                |                                                             X             |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             1                                             |          |
  MINERALIZATION                            |                                                                           |          |
UTERUS                                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |              3                                                            |          |
  DILATATION                                |                                                                           |          |
  ECTASIA,VEIN                              |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |                       2  4     1  3  2  3  3  2  3  4  3  2  3  2  2  4  3|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |              2                                                            |          |
VAGINA                                      | +  A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  METAPLASIA                                |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   83
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |  3              3                                               3         |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                            2                              |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                           |          |
  CONGESTION,SINUS                          |                                                                           |          |
  HEMORRHAGE                                |                                2                                          |          |
  HYPERPLASIA,LYMPHOID                      |                             2           3                                 |          |
SPLEEN                                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                 2                                                         |          |
  CONGESTION                                |                                                                       1  2|          |
  ERYTHROPHAGOCYTOSIS                       |                                   1                                       |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  4              4                                                         |          |
  HYPERPLASIA,LYMPHOID                      |                          1  2     1  3  1           2           2     1   |          |
THYMUS                                      | +  +  A  M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M |          |
  ATROPHY,CORTEX                            |  3           3        4  3  2  2  3  2  3  4  4  3  2     4     3  3      |          |
  CONGESTION                                |                                                                 2         |          |
  ECTOPIC PARATHYROID GLAND                 |                                  X                                        |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                            2                    2         |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  A  +  M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                                          2|          |
SKIN                                        | +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ALOPECIA                                  |                 4                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,CARTILAGE                    |                                                                           |          |
  FIBROUS OSTEODYSTROPHY                    |                       3  2                                3  1           1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   84
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                    3  3  4  1  1  1  1  3  2  2  2  1  3  3  2        3  2|          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                     1                     |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                    1     1  1  1  1     1     1        1  1  1  1  1  1  1|          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  M  A  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONCRETION                                |                                                                           |          |
  CRYSTALS                                  |                                                                           |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |           4                                                               |          |
  GIANT CELL                                |                                                                           |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                      1                 1                  |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                     2                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1              1  1  1  1  1  1  1  1     1     1     1  1     1|          |
  INFLAMMATION                              |                                                                           |          |
  THROMBUS,CAPILLARY                        |                 4                                                         |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
TRACHEA                                     | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                             2                                             |          |
  FOREIGN BODY                              |                                                                         X |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   85
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:40.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 9| 9| 1| 1| 3| 6| 9| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 3| 1| 6| 9| 9| 8| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 1| 1| 2| 3| 3| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7|   S  R   R|
                                            | 5| 9| 0| 0| 7| 1| 1| 0| 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 4| 0| 1| 1|   U  V   I|
100MG  F12MTH 10    10                      | 8| 8| 2| 5| 6| 4| 6| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 9| 0| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | A  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HARDERIAN GLAND                             | +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                 1                 1        1      |          |
  INFLAMMATION                              |                                                                           |          |
LACRIMAL GLAND                              | +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ATROPHY                                   |                       2                                                   |          |
  CYTOMEGALY                                |                                                                           |          |
  ECTASIA,DUCT                              |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1     1                          1  1  1  1  1           1      |          |
ZYMBAL'S GLAND                              | +  +  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                 3                                                         |          |
  CYST,RENAL TUBULE                         |                                1              1  1     1        1     1   |          |
  GLOMERULOSCLEROSIS                        |                 3                                                         |          |
  HYDRONEPHROSIS                            |                                                        1                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  2     1  2  1  1  1  1  1  1  1  1  1  1  1     1  3  2  1|          |
  NEPHROPATHY                               |                                                                       1   |          |
  PIGMENTATION,RENAL TUBULE                 |                                                                       1   |          |
URINARY BLADDER                             | +  +  A  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2        1           1  1  2  1  1  1  1     1  1  1  1  1     1  1      |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   86
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +                               | 36       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1        2                                                      |     6 1.1|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 34       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 32       |
  HYPERPLASIA,LYMPHOID                      |                    2     2        2     2                                 |     4 2.0|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 34       |
  HYPERPLASIA,GOBLET CELL                   |                                                                           |     1 3.0|
  HYPERPLASIA,LYMPHOID                      |                                      2                                    |     1 2.0|
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 32       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 33       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 33       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          2                                                |     1 2.0|
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 31       |
  HYPERPLASIA,LYMPHOID                      |                                         2                                 |     2 3.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 32       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  BASOPHILIC FOCUS                          |                   X                       X                               |     2    |
  CLEAR CELL FOCUS                          |                                           X                               |     2    |
  DEGENERATION,CYSTIC                       |                                                                           |     1 3.0|
  DEGENERATION,FATTY                        |                                            2                              |     1 2.0|
  EOSINOPHILIC FOCUS                        |                                                                           |     3    |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     1 2.0|
  HYPERPLASIA,KUPFFER CELL                  |                                         3                                 |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1     1  1  1  1  2     1  1     1  1                              |    27 1.1|
  MIXED CELL FOCUS                          |                         X                                                 |     1    |
  NECROSIS                                  |  1  1           1  1        1  1  1                                       |    20 1.0|
  NECROSIS,COAGULATIVE                      |                                            2                              |     1 2.0|
  TENSION LIPOIDOSIS                        |          X  X  X        X  X                                              |     8    |
  VACUOLIZATION CYTOPLASMIC                 |  1                 1  1     1  1  1  1  2  1                              |    24 1.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  FOCAL CELLULAR CHANGE                     |  1                                                                        |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1        1                 1     2                              |    16 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                          1                                                |     3 1.6|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1  1  1  1     2  1  2  1  1  1  1     2                              |    31 1.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   87
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  MINERALIZATION                            |                                         1                                 |     1 1.0|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 35       |
  HYPERKERATOSIS                            |                          2                                                |     2 2.0|
  HYPERPLASIA                               |     2                                                                     |     1 2.0|
  ULCER                                     |                                                                           |     1 3.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
  CYST                                      |                                                                           |     2 1.0|
  HYPERPLASIA                               |                                                                           |     1 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +                               | 37       |
BLOOD VESSEL,AORTA                          | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +                               | 37       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  CONGESTION                                |                                                                           |     1 3.0|
  DILATATION                                |                                                                           |     1 4.0|
  HEMORRHAGE,VALVE                          |    X                                                                      |     1    |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  CONGESTION                                |                                                                           |     1 3.0|
  DEGENERATION,FATTY                        |                                         4                                 |     1 4.0|
  HYPERPLASIA,SPINDLE CELL                  |  2  2  2  2  2  3  2  1  2  1  2  3  1     3                              |    32 1.9|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 2.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  CONGESTION                                |                                                                           |     1 3.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  HYPERPLASIA                               |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |     1 1.0|
PARATHYROID GLAND                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +                               | 36       |
  ECTOPIC THYMUS                            | X                                                                         |     1    |
PITUITARY GLAND                             | +  +  +  +  +  +  +  M  +  +  +  +  M  +  M                               | 33       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   88
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  CYST                                      |                                                                           |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |                                                                           |     1 2.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  CYST,FOLLICLE                             |     2                       1                                             |     3 1.6|
  DEGENERATION                              |                       1                                                   |     1 1.0|
  ECTOPIC THYMUS                            |                                                                           |     1    |
  HYPERPLASIA,FOLLICULAR CELL               |                                         2                                 |     1 2.0|
  HYPERTROPHY,FOLLICULAR CELL               |                                         2                                 |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2                              |     2 1.5|
  ULTIMOBRANCHIAL CYST                      |              2     2                       3                              |     7 2.1|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M                               | 33       |
  ATROPHY                                   |  3     3  3  3     3  3  4  3  3  3  4  3                                 |    31 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  ANGIECTASIS                               |        2                                                                  |     1 2.0|
  ATROPHY                                   | X        X  X  X  X  X  X  X  X  X  X  X  X                               |    32    |
  CYST                                      |    X     X  X           X        X  X                                     |     9    |
  CYST,PERIOVARIAN TISSUE                   |          X     X                                                          |     8    |
  HEMATOCYST                                |             X  X                          X                               |     4    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  MINERALIZATION                            |           2                                                               |     1 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                                                                           |     1 3.0|
  DILATATION                                |                                      3                                    |     1 3.0|
  ECTASIA,VEIN                              |                                            2                              |     1 2.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  3  2     2  2  3  2  3     2  2  2     2  2                              |    29 2.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2                              |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 37       |
  METAPLASIA                                |        4                                                                  |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   89
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  HYPERPLASIA                               |                                                                           |     3 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  HYPERPLASIA,LYMPHOID                      |              2           2     3                                          |     4 2.2|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                          2                                                |     1 2.0|
  CONGESTION,SINUS                          |              2                                                            |     1 2.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |     2                                2                                    |     4 2.2|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  ATROPHY                                   |                                                                           |     1 2.0|
  CONGESTION                                |  2                                                                        |     3 1.6|
  ERYTHROPHAGOCYTOSIS                       |                                                                           |     1 1.0|
  HEMATOPOIETIC CELL PROLIFERATION          |           3                          3                                    |     4 3.5|
  HYPERPLASIA,LYMPHOID                      |  1     1                 2           3                                    |    12 1.6|
THYMUS                                      | +  M  +  +  +  +  +  M  M  +  +  +  M  +  +                               | 30       |
  ATROPHY,CORTEX                            |        4  3  3  3           2  1  3     3  3                              |    25 2.9|
  CONGESTION                                |                                                                           |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                 2  3        1              3                              |     6 2.1|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                               | 36       |
  HYPERPLASIA                               |     2  3                                                                  |     3 2.3|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  ALOPECIA                                  |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  DEGENERATION,CARTILAGE                    |                                            4                              |     1 4.0|
  FIBROUS OSTEODYSTROPHY                    |  1                       1        2     2                                 |     9 1.7|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   90
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  2  1     2     3  1  2  3     1  2  2  3  2                              |    29 2.1|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     2     1  1  1  1  1     1  1     1  1                                 |    24 1.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +                               | 34       |
  CONCRETION                                |     2                                                                     |     1 2.0|
  CRYSTALS                                  |                          1                                                |     1 1.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
  CONGESTION                                |                                                                           |     1 4.0|
  GIANT CELL                                |                          2                                                |     1 2.0|
  HEMORRHAGE                                |                    2     2                                                |     2 2.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |     2 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                    1                                                      |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1     1  1     2  1  1  2  2  2  2                              |    27 1.1|
  INFLAMMATION                              |                             1  1        1                                 |     3 1.0|
  THROMBUS,CAPILLARY                        |                                                                           |     1 4.0|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 40       |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 39       |
  CYST                                      |                                                                           |     1 2.0|
  FOREIGN BODY                              |                                                                           |     1    |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   91
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:36:49.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                 S  E   V|
FEMALE                      CARCASS ID      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|                                 S  R   R|
                                            | 1| 1| 1| 8| 8| 8| 8| 8| 9| 4| 4| 4| 5| 5| 5|                                 U  V   I|
100MG  F12MTH 10    10                      | 2| 3| 4| 5| 6| 7| 8| 9| 0| 7| 8| 9| 0| 1| 2|                                 E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 35       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1           1           1                                                |     8 1.0|
  INFLAMMATION                              |                    4                                                      |     1 4.0|
LACRIMAL GLAND                              | M  M  +  +  +  +  M  +  +  M  +  +  +  +  +                               | 32       |
  ATROPHY                                   |                                         2                                 |     2 2.0|
  CYTOMEGALY                                |                                         2                                 |     1 2.0|
  ECTASIA,DUCT                              |                          2                                                |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1        3        1        2                              |    13 1.2|
ZYMBAL'S GLAND                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 38       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                      2                                    |     2 2.5|
  CYST,RENAL TUBULE                         |           1                                3                              |     8 1.2|
  GLOMERULOSCLEROSIS                        |                                                                           |     1 3.0|
  HYDRONEPHROSIS                            |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1     1  1  1     1        1  1  2                              |    32 1.1|
  NEPHROPATHY                               |                    1     2  1                                             |     4 1.2|
  PIGMENTATION,RENAL TUBULE                 |                                                                           |     1 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                               | 36       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1  1  1  1  1  2  2     1  1  1                                 |    28 1.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   92
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:04.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
GALLBLADDER                                 | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1                                         1      |          |
INTESTINE LARGE                             | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |          |
INTESTINE LARGE,COLON                       | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,GOBLET CELL                   |              3                                                            |          |
INTESTINE LARGE,RECTUM                      | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROSIS                                  |              3                                                            |          |
INTESTINE SMALL                             | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,ILEUM                       | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
  ATROPHY                                   |              2                                                            |          |
INTESTINE SMALL,JEJUNUM                     | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                 2                       1           1  1                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1     1  1  2  1  1  1  2  1  2  1  3  2  1  1  1  1  1     1  1  1  1|          |
  INFLAMMATION                              |                                            1                              |          |
  NECROSIS                                  |              1     1           1  1              1        1        1     1|          |
  NECROSIS,COAGULATIVE                      |                                                                 1         |          |
  TENSION LIPOIDOSIS                        |                   X  X                             X     X  X  X     X  X |          |
  VACUOLIZATION CYTOPLASMIC                 |  1  1        1                 1           1              1     1  1  2  1|          |
MESENTERY                                   |                                                          +                |          |
  NECROSIS,FAT                              |                                                           4               |          |
PANCREAS                                    | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           1                                                              1|          |
