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TDMS Study 05094-03 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                       BUTYL BENZYL PHTHALATE


NTP Experiment-Test: 05094-03                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 04/04/95
Route: DOSED FEED                                                                                                 Time: 22:08:25


                                                        RESTRICTED CORE


       Facility:  Southern Research Institute

       Chemical CAS #:  85-68-7

       Lock Date:  11/25/92

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    UNTREATDCONTROL
                               Include 002    UNTREATDCONTROL
                               Include 003    1.2%
                               Include 004    2.4%





























                                                             Page   1
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 6| 7| 9| 8| 9| 9| 9| 9| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9|             
                             DAY ON TEST   | 4| 9| 8| 0| 7| 4| 7| 1| 7| 6| 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7|             
                                           | 4| 4| 7| 2| 7| 4| 7| 4| 1| 7| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                   2      |             
      Parasite Metazoan                    |       X                 X                          X     X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3                                             |             
      Basophilic Focus                     | X  X  X  X  X     3     X        X  X  X     X  X  X  X        X  X     X|             
      Clear Cell Focus                     |                                                          2               |             
      Developmental Malformation           |                X                                                         |             
      Eosinophilic Focus                   |                                           X     X                        |             
      Granuloma                            |    2  1  1                                2  2  1                        |             
      Hematopoietic Cell Proliferation     |                      2                             2  1                  |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Subacute               |       2                                                                  |             
      Mixed Cell Focus                     |    X  X  X        3     X                                                |             
      Bile Duct, Hyperplasia               | 2                 1                                      2        1  1  1|             
      Centrilobular, Necrosis              |                      2                                                   |             
      Hepatocyte, Vacuolization Cytoplasmic| 3  2                 3                                                   |             
      Kupffer Cell, Pigmentation           |             2                                2                       3  1|             
      Lobules, Necrosis                    |                1                 1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                +                 +      |             
      Accessory Spleen                     |                X                                                  X      |             
      Fat, Necrosis                        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1     1     3     1     1        1           1  1        2     1        2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                   3      |             
      Mucosa, Hyperplasia                  |                                                                      1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                1     3                                                   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 6| 7| 9| 8| 9| 9| 9| 9| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9|             
                             DAY ON TEST   | 4| 9| 8| 0| 7| 4| 7| 1| 7| 6| 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7|             
                                           | 4| 4| 7| 2| 7| 4| 7| 4| 1| 7| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             2           2  1  1        3  2  2  2              1  1      |             
      Thrombosis                           |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       2                                                     X            |             
      Angiectasis                          |    1  1     1  2  1  2  3           2     3  1  1     1        1  2      |             
      Degeneration, Fatty                  |                      1  1                    1           2     1  2      |             
      Hyperplasia, Focal                   |       1     1        1  1                                                |             
      Hypertrophy, Focal                   |                                           1  1                 1         |             
      Necrosis                             |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1  2  1              3        2        1     4     1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       2        3     2  3              3        3                        |             
      Pars Distalis, Cyst                  |       X                 X                    X     X        X           3|             
      Pars Distalis, Hyperplasia, Focal    |                   1     1                    3           3     3         |             
      Pars Intermedia, Angiectasis         |                3                                      2                  |             
      Pars Intermedia, Cyst                | 3                                X                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                      X   |             
      C-Cell, Hyperplasia                  |                   1                          1  1        1              1|             
      Follicle, Cyst                       |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       3     4        2                    3  4                 2  4      |             
      Hyperplasia                          |                                           2  2  2                        |             
      Inflammation, Chronic                |                                     2  2        2                        |             
      Inflammation, Suppurative            |             2                             3                    1  3      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X              3                                                   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                    2                     |             
      Hyperplasia, Cystic                  |                                                       1        1         |             
                                            __________________________________________________________________________|             
   Vagina                                  | M                       +        M        M              M              M|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 6| 7| 9| 8| 9| 9| 9| 9| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9|             
                             DAY ON TEST   | 4| 9| 8| 0| 7| 4| 7| 1| 7| 6| 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7|             
                                           | 4| 4| 7| 2| 7| 4| 7| 4| 1| 7| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                    3  3                  |             
      Myelofibrosis                        |                2                                                     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +              +           +  +  +                 +  +  +  +     +     +|             
      Iliac, Ectasia                       |                                                    2  2                  |             
      Iliac, Hyperplasia, Lymphoid         |                                                    3  3                  |             
      Inguinal, Hyperplasia, Lymphoid      |                                                       3                  |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            | 3                          3                                            3|             
      Pancreatic, Pigmentation             |                                  2                                       |             
      Renal, Pigmentation                  |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2     2        2                                             |             
      Hemorrhage                           |                      1                                      2            |             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Pigmentation                         |    2     2     2  2        2                       2                    2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      4                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            2                                            2|             
      Hematopoietic Cell Proliferation     |       2  2           3              2  2  1  2     4  3                  |             
      Pigmentation, Hemosiderin            |          2  2           2  2           2  2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Ectasia                              | 2  3     2  2           2  1     2           1                           |             
      Galactocele                          |                X                                                         |             
      Hyperplasia                          |    1                          2        1  1     2     2  2     2  1  2  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  3                                       |             
      Hyperkeratosis                       |                                  3                                       |             
      Inflammation, Chronic                |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |             2              3        2     3              3               |             
      Femur, Osteopetrosis                 |             2              3        2     3  2           2               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 6| 7| 9| 8| 9| 9| 9| 9| 5| 7| 6| 9| 8| 9| 9| 6| 6| 9| 3| 9| 9| 4| 9|             
                             DAY ON TEST   | 4| 9| 8| 0| 7| 4| 7| 1| 7| 6| 7| 4| 8| 7| 5| 0| 7| 4| 4| 2| 5| 7| 7| 9| 7|             
                                           | 4| 4| 7| 2| 7| 4| 7| 4| 1| 7| 3| 7| 7| 7| 8| 0| 7| 9| 9| 8| 8| 7| 0| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    UNTREATD                               | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Compression                          |    3     4                                4                              |             
      Hemorrhage                           |    4                                                                     |             
      Hydrocephalus                        |          2                                3                              |             
      Necrosis                             |                               2                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                                     |             
      Hemorrhage                           |             1                                                            |             
      Infiltration Cellular, Histiocyte    |       1     1     1              1     1     1  2  1                    1|             
      Inflammation, Subacute               |                      2                                                   |             
      Alveolar Epithelium, Hyperplasia     |             1                       3           3                       1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |             3  3  3                    3     3                           |             
      Foreign Body                         |                                              2                           |             
      Fungus                               |                                        2                                 |             
      Mucosa, Hyperplasia                  |             1                          2     1                           |             
      Mucosa, Metaplasia, Squamous         |                   2                    2                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                         X|             
      Mineralization                       | 1  3  1  3  2  2  2  2  1  1  2  1  2  2  2  2  2  2  3  2     2  3  2  2|             
