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https://ntp.niehs.nih.gov/go/3246

NCTR Study 211701 Pathology Tables

NCTR EXP/TEST:   211701                                                                                      PAGE:    1
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:10.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
                                            | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6|   U  V   I|
CONTROL A 2YR  1     1                      | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
GALLBLADDER                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
  AUTOLYSIS                                 |     4                                                                     |          |
  CRYSTALS,EPITHELIUM                       |                                                                           |          |
INTESTINE LARGE                             | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
INTESTINE LARGE,CECUM                       | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
INTESTINE LARGE,COLON                       | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
INTESTINE LARGE,RECTUM                      | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  GRANULOMA                                 |                                                                           |          |
INTESTINE SMALL                             | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
INTESTINE SMALL,DUODENUM                    | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
INTESTINE SMALL,ILEUM                       | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
INTESTINE SMALL,JEJUNUM                     | A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |     4                                                                    3|          |
  BASOPHILIC FOCUS                          |                               X                                           |          |
  CLEAR CELL FOCUS                          |                                                                           |          |
  CLEAR CELL FOCUS,THREE                    |                                                                      X    |          |
  GRANULOMA,MULTIPLE                        |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                              1  1         |          |
  NECROSIS,HEPATOCYTE                       |                                                                          4|          |
  NECROSIS,MULTIFOCAL,HEPATOCYTE            |                                                                           |          |
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                                                  2                        |          |
PANCREAS                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                       4|          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
  DEGENERATION                              |        3                                                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                          2        3                          3            |          |
STOMACH                                     | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
STOMACH,FORESTOMACH                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |                                                                           |          |
  HYPERKERATOSIS,FOCAL                      |                                                                           |          |
  HYPERPLASIA,SQUAMOUS                      |                                                                           |          |
STOMACH,GLANDULAR                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:    2
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:10.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
                                            | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6|   U  V   I|
CONTROL A 2YR  1     1                      | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  AUTOLYSIS                                 |  3                                                                        |          |
  INFLAMMATION,ACUTE,SUBMUCOSA              |                                                                           |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS,AORTA                           |  3  4                                                                     |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
  CARDIOMYOPATHY                            |                                                                       1   |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
  CYST,UNILATERAL                           |                                              X                            |          |
  CYTOLOGIC ALTERATIONS                     |                                                                           |          |
  CYTOPLASMIC ALTERATION                    |                                            3                              |          |
  HYPERPLASIA                               |                 2              3                                          |          |
  HYPERPLASIA,SPINDLE CELL                  |                          3        3  3  2  3  3  2        2  3            |          |
  HYPERTROPHY                               |                                                                           |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
  CYST                                      |                                                                           |          |
PITUITARY GLAND                             | +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
  CYST                                      |                         X                                      X          |          |
  HYPERPLASIA,FOCAL,PARS DISTALIS           |                                                                           |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:    3
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:11.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
                                            | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6|   U  V   I|
CONTROL A 2YR  1     1                      | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  CYST,FOLLICLE                             |                X  X     X                                                 |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
EPIDIDYMIS                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
  GRANULOMA SPERM                           |                                                                 3         |          |
  INFLAMMATION,CHRONIC                      |                                                                           |          |
PREPUTIAL GLAND                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                         3              2  4        2  3  4|          |
  AUTOLYSIS                                 |  3                                                                        |          |
  CYST                                      |                                                                           |          |
  DILATATION                                |                                                           2               |          |
  INFLAMMATION                              |           4                                                               |          |
  INFLAMMATION,CHRONIC,UNILATERAL           |                                                                           |          |
PROSTATE                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                         3                                 |          |
  AUTOLYSIS                                 |     4                                                                     |          |
SEMINAL VESICLE                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                                                          2|          |
  AUTOLYSIS                                 |  3                                                                        |          |
  DILATATION                                |                                                                       2   |          |
TESTES                                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,UNILATERAL                        |                                                                           |          |
  AUTOLYSIS                                 |  3                                                                       3|          |
  DEGENERATION,BILATERAL                    |                                                           2               |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                    3|          |
  HYPERPLASIA                               |                                                                           |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  GRANULOMA,INGUINAL                        |       X                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:    4
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:11.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
                                            | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6|   U  V   I|
CONTROL A 2YR  1     1                      | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                    3|          |
  DEGENERATION                              |                 3                                                         |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
  HEMORRHAGE                                |                 2                                                         |          |
  HYPERPLASIA                               |                                      3                                    |          |
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                    3|          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                          4|          |
  HYPERPLASIA,LYMPHOID                      |                                      4  2                                 |          |
THYMUS                                      | +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +  +  +  M  M  +  +  M  M  M |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  +  M  M  M  M  M  +  +  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
  GRANULOMA                                 |       X                                                                   |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
  FIBROUS OSTEODYSTROPHY                    |                          3                                                |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
  MINERALIZATION,FOCAL                      |     2                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:    5
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:11.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
                                            | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6|   U  V   I|
CONTROL A 2YR  1     1                      | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
  MINERALIZATION,THALAMUS                   |                 3           2     2  1  2  2  2     2     3  2  2         |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
  DEGENERATION                              |                                                                           |          |
  DEMYELINATION                             |                                3                                          |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                           3               |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
  DILATATION,BRONCHIOLE,GLANDS              |                                      2                                    |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         3                                 |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
  DILATATION,GLANDS                         |                                                                 2         |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |     3                                                                     |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,FOCAL,UNILATERAL                  |                                                           2               |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:    6
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:11.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
                                            | 0| 3| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 5| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 5| 5| 6| 6| 8| 8| 8| 8| 8| 8| 8| 8| 8| 6|   U  V   I|
CONTROL A 2YR  1     1                      | 8| 9| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 3| 4| 5| 6| 7| 8| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  HYPERPLASIA,FOCAL,UNILATERAL              |                                                                           |          |
  HYPERPLASIA,UNILATERAL                    |                                               1                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                2           3                       2  2   |          |
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,FOCAL                             |                                                                           |          |
  AUTOLYSIS                                 |  3  4                                                                     |          |
ZYMBAL'S GLAND                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  4                                                                    3|          |
  CYST,RENAL TUBULE                         |                               X  X     X     X                            |          |
  DEGENERATION,RENAL TUBULE                 |                                2  2              2  2           2         |          |
  GLOMERULOSCLEROSIS                        |                                                                          2|          |
  INFARCT,UNILATERAL                        |                 2                                                         |          |
  INFLAMMATION,CHRONIC                      |                    1                                                      |          |
  MINERALIZATION,RENAL TUBULE               |                          2  1                    2              1         |          |
  NEPHROPATHY                               |                                                                           |          |
  REGENERATION,RENAL TUBULE                 |           1  2     1  2  2     2  2              2  2        2  2         |          |
  VACUOLIZATION CYTOPLASMIC,BILATERAL,RENAL |                                                        3                  |          |
    TUBULE                                  |                                                                           |          |
URINARY BLADDER                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |     4                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                         3                                 |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:    7
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:26.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         U  V   I|
CONTROL A 2YR  1     1                      | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.0|
GALLBLADDER                                 | A  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  AUTOLYSIS                                 |                                      3                                    |     2 3.5|
  CRYSTALS,EPITHELIUM                       |                                                                    3      |     1 3.0|
INTESTINE LARGE                             | A  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +       | 41       |
INTESTINE LARGE,CECUM                       | A  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +       | 41       |
INTESTINE LARGE,COLON                       | A  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +       | 41       |
INTESTINE LARGE,RECTUM                      | A  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +       | 41       |
  GRANULOMA                                 |                                                    X                      |     1    |
INTESTINE SMALL                             | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
INTESTINE SMALL,DUODENUM                    | A  A  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +       | 41       |
INTESTINE SMALL,ILEUM                       | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
INTESTINE SMALL,JEJUNUM                     | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 42       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |     4                                                                     |     3 3.6|
  BASOPHILIC FOCUS                          |                   X                             X                         |     3    |
  CLEAR CELL FOCUS                          |             X                                                             |     1    |
  CLEAR CELL FOCUS,THREE                    |                                                                           |     1    |
  GRANULOMA,MULTIPLE                        |                X                                                          |     1    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.0|
  NECROSIS,HEPATOCYTE                       |                                                                           |     1 4.0|
  NECROSIS,MULTIFOCAL,HEPATOCYTE            |  2                                                                        |     1 2.0|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                                               3                           |     2 2.5|
PANCREAS                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |  4     4                                                                  |     4 3.7|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4  4  3                                                                  |     5 3.6|
  DEGENERATION                              |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        3        3     2  2     3                                3         |     9 2.6|
STOMACH                                     | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
STOMACH,FORESTOMACH                         | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  AUTOLYSIS                                 |                                      4                                    |     1 4.0|
  HYPERKERATOSIS,FOCAL                      |                                                                    2      |     1 2.0|
  HYPERPLASIA,SQUAMOUS                      |                                                                    2      |     1 2.0|
STOMACH,GLANDULAR                           | A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:    8
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:27.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         U  V   I|
CONTROL A 2YR  1     1                      | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  AUTOLYSIS                                 |                                      4                                    |     2 3.5|
  INFLAMMATION,ACUTE,SUBMUCOSA              |                                                                    3      |     1 3.0|
TONGUE                                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS,AORTA                           |  3                                                                        |     3 3.3|
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  3                                                                        |     3 3.3|
  CARDIOMYOPATHY                            |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
ADRENAL GLAND,CORTEX                        | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.2|
  CYST,UNILATERAL                           |                                                                           |     1    |
  CYTOLOGIC ALTERATIONS                     |                                   1                                       |     1 1.0|
  CYTOPLASMIC ALTERATION                    |                             2                                   2  1      |     4 2.0|
  HYPERPLASIA                               |                       2                    3           3     3            |     6 2.6|
  HYPERPLASIA,SPINDLE CELL                  |  3     3  3     3  2        2  2     2  2  3  2  2           2  2  2      |    24 2.4|
  HYPERTROPHY                               |                                         2                       2         |     2 2.0|
ADRENAL GLAND,MEDULLA                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  AUTOLYSIS                                 |        2                                                                  |     3 3.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
PARATHYROID GLAND                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.0|
  CYST                                      |                                        X                                  |     1    |
PITUITARY GLAND                             | +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +       | 42       |
  AUTOLYSIS                                 |  4     2                                                                  |     3 3.0|
  CYST                                      |                                                                           |     2    |
  HYPERPLASIA,FOCAL,PARS DISTALIS           |                                                  3                        |     1 3.0|
THYROID GLAND                               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:    9
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:27.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         U  V   I|
CONTROL A 2YR  1     1                      | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  CYST,FOLLICLE                             |       X  X                                                                |     5    |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |  4     2                                                                  |     3 3.0|
EPIDIDYMIS                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |  4     2                                                                  |     3 3.0|
  GRANULOMA SPERM                           |                                                                           |     1 3.0|
  INFLAMMATION,CHRONIC                      |                       1                                                   |     1 1.0|
PREPUTIAL GLAND                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |           2  3     2  2        2     3  3     2           2               |    15 2.6|
  AUTOLYSIS                                 |  4     2                                                                  |     3 3.0|
  CYST                                      |                                                                X          |     1    |
  DILATATION                                |                                                                           |     1 2.0|
  INFLAMMATION                              |                                                                           |     1 4.0|
  INFLAMMATION,CHRONIC,UNILATERAL           |              3                                                            |     1 3.0|
PROSTATE                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                                                                    2      |     2 2.5|
  AUTOLYSIS                                 |  4     2                                                                  |     3 3.3|
SEMINAL VESICLE                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                                                                           |     1 2.0|
  AUTOLYSIS                                 |  4     2                                                                  |     3 3.0|
  DILATATION                                |                                                                           |     1 2.0|
TESTES                                      | A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  ATROPHY,UNILATERAL                        |                       3                                                   |     1 3.0|
  AUTOLYSIS                                 |        2                                                                  |     3 2.6|
  DEGENERATION,BILATERAL                    |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |                                                                           |     3 3.3|
  HYPERPLASIA                               |                                                                 3         |     1 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  GRANULOMA,INGUINAL                        |                                                                           |     1    |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   10
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:27.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         U  V   I|
CONTROL A 2YR  1     1                      | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4  4  3                                                                  |     4 3.5|
LYMPH NODE,MESENTERIC                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     2                                                                  |     5 3.2|
  DEGENERATION                              |                                                  2     3           1      |     4 2.2|
  HEMATOPOIETIC CELL PROLIFERATION          |                       3                                                   |     1 3.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  HYPERPLASIA                               |                                                                           |     1 3.0|
SPLEEN                                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |        4                                                                  |     4 3.5|
  HEMATOPOIETIC CELL PROLIFERATION          |        3                                                                  |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |                                                                 3         |     3 3.0|
THYMUS                                      | +  M  M  +  +  +  +  M  +  +  +  +  M  +  +  M  +  M  M  M  M  M  +       | 29       |
  AUTOLYSIS                                 |  3                                                                        |     3 3.3|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M       |  5       |
  AUTOLYSIS                                 |                                                                           |     2 3.5|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4     4                                                                  |     4 3.7|
  GRANULOMA                                 |                                                                           |     1    |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
BONE,FEMUR                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |        2                                                                  |     3 3.0|
BONE,STERNUM                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |        2                                                                  |     3 3.0|
  FIBROUS OSTEODYSTROPHY                    |        2        2              1                                          |     4 2.0|
SKELETAL MUSCLE                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.0|
  MINERALIZATION,FOCAL                      |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   11
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:27.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         U  V   I|
CONTROL A 2YR  1     1                      | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
BRAIN,CEREBELLUM                            | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     4                                                                  |     4 3.7|
BRAIN,CEREBRUM                              | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     4                                                                  |     4 3.7|
  MINERALIZATION,THALAMUS                   |           3  1     2  2  2        2  2  2  2        2  2     2  2  2      |    25 2.0|
PERIPHERAL NERVE                            | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.0|
  DEGENERATION                              |                          3  1                                             |     2 2.0|
  DEMYELINATION                             |                                                                           |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 3.0|
SPINAL CORD                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     4                                                                  |     4 3.7|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  A  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  3                                                                        |     3 3.3|
  DILATATION,BRONCHIOLE,GLANDS              |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        3                                               2           1      |     4 2.2|
NOSE                                        | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.2|
TRACHEA                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.0|
  DILATATION,GLANDS                         |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |  4     2                                                                  |     3 3.0|
HARDERIAN GLAND                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY,FOCAL,UNILATERAL                  |                                                                           |     1 2.0|
  AUTOLYSIS                                 |  4     2                                                                  |     4 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   12
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:27.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 8| 7| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 5| 6| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|         U  V   I|
CONTROL A 2YR  1     1                      | 0| 1| 9| 1| 2| 3| 4| 5| 6| 7| 8| 5| 8| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  HYPERPLASIA,FOCAL,UNILATERAL              |                                                  2                        |     1 2.0|
  HYPERPLASIA,UNILATERAL                    |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                                  |     5 2.0|
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M       | 47       |
  ATROPHY,FOCAL                             |                             1                                             |     1 1.0|
  AUTOLYSIS                                 |  4  4  3                                                                  |     5 3.6|
ZYMBAL'S GLAND                              | +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  AUTOLYSIS                                 |  4     2                                                                  |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |  4                                   3                                    |     5 3.4|
  CYST,RENAL TUBULE                         |                         X                                                 |     5    |
  DEGENERATION,RENAL TUBULE                 |                                                                           |     5 2.0|
  GLOMERULOSCLEROSIS                        |                                      2                                    |     2 2.0|
  INFARCT,UNILATERAL                        |                                                           2               |     2 2.0|
  INFLAMMATION,CHRONIC                      |                                                                           |     1 1.0|
  MINERALIZATION,RENAL TUBULE               |                                                                           |     4 1.5|
  NEPHROPATHY                               |                       2                    2  2           2     3  2      |     6 2.1|
  REGENERATION,RENAL TUBULE                 |                                                                           |    11 1.8|
  VACUOLIZATION CYTOPLASMIC,BILATERAL,RENAL |                                                                           |     1 3.0|
    TUBULE                                  |                                                                           |          |
URINARY BLADDER                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |  4     2                                                                  |     3 3.3|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                3           2                       2      |     4 2.5|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   13
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:31.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 3| 5| 7| 3| 2| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 3| 6| 5| 4| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 6| 8| 9| 9| 9| 9| 9| 9| 6|   U  V   I|
25 MG/KGA 2YR  2     2                      | 4| 6| 8| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +                                                        + |          |
GALLBLADDER                                 | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |        3  4  4  4                                                         |          |
INTESTINE LARGE                             | +  +  A  A  A  A                                                        A |          |
INTESTINE LARGE,CECUM                       | +  +  A  A  A  A                                                        A |          |
INTESTINE LARGE,COLON                       | +  +  A  A  A  A                                                        A |          |
INTESTINE LARGE,RECTUM                      | +  +  A  A  A  A                                                        A |          |
INTESTINE SMALL                             | +  +  A  A  +  A           +                                            A |          |
INTESTINE SMALL,DUODENUM                    | +  +  A  A  +  A           +                                            A |          |
  AUTOLYSIS                                 |              3                                                            |          |
INTESTINE SMALL,ILEUM                       | +  +  A  A  A  A                                                        A |          |
INTESTINE SMALL,JEJUNUM                     | +  +  A  A  A  A                                                        A |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |        3  3                                                               |          |
  BASOPHILIC FOCUS                          |                                           X                               |          |
  CLEAR CELL FOCUS                          |                                                                           |          |
  EOSINOPHILIC FOCUS                        |                                                                           |          |
  FATTY CHANGE,FOCAL                        |                                                                           |          |
  HYPERPLASIA,BILE DUCT                     |                                            2                              |          |
  INFARCT                                   |                            X                                         X    |          |
  MIXED CELL FOCUS                          |                                                 X                         |          |
  NECROSIS,HEPATOCYTE                       |                                                                          3|          |
  REGENERATION,FOCAL                        |                                            3                              |          |
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                                         1                                 |          |
PANCREAS                                    | +  +  +  +  +  +                                                        + |          |
  ATROPHY,ACINAR CELL                       |                                                                           |          |
  CYST,DUCT                                 |                                                                           |          |
  FIBROSIS                                  |                                                                           |          |
SALIVARY GLANDS                             | +  +  A  +  +  +                                                        + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
STOMACH                                     | +  +  +  +  +  +                                                        + |          |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +                                                        + |          |
STOMACH,GLANDULAR                           | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |        4  4     4                                                        2|          |
TONGUE                                      | +  +  +  +  +  +                                                        + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   14
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:31.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 3| 5| 7| 3| 2| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 3| 6| 5| 4| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 6| 8| 9| 9| 9| 9| 9| 9| 6|   U  V   I|
25 MG/KGA 2YR  2     2                      | 4| 6| 8| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +                                                        + |          |
HEART                                       | +  +  +  +  +  +                                                        + |          |
  HEMORRHAGE,MYOCARDIUM                     |     3                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +                                                        + |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |        3                                                                  |          |
  CYTOPLASMIC ALTERATION                    |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |  1  1  2  2  3                                                            |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +                                                        + |          |
ISLETS, PANCREATIC                          | +  +  +  +  +  +                                                        + |          |
PARATHYROID GLAND                           | +  +  M  M  +  M                                                        + |          |
PITUITARY GLAND                             | M  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |        4                                                                  |          |
THYROID GLAND                               | +  +  +  +  +  +                                                        + |          |
  CYST,FOLLICLE                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |        4                                                                  |          |
EPIDIDYMIS                                  | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |        4                                                                  |          |
PREPUTIAL GLAND                             | +  +  M  +  +  +                                                        + |          |
  ABSCESS                                   |                                                                           |          |
  ATROPHY                                   |  3  3                                                                     |          |
  ECTASIA,DUCT                              |  3        3                                                               |          |
PROSTATE                                    | +  +  +  +  +  +                                                        + |          |
SEMINAL VESICLE                             | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |        4                                                                  |          |
  DISTENDED                                 |                                                                           |          |
TESTES                                      | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |        4                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   15
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:31.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 3| 5| 7| 3| 2| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 3| 6| 5| 4| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 6| 8| 9| 9| 9| 9| 9| 9| 6|   U  V   I|
25 MG/KGA 2YR  2     2                      | 4| 6| 8| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +                                                        + |          |
  HYPERPLASIA                               |  2                                                                        |          |
LYMPH NODE                                  | +  +  +  +  +  +  +        +  +                    +                    + |          |
LYMPH NODE,MANDIBULAR                       | +  +  A  +  +  +                                                        + |          |
  INFLAMMATION,CHRONIC                      |                                                                           |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +           +  +                    +                    + |          |
  DEGENERATION                              |  2  3     2                                         2                     |          |
SPLEEN                                      | +  +  +  +  +  +  +        +  +           +        +     +              + |          |
  APOPTOSIS,LYMPHOCYTE                      |                                                                          3|          |
  ATROPHY,LYMPHOCYTE                        |     3     2                                                               |          |
  CONGESTION                                |  4                                                                        |          |
  HEMATOPOIETIC CELL PROLIFERATION          |        3           3                                3     3              3|          |
THYMUS                                      | +  M  M  +  +  M           +                                            M |          |
  ECTOPIC PARATHYROID GLAND                 |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  M  M  M  M                                                        M |          |
SKIN                                        | +  +  +  +  +  +                                                        + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +                                                        + |          |
BONE,FEMUR                                  | +  +  +  +  +  +                                                        + |          |
BONE,STERNUM                                | +  +  +  +  +  +                                                        + |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +                                                        + |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +                                                        + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |                 3                                                         |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |                 3                                                         |          |
  MINERALIZATION,THALAMUS                   |  2           2                                                            |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +                                                        + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   16
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:31.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 3| 5| 7| 3| 2| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 3| 6| 5| 4| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 3|   S  R   R|
                                            | 6| 6| 6| 7| 7| 7| 9| 9| 9| 9| 9| 9| 9| 9| 5| 6| 6| 8| 9| 9| 9| 9| 9| 9| 6|   U  V   I|
25 MG/KGA 2YR  2     2                      | 4| 6| 8| 4| 5| 6| 1| 2| 3| 4| 5| 6| 7| 8| 3| 7| 8| 9| 0| 1| 2| 3| 4| 5| 4|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