  DEGENERATION                              |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                 1           1  1  1  1  1              1  1     1  1  1|          |
  INFLAMMATION                              |                 2                                                         |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2     1        1     2  1  1  2  2  1  1  2     2  1  2  1  2  2  2  1|          |
STOMACH                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   93
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:04.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  HYPERKERATOSIS                            |                                                                           |          |
STOMACH,GLANDULAR                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                          2                    1                           |          |
  HYPERPLASIA                               |                          2                                                |          |
  MINERALIZATION                            |                          1                                                |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,MAST CELL           |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CARDIOMYOPATHY                            |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1         |          |
  THROMBUS                                  |        2                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                                           |          |
ADRENAL GLAND,CORTEX                        | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |  2     1  3  2  2  3  3  3  2  2  3  2  2  2  2  2  2  2  1  2  1  2     2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  VACUOLIZATION CYTOPLASMIC                 |                    2                                                      |          |
ADRENAL GLAND,MEDULLA                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |  3                                                                        |          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ISLETS, PANCREATIC                          | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  M |          |
  CYST                                      |                                   2                                       |          |
  ECTOPIC THYMUS                            |                                  X  X                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          3                                                |          |
PITUITARY GLAND                             | M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  + |          |
  CYTOMEGALY                                |                                2                                          |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   94
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:05.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                      2  2                                 |          |
  HYPERTROPHY,PARS DISTALIS                 |           1                                            2                  |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST,FOLLICLE                             |                                                                           |          |
  ECTOPIC THYMUS                            |                                                                      X    |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             1                                             |          |
  INFLAMMATION                              |                                                                           |          |
  ULTIMOBRANCHIAL CYST                      |  3                       3  2     2     2           2     2     2         |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  M  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  M  + |          |
  ATROPHY                                   |  4     3        3  4  3  2  3  3     3     3  4  3  4  4  3  4  4        4|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      2                                    |          |
  INFLAMMATION                              |                                                                           |          |
OVARY                                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |       X     X  X  X  X  X  X  X  X  X  X     X  X  X  X        X  X  X  X |          |
  CONGESTION                                |                                            2                              |          |
  CYST                                      | X              X                       X                 X  X  X          |          |
  CYST,PERIOVARIAN TISSUE                   | X                    X  X     X     X                             X       |          |
  HEMATOCYST                                |          X                                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          2                                                |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                              2            |          |
  ATROPHY                                   |        3                          4                                       |          |
  DILATATION                                |                                   4        4                              |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2        2     2  2  4  3  2  2     2  1  2     1  2     2  3  2  2  2  2|          |
  INFLAMMATION                              |                                                                    2      |          |
VAGINA                                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                   4                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   95
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:05.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |              3                                2                           |          |
  MYELOFIBROSIS                             |                                                              4            |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID,BRONCHIAL            |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HEMORRHAGE                                |                    2                                                      |          |
  HYPERPLASIA,LYMPHOID                      |                       2           3        2              3           1   |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                     3                     |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HEMORRHAGE                                |                                                                       2   |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
  HYPERPLASIA,RETICULUM CELL                |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
SPLEEN                                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |           3                                                               |          |
  CONGESTION                                |                                         2                                 |          |
  HEMATOPOIETIC CELL PROLIFERATION          |           3  3                                                            |          |
  HYPERPLASIA,LYMPHOID                      |                    1  2  1        2  3  4           3                    1|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
THYMUS                                      | M  +  M  +  M  M  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,CORTEX                            |           4        3        3  3  3  2  3  3        3  2  4        4  3  2|          |
  CYST                                      |                                                                           |          |
  ECTOPIC PARATHYROID GLAND                 |                                                                   X       |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                2  4     2           3  2  1              3|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                 2                                                         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                    1      |          |
  LACTATION                                 |                                                                           |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   96
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:05.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                    1  1  1           3              1  1           2      |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                    2  3  1  1  3  2  3  3  1  1     3  2  1  2  2  2  2   |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                     2                     |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,THALAMUS                   |                                                                           |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEVELOPMENTAL MALFORMATION                |                                                          X                |          |
  GLIOSIS                                   |                                                                           |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                    1  1  1  1  1     1  2  2  1  1  2  1     1        1  1|          |
  NECROSIS                                  |                                                                           |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                        1                  |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                                3                                          |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                     2                 2   |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |     2                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1  1  1  1  1     1  1  1  1     1  1     1  1  1  1  2  2  1  1|          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   97
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:05.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 5| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 8| 6| 9| 6| 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 9| 1| 1| 8| 7| 3| 5| 5| 5| 5| 6| 6| 6| 6| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 2| 2| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|   S  R   R|
                                            | 8| 9| 7| 8| 0| 2| 9| 9| 9| 9| 3| 3| 3| 3| 4| 4| 4| 7| 7| 7| 6| 6| 6| 6| 6|   U  V   I|
CONTRL FS-2YR 11    11                      | 3| 3| 7| 7| 8| 9| 5| 6| 7| 8| 1| 2| 3| 4| 0| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1           1  1                    1           1     1   |          |
LACRIMAL GLAND                              | +  +  +  +  M  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                       2                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2              1  1  1     1        1  1  2     1  1  2           2  1|          |
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |              3                                                            |          |
  HYPERPLASIA,SQUAMOUS                      |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |          |
  CYST,RENAL TUBULE                         |  1                 1                    1        1                 1      |          |
  GLOMERULOSCLEROSIS                        |        3                                                                  |          |
  HYDRONEPHROSIS                            |           2  2                                                            |          |
  HYPERPLASIA,RENAL TUBULE                  |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1        1  1  1  1  1  2  1  1  1  2  2  1     1  1  1  1  1  1  1  1|          |
  MINERALIZATION                            |              2                                                            |          |
  NECROSIS,RENAL TUBULE                     |        3                                                                  |          |
  NEPHROPATHY                               |                                                     1  1  1               |          |
  VACUOLIZATION CYTOPLASMIC,RENAL TUBULE    |              1                                                            |          |
URINARY BLADDER                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROSIS,ADVENTITIA                       |              2                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1           1  1  1  1  1     1  1  1  1  1     1  1  2  2  2  1  1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   98
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +       | 45       |
GALLBLADDER                                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         1                                 |     3 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA,LYMPHOID                      |     3     3                 2     2                       3               |     6 2.5|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA,GOBLET CELL                   |                                                                           |     1 3.0|
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  FIBROSIS                                  |                                                                           |     1 3.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +       | 42       |
  ATROPHY                                   |                                                                           |     1 2.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERPLASIA,LYMPHOID                      |                                      2                                    |     1 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                X                                                          |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |                             1                                             |     5 1.2|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  1  1  1  1  1  1  1              2  1  1  1  1  1  2      |    42 1.2|
  INFLAMMATION                              |                                                                           |     1 1.0|
  NECROSIS                                  |  1  1  1  1  1  1  1     1     1     1  1  1  1  1     1  1  1  1  1      |    27 1.0|
  NECROSIS,COAGULATIVE                      |                                   3                                       |     2 2.0|
  TENSION LIPOIDOSIS                        | X     X     X        X        X  X  X  X     X  X  X                      |    19    |
  VACUOLIZATION CYTOPLASMIC                 |  1  1  1  1  1  2  2  2  1  1  2  2  1  2  1  2  1  1  1  1     1         |    31 1.2|
MESENTERY                                   |                                                 +                         |  2       |
  NECROSIS,FAT                              |                                                  4                        |     2 4.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                                                                           |     2 1.0|
  DEGENERATION                              |                                      1                                    |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1     1              1     2  1     1  1  1           1  1     2      |    24 1.0|
  INFLAMMATION                              |                                                                           |     1 2.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1  2  1     1  1  1     1  2  1  2  1  2  1  2  1  2  1  2  2  1      |    41 1.4|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:   99
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  HYPERKERATOSIS                            |                                                        2                  |     1 2.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CYST                                      |                                2  2                                1      |     5 1.6|
  HYPERPLASIA                               |        1                                                                  |     2 1.5|
  MINERALIZATION                            |                                                                           |     1 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,MAST CELL           |                                                           2               |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CARDIOMYOPATHY                            |                                                        1                  |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  THROMBUS                                  |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                          X                |     1    |
ADRENAL GLAND,CORTEX                        | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HEMATOPOIETIC CELL PROLIFERATION          |                             1                                             |     1 1.0|
  HYPERPLASIA,SPINDLE CELL                  |     2  2  2  3  2  2  1  3     2  2  3  1  2  1  2  2  3  1  2  2  1      |    44 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                  2                        |     1 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     1 2.0|
ADRENAL GLAND,MEDULLA                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFLAMMATION                              |                                                                           |     1 3.0|
  VACUOLIZATION CYTOPLASMIC                 |                                                                    2      |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
PARATHYROID GLAND                           | +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +       | 38       |
  CYST                                      |                                                                           |     1 2.0|
  ECTOPIC THYMUS                            |                                                                           |     2    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 3.0|
PITUITARY GLAND                             | +  +  +  +  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +       | 40       |
  CYTOMEGALY                                |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  100
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  DEGENERATION,CYSTIC,PARS DISTALIS         |                                                        2                  |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |  2                                                                        |     3 2.0|
  HYPERTROPHY,PARS DISTALIS                 |                                                                           |     2 1.5|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CYST,FOLLICLE                             |                                      2                                    |     1 2.0|
  ECTOPIC THYMUS                            |                                                                           |     1    |
  HYPERPLASIA,FOLLICULAR CELL               |                                         2                                 |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     2 1.0|
  INFLAMMATION                              |              1                                                            |     1 1.0|
  ULTIMOBRANCHIAL CYST                      |                    2  2  2     3  2        2  2  3     2        4  2      |    19 2.3|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M       | 38       |
  ATROPHY                                   |  3  4  3  4     4  4     3  4  3  3  4  2  3  4  3  3  3  3     4         |    37 3.3|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
  INFLAMMATION                              |                                1                                          |     1 1.0|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ANGIECTASIS                               |                                   2                                       |     1 2.0|
  ATROPHY                                   | X     X  X  X  X  X        X  X  X  X  X  X  X  X  X     X  X  X          |    37    |
  CONGESTION                                |                                                                           |     1 2.0|
  CYST                                      |                      X  X                          X                      |     9    |
  CYST,PERIOVARIAN TISSUE                   |    X                                            X     X     X             |    10    |
  HEMATOCYST                                |                               X                    X              X       |     4    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 2                                                         |     2 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |                                                                           |     1 2.0|
  ATROPHY                                   |                                                                           |     2 3.5|
  DILATATION                                |                                   3  3                                    |     4 3.5|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  1  2  2  2  2  2  3  2  3  2  2     2  1  2  3  3  3  3  2  3  2         |    40 2.1|
  INFLAMMATION                              |                                                                           |     1 2.0|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                         2                                 |     2 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  101
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA                               |                             3                                             |     3 2.6|
  MYELOFIBROSIS                             |                                                                           |     1 4.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA,LYMPHOID,BRONCHIAL            |                                                                 2         |     1 2.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |  3                       3                                2               |     8 2.3|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                                                           |     1 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                             1                                             |     1 1.0|
  HEMORRHAGE                                |                                                           2               |     2 2.0|
  HYPERPLASIA,LYMPHOID                      |                                   2     2                                 |     2 2.0|
  HYPERPLASIA,RETICULUM CELL                |     3                                                                     |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                  3                        |     1 3.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                                                           |     1 3.0|
  CONGESTION                                |              1                                               1            |     3 1.3|
  HEMATOPOIETIC CELL PROLIFERATION          |                       3     4                                             |     4 3.2|
  HYPERPLASIA,LYMPHOID                      |  4  3     3     2        2     2  2     1  1  3     2           3  2      |    21 2.2|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                     3                     |     1 3.0|
THYMUS                                      | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M       | 38       |
  ATROPHY,CORTEX                            |     3     2        2  2  2  4           3  3  4  2  2     2  3            |    27 2.8|
  CYST                                      |                                                  2                        |     1 2.0|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |  3                    2  2        3     1  3  1        2  1               |    16 2.1|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  LACTATION                                 |  1                                                                        |     1 1.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          2                                                |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  102
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FIBROUS OSTEODYSTROPHY                    |                             1           2     1  1     2     1            |    13 1.3|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  1  2  2  2  2  3  2        1        2  3  3  1  2  3  2  2  3  2  1      |    36 2.0|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     2 1.5|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  MINERALIZATION,THALAMUS                   |                                                     1                     |     1 1.0|
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEVELOPMENTAL MALFORMATION                |                                                                           |     1    |
  GLIOSIS                                   |                                                                 2         |     1 2.0|
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1  1     1  1     1  1           1  2  1     1  1  1  2  1     1  1      |    31 1.1|
  NECROSIS                                  |                                                                 2         |     1 2.0|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CONGESTION                                |                                                                           |     1 3.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |     2 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                     1                     |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2     1     1  1  1        1  2  2  2  1  1  1  2  1  2  2  2  2  2      |    40 1.3|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  103
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:19.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         S  R   R|
                                            | 6| 4| 4| 4| 5| 6| 6| 7| 1| 1| 1| 1| 2| 2| 2| 2| 9| 9| 9| 9| 9| 0| 0|         U  V   I|
CONTRL FS-2YR 11    11                      | 6| 7| 8| 9| 0| 8| 9| 0| 6| 7| 8| 9| 4| 5| 6| 7| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1              1  1     1  1                          1     1  2         |    14 1.0|
LACRIMAL GLAND                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +       | 41       |
  ATROPHY                                   |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1     1        1     1  2  2     1  1     2  1              1      |    25 1.2|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |                                                                           |     1 3.0|
  HYPERPLASIA,SQUAMOUS                      |              2                                                            |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                4                    4                     |     2 4.0|
  CYST,RENAL TUBULE                         |              1        1  1                    1           1               |    10 1.0|
  GLOMERULOSCLEROSIS                        |                             2                                             |     2 2.5|
