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TDMS Study 05094-99 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                       BUTYL BENZYL PHTHALATE


NTP Experiment-Test: 05094-99                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/11/95
Route: DOSED FEED                                                                                                 Time: 10:20:09


                                               05094/02 -VS- 05094/03 COMPARISON


       Facility:  SOUTHERN RESEARCH INSTITUTE

       Chemical CAS #:  85-68-7

       Lock Date:  11/25/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25004 Dead
                               25005 Interval Sacrifice                25003 Moribund
                               25019 Moribund Sacrifice                25020 Natural Death
                               25026 Other                             25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    AD LIB  CONTROL
                               Include 002    AD LIB  CONTROL
                               Include 005    RTD     CONTROL
                               Include 006    RTD     CONTROL

























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60          110                                                               

  Scheduled Sacrifice                                              35                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23            2                                                               
    Natural Death                                      2                                                                            
    Dead                                                            4                                                               
    Moribund                                                       11                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                25                                                                            

  Animals Examined Microscopically                    50           52                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (52)                                                             
   Intestine Small, Jejunum                           (50)         (52)                                                             
      Leiomyosarcoma                                                1 (2%)                                                          
   Liver                                              (50)         (52)                                                             
      Hepatocellular Adenoma                                        1 (2%)                                                          
   Mesentery                                          (10)         (1)                                                              
      Liposarcoma                                      1 (10%)                                                                      
   Pancreas                                           (50)         (49)                                                             
   Salivary Glands                                    (49)         (51)                                                             
   Stomach, Forestomach                               (50)         (51)                                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (52)                                                             
   Tongue                                             (3)                                                                           
      Squamous Cell Papilloma                          2 (67%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (52)                                                             
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (52)                                                             
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (2%)                                                          
   Adrenal Medulla                                    (49)         (51)                                                             
      Pheochromocytoma Malignant                                    1 (2%)                                                          

                                                             Page   2                                                               
NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                          1 (2%)       1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (49)                                                             
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (49)         (52)                                                             
      Pars Distalis, Adenoma                          19 (39%)     17 (33%)                                                         
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
      Pars Distalis, Carcinoma                         2 (4%)                                                                       
   Thyroid Gland                                      (49)         (51)                                                             
      C-Cell, Adenoma                                  4 (8%)       2 (4%)                                                          
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (52)                                                             
      Adenoma                                          3 (6%)       3 (6%)                                                          
      Carcinoma                                        4 (8%)                                                                       
   Ovary                                              (50)         (52)                                                             
      Granulosa Cell Tumor Benign                      2 (4%)       1 (2%)                                                          
   Uterus                                             (50)         (52)                                                             
      Adenoma                                                       1 (2%)                                                          
      Leiomyoma                                        1 (2%)                                                                       
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                    6 (12%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (52)                                                             
   Lymph Node                                         (12)         (10)                                                             
   Lymph Node, Mandibular                             (49)         (51)                                                             
   Lymph Node, Mesenteric                             (50)         (52)                                                             
   Spleen                                             (50)         (52)                                                             
   Thymus                                             (49)         (52)                                                             
      Thymoma Benign                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (52)                                                             
      Adenoma                                          2 (4%)                                                                       
      Carcinoma                                        2 (4%)       1 (2%)                                                          
      Fibroadenoma                                    28 (57%)     10 (19%)                                                         
      Fibroadenoma, Multiple                                        2 (4%)                                                          
   Skin                                               (50)         (52)                                                             
      Keratoacanthoma                                  1 (2%)       1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (52)                                                             
      Astrocytoma Malignant                                         1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
      Carcinoma, Metastatic, Pituitary Gland           2 (4%)                                                                       
      Oligodendroglioma Malignant                                   1 (2%)                                                          
   Spinal Cord                                                     (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (52)                                                             
      Alveolar/Bronchiolar Adenoma                     2 (4%)       1 (2%)                                                          
      Sarcoma, Metastatic, Tissue NOS                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (52)                                                             
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (50)         (52)                                                             
      Mast Cell Tumor Benign                                        1 (2%)                                                          