SPINAL CORD                                 | +  +  +  +  +  +                                                        + |          |
  AUTOLYSIS                                 |                 3                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +                                                        + |          |
LUNG                                        | +  +  +  +  +  +  +     +                                   +           + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |              2                                                            |          |
  INFLAMMATION,CHRONIC ACTIVE               |  3                                                                        |          |
NOSE                                        | +  +  +  +  +  +                                                        + |          |
TRACHEA                                     | +  +  +  +  +  +                                                        + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +                          +                             + |          |
  CATARACT,LENS                             |                                           X                               |          |
HARDERIAN GLAND                             | +  +  +  +  +  +     +  +                 +           +                 + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 2                                                         |          |
LACRIMAL GLAND                              | +  +  A  +  +  +                                                        + |          |
ZYMBAL'S GLAND                              | +  +  +  +  +  M                                                        + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +                                                        + |          |
  ACCUMULATION HYALINE DROPLET,RENAL TUBULE |                                                                           |          |
  AUTOLYSIS                                 |           3                                                               |          |
  GLOMERULOSCLEROSIS                        |        2     3                                                            |          |
  INFARCT,UNILATERAL                        |              2                                                            |          |
  MINERALIZATION,RENAL TUBULE               |           1                                                               |          |
URINARY BLADDER                             | +  +  +  +  +  +                                                        + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   17
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:33.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 4| 7| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 5| 5| 6| 9| 9| 9| 9| 9| 9| 9|         U  V   I|
25 MG/KGA 2YR  2     2                      | 9| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 7| 6| 7| 9| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +                                                                | 11       |
GALLBLADDER                                 | +  +  +  M                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     4 3.7|
INTESTINE LARGE                             | +  +  +  A                                                                |  5       |
INTESTINE LARGE,CECUM                       | +  +  +  A                                                                |  5       |
INTESTINE LARGE,COLON                       | +  +  +  A                                                                |  5       |
INTESTINE LARGE,RECTUM                      | +  +  +  A                                                                |  5       |
INTESTINE SMALL                             | +  +  +  A                                                                |  7       |
INTESTINE SMALL,DUODENUM                    | +  +  +  A                                                                |  7       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
INTESTINE SMALL,ILEUM                       | +  +  +  A                                                                |  5       |
INTESTINE SMALL,JEJUNUM                     | +  +  +  A                                                                |  5       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     2 3.0|
  BASOPHILIC FOCUS                          |             X              X                                              |     3    |
  CLEAR CELL FOCUS                          |                                  X                                        |     1    |
  EOSINOPHILIC FOCUS                        |                         X                                                 |     1    |
  FATTY CHANGE,FOCAL                        |                                                     3                     |     1 3.0|
  HYPERPLASIA,BILE DUCT                     |                                                                           |     1 2.0|
  INFARCT                                   |                                                                           |     2    |
  MIXED CELL FOCUS                          |                                                                           |     1    |
  NECROSIS,HEPATOCYTE                       |                                                                           |     1 3.0|
  REGENERATION,FOCAL                        |                                                                           |     1 3.0|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                                                                           |     1 1.0|
PANCREAS                                    | +  +  +  M                                                                | 10       |
  ATROPHY,ACINAR CELL                       |     4                                                                     |     1 4.0|
  CYST,DUCT                                 |    X                                                                      |     1    |
  FIBROSIS                                  |     4                                                                     |     1 4.0|
SALIVARY GLANDS                             | +  +  +  +                                                                | 10       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |  2        2                                                               |     2 2.0|
STOMACH                                     | +  +  +  A                                                                | 10       |
STOMACH,FORESTOMACH                         | +  +  +  A                                                                | 10       |
STOMACH,GLANDULAR                           | +  +  +  A                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     4 3.5|
TONGUE                                      | +  +  +  A                                                                | 10       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   18
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:33.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 4| 7| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 5| 5| 6| 9| 9| 9| 9| 9| 9| 9|         U  V   I|
25 MG/KGA 2YR  2     2                      | 9| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 7| 6| 7| 9| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +                                                                | 11       |
HEART                                       | +  +  +  +                                                                | 11       |
  HEMORRHAGE,MYOCARDIUM                     |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +                                                                | 11       |
ADRENAL GLAND,CORTEX                        | +  +  +  +                                                                | 11       |
  AUTOLYSIS                                 |           3                                                               |     2 3.0|
  CYTOPLASMIC ALTERATION                    |     2  3                                                                  |     2 2.5|
  HYPERPLASIA,SPINDLE CELL                  |        1  2                                                               |     7 1.7|
ADRENAL GLAND,MEDULLA                       | +  +  +  +                                                                | 11       |
ISLETS, PANCREATIC                          | +  +  +  M                                                                | 10       |
PARATHYROID GLAND                           | +  +  M  M                                                                |  6       |
PITUITARY GLAND                             | +  +  +  +                                                                | 10       |
  AUTOLYSIS                                 |           3                                                               |     2 3.5|
THYROID GLAND                               | +  +  +  +                                                                | 11       |
  CYST,FOLLICLE                             | X                                                                         |     1    |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  +  +  A                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
EPIDIDYMIS                                  | +  +  +  A                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
PREPUTIAL GLAND                             | +  +  +  A     +                                                          | 10       |
  ABSCESS                                   |                X                                                          |     1    |
  ATROPHY                                   |     2  2                                                                  |     4 2.5|
  ECTASIA,DUCT                              |                                                                           |     2 3.0|
PROSTATE                                    | +  +  +  A                                                                | 10       |
SEMINAL VESICLE                             | +  +  +  A                                         +                      | 11       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
  DISTENDED                                 |                                                     3                     |     1 3.0|
TESTES                                      | +  +  +  +                                                                | 11       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   19
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:33.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 4| 7| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 5| 5| 6| 9| 9| 9| 9| 9| 9| 9|         U  V   I|
25 MG/KGA 2YR  2     2                      | 9| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 7| 6| 7| 9| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  A                                                                | 10       |
  HYPERPLASIA                               |        3                                                                  |     2 2.5|
LYMPH NODE                                  | +  +  +  +                                                                | 15       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +                                                                | 10       |
  INFLAMMATION,CHRONIC                      |     2                                                                     |     1 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  A                                                                | 13       |
  DEGENERATION                              |                                                                           |     4 2.2|
SPLEEN                                      | +  +  +  A                                                                | 16       |
  APOPTOSIS,LYMPHOCYTE                      |                                                                           |     1 3.0|
  ATROPHY,LYMPHOCYTE                        |     3                                                                     |     3 2.6|
  CONGESTION                                |                                                                           |     1 4.0|
  HEMATOPOIETIC CELL PROLIFERATION          |  2  3                                                                     |     7 2.8|
THYMUS                                      | M  M  +  M                                                     +          |  6       |
  ECTOPIC PARATHYROID GLAND                 |       X                                                                   |     1    |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  M  M                                                                |  0       |
SKIN                                        | +  +  +  A                                                                | 10       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +                                                                | 11       |
BONE,FEMUR                                  | +  +  +  +                                                                | 11       |
BONE,STERNUM                                | +  +  +  +                                                                | 11       |
SKELETAL MUSCLE                             | +  +  +  A                                                                | 10       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  A                                                                | 10       |
BRAIN,CEREBELLUM                            | +  +  +  A                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
BRAIN,CEREBRUM                              | +  +  +  A                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  MINERALIZATION,THALAMUS                   |                                                                           |     2 2.0|
PERIPHERAL NERVE                            | +  +  +  A                                                                | 10       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   20
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:33.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 1| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 4| 7| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|         S  R   R|
                                            | 6| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 9| 5| 5| 6| 9| 9| 9| 9| 9| 9| 9|         U  V   I|
25 MG/KGA 2YR  2     2                      | 9| 3| 4| 5| 9| 0| 1| 2| 3| 4| 5| 6| 7| 6| 7| 9| 2| 3| 4| 5| 6| 7| 8|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