  HYDRONEPHROSIS                            |                                                                           |     2 2.0|
  HYPERPLASIA,RENAL TUBULE                  |                          1                                                |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2  2  2  1  1  2  1        1  1  1  1  1  1  1  1  1     2  2  1      |    42 1.2|
  MINERALIZATION                            |                                                                           |     1 2.0|
  NECROSIS,RENAL TUBULE                     |                                                                           |     1 3.0|
  NEPHROPATHY                               |                                                  1  2  1           1      |     7 1.1|
  VACUOLIZATION CYTOPLASMIC,RENAL TUBULE    |                                                                           |     1 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROSIS,ADVENTITIA                       |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  2  1  1  1  1  2  2  2  1  1  1     1  2  2  1     1      |    41 1.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  104
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +                                                       |          |
  HYPERKERATOSIS                            |  2                                                                        |          |
GALLBLADDER                                 | +  +  +  +  +  +  +                                                       |          |
INTESTINE LARGE                             | A  +  +  +  +  +  +                                                       |          |
INTESTINE LARGE,CECUM                       | A  +  A  +  +  +  +                                                       |          |
  HYPERPLASIA,LYMPHOID                      |              2                                                            |          |
INTESTINE LARGE,COLON                       | A  +  +  +  +  +  +                                                       |          |
INTESTINE LARGE,RECTUM                      | A  +  +  +  +  +  +                                                       |          |
INTESTINE SMALL                             | A  +  A  +  +  +  +                    +  +                               |          |
INTESTINE SMALL,DUODENUM                    | A  +  A  +  +  +  +                    +                                  |          |
INTESTINE SMALL,ILEUM                       | A  +  A  +  +  +  +                                                       |          |
  HYPERPLASIA,LYMPHOID                      |                    2                                                      |          |
INTESTINE SMALL,JEJUNUM                     | A  +  A  +  +  +  +                       +                               |          |
  HYPERPLASIA,LYMPHOID                      |                    2                                                      |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  CYST,BILE DUCT                            |                                                                           |          |
  DEGENERATION                              |                    1                                                      |          |
  DEGENERATION,FATTY                        |                                         2                                 |          |
  EOSINOPHILIC FOCUS                        |                                                    X                      |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     2  1     2     1        1                 1                          3|          |
  HYPERPLASIA,KUPFFER CELL                  |              3     2                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1  1  2  1  1  1  1     2        1  1  2  1  1  1  1  1      |          |
  INFILTRATION CELLULAR,PLASMA CELL         |              1                                                            |          |
  NECROSIS                                  |              1  1     2  1  1  1  2     1           2  1  1  1  1     1   |          |
  NECROSIS,COAGULATIVE                      |                                                                    1      |          |
  REGENERATION                              |                                         2                                 |          |
  TENSION LIPOIDOSIS                        |                         X        X              X  X        X  X  X       |          |
  VACUOLIZATION CYTOPLASMIC                 |     1           2  1  1  2  2  1  2        2     2  2  2  1  2  1  1  1  1|          |
MESENTERY                                   |                               +        +                 +        +       |          |
  NECROSIS,FAT                              |                                4        4                 4               |          |
PANCREAS                                    | A  +  +  +  +  +  +                    +                                  |          |
  CYST,DUCT                                 |                                         4                                 |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1  1  1                                                      |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +                                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2  1  1  1  2                                                      |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  105
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

STOMACH                                     | A  +  +  +  +  +  +                                                       |          |
STOMACH,FORESTOMACH                         | A  +  +  +  +  +  +                                                       |          |
STOMACH,GLANDULAR                           | A  +  +  +  +  +  +                                                       |          |
  CYST                                      |                 1                                                         |          |
TONGUE                                      | +  +  +  +  +  +  +                                                       |          |
  MINERALIZATION                            |              2                                                            |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  M  +  +  +  +  +                                                       |          |
BLOOD VESSEL,AORTA                          | +  M  +  +  +  +  +                                                       |          |
HEART                                       | +  +  +  +  +  +  +                                                       |          |
  HYPERPLASIA,EPICARDIUM                    |     2                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +                          +                            |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +                                                       |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  2  2     1                                                      |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +                                                       |          |
ISLETS, PANCREATIC                          | A  +  +  +  +  +  +                                                       |          |
PARATHYROID GLAND                           | +  +  +  +  +  +  +                                                       |          |
PITUITARY GLAND                             | A  +  +  +  M  +  M                                                       |          |
THYROID GLAND                               | +  +  +  +  +  +  +                                                       |          |
  ULTIMOBRANCHIAL CYST                      |              3     2                                                      |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +                                                       |          |
  ATROPHY                                   |  3  3  3  3  2  2  4                                                      |          |
OVARY                                       | +  +  +  +  +  +  +  +     +  +           +  +                    +  +    |          |
  ATROPHY                                   |    X  X  X  X     X                                                       |          |
  CYST                                      |    X        X        X        X              X                            |          |
  CYST,PERIOVARIAN TISSUE                   |                            X                                         X    |          |
UTERUS                                      | +  +  +  +  +  +  +           +  +                 +     +  +  +     +  + |          |
  ATROPHY                                   |     3  4  4  2                                                            |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  106
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  DILATATION                                |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |                    1           3  2                       1  3  3     4  2|          |
VAGINA                                      | +  +  +  +  +  +  +                                                       |          |
  ATROPHY                                   |     3  3  4  4                                                            |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +                                                       |          |
  DEPLETION                                 |              2                                                            |          |
  HYPERPLASIA                               |                    3                                                      |          |
  MYELOFIBROSIS                             |     2                                                                     |          |
LYMPH NODE                                  | +  +  +  +  +  +  +                                               +     + |          |
  HYPERPLASIA,LYMPHOID,INGUINAL             |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +                                                       |          |
  HEMATOPOIETIC CELL PROLIFERATION          |           3                                                               |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  M  +  +                                               +       |          |
  ATROPHY                                   |        2  4                                                               |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                    3                                                      |          |
  HEMORRHAGE                                |                    3                                                      |          |
SPLEEN                                      | +  +  +  +  +  +  +        +              +     +     +     +  +        + |          |
  ATROPHY                                   |        3     3                                                            |          |
  CONGESTION                                |        1                                                                  |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  3     2     4                                                            |          |
  HYPERPLASIA,LYMPHOID                      |                 1                                      2                  |          |
THYMUS                                      | +  +  +  M  M  +  +                                                       |          |
  ATROPHY,CORTEX                            |                    3                                                      |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | A  +  +  M  +  +  +                                                       |          |
  HYPERPLASIA                               |        3                                                                  |          |
SKIN                                        | A  +  +  +  +  +  +                          +                            |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  107
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +                                                       |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +                                                       |          |
BONE,STERNUM                                | +  +  +  +  +  +  +                                                       |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |        2           2                                                      |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +                                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +                                                       |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +                                                       |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +                                                       |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     1  1     1     1                                                      |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +                                                       |          |
SPINAL CORD                                 | +  +  +  +  +  +  +                                                       |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +                                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  M  M  +  M  M  +                                                       |          |
LUNG                                        | +  +  +  +  +  +  +                                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 2  1                                                      |          |
NOSE                                        | +  +  +  +  +  +  +                                                       |          |
TRACHEA                                     | +  +  +  +  +  +  +                                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  A  A  +  +  +                                                       |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +                                                     + |          |
  HYPERPLASIA                               |              4                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                                  |          |
LACRIMAL GLAND                              | +  M  M  M  +  +  +                                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1  1                                                      |          |
ZYMBAL'S GLAND                              | M  +  +  +  +  +  +                                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  108
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:24.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 6| 6| 9| 0| 8| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 3| 8| 5| 8| 8| 2| 7| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 2| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6|   S  R   R|
                                            | 6| 8| 8| 9| 0| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 3| 3| 3| 3| 7| 7| 7| 5| 5| 5|   U  V   I|
10MG   FS-2YR 12    12                      | 9| 5| 6| 6| 0| 3| 7| 1| 2| 3| 4| 5| 6| 7| 8| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +                                                       |          |
  ACCUMULATION HYALINE DROPLET              |        4                                                                  |          |
  CYST,RENAL TUBULE                         |        1                                                                  |          |
  GLOMERULOSCLEROSIS                        |        3     3                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1        2  1  2                                                      |          |
URETER                                      |                                                                           |          |
URINARY BLADDER                             | +  +  +  +  +  +  +                                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1  1  1                                                      |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  109
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   |                                              M                            |  7       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
GALLBLADDER                                 |                                              +                            |  8       |
INTESTINE LARGE                             |                                              +                            |  7       |
INTESTINE LARGE,CECUM                       |                                              +                            |  6       |
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
INTESTINE LARGE,COLON                       |                                              +                            |  7       |
INTESTINE LARGE,RECTUM                      |                                              +                            |  7       |
INTESTINE SMALL                             |                                              +                            |  8       |
INTESTINE SMALL,DUODENUM                    |                                              +                            |  7       |
INTESTINE SMALL,ILEUM                       |                                              +                            |  6       |
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
INTESTINE SMALL,JEJUNUM                     |                                              +                            |  7       |
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |    X                                                                      |     1    |
  CYST,BILE DUCT                            |                                                                    2      |     1 2.0|
  DEGENERATION                              |                                                                           |     1 1.0|
  DEGENERATION,FATTY                        |                                                                           |     1 2.0|
  EOSINOPHILIC FOCUS                        |                         X                                                 |     2    |
  HEMATOPOIETIC CELL PROLIFERATION          |           1  1                    1        1     1                 1      |    13 1.3|
  HYPERPLASIA,KUPFFER CELL                  |                                                                           |     2 2.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1     1  1  1  1  1  1  1  1  1     1  1        2     1  1  2  1      |    35 1.1|
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |     1 1.0|
  NECROSIS                                  |  1  1  1  1  2     1     1  1  1  1  1  1  1     1  1  1  1  1     1      |    33 1.1|
  NECROSIS,COAGULATIVE                      |                                                                           |     1 1.0|
  REGENERATION                              |                                                                           |     1 2.0|
  TENSION LIPOIDOSIS                        |          X           X  X           X                    X  X  X          |    14    |
  VACUOLIZATION CYTOPLASMIC                 |  2  1  1  2  1  2  2  2     2  2  1  1  1  2     2     2  2     1         |    36 1.5|
MESENTERY                                   |                                                                           |  4       |
  NECROSIS,FAT                              |                                                                           |     3 4.0|
PANCREAS                                    |                                              +                            |  8       |
  CYST,DUCT                                 |                                                                           |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     5 1.0|
SALIVARY GLANDS                             |                                              +  +                         |  9       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     5 1.4|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  110
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

STOMACH                                     |                                              +                            |  7       |
STOMACH,FORESTOMACH                         |                                              +                            |  7       |
STOMACH,GLANDULAR                           |                                              +                            |  7       |
  CYST                                      |                                                                           |     1 1.0|
TONGUE                                      |                                              +                            |  8       |
  MINERALIZATION                            |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                |                                              +                            |  7       |
BLOOD VESSEL,AORTA                          |                                              +                            |  7       |
HEART                                       |                                              +                            |  8       |
  HYPERPLASIA,EPICARDIUM                    |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               |                                              +                            |  9       |
ADRENAL GLAND,CORTEX                        |                                              +                            |  8       |
  HYPERPLASIA,SPINDLE CELL                  |                                                                           |     4 1.7|
ADRENAL GLAND,MEDULLA                       |                                              +                            |  8       |
ISLETS, PANCREATIC                          |                                              +                            |  7       |
PARATHYROID GLAND                           |                                              M                            |  7       |
PITUITARY GLAND                             |                                              M                            |  4       |
THYROID GLAND                               |                                              +                            |  8       |
  ULTIMOBRANCHIAL CYST                      |                                                                           |     2 2.5|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              |                                              +                            |  8       |
  ATROPHY                                   |                                               3                           |     8 2.8|
OVARY                                       | +  +  +        +     +     +  +     +  +  +  +  +     +     +             | 28       |
  ATROPHY                                   |                                              X                            |     6    |
  CYST                                      |                X           X  X     X     X           X                   |    11    |
  CYST,PERIOVARIAN TISSUE                   | X  X  X              X                 X        X           X             |     9    |
UTERUS                                      | +  +           +  +     +  +  +  +        +  +  +           +  +  +       | 29       |
  ATROPHY                                   |                                               4                           |     5 3.4|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  111
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  DILATATION                                |                 4              3                                          |     2 3.5|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2  3              2     4  2     2        2     3           2  2  2      |    19 2.3|
VAGINA                                      |                                              +                            |  8       |
  ATROPHY                                   |                                               4                           |     5 3.6|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 |                                              +                            |  8       |
  DEPLETION                                 |                                                                           |     1 2.0|
  HYPERPLASIA                               |                                                                           |     1 3.0|
  MYELOFIBROSIS                             |                                                                           |     1 2.0|
LYMPH NODE                                  |             +                    +  +        +  +     +                   | 15       |
  HYPERPLASIA,LYMPHOID,INGUINAL             |                                      2                                    |     1 2.0|
LYMPH NODE,MANDIBULAR                       |             +                                +                            |  9       |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       |                                  +           +  +     +                   | 11       |
  ATROPHY                                   |                                                                           |     2 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     1 3.0|
  HEMORRHAGE                                |                                                                           |     1 3.0|
SPLEEN                                      |             +           +     +  +           +  +                         | 20       |
  ATROPHY                                   |                                                                           |     2 3.0|
  CONGESTION                                |                          2                                                |     2 1.5|
  HEMATOPOIETIC CELL PROLIFERATION          |              3                                                            |     4 3.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     2 1.5|
THYMUS                                      |                                              +                            |  6       |
  ATROPHY,CORTEX                            |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               |                                              +                            |  6       |
  HYPERPLASIA                               |                                                                           |     1 3.0|
SKIN                                        |                                              +                            |  8       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  112
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

BONE                                        |                                              +                            |  8       |
BONE,FEMUR                                  |                                              +                            |  8       |
BONE,STERNUM                                |                                              +                            |  8       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                                                                           |     2 2.0|
SKELETAL MUSCLE                             |                                              +                            |  8       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       |                                              +                            |  8       |