      Nephropathy                          | 1  1  1  2  1  1  2  1  1  2        1  1  2  1  1  1  1  1     1  1     1|             
      Renal Tubule, Hyperplasia            |                                              1                           |             
      Renal Tubule, Pigmentation           | 3  1  1  1  2  1  1  3  1  2  1  2  1  1  2  2  2  1  1  1     2  2  1  2|             
      Transitional Epithelium, Hyperplasia |          1                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9|            |
                             DAY ON TEST   | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7|            |
                                           | 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                          X               |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                            X              X                 X            |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    2                 3     2                                             |      4  2.5|
      Basophilic Focus                     | X  X  X  X  X     X     X  X  X     X           X     X           X  X  X|     32  3.0|
      Clear Cell Focus                     |                                                                         X|      2  2.0|
      Developmental Malformation           |                                                                          |      1     |
      Eosinophilic Focus                   |             X              X        X                       X        X  X|      8     |
      Granuloma                            | 1     1                       1     1                                   1|     11  1.3|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
      Hemorrhage                           |                                                    3                     |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                  X                                X      |      2     |
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Mixed Cell Focus                     | X           X     X           X                 X                       X|     11  3.0|
      Bile Duct, Hyperplasia               |             1  2  2                       2           1  2     3         |     13  1.6|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                3     4                                         3         |      6  3.0|
      Kupffer Cell, Pigmentation           |    2                          2        2                 2     3         |      9  2.1|
      Lobules, Necrosis                    |                                        2                    2            |      4  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   5        |
      Accessory Spleen                     |    X                                                                     |      3     |
      Fat, Necrosis                        |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 2     2        1           4  2     1  2  2     1  2     1  1     2  1   |     25  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Edema                                |                                                 2                        |      2  2.5|
      Mucosa, Hyperplasia                  | 2              3                                2                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9|            |
                             DAY ON TEST   | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7|            |
                                           | 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |    2                 1                                                   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2  1  2        1  1     3  1  2  3           1  2        1           2|     23  1.7|
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       1                    2                 1  1              2     2   |      8  1.6|
      Angiectasis                          | 1  1  2  1  1           1  2  1     2           2     2              1  1|     27  1.5|
      Degeneration, Fatty                  |    1  3  1  1        3        2           1                    3     1  1|     16  1.6|
      Hyperplasia, Focal                   |                                     1                          1         |      6  1.0|
      Hypertrophy, Focal                   |                               2           3                 1        2   |      7  1.6|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                          2     2         |     10  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |          3                                   3                           |      8  2.8|
      Pars Distalis, Cyst                  |                   3        3           3                          3      |     10  3.0|
      Pars Distalis, Hyperplasia, Focal    |          3                 3        2                             3      |      9  2.4|
      Pars Intermedia, Angiectasis         |                                                                          |      2  2.5|
      Pars Intermedia, Cyst                |          X                                                               |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |    1     1                    1     2                                    |      9  1.1|
      Follicle, Cyst                       |                            3        3                                   3|      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |             3  3  2                       4              2  3     3     3|     15  3.0|
      Hyperplasia                          |                   2                                                      |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9|            |
                             DAY ON TEST   | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7|            |
                                           | 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                            2                                             |      4  2.0|
      Inflammation, Suppurative            |                3                                                  2     2|      7  2.3|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | X        X  3                             X                              |      6  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |       2                                                                  |      2  2.0|
      Hyperplasia, Cystic                  |                1           1                       1  1                 1|      7  1.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    M  M     M     M                    M                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                                                                          |      2  3.0|
      Myelofibrosis                        |                                                                2         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +  +           +     +     +     +     +  +  +         |  21        |
      Iliac, Ectasia                       |                                                                          |      2  2.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      2  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                              2                           |      1  2.0|
      Mediastinal, Pigmentation            |                3                                   3     3  3            |      7  3.0|
      Pancreatic, Pigmentation             |                                                             2            |      2  2.0|
      Renal, Pigmentation                  |                                                          3               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      3  2.0|
      Hemorrhage                           |                                     3                 2              2  2|      6  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation                         | 2  2  2  2  2  2              2  3  2           2     3     2            |     19  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                     2                                    |      2  3.0|
      Hyperplasia, Lymphoid                |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             | 2              3                                         3     3         |      6  2.5|
      Hematopoietic Cell Proliferation     |                      3                          2                 2  2   |     13  2.3|
      Pigmentation, Hemosiderin            | 2  2  2     3                 2     2  2        2     2           2  2  2|     18  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9|            |
                             DAY ON TEST   | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7|            |
                                           | 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |       2  2     3  2  2     3  2  2     2  2     2     2     2           2|     22  2.0|
      Galactocele                          |                                                                      X   |      2     |
      Hyperplasia                          | 2           1              1  2     2              2  1  2        2      |     20  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                             2            |      2  2.5|
      Hyperkeratosis                       |                                                             2            |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Osteopetrosis               |                                                          2               |      6  2.5|
      Femur, Osteopetrosis                 |                                                                2         |      7  2.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          | 3     4     4  3              4  3              4     3     3     2  2   |     14  3.3|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrocephalus                        |                               3                                          |      3  2.7|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                  +                          +            |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                          +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                  3                    3                  |      3  2.3|
      Infiltration Cellular, Histiocyte    | 1                          1        1     1                          1   |     14  1.1|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |    X                                                                     |      6  3.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Fungus                               |    3                                                                     |      2  2.5|
      Mucosa, Hyperplasia                  |                                                                          |      3  1.3|
      Mucosa, Metaplasia, Squamous         |    2                                                                     |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 9| 7| 8| 7| 8| 6| 6| 9| 9| 4| 9| 7| 7| 4| 7| 7| 6| 7| 8| 8| 9| 9| 9|            |
                             DAY ON TEST   | 5| 2| 1| 4| 1| 9| 2| 8| 9| 7| 2| 7| 7| 9| 0| 9| 4| 5| 8| 5| 2| 7| 4| 7| 7|            |
                                           | 0| 2| 5| 0| 6| 6| 3| 3| 6| 7| 2| 8| 7| 3| 5| 8| 4| 4| 5| 4| 9| 2| 9| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    UNTREATD                               | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Mineralization                       |    2  3        1  2  3  1  2  2  2  1  1     2  2  1  2  1  1  2  2  2  2|     45  1.9|
      Nephropathy                          | 1  1  3  1  2  1     1  1  1  2  1  1  1        2        1  1  1     2  2|     40  1.3|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           | 1  1  1  1  1  3  1  1  1  1  2  1  1  1  1  1  1  2  1     1  2  2  1  1|     48  1.4|
      Transitional Epithelium, Hyperplasia |                                                          1               |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8|             
                             DAY ON TEST   | 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9| 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4|             
                                           | 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X  X     X     X                                                        X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2                                                                        |             
      Parasite Metazoan                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X  X  X  X  X  X     X  X     X  2  X  3  X     X  X     X  X  X     X|             
