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https://ntp.niehs.nih.gov/go/3248

TDMS Study 05094-99 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       BUTYL BENZYL PHTHALATE


NTP Experiment-Test: 05094-99                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/10/95
Route: DOSED FEED                                                                                                 Time: 17:12:30


                                               05094/02 -VS- 05094/03 COMPARISON


       Facility:  SOUTHERN RESEARCH INSTITUTE

       Chemical CAS #:  85-68-7

       Lock Date:  11/25/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25004 Dead
                               25005 Interval Sacrifice                25003 Moribund
                               25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    AD LIB  CONTROL
                               Include 002    AD LIB  CONTROL
                               Include 005    RTD     CONTROL
                               Include 006    RTD     CONTROL

























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60          110                                                               

  Scheduled Sacrifice                                              35                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23            2                                                               
    Natural Death                                      2                                                                            
    Dead                                                            4                                                               
    Moribund                                                       11                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                25                                                                            

  Animals Examined Microscopically                    50           52                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (52)                                                             
      Parasite Metazoan                                3 (6%)       6 (12%)                                                         
   Intestine Large, Rectum                            (50)         (52)                                                             
      Parasite Metazoan                                3 (6%)       4 (8%)                                                          
   Intestine Large, Cecum                             (50)         (52)                                                             
      Edema                                            2 (4%)                                                                       
      Parasite Metazoan                                2 (4%)                                                                       
   Intestine Small, Ileum                             (49)         (52)                                                             
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)         (52)                                                             
      Angiectasis                                                   1 (2%)                                                          
      Basophilic Focus                                37 (74%)     41 (79%)                                                         
      Clear Cell Focus                                 3 (6%)       3 (6%)                                                          
      Developmental Malformation                       1 (2%)       1 (2%)                                                          
      Eosinophilic Focus                              19 (38%)     13 (25%)                                                         
      Granuloma                                        6 (12%)      8 (15%)                                                         
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       9 (18%)      3 (6%)                                                          
      Inflammation, Subacute                           3 (6%)       3 (6%)                                                          
      Mixed Cell Focus                                10 (20%)      5 (10%)                                                         
      Bile Duct, Hyperplasia                          10 (20%)      5 (10%)                                                         
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            7 (14%)                                                                      
      Kupffer Cell, Hyperplasia                        1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       4 (8%)       1 (2%)                                                          
      Lobules, Necrosis                                6 (12%)      6 (12%)                                                         
   Mesentery                                          (10)         (1)                                                              
      Accessory Spleen                                 1 (10%)      1 (100%)                                                        
      Fat, Necrosis                                    9 (90%)                                                                      
   Pancreas                                           (50)         (49)                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Atrophy                                         18 (36%)     28 (57%)                                                         
      Acinus, Cytoplasmic Alteration                   1 (2%)                                                                       
      Acinus, Hyperplasia, Focal                       1 (2%)                                                                       
   Salivary Glands                                    (49)         (51)                                                             
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (51)                                                             
      Edema                                            2 (4%)                                                                       
      Ulcer                                                         1 (2%)                                                          
      Mucosa, Hyperplasia                              1 (2%)       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (52)                                                             
      Erosion                                          1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            3 (6%)                                                                       
   Tongue                                             (3)                                                                           
      Epithelium, Hyperplasia                          1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (52)                                                             
      Cardiomyopathy                                  16 (32%)     15 (29%)                                                         
      Thrombosis                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (52)                                                             
      Accessory Adrenal Cortical Nodule                5 (10%)     12 (23%)                                                         
      Angiectasis                                     22 (44%)     28 (54%)                                                         
      Degeneration, Fatty                             10 (20%)     12 (23%)                                                         
      Hyperplasia, Focal                               9 (18%)      4 (8%)                                                          
      Hypertrophy, Focal                               9 (18%)      9 (17%)                                                         
   Adrenal Medulla                                    (49)         (51)                                                             
      Hyperplasia                                      1 (2%)       3 (6%)                                                          
   Pituitary Gland                                    (49)         (52)                                                             
      Pars Distalis, Angiectasis                       7 (14%)      8 (15%)                                                         
      Pars Distalis, Cyst                             24 (49%)     14 (27%)                                                         
      Pars Distalis, Hyperplasia, Focal               12 (24%)     11 (21%)                                                         
      Pars Intermedia, Angiectasis                                  1 (2%)                                                          
      Pars Intermedia, Cyst                                         4 (8%)                                                          
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
   Thyroid Gland                                      (49)         (51)                                                             
      Ultimobranchial Cyst                             2 (4%)                                                                       
      C-Cell, Hyperplasia                              6 (12%)      1 (2%)                                                          
      Follicle, Cyst                                                2 (4%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                                                              
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (52)                                                             
      Ectasia                                         12 (24%)     12 (23%)                                                         
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            4 (8%)                                                                       