BRAIN,CEREBELLUM                            |                                              +                            |  8       |
BRAIN,CEREBRUM                              |                                              +                            |  8       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                                                                           |     4 1.0|
PERIPHERAL NERVE                            |                                              +                            |  8       |
SPINAL CORD                                 |                                              +                            |  8       |
SPINAL CORD,THORACIC                        |                                              +                            |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      |                                              +                            |  4       |
LUNG                                        |                                              +                            |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.5|
NOSE                                        |                                              +                            |  8       |
TRACHEA                                     |                                              +                            |  8       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         |                                              +                            |  5       |
HARDERIAN GLAND                             |                +                             +                            | 10       |
  HYPERPLASIA                               |                                                                           |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     2 1.0|
LACRIMAL GLAND                              |                                              +                            |  5       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     3 1.0|
ZYMBAL'S GLAND                              |                                              M                            |  6       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  113
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:26.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|         S  R   R|
                                            | 5| 5| 5| 6| 4| 4| 4| 6| 6| 5| 5| 5| 5| 5| 5| 8| 8| 8| 9| 9| 9| 9| 9|         U  V   I|
10MG   FS-2YR 12    12                      | 7| 8| 9| 0| 4| 5| 6| 6| 7| 3| 4| 5| 6| 7| 8| 0| 8| 9| 0| 1| 2| 3| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      |                                  +           +                            |  9       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     1 4.0|
  CYST,RENAL TUBULE                         |                                                                           |     1 1.0|
  GLOMERULOSCLEROSIS                        |                                                                           |     2 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     4 1.5|
URETER                                      |                                                 +                         |  1       |
URINARY BLADDER                             |                                              +                            |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     5 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  114
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:28.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|   S  R   R|
                                            | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7|   U  V   I|
25MG   FS-2YR 13    13                      | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  M                                                                   |          |
GALLBLADDER                                 | +  +  +                                                                   |          |
INTESTINE LARGE                             | +  +  +                                                                   |          |
INTESTINE LARGE,CECUM                       | +  A  A                                                                   |          |
INTESTINE LARGE,COLON                       | +  A  +                                                                   |          |
INTESTINE LARGE,RECTUM                      | +  +  M                                                                   |          |
INTESTINE SMALL                             | +  A  A                                                                   |          |
INTESTINE SMALL,DUODENUM                    | +  A  A                                                                   |          |
INTESTINE SMALL,ILEUM                       | +  A  A                                                                   |          |
INTESTINE SMALL,JEJUNUM                     | +  A  A                                                                   |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |        3                                                                  |          |
  BASOPHILIC FOCUS                          |                                                       X                   |          |
  DEGENERATION                              |                    3                                                      |          |
  EOSINOPHILIC FOCUS                        |                            X                                              |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                     1        1  1  1      |          |
  HYPERPLASIA,OVAL CELL                     |                    1                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2     2  1        2  1           3  1  1  1  1        2     1  1  1  1|          |
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                           |          |
  NECROSIS                                  |     1        1  1  1  2  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1|          |
  NECROSIS,COAGULATIVE                      |        3           3                             1                        |          |
  REGENERATION                              |                    3                                                      |          |
  TENSION LIPOIDOSIS                        |             X           X     X  X              X  X        X        X  X |          |
  THROMBUS                                  |        3                                                                  |          |
  VACUOLIZATION CYTOPLASMIC                 |                 3  2  2  3  3  3  2  1  2  3  2  2  1  2  2  2  2  2  2  2|          |
MESENTERY                                   |                                                                           |          |
PANCREAS                                    | +  +  A                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |          |
SALIVARY GLANDS                             | +  +  +                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  2                                                                  |          |
STOMACH                                     | +  A  +                                                                   |          |
STOMACH,FORESTOMACH                         | +  A  +                                                                   |          |
  HYPERKERATOSIS                            |  2                                                                        |          |
STOMACH,GLANDULAR                           | +  A  +                                                                   |          |
TONGUE                                      | +  +  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  115
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:29.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|   S  R   R|
                                            | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7|   U  V   I|
25MG   FS-2YR 13    13                      | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +                                                                   |          |
BLOOD VESSEL,AORTA                          | +  +  +                                                                   |          |
HEART                                       | +  +  +                                                                   |          |
  NECROSIS                                  |        1                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  M                                                                   |          |
ADRENAL GLAND,CORTEX                        | +  +  M                                                                   |          |
  HYPERPLASIA,SPINDLE CELL                  |  1                                                                        |          |
ADRENAL GLAND,MEDULLA                       | +  +  M                                                                   |          |
ISLETS, PANCREATIC                          | +  +  A                    +                                              |          |
PARATHYROID GLAND                           | M  M  M                                                                   |          |
PITUITARY GLAND                             | M  M  M                                                                   |          |
THYROID GLAND                               | +  +  M                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  M  M                                                                   |          |
  ATROPHY                                   |  4                                                                        |          |
OVARY                                       | +  +  M  +  +  +  +     +  +     +        +  +     +     +  +     +     + |          |
  ATROPHY                                   |    X                                                                      |          |
  CYST                                      |          X        X     X        X        X        X              X     X |          |
  CYST,PERIOVARIAN TISSUE                   |             X  X           X                 X           X  X             |          |
  HEMATOCYST                                |                                                                           |          |
UTERUS                                      | +  +  +     +     +  +           +     +  +     +  +     +     +  +  +    |          |
  ATROPHY                                   |  4     4                                                                  |          |
  DILATATION                                |  2                 4                                      4           2   |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              3                    3     2  2     2  3           3  2      |          |
  INFLAMMATION                              |                                                                           |          |
VAGINA                                      | +  M  M                                                                   |          |
  ATROPHY                                   |  4                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  116
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:29.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|   S  R   R|
                                            | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7|   U  V   I|
25MG   FS-2YR 13    13                      | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  A  A                                                                   |          |
LYMPH NODE                                  | +  +  +              +                                +                   |          |
LYMPH NODE,MANDIBULAR                       | +  +  +                                                                   |          |
LYMPH NODE,MESENTERIC                       | +  +  M                                               +                   |          |
SPLEEN                                      | +  +  +                    +                    +     +                   |          |
  ATROPHY                                   |        2                                                                  |          |
  CONGESTION                                |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |        3                                                                  |          |
  HYPERPLASIA,LYMPHOID                      |                             3                                             |          |
THYMUS                                      | +  +  M                                         +                         |          |
  ATROPHY,CORTEX                            |     2                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  M                                                                   |          |
SKIN                                        | +  +  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +                                                                   |          |
BONE,FEMUR                                  | +  M  +                                                                   |          |
BONE,STERNUM                                | +  +  +                                                                   |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |     3                                                                     |          |
SKELETAL MUSCLE                             | +  +  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +                                                                   |          |
BRAIN,CEREBELLUM                            | +  +  +                                                                   |          |
BRAIN,CEREBRUM                              | +  +  +                                                                   |          |
PERIPHERAL NERVE                            | +  +  +                                                                   |          |
SPINAL CORD                                 | +  +  +                                                                   |          |
SPINAL CORD,THORACIC                        | +  +  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  117
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:29.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 7| 5| 2| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 1| 1| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|   S  R   R|
                                            | 0| 0| 0| 8| 8| 8| 9| 9| 9| 9| 9| 4| 4| 4| 4| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7|   U  V   I|
25MG   FS-2YR 13    13                      | 8| 9| 7| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 3| 4| 5| 6| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M                                                                   |          |
LUNG                                        | +  +  +                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2  1                                                                  |          |
NOSE                                        | +  +  +                                                                   |          |
TRACHEA                                     | +  +  M                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  A  A                                                                   |          |
HARDERIAN GLAND                             | +  +  +                                         +                         |          |
  HYPERPLASIA                               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1                                                                  |          |
LACRIMAL GLAND                              | +  +  M                                                                   |          |
ZYMBAL'S GLAND                              | M  M  +                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1                                                                  |          |
URINARY BLADDER                             | +  +  M                                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  118
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:30.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
25MG   FS-2YR 13    13                      | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   |                                                                           |  2       |
GALLBLADDER                                 |                                                                           |  3       |
INTESTINE LARGE                             |                                                                           |  3       |
INTESTINE LARGE,CECUM                       |                                                                           |  1       |
INTESTINE LARGE,COLON                       |                                                                           |  2       |
INTESTINE LARGE,RECTUM                      |                                                                           |  2       |
INTESTINE SMALL                             |                               +                                           |  2       |
INTESTINE SMALL,DUODENUM                    |                                                                           |  1       |
INTESTINE SMALL,ILEUM                       |                                                                           |  1       |
INTESTINE SMALL,JEJUNUM                     |                               +                                           |  2       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |                                                                           |     1 3.0|
  BASOPHILIC FOCUS                          |                                              X                            |     2    |
  DEGENERATION                              |                                                                           |     1 3.0|
  EOSINOPHILIC FOCUS                        |                                                                           |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |  1  1           1  1  1              1        1                 1  1      |    13 1.0|
  HYPERPLASIA,OVAL CELL                     |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1  1  1  1  1  1  1  2  1  2  1  1  1  1  1  1  1  1  2      |    36 1.2|
  INFILTRATION CELLULAR,PLASMA CELL         |                                                                 1         |     1 1.0|
  NECROSIS                                  |  1  1  1  1  1     1  1  1  1  1  1     1  1     1  2  1  1     1         |    40 1.0|
  NECROSIS,COAGULATIVE                      |        2                                                                  |     4 2.2|
  REGENERATION                              |                                                                           |     1 3.0|
  TENSION LIPOIDOSIS                        |    X     X  X  X                    X     X  X  X  X  X     X             |    20    |
  THROMBUS                                  |                                                                           |     1 3.0|
  VACUOLIZATION CYTOPLASMIC                 |  2  1  1  1  2  2  1  1  2  2  1  1  2  2  1  2  2  3  2  2  1     2      |    42 1.8|
MESENTERY                                   |                   +                                                       |  1       |
PANCREAS                                    |                                                                           |  2       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
SALIVARY GLANDS                             |                                                                           |  3       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     3 1.3|
STOMACH                                     |                                                                           |  2       |
STOMACH,FORESTOMACH                         |                                                                           |  2       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
STOMACH,GLANDULAR                           |                                                                           |  2       |
TONGUE                                      |                                                                           |  3       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  119
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:30.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
25MG   FS-2YR 13    13                      | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                |                                                                           |  3       |
BLOOD VESSEL,AORTA                          |                                                                           |  3       |
HEART                                       |                                                                           |  3       |
  NECROSIS                                  |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               |                                                                           |  2       |
ADRENAL GLAND,CORTEX                        |                                                                           |  2       |
  HYPERPLASIA,SPINDLE CELL                  |                                                                           |     1 1.0|
ADRENAL GLAND,MEDULLA                       |                                                                           |  2       |
ISLETS, PANCREATIC                          |                                                                           |  3       |
PARATHYROID GLAND                           |                                                                           |  0       |
PITUITARY GLAND                             |                                                                           |  0       |
THYROID GLAND                               |                                                                           |  2       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              |                                                                           |  1       |
  ATROPHY                                   |                                                                           |     1 4.0|
OVARY                                       | +  +  +  +  +        +  +     +              +           +  +  +          | 28       |
  ATROPHY                                   |                                                                           |     1    |
  CYST                                      |       X  X  X        X        X              X           X  X  X          |    17    |
  CYST,PERIOVARIAN TISSUE                   | X                                                                         |     7    |
  HEMATOCYST                                |                         X                                                 |     1    |
UTERUS                                      | +  +  +        +     +        +  +     +        +  +  +  +  +             | 28       |
  ATROPHY                                   |                                                                           |     2 4.0|
  DILATATION                                |     3           4     3                                2                  |     8 3.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  2     3                       2  4     2        2  4     2  2            |    17 2.5|
  INFLAMMATION                              |                 2                                                         |     1 2.0|
VAGINA                                      |                                                                           |  1       |
  ATROPHY                                   |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  120
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:30.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
25MG   FS-2YR 13    13                      | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 |                                                                           |  1       |
LYMPH NODE                                  |                +                                                          |  6       |
LYMPH NODE,MANDIBULAR                       |                +                                                          |  4       |
LYMPH NODE,MESENTERIC                       |                +                                                          |  4       |
SPLEEN                                      | +        +  +  +  +  +              +                          +  +       | 15       |
  ATROPHY                                   |                                                                           |     1 2.0|
  CONGESTION                                |           1                                                               |     1 1.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                 4         |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |              2        1              3                                    |     4 2.2|
THYMUS                                      |                +                                                          |  4       |
  ATROPHY,CORTEX                            |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               |                                                                           |  2       |
SKIN                                        | +                 +                                            +          |  6       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        |                                                                           |  3       |
BONE,FEMUR                                  |                                                                           |  2       |
BONE,STERNUM                                |                                                                           |  3       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                                                                           |     1 3.0|
SKELETAL MUSCLE                             |                                                                           |  3       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       |                                                                           |  3       |
BRAIN,CEREBELLUM                            |                                                                           |  3       |
BRAIN,CEREBRUM                              |                                                                           |  3       |
PERIPHERAL NERVE                            |                                                                           |  3       |
SPINAL CORD                                 |                                                                           |  3       |
SPINAL CORD,THORACIC                        |                                                                           |  3       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  121
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:30.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 7| 0| 0| 0| 0| 0| 0| 0| 0| 6| 6| 6| 6| 7| 7| 7| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
25MG   FS-2YR 13    13                      | 9| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

LARYNX                                      |                                                                           |  2       |
LUNG                                        |          +                                                                |  4       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.5|