SPINAL CORD                                 | +  +  +  A                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +                                                                | 11       |
LUNG                                        | +  +  +  +  +              +        +                 +        +  +       | 20       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
  INFLAMMATION,CHRONIC ACTIVE               |                                                                           |     1 3.0|
NOSE                                        | +  +  +  +                                                                | 11       |
TRACHEA                                     | +  +  +  A                                                                | 10       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  A                                                                | 11       |
  CATARACT,LENS                             |                                                                           |     1    |
HARDERIAN GLAND                             | +  +  +  A           +                    +                               | 16       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
LACRIMAL GLAND                              | +  +  +  +                                                                | 10       |
ZYMBAL'S GLAND                              | +  +  +  A                                                                |  9       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  A                                                                | 10       |
  ACCUMULATION HYALINE DROPLET,RENAL TUBULE |     3  4                                                                  |     2 3.5|
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  GLOMERULOSCLEROSIS                        |     2  3                                                                  |     4 2.5|
  INFARCT,UNILATERAL                        |                                                                           |     1 2.0|
  MINERALIZATION,RENAL TUBULE               |                                                                           |     1 1.0|
URINARY BLADDER                             | +  +  +  A                                                                | 10       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   21
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:37.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 5| 5| 8| 2| 2| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 2| 1| 8| 9| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 6| 6| 7| 7| 7| 8| 9| 0| 0| 0| 0| 0| 0| 5| 6| 9| 9| 9| 9| 0| 0| 0| 0| 6|   U  V   I|
50 MG/KGA 2YR  3     3                      | 5| 5| 9| 2| 3| 8| 1| 9| 0| 1| 2| 3| 4| 5| 4| 9| 6| 7| 8| 9| 0| 1| 2| 3| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |                                                                           |          |
GALLBLADDER                                 | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |     4  4  4  4  4                                                        4|          |
  CYST                                      |                   X                                                       |          |
INTESTINE LARGE                             | +  A  A  A  A  A  +                                                     A |          |
INTESTINE LARGE,CECUM                       | +  A  A  A  A  A  +                                                     A |          |
INTESTINE LARGE,COLON                       | +  A  A  A  A  A  +                                                     A |          |
INTESTINE LARGE,RECTUM                      | +  A  A  A  A  A  +                                                     A |          |
INTESTINE SMALL                             | +  A  A  A  A  A  +        +                                            A |          |
INTESTINE SMALL,DUODENUM                    | +  A  A  A  A  A  +                                                     A |          |
INTESTINE SMALL,ILEUM                       | +  A  A  A  A  A  +        +                                            A |          |
INTESTINE SMALL,JEJUNUM                     | +  A  A  A  A  A  +                                                     A |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  CLEAR CELL FOCUS                          |                                              X                            |          |
  CLEAR CELL FOCUS,MULTIPLE                 |                                                                   X       |          |
  CLEAR CELL FOCUS,TWO                      |                                                                           |          |
  CONGESTION                                |  4                                                                        |          |
  EOSINOPHILIC FOCUS                        |                                                                           |          |
  FIBROSIS,FOCAL                            |                                                                           |          |
  GRANULOMA,MULTIPLE                        |                                                                   X       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  NECROSIS,FOCAL,HEPATOCYTE                 |                                                                           |          |
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                                               1                           |          |
MESENTERY                                   |       +                                                                   |          |
PANCREAS                                    | +  +  M  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |           3     4                                                         |          |
SALIVARY GLANDS                             | +  +  +  A  +  +  +                                                     + |          |
STOMACH                                     | +  +  +  +  +  +  +                                                     + |          |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |           4                                                               |          |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |     4  4  4  4                                                           3|          |
TONGUE                                      | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   22
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:38.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 5| 5| 8| 2| 2| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 2| 1| 8| 9| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 6| 6| 7| 7| 7| 8| 9| 0| 0| 0| 0| 0| 0| 5| 6| 9| 9| 9| 9| 0| 0| 0| 0| 6|   U  V   I|
50 MG/KGA 2YR  3     3                      | 5| 5| 9| 2| 3| 8| 1| 9| 0| 1| 2| 3| 4| 5| 4| 9| 6| 7| 8| 9| 0| 1| 2| 3| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +                                                     + |          |
HEART                                       | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |           3                                                               |          |
  CONGESTION                                |  4                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +                                                     + |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |        3                                                                  |          |
  HYPERPLASIA                               |                                                                           |          |
  HYPERPLASIA,SPINDLE CELL                  |           2                                                               |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |        3                                                                  |          |
ISLETS, PANCREATIC                          | +  +  M  +  +  +  +                                                     + |          |
PARATHYROID GLAND                           | M  M  M  +  +  +  M                                                     + |          |
  AUTOLYSIS                                 |                                                                           |          |
PITUITARY GLAND                             | +  +  +  +  +  M  M                                                     + |          |
  AUTOLYSIS                                 |                                                                           |          |
THYROID GLAND                               | +  +  +  +  +  +  M                                                     + |          |
  AUTOLYSIS                                 |                 3                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  +  M  A  +  +  +  +                                                  + |          |
  AUTOLYSIS                                 |                                                                           |          |
  DISTENDED                                 |                       3                                                   |          |
  INFLAMMATION,CHRONIC ACTIVE               |                    3                                                      |          |
EPIDIDYMIS                                  | +  +  +  A  +  +  +                                                  +  + |          |
  AUTOLYSIS                                 |                                                                           |          |
  INFLAMMATION,CHRONIC ACTIVE               |                    3                                                      |          |
PREPUTIAL GLAND                             | +  +  +  M  +  +  +              +              +                       + |          |
  ATROPHY                                   |     4  4     3  4  4                                                     3|          |
  AUTOLYSIS                                 |                                                                           |          |
  CYST                                      |                                  X                                        |          |
  ECTASIA,DUCT                              |     4  4        4  3                             3                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   23
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:38.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 5| 5| 8| 2| 2| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 2| 1| 8| 9| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 6| 6| 7| 7| 7| 8| 9| 0| 0| 0| 0| 0| 0| 5| 6| 9| 9| 9| 9| 0| 0| 0| 0| 6|   U  V   I|
50 MG/KGA 2YR  3     3                      | 5| 5| 9| 2| 3| 8| 1| 9| 0| 1| 2| 3| 4| 5| 4| 9| 6| 7| 8| 9| 0| 1| 2| 3| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

PROSTATE                                    | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |           4                                                               |          |
  CONGESTION                                |  4                                                                        |          |
  ECTASIA,FOCAL                             |                    3                                                      |          |
SEMINAL VESICLE                             | +  +  +  M  +  +  +  +                                                  + |          |
  AUTOLYSIS                                 |                                                                           |          |
  DEPLETION                                 |                                                                           |          |
  DISTENDED                                 |                       3                                                   |          |
  INFLAMMATION,CHRONIC ACTIVE               |                    3                                                      |          |
TESTES                                      | +  +  +  A  +  +  +                                                     + |          |
  AUTOLYSIS                                 |     3                                                                     |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +                                                     + |          |
  HYPERPLASIA                               |        3     2                                                            |          |
LYMPH NODE                                  | +  +  +  +  +  +  +        +     +     +                    +           + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  A  +  +  +                                                     + |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +        +     +     +                    +           + |          |
  ANGIECTASIS,FOCAL                         |              4                                                            |          |
  CONGESTION                                |                                                                          4|          |
  DEGENERATION                              |  2        2  3     3                                         4            |          |
  GRANULOMA                                 |                                                                           |          |
  HYPERPLASIA                               |                                   3                                       |          |
SPLEEN                                      | +  +  +  +  +  A  +  +                 +                 +              + |          |
  ANGIECTASIS,FOCAL                         |                                                           3               |          |
  ATROPHY,LYMPHOCYTE                        |           3                                                               |          |
  AUTOLYSIS                                 |                                                                           |          |
  HEMATOPOIETIC CELL PROLIFERATION          |              3                                                           4|          |
  HYPERPLASIA,LYMPHOID                      |                       3                                                   |          |
THYMUS                                      | +  M  +  M  M  +  M                                                     M |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  M  M  M  M  M                                                     M |          |
SKIN                                        | +  M  +  +  +  +  +                                                     + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   24
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:38.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 5| 5| 8| 2| 2| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 2| 1| 8| 9| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 6| 6| 7| 7| 7| 8| 9| 0| 0| 0| 0| 0| 0| 5| 6| 9| 9| 9| 9| 0| 0| 0| 0| 6|   U  V   I|
50 MG/KGA 2YR  3     3                      | 5| 5| 9| 2| 3| 8| 1| 9| 0| 1| 2| 3| 4| 5| 4| 9| 6| 7| 8| 9| 0| 1| 2| 3| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

  AUTOLYSIS                                 |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +                                                     + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +                                                     + |          |
BONE,STERNUM                                | +  +  +  +  +  +  +                                                     + |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  A  +  +  +                                                     + |          |
BRAIN,CEREBELLUM                            | +  +  +  A  +  +  +                                                     + |          |
BRAIN,CEREBRUM                              | +  +  +  A  +  +  +                                                     + |          |
  MINERALIZATION,THALAMUS                   |                                                                           |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |                                                                           |          |
SPINAL CORD                                 | +  +  +  A  +  +  +                                                     + |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |                                                                           |          |
LUNG                                        | +  +  +  +  +  +  +                             +                 +     + |          |
  ATELECTASIS                               |                                                                           |          |
  AUTOLYSIS                                 |           3                                                               |          |
  CONGESTION                                |  4                                                                        |          |
  HEMORRHAGE,FOCAL,ALVEOLUS                 |                                                                           |          |
NOSE                                        | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   25
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:38.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 5| 5| 8| 2| 2| 4| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 2| 1| 8| 9| 7| 5| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 7|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 6| 6| 7| 7| 7| 8| 9| 0| 0| 0| 0| 0| 0| 5| 6| 9| 9| 9| 9| 0| 0| 0| 0| 6|   U  V   I|
50 MG/KGA 2YR  3     3                      | 5| 5| 9| 2| 3| 8| 1| 9| 0| 1| 2| 3| 4| 5| 4| 9| 6| 7| 8| 9| 0| 1| 2| 3| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |                 4                                                         |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +                             +                       + |          |
  AUTOLYSIS                                 |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 2                                                        2|          |
LACRIMAL GLAND                              | +  +  +  A  +  +  +                                                     + |          |
ZYMBAL'S GLAND                              | +  +  M  +  +  +  M                                                     + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |     2        3  4                                                         |          |
  CONGESTION                                |  4                                                                        |          |
  GLOMERULOSCLEROSIS                        |                                                                           |          |
  HYDRONEPHROSIS                            |           3        4                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  NEPHROPATHY                               |           4                                                               |          |
URINARY BLADDER                             | +  +  +  +  +  +  +                                                     + |          |
  AUTOLYSIS                                 |           4                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   26
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:40.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 2| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 9| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 6| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 9| 0| 0| 0| 0| 0| 0|         U  V   I|
50 MG/KGA 2YR  3     3                      | 7| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
GALLBLADDER                                 | A  A  +  +                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     6 4.0|
  CYST                                      |                                                                           |     1    |
INTESTINE LARGE                             | A  A  +  +                                                                |  4       |
INTESTINE LARGE,CECUM                       | A  A  +  +                                                                |  4       |
INTESTINE LARGE,COLON                       | A  A  +  +                                                                |  4       |
INTESTINE LARGE,RECTUM                      | A  A  +  +                                                                |  4       |
INTESTINE SMALL                             | A  A  +  +                                                                |  5       |
INTESTINE SMALL,DUODENUM                    | A  A  +  +                                                                |  4       |
INTESTINE SMALL,ILEUM                       | A  A  +  +                                                                |  5       |
INTESTINE SMALL,JEJUNUM                     | A  A  +  +                                                                |  4       |
LIVER                                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  BASOPHILIC FOCUS                          |                X                                                          |     1    |
  CLEAR CELL FOCUS                          |                   X                                   X                   |     3    |
  CLEAR CELL FOCUS,MULTIPLE                 |                                                                           |     1    |
  CLEAR CELL FOCUS,TWO                      |                                     X                                     |     1    |
  CONGESTION                                |                                                                           |     1 4.0|
  EOSINOPHILIC FOCUS                        |          X                                                                |     1    |
  FIBROSIS,FOCAL                            |                                      2                                    |     1 2.0|
  GRANULOMA,MULTIPLE                        |                                                                           |     1    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                    1      |     1 1.0|
  NECROSIS,FOCAL,HEPATOCYTE                 |                          1                                                |     1 1.0|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                    2                                                      |     2 1.5|
MESENTERY                                   |                                                                           |  1       |
PANCREAS                                    | A  A  +  +                                                                |  9       |
  AUTOLYSIS                                 |                                                                           |     2 3.5|
SALIVARY GLANDS                             | +  A  +  +                                                                | 10       |
STOMACH                                     | A  A  +  +                                                                | 10       |
STOMACH,FORESTOMACH                         | A  A  +  +                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
STOMACH,GLANDULAR                           | A  A  +  +                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     5 3.8|
TONGUE                                      | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   27
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:40.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 2| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 9| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 6| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 9| 0| 0| 0| 0| 0| 0|         U  V   I|
50 MG/KGA 2YR  3     3                      | 7| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  A  +  +                                                                | 11       |
HEART                                       | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  CONGESTION                                |                                                                           |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | A  A  +  +                                                                | 10       |
ADRENAL GLAND,CORTEX                        | A  A  +  +                                                                | 10       |
  AUTOLYSIS                                 |        2                                                                  |     2 2.5|
  HYPERPLASIA                               |           3                                                               |     1 3.0|
  HYPERPLASIA,SPINDLE CELL                  |        2  3                                                               |     3 2.3|
ADRENAL GLAND,MEDULLA                       | A  A  +  +                                                                | 10       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
ISLETS, PANCREATIC                          | +  +  +  +                                                                | 11       |
PARATHYROID GLAND                           | +  A  M  +                                                                |  6       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
PITUITARY GLAND                             | A  A  +  +                 +                                              |  9       |
  AUTOLYSIS                                 |        2                                                                  |     1 2.0|
THYROID GLAND                               | +  A  +  +                                                                | 10       |
  AUTOLYSIS                                 |  3     3                                                                  |     3 3.0|
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  A  +  +                                                                | 10       |
  AUTOLYSIS                                 |  3     3                                                                  |     2 3.0|
  DISTENDED                                 |                                                                           |     1 3.0|
  INFLAMMATION,CHRONIC ACTIVE               |                                                                           |     1 3.0|
EPIDIDYMIS                                  | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3     3                                                                  |     2 3.0|
  INFLAMMATION,CHRONIC ACTIVE               |                                                                           |     1 3.0|
PREPUTIAL GLAND                             | +  A  A  +                                                                | 11       |
  ATROPHY                                   |                                                                           |     6 3.6|
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
  CYST                                      |                                                                           |     1    |
  ECTASIA,DUCT                              |                                                                           |     5 3.6|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   28
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:40.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 2| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 9| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 6| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 9| 0| 0| 0| 0| 0| 0|         U  V   I|
50 MG/KGA 2YR  3     3                      | 7| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