      Inflammation, Suppurative                        3 (6%)       5 (10%)                                                         
   Ovary                                              (50)         (52)                                                             
      Cyst                                             3 (6%)       4 (8%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
   Uterus                                             (50)         (52)                                                             
      Hydrometra                                       2 (4%)       3 (6%)                                                          
      Hyperplasia, Cystic                              4 (8%)       7 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (52)                                                             
      Hypercellularity                                 1 (2%)                                                                       
      Myelofibrosis                                    4 (8%)       2 (4%)                                                          
   Lymph Node                                         (12)         (10)                                                             
      Mediastinal, Hemorrhage                          1 (8%)       1 (10%)                                                         
      Mediastinal, Pigmentation                        2 (17%)      3 (30%)                                                         
      Pancreatic, Pigmentation                         1 (8%)       1 (10%)                                                         
      Renal, Hemorrhage                                             1 (10%)                                                         
      Renal, Pigmentation                              1 (8%)                                                                       
   Lymph Node, Mandibular                             (49)         (51)                                                             
      Ectasia                                          1 (2%)       3 (6%)                                                          
      Hemorrhage                                       5 (10%)      5 (10%)                                                         
      Hyperplasia, Lymphoid                            6 (12%)                                                                      
      Pigmentation                                    12 (24%)     15 (29%)                                                         
   Lymph Node, Mesenteric                             (50)         (52)                                                             
      Ectasia                                          1 (2%)                                                                       
      Hemorrhage                                       3 (6%)       2 (4%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
   Spleen                                             (50)         (52)                                                             
      Fibrosis                                         1 (2%)       3 (6%)                                                          
      Hematopoietic Cell Proliferation                10 (20%)     13 (25%)                                                         
      Hemorrhage                                                    2 (4%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                       19 (38%)     21 (40%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (49)         (52)                                                             
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (52)                                                             
      Ectasia                                         12 (24%)     17 (33%)                                                         
      Galactocele                                                   1 (2%)                                                          
      Hyperplasia                                     30 (61%)     18 (35%)                                                         
   Skin                                               (50)         (52)                                                             
      Acanthosis                                       1 (2%)       3 (6%)                                                          
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                   3 (6%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                            2 (4%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (52)                                                             
      Cranium, Osteopetrosis                           7 (14%)     12 (23%)                                                         
      Femur, Osteopetrosis                             5 (10%)      7 (13%)                                                         
      Rib, Osteopetrosis                                            1 (2%)                                                          
   Skeletal Muscle                                    (1)                                                                           
      Hemorrhage                                       1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (52)                                                             
      Compression                                      9 (18%)      5 (10%)                                                         
      Gliosis                                          1 (2%)                                                                       
      Hydrocephalus                                    2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (52)                                                             
      Congestion                                                    2 (4%)                                                          
      Edema                                                         1 (2%)                                                          
      Infiltration Cellular, Histiocyte               21 (42%)     19 (37%)                                                         
      Inflammation, Subacute                           1 (2%)       1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 2 (4%)       5 (10%)                                                         
   Nose                                               (50)         (52)                                                             
      Exudate                                          6 (12%)                                                                      
      Foreign Body                                     5 (10%)      1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Fungus                                           3 (6%)                                                                       
      Mucosa, Hyperplasia                              3 (6%)       1 (2%)                                                          
      Mucosa, Metaplasia, Squamous                     3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (4)                                                              
      Atrophy                                          1 (50%)      1 (25%)                                                         
      Cataract                                                      2 (50%)                                                         
      Hemorrhage                                       1 (50%)                                                                      
      Retina, Degeneration                                          2 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (52)                                                             
      Mineralization                                  43 (86%)     47 (90%)                                                         
      Nephropathy                                     34 (68%)     41 (79%)                                                         
      Renal Tubule, Cytoplasmic Alteration             1 (2%)                                                                       
      Renal Tubule, Dilatation                         1 (2%)                                                                       
      Renal Tubule, Necrosis                           1 (2%)                                                                       
      Renal Tubule, Pigmentation                      49 (98%)     50 (96%)                                                         
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
   Urinary Bladder                                    (50)         (52)                                                             
      Edema                                            1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Mucosa, Hyperplasia                              2 (4%)                                                                       
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          60          110                                                               

  Scheduled Sacrifice                                              34                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19                                                                            
    Natural Death                                      3                                                                            
    Moribund                                                       14                                                               
    Dead                                                            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                28                                                                            
    Accidently Killed                                               1                                                               