NOSE                                        |                                                                           |  3       |
TRACHEA                                     |                                                                           |  2       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         |                                                                           |  0       |
HARDERIAN GLAND                             |       +                                                                   |  5       |
  HYPERPLASIA                               |        4                                                                  |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.0|
LACRIMAL GLAND                              |                                                                           |  2       |
ZYMBAL'S GLAND                              |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      |                                                                           |  3       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.0|
URINARY BLADDER                             |                                                                           |  2       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  122
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |     2                                                                     |          |
GALLBLADDER                                 | M  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET              |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
INTESTINE LARGE                             | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,COLON                       | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,GOBLET CELL                   |                       2                                                   |          |
INTESTINE LARGE,RECTUM                      | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL                             | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | A  +  +  A  M  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,ILEUM                       | A  +  +  A  +  A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                          1                                   2            |          |
INTESTINE SMALL,JEJUNUM                     | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  DEGENERATION                              |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     2           1                                                        1|          |
  HYPERPLASIA,KUPFFER CELL                  |              3                                                            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1     3     1  1  1  1  2  1     1  2  2     1  1  1  1  1|          |
  INFLAMMATION                              |                                            1                              |          |
  NECROSIS                                  |        1     1        1  1  1  1  1  1     1     1  1  1  1  1  3     1  1|          |
  NECROSIS,COAGULATIVE                      |              1                                                            |          |
  TENSION LIPOIDOSIS                        |                         X     X                       X  X     X  X  X    |          |
  THROMBUS                                  |              1                                                            |          |
  VACUOLIZATION CYTOPLASMIC                 |     1  4  4                    2  1  2  1           2     2  2  1  2  2  2|          |
PANCREAS                                    | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET,DUCT         |                                                                           |          |
  DEGENERATION                              |     1                                                                     |          |
  FOCAL CELLULAR CHANGE                     |              1                                                            |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |     2                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1  1  1        2     1           1  2     1  1     2           1   |          |
  NECROSIS                                  |     1                                                                     |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  123
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |  2                                                              2         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2  1  1  2  1  2  1  1  1  1     2  2     2  1  1  1  1  2  1  1  2|          |
STOMACH                                     | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERKERATOSIS                            |        2                                                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |                                                                           |          |
STOMACH,GLANDULAR                           | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  INFLAMMATION                              |                                                                           |          |
  MINERALIZATION                            |                                      1                                    |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  POLYARTERITIS                             |                                                                 2         |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  + |          |
BLOOD VESSEL,AORTA                          | +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,VALVE                        |                                                                       1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          1                                                |          |
  NECROSIS                                  |           2                                                               |          |
  POLYARTERITIS                             |                                                                 2         |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |        2  2  2  1     2  1  1  2  2  2  2  1     2  2  1  2  2  2     1   |          |
  VACUOLIZATION CYTOPLASMIC                 |                                      2                 1                  |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  + |          |
ISLETS, PANCREATIC                          | A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                        2                  |          |
PARATHYROID GLAND                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M |          |
  ECTOPIC THYMUS                            |                                                 X                         |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  124
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                  1                        |          |
PITUITARY GLAND                             | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |              3     3  1                                   2        2  1   |          |
  POLYARTERITIS                             |                                                                 2         |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |                       2                                                   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            1                              |          |
  POLYARTERITIS                             |                                                                 2         |          |
  ULTIMOBRANCHIAL CYST                      |        2     2        3  2        3  3     2           3     2        2   |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  M  +  +  M  +  +  M  M  +  M  M  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |     4  3  3        4  2     2  3        2           4  1  3  3     3  2  3|          |
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |    X  X  X  X     X        X  X  X  X  X  X     X  X  X     X  X  X  X    |          |
  CYST                                      |                      X     X        X     X           X                   |          |
  CYST,PERIOVARIAN TISSUE                   |                X                                                          |          |
  HEMATOCYST                                |                                                                      X    |          |
  MINERALIZATION                            |                                                                           |          |
UTERUS                                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |  4                                   3        4                    3      |          |
  DILATATION                                |                    4              4                                       |          |
  FIBROSIS                                  |              3                                                            |          |
  HEMORRHAGE                                |              4                                                            |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2  2     2  1  1  3        4  4     2  2  2  3  2  2     1  2|          |
  INFLAMMATION                              |                                                                           |          |
VAGINA                                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  + |          |
  ATROPHY                                   |                    4                          4                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                      1                                    |          |
  POLYARTERITIS                             |                                                                 3         |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  125
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |     4                                                                     |          |
  INFARCT                                   |                                                                           |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                  2                        |          |
  HYPERPLASIA,LYMPHOID                      |                 2                                                         |          |
LYMPH NODE,MESENTERIC                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  ATROPHY                                   |                                                        1                  |          |
  HEMORRHAGE                                |              2                                                            |          |
  HYPERPLASIA,LYMPHOID                      |                 2                                                         |          |
SPLEEN                                      | A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |              3                                                            |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     4        4        2           2        2           2                  |          |
  HYPERPLASIA,LYMPHOID                      |        3        2           2  1  1                 3     3  2     2      |          |
  INFARCT                                   |                                      1                                    |          |
THYMUS                                      | M  +  +  M  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  + |          |
  ATROPHY,CORTEX                            |     2  3     4  4     3           2        3     4  3     2  2     3     3|          |
  CONGESTION                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |     2  2                    2        1     2           1  2  2     2     3|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |              2                                                            |          |
  LACTATION                                 |              3                                                            |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,TURBINATE          |                                                        1              1   |          |
BONE,FEMUR                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                          1           1  1              1        2        1|          |
BONE,STERNUM                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  126
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:45.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                          1  1  2     2  3  2        2  1  1  2  2     1  2|          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1  1  1  1  1  1  1  1        1  2  1  2        1  1  2     1  1   |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  + |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |           4                                                               |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                          1  1                                             |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1     1  1     1  1  2  1  1  1  2  1     1  1  1  2  1  1     1  1|          |
  INFLAMMATION                              |     1                                                                     |          |
NOSE                                        | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FOCAL CELLULAR CHANGE                     |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION,CORNEA                       |                                                                           |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                 1     2  1              1           1        1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  127
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:46.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 5| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 5| 0| 4| 4| 0| 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 8| 2| 4| 7| 0| 8| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 1| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|   S  R   R|
                                            | 3| 6| 6| 7| 7| 0| 2| 7| 8| 8| 8| 8| 8| 8| 8| 2| 4| 4| 4| 7| 7| 7| 7| 6| 6|   U  V   I|
50MG   FS-2YR 14    14                      | 9| 3| 4| 1| 0| 5| 3| 9| 0| 1| 2| 3| 4| 5| 6| 3| 3| 4| 5| 6| 7| 8| 9| 7| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

LACRIMAL GLAND                              | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     2  1     2     2     1  1        1  2     2  1  1        2        2|          |
ZYMBAL'S GLAND                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                            2                              |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET              |     3                                                                     |          |
  CYST,RENAL TUBULE                         |                    1     1                                                |          |
  GLOMERULOSCLEROSIS                        |                                                                           |          |
  HYDRONEPHROSIS                            |     1                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1  1  1  1  1  1     1  1  1  3  1  1     1  1  1  1     1  1  1  1|          |
  MINERALIZATION                            |        1                                                                  |          |
  NEPHROPATHY                               |                                                                           |          |
  PIGMENTATION,RENAL TUBULE                 |  3                                                                        |          |
URINARY BLADDER                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2        1     2  1  1  1  1  1  1  1     1  2  1  1  1  2        1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  128
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:58.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +       | 44       |
  ACCUMULATION HYALINE DROPLET              |                                         2                                 |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     2 1.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE LARGE,CECUM                       | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,LYMPHOID                      |                                1                                          |     1 1.0|
INTESTINE LARGE,COLON                       | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,GOBLET CELL                   |                                                                           |     1 2.0|
INTESTINE LARGE,RECTUM                      | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M       | 41       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,LYMPHOID                      |                                            1                 2            |     4 1.5|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |             X                                                             |     1    |
  DEGENERATION                              |                             3                                             |     1 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |     1     1     1        1  1        2     1        1                     |    11 1.1|
  HYPERPLASIA,KUPFFER CELL                  |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1           1  1  1  1     1  1  1  1  1     3  1  1  1  1  1  1         |    33 1.2|
  INFLAMMATION                              |                                                                           |     1 1.0|
  NECROSIS                                  |  1  1  1  1  1  1  1                    1  1  2  1  1  1  1  1  1  1      |    34 1.0|
  NECROSIS,COAGULATIVE                      |                          3  1                                             |     3 1.6|
  TENSION LIPOIDOSIS                        | X  X     X        X              X     X                    X  X  X       |    16    |
  THROMBUS                                  |                                                                           |     1 1.0|
  VACUOLIZATION CYTOPLASMIC                 |  2  2  2  2     2  2  2     3  2  2  2  1  2  1  1  2  2     2  2  3      |    34 1.9|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ACCUMULATION HYALINE DROPLET,DUCT         |                                         2                                 |     1 2.0|
  DEGENERATION                              |                                                                           |     1 1.0|
  FOCAL CELLULAR CHANGE                     |                                                                 1         |     2 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1        1  1     1     1        1  1  1            |    20 1.1|
  NECROSIS                                  |                                                                           |     1 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  129
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:58.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  ATROPHY                                   |                                                                           |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2     1  1  1  1  1  1  1  1  1  2  1  1  1  2     1  1  1  2         |    41 1.2|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         2                                 |     1 2.0|
  INFLAMMATION                              |                                         1     1                           |     2 1.0|
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         2                                 |     1 2.0|
  INFLAMMATION                              |                                         1                                 |     1 1.0|
  MINERALIZATION                            |                                                        1                  |     2 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  POLYARTERITIS                             |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION,VALVE                        |                                1  1              2                        |     4 1.2|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  NECROSIS                                  |                                                                           |     1 2.0|
  POLYARTERITIS                             |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +       | 46       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +       | 46       |
  HYPERPLASIA                               |              1                                                            |     1 1.0|
  HYPERPLASIA,SPINDLE CELL                  |  2  1     1        1  1  1  1  1  1  1  1  1  1  1  1     1  1  1  1      |    38 1.3|
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |     2 1.5|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +       | 44       |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  HYPERPLASIA                               |                                   1                                       |     2 1.5|
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ECTOPIC THYMUS                            |                                                                           |     1    |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  130
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:58.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
PITUITARY GLAND                             | +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +       | 42       |
  ANGIECTASIS                               |                                                           1               |     1 1.0|
  HYPERPLASIA,PARS DISTALIS                 |                                                        1  1               |     8 1.7|
  POLYARTERITIS                             |                                                                           |     1 2.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               1                           |     2 1.0|
  POLYARTERITIS                             |                                                                           |     1 2.0|
  ULTIMOBRANCHIAL CYST                      |        2        2        2  2  3  3           2        2  2     2         |    20 2.3|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  M  M  +  +       | 37       |
  ATROPHY                                   |  3     3  3  2  2     2  2  2     1     1           2  1        2  2      |    29 2.4|
OVARY                                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  ANGIECTASIS                               |        3                                                                  |     1 3.0|
  ATROPHY                                   | X     X  X  X     X        X  X  X  X  X  X  X  X           X     X       |    33    |
  CYST                                      | X  X  X           X  X     X              X                    X          |    13    |
  CYST,PERIOVARIAN TISSUE                   |                                     X              X                      |     3    |
  HEMATOCYST                                |                                                       X  X                |     3    |
  MINERALIZATION                            |        2                                                                  |     1 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                                                                           |     4 3.5|
  DILATATION                                |                                                           1               |     3 3.0|
  FIBROSIS                                  |                                                     2                     |     2 2.5|
  HEMORRHAGE                                |                                                                           |     1 4.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  3  2  3  2  1  2  4  2  1  2  2  1  1  1  4  1  1  3  2     3  1  2      |    38 2.0|
  INFLAMMATION                              |     1                                                                     |     1 1.0|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                                                                           |     2 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     2 1.0|
  POLYARTERITIS                             |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  131
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:59.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  HYPERPLASIA                               |                             3                                             |     2 3.5|
  INFARCT                                   |                X                                                          |     1    |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
LYMPH NODE,MANDIBULAR                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |  3                                                                 1      |     3 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +       | 43       |
  ATROPHY                                   |                                                                           |     1 1.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                                                                           |     1 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                 2           3                    2                        |     9 2.5|
  HYPERPLASIA,LYMPHOID                      |                    2                 3                          2         |    12 2.1|
  INFARCT                                   |                                                                           |     1 1.0|
THYMUS                                      | +  +  +  +  +  M  M  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +       | 37       |
  ATROPHY,CORTEX                            |  4        2                                                               |    15 2.9|
  CONGESTION                                |     2                                                                     |     1 2.0|
  HYPERPLASIA,LYMPHOID,MEDULLA              |           2  2        1        2  2  1  2     1  1     2  2  2            |    22 1.7|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
  LACTATION                                 |                          1        1                 1  2                  |     5 1.6|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROUS OSTEODYSTROPHY,TURBINATE          |                       1                    1  1     1  1     1  1  2      |    10 1.1|
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FIBROUS OSTEODYSTROPHY                    |  2        2                                                  1            |     9 1.3|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  132
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:59.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |  1  1  2  2     1  1  1  1     1     2  1  1  2  2  2  1  2  2  1  1      |    33 1.5|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         1        1                        |     2 1.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                1                                       |     2 1.0|
  MINERALIZATION,MULTIFOCAL,THALAMUS        |     1           1  1        1  2           1     1                        |    24 1.1|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CONGESTION                                |                                                                           |     1 4.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                               1                           |     1 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     2 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2     1  1  1     1  1  1  1  2  1  1     3  2     1  1  1  2  1      |    38 1.2|