                                                             Page   4                                                               
NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(52)                                                             
      Leukemia Mononuclear                            21 (42%)     17 (33%)                                                         
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          44                                                               
     Total Primary Neoplasms                          112          72                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          31                                                               
     Total Benign Neoplasms                            77          45                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          25                                                               
     Total Malignant Neoplasms                         35          27                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                                                               
     Total Metastatic Neoplasm                          2           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60          110                                                               

  Scheduled Sacrifice                                              34                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                19                                                                            
    Natural Death                                      3                                                                            
    Moribund                                                       14                                                               
    Dead                                                            1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                28                                                                            
    Accidently Killed                                               1                                                               

  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (49)         (50)                                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Duodenum                          (50)         (50)                                                             
   Intestine Small, Jejunum                           (49)         (49)                                                             
      Leiomyoma                                        1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (49)                                                             
   Liver                                              (50)         (50)                                                             
      Hepatocellular Adenoma                           2 (4%)       1 (2%)                                                          
   Mesentery                                          (7)          (7)                                                              
      Sarcoma                                                       1 (14%)                                                         
   Oral Mucosa                                                     (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
   Pancreas                                           (50)         (50)                                                             
      Sarcoma, Metastatic, Mesentery                                1 (2%)                                                          
      Acinus, Adenoma                                  3 (6%)                                                                       
   Stomach, Forestomach                               (50)         (50)                                                             
      Leiomyosarcoma                                                1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)                                                             
   Tongue                                                          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)                                                             
   Adrenal Medulla                                    (50)         (50)                                                             
      Pheochromocytoma Malignant                       2 (4%)       1 (2%)                                                          
      Pheochromocytoma Benign                          6 (12%)      3 (6%)                                                          
      Pheochromocytoma Benign, Multiple                3 (6%)                                                                       
   Islets, Pancreatic                                 (50)         (50)                                                             
      Adenoma                                          5 (10%)      4 (8%)                                                          
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (50)         (46)                                                             
      Pars Distalis, Adenoma                           9 (18%)      4 (9%)                                                          
      Pars Distalis, Adenoma, Multiple                 1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)                                                             
      C-Cell, Adenoma                                  5 (10%)      4 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                      (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)                                                             
   Preputial Gland                                    (50)         (50)                                                             
      Adenoma                                          4 (8%)       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
   Prostate                                           (50)         (49)                                                             
   Seminal Vesicle                                    (50)         (50)                                                             
   Testes                                             (50)         (50)                                                             
      Bilateral, Interstitial Cell, Adenoma           37 (74%)     42 (84%)                                                         
      Interstitial Cell, Adenoma                       7 (14%)      5 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
   Lymph Node                                         (23)         (12)                                                             
      Iliac, Leiomyosarcoma, Metastatic, Intestine                                                                                  
          Large, Rectum                                1 (4%)                                                                       
   Lymph Node, Mandibular                             (49)         (48)                                                             
   Lymph Node, Mesenteric                             (50)         (50)                                                             

                                                             Page   8                                                               
NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Spleen                                             (50)         (50)                                                             
   Thymus                                             (49)         (46)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (45)         (49)                                                             
      Fibroadenoma                                     2 (4%)       2 (4%)                                                          
   Skin                                               (50)         (49)                                                             
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                  2 (4%)       2 (4%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     5 (10%)                                                                      
      Subcutaneous Tissue, Melanoma Malignant          1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Chordoma                                         1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                                           
      Hemangiosarcoma                                  1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Oligodendroglioma Malignant                      1 (2%)                                                                       
   Spinal Cord                                        (2)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Chordoma, Metastatic, Bone                       1 (2%)                                                                       
      Sarcoma, Metastatic, Mesentery                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            31 (62%)     21 (42%)                                                         
      Mesothelioma Malignant                           1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05094-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       BUTYL BENZYL PHTHALATE                                  Date: 05/11/95  
Route: DOSED FEED                                                                                                 Time: 10:20:09  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     AD LIB       RTD                                                                 
                                                   CONTROL      CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          49                                                               
     Total Primary Neoplasms                          135         100                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          48                                                               
     Total Benign Neoplasms                            94          69                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              37          29                                                               
     Total Malignant Neoplasms                         41          31                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                                                               
     Total Metastatic Neoplasm                          2           2                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
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