  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (44)         (49)                                                             
      Dilatation                                       1 (2%)                                                                       
      Parasite Metazoan                                5 (11%)      4 (8%)                                                          
   Intestine Large, Rectum                            (49)         (50)                                                             
      Parasite Metazoan                               10 (20%)      5 (10%)                                                         
   Intestine Large, Cecum                             (47)         (49)                                                             
      Edema                                            3 (6%)       1 (2%)                                                          
      Parasite Metazoan                                             1 (2%)                                                          
      Ulcer                                            1 (2%)       1 (2%)                                                          
   Liver                                              (50)         (50)                                                             
      Angiectasis                                                   1 (2%)                                                          
      Basophilic Focus                                22 (44%)     16 (32%)                                                         
      Clear Cell Focus                                15 (30%)      1 (2%)                                                          
      Degeneration, Cystic                             7 (14%)                                                                      
      Developmental Malformation                                    2 (4%)                                                          
      Eosinophilic Focus                               3 (6%)       6 (12%)                                                         
      Granuloma                                                     1 (2%)                                                          
      Hematopoietic Cell Proliferation                              2 (4%)                                                          
      Hepatodiaphragmatic Nodule                       1 (2%)       2 (4%)                                                          
      Inflammation, Subacute                                        2 (4%)                                                          
      Mixed Cell Focus                                 6 (12%)      1 (2%)                                                          
      Bile Duct, Hyperplasia                          39 (78%)     32 (64%)                                                         
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            6 (12%)      4 (8%)                                                          
      Kupffer Cell, Hyperplasia                                     1 (2%)                                                          
      Kupffer Cell, Pigmentation                       1 (2%)       3 (6%)                                                          
      Lobules, Necrosis                                2 (4%)       1 (2%)                                                          
   Mesentery                                          (7)          (7)                                                              
      Accessory Spleen                                              2 (29%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Angiectasis                                      1 (14%)                                                                      
      Fat, Necrosis                                    5 (71%)      5 (71%)                                                         
   Pancreas                                           (50)         (50)                                                             
      Atrophy                                         29 (58%)     36 (72%)                                                         
      Acinus, Cytoplasmic Alteration                   1 (2%)       2 (4%)                                                          
      Acinus, Hyperplasia, Focal                       4 (8%)                                                                       
   Stomach, Forestomach                               (50)         (50)                                                             
      Edema                                            1 (2%)       1 (2%)                                                          
      Ulcer                                            2 (4%)                                                                       
      Mucosa, Hyperplasia                              2 (4%)       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)                                                             
      Edema                                            2 (4%)                                                                       
      Erosion                                          2 (4%)       2 (4%)                                                          
      Ulcer                                            2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)                                                             
      Hypertrophy                                      2 (4%)                                                                       
      Inflammation, Subacute                           2 (4%)                                                                       
   Heart                                              (50)         (50)                                                             
      Cardiomyopathy                                  32 (64%)     25 (50%)                                                         
      Inflammation, Chronic                                         1 (2%)                                                          
      Thrombosis                                       2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)                                                             
      Accessory Adrenal Cortical Nodule               11 (22%)     18 (36%)                                                         
      Angiectasis                                                  26 (52%)                                                         
      Degeneration, Fatty                              3 (6%)       4 (8%)                                                          
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Focal                               7 (14%)      9 (18%)                                                         
      Hypertrophy, Focal                               2 (4%)       3 (6%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (50)                                                             
      Hyperplasia                                      6 (12%)      9 (18%)                                                         
   Islets, Pancreatic                                 (50)         (50)                                                             
      Hyperplasia                                      3 (6%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (46)                                                             
      Pars Distalis, Angiectasis                       3 (6%)       2 (4%)                                                          
      Pars Distalis, Cyst                              3 (6%)       6 (13%)                                                         
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia, Focal                7 (14%)     13 (28%)                                                         
      Pars Intermedia, Angiectasis                     3 (6%)                                                                       
      Pars Intermedia, Cyst                            1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)                                                             
      Ultimobranchial Cyst                             2 (4%)                                                                       
      C-Cell, Hyperplasia                              4 (8%)       5 (10%)                                                         
      Follicle, Cyst                                   2 (4%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)                                                             
      Atypia Cellular                                 28 (56%)     39 (78%)                                                         
      Hypospermia                                     34 (68%)     38 (76%)                                                         
   Preputial Gland                                    (50)         (50)                                                             
      Ectasia                                         11 (22%)     16 (32%)                                                         