  INFLAMMATION                              |                                                                           |     1 1.0|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FOCAL CELLULAR CHANGE                     |                          1                                                |     1 1.0|
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFLAMMATION,CORNEA                       |                                               1                           |     1 1.0|
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |                                                     1                     |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1     1           1     1  1     1                                 |    16 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  133
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:37:59.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
                                            | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|         S  R   R|
                                            | 6| 7| 7| 7| 9| 9| 9| 9| 0| 0| 5| 6| 6| 6| 6| 6| 6| 1| 1| 1| 2| 2| 2|         U  V   I|
50MG   FS-2YR 14    14                      | 9| 0| 1| 2| 6| 7| 8| 9| 0| 1| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +       | 43       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  2     1  1  1     1        1     3        1           1  1  2         |    26 1.4|
ZYMBAL'S GLAND                              | +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +       | 45       |
  INFLAMMATION                              |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     1 3.0|
  CYST,RENAL TUBULE                         |                                                                           |     2 1.0|
  GLOMERULOSCLEROSIS                        |     1                                                                     |     1 1.0|
  HYDRONEPHROSIS                            |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  1  1  1     1        1  1  1  1  1  1  1  1  1        2  1  1  1      |    39 1.1|
  MINERALIZATION                            |                                                                           |     1 1.0|
  NEPHROPATHY                               |                                                  2     1                  |     2 1.5|
  PIGMENTATION,RENAL TUBULE                 |                                                                           |     1 3.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1     1  1  1  1  1  1     1  1  1  1  1     1  1  1  1  2  2  2  1      |    37 1.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  134
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:12.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  HYPERKERATOSIS                            |                                            2                       2      |          |
GALLBLADDER                                 | M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 1           1                                             |          |
INTESTINE LARGE                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
INTESTINE LARGE,CECUM                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                   2     2                                 |          |
INTESTINE LARGE,COLON                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
  HYPERPLASIA,LYMPHOID                      |                                                                           |          |
INTESTINE LARGE,RECTUM                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
INTESTINE SMALL                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
INTESTINE SMALL,DUODENUM                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
INTESTINE SMALL,ILEUM                       | A  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
INTESTINE SMALL,JEJUNUM                     | A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                  X                                        |          |
  EOSINOPHILIC FOCUS                        |                                                       X                   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                      1     1                              |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2     1     1  1  1        1  1     1     1  1  1  1  1           1   |          |
  INFLAMMATION                              |                                                                           |          |
  NECROSIS                                  |     1     1     1  1  1  1     1  1     1  1  1  1  1     1  1  1     2   |          |
  TENSION LIPOIDOSIS                        |                X     X        X  X              X  X  X  X                |          |
  VACUOLIZATION CYTOPLASMIC                 |     2     1     1              1  1     1     1  1  1     1  2        1  1|          |
MESENTERY                                   |                                                             +             |          |
  NECROSIS,FAT                              |                                                              4            |          |
PANCREAS                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  FOCAL CELLULAR CHANGE                     |                                                              1            |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1        1  1  2        1  1  1  1  1  1  1  1     1  1        1  1|          |
  INFLAMMATION                              |                                                                           |          |
SALIVARY GLANDS                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                          2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1  1  1  1  2  1     1  1     1  1  1  1  2  1  2  1        1  2|          |
STOMACH                                     | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
STOMACH,FORESTOMACH                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  HYPERKERATOSIS                            |                                                                           |          |
STOMACH,GLANDULAR                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  135
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:12.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CYST                                      |                                                                           |          |
TONGUE                                      | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION                              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,ARTERY                       |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                                                           |          |
  FOCAL CELLULAR CHANGE                     |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |     2  2  3  1  3  2  2  2  3  2  2  2  1  2  2  1  2  2  2  2     2  1  1|          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ADRENAL GLAND,MEDULLA                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FOCAL CELLULAR CHANGE                     |                                                                          2|          |
  VACUOLIZATION CYTOPLASMIC                 |                                                                           |          |
ISLETS, PANCREATIC                          | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                    1                                                      |          |
PARATHYROID GLAND                           | A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  CYST                                      |                                                                           |          |
  ECTOPIC THYMUS                            |                      X                                                    |          |
PITUITARY GLAND                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  + |          |
  ECTASIA                                   |                                      1                                    |          |
  HYPERPLASIA,PARS DISTALIS                 |                 1                                                     3   |          |
THYROID GLAND                               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  CYST,FOLLICLE                             |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                    2           1                                          |          |
  ULTIMOBRANCHIAL CYST                      |              2              3  2     2     4     2                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  136
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:12.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

CLITORAL GLAND                              | A  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  M  +  M  M  +  + |          |
  ATROPHY                                   |     4  2  3  3  3  3  3  3  3  4     3     4  3  3  4        3        4  3|          |
  INFLAMMATION                              |                                                                           |          |
OVARY                                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  ATROPHY                                   |          X     X     X  X  X  X  X  X     X  X  X     X  X     X          |          |
  CYST                                      |          X  X     X                             X  X  X  X                |          |
  CYST,PERIOVARIAN TISSUE                   |                                                                         X |          |
  HEMATOCYST                                |                            X                                X             |          |
  HYPERPLASIA,ADENOMATOUS                   |                                                                           |          |
  HYPERPLASIA,TUBULAR                       |                                            2                              |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           2                                                               |          |
  OVOTESTIS                                 |                                                                           |          |
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  ATROPHY                                   |        3  3                                                     3        2|          |
  DILATATION                                |        2                                                                  |          |
  ECTASIA,VEIN                              |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |              2  2  2  3  3  3  2  2  3  3  2  3  3  3  2  3  3            |          |
  METAPLASIA,SQUAMOUS                       |                                                                           |          |
  THROMBUS                                  |                                                                           |          |
VAGINA                                      | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
  ATROPHY                                   |                                                                          2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               2                           |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |     3                                                                     |          |
  HYPERPLASIA,LYMPHOID                      |                                2                                          |          |
LYMPH NODE                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,LYMPHOID,AXILLARY             |                                                                           |          |
LYMPH NODE,MANDIBULAR                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                    3     2|          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |                 2        3                                      4         |          |
LYMPH NODE,MESENTERIC                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  137
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:12.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  ATROPHY                                   |                    2                                   3                  |          |
  HYPERPLASIA,LYMPHOID                      |                                                                 2         |          |
SPLEEN                                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                                                                       2   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     3  3                                                        3     2   |          |
  HYPERPLASIA,LYMPHOID                      |     3     4     3  3           2              2  1     3  4               |          |
  INFARCT                                   |                                                                           |          |
  NECROSIS                                  |                                                                          1|          |
THYMUS                                      | M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  + |          |
  ATROPHY,CORTEX                            |     4           3  3  3  3        4     2        4  3     2  2        4  4|          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |     2           2  2                    2        2                        |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  A  +  + |          |
  HYPERPLASIA                               |        2                                                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
SKIN                                        | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,CARTILAGE                    |                                                                           |          |
  FIBROUS OSTEODYSTROPHY                    |                          1  1  2     2  2  2  2  1  1     1  1            |          |
BONE,STERNUM                                | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                 2  2  3  1  2  2  1  1  2  3     1  2  2  1  3            |          |
SKELETAL MUSCLE                             | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,THALAMUS                   |                    1                                                      |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  138
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:13.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

  MINERALIZATION,MULTIFOCAL,THALAMUS        |        1     1  1  1  1  1  1  1     2  1     1  1  1  1  1        1     1|          |
PERIPHERAL NERVE                            | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  + |          |
  DEMYELINATION                             |                                                                           |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,AXON                         |                             2                                             |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                1                                          |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  + |          |
LUNG                                        | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                                                                    3      |          |
  EDEMA                                     |                                            1                              |          |
  HEMORRHAGE                                |                                                                       1   |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                            2                              |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1     1  2  1  1     1  1           1  2  1  1                 1|          |
  INFLAMMATION                              |                                         1                                 |          |
  PIGMENTATION,HEMOSIDERIN                  |                                                                           |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYTOPLASMIC ALTERATION,RESPIRATORY EPITHEL|           2                                                               |          |
    IUM                                     |                                                                           |          |
TRACHEA                                     | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  + |          |
HARDERIAN GLAND                             | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  + |          |
  ECTASIA                                   |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1           1  1     1           1  1  1     1  1               |          |
LACRIMAL GLAND                              | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  + |          |
  ATROPHY                                   |                                                  1                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1           1  1  1           1     1  1     1     2     1            |          |
ZYMBAL'S GLAND                              | A  +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  139
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:13.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 3| 6| 6|
                                            | 7| 2| 3| 7| 9| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 8| 5| 5|
                                            | 8| 6| 3| 3| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 3| 3| 3| 3| 7| 8| 6| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|   S  R   R|
                                            | 5| 7| 8| 8| 9| 1| 1| 4| 4| 4| 7| 7| 7| 7| 0| 0| 0| 4| 4| 4| 4| 6| 6| 9| 9|   U  V   I|
CONTRL FS-2YR 19    19                      | 7| 3| 1| 7| 5| 5| 6| 4| 5| 6| 3| 4| 5| 6| 4| 5| 6| 5| 6| 7| 8| 6| 9| 3| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                    3      |          |
  CYST,RENAL TUBULE                         |                                         1     1  1  1        1     1     1|          |
  GLOMERULOSCLEROSIS                        |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1        3  1  1  1  1  1  1  1  1  2  1  2  1  1  1        1  1|          |
  NEPHROPATHY                               |           1                                                               |          |
  PIGMENTATION,RENAL TUBULE                 |                                                                           |          |
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1  1  1  1  3     1  1  1  1  1     1  1  1  1              1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  140
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +       | 45       |
  HYPERKERATOSIS                            |                                                                           |     2 2.0|
GALLBLADDER                                 | A  +  +  +  +  +  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +       | 41       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       1                             1                     |     4 1.0|
INTESTINE LARGE                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE LARGE,CECUM                       | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA,LYMPHOID                      |           3                       3                                       |     4 2.5|
INTESTINE LARGE,COLON                       | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  HYPERPLASIA,LYMPHOID                      |                                2                                          |     1 2.0|
INTESTINE LARGE,RECTUM                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE SMALL                             | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
INTESTINE SMALL,DUODENUM                    | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
INTESTINE SMALL,ILEUM                       | A  A  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 40       |
INTESTINE SMALL,JEJUNUM                     | A  A  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +       | 41       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                X                                                          |     2    |
  EOSINOPHILIC FOCUS                        |                                                                           |     1    |
  HEMATOPOIETIC CELL PROLIFERATION          |                                            1           1                  |     4 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1        1  1        1  1  1  1  1  1  1  1  1  2  1  2  1  1  1         |    32 1.0|
  INFLAMMATION                              |  1                                                                        |     1 1.0|
  NECROSIS                                  |           1  1  1  1  1  1     1  1  1  1  1     1  1  1  1  1     1      |    34 1.0|
  TENSION LIPOIDOSIS                        |                X  X  X     X  X  X              X           X     X       |    17    |
  VACUOLIZATION CYTOPLASMIC                 |  3  2  3  1     1  1  1           1           1  1        1  1  1  1      |    27 1.2|
MESENTERY                                   |                                                                           |  1       |
  NECROSIS,FAT                              |                                                                           |     1 4.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  FOCAL CELLULAR CHANGE                     |        2                                                                  |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  2        1        2  1        1  1  1           1  1  1  2  1  1      |    31 1.1|
  INFLAMMATION                              |  1                                                                        |     1 1.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |                          3              4                    1            |     4 2.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1     1  2  1  2  2  2     2  1  1  1     1  2  2  1  2     2      |    38 1.3|
STOMACH                                     | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
STOMACH,FORESTOMACH                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  HYPERKERATOSIS                            |                                                              2            |     1 2.0|
STOMACH,GLANDULAR                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  141
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CYST                                      |                       1              1                                    |     2 1.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFLAMMATION                              |                                      2                                    |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +       | 41       |
BLOOD VESSEL,AORTA                          | +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +       | 41       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION,ARTERY                       |                                            2                              |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CYST                                      |                                               3                           |     1 3.0|
  FOCAL CELLULAR CHANGE                     |                          2                                                |     1 2.0|
  HYPERPLASIA,SPINDLE CELL                  |     1  2  2  2  1  2  3  3  2  2  2  1  2  2  2  2  3  3  2     1  2      |    44 1.9|
  VACUOLIZATION CYTOPLASMIC                 |                                3                                          |     1 3.0|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  FOCAL CELLULAR CHANGE                     |                                                                           |     1 2.0|
  VACUOLIZATION CYTOPLASMIC                 |                                                                 2         |     1 2.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                    1      |     2 1.0|
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +       | 44       |
  CYST                                      |                             2                                             |     1 2.0|
  ECTOPIC THYMUS                            |                                                                           |     1    |
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  ECTASIA                                   |                                                                           |     1 1.0|
  HYPERPLASIA,PARS DISTALIS                 |                    2                                   2                  |     4 2.0|
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  CYST,FOLLICLE                             |                       3                                   4               |     2 3.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                   1  1                                    |     4 1.2|
  ULTIMOBRANCHIAL CYST                      |           2  2  2                 2           2                           |    11 2.2|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  142
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

CLITORAL GLAND                              | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +       | 38       |
  ATROPHY                                   |     3  4  3  3  4  3  4  3  4     3  3  3  3     3  3  4  4  4  4  3      |    38 3.3|
  INFLAMMATION                              |                                                                    1      |     1 1.0|
OVARY                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   | X  X  X     X  X  X  X  X  X  X  X  X  X  X     X           X  X  X       |    32    |
  CYST                                      |    X  X  X                             X     X  X  X  X                   |    15    |
  CYST,PERIOVARIAN TISSUE                   |                            X  X  X  X  X  X        X  X     X             |    10    |
  HEMATOCYST                                |                                           X              X                |     4    |
  HYPERPLASIA,ADENOMATOUS                   |                                         3                                 |     1 3.0|
  HYPERPLASIA,TUBULAR                       |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              2            |     2 2.0|
  OVOTESTIS                                 |                                                     2                     |     1 2.0|
UTERUS                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |  3  3                                                                     |     6 2.8|
  DILATATION                                |                                                                    4      |     2 3.0|
  ECTASIA,VEIN                              |                                               4                           |     1 4.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |        2  3  2  2  2  3  3  3  3  3     2  3  3     2  4  3  3  2         |    35 2.6|