      Eosinophilic Focus                   |    X              X              X     X           X        X  X  X      |             
      Granuloma                            |          1              1                                      1  1      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X              X     X           X                 X      |             
      Mixed Cell Focus                     |                                                                          |             
      Thrombosis                           |                      2                       2                           |             
      Bile Duct, Hyperplasia               |                1        1                          1  1                  |             
      Kupffer Cell, Pigmentation           |                2  2  3  2              2  1     3  4     2  1  2        1|             
      Lobules, Necrosis                    |                                                             1        2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                +        +|             
      Accessory Spleen                     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  1  1  1        2     1  1     1  2  1        2     2  1     1         |             
      Acinar Cell, Hyperplasia, Focal      |                                                          1               |             
      Acinus, Metaplasia, Goblet Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                         1                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                      1   |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                 +                                      +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  2  2  3  1  2     2              2  2  2  2  3        1     3  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8|             
                             DAY ON TEST   | 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9| 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4|             
                                           | 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         2     2              1                 1  2     2|             
      Angiectasis                          | 1  3  1  1  1     1  1  2  1  1           3  2     2  4     2  2  2     1|             
      Degeneration, Fatty                  |    1        2     1           3                                   1  3  2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                  2  2                                    |             
      Hyperplasia, Focal                   |             2  1                                                         |             
      Hypertrophy, Focal                   |             1                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                                  2     1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    1                     |             
      Metaplasia, Hepatocyte               |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       3        3           3                                             |             
      Pars Distalis, Cyst                  | 3  3     X                 X              X           X  3              3|             
      Pars Distalis, Hyperplasia, Focal    |                3  3        3     1  2  2  1                              |             
      Pars Intermedia, Angiectasis         |                            3                                   2         |             
      Pars Intermedia, Cyst                |                                  X  X                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                 2  3              1           1                  |             
      Follicle, Cyst                       |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3     2     3     3  3                 3  2                              |             
      Hyperplasia                          |                                                                         4|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |             2                                                            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   3     3                                         3      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                         2                          2                     |             
      Hyperplasia, Cystic                  |    2  2                    1                                         1   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +                                M        M               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8|             
                             DAY ON TEST   | 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9| 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4|             
                                           | 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                          |             
      Hyperplasia, Reticulum Cell          |                         2                                                |             
      Myelofibrosis                        |                      2                          3                        |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                   +     +  +  +                    +  +|             
      Mediastinal, Hemorrhage              |                                                                         3|             
      Mediastinal, Pigmentation            | 3                                                                        |             
      Pancreatic, Pigmentation             |                                                 3                        |             
      Renal, Pigmentation                  |                                                 4                       3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          2                                2           2              2   |             
      Hemorrhage                           |                            2                          2     2            |             
      Hyperplasia, Lymphoid                |    3     2  2                                      2              3      |             
      Pigmentation                         |    2        2     2     2  2  2                    2  2        2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   1      |             
      Hyperplasia, Lymphoid                |                         2                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 2                       2|             
      Hematopoietic Cell Proliferation     |    1                    2                       2           1            |             
      Hemorrhage                           |                               3                                          |             
      Pigmentation, Hemosiderin            |    1  2        2  2     2  2                       3  2     2  2  2  1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2  1  2                             2  2  3               |             
      Hyperplasia                          |       2     1              1        1  2  2  1     1        2     2  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                3  3     3  3                                            3|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Edema                                |                                                                         4|             
      Hyperkeratosis                       |                            2                                             |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                2  2     3                                               3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |             3     2        3           3                                 |             
      Femur, Osteopetrosis                 |             3              2           3                             3   |             
      Rib, Osteopetrosis                   |                            3                                             |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 9| 6| 9| 9| 9| 9| 9| 7| 8| 7| 6| 6| 9| 7| 7| 9| 9| 8| 9| 9| 8| 7| 8|             
                             DAY ON TEST   | 4| 1| 7| 3| 7| 7| 7| 2| 7| 1| 3| 7| 8| 9| 0| 4| 9| 7| 7| 3| 7| 0| 8| 7| 4|             
                                           | 5| 3| 7| 4| 7| 7| 7| 7| 1| 6| 2| 9| 4| 6| 7| 0| 6| 1| 7| 8| 7| 7| 6| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    2.4%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             3                                      3        2            |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                          1               |             
      Infiltration Cellular, Histiocyte    | 3  1  1     1        1  1  1                 2  1     2     2            |             
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |             3  3                                                         |             
      Fungus                               |                                                                          |             
      Mucosa, Hyperplasia                  |             2                                                            |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |       X                          X  X                             X      |             
      Inflammation, Suppurative            |                      1                    1                              |             
      Mineralization                       | 2  1  1     2  2  1     1              1        2  1  1  1        1  1   |             
      Nephropathy                          | 2  2  2  1  2  3  1  1  1  2     1  1  2  1  1  1  2  2  2  1  1  2  1  3|             
      Papilla, Necrosis                    |                2                                                         |             
      Renal Tubule, Atrophy                |                               3                                          |             
      Renal Tubule, Dilatation             | 2              3  1        2                             2        2      |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Necrosis               |                      1                                                   |             
      Renal Tubule, Pigmentation           | 3  1     2  2  1  2  2  1  2  1  1  3  3  2  3  3  2  2  2  2  2  2  2  2|             
      Transitional Epithelium, Hyperplasia | 2     1        2        2  2        3  1     1  1  2  2           2  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Transitional Epithelium, Hyperplasia |             1        2     2              2           2     2        3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7|            |
                             DAY ON TEST   | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4|            |
                                           | 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    2.4%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |       X                                                           X      |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                X                                                         |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Muscularis, Hyperplasia              |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                 2                        |      1  2.0|
      Basophilic Focus                     | X  X  X  X  X     X        X        X  X  X     X  X  X  X  X  X  X  X  X|     38  2.5|
      Eosinophilic Focus                   | X        X                 X           X              X                  |     13     |
      Granuloma                            |                                                                      2   |      5  1.2|
      Hematopoietic Cell Proliferation     |                                                                      2   |      1  2.0|
      Hepatodiaphragmatic Nodule           |             X        X                       X              X  X         |     10     |
      Mixed Cell Focus                     |                                                             X            |      1     |
      Thrombosis                           |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |                   1                          1  2        1     1  2     1|     11  1.2|
      Kupffer Cell, Pigmentation           | 3  3  3     3                                2  3  3  2              3   |     21  2.4|
      Lobules, Necrosis                    |                                     1                                1   |      4  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +        +                                       |   4        |
      Accessory Spleen                     |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    2        2        1                 1           2  1     1        1   |     22  1.3|
      Acinar Cell, Hyperplasia, Focal      |                                                                          |      1  1.0|
      Acinus, Metaplasia, Goblet Cell      |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Cyst                           |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |             3                                                            |      1  3.0|
      Ulcer                                |                            4                                             |      1  4.0|
      Mucosa, Hyperplasia                  |             2        1     3                                             |      4  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                              4                           |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7|            |
                             DAY ON TEST   | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4|            |
                                           | 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    2.4%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2        3  1  2     3  3           2        1              1     2  2|     26  2.0|
      Thrombosis                           | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       2  1  X  1        2     2  2  2     1     2           2            |     17  1.7|
      Angiectasis                          | 1  2  1  2  2     1        2  1     1     1  1  2  1  1  1  1  2     1  1|     37  1.5|
      Degeneration, Fatty                  |    1                 1  3  1              1              1               |     13  1.6|
      Hematopoietic Cell Proliferation     |                                                                      3   |      1  3.0|
      Hemorrhage                           |                                                             2           3|      4  2.3|
      Hyperplasia, Focal                   |                   2                                                      |      3  1.7|
      Hypertrophy, Focal                   |                                                                      2   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 1                       2                 1           1  2        2      |      9  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Metaplasia, Hepatocyte               |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           | 3     1                       1                                          |      6  2.3|
      Pars Distalis, Cyst                  |                         3                                            3  X|     11  3.0|
      Pars Distalis, Hyperplasia, Focal    |       2     4                 1           2     2        1     3  1     2|     16  2.1|
      Pars Intermedia, Angiectasis         |                               2                                          |      3  2.3|
      Pars Intermedia, Cyst                |             3        X              3           3              3         |      7  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                        1                                 |      6  1.5|
      Follicle, Cyst                       |                                                       3                  |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                   3     3  3              3        3                     |     12  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7|            |
                             DAY ON TEST   | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4|            |
                                           | 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    2.4%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
      Inflammation, Suppurative            |    1                                                                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | 3                                         3              3               |      6  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                                                          |      2  2.0|
      Hyperplasia, Cystic                  |             1                          1                 1               |      7  1.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  | M                                   M                                M   |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                                           2                              |      1  2.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
      Myelofibrosis                        |                                     3              3        2            |      5  2.6|
      Necrosis                             |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +              +  +     +  +  +        +  +  +        +           +|  18        |
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                              3              3            |      3  3.0|
      Pancreatic, Pigmentation             |                               3                             3           4|      4  3.3|
      Renal, Pigmentation                  |                                                 3                       4|      4  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              | 2                                               2                 2      |      7  2.0|
      Hemorrhage                           | 3                 2        1              2                              |      7  2.0|
      Hyperplasia, Lymphoid                |                                                          2               |      6  2.3|
      Pigmentation                         | 2  2     2     2  2        2                             2           2   |     17  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           | 3                                                                        |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |       3                             3                       2     3     3|      7  2.6|
      Hematopoietic Cell Proliferation     | 1                                         1           2                 2|      8  1.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            | 2     2  3  2     2        2              1  1     2     2        3  3   |     24  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              | 2  3  3                 2  3                       2                     |     12  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7|            |
                             DAY ON TEST   | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4|            |
                                           | 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    2.4%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |       1  2  2  2  1  1  1     2  2  2  2  2  2  2  1  2  2     1  1  2  1|     32  1.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                         3                                                |      6  3.0|
      Cyst Epithelial Inclusion            |                                     X                                    |      1     |
      Edema                                | 3                                                                        |      2  3.5|
      Hyperkeratosis                       |                         4                                                |      2  3.0|
      Inflammation, Chronic                |                         2                                                |      1  2.0|
      Ulcer                                |                                                                          |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Osteopetrosis               |       2     3                    2  3                                3   |      9  2.7|
      Femur, Osteopetrosis                 |       2     3                       3                                3   |      8  2.8|
      Rib, Osteopetrosis                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          | 2        4                                            3              2   |      7  2.7|
      Hemorrhage                           |                      1                                2                  |      2  1.5|
      Hydrocephalus                        |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                | 2                                                                        |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |       1     2              1        1  1  1           3  2     2     1   |     21  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                   3                       3     3  3                     |      6  3.0|
      Fungus                               |                                                 2                        |      1  2.0|
      Mucosa, Hyperplasia                  |                                           1           2                  |      3  1.7|
      Mucosa, Metaplasia, Squamous         |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                         +               |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 9| 9| 7| 7| 9| 6| 9| 6| 8| 8| 7| 5| 9| 9| 9| 8| 8| 8| 9| 9| 7| 8| 7| 8| 7|            |
                             DAY ON TEST   | 3| 2| 1| 3| 3| 8| 7| 3| 0| 7| 1| 3| 7| 7| 7| 7| 2| 3| 7| 7| 1| 5| 3| 8| 4|            |
                                           | 6| 8| 9| 1| 6| 4| 7| 4| 6| 2| 5| 0| 0| 7| 7| 1| 4| 8| 7| 7| 9| 8| 7| 5| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    2.4%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract                             |                3                                         3               |      2  3.0|
      Retina, Degeneration                 |                4                                         3               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |       X                 X              X           X        X            |      9     |
      Inflammation, Suppurative            |                                                                          |      2  1.0|
      Mineralization                       | 1  1  1  2  1     2  2  2  1  1  1        1  2     1  1     3  1         |     31  1.4|
      Nephropathy                          | 1  1  1  2  1  1  1  1  2  2  1  1  1  2  1  2  1  1  2  2  2  1  1  1  1|     49  1.4|
      Papilla, Necrosis                    |                         3                          3                     |      3  2.7|
      Renal Tubule, Atrophy                |                4                                   3        3            |      4  3.3|
      Renal Tubule, Dilatation             |                2                       2     3  2  2                 2   |     12  2.1|
      Renal Tubule, Hyperplasia            |                                                                         1|      1  1.0|
      Renal Tubule, Necrosis               |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  1  3  2     2  2  2  3  2  2  3  2  1  1  3  2  2  3  3|     48  2.1|
      Transitional Epithelium, Hyperplasia |    1     2     2     3     1        1  3  2  2  2  2  1  1  1           1|     29  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |                                                          X               |      1     |
      Transitional Epithelium, Hyperplasia |                2  1        1              4           1  4  3     2  3   |     16  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|             
                             DAY ON TEST   | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|             
                                           | 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2                                                                        |             
      Parasite Metazoan                    | X                    X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                   X           X                    X|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                            3                 2                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Basophilic Focus                     |                            X                                         X   |             
      Degeneration, Cystic                 |                                     2     2                              |             
      Developmental Malformation           |                                        X                             X   |             
      Eosinophilic Focus                   |    1                                                                     |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                      1   |             
      Hepatodiaphragmatic Nodule           |                                  X                                       |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               |    2  2           3  2  3  3  1  3  4  2  2  1  2  3     3  3  3  2      |             
      Hepatocyte, Hyperplasia, Focal       |                                                    2                     |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |                                  3        2              3        3      |             
      Lobules, Necrosis                    |                                                 1           2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +              +  +                                         +   |             
      Accessory Spleen                     |       X                                                                  |             
      Fat, Necrosis                        |          4              3  2                                         3   |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1  1  1  2     3           3           1  1  2     1  3  1  1  2  1  3|             
      Edema                                |                                                                          |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                              1                           |             
      Mucosa, Hyperplasia                  |             2                 2           1                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2                                                                        |             
      Erosion                              |          1                                                  3            |             
      Ulcer                                |                      2        3                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|             
                             DAY ON TEST   | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|             
                                           | 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |          3                                                               |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  3        1  2     2     1        3  3     2  2  3  2  2     3     3  2|             
      Inflammation, Chronic                |                                  2                                       |             
      Thrombosis                           |    3                       4                             3     X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    2     2                 2  2           2     2        3           1  2|             
      Angiectasis                          | 3  2     1                          1  2     2        1              1  2|             
      Degeneration, Fatty                  |             1                          1        2        3     1  2      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |             1        1     1              1                             2|             
      Hypertrophy, Focal                   |                                                                          |             
      Thrombosis                           |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1     1  1                                      4        2     3         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | 3                 X                                               X      |             
      Pars Distalis, Hyperplasia, Focal    | 4                             4                                   3      |             
      Pars Intermedia, Cyst                |                                                          3        X  3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1                    1              2                 1            |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | 3  3        X        X     3  3  X  3  X  3     X  X  3     X  X  X  3  3|             
      Hypospermia                          | 3  3     X  X        X  X        X  3  X  4  3     X  3  3  X  X  X  3  3|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          3        4        3     3              3        3     4        2|             
      Inflammation, Chronic                |    2              2  2  2     2        2  2     2                 2  3   |             
      Inflammation, Suppurative            |          3                 1     2              2     2        2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|             
                             DAY ON TEST   | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|             
                                           | 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     |       2              2  2        2  2     2                          2   |             
      Inflammation, Suppurative            | 2           1  3  1     2        1     1  1     1     3           3     1|             
      Epithelium, Hyperplasia              |          1  2     1                       1                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 3     2  1     2                                   2              1      |             
      Seminiferous Tubule, Atrophy         | 4        3                                         1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                      3   |             
      Myelofibrosis                        |                                  4        2                    3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +        +  +  +  +                 +     +  +     +  +  +  +      |             
      Deep Cervical, Hemorrhage            |                                                                          |             
      Inguinal, Pigmentation               |                                                                          |             
      Mediastinal, Pigmentation            |                                                    3     3  3            |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Pigmentation             |                         3                                      3  4      |             
      Renal, Pigmentation                  |                   3     4                 4                    4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Ectasia                              |    2     2                                            2              2   |             
      Hemorrhage                           |                                              1                           |             
      Hyperplasia, Lymphoid                |          4                       4                                   3   |             
      Pigmentation                         |                                                       2           2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2                                                           2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   2     4           1                             3      |             
      Hematopoietic Cell Proliferation     |       3  2                                                     2     3   |             
      Metaplasia, Lipocyte                 |    3                                                                     |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            | 2           2                                2                          2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3     2              2  2                    2     2     2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                             4            |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                             4            |             
      Inflammation, Chronic                |                                                             4            |             
      Ulcer                                |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|             
                             DAY ON TEST   | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|             
                                           | 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       3                  |             
      Hydrocephalus                        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    3                     |             
      Hemorrhage                           |                         2                                                |             
      Infiltration Cellular, Histiocyte    |    1                                         1                 3         |             
      Alveolar Epithelium, Hyperplasia     |       2                                                  3               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              | 3     X  X           X           X                    3           X      |             
      Foreign Body                         | 2  2  2  3                       2                                       |             
      Fungus                               | 3     3              3                                                   |             
      Mucosa, Hyperplasia                  | 2                    2           1           2                           |             
      Mucosa, Metaplasia, Squamous         | 2  2  2              2                 1                       2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Hemorrhage                           |          3                                                               |             
      Inflammation, Chronic                |          3                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Cyst                                 |    X                                                                     |             
      Mineralization                       | 1     1     1        1                                                   |             
      Nephropathy                          | 1  1  1  2     1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  2  1  1  1|             
      Thrombosis                           |                                                                          |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Necrosis               |                                           2     3                        |             
      Renal Tubule, Pigmentation           | 1  1  3  2  1  2  2  1  1  1  1  1  1  1  1  1  2  1  1  1  2  4  1  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 6| 7| 7| 6| 7| 7| 7| 8| 7| 7| 8| 7| 7| 8| 6| 7| 7| 7| 7| 7| 6| 8| 8|             
                             DAY ON TEST   | 9| 9| 1| 6| 0| 1| 4| 1| 7| 9| 9| 2| 1| 5| 3| 9| 6| 0| 9| 8| 4| 5| 8| 2| 9|             
                                           | 3| 7| 7| 8| 1| 9| 0| 0| 7| 7| 8| 3| 3| 7| 0| 7| 7| 3| 8| 5| 4| 5| 2| 3| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    UNTREATD                               | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                   1                                         1            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|            |
                                           | 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    UNTREATD                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                        X                                X|      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                          X               |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                     3                                    |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       2                  |      2  2.0|
      Basophilic Focus                     |    3                          2  X     1              X                  |      7  2.0|
      Degeneration, Cystic                 |                   2              1                    2                  |      5  1.8|
      Developmental Malformation           |                                                                          |      2     |
      Eosinophilic Focus                   |                                  X                                       |      2  1.0|
      Granuloma                            |          1                                                               |      1  1.0|
      Hematopoietic Cell Proliferation     |                         2                                                |      2  1.5|
      Hepatodiaphragmatic Nodule           |                                                                   X  X   |      3     |
      Thrombosis                           |                3                                   X                     |      2  3.0|
      Bile Duct, Hyperplasia               |    2  3     3  3     1  3  4  3  3  2  2  3     3  3  3           3  1  3|     36  2.6|
      Hepatocyte, Hyperplasia, Focal       |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                             3  3         |      2  3.0|
      Kupffer Cell, Pigmentation           |                                                                   2      |      5  2.6|
      Lobules, Necrosis                    |    3           3        3                                                |      5  2.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +              +        +     +     +                    +  +            |  12        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |                4        3     4     3                    3               |      9  3.2|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                             +            |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 1     3  3  3  1  2           3  3     1     3        3           1  1  1|     30  1.9|
      Edema                                |                                  2                                       |      1  2.0|
      Acinus, Cytoplasmic Alteration       |                                                                1         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                             2            |      1  2.0|
      Ulcer                                |                                                    2                     |      2  1.5|
      Mucosa, Hyperplasia                  |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|            |
                                           | 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    UNTREATD                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                  3                                       |      2  2.5|
      Erosion                              |                         1                                         1      |      4  1.5|
      Ulcer                                |                                           2                              |      3  2.3|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    3     1     3     2     2     1     3  2        2  1  3  2     1     1|     30  2.1|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Thrombosis                           |                         3                       3                        |      6  3.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |       1                                   2           3        1  1     1|     15  1.8|
      Angiectasis                          |    2     3        1              2     2     3        2  1  1  1     1  1|     21  1.7|
      Degeneration, Fatty                  |       3                    3              3              3  1        3   |     12  2.2|
      Hemorrhage                           |                                                          3               |      1  3.0|
      Hyperplasia, Focal                   |             1                                         1                  |      7  1.1|
      Hypertrophy, Focal                   |                            3           1     2                       3   |      4  2.3|
      Thrombosis                           |                                              3                 1         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    1  2                          1     1  2  1     1           1         |     14  1.6|
      Necrosis                             |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |                                  2     4                                 |      2  3.0|
      Pars Distalis, Cyst                  | X                 3        X     3                    3        X  3      |     10  3.0|
      Pars Distalis, Hyperplasia, Focal    | 1     3              1        2        2                             1   |      9  2.3|
      Pars Intermedia, Cyst                |       X  3              3                                                |      6  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1                                1  3                 1               |      8  1.4|
      Follicle, Cyst                       |                            X                                             |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|            |
                                           | 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    UNTREATD                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                           +                 +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      |          3  2     3     3  4     3  4              X  3     X     3  3   |     30  3.1|
      Hypospermia                          |    3     3  3  4  3     3  4  3  3  4        3  3  X  3  4  X  4  3  4  3|     39  3.3|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |          3        3     2              2                 2  2            |     14  2.8|
      Inflammation, Chronic                |       2                 3     2  2     3                    2           2|     17  2.2|
      Inflammation, Suppurative            | 2        3        1                                1     2           2   |     12  1.9|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     | 2  2  2  3     3     2  2           3  2        3  2  2  2     1     3   |     22  2.2|
      Inflammation, Suppurative            | 2  1  3  1           1                 1  3     2                 1  1  2|     23  1.7|
      Epithelium, Hyperplasia              | 2     2                 2        1     2           1              1      |     11  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |                      2                 2                                2|      9  1.9|
      Seminiferous Tubule, Atrophy         |                                        4                 3               |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                   3      |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +  +  +     +  +  +     +     +  +              +  +  +  +  +|  28        |
      Deep Cervical, Hemorrhage            |                                                                         3|      1  3.0|
      Inguinal, Pigmentation               |                                     3                                    |      1  3.0|
      Mediastinal, Pigmentation            |       3        3  3     2     3           3                          3   |     10  2.9|
      Pancreatic, Hemorrhage               |                                     4                                    |      1  4.0|
      Pancreatic, Pigmentation             |       3        3              4                                   3      |      7  3.3|
      Renal, Pigmentation                  |                         4                                                |      5  3.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                              3                           |      5  2.2|
      Hemorrhage                           |    2                                3  1              2                 3|      6  2.0|
      Hyperplasia, Lymphoid                |          3                             2                                 |      5  3.2|
      Pigmentation                         |    2                 2                                   2  2        2   |      8  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |          2                                                               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                         4  2  3                                   3     2|      9  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|            |
                                           | 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    UNTREATD                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                     3        4                       2  2|      8  2.6|
      Metaplasia, Lipocyte                 |                                                                          |      1  3.0|
      Necrosis                             |                                     4                                    |      1  4.0|
      Pigmentation, Hemosiderin            |          2              1        1           1                           |      8  1.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                         3              2                          2      |     10  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                         2                                                |      2  3.0|
      Cyst Epithelial Inclusion            |                         X                             X                  |      2     |
      Hyperkeratosis                       |             3           4                                                |      3  3.7|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Ulcer                                |                         3                                                |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Osteopetrosis               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                          2              2|      3  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |             3     1                          1           1        2  2   |      9  1.7|
      Alveolar Epithelium, Hyperplasia     |          2              2                                1           3   |      6  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |       X     X           3           X     3  3  3  X           X         |     16  3.0|
      Foreign Body                         |                                           2        2           2         |      8  2.1|
      Fungus                               |       3     3           4           2     3  4  3  3                     |     11  3.1|
      Mucosa, Hyperplasia                  |       2     2           3                    2     2           2  1      |     11  1.9|
      Mucosa, Metaplasia, Squamous         |             3           2                 2  3  3  2                     |     12  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 8| 6| 8| 6| 6| 8| 5| 7| 7| 8| 8| 6| 8| 8| 8| 7| 7| 8| 5| 7| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 9| 5| 9| 1| 9| 2| 1| 9| 1| 9| 9| 7| 9| 6| 3| 8| 5| 9| 9| 6| 6| 9| 1| 4|            |
                                           | 9| 7| 6| 7| 7| 8| 4| 6| 6| 9| 7| 7| 0| 7| 8| 9| 5| 4| 7| 7| 1| 1| 6| 9| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    UNTREATD                               | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      L     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                +         |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Calculus Micro Observation Only      |                                        X                                 |      1     |
      Cyst                                 |                                              X                           |      2     |
      Mineralization                       |                                        1                 2               |      6  1.2|
      Nephropathy                          | 1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     49  1.1|
      Thrombosis                           |                                                          1               |      1  1.0|
      Renal Tubule, Atrophy                |                                                                      2   |      1  2.0|
      Renal Tubule, Dilatation             |                         2                                   2            |      2  2.0|
      Renal Tubule, Necrosis               |                                     1                          3         |      4  2.3|
      Renal Tubule, Pigmentation           | 1  1  3  1  1  1  1  1  1  2  3  2  2  2  2  1  1  2  1  2  1  1  1  2  1|     50  1.4|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|             
                             DAY ON TEST   | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|             
                                           | 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.2%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X              X                 X                 X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          2                 2                       2        2        2   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             2        3   |             
      Basophilic Focus                     |                   X  X     3                    3                 2      |             
      Clear Cell Focus                     |          X                                                               |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                  X                                       |             
      Degeneration, Cystic                 |                                                                3         |             
      Eosinophilic Focus                   |                         2           X  3  X        X              3  3   |             
      Granuloma                            |                   3                                                      |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Mixed Cell Focus                     |                                                                          |             
      Thrombosis                           |                                        2                                 |             
      Bile Duct, Hyperplasia               |                3  3        3     3  2  3  1     3     3  2  2        3   |             
      Centrilobular, Necrosis              |             2                                                            |             
      Hepatocyte, Hyperplasia, Focal       |                                                             2            |             
      Hepatocyte, Vacuolization Cytoplasmic|    3                                                           3         |             
      Kupffer Cell, Pigmentation           |                2           3           2                                 |             
      Lobules, Necrosis                    |                                                          3              2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +        +  +  +                                 |             
      Accessory Spleen                     |                                        X                                 |             
      Fat, Necrosis                        |                         3        3  4                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1        3     3  2        3     3  1  2  3  2  3  1     1  1            |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Cytoplasmic Alteration       |          1                                                               |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                         3|             
      Erosion                              |             2                             3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|             
                             DAY ON TEST   | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|             
                                           | 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.2%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3        1  1  1  3     3  2  3  3     1  3  1  3  2     1  3     3  2  1|             
      Thrombosis                           |             X              3        3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  2     2  2  2  3     1     2  2         |             
      Angiectasis                          | 2     1  2        1        2     3     1  1     2  2              3  2   |             
      Cyst                                 |                                              X                           |             
      Degeneration, Fatty                  |             1                                      2           1         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                                           1                    1         |             
      Hypertrophy, Focal                   |                                                       2                  |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1        3                             2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |    X                 X     3              X                              |             
      Pars Distalis, Hyperplasia, Focal    |                               2           1     2                        |             
      Pars Intermedia, Angiectasis         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                             1     2  1   |             
      Follicle, Cyst                       |                                                    X                     |             
      Follicular Cell, Hyperplasia         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | 3           X                       3     X  3        X  X  3  X        3|             
      Hypospermia                          | 3        3  X     3     3  3     X  3  3  X  3  3  3  X  X  3  X  3  3  2|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 2        3  3     3              2                 2        3           2|             
      Hyperplasia                          |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|             
                             DAY ON TEST   | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|             
                                           | 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.2%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                | 2     2           3                    2           2     2     2         |             
      Inflammation, Suppurative            |                                                             1     3     2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpora Amylacea                     | 2  2                 2     2  2        2        3        2  2     2     2|             
      Inflammation, Suppurative            |                      1  1     2           1  4                          1|             
      Epithelium, Hyperplasia              |                                                       1           1      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    2  1                                                                  |             
      Seminiferous Tubule, Atrophy         |                                              4                    4      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |             2                                                            |             
      Myelofibrosis                        |       2                    3              2                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +           +        +  +     +  +        +     +     +  +|             
      Iliac, Hemorrhage                    |                                                                         3|             
      Mediastinal, Hemorrhage              |                                              3                           |             
      Mediastinal, Pigmentation            |                2                       3     2  4                        |             
      Pancreatic, Necrosis                 |                                                                          |             
      Pancreatic, Pigmentation             |                2           3                                             |             
      Renal, Pigmentation                  |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Ectasia                              |                                        2                                 |             
      Hemorrhage                           | 2                                               2                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         | 2                                                     2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   1      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                3  3        3           4              2        3     2   |             
      Hematopoietic Cell Proliferation     |       1     4                    3                                       |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Ectopic Parathyroid Gland            | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                    2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|             
                             DAY ON TEST   | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|             
                                           | 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.2%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                   3           3                                   3      |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                   4           3                                   3      |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                   3      |             
      Hydrocephalus                        |                                                                         2|             
      Necrosis                             |                            3                                             |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                           +  +                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +  +                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                               2                                          |             
      Infiltration Cellular, Histiocyte    | 1        1        1  1                                            1  2   |             
      Inflammation, Subacute               |                                           1                              |             
      Alveolar Epithelium, Hyperplasia     | 3                 1                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                   3                    3           3                     |             
      Foreign Body                         |                   2                                                      |             
      Fungus                               |                   3                    3           3                     |             
      Mucosa, Hyperplasia                  |                   2                    3           1                     |             
      Mucosa, Metaplasia, Squamous         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
      Inflammation, Chronic                |                         4                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                              2                           |             
      Mineralization                       |    1                                   1     3                    1      |             
      Nephropathy                          | 2  1  1  2  1  1  1  1  2  1     2  2  2  2  2  2  2  2  1  2  1  2  3  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 5| 5| 8| 6| 6| 8| 6| 7| 8| 5| 7| 7| 8| 6| 8| 8| 8| 7| 7| 7| 7| 8| 8| 6|             
                             DAY ON TEST   | 9| 7| 2| 9| 6| 7| 9| 3| 8| 7| 4| 3| 9| 4| 7| 4| 9| 9| 2| 2| 9| 3| 9| 9| 3|             
                                           | 7| 9| 1| 7| 9| 5| 7| 5| 5| 6| 0| 7| 6| 4| 4| 4| 7| 7| 3| 3| 8| 7| 7| 7| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    1.2%                                   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thrombosis                           |                            2                                             |             
      Renal Tubule, Dilatation             |                                              3                           |             
      Renal Tubule, Necrosis               |                            1                                             |             
      Renal Tubule, Pigmentation           | 2  2  2  2  3  2  2  2  1  2     3  3  2  2  2  2  2  2  2  2  2  2  2  2|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                              +                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              4                           |             
      Transitional Epithelium, Hyperplasia |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7|            |
                             DAY ON TEST   | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7|            |
                                           | 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    1.2%                                   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                   X     X                          X                     |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                   2        3                    2                        |      8  2.1|
      Ulcer                                |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                 2                        |      3  2.3|
      Basophilic Focus                     |          X  2           X                    X  1  X  X                  |     12  2.2|
      Clear Cell Focus                     |                         X                                                |      2     |
      Congestion                           |                                                             3            |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                                                                X         |      8  2.8|
      Granuloma                            |                                           1     1                        |      3  1.7|
      Hepatodiaphragmatic Nodule           |                                                       X                  |      2     |
      Mixed Cell Focus                     |                         X                                                |      1     |
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |          3     2     2     2     3           1     3  1        1  3  2  2|     24  2.3|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Hepatocyte, Hyperplasia, Focal       |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                            3                                      3      |      4  3.0|
      Kupffer Cell, Pigmentation           |    2     3        3        2                       2                     |      8  2.4|
      Lobules, Necrosis                    |                2     3     3                                             |      5  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                          +     +     +  +      |   9        |
      Accessory Spleen                     |                                                                X         |      2     |
      Fat, Necrosis                        |                         2                          3     3               |      6  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              | 2  1     1        1  1     1  1              1        2  1     3  1     2|     27  1.7|
      Inflammation, Chronic                |    4                                                                     |      1  4.0|
      Acinus, Cytoplasmic Alteration       |             1                                   1                        |      3  1.0|
      Acinus, Hyperplasia, Focal           |                            3              2                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7|            |
                             DAY ON TEST   | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7|            |
                                           | 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    1.2%                                   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |                2     2        3                                   2      |      6  2.3|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 3  1     1  1  2           1     3     2           2     3     1     2  2|     32  2.0|
      Thrombosis                           |                   3                                                      |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |    2                 1     3     2              1  2  1  2     2     3   |     18  1.9|
      Angiectasis                          | 2     2  2  2     1                       1  2  3  1  1        3     3   |     24  1.9|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  |                                           2                              |      4  1.5|
      Hematopoietic Cell Proliferation     |                         3                                                |      1  3.0|
      Hyperplasia, Focal                   | 1                                                                    2   |      4  1.3|
      Hypertrophy, Focal                   |                2                          2                              |      3  2.0|
      Necrosis                             |                                              2                           |      1  2.0|
      Thrombosis                           |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                   3                                                      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Angiectasis           |                                                 2                        |      1  2.0|
      Pars Distalis, Cyst                  |                                           3  X                    X      |      7  3.0|
      Pars Distalis, Hyperplasia, Focal    |    2                                      3        3     3     2  4  2   |     10  2.4|
      Pars Intermedia, Angiectasis         |          3                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |          3                                                               |      4  1.8|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                              1                           |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7|            |
                             DAY ON TEST   | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7|            |
                                           | 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    1.2%                                   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |             +                                                            |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular                      | X        3  3  3  3        3     X              3  3     X  X  3  3      |     23  3.0|
      Hypospermia                          | X     3  3  3  3  3     3  3     X        3  X  3  3  3  X  X  3  3  3  X|     40  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                   2                                                      |      9  2.4|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |             2                 2              2              2     2  2   |     13  2.1|
      Inflammation, Suppurative            |                                           2                    2         |      5  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corpora Amylacea                     | 2  2  3        2        3  3  2           2     2                 2      |     21  2.2|
      Inflammation, Suppurative            |    1           2     2        3  2     1  3     1        3               |     15  1.9|
      Epithelium, Hyperplasia              | 2                                                                 1      |      4  1.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |    2                 1        3                                          |      5  1.8|
      Seminiferous Tubule, Atrophy         |                                                          4  3            |      4  3.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypercellularity                     |                         3                                                |      2  2.5|
      Myelofibrosis                        |                            3  2                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +  +     +     +  +  +     +     +     +              +     +|  23        |
      Iliac, Hemorrhage                    |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |             3                                                            |      2  3.0|
      Mediastinal, Pigmentation            |             4                                      4                     |      6  3.2|
      Pancreatic, Necrosis                 |    4                                                                     |      1  4.0|
      Pancreatic, Pigmentation             |                      3                       3     3                     |      5  2.8|
      Renal, Pigmentation                  |                                                                   3      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                2                                                         |      2  2.0|
      Hemorrhage                           |    1                                      3                          2   |      5  2.0|
      Hyperplasia, Lymphoid                |    2                                                                     |      1  2.0|
      Pigmentation                         | 2        2        2                       2                              |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                      2   |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7|            |
                             DAY ON TEST   | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7|            |
                                           | 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    1.2%                                   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |             2                                                            |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrosis                             |                2           3     2           2        2  2        3  3   |     15  2.6|
      Hematopoietic Cell Proliferation     |                                                             2            |      4  2.5|
      Infiltration Cellular, Histiocyte    |                                                 2                        |      1  2.0|
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
      Necrosis                             |    3                                                                     |      1  3.0|
      Pigmentation, Hemosiderin            |                            2                             2     1         |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|  45        |
      Ectopic Parathyroid Gland            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          2  1     3                                   2                 2|      8  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Acanthosis                           |                   3                       3           2              2   |      7  2.7|
      Cyst Epithelial Inclusion            |                            X                                             |      1     |
      Hyperkeratosis                       |                   3                       3           2              3   |      7  3.0|
      Inflammation, Chronic                |                   2                       2           2                  |      3  2.0|
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Osteopetrosis                 |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |                                                       3                  |      2  3.0|
      Hydrocephalus                        |                2                                                         |      2  2.0|
      Necrosis                             |                            3                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                     3                                    |      1  3.0|
      Edema                                |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 1  2                    2                       1     1              1   |     12  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05094-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 04/04/95  
Route: DOSED FEED                                                                                                 Time: 22:08:25  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 8| 8| 8| 6| 8| 5| 8| 8| 5| 7| 0| 4| 8| 6| 8| 8| 8| 7| 0| 8| 5| 8| 7|            |
                             DAY ON TEST   | 2| 9| 4| 9| 0| 4| 6| 0| 2| 0| 3| 3| 9| 9| 9| 8| 9| 0| 9| 5| 5| 9| 8| 9| 7|            |
                                           | 3| 9| 4| 7| 7| 1| 9| 8| 7| 6| 6| 7| 0| 8| 7| 7| 7| 7| 7| 5| 4| 7| 9| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    1.2%                                   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Subacute               |          2                                                               |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                         2                                                |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |             3                    X        3           3                  |      7  3.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Fungus                               |                                  2        2                              |      5  2.6|
      Mucosa, Hyperplasia                  |                                  2     1                       1         |      6  1.7|
      Mucosa, Metaplasia, Squamous         |                                  2        1           2                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Mineralization                       |          1                                                               |      5  1.4|
      Nephropathy                          | 1  1  1  2  1  1  2  1  2  2  1  2     1  1  1  2  1  3  1  1  1  1  2  1|     48  1.5|
      Thrombosis                           |                            1                                             |      2  1.5|
      Renal Tubule, Dilatation             |    2              2                                                      |      3  2.3|
      Renal Tubule, Necrosis               |                3     3     3                                             |      4  2.5|
      Renal Tubule, Pigmentation           | 2  2  2  2  3  2  1  2  2  3  4  2     2  1  3  2  2  2  2     1  4  2  2|     47  2.1|
      Transitional Epithelium, Hyperplasia |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                         +|   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
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