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                           25 (50%)     26 (52%)                                                         
      Inflammation, Suppurative                        9 (18%)      9 (18%)                                                         
   Prostate                                           (50)         (49)                                                             
      Corpora Amylacea                                17 (34%)     22 (45%)                                                         
      Inflammation, Suppurative                       29 (58%)     22 (45%)                                                         
      Epithelium, Hyperplasia                          4 (8%)       5 (10%)                                                         
   Seminal Vesicle                                    (50)         (50)                                                             
      Dilatation                                       4 (8%)       1 (2%)                                                          
   Testes                                             (50)         (50)                                                             
      Interstitial Cell, Hyperplasia                   4 (8%)       4 (8%)                                                          
      Seminiferous Tubule, Atrophy                     2 (4%)       4 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
      Hypercellularity                                 1 (2%)       2 (4%)                                                          
      Myelofibrosis                                    2 (4%)       5 (10%)                                                         
   Lymph Node                                         (23)         (12)                                                             
      Iliac, Hemorrhage                                1 (4%)                                                                       
      Iliac, Hyperplasia, Lymphoid                     1 (4%)                                                                       
      Iliac, Pigmentation                              1 (4%)                                                                       
      Mediastinal, Hemorrhage                          5 (22%)      1 (8%)                                                          
      Mediastinal, Pigmentation                        5 (22%)      7 (58%)                                                         
      Pancreatic, Pigmentation                                      4 (33%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Renal, Hyperplasia, Lymphoid                     1 (4%)                                                                       
      Renal, Pigmentation                              2 (9%)       1 (8%)                                                          
   Lymph Node, Mandibular                             (49)         (48)                                                             
      Congestion                                       1 (2%)                                                                       
      Ectasia                                          6 (12%)      5 (10%)                                                         
      Hemorrhage                                       4 (8%)       5 (10%)                                                         
      Hyperplasia, Lymphoid                            3 (6%)       2 (4%)                                                          
      Pigmentation                                     2 (4%)      10 (21%)                                                         
   Lymph Node, Mesenteric                             (50)         (50)                                                             
      Ectasia                                          6 (12%)      2 (4%)                                                          
      Hemorrhage                                       1 (2%)       2 (4%)                                                          
      Hyperplasia, Lymphoid                            2 (4%)       1 (2%)                                                          
   Spleen                                             (50)         (50)                                                             
      Developmental Malformation                                    1 (2%)                                                          
      Fibrosis                                         5 (10%)      7 (14%)                                                         
      Hematopoietic Cell Proliferation                 2 (4%)       5 (10%)                                                         
      Metaplasia, Osseous                              1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                       14 (28%)      6 (12%)                                                         
      Lymphoid Follicle, Hyperplasia                                1 (2%)                                                          
   Thymus                                             (49)         (46)                                                             
      Hemorrhage                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (49)                                                             
      Hyperplasia                                     10 (22%)      7 (14%)                                                         
   Skin                                               (50)         (49)                                                             
      Acanthosis                                                    2 (4%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Hyperkeratosis                                                2 (4%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Ulcer                                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Cranium, Osteopetrosis                           1 (2%)       2 (4%)                                                          
      Femur, Osteopetrosis                                          2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Compression                                      4 (8%)       2 (4%)                                                          
      Hydrocephalus                                    2 (4%)       1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Congestion                                       1 (2%)                                                                       
      Edema                                                         1 (2%)                                                          
      Infiltration Cellular, Histiocyte               13 (26%)      4 (8%)                                                          
      Inflammation, Subacute                           1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 7 (14%)      5 (10%)                                                         
   Nose                                               (50)         (50)                                                             
      Exudate                                         17 (34%)      5 (10%)                                                         
      Foreign Body                                     8 (16%)                                                                      
      Fungus                                          12 (24%)      4 (8%)                                                          
      Mucosa, Hyperplasia                             11 (22%)      3 (6%)                                                          
      Mucosa, Metaplasia, Squamous                     9 (18%)      3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                                           
      Atrophy                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Calculus Micro Observation Only                               1 (2%)                                                          
      Mineralization                                                5 (10%)                                                         
      Nephropathy                                     48 (96%)     43 (86%)                                                         
      Renal Tubule, Dilatation                                      2 (4%)                                                          
      Renal Tubule, Necrosis                                        1 (2%)                                                          
      Renal Tubule, Pigmentation                      49 (98%)     47 (94%)                                                         
      Transitional Epithelium, Hyperplasia             6 (12%)      1 (2%)                                                          
   Urinary Bladder                                    (50)         (50)                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05094-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/10/95  
Route: DOSED FEED                                                                                                 Time: 17:12:30  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
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