  METAPLASIA,SQUAMOUS                       |  2                                                                        |     1 2.0|
  THROMBUS                                  |                                               4                           |     1 4.0|
VAGINA                                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ATROPHY                                   |     2                                                                     |     2 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              1            |     2 1.5|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA                               |        4                                                                  |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA,LYMPHOID,AXILLARY             |                                      4                                    |     1 4.0|
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |  3  4                                                                     |     4 3.0|
  HEMORRHAGE                                |              4                                                            |     1 4.0|
  HYPERPLASIA,LYMPHOID                      |        2                 2                 2                    4         |     7 2.7|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  143
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  ATROPHY                                   |  3  4  3  3                                                               |     6 3.0|
  HYPERPLASIA,LYMPHOID                      |                       2                             2                     |     3 2.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CONGESTION                                |              2                    2  2     3                              |     5 2.2|
  HEMATOPOIETIC CELL PROLIFERATION          |        4                                   3                              |     6 3.0|
  HYPERPLASIA,LYMPHOID                      |                       2  2  2     1        2        3     3               |    16 2.5|
  INFARCT                                   |                                            3                              |     1 3.0|
  NECROSIS                                  |                                                                           |     1 1.0|
THYMUS                                      | M  M  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +       | 36       |
  ATROPHY,CORTEX                            |           2  2           3  4     4  2  3        3  2  3     3     4      |    25 3.0|
  HYPERPLASIA,LYMPHOID,MEDULLA              |           2           2  3           3              1                     |    10 2.1|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  HYPERPLASIA                               |                                   3                                       |     2 2.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                            2                              |     1 2.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  DEGENERATION,CARTILAGE                    |                                            4                              |     1 4.0|
  FIBROUS OSTEODYSTROPHY                    |     1     1        1  2     2     2  1  2        1     2  1               |    22 1.4|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |     1     1  2  2  2  2  1  2     2  1  3  3  1  1  3  3  2  2  3  1      |    35 1.8|
SKELETAL MUSCLE                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  MINERALIZATION,THALAMUS                   |                                                                           |     1 1.0|
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  144
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1  1     1  1  1     2        1  1  1  1     1                 1  1      |    30 1.0|
PERIPHERAL NERVE                            | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  DEMYELINATION                             |                                            1                              |     1 1.0|
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD,THORACIC                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION,AXON                         |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CONGESTION                                |                                                                           |     1 3.0|
  EDEMA                                     |                                                                           |     1 1.0|
  HEMORRHAGE                                |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                      2  1                          2      |     4 1.7|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1  1     1  2  1  1  1  2     1        1  2  1  1  2  1         |    28 1.2|
  INFLAMMATION                              |                          1                 2                 2            |     4 1.5|
  PIGMENTATION,HEMOSIDERIN                  |        4                                                                  |     1 4.0|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CYTOPLASMIC ALTERATION,RESPIRATORY EPITHEL|                                                                           |     1 2.0|
    IUM                                     |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ECTASIA                                   |                       2                                                   |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1              1  1  1        1  1     1  1        1     1  2     1      |    21 1.0|
LACRIMAL GLAND                              | M  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  M  M       | 37       |
  ATROPHY                                   |        3           2     2                          2                     |     5 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              1  1  2  2  2     2                 1  1  1  1  2            |    21 1.2|
ZYMBAL'S GLAND                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +       | 41       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  145
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:25.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 7| 7| 0| 2| 2| 2| 2| 2| 2| 3| 3| 3| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 7| 7| 7|         S  R   R|
                                            | 9| 9| 2| 3| 3| 4| 0| 0| 0| 3| 3| 4| 5| 5| 5| 5| 9| 9| 9| 9| 5| 5| 5|         U  V   I|
CONTRL FS-2YR 19    19                      | 5| 6| 7| 8| 9| 0| 6| 7| 8| 8| 9| 0| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AMYLOID DEPOSITION,GLOMERULUS             |                                                                           |     1 3.0|
  CYST,RENAL TUBULE                         |  1                 1                                                      |     9 1.0|
  GLOMERULOSCLEROSIS                        |                       2                                                   |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1     1  1  1  1  1  3  2     2  1  2  2     1  1  3  1  2  1  2      |    37 1.3|
  NEPHROPATHY                               |                          1                                                |     2 1.0|
  PIGMENTATION,RENAL TUBULE                 |        1                 1                                                |     2 1.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  1  1  1  1  2  1  2  1  1  1  1  1  1  1     1  1  2  1  2  1  1      |    38 1.1|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  146
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:29.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | A                                                           +  M  +  M  + |          |
  HYPERKERATOSIS                            |                                                                    2      |          |
GALLBLADDER                                 | A                                                           +  +  M  +  + |          |
INTESTINE LARGE                             | A                                                           A  +  A  +  + |          |
INTESTINE LARGE,CECUM                       | M                                                           A  +  A  A  + |          |
INTESTINE LARGE,COLON                       | M                                                           A  +  A  +  + |          |
INTESTINE LARGE,RECTUM                      | A                                                           A  +  A  +  + |          |
INTESTINE SMALL                             | M                                                           A  +  A  +  + |          |
INTESTINE SMALL,DUODENUM                    | M                                                           A  +  A  A  + |          |
INTESTINE SMALL,ILEUM                       | M                                                           A  +  A  A  + |          |
INTESTINE SMALL,JEJUNUM                     | M                                                           A  +  A  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |              2                                                            |          |
  BASOPHILIC FOCUS                          |          X                                                                |          |
  EOSINOPHILIC FOCUS                        |       X                                                                   |          |
  FIBROSIS                                  |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                               1                           |          |
  HYPERPLASIA,BILE DUCT                     |                                                                           |          |
  HYPERPLASIA,KUPFFER CELL                  |                                                                          2|          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2  2  1  1  1  1  1  1  1  1     1  1  1  2  1  1     1  1               |          |
  NECROSIS                                  |     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1        1               |          |
  TENSION LIPOIDOSIS                        |       X     X        X     X     X  X        X                            |          |
  VACUOLIZATION CYTOPLASMIC                 |     2        2  1  1  1  1  1  2  1     1     1  1        1     2         |          |
PANCREAS                                    | A                                                           A  +  A  +  A |          |
  ECTASIA,DUCT                              |                                                                           |          |
SALIVARY GLANDS                             | A                                                           +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              1  1  1  1  1|          |
STOMACH                                     | M                                                           A  +  A  +  + |          |
STOMACH,FORESTOMACH                         | M                                                           A  +  A  +  + |          |
  HYPERKERATOSIS                            |                                                                          2|          |
  HYPERPLASIA                               |                                                                 2         |          |
STOMACH,GLANDULAR                           | M                                                           A  +  A  +  + |          |
  MINERALIZATION                            |                                                                           |          |
TONGUE                                      | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  147
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:29.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +                                                           M  M  +  M  + |          |
BLOOD VESSEL,AORTA                          | +                                                           M  M  +  M  + |          |
HEART                                       | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | A                                                           A  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | A                                                           A  +  +  +  + |          |
  HYPERPLASIA,SPINDLE CELL                  |                                                                 2  2  2   |          |
ADRENAL GLAND,MEDULLA                       | A                                                           A  +  M  +  + |          |
ISLETS, PANCREATIC                          | A                                                           A  +  A  +  A |          |
PARATHYROID GLAND                           | A                                                           +  M  +  M  M |          |
PITUITARY GLAND                             | A                                                           M  M  +  M  + |          |
  ANGIECTASIS                               |                                                                           |          |
  HYPERPLASIA,PARS DISTALIS                 |                                                                           |          |
THYROID GLAND                               | A                                                           +  M  +  M  + |          |
  ULTIMOBRANCHIAL CYST                      |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +                                                           +  +  +  +  + |          |
  ATROPHY                                   |                                                                 4  2  4  3|          |
OVARY                                       | A     +  +     +  +  +           +        +  +              +  +  +  +  + |          |
  ATROPHY                                   |                                                             X             |          |
  CYST                                      |       X  X     X     X           X        X                             X |          |
  CYST,PERIOVARIAN TISSUE                   |                   X                          X                            |          |
  HEMATOCYST                                |                                                                           |          |
  INFLAMMATION                              |                                                                           |          |
UTERUS                                      | A     +     +  +  +  +     +  +  +     +     +     +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                              4           4|          |
  DILATATION                                |                                                                           |          |
  FIBROSIS                                  |                       1           1                                       |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |        3     2  3  3  4     3     3     2     2     3  3  3               |          |
  INFLAMMATION                              |                                                                           |          |
VAGINA                                      | A                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  148
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:29.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  ATROPHY                                   |                                                              4           4|          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +                                                           +  +  +  +  + |          |
  HYPERPLASIA                               |                                                              3            |          |
LYMPH NODE                                  | +                                                           +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | A                                                           +  +  +  +  + |          |
  HEMORRHAGE                                |                                                                    2      |          |
  HYPERPLASIA,LYMPHOID                      |                                                              2     2      |          |
LYMPH NODE,MESENTERIC                       | +                                                           A  +  A  +  + |          |
  INFLAMMATION                              |                                                                           |          |
SPLEEN                                      | M        +           +     +                       +        +  +  A  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |                                                                       4   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                             1                                         4   |          |
  HYPERPLASIA,LYMPHOID                      |                                                                       1   |          |
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                       1   |          |
  NECROSIS                                  |                                                                       1   |          |
THYMUS                                      | A                                                           +  +  M  M  + |          |
  ATROPHY,CORTEX                            |                                                              4  4         |          |
  ECTOPIC PARATHYROID GLAND                 |                                                                X          |          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | A                             +                             +  +  +  +  M |          |
  HYPERPLASIA                               |                                4                                          |          |
  METAPLASIA,SQUAMOUS                       |                                4                                          |          |
SKIN                                        | A                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +                                                           +  +  +  +  + |          |
BONE,FEMUR                                  | +                                                           +  +  +  +  + |          |
BONE,STERNUM                                | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  149
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:30.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                                                                           |          |
SKELETAL MUSCLE                             | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +                                                           +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +                                                           +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +                                                           +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |  1                                                                        |          |
PERIPHERAL NERVE                            | +                                                           +  +  +  +  + |          |
SPINAL CORD                                 | +                                                           +  +  +  +  + |          |
SPINAL CORD,THORACIC                        | +                                                           +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | A                                                           +  M  M  M  + |          |
LUNG                                        | A                                      +                    +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1  1      |          |
NOSE                                        | +                                                           +  +  +  +  + |          |
  INFLAMMATION                              |                                                                          2|          |
TRACHEA                                     | A                                                           +  M  +  M  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A                                                           A  +  A  A  A |          |
HARDERIAN GLAND                             | +                                                           +  +  +  +  M |          |
  HYPERPLASIA                               |                                                                    4      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              1            |          |
LACRIMAL GLAND                              | A                                                           +  +  +  M  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1  1     1|          |
ZYMBAL'S GLAND                              | +                                                           +  +  M  +  M |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | A                                                           +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET              |                                                                       3   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  150
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:30.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 5| 6| 6|
                                            | 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 3| 9| 0| 6|
                                            | 4| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 7| 3| 2| 8| 6|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 2| 2| 2| 2| 5| 5| 5| 8| 8| 8| 8| 0| 1| 1| 1| 5| 5| 5| 5| 7| 7| 8| 8| 0|   U  V   I|
10MG   FS-2YR 20    20                      | 8| 0| 1| 2| 3| 1| 2| 3| 0| 1| 2| 3| 9| 0| 1| 2| 2| 3| 4| 5| 2| 4| 4| 5| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

  CYST,RENAL TUBULE                         |                                                                       1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              1  1  1     1|          |
  VACUOLIZATION CYTOPLASMIC,RENAL TUBULE    |                                                                           |          |
URINARY BLADDER                             | A                                                           A  +  A  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                       1  1|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  151
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:31.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +                    +                                                    |  5       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
GALLBLADDER                                 | +                    +                                                    |  6       |
INTESTINE LARGE                             | +                    +                                                    |  5       |
INTESTINE LARGE,CECUM                       | +                    +                                                    |  4       |
INTESTINE LARGE,COLON                       | +                    +                                                    |  5       |
INTESTINE LARGE,RECTUM                      | +                    +                                                    |  5       |
INTESTINE SMALL                             | +                    +                                      +     +       |  7       |
INTESTINE SMALL,DUODENUM                    | +                    +                                      +             |  5       |
INTESTINE SMALL,ILEUM                       | +                    +                                                    |  4       |
INTESTINE SMALL,JEJUNUM                     | +                    +                                      +     +       |  7       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |                                                                           |     1 2.0|
  BASOPHILIC FOCUS                          | X                                                                         |     2    |
  EOSINOPHILIC FOCUS                        |                                                                           |     1    |
  FIBROSIS                                  |                          1                                                |     1 1.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                       1                 1                                 |     3 1.0|
  HYPERPLASIA,BILE DUCT                     |                          1                                                |     1 1.0|
  HYPERPLASIA,KUPFFER CELL                  |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1  3     1  1     1     1  1  1  1     1  1  2  1  1  1     1  1  1      |    36 1.1|
  NECROSIS                                  |  1  1  1  1  1  1  1        1  1  1  1     1  1  1  1  2     1  1  1      |    36 1.0|
  TENSION LIPOIDOSIS                        | X           X  X     X     X  X  X              X  X  X     X  X  X       |    20    |
  VACUOLIZATION CYTOPLASMIC                 |  1  1     1  1  1  1  2  2  2  2  1  1  3  2  2  2  1  2  1  3  1  2      |    36 1.4|
PANCREAS                                    | +                    +                                +                   |  5       |
  ECTASIA,DUCT                              |                                                        4                  |     1 4.0|
SALIVARY GLANDS                             | +                    +                                                    |  7       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     7 1.0|
STOMACH                                     | +                    +                                                    |  5       |
STOMACH,FORESTOMACH                         | +                    +                                                    |  5       |
  HYPERKERATOSIS                            |                                                                           |     1 2.0|
  HYPERPLASIA                               |                                                                           |     1 2.0|
STOMACH,GLANDULAR                           | +                    +                                                    |  5       |
  MINERALIZATION                            |                       1                                                   |     1 1.0|
TONGUE                                      | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  152
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:31.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +                    +                                                    |  5       |
BLOOD VESSEL,AORTA                          | +                    +                                                    |  5       |
HEART                                       | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +                    +                                +                   |  7       |
ADRENAL GLAND,CORTEX                        | +                    +                                                    |  6       |
  HYPERPLASIA,SPINDLE CELL                  |  1                    1                                                   |     5 1.6|
ADRENAL GLAND,MEDULLA                       | +                    +                                +                   |  6       |
ISLETS, PANCREATIC                          | +                    +                                                    |  4       |
PARATHYROID GLAND                           | +                    M                                                    |  3       |
PITUITARY GLAND                             | +                    +                                                    |  4       |