PROSTATE                                    | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3     3                                                                  |     3 3.3|
  CONGESTION                                |                                                                           |     1 4.0|
  ECTASIA,FOCAL                             |                                                                           |     1 3.0|
SEMINAL VESICLE                             | +  A  +  +                 +           +                       +          | 14       |
  AUTOLYSIS                                 |  3     3                                                                  |     2 3.0|
  DEPLETION                                 |                                         3                                 |     1 3.0|
  DISTENDED                                 |                             4                                   3         |     3 3.3|
  INFLAMMATION,CHRONIC ACTIVE               |                                                                           |     1 3.0|
TESTES                                      | +  A  +  +                                                                | 10       |
  AUTOLYSIS                                 |  3     3                                                                  |     3 3.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | A  A  +  +                                                                | 10       |
  HYPERPLASIA                               |                                                                           |     2 2.5|
LYMPH NODE                                  | A  A  +  +                             +     +           +                | 17       |
LYMPH NODE,MANDIBULAR                       | M  A  +  +                                                                |  9       |
LYMPH NODE,MESENTERIC                       | A  A  +  +                             +     +                            | 16       |
  ANGIECTASIS,FOCAL                         |                                                                           |     1 4.0|
  CONGESTION                                |                                                                           |     1 4.0|
  DEGENERATION                              |                                                                           |     5 2.8|
  GRANULOMA                                 |                                        X                                  |     1    |
  HYPERPLASIA                               |                                                                           |     1 3.0|
SPLEEN                                      | A  +  +  +              +  +     +              +                         | 17       |
  ANGIECTASIS,FOCAL                         |                                                                           |     1 3.0|
  ATROPHY,LYMPHOCYTE                        |                                                                           |     1 3.0|
  AUTOLYSIS                                 |     4  3                                                                  |     2 3.5|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     2 3.5|
  HYPERPLASIA,LYMPHOID                      |                          1  3                                             |     3 2.3|
THYMUS                                      | M  M  M  +                                                                |  4       |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  M  M                                                                |  0       |
SKIN                                        | +  A  +  +                                                                | 10       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   29
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:41.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 2| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 9| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 6| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 9| 0| 0| 0| 0| 0| 0|         U  V   I|
50 MG/KGA 2YR  3     3                      | 7| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
INTEGUMENTARY SYSTEM

  AUTOLYSIS                                 |        3                                                                  |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +                                                                | 12       |
BONE,FEMUR                                  | +  +  +  +                                                                | 12       |
BONE,STERNUM                                | +  +  +  +                                                                | 12       |
SKELETAL MUSCLE                             | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  A  A  +                                                                |  9       |
BRAIN,CEREBELLUM                            | +  A  A  +                                                                |  9       |
BRAIN,CEREBRUM                              | +  A  A  +                                                                |  9       |
  MINERALIZATION,THALAMUS                   |  2                                                                        |     1 2.0|
PERIPHERAL NERVE                            | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
SPINAL CORD                                 | +  A  A  +                                                                |  9       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
LUNG                                        | +  A  +  +  +                                            +  +             | 16       |
  ATELECTASIS                               |                                                              4            |     1 4.0|
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  CONGESTION                                |                                                                           |     1 4.0|
  HEMORRHAGE,FOCAL,ALVEOLUS                 |        2                                                                  |     1 2.0|
NOSE                                        | +  +  +  +                                                                | 12       |
  AUTOLYSIS                                 |        3                                                                  |     1 3.0|
TRACHEA                                     | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   30
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:41.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 2| 3| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 9| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 6| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 7| 7| 9| 0| 0| 0| 0| 0| 0|         U  V   I|
50 MG/KGA 2YR  3     3                      | 7| 6| 7| 0| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

EYE                                         | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3                                                                        |     2 3.5|
HARDERIAN GLAND                             | +  A  +  +                                                                | 12       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 2.0|
LACRIMAL GLAND                              | +  A  +  +                                                                | 10       |
ZYMBAL'S GLAND                              | M  A  M  +                                                                |  7       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | A  A  +  +                                                                | 10       |
  AUTOLYSIS                                 |        3                                                                  |     4 3.0|
  CONGESTION                                |                                                                           |     1 4.0|
  GLOMERULOSCLEROSIS                        |           3                                                               |     1 3.0|
  HYDRONEPHROSIS                            |                                                                           |     2 3.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           2                                                               |     1 2.0|
  NEPHROPATHY                               |                                                                           |     1 4.0|
URINARY BLADDER                             | +  A  +  +                                                                | 11       |
  AUTOLYSIS                                 |  3     2                                                                  |     3 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   31
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:53.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6|   U  V   I|
100MG/KGA 2YR  4     4                      | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  POLYARTERITIS                             |                                                                           |          |
GALLBLADDER                                 | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          4|          |
  FIBROSIS                                  |                                                                    4      |          |
  INFLAMMATION,CHRONIC,SEROSA               |                                                                           |          |
INTESTINE LARGE                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
INTESTINE LARGE,CECUM                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  3                                                                        |          |
  HYPERPLASIA,LYMPHOID                      |                                                        3                  |          |
  POLYARTERITIS                             |                                                                           |          |
INTESTINE LARGE,COLON                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  3                                                                        |          |
  POLYARTERITIS                             |                                                                           |          |
INTESTINE LARGE,RECTUM                      | M  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A |          |
  POLYARTERITIS                             |                                                                           |          |
INTESTINE SMALL                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
INTESTINE SMALL,DUODENUM                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  3                                                                        |          |
INTESTINE SMALL,ILEUM                       | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  3                                                                        |          |
INTESTINE SMALL,JEJUNUM                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  3                                                                        |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          3|          |
  BASOPHILIC FOCUS                          |                      X                                X                   |          |
  CLEAR CELL FOCUS                          |                                     X                                     |          |
  CLEAR CELL FOCUS,TWO                      |                                                                           |          |
  EOSINOPHILIC FOCUS                        |                                                                           |          |
  INFARCT                                   |                                                                   X       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             2        2                                    |          |
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                       1                                                   |          |
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          4|          |
  POLYARTERITIS                             |                                                                           |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   32
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:53.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6|   U  V   I|
100MG/KGA 2YR  4     4                      | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |  3                          2                             1     2  1      |          |
STOMACH                                     | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
STOMACH,FORESTOMACH                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
STOMACH,GLANDULAR                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  INFLAMMATION,CHRONIC,FOCAL                |                                                                           |          |
  POLYARTERITIS                             |                                                                           |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  + |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CARDIOMYOPATHY                            |                                                                           |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          3|          |
  CYST,UNILATERAL                           |                                                                           |          |
  CYTOPLASMIC ALTERATION                    |                                                        2                  |          |
  DEGENERATION,FOCAL,UNILATERAL             |                                                                           |          |
  HYPERPLASIA                               |                          2     3  3  1                                    |          |
  HYPERPLASIA,SPINDLE CELL                  |                 3  2     2     3  2  2  2        2     2     2     2  2   |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          3|          |
  HYPERPLASIA                               |                                      1                                    |          |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  + |          |
PITUITARY GLAND                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          3|          |
  CYST                                      |                                                                   X       |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST,FOLLICLE                             |                   X                                                       |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   33
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:53.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6|   U  V   I|
100MG/KGA 2YR  4     4                      | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |       +                                                                 + |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DISTENDED                                 |                                                                          4|          |
EPIDIDYMIS                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          4|          |
  GRANULOMA SPERM                           |                                                                           |          |
  GRANULOMA,UNILATERAL                      |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  POLYARTERITIS                             |                                                                           |          |
PENIS                                       |                                                                         + |          |
  CONCRETION                                |                                                                          3|          |
  INFLAMMATION,ACUTE                        |                                                                          4|          |
PREPUTIAL GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                             3     2        3     3  2  2  3  4           3|          |
  CYST                                      |                                              X  X                         |          |
  DILATATION                                |                                                                           |          |
  ECTASIA,DUCT                              |                                                                           |          |
  INFLAMMATION,ACUTE,UNILATERAL             |                                                                           |          |
PROSTATE                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                               2                           |          |
  INFLAMMATION,ACUTE                        |                                                                          3|          |
  INFLAMMATION,FOCAL                        |                                                                           |          |
  POLYARTERITIS                             |                                                                           |          |
SEMINAL VESICLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                            2                              |          |
  AUTOLYSIS                                 |                                                                          4|          |
  DILATATION                                |                                                                          4|          |
  INFLAMMATION,CHRONIC                      |     3                                                                     |          |
  POLYARTERITIS,UNILATERAL                  |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   34
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:53.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6|   U  V   I|
100MG/KGA 2YR  4     4                      | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

TESTES                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          4|          |
  HYPERPLASIA,UNILATERAL,INTERSTITIAL CELL  |              2                                                            |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |  3  3                                                                     |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                                 2         |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CONGESTION                                |                       2                                                   |          |
  DEGENERATION                              |                                                                           |          |
  HEMORRHAGE                                |     3                                                                     |          |
  HYPERPLASIA                               |        3              3        3                                          |          |
  POLYARTERITIS,ARTERY                      |                                                                           |          |
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,LYMPHOCYTE                        |     3                                            2                        |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  2                 2                       4     3                        |          |
  HYPERPLASIA,LYMPHOID                      |                                                                 2         |          |
THYMUS                                      | +  +  M  +  +  M  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          3|          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  +  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                                                     2                     |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   35
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:54.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6|   U  V   I|
100MG/KGA 2YR  4     4                      | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 2         |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          4|          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          4|          |
  HYDROCEPHALUS                             |                                                                           |          |
  MINERALIZATION,THALAMUS                   |  2        3           2  2  2  3     2           1     2                  |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION                              |                                                                           |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                          3|          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  + |          |
  POLYARTERITIS                             |                                                                           |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DILATATION,BRONCHIOLE,GLANDS              |                                                                           |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                 2                 1                                       |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |          |
  POLYARTERITIS                             |                                                                           |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  POLYARTERITIS                             |                                                                           |          |
HARDERIAN GLAND                             | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,DIFFUSE,UNILATERAL            |                 3                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   36
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:30:54.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 2| 6| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 0| 2| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 6| 6| 7| 0| 0| 0| 0| 1| 1| 1| 1| 5| 5| 7| 7| 0| 0| 0| 0| 0| 0| 1| 1| 1| 6|   U  V   I|
100MG/KGA 2YR  4     4                      | 2| 7| 1| 6| 7| 8| 9| 0| 1| 2| 3| 6| 7| 0| 1| 4| 5| 6| 7| 8| 9| 0| 1| 2| 5|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  HYPERPLASIA,FOCAL,BILATERAL               |                                                                           |          |
  HYPERPLASIA,FOCAL,UNILATERAL              |                                3                                          |          |
  HYPERPLASIA,PAPILLARY,UNILATERAL          |                                               3                           |          |
  HYPERPLASIA,UNILATERAL                    |                             4                                             |          |
LACRIMAL GLAND                              | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYTOPLASMIC ALTERATION                    |                                                                    1      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             2                             1               |          |
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                                           |          |
  AUTOLYSIS                                 |                                                                          3|          |
  CYST,RENAL TUBULE                         |                                                 X                 X       |          |
  DEGENERATION,RENAL TUBULE                 |                       1                 2                          3      |          |
  GLOMERULOSCLEROSIS                        |  2                                1        2                              |          |
  INFARCT,UNILATERAL                        |                                                           4               |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                        2        2         |          |
  MINERALIZATION,RENAL TUBULE               |           1                             1                                 |          |
  NEPHROPATHY                               |                                                                           |          |
  REGENERATION,RENAL TUBULE                 |           1     2  2  1                 2     1                    3      |          |
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFLAMMATION,ACUTE                        |                                                                          2|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   37
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:05.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|         U  V   I|
100MG/KGA 2YR  4     4                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
GALLBLADDER                                 | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +       | 44       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
  FIBROSIS                                  |                 4                                                         |     2 4.0|
  INFLAMMATION,CHRONIC,SEROSA               |                 3                                                         |     1 3.0|
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 3.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 43       |
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  BASOPHILIC FOCUS                          |                X                             X        X                   |     5    |
  CLEAR CELL FOCUS                          |                                                                X          |     2    |
  CLEAR CELL FOCUS,TWO                      |          X                                                                |     1    |
  EOSINOPHILIC FOCUS                        |             X                                                             |     1    |
  INFARCT                                   |                X                                                          |     2    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 2.0|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |              1                    1                                1      |     4 1.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   38
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:05.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|         U  V   I|
100MG/KGA 2YR  4     4                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 3  1     2        3                 2                     |    10 2.0|
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  INFLAMMATION,CHRONIC,FOCAL                |                                                        3                  |     1 3.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CARDIOMYOPATHY                            |     2                                                                     |     1 2.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +       | 46       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  CYST,UNILATERAL                           |                            X                                              |     1    |
  CYTOPLASMIC ALTERATION                    |  2                 2  2  3                                                |     5 2.2|
  DEGENERATION,FOCAL,UNILATERAL             |                                3                                          |     1 3.0|
  HYPERPLASIA                               |                                                                           |     4 2.2|
  HYPERPLASIA,SPINDLE CELL                  |  2  2     2  3     2  2  3  2        2     3        2     2  1  1  2      |    27 2.1|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  HYPERPLASIA                               |                                                                           |     1 1.0|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
PARATHYROID GLAND                           | +  +  +  M  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +       | 42       |
PITUITARY GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +       | 46       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  CYST                                      |                                                                           |     1    |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CYST,FOLLICLE                             |                      X                                   X                |     3    |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   39
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:06.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|         U  V   I|
100MG/KGA 2YR  4     4                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

  POLYARTERITIS                             |     4                                                                     |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
GENERAL BODY SYSTEM

TISSUE NOS                                  |                                                                           |  2       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DISTENDED                                 |                                                                           |     1 4.0|
EPIDIDYMIS                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
  GRANULOMA SPERM                           |  3  4                                                                     |     2 3.5|
  GRANULOMA,UNILATERAL                      |                                                          X                |     1    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                        3                  |     1 3.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
PENIS                                       |                                                                           |  1       |
  CONCRETION                                |                                                                           |     1 3.0|
  INFLAMMATION,ACUTE                        |                                                                           |     1 4.0|
PREPUTIAL GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |     4     4  1  4  3                 3  2  1  2        2        2  2      |    21 2.6|
  CYST                                      | X                                                                         |     3    |
  DILATATION                                |  3                                                                        |     1 3.0|
  ECTASIA,DUCT                              |                    3                          2                           |     2 2.5|
  INFLAMMATION,ACUTE,UNILATERAL             |  3                                                                        |     1 3.0|
PROSTATE                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |                                            3              2               |     3 2.3|
  INFLAMMATION,ACUTE                        |                                                                           |     1 3.0|
  INFLAMMATION,FOCAL                        |                                                                    3      |     1 3.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
SEMINAL VESICLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |                                         3                                 |     2 2.5|
  AUTOLYSIS                                 |                                                                           |     1 4.0|
  DILATATION                                |                                                                           |     1 4.0|
  INFLAMMATION,CHRONIC                      |                                                                           |     1 3.0|
  POLYARTERITIS,UNILATERAL                  |     4                                                                     |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   40
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:06.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|         U  V   I|
100MG/KGA 2YR  4     4                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

TESTES                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
  HYPERPLASIA,UNILATERAL,INTERSTITIAL CELL  |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA                               |     3                                      2                              |     4 2.7|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +       | 45       |
  HYPERPLASIA                               |                                                                           |     1 2.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CONGESTION                                |                                                                           |     1 2.0|
  DEGENERATION                              |                                            3  2     2  3  2               |     5 2.4|
  HEMORRHAGE                                |                                                                           |     1 3.0|
  HYPERPLASIA                               |  3                                                                        |     4 3.0|
  POLYARTERITIS,ARTERY                      |     4                                                                     |     1 4.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY,LYMPHOCYTE                        |                                                                           |     2 2.5|
  HEMATOPOIETIC CELL PROLIFERATION          |     4                                      4           3                  |     7 3.1|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
THYMUS                                      | +  M  +  M  +  +  +  M  +  M  +  M  +  +  M  +  +  +  M  +  +  M  +       | 35       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M       |  2       |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FIBROUS OSTEODYSTROPHY                    |                       2                                                   |     2 2.0|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   41
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:06.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|         U  V   I|
100MG/KGA 2YR  4     4                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
MUSCULOSKELETAL SYSTEM

SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
  POLYARTERITIS                             |     4                                                  1                  |     2 2.5|
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
  HYDROCEPHALUS                             |  3                                                                        |     1 3.0|
  MINERALIZATION,THALAMUS                   |     3              2           3                       2        1         |    14 2.1|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION                              |                                                        1                  |     1 1.0|
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DILATATION,BRONCHIOLE,GLANDS              |     4                                                                     |     1 4.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |     2 1.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     3                                                                     |     2 2.5|
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  POLYARTERITIS                             |     4                                                                     |     1 4.0|
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  HYPERPLASIA,DIFFUSE,UNILATERAL            |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   42
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:06.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 5| 7| 7| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|         U  V   I|
100MG/KGA 2YR  4     4                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  HYPERPLASIA,FOCAL,BILATERAL               |                                         3                                 |     1 3.0|
  HYPERPLASIA,FOCAL,UNILATERAL              |                                                                           |     1 3.0|
  HYPERPLASIA,PAPILLARY,UNILATERAL          |                                                                           |     1 3.0|
  HYPERPLASIA,UNILATERAL                    |                                                                           |     1 4.0|
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  CYTOPLASMIC ALTERATION                    |                                                                           |     1 1.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.5|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ANGIECTASIS                               |     4                                                                     |     1 4.0|
  AUTOLYSIS                                 |                                                                           |     1 3.0|
  CYST,RENAL TUBULE                         |                                              X                            |     3    |
  DEGENERATION,RENAL TUBULE                 |                                                                           |     3 2.0|
  GLOMERULOSCLEROSIS                        |     3  2  2     3        2  1              2                              |    10 2.0|
  INFARCT,UNILATERAL                        |                                                                           |     1 4.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                        2                  |     3 2.0|
  MINERALIZATION,RENAL TUBULE               |                                                                 1         |     3 1.0|
  NEPHROPATHY                               |                    1              2                                1      |     3 1.3|
  REGENERATION,RENAL TUBULE                 |                                                                           |     7 1.7|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFLAMMATION,ACUTE                        |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   43
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:06.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3|                                          S  R   R|
                                            | 0| 1| 1| 3| 3| 3| 1| 1| 1| 3| 3| 3|                                          U  V   I|
CONTROL A 64WK 5     5                      | 9| 0| 1| 4| 5| 6| 1| 2| 3| 5| 6| 7|                                          E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +                                        | 12       |
  FATTY CHANGE,FOCAL,PERIPHERAL             |        1           1                                                      |     2 1.0|
  GRANULOMA,MULTIPLE                        |                   X  X     X                                              |     3    |
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |  2  2  2  2     1  2  2  2  2                                             |     9 1.8|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   44
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:07.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3|                                          S  R   R|
                                            | 1| 1| 1| 3| 3| 3| 1| 1| 1| 3| 3| 4|                                          U  V   I|
25MG/KG A 64W 6      6                      | 2| 3| 4| 7| 8| 9| 4| 5| 6| 8| 9| 0|                                          E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +                                        | 12       |
  FATTY CHANGE,FOCAL,PERIPHERAL             |     1  2  3        1        3  2  3                                       |     7 2.1|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |     1           2  2        2  2  3                                       |     6 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   45
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:07.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3|                                          S  R   R|
                                            | 1| 1| 1| 4| 4| 4| 1| 1| 1| 4| 4| 4|                                          U  V   I|
50 MG/KGA 64W  7     7                      | 5| 6| 7| 0| 1| 2| 7| 8| 9| 1| 2| 3|                                          E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +                                        | 12       |
  FATTY CHANGE,PERIPHERAL                   |  3  1     1     1  3     3  2                                             |     7 2.0|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |  2           3     1  1     1  1  1                                       |     7 1.4|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   46
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:07.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3|                                          S  R   R|
                                            | 1| 1| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4|                                          U  V   I|
100MG/KGA 64W  8     8                      | 8| 9| 0| 3| 4| 5| 0| 1| 2| 4| 5| 6|                                          E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +                                        | 12       |
  FATTY CHANGE,PERIPHERAL                   |        2     3     1  1  2     1  1                                       |     7 1.5|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |              2     1     2        2                                       |     4 1.7|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   47
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:16.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
                                            | 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 5| 5| 7| 7| 1| 1| 1| 1| 1| 1| 1| 2| 2| 0|   U  V   I|
CONTROL R 2YR 10    10                      | 0| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 2| 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
GALLBLADDER                                 | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,COLON                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,RECTUM                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,DUODENUM                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE SMALL,JEJUNUM                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CLEAR CELL FOCUS                          |                                                                           |          |
  INFARCT                                   |    X                                                                      |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |        1                                                                  |          |
  MIXED CELL FOCUS                          |                                                          X                |          |
  NECROSIS,HEPATOCYTE                       |  3                                                                        |          |
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,ACINAR CELL                       |  3                                                                       3|          |
  CYST,DUCT                                 |       X                                                                   |          |
  DILATATION,DUCT                           |        3                                                                  |          |
  HYPERPLASIA,LYMPHOID                      |              3                                                            |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     3                                                        2  2         |          |
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYST                                      |                                                                      X    |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ARTERIOSCLEROSIS,ARTERY                   |                                                  2                       2|          |
  MINERALIZATION,AORTA                      |        1                                                                  |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CARDIOMYOPATHY                            |  2        1                                                               |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   48
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:16.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
                                            | 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 5| 5| 7| 7| 1| 1| 1| 1| 1| 1| 1| 2| 2| 0|   U  V   I|
CONTROL R 2YR 10    10                      | 0| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 2| 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  CYTOPLASMIC ALTERATION                    |                             2                                             |          |
  HYPERPLASIA                               |              3           2           3        2                           |          |
  HYPERPLASIA,SPINDLE CELL                  |     2           2  2        2  2  2  3  2     2  1  2     2  3  3         |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  M |          |
PITUITARY GLAND                             | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  + |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
  CYST,FOLLICLE                             | X                    X                                                    |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
EPIDIDYMIS                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PREPUTIAL GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                                            2     2        1  3        3  2|          |
  ECTASIA,DUCT                              |                                                                           |          |
PROSTATE                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M |          |
SEMINAL VESICLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
TESTES                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  DEGENERATION,UNILATERAL,SEMINIFEROUS TUBUL|                                                                           |          |
    E                                       |                                                                           |          |
  MINERALIZATION,UNILATERAL,SEMINIFEROUS TUB|                                                                           |          |
    ULE                                     |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA                               |                                                                           |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ANGIECTASIS                               |                                                  3                        |          |
LYMPH NODE,MESENTERIC                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |        1                                                                  |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   49
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:16.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
                                            | 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 5| 5| 7| 7| 1| 1| 1| 1| 1| 1| 1| 2| 2| 0|   U  V   I|
CONTROL R 2YR 10    10                      | 0| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 2| 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  DEGENERATION                              |                                                                           |          |
  HYPERPLASIA                               |                       3        3                                          |          |
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,LYMPHOCYTE                        |  3                                                                        |          |
  HEMATOPOIETIC CELL PROLIFERATION          |  3     2                                                                  |          |
  HYPERPLASIA,LYMPHOID                      |                          3                          2                     |          |
THYMUS                                      | +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  M  M |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  FIBROUS OSTEODYSTROPHY                    |                                   2                                2      |          |
  OSTEOPETROSIS                             |  3                                                                        |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC,LATERAL |                                                                           |          |
    VENTRICLE                               |                                                                           |          |
  MINERALIZATION,THALAMUS                   |  2              1  3        1  2     2  2     2     2  2     1            |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   50
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:16.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|
                                            | 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 9|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 8| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 5| 5| 7| 7| 1| 1| 1| 1| 1| 1| 1| 2| 2| 0|   U  V   I|
CONTROL R 2YR 10    10                      | 0| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 8| 2| 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 8|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATELECTASIS                               |                                                                           |          |
  GRANULOMA,FOCAL                           |                                              X                            |          |
  HEMORRHAGE                                |           1                                                               |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |     2                                               2                     |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  HYPERPLASIA,UNILATERAL                    |                                      1                                    |          |
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                 1         |          |
ZYMBAL'S GLAND                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET,RENAL TUBULE |  2                                                                        |          |
  CYST,RENAL TUBULE                         |                                                                X          |          |
  DEGENERATION,RENAL TUBULE                 |                                                  2                        |          |
  GLOMERULOSCLEROSIS                        |                                                                    2      |          |
  HYPERPLASIA,FOCAL,UNILATERAL,RENAL TUBULE |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                     2                     |          |
  MINERALIZATION,RENAL TUBULE               |                                                        2                  |          |
  NEPHROPATHY                               |                                                              1            |          |
  REGENERATION,RENAL TUBULE                 |              1                                   3                        |          |
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                  2                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   51
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:23.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 1| 1| 2| 2| 2| 2| 2| 2| 2| 6| 6| 7| 7| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
CONTROL R 2YR 10    10                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
GALLBLADDER                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
INTESTINE LARGE                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
INTESTINE LARGE,CECUM                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
INTESTINE LARGE,COLON                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
INTESTINE LARGE,RECTUM                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
INTESTINE SMALL                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
INTESTINE SMALL,DUODENUM                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
INTESTINE SMALL,ILEUM                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
INTESTINE SMALL,JEJUNUM                     | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CLEAR CELL FOCUS                          |                                        X                                  |     1    |
  INFARCT                                   |                                                                           |     1    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
  MIXED CELL FOCUS                          |                                                                           |     1    |
  NECROSIS,HEPATOCYTE                       |                                                                           |     1 3.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY,ACINAR CELL                       |                                                                           |     2 3.0|
  CYST,DUCT                                 |                                                                           |     1    |
  DILATATION,DUCT                           |                                                                           |     1 3.0|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 3.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                 3                                                  2      |     5 2.4|
STOMACH                                     | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
STOMACH,FORESTOMACH                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
STOMACH,GLANDULAR                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CYST                                      |                                                                           |     1    |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ARTERIOSCLEROSIS,ARTERY                   |                                                                           |     2 2.0|
  MINERALIZATION,AORTA                      |                                                                           |     1 1.0|
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  CARDIOMYOPATHY                            |                    1                                                      |     3 1.3|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   52
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:23.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 1| 1| 2| 2| 2| 2| 2| 2| 2| 6| 6| 7| 7| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
CONTROL R 2YR 10    10                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ENDOCRINE SYSTEM

ADRENAL GLAND                               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +       | 45       |
ADRENAL GLAND,CORTEX                        | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +       | 45       |
  CYTOPLASMIC ALTERATION                    |                                                                           |     1 2.0|
  HYPERPLASIA                               |                                                                           |     4 2.5|
  HYPERPLASIA,SPINDLE CELL                  |     3  2  2  2  1     2     2  2  1  2  1  2  3  2     2  2  2  2  2      |    33 2.0|
ADRENAL GLAND,MEDULLA                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +       | 45       |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
PITUITARY GLAND                             | A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +       | 43       |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  CYST,FOLLICLE                             | X                                                                         |     3    |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
EPIDIDYMIS                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
PREPUTIAL GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |     3        1     2  2                          4        2     2         |    13 2.2|
  ECTASIA,DUCT                              |                                                  4                        |     1 4.0|
PROSTATE                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
SEMINAL VESICLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
TESTES                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  DEGENERATION,UNILATERAL,SEMINIFEROUS TUBUL|                             2                                             |     1 2.0|
    E                                       |                                                                           |          |
  MINERALIZATION,UNILATERAL,SEMINIFEROUS TUB|                             2                                             |     1 2.0|
    ULE                                     |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA                               |  3                                                                        |     1 3.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ANGIECTASIS                               |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  ATROPHY                                   |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   53
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:23.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 1| 1| 2| 2| 2| 2| 2| 2| 2| 6| 6| 7| 7| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
CONTROL R 2YR 10    10                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  DEGENERATION                              |                                            2        3  3     3            |     4 2.7|
  HYPERPLASIA                               |                                                                           |     2 3.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY,LYMPHOCYTE                        |                                                                           |     1 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |     2 2.5|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     2 2.5|
THYMUS                                      | M  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +       | 39       |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M       |  0       |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  FIBROUS OSTEODYSTROPHY                    |                                                                           |     2 2.0|
  OSTEOPETROSIS                             |                                                                           |     1 3.0|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC,LATERAL |                                      1                                    |     1 1.0|
    VENTRICLE                               |                                                                           |          |
  MINERALIZATION,THALAMUS                   |        2     2  1  2                          3     3  2     2            |    19 1.9|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   54
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:23.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 1| 1| 2| 2| 2| 2| 2| 2| 2| 6| 6| 7| 7| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|         U  V   I|
CONTROL R 2YR 10    10                      | 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATELECTASIS                               |                       3                                                   |     1 3.0|
  GRANULOMA,FOCAL                           |                                                                           |     1    |
  HEMORRHAGE                                |                                                                           |     1 1.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                    2                                                      |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                               3                           |     3 2.3|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  HYPERPLASIA,UNILATERAL                    |                                                                           |     1 1.0|
LACRIMAL GLAND                              | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 1.0|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ACCUMULATION HYALINE DROPLET,RENAL TUBULE |                                                                           |     1 2.0|
  CYST,RENAL TUBULE                         |                                                                           |     1    |
  DEGENERATION,RENAL TUBULE                 |                                                                           |     1 2.0|
  GLOMERULOSCLEROSIS                        |                       1                                                   |     2 1.5|
  HYPERPLASIA,FOCAL,UNILATERAL,RENAL TUBULE |                       2                                                   |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
  MINERALIZATION,RENAL TUBULE               |                                                                           |     1 2.0|
  NEPHROPATHY                               |                                                                           |     1 1.0|
  REGENERATION,RENAL TUBULE                 |                                                                           |     2 2.0|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   55
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:25.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|
                                            | 4| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 6| 2| 2| 2| 2| 2| 2| 3| 3| 3| 5| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 6|   U  V   I|
25MG/KG R 2YR 11    11                      | 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +                                                                    + |          |
GALLBLADDER                                 | +  +                                                                    + |          |
INTESTINE LARGE                             | +  +                                                                    + |          |
INTESTINE LARGE,CECUM                       | +  +                                                                    + |          |
  AUTOLYSIS                                 |     4                                                                     |          |
INTESTINE LARGE,COLON                       | +  +                                                                    + |          |
  AUTOLYSIS                                 |     3                                                                     |          |
INTESTINE LARGE,RECTUM                      | +  +                                                                    + |          |
  AUTOLYSIS                                 |     3                                                                     |          |
INTESTINE SMALL                             | +  +                                                           +        + |          |
INTESTINE SMALL,DUODENUM                    | +  +                                                                    + |          |
  AUTOLYSIS                                 |     4                                                                     |          |
  ULCER                                     |                                                                           |          |
INTESTINE SMALL,ILEUM                       | +  +                                                                    + |          |
  AUTOLYSIS                                 |     3                                                                     |          |
INTESTINE SMALL,JEJUNUM                     | +  +                                                           +        + |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  CLEAR CELL FOCUS                          |                                                                           |          |
  EOSINOPHILIC FOCUS                        |                                        X                                  |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                             1                                            1|          |
  NECROSIS,HEPATOCYTE,MIDZONAL              |                                                                           |          |
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                                                                           |          |
PANCREAS                                    | +  +                                                                    + |          |
SALIVARY GLANDS                             | +  +                                                                    + |          |
STOMACH                                     | +  +                                                                    + |          |
STOMACH,FORESTOMACH                         | +  +                                                                    + |          |
  HYPERPLASIA,FOCAL                         |                                                                           |          |
  METAPLASIA,SQUAMOUS                       |                                                                           |          |
STOMACH,GLANDULAR                           | +  +                                                                    + |          |
  AUTOLYSIS                                 |     3                                                                     |          |
TONGUE                                      | +  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   56
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:25.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|
                                            | 4| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 6| 2| 2| 2| 2| 2| 2| 3| 3| 3| 5| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 6|   U  V   I|
25MG/KG R 2YR 11    11                      | 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +                                                                    + |          |
HEART                                       | +  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +                                                                    + |          |
ADRENAL GLAND,CORTEX                        | +  +                                                                    + |          |
ADRENAL GLAND,MEDULLA                       | +  +                                                                    + |          |
ISLETS, PANCREATIC                          | +  +                                                                    + |          |
PARATHYROID GLAND                           | +  +                                                                    + |          |
PITUITARY GLAND                             | +  M                                                                    + |          |
THYROID GLAND                               | +  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +  +                                                                    + |          |
  AUTOLYSIS                                 |                                                                           |          |
EPIDIDYMIS                                  | +  +                                                                    + |          |
  AUTOLYSIS                                 |                                                                           |          |
PREPUTIAL GLAND                             | +  +                                                                    + |          |
  ATROPHY                                   |     4                                                                    3|          |
  AUTOLYSIS                                 |                                                                           |          |
  ECTASIA,DUCT                              |     3                                                                     |          |
PROSTATE                                    | +  +                                                                    + |          |
SEMINAL VESICLE                             | +  +                                                                    + |          |
  AUTOLYSIS                                 |                                                                           |          |
TESTES                                      | +  +                                                                    + |          |
  AUTOLYSIS                                 |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +                                                                    + |          |
  HYPERPLASIA                               |     2                                                                     |          |
LYMPH NODE                                  | +  +                 +                                         +        + |          |
LYMPH NODE,MANDIBULAR                       | +  M                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   57
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:25.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|
                                            | 4| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 6| 2| 2| 2| 2| 2| 2| 3| 3| 3| 5| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 6|   U  V   I|
25MG/KG R 2YR 11    11                      | 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  APOPTOSIS,LYMPHOCYTE                      |  3                                                                        |          |
LYMPH NODE,MESENTERIC                       | +  +                 +                                         +        + |          |
  APOPTOSIS,LYMPHOCYTE                      |  4                                                                        |          |
  DEGENERATION                              |                                                                           |          |
SPLEEN                                      | +  +                                                           +        M |          |
  APOPTOSIS,LYMPHOCYTE                      |  4                                                                        |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                 3         |          |
THYMUS                                      | M  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M                                                                    M |          |
SKIN                                        | +  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +                                                                    + |          |
BONE,FEMUR                                  | +  +                                                                    + |          |
BONE,STERNUM                                | +  +                                                                    + |          |
SKELETAL MUSCLE                             | +  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +  +                                                                    + |          |
BRAIN,CEREBELLUM                            | +  +                                                                    + |          |
BRAIN,CEREBRUM                              | +  +                                                                    + |          |
  HYDROCEPHALUS                             |  2                                                                        |          |
  MINERALIZATION,THALAMUS                   |     2                                                                     |          |
PERIPHERAL NERVE                            | +  +                                                                    + |          |
SPINAL CORD                                 | M  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +                                                                    + |          |
LUNG                                        | +  +                                               +                    + |          |
NOSE                                        | +  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   58
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:25.6
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 1| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 8| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1|
                                            | 4| 4| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 6| 2| 2| 2| 2| 2| 2| 3| 3| 3| 5| 6| 7| 7| 2| 2| 2| 2| 2| 2| 2| 2| 3| 6|   U  V   I|
25MG/KG R 2YR 11    11                      | 3| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 9| 0| 4| 5| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

TRACHEA                                     | +  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EAR                                         |                         +                                                 |          |
EYE                                         | +  +                                                                    + |          |
HARDERIAN GLAND                             | +  +                                   +                                + |          |
LACRIMAL GLAND                              | +  +                                                                    + |          |
ZYMBAL'S GLAND                              | +  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +                                                                    + |          |
  INFARCT,UNILATERAL                        |  3                                                                        |          |
URINARY BLADDER                             | +  +                                                                    + |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   59
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:26.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| 6| 6| 7| 7| 2| 2| 2| 3| 3| 3| 3| 3| 3|         U  V   I|
25MG/KG R 2YR 11    11                      | 2| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 6| 7| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +                                                                         |  4       |
GALLBLADDER                                 | +                                                                         |  4       |
INTESTINE LARGE                             | +                                                                         |  4       |
INTESTINE LARGE,CECUM                       | +                                                                         |  4       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
INTESTINE LARGE,COLON                       | +                                                                         |  4       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
INTESTINE LARGE,RECTUM                      | +                                                                         |  4       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
INTESTINE SMALL                             | +                                                                         |  5       |
INTESTINE SMALL,DUODENUM                    | +                                                                         |  4       |
  AUTOLYSIS                                 |                                                                           |     1 4.0|
  ULCER                                     |  4                                                                        |     1 4.0|
INTESTINE SMALL,ILEUM                       | +                                                                         |  4       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
INTESTINE SMALL,JEJUNUM                     | +                                                                         |  5       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                                                                X          |     1    |
  CLEAR CELL FOCUS                          |                   X                                                       |     1    |
  EOSINOPHILIC FOCUS                        |                                                    X                      |     2    |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 1.0|
  NECROSIS,HEPATOCYTE,MIDZONAL              |  4                                                                        |     1 4.0|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |  3                                                                        |     1 3.0|
PANCREAS                                    | +                                                                         |  4       |
SALIVARY GLANDS                             | +                                                                         |  4       |
STOMACH                                     | +                                               +                         |  5       |
STOMACH,FORESTOMACH                         | +                                               +                         |  5       |
  HYPERPLASIA,FOCAL                         |                                                  1                        |     1 1.0|
  METAPLASIA,SQUAMOUS                       |  2                                                                        |     1 2.0|
STOMACH,GLANDULAR                           | +                                               +                         |  5       |
  AUTOLYSIS                                 |                                                                           |     1 3.0|
TONGUE                                      | +                                                                         |  4       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   60
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:26.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| 6| 6| 7| 7| 2| 2| 2| 3| 3| 3| 3| 3| 3|         U  V   I|
25MG/KG R 2YR 11    11                      | 2| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 6| 7| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +                                                                         |  4       |
HEART                                       | +                                                                         |  4       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +                                                                         |  4       |
ADRENAL GLAND,CORTEX                        | +                                                                         |  4       |
ADRENAL GLAND,MEDULLA                       | +                                                                         |  4       |
ISLETS, PANCREATIC                          | +                                                                         |  4       |
PARATHYROID GLAND                           | M                                                                         |  3       |
PITUITARY GLAND                             | M                                      +                                  |  3       |
THYROID GLAND                               | +                                                                         |  4       |
------------------------------------------------------------------------------------------------------------------------------------
GENITAL SYSTEM

COAGULATING GLAND                           | +                                                                         |  4       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
EPIDIDYMIS                                  | +                                                                         |  4       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
PREPUTIAL GLAND                             | +                                                                         |  4       |
  ATROPHY                                   |                                                                           |     2 3.5|
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
  ECTASIA,DUCT                              |                                                                           |     1 3.0|
PROSTATE                                    | +                                                                         |  4       |
SEMINAL VESICLE                             | +                                                                         |  4       |
  AUTOLYSIS                                 |  3                                                                        |     1 3.0|
TESTES                                      | +                                                                         |  4       |
  AUTOLYSIS                                 |  4                                                                        |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +                                                                         |  4       |
  HYPERPLASIA                               |  3                                                                        |     2 2.5|
LYMPH NODE                                  | +                                      +     +                            |  8       |
LYMPH NODE,MANDIBULAR                       | +                                                                         |  3       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   61
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:26.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| 6| 6| 7| 7| 2| 2| 2| 3| 3| 3| 3| 3| 3|         U  V   I|
25MG/KG R 2YR 11    11                      | 2| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 6| 7| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  APOPTOSIS,LYMPHOCYTE                      |                                                                           |     1 3.0|
LYMPH NODE,MESENTERIC                       | +                                      +     +                            |  8       |
  APOPTOSIS,LYMPHOCYTE                      |                                                                           |     1 4.0|
  DEGENERATION                              |                                         3                                 |     1 3.0|
SPLEEN                                      | +     +                    +                 +           +                |  8       |
  APOPTOSIS,LYMPHOCYTE                      |                                                                           |     1 4.0|
  HEMATOPOIETIC CELL PROLIFERATION          |  4     3                    3                                             |     4 3.2|
THYMUS                                      | M                                                                         |  2       |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M                                                                         |  0       |
SKIN                                        | +                                                                         |  4       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +                                                                         |  4       |
BONE,FEMUR                                  | +                                                                         |  4       |
BONE,STERNUM                                | +                                                                         |  4       |
SKELETAL MUSCLE                             | +                                                                         |  4       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +                                                                         |  4       |
BRAIN,CEREBELLUM                            | +                                                                         |  4       |
BRAIN,CEREBRUM                              | +                                                                         |  4       |
  HYDROCEPHALUS                             |                                                                           |     1 2.0|
  MINERALIZATION,THALAMUS                   |  2                                                                        |     2 2.0|
PERIPHERAL NERVE                            | +                                                                         |  4       |
SPINAL CORD                                 | +                                                                         |  3       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +                                                                         |  4       |
LUNG                                        | +                                                  +                      |  6       |
NOSE                                        | +                                                                         |  4       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   62
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:26.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 2| 2| 2| 3| 3| 3| 3| 3| 3| 6| 6| 7| 7| 2| 2| 2| 3| 3| 3| 3| 3| 3|         U  V   I|
25MG/KG R 2YR 11    11                      | 2| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 3| 6| 7| 7| 8| 9| 0| 1| 2| 3| 4| 5|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
RESPIRATORY SYSTEM

TRACHEA                                     | +                                                                         |  4       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EAR                                         |                                                                           |  1       |
EYE                                         | +                                                                         |  4       |
HARDERIAN GLAND                             | +                    +  +                          +                      |  8       |
LACRIMAL GLAND                              | +                                                                         |  4       |
ZYMBAL'S GLAND                              | M                                                                         |  3       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +                                                                         |  4       |
  INFARCT,UNILATERAL                        |                                                                           |     1 3.0|
URINARY BLADDER                             | +                                                                         |  4       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   63
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:27.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4|   S  R   R|
                                            | 0| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|   U  V   I|
50 MG/KGR 2YR 12    12                      | 6| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 1| 2| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +                                                                         |          |
GALLBLADDER                                 | +                                                                         |          |
INTESTINE LARGE                             | +                                                                         |          |
INTESTINE LARGE,CECUM                       | +                                                                         |          |
INTESTINE LARGE,COLON                       | +                                                                         |          |
INTESTINE LARGE,RECTUM                      | +                                                                         |          |
INTESTINE SMALL                             | +                                                                         |          |
INTESTINE SMALL,DUODENUM                    | +                                                                         |          |
INTESTINE SMALL,ILEUM                       | +                                                                         |          |
INTESTINE SMALL,JEJUNUM                     | +                                                                         |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  BASOPHILIC FOCUS                          |                                                                           |          |
  CLEAR CELL FOCUS                          |                                                                   X     X |          |
  CYST                                      |                                              X                            |          |
  HYPERPLASIA,FOCAL,ITO CELL                |                                                                           |          |
PANCREAS                                    | +                                                                         |          |
SALIVARY GLANDS                             | +                                                                         |          |
STOMACH                                     | +                                                                         |          |
STOMACH,FORESTOMACH                         | +                                                                         |          |
STOMACH,GLANDULAR                           | +                                                                         |          |
TONGUE                                      | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +                                                                         |          |
HEART                                       | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +                                                                         |          |
ADRENAL GLAND,CORTEX                        | +                                                                         |          |
ADRENAL GLAND,MEDULLA                       | +                                                                         |          |
ISLETS, PANCREATIC                          | +                                                                         |          |
PARATHYROID GLAND                           | M                                                                         |          |
PITUITARY GLAND                             | +                                                                         |          |
THYROID GLAND                               | M                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   64
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:27.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4|   S  R   R|
                                            | 0| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|   U  V   I|
50 MG/KGR 2YR 12    12                      | 6| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 1| 2| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

COAGULATING GLAND                           | +                                                                         |          |
EPIDIDYMIS                                  | +                                                                         |          |
PREPUTIAL GLAND                             | +                                                                         |          |
PROSTATE                                    | +                                                                         |          |
SEMINAL VESICLE                             | +                                                                         |          |
TESTES                                      | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +                                                                         |          |
LYMPH NODE                                  | +                                                                         |          |
LYMPH NODE,MANDIBULAR                       | +                                                                         |          |
LYMPH NODE,MESENTERIC                       | +                                                                         |          |
  DEGENERATION                              |                                                                           |          |
SPLEEN                                      | +                                                                         |          |
  HEMATOPOIETIC CELL PROLIFERATION          |                                                                           |          |
THYMUS                                      | +                                                                         |          |
  APOPTOSIS                                 |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M                                                                         |          |
SKIN                                        | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +                                                                         |          |
BONE,FEMUR                                  | +                                                                         |          |
BONE,STERNUM                                | +                                                                         |          |
SKELETAL MUSCLE                             | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       | +                                                                         |          |
BRAIN,CEREBELLUM                            | +                                                                         |          |
BRAIN,CEREBRUM                              | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   65
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:27.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4|   S  R   R|
                                            | 0| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|   U  V   I|
50 MG/KGR 2YR 12    12                      | 6| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 1| 2| 6| 7| 1| 2| 3| 4| 5| 6| 7| 8| 9| 6|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

PERIPHERAL NERVE                            | +                                                                         |          |
SPINAL CORD                                 | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +                                                                         |          |
LUNG                                        | +              +                                                          |          |
  HEMORRHAGE,FOCAL,RIGHT,APICAL LOBE,SUBPLEU|                                                                           |          |
    RA                                      |                                                                           |          |
NOSE                                        | +                                                                         |          |
TRACHEA                                     | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +                                                                         |          |
HARDERIAN GLAND                             | +                                                                         |          |
LACRIMAL GLAND                              | +                                                                         |          |
ZYMBAL'S GLAND                              | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +                                                                         |          |
URINARY BLADDER                             | +                                                                         |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   66
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:27.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5|         U  V   I|
50 MG/KGR 2YR 12    12                      | 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| 5| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   |                                                                           |  1       |
GALLBLADDER                                 |                                                                           |  1       |
INTESTINE LARGE                             |                                                                           |  1       |
INTESTINE LARGE,CECUM                       |                                                                           |  1       |
INTESTINE LARGE,COLON                       |                                                                           |  1       |
INTESTINE LARGE,RECTUM                      |                                                                           |  1       |
INTESTINE SMALL                             |                                                                           |  1       |
INTESTINE SMALL,DUODENUM                    |                                                                           |  1       |
INTESTINE SMALL,ILEUM                       |                                                                           |  1       |
INTESTINE SMALL,JEJUNUM                     |                                                                           |  1       |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  BASOPHILIC FOCUS                          |                      X     X                                              |     2    |
  CLEAR CELL FOCUS                          |                                                                           |     2    |
  CYST                                      |                                                                           |     1    |
  HYPERPLASIA,FOCAL,ITO CELL                |                                3                                          |     1 3.0|
PANCREAS                                    |                                                                           |  1       |
SALIVARY GLANDS                             |                                                                           |  1       |
STOMACH                                     |                                                                           |  1       |
STOMACH,FORESTOMACH                         |                                                                           |  1       |
STOMACH,GLANDULAR                           |                                                                           |  1       |
TONGUE                                      |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                |                                                                           |  1       |
HEART                                       |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               |                                                                           |  1       |
ADRENAL GLAND,CORTEX                        |                                                                           |  1       |
ADRENAL GLAND,MEDULLA                       |                                                                           |  1       |
ISLETS, PANCREATIC                          |                                                                           |  1       |
PARATHYROID GLAND                           |                                                                           |  0       |
PITUITARY GLAND                             |                                                                           |  1       |
THYROID GLAND                               |                                                                           |  0       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   67
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:27.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5|         U  V   I|
50 MG/KGR 2YR 12    12                      | 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| 5| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

COAGULATING GLAND                           |                                                                           |  1       |
EPIDIDYMIS                                  |                                                                           |  1       |
PREPUTIAL GLAND                             |                                                                           |  1       |
PROSTATE                                    |                                                                           |  1       |
SEMINAL VESICLE                             |                                                                           |  1       |
TESTES                                      |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 |                                                                           |  1       |
LYMPH NODE                                  | +                                         +                               |  3       |
LYMPH NODE,MANDIBULAR                       |                                                                           |  1       |
LYMPH NODE,MESENTERIC                       | +                                         +                               |  3       |
  DEGENERATION                              |                                            3                              |     1 3.0|
SPLEEN                                      | +  +                                         +                            |  4       |
  HEMATOPOIETIC CELL PROLIFERATION          |                                               3                           |     1 3.0|
THYMUS                                      |                                                                           |  1       |
  APOPTOSIS                                 |                                                                           |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               |                                                                           |  0       |
SKIN                                        |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        |                                                                           |  1       |
BONE,FEMUR                                  |                                                                           |  1       |
BONE,STERNUM                                |                                                                           |  1       |
SKELETAL MUSCLE                             |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
NERVOUS SYSTEM

BRAIN                                       |                                                                           |  1       |
BRAIN,CEREBELLUM                            |                                                                           |  1       |
BRAIN,CEREBRUM                              |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   68
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:28.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 7| 7| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5|         U  V   I|
50 MG/KGR 2YR 12    12                      | 7| 8| 9| 0| 1| 2| 3| 4| 5| 4| 5| 8| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 4|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

PERIPHERAL NERVE                            |                                                                           |  1       |
SPINAL CORD                                 |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      |                                                                           |  1       |
LUNG                                        |                               +                 +              +          |  5       |
  HEMORRHAGE,FOCAL,RIGHT,APICAL LOBE,SUBPLEU|                                                  1                        |     1 1.0|
    RA                                      |                                                                           |          |
NOSE                                        |                                                                           |  1       |
TRACHEA                                     |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         |                                                                           |  1       |
HARDERIAN GLAND                             |                                              +                            |  2       |
LACRIMAL GLAND                              |                                                                           |  1       |
ZYMBAL'S GLAND                              |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      |                                                                           |  1       |
URINARY BLADDER                             |                                                                           |  1       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   69
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:39.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6|   U  V   I|
100MG/KGR 2YR 13    13                      | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
GALLBLADDER                                 | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  HEMORRHAGE                                |     2                                                                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                       2   |          |
INTESTINE LARGE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
INTESTINE LARGE,CECUM                       | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  2  3                                                                     |          |
INTESTINE LARGE,COLON                       | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  2  3                                                                     |          |
INTESTINE LARGE,RECTUM                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
INTESTINE SMALL                             | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
INTESTINE SMALL,DUODENUM                    | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  2  3                                                                     |          |
INTESTINE SMALL,ILEUM                       | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  2  3                                                                     |          |
INTESTINE SMALL,JEJUNUM                     | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  2  3                                                                     |          |
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  BASOPHILIC FOCUS                          |                                  X                    X                   |          |
  CYST                                      |                                                                           |          |
  NECROSIS,HEPATOCYTE                       |        4                                                                  |          |
  THROMBUS                                  |        4                                                                  |          |
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,ACINAR CELL                       |                                               1                           |          |
  AUTOLYSIS                                 |  2                                                                        |          |
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |                       3                                                   |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                    2  2  2|          |
STOMACH                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
STOMACH,FORESTOMACH                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   70
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:39.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6|   U  V   I|
100MG/KGR 2YR 13    13                      | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CYST EPITHELIAL INCLUSION                 |                                                                           |          |
STOMACH,GLANDULAR                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2  3                                                                     |          |
  HYPERKERATOSIS                            |                                                                           |          |
  HYPERPLASIA                               |                                                                           |          |
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS,AORTA                           |  2                                                                        |          |
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  CARDIOMYOPATHY                            |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  + |          |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3        2                                                               |          |
  CYTOPLASMIC ALTERATION                    |                                   3  2                                    |          |
  HYPERPLASIA                               |                          3  2  2                                          |          |
  HYPERPLASIA,SPINDLE CELL                  |              2     2     2     2  2           2        1     2            |          |
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3        2                                                               |          |
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3        2                                                              3|          |
  CYST                                      |                                                 X                         |          |
PITUITARY GLAND                             | M  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  M |          |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3     3  2                                                              3|          |
  CYST,FOLLICLE                             |                                                             X             |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   71
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:40.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6|   U  V   I|
100MG/KGR 2YR 13    13                      | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

COAGULATING GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
EPIDIDYMIS                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3     2                                                               |          |
  GRANULOMA SPERM                           |                                         3                                 |          |
  INFLAMMATION,CHRONIC                      |                                                                           |          |
  SPERMATOCELE                              |                                                           2               |          |
PREPUTIAL GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY                                   |        2                                      3     3        3  3  2  2  3|          |
  AUTOLYSIS                                 |  3  3                                                                     |          |
  ECTASIA,DUCT                              |                                                                           |          |
  HYPERPLASIA                               |                    2                                                      |          |
PROSTATE                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  + |          |
  ATROPHY                                   |                                               2                           |          |
  AUTOLYSIS                                 |  3        2                                                              3|          |
  INFLAMMATION,ACUTE                        |        2                                                                  |          |
SEMINAL VESICLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3  3     2                                                               |          |
  INFLAMMATION,ACUTE                        |        3                                                                  |          |
TESTES                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A |          |
  AUTOLYSIS                                 |  3  3     2                                                               |          |
  DEGENERATION                              |                                                           1               |          |
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  HYPERPLASIA                               |     2  2                                                                  |          |
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,LYMPHOCYTE                        |  2                                                                        |          |
  AUTOLYSIS                                 |  2                                                                        |          |
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,LYMPHOCYTE                        |  2                                                                        |          |
  AUTOLYSIS                                 |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   72
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:40.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6|   U  V   I|
100MG/KGR 2YR 13    13                      | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  DEGENERATION                              |                                                                           |          |
  HYPERPLASIA                               |                                2                 3                    3   |          |
  PIGMENTATION                              |                                                  3                        |          |
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ATROPHY,LYMPHOCYTE                        |  2                                                                        |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  HEMATOPOIETIC CELL PROLIFERATION          |     3                                                                     |          |
  HYPERPLASIA,LYMPHOID                      |                                2                                          |          |
THYMUS                                      | +  M  A  M  +  +  M  +  +  +  +  M  M  +  M  +  M  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  CYST                                      |                                                                X          |          |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M |          |
  AUTOLYSIS                                 |  2                                                                        |          |
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  FIBROUS OSTEODYSTROPHY                    |                    3                                                      |          |
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  FIBROUS OSTEODYSTROPHY                    |                    2                                                  2   |          |
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |          |
  POLYARTERITIS                             |                                                                           |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   73
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:40.3
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6|   U  V   I|
100MG/KGR 2YR 13    13                      | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
BRAIN,CEREBRUM                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  MINERALIZATION,THALAMUS                   |                    2     2  2     1           2  1     2  2     1     2   |          |
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
  DEGENERATION                              |                                                                           |          |
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |                       1  1                                                |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                3                                   2      |          |
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  2                                                                        |          |
  GRANULOMA                                 |                                                                           |          |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |                                                                           |          |
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3        2                                                               |          |
  HYPERPLASIA,UNILATERAL                    |                                            3        3                     |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                    1      |          |
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  + |          |
  ATROPHY,FOCAL                             |                                         2                                 |          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   74
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:40.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 3| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|
                                            | 1| 8| 2| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2|
                                            | 1| 5| 8| 4| 1| 1| 1| 1| 1| 1| 1| 1| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 4|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|   S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|   S  R   R|
                                            | 0| 2| 6| 7| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 4| 4| 4| 6|   U  V   I|
100MG/KGR 2YR 13    13                      | 4| 1| 1| 7| 3| 4| 5| 6| 7| 8| 9| 0| 3| 4| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 1|   E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  AUTOLYSIS                                 |  2                                                                        |          |
ZYMBAL'S GLAND                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3                                                                        |          |
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  ACCUMULATION HYALINE DROPLET,RENAL TUBULE |                                                                           |          |
  AUTOLYSIS                                 |  2     2                                                                  |          |
  DEGENERATION,RENAL TUBULE                 |           1              1                       1  2                     |          |
  GLOMERULOSCLEROSIS                        |                                                                           |          |
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                2                                          |          |
  REGENERATION,RENAL TUBULE                 |           1              1                       1  2                     |          |
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  + |          |
  AUTOLYSIS                                 |  3        2                                                              3|          |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   75
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:50.7
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5|         U  V   I|
100MG/KGR 2YR 13    13                      | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

ESOPHAGUS                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4                                                                        |     2 3.5|
GALLBLADDER                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +       | 43       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
  HEMORRHAGE                                |                                                                           |     1 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
INTESTINE LARGE                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
INTESTINE LARGE,CECUM                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  AUTOLYSIS                                 |                                                                           |     2 2.5|
INTESTINE LARGE,COLON                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 45       |
  AUTOLYSIS                                 |                                                                           |     2 2.5|
INTESTINE LARGE,RECTUM                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
INTESTINE SMALL                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
INTESTINE SMALL,DUODENUM                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  AUTOLYSIS                                 |                                                                           |     2 2.5|
INTESTINE SMALL,ILEUM                       | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  AUTOLYSIS                                 |                                                                           |     2 2.5|
INTESTINE SMALL,JEJUNUM                     | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 44       |
  AUTOLYSIS                                 |                                                                           |     2 2.5|
LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
  BASOPHILIC FOCUS                          |                                                                           |     2    |
  CYST                                      | X                                                                         |     1    |
  NECROSIS,HEPATOCYTE                       |  3                                                                        |     2 3.5|
  THROMBUS                                  |                                                                           |     1 4.0|
PANCREAS                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY,ACINAR CELL                       |                                                                           |     1 1.0|
  AUTOLYSIS                                 |  4                                                                        |     2 3.0|
SALIVARY GLANDS                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY                                   |                                                                           |     1 3.0|
  AUTOLYSIS                                 |  3                                                                        |     2 2.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2        2                                          |     5 2.0|
STOMACH                                     | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
STOMACH,FORESTOMACH                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   76
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:50.9
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5|         U  V   I|
100MG/KGR 2YR 13    13                      | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

  CYST EPITHELIAL INCLUSION                 |                                           X                               |     1    |
STOMACH,GLANDULAR                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |                                                                           |     2 2.5|
  HYPERKERATOSIS                            |                                            3                              |     1 3.0|
  HYPERPLASIA                               |                                            3                              |     1 3.0|
TONGUE                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4                                                                        |     2 3.5|
------------------------------------------------------------------------------------------------------------------------------------
CARDIOVASCULAR SYSTEM

BLOOD VESSEL                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS,AORTA                           |                                                                           |     1 2.0|
HEART                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
  CARDIOMYOPATHY                            |                    1              1                                       |     2 1.0|
------------------------------------------------------------------------------------------------------------------------------------
ENDOCRINE SYSTEM

ADRENAL GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
ADRENAL GLAND,CORTEX                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  3                                                                        |     3 2.6|
  CYTOPLASMIC ALTERATION                    |                                                     1     2               |     4 2.0|
  HYPERPLASIA                               |                                                                           |     3 2.3|
  HYPERPLASIA,SPINDLE CELL                  |        2  2     2     2  1  2  3  2     1     2  1  1  1  3     2  2      |    24 1.8|
ADRENAL GLAND,MEDULLA                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  3                                                                        |     3 2.6|
ISLETS, PANCREATIC                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
PARATHYROID GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4                                                                        |     4 3.0|
  CYST                                      |                                                                           |     1    |
PITUITARY GLAND                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +       | 38       |
THYROID GLAND                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4                                                                        |     5 3.0|
  CYST,FOLLICLE                             |                                                                           |     1    |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   77
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:51.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5|         U  V   I|
100MG/KGR 2YR 13    13                      | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
GENITAL SYSTEM

COAGULATING GLAND                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  3                                                                        |     3 3.0|
EPIDIDYMIS                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  3                                                                        |     4 2.7|
  GRANULOMA SPERM                           |                                                                           |     1 3.0|
  INFLAMMATION,CHRONIC                      |                       3                                                   |     1 3.0|
  SPERMATOCELE                              |                                                                           |     1 2.0|
PREPUTIAL GLAND                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ATROPHY                                   |     2                                   2     2  2           3            |    13 2.4|
  AUTOLYSIS                                 |  3                                                                        |     3 3.0|
  ECTASIA,DUCT                              |                                                              3            |     1 3.0|
  HYPERPLASIA                               |                                                                           |     1 2.0|
PROSTATE                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY                                   |                                                                           |     1 2.0|
  AUTOLYSIS                                 |  4                                                                        |     4 3.0|
  INFLAMMATION,ACUTE                        |                                                                           |     1 2.0|
SEMINAL VESICLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  3                                                                        |     4 2.7|
  INFLAMMATION,ACUTE                        |                                                                           |     1 3.0|
TESTES                                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  AUTOLYSIS                                 |                                                                           |     3 2.6|
  DEGENERATION                              |                                                                           |     1 1.0|
------------------------------------------------------------------------------------------------------------------------------------
HEMATOPOIETIC SYSTEM

BONE MARROW                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
  HYPERPLASIA                               |                                                                           |     2 2.0|
LYMPH NODE                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
LYMPH NODE,MANDIBULAR                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY,LYMPHOCYTE                        |                                                                           |     1 2.0|
  AUTOLYSIS                                 |  3                                                                        |     2 2.5|
LYMPH NODE,MESENTERIC                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY,LYMPHOCYTE                        |                                                                           |     1 2.0|
  AUTOLYSIS                                 |  3                                                                        |     2 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   78
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:51.2
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5|         U  V   I|
100MG/KGR 2YR 13    13                      | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
HEMATOPOIETIC SYSTEM

  DEGENERATION                              |                                   3                 1              3      |     3 2.3|
  HYPERPLASIA                               |                                                                           |     3 2.6|
  PIGMENTATION                              |                                                                           |     1 3.0|
SPLEEN                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  ATROPHY,LYMPHOCYTE                        |                                                              2            |     2 2.0|
  AUTOLYSIS                                 |  4                                                                        |     2 3.0|
  HEMATOPOIETIC CELL PROLIFERATION          |  4  3        3        3                    3                              |     6 3.1|
  HYPERPLASIA,LYMPHOID                      |                                                                           |     1 2.0|
THYMUS                                      | +  M  M  +  M  +  +  M  +  M  M  M  M  +  +  +  M  +  +  +  +  M  +       | 30       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
  CYST                                      |                                                                           |     1    |
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

MAMMARY GLAND                               | M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M       |  2       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
SKIN                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
MUSCULOSKELETAL SYSTEM

BONE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BONE,FEMUR                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
  FIBROUS OSTEODYSTROPHY                    |                                                                           |     1 3.0|
BONE,STERNUM                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
  FIBROUS OSTEODYSTROPHY                    |                                                                           |     2 2.0|
SKELETAL MUSCLE                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4                                                                        |     2 3.5|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |           1                                                               |     1 1.0|
  POLYARTERITIS                             |                                         3                                 |     1 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   79
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:51.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5|         U  V   I|
100MG/KGR 2YR 13    13                      | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
NERVOUS SYSTEM

BRAIN                                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
BRAIN,CEREBELLUM                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
BRAIN,CEREBRUM                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  MINERALIZATION,THALAMUS                   |  2                                   2     2  2  2        1  2  2  2      |    19 1.7|
PERIPHERAL NERVE                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4                                                                        |     2 3.5|
  DEGENERATION                              |        2                                                                  |     1 2.0|
SPINAL CORD                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
RESPIRATORY SYSTEM

LARYNX                                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4                                                                        |     2 3.5|
LUNG                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
  HYPERPLASIA,ALVEOLAR EPITHELIUM           |  2                    2              2                                    |     5 1.6|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     2 2.5|
NOSE                                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |                                                                           |     1 2.0|
  GRANULOMA                                 | X                                                                         |     1    |
TRACHEA                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4                                                                        |     2 3.5|
------------------------------------------------------------------------------------------------------------------------------------
SPECIAL SENSES SYSTEM

EYE                                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4                                                                        |     1 4.0|
HARDERIAN GLAND                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4                                                                        |     3 3.0|
  HYPERPLASIA,UNILATERAL                    |                                                                           |     2 3.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                       2                                                   |     2 1.5|
LACRIMAL GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 46       |
  ATROPHY,FOCAL                             |                                                                           |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   80
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:51.5
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
                                            | 8| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3| 2| 3| 3|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|         S  E   V|
MALE                        CARCASS ID      | 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|         S  R   R|
                                            | 7| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 8| 8| 4| 4| 4| 4| 4| 5| 5| 5| 5|         U  V   I|
100MG/KGR 2YR 13    13                      | 8| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 0| 1| 5| 6| 7| 8| 9| 0| 1| 2| 3|         E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
SPECIAL SENSES SYSTEM

  AUTOLYSIS                                 |  3                                                                        |     2 2.5|
ZYMBAL'S GLAND                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  AUTOLYSIS                                 |  4                                                                        |     2 3.5|
------------------------------------------------------------------------------------------------------------------------------------
URINARY SYSTEM

KIDNEY                                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 47       |
  ACCUMULATION HYALINE DROPLET,RENAL TUBULE |     4                                      3                              |     2 3.5|
  AUTOLYSIS                                 |                                                                           |     2 2.0|
  DEGENERATION,RENAL TUBULE                 |                                                                           |     4 1.2|
  GLOMERULOSCLEROSIS                        |     2        2        2                                                   |     3 2.0|
  INFILTRATION CELLULAR,LYMPHOCYTIC         |                                                                           |     1 2.0|
  REGENERATION,RENAL TUBULE                 |                                                                           |     4 1.2|
URINARY BLADDER                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +       | 48       |
  AUTOLYSIS                                 |  4                                                                        |     4 3.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   81
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:52.0
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3|                                          S  R   R|
                                            | 2| 2| 2| 4| 4| 4| 2| 2| 2| 4| 4| 4|                                          U  V   I|
CONTROL R 64W 14    14                      | 2| 3| 4| 6| 7| 8| 3| 4| 5| 7| 8| 9|                                          E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +                                        | 12       |
  FATTY CHANGE,PERIPHERAL                   |                    2                                                      |     1 2.0|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                          2                                                |     1 2.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   82
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:52.4
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3|                                          S  R   R|
                                            | 2| 2| 2| 4| 5| 5| 2| 2| 2| 5| 5| 5|                                          U  V   I|
25 MG/KGR 64W 15    15                      | 5| 6| 7| 9| 0| 1| 6| 7| 8| 0| 1| 2|                                          E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +                                        | 12       |
  FATTY CHANGE,PERIPHERAL                   |     2  3                                                                  |     2 2.5|
  GRANULOMA,MULTIPLE                        |       X                                                                   |     1    |
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                    1           2                                          |     2 1.5|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   83
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:52.8
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3|                                          S  R   R|
                                            | 2| 2| 3| 5| 5| 5| 2| 3| 3| 5| 5| 5|                                          U  V   I|
50 MG/KGR 64W 16    16                      | 8| 9| 0| 2| 3| 4| 9| 0| 1| 3| 4| 5|                                          E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +                                        | 12       |
  FATTY CHANGE,PERIPHERAL                   |              1                 2                                          |     2 1.5|
  VACUOLIZATION CYTOPLASMIC,CENTRILOBULAR   |                 2     2                                                   |     2 2.0|
------------------------------------------------------------------------------------------------------------------------------------
INTEGUMENTARY SYSTEM

SKIN                                        |                                  +                                        |  1       |
  ATROPHY,FOCAL,HAIR FOLLICLE               |                                   4                                       |     1 4.0|
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED

NCTR EXP/TEST:   211701                                                                                      PAGE:   84
                                             INDIVIDUAL ANIMAL NON-TUMOR PATHOLOGY TABLE                     DATE: 02/15/2000
                                                         PATHOLOGY REPORT 4                                  TIME: 14:31:53.1
------------------------------------------------------------------------------------------------------------------------------------
                            DAYS ON         | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
                            TEST            | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
                                            | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
                                            | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5|
------------------------------------------------------------------------------------------------------------------------      O   S|
------------------------------------------------------------------------------------------------------------------------   T  B   E|
                                            | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          I  S   V|
Mice-C57Bl/6N XC3H/HEN MTN-NCTR             | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                          S  E   V|
MALE                        CARCASS ID      | 0| 0| 0| 0| 0| 0| 3| 3| 3| 3| 3| 3|                                          S  R   R|
                                            | 3| 3| 3| 5| 5| 5| 3| 3| 3| 5| 5| 5|                                          U  V   I|
100MG/KGR 64W 17    17                      | 1| 2| 3| 5| 6| 7| 2| 3| 4| 6| 7| 8|                                          E  E   T|
------------------------------------------------------------------------------------------------------------------------   S  D   Y|
---------------------------------------------------------------------------------------------------------------------------------- |
ALIMENTARY SYSTEM

LIVER                                       | +  +  +  +  +  +  +  +  +  +  +  +                                        | 12       |
------------------------------------------------------------------------------------------------------------------------------------
+ : TISSUE EXAMINED MICROSCOPICALLY                 M : MISSING TISSUE                        1-4 : LESION QUALIFIED AS:
X : LESION PRESENT BUT NOT QUALIFIED                A : AUTOLYSIS PRECLUDES EXAMINATION               1) MINIMAL  3) MODERATE
I : INSUFFICIENT TISSUE                        BLANK : NOT EXAMINED                                     2) MILD    4)MARKED