TDMS Study 05094-99 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
BUTYL BENZYL PHTHALATE
NTP Experiment-Test: 05094-99 Report: PEIRPT03
Study Type: CHRONIC Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
05094/02 -VS- 05094/03 COMPARISON
Facility: SOUTHERN RESEARCH INSTITUTE
Chemical CAS #: 85-68-7
Lock Date: 11/25/92
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25004 Dead
25005 Interval Sacrifice 25003 Moribund
25019 Moribund Sacrifice 25020 Natural Death
25026 Other 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 AD LIB CONTROL
Include 002 AD LIB CONTROL
Include 005 RTD CONTROL
Include 006 RTD CONTROL
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 110
Scheduled Sacrifice 35
Early Deaths
Moribund Sacrifice 23 2
Natural Death 2
Dead 4
Moribund 11
Survivors
Terminal Sacrifice 25
Animals Examined Microscopically 50 52
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (52)
Parasite Metazoan 3 (6%) 6 (12%)
Intestine Large, Rectum (50) (52)
Parasite Metazoan 3 (6%) 4 (8%)
Intestine Large, Cecum (50) (52)
Edema 2 (4%)
Parasite Metazoan 2 (4%)
Intestine Small, Ileum (49) (52)
Ulcer 1 (2%)
Liver (50) (52)
Angiectasis 1 (2%)
Basophilic Focus 37 (74%) 41 (79%)
Clear Cell Focus 3 (6%) 3 (6%)
Developmental Malformation 1 (2%) 1 (2%)
Eosinophilic Focus 19 (38%) 13 (25%)
Granuloma 6 (12%) 8 (15%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 9 (18%) 3 (6%)
Inflammation, Subacute 3 (6%) 3 (6%)
Mixed Cell Focus 10 (20%) 5 (10%)
Bile Duct, Hyperplasia 10 (20%) 5 (10%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 7 (14%)
Kupffer Cell, Hyperplasia 1 (2%)
Kupffer Cell, Pigmentation 4 (8%) 1 (2%)
Lobules, Necrosis 6 (12%) 6 (12%)
Mesentery (10) (1)
Accessory Spleen 1 (10%) 1 (100%)
Fat, Necrosis 9 (90%)
Pancreas (50) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Atrophy 18 (36%) 28 (57%)
Acinus, Cytoplasmic Alteration 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%)
Salivary Glands (49) (51)
Atrophy 1 (2%)
Hyperplasia 1 (2%)
Stomach, Forestomach (50) (51)
Edema 2 (4%)
Ulcer 1 (2%)
Mucosa, Hyperplasia 1 (2%) 1 (2%)
Stomach, Glandular (50) (52)
Erosion 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Ulcer 3 (6%)
Tongue (3)
Epithelium, Hyperplasia 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (52)
Cardiomyopathy 16 (32%) 15 (29%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (52)
Accessory Adrenal Cortical Nodule 5 (10%) 12 (23%)
Angiectasis 22 (44%) 28 (54%)
Degeneration, Fatty 10 (20%) 12 (23%)
Hyperplasia, Focal 9 (18%) 4 (8%)
Hypertrophy, Focal 9 (18%) 9 (17%)
Adrenal Medulla (49) (51)
Hyperplasia 1 (2%) 3 (6%)
Pituitary Gland (49) (52)
Pars Distalis, Angiectasis 7 (14%) 8 (15%)
Pars Distalis, Cyst 24 (49%) 14 (27%)
Pars Distalis, Hyperplasia, Focal 12 (24%) 11 (21%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 4 (8%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (49) (51)
Ultimobranchial Cyst 2 (4%)
C-Cell, Hyperplasia 6 (12%) 1 (2%)
Follicle, Cyst 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (52)
Ectasia 12 (24%) 12 (23%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic 4 (8%)
Inflammation, Suppurative 3 (6%) 5 (10%)
Ovary (50) (52)
Cyst 3 (6%) 4 (8%)
Inflammation, Chronic 1 (2%)
Uterus (50) (52)
Hydrometra 2 (4%) 3 (6%)
Hyperplasia, Cystic 4 (8%) 7 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (52)
Hypercellularity 1 (2%)
Myelofibrosis 4 (8%) 2 (4%)
Lymph Node (12) (10)
Mediastinal, Hemorrhage 1 (8%) 1 (10%)
Mediastinal, Pigmentation 2 (17%) 3 (30%)
Pancreatic, Pigmentation 1 (8%) 1 (10%)
Renal, Hemorrhage 1 (10%)
Renal, Pigmentation 1 (8%)
Lymph Node, Mandibular (49) (51)
Ectasia 1 (2%) 3 (6%)
Hemorrhage 5 (10%) 5 (10%)
Hyperplasia, Lymphoid 6 (12%)
Pigmentation 12 (24%) 15 (29%)
Lymph Node, Mesenteric (50) (52)
Ectasia 1 (2%)
Hemorrhage 3 (6%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Spleen (50) (52)
Fibrosis 1 (2%) 3 (6%)
Hematopoietic Cell Proliferation 10 (20%) 13 (25%)
Hemorrhage 2 (4%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 19 (38%) 21 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (49) (52)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (52)
Ectasia 12 (24%) 17 (33%)
Galactocele 1 (2%)
Hyperplasia 30 (61%) 18 (35%)
Skin (50) (52)
Acanthosis 1 (2%) 3 (6%)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 3 (6%) 1 (2%)
Inflammation, Chronic 1 (2%)
Ulcer 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (52)
Cranium, Osteopetrosis 7 (14%) 12 (23%)
Femur, Osteopetrosis 5 (10%) 7 (13%)
Rib, Osteopetrosis 1 (2%)
Skeletal Muscle (1)
Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (52)
Compression 9 (18%) 5 (10%)
Gliosis 1 (2%)
Hydrocephalus 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (52)
Congestion 2 (4%)
Edema 1 (2%)
Infiltration Cellular, Histiocyte 21 (42%) 19 (37%)
Inflammation, Subacute 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 5 (10%)
Nose (50) (52)
Exudate 6 (12%)
Foreign Body 5 (10%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Fungus 3 (6%)
Mucosa, Hyperplasia 3 (6%) 1 (2%)
Mucosa, Metaplasia, Squamous 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (4)
Atrophy 1 (50%) 1 (25%)
Cataract 2 (50%)
Hemorrhage 1 (50%)
Retina, Degeneration 2 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (52)
Mineralization 43 (86%) 47 (90%)
Nephropathy 34 (68%) 41 (79%)
Renal Tubule, Cytoplasmic Alteration 1 (2%)
Renal Tubule, Dilatation 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Pigmentation 49 (98%) 50 (96%)
Transitional Epithelium, Hyperplasia 1 (2%)
Urinary Bladder (50) (52)
Edema 1 (2%)
Hyperplasia 1 (2%)
Mucosa, Hyperplasia 2 (4%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 110
Scheduled Sacrifice 34
Early Deaths
Moribund Sacrifice 19
Natural Death 3
Moribund 14
Dead 1
Survivors
Terminal Sacrifice 28
Accidently Killed 1
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (44) (49)
Dilatation 1 (2%)
Parasite Metazoan 5 (11%) 4 (8%)
Intestine Large, Rectum (49) (50)
Parasite Metazoan 10 (20%) 5 (10%)
Intestine Large, Cecum (47) (49)
Edema 3 (6%) 1 (2%)
Parasite Metazoan 1 (2%)
Ulcer 1 (2%) 1 (2%)
Liver (50) (50)
Angiectasis 1 (2%)
Basophilic Focus 22 (44%) 16 (32%)
Clear Cell Focus 15 (30%) 1 (2%)
Degeneration, Cystic 7 (14%)
Developmental Malformation 2 (4%)
Eosinophilic Focus 3 (6%) 6 (12%)
Granuloma 1 (2%)
Hematopoietic Cell Proliferation 2 (4%)
Hepatodiaphragmatic Nodule 1 (2%) 2 (4%)
Inflammation, Subacute 2 (4%)
Mixed Cell Focus 6 (12%) 1 (2%)
Bile Duct, Hyperplasia 39 (78%) 32 (64%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 6 (12%) 4 (8%)
Kupffer Cell, Hyperplasia 1 (2%)
Kupffer Cell, Pigmentation 1 (2%) 3 (6%)
Lobules, Necrosis 2 (4%) 1 (2%)
Mesentery (7) (7)
Accessory Spleen 2 (29%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Angiectasis 1 (14%)
Fat, Necrosis 5 (71%) 5 (71%)
Pancreas (50) (50)
Atrophy 29 (58%) 36 (72%)
Acinus, Cytoplasmic Alteration 1 (2%) 2 (4%)
Acinus, Hyperplasia, Focal 4 (8%)
Stomach, Forestomach (50) (50)
Edema 1 (2%) 1 (2%)
Ulcer 2 (4%)
Mucosa, Hyperplasia 2 (4%) 1 (2%)
Stomach, Glandular (50) (50)
Edema 2 (4%)
Erosion 2 (4%) 2 (4%)
Ulcer 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50)
Hypertrophy 2 (4%)
Inflammation, Subacute 2 (4%)
Heart (50) (50)
Cardiomyopathy 32 (64%) 25 (50%)
Inflammation, Chronic 1 (2%)
Thrombosis 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50)
Accessory Adrenal Cortical Nodule 11 (22%) 18 (36%)
Angiectasis 26 (52%)
Degeneration, Fatty 3 (6%) 4 (8%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Focal 7 (14%) 9 (18%)
Hypertrophy, Focal 2 (4%) 3 (6%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Medulla (50) (50)
Hyperplasia 6 (12%) 9 (18%)
Islets, Pancreatic (50) (50)
Hyperplasia 3 (6%) 1 (2%)
Pituitary Gland (50) (46)
Pars Distalis, Angiectasis 3 (6%) 2 (4%)
Pars Distalis, Cyst 3 (6%) 6 (13%)
Pars Distalis, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia, Focal 7 (14%) 13 (28%)
Pars Intermedia, Angiectasis 3 (6%)
Pars Intermedia, Cyst 1 (2%) 1 (2%)
Thyroid Gland (50) (50)
Ultimobranchial Cyst 2 (4%)
C-Cell, Hyperplasia 4 (8%) 5 (10%)
Follicle, Cyst 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50)
Atypia Cellular 28 (56%) 39 (78%)
Hypospermia 34 (68%) 38 (76%)
Preputial Gland (50) (50)
Ectasia 11 (22%) 16 (32%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic 25 (50%) 26 (52%)
Inflammation, Suppurative 9 (18%) 9 (18%)
Prostate (50) (49)
Corpora Amylacea 17 (34%) 22 (45%)
Inflammation, Suppurative 29 (58%) 22 (45%)
Epithelium, Hyperplasia 4 (8%) 5 (10%)
Seminal Vesicle (50) (50)
Dilatation 4 (8%) 1 (2%)
Testes (50) (50)
Interstitial Cell, Hyperplasia 4 (8%) 4 (8%)
Seminiferous Tubule, Atrophy 2 (4%) 4 (8%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Hypercellularity 1 (2%) 2 (4%)
Myelofibrosis 2 (4%) 5 (10%)
Lymph Node (23) (12)
Iliac, Hemorrhage 1 (4%)
Iliac, Hyperplasia, Lymphoid 1 (4%)
Iliac, Pigmentation 1 (4%)
Mediastinal, Hemorrhage 5 (22%) 1 (8%)
Mediastinal, Pigmentation 5 (22%) 7 (58%)
Pancreatic, Pigmentation 4 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Renal, Hyperplasia, Lymphoid 1 (4%)
Renal, Pigmentation 2 (9%) 1 (8%)
Lymph Node, Mandibular (49) (48)
Congestion 1 (2%)
Ectasia 6 (12%) 5 (10%)
Hemorrhage 4 (8%) 5 (10%)
Hyperplasia, Lymphoid 3 (6%) 2 (4%)
Pigmentation 2 (4%) 10 (21%)
Lymph Node, Mesenteric (50) (50)
Ectasia 6 (12%) 2 (4%)
Hemorrhage 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 2 (4%) 1 (2%)
Spleen (50) (50)
Developmental Malformation 1 (2%)
Fibrosis 5 (10%) 7 (14%)
Hematopoietic Cell Proliferation 2 (4%) 5 (10%)
Metaplasia, Osseous 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 14 (28%) 6 (12%)
Lymphoid Follicle, Hyperplasia 1 (2%)
Thymus (49) (46)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (45) (49)
Hyperplasia 10 (22%) 7 (14%)
Skin (50) (49)
Acanthosis 2 (4%)
Hemorrhage 1 (2%)
Hyperkeratosis 2 (4%)
Inflammation, Chronic, Focal 1 (2%)
Metaplasia, Osseous 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Cranium, Osteopetrosis 1 (2%) 2 (4%)
Femur, Osteopetrosis 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Compression 4 (8%) 2 (4%)
Hydrocephalus 2 (4%) 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Congestion 1 (2%)
Edema 1 (2%)
Infiltration Cellular, Histiocyte 13 (26%) 4 (8%)
Inflammation, Subacute 1 (2%) 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 5 (10%)
Nose (50) (50)
Exudate 17 (34%) 5 (10%)
Foreign Body 8 (16%)
Fungus 12 (24%) 4 (8%)
Mucosa, Hyperplasia 11 (22%) 3 (6%)
Mucosa, Metaplasia, Squamous 9 (18%) 3 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Atrophy 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Calculus Micro Observation Only 1 (2%)
Mineralization 5 (10%)
Nephropathy 48 (96%) 43 (86%)
Renal Tubule, Dilatation 2 (4%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Pigmentation 49 (98%) 47 (94%)
Transitional Epithelium, Hyperplasia 6 (12%) 1 (2%)
Urinary Bladder (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05094-99 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 05/10/95
Route: DOSED FEED Time: 17:12:30
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE AD LIB RTD
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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