  ANGIECTASIS                               |                       2                                                   |     1 2.0|
  HYPERPLASIA,PARS DISTALIS                 |                       2                                                   |     1 2.0|
THYROID GLAND                               | +                    +                                                    |  5       |
  ULTIMOBRANCHIAL CYST                      |  2                    3                                                   |     2 2.5|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +                    M                                                    |  7       |
  ATROPHY                                   |  3                                                                        |     5 3.2|
OVARY                                       | +  +                 +  +        +  +  +              +        +          | 22       |
  ATROPHY                                   | X                    X                                                    |     3    |
  CYST                                      |    X                             X                                        |     9    |
  CYST,PERIOVARIAN TISSUE                   |                                        X              X        X          |     5    |
  HEMATOCYST                                |                      X                                                    |     1    |
  INFLAMMATION                              |                                      4                                    |     1 4.0|
UTERUS                                      | +  +        +     +  +        +           +        +     +  +  +  +       | 30       |
  ATROPHY                                   |                                                                           |     2 4.0|
  DILATATION                                |                                                     4           4         |     2 4.0|
  FIBROSIS                                  |                                                                           |     2 1.0|
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |  3  2        2     3           3           2              4  3     3      |    21 2.8|
  INFLAMMATION                              |                       4                                                   |     1 4.0|
VAGINA                                      | +                    +                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  153
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:32.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  ATROPHY                                   |                                                                           |     2 4.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +                    +                                                    |  8       |
  HYPERPLASIA                               |                       2                                                   |     2 2.5|
LYMPH NODE                                  | +     +              +  +              +                 +  +             | 13       |
LYMPH NODE,MANDIBULAR                       | +     +              +                                                    |  8       |
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA,LYMPHOID                      |  2                                                                        |     3 2.0|
LYMPH NODE,MESENTERIC                       | +     +              +  +                                +  +             | 10       |
  INFLAMMATION                              |                       2                                                   |     1 2.0|
SPLEEN                                      | +     +              +  +  +        +              +     +  +     +       | 18       |
  ANGIECTASIS                               |  2                                                                        |     1 2.0|
  ATROPHY                                   |                                                                           |     1 4.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     2 2.5|
  HYPERPLASIA,LYMPHOID                      |                       1     3                       3                     |     4 2.0|
  INFILTRATION CELLULAR,HISTIOCYTIC         |                                                                           |     1 1.0|
  NECROSIS                                  |                                                                           |     1 1.0|
THYMUS                                      | +                    M                                                    |  4       |
  ATROPHY,CORTEX                            |  3                                                                        |     3 3.6|
  ECTOPIC PARATHYROID GLAND                 |                                                                           |     1    |
  HYPERPLASIA,LYMPHOID,MEDULLA              |  2                                                                        |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +                    M                                                    |  6       |
  HYPERPLASIA                               |                                                                           |     1 4.0|
  METAPLASIA,SQUAMOUS                       |                                                                           |     1 4.0|
SKIN                                        | +                    +                                                    |  7       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +                    +                                                    |  8       |
BONE,FEMUR                                  | +                    +                                                    |  8       |
BONE,STERNUM                                | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  154
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:32.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |                       2                                                   |     1 2.0|
SKELETAL MUSCLE                             | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +                    +                                                    |  8       |
BRAIN,CEREBELLUM                            | +                    +                                                    |  8       |
BRAIN,CEREBRUM                              | +                    +                                                    |  8       |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                       1                                                   |     2 1.0|
PERIPHERAL NERVE                            | +                    +                                                    |  8       |
SPINAL CORD                                 | +                    +                                                    |  8       |
SPINAL CORD,THORACIC                        | +                    +                                                    |  8       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +                    +                                                    |  4       |
LUNG                                        | +                    +                                                    |  8       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     4 1.0|
NOSE                                        | +                    +                                                    |  8       |
  INFLAMMATION                              |                                                                           |     1 2.0|
TRACHEA                                     | +                    M                                                    |  4       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +                    +                                                    |  3       |
HARDERIAN GLAND                             | +                    +                                                    |  7       |
  HYPERPLASIA                               |                                                                           |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
LACRIMAL GLAND                              | +                    +                                                    |  6       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                                                                        |     4 1.0|
ZYMBAL'S GLAND                              | +                    +                                                    |  6       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +     +              +                                                    |  8       |
  ACCUMULATION HYALINE DROPLET              |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  155
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:32.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 2| 2| 2| 2| 3| 3| 3| 6| 2| 2| 2| 2| 3| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
FEMALE                      CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 7| 7| 7| 7|         S  R   R|
                                            | 3| 3| 3| 3| 5| 6| 6| 8| 9| 0| 0| 0| 3| 5| 5| 5| 8| 8| 8| 6| 6| 6| 6|         U  V   I|
10MG   FS-2YR 20    20                      | 1| 2| 3| 4| 9| 0| 1| 4| 9| 0| 1| 2| 5| 0| 1| 2| 4| 5| 6| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
URINARY SYSTEM

  CYST,RENAL TUBULE                         |  1     3                                                                  |     3 1.6|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     6 1.0|
  VACUOLIZATION CYTOPLASMIC,RENAL TUBULE    |                       2                                                   |     1 2.0|
URINARY BLADDER                             | +                    +                                                    |  5       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  1                    1                                                   |     4 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  156
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:36.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7|
                                            | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0|
                                            | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|   S  R   R|
                                            | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1|   U  V   I|
25MG   FS-2YR 21    21                      | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +                                                     +  +  +  +  + |          |
GALLBLADDER                                 | +  +  +                                                     +  +  +  +  + |          |
INTESTINE LARGE                             | +  +  +                                                     +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  +                                                     +  +  +  A  + |          |
INTESTINE LARGE,COLON                       | +  +  +                                                     +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  +  +                                                     +  +  +  +  + |          |
INTESTINE SMALL                             | +  +  +                                                     +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  +  +                                                     +  +  +  +  A |          |
  INFLAMMATION                              |                                                                       4   |          |
INTESTINE SMALL,ILEUM                       | +  +  +                                                     +  +  +  A  + |          |
INTESTINE SMALL,JEJUNUM                     | +  +  +                                                     +  +  +  A  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |          X                                                                |          |
  CLEAR CELL FOCUS                          |                   X                                                       |          |
  EOSINOPHILIC FOCUS                        |                   X                                                       |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     2        1           1                             1           1  1   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1  3  1  3  1  1  1     1  2  1  1  1  3  1  1  1  1  1     2  1   |          |
  NECROSIS                                  |           1  1  1  1  1     1     1     1     1  1     1  1  1            |          |
  NECROSIS,COAGULATIVE                      |        4                                                                  |          |
  TENSION LIPOIDOSIS                        |                   X                 X        X           X                |          |
  VACUOLIZATION CYTOPLASMIC                 |     1  1           2           2  2  1  2  2  1  1  1  1     1  1  1     2|          |
PANCREAS                                    | +  +  +                                                     +  +  +  +  + |          |
  ATROPHY                                   |                                                                       3   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1  1                                                     1  1        1|          |
SALIVARY GLANDS                             | +  +  +                                                     +  +  +  +  + |          |
  ATROPHY                                   |                                                                 3         |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        2                                                     2        1  1|          |
STOMACH                                     | +  +  +                                                     +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  +                                                     +  +  +  +  + |          |
  HYPERKERATOSIS                            |                                                                    2      |          |
STOMACH,GLANDULAR                           | +  +  +                                                     +  +  +  +  + |          |
  CYST                                      |                                                                          1|          |
TONGUE                                      | +  +  +                                                     +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  157
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:36.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7|
                                            | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0|
                                            | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|   S  R   R|
                                            | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1|   U  V   I|
25MG   FS-2YR 21    21                      | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | M  M  +                                                     +  +  +  +  + |          |
BLOOD VESSEL,AORTA                          | M  M  +                                                     +  +  +  +  + |          |
HEART                                       | +  +  +                                                     +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +                                                     +  +  +  +  + |          |
  ACCESSORY ADRENAL CORTICAL NODULE         |                                                                         X |          |
ADRENAL GLAND,CORTEX                        | +  +  +                                                     +  +  +  +  + |          |
  HYPERPLASIA,SPINDLE CELL                  |  2  1                                                        1  2  1  1  2|          |
ADRENAL GLAND,MEDULLA                       | +  +  +                                                     +  +  +  +  + |          |
ISLETS, PANCREATIC                          | +  +  +                                                     +  +  +  +  + |          |
PARATHYROID GLAND                           | +  M  +                                                     M  +  +  M  M |          |
PITUITARY GLAND                             | +  +  +                                   +                 +  +  M  +  M |          |
  CYST                                      |                                                              1            |          |
THYROID GLAND                               | +  +  +                                                     +  +  +  M  + |          |
  DEPLETION SECRETORY                       |     2                                                                     |          |
  HYPERPLASIA,FOLLICULAR CELL               |                                                                          4|          |
  INFLAMMATION                              |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

CLITORAL GLAND                              | +  M  +                                                     M  +  +  +  + |          |
  ATROPHY                                   |  4     3                                                           4  4  4|          |
OVARY                                       | +  +  +  +  +        +     +  +  +     +           +  +     +  +  +  M  + |          |
  AMYLOID DEPOSITION                        |  3                                                                        |          |
  ATROPHY                                   |    X  X                                                           X     X |          |
  CYST                                      |          X  X        X        X  X                    X        X  X       |          |
  CYST,PERIOVARIAN TISSUE                   |                            X           X           X                      |          |
  HEMORRHAGE                                |  3                                                                        |          |
UTERUS                                      | +  +  +  +  +  +     +  +  +                 +     +     +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  ATROPHY                                   |  3     4                                                           4      |          |
  DILATATION                                |                                                     2                     |          |
  FIBROSIS                                  |                       2                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  158
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:36.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7|
                                            | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0|
                                            | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|   S  R   R|
                                            | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1|   U  V   I|
25MG   FS-2YR 21    21                      | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,CYSTIC,ENDOMETRIUM            |           2  3  4     2  3  3                 2           3  2  2        2|          |
VAGINA                                      | +  +  +                                                     +  +  +  +  + |          |
  AMYLOID DEPOSITION                        |  2                                                                        |          |
  ATROPHY                                   |        3                                                           2      |          |
  DYSPLASIA                                 |  2                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +                                                     +  +  +  +  + |          |
  CONGESTION                                |  2                                                                        |          |
  HYPERPLASIA                               |  3                                                                 4     3|          |
  MYELOFIBROSIS                             |     4                                                                     |          |
LYMPH NODE                                  | +  +  +                 +                                   +  +  +  A  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +                                                     +  +  +  A  + |          |
  ATROPHY                                   |  4                                                                        |          |
  HEMORRHAGE                                |                                                                           |          |
  HYPERPLASIA,LYMPHOID                      |     2                                                                     |          |
  POLYARTERITIS                             |                                                                           |          |
LYMPH NODE,MESENTERIC                       | +  +  +                                                     M  +  +  A  + |          |
  ATROPHY                                   |  4                                                                 4      |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     4                                                                     |          |
  HEMORRHAGE                                |                                                                           |          |
SPLEEN                                      | +  +  +                    +                 +              +  +  +  +  + |          |
  AMYLOID DEPOSITION                        |  1                                                                        |          |
  ATROPHY                                   |  2                                                                 2  2   |          |
  HEMATOPOIETIC CELL PROLIFERATION          |        3                                                        3  4  4   |          |
  HYPERPLASIA,LYMPHOID                      |                                               3              1            |          |
  NECROSIS                                  |                                                                 2         |          |
  POLYARTERITIS                             |                                                                 2         |          |
THYMUS                                      | M  M  +  +              +                                   +  +  M  M  + |          |
  ATROPHY,CORTEX                            |        4                                                     3           3|          |
  HYPERPLASIA,LYMPHOID,MEDULLA              |           2                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  159
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:37.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7|
                                            | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0|
                                            | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|   S  R   R|
                                            | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1|   U  V   I|
25MG   FS-2YR 21    21                      | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  +           +                                         +  +  +  +  + |          |
  LACTATION                                 |  2                                                                        |          |
SKIN                                        | +  +  +                                                     +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +                                                     +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +                                                     +  +  +  +  + |          |
BONE,STERNUM                                | +  +  +                                                     +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY,MULTIFOCAL         |        2                                                        2        1|          |
SKELETAL MUSCLE                             | +  +  +                                                     +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +                                                     +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +                                                     +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +                                                     +  +  +  +  + |          |
  MINERALIZATION,MULTIFOCAL,THALAMUS        |                                                                 1     2   |          |
PERIPHERAL NERVE                            | +  +  +                                                     +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +                                                     +  +  +  M  + |          |
SPINAL CORD,THORACIC                        | +  +  +                                                     +  +  +  M  + |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  M                                                     +  +  +  +  + |          |
LUNG                                        | +  +  +                 +                                   +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     1                                                           1        2|          |
  METAPLASIA,OSSEOUS                        |                                                             X             |          |
NOSE                                        | +  +  +                                                     +  +  +  +  + |          |
TRACHEA                                     | +  +  +                                                     +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  A  A                                                     +  +  +  A  A |          |
  CATARACT                                  |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211601                                                                                      PAGE:  160
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/03/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 15:38:37.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 6| 7|
                                            | 3| 6| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 6| 5| 8| 0|
                                            | 9| 0| 7| 2| 2| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 3| 3| 3| 3| 8| 3| 4| 5| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
FEMALE                      CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|   S  R   R|
                                            | 5| 8| 9| 1| 1| 1| 4| 4| 4| 4| 7| 7| 0| 0| 0| 0| 4| 4| 4| 4| 8| 0| 0| 1| 1|   U  V   I|
25MG   FS-2YR 21    21                      | 6| 4| 1| 2| 3| 4| 0| 1| 2| 3| 1| 2| 0| 1| 2| 3| 1| 2| 3| 4| 1| 6| 9| 5| 9|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

HARDERIAN GLAND                             | +  +  +                                                     +  +  +  +  + |          |
  ATROPHY                                   |                                                                    2      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                        1         |          |
LACRIMAL GLAND                              | +  M  +                                                     +  +  M  +  + |          |
  CYTOPLASMIC ALTERATION                    |                                                                       2   |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                     1  1     1  1|          |
ZYMBAL'S GLAND                              | M  +  +                                                     +  +  M  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTE