National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3258

TDMS Study 05094-99 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: SOUTHERN RESEARCH INST                              BUTYL BENZYL PHTHALATE                                DATE: 05/10/95       
EXPERIMENT: 05094 TEST: 99                                                                                     TIME: 17:28:46       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85222                              ROUTE: DOSED FEED                                              NTP C#: 54375C       
PATHOLOGIST: DR J. E. HEATH                                                                                    CAS: 85-68-7         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                 05094/02 -VS- 05094/03 COMPARISON                                                  
                                                                                                                                    

               REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                       25004 Dead                                                                                   
                                       25005 Interval Sacrifice                                                                     
                                       25003 Moribund                                                                               
                                       25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25026 Other                                                                                  
                                       25017 Scheduled Sacrifice                                                                    
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    AD LIB  CONTROL                                                               
                                       INCLUDE 002    AD LIB  CONTROL                                                               
                                       INCLUDE 005    RTD     CONTROL                                                               
                                       INCLUDE 006    RTD     CONTROL                                                               
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: SOUTHERN RESEARCH INST                              BUTYL BENZYL PHTHALATE                                DATE: 05/10/95      
EXPERIMENT: 05094 TEST: 99                                                                                     TIME: 17:28:46      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-85222                              ROUTE: DOSED FEED                                              NTP C#: 54375C      
PATHOLOGIST: DR J. E. HEATH                                                                                    CAS: 85-68-7        
                              BUTYL BENZYL PHTHALATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = AD LIB  CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 22     CENSORED DEATHS 10   TERMINAL 28        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      255   261   438   477   479   541   544   557   562   576                 |
 |      593   607   611   614   631   631   644   662   677   717                 |
 |      718   718                                                                 |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = RTD     CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 15     CENSORED DEATHS 10   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      432   467   507   549   583   600   645   645   655   681                 |
 |      682   696   709   719   723                                               |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================
                              BUTYL BENZYL PHTHALATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |AD         |   100.0 100.0  96.7  96.7  96.7  91.0  86.9  78.8  64.7  56.6      |
 |LIB  CONTRO|                                                                    |
 |           |                                                                    |
 |RTD        |   100.0 100.0 100.0 100.0 100.0  96.3  94.3  88.3  82.3  70.2      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                AD                        RTD                   |
 |                                LIB  CONTROL              CONTROL               |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       56.6%                     70.2%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----                     -----                |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       568.8                     619.5                 |
 |NATURAL DEATHS (C)      |       (26.9)                    (24.1)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       625.1                     656.3                 |
 |(STANDARD ERROR)        |       (16.7)                    (14.3)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                              BUTYL BENZYL PHTHALATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = AD LIB  CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 25     CENSORED DEATHS 10   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      39    368   512   570   587   598   668   670   681   684                 |
 |      691   702   702   703   711   713   716   717   717   717                 |
 |      719   725   725   725   726                                               |
 |  CENSORED DEATHS                                                               |
 |      459   459   459   459   459   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = RTD     CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 62     UNCENSORED DEATHS 17     CENSORED DEATHS 45   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      324   359   551   564   597   616   624   625   674   677                 |
 |      684   687   687   696   705   705   712                                   |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |      730   730   730   730   730   730   730   730   730   730                 |
 |      730   730   730   730   730   730   730   730   730   730                 |
 |      730   731   731   731   731   731   731   731   731   731                 |
 |      731   731   731   731   731                                               |
 |                                                                                |
 ==================================================================================
                              BUTYL BENZYL PHTHALATE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 736 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |AD         |    98.3  98.3  98.3  98.3  96.7  96.7  94.7  88.6  88.6  50.3      |
 |LIB  CONTRO|                                                                    |
 |           |                                                                    |
 |RTD        |   100.0 100.0 100.0  96.8  96.8  96.8  96.8  91.0  85.2  67.7      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                AD                        RTD                   |
 |                                LIB  CONTROL              CONTROL               |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       50.3%                     67.7%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----                     -----                |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       643.4                     616.9                 |
 |NATURAL DEATHS (C)      |       (30.3)                    (27.9)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       651.3                     655.2                 |
 |(STANDARD ERROR)        |       (17.6)                    (14.8)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                       BUTYL BENZYL PHTHALATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        AD LIB  CONTROL  = 1
                                                        RTD     CONTROL  = 2

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                        1                          2
      |                                          11                         2     2
      |
      |                                           1                          1    2     2
   95 +                                                                      1      1
      |                                                                                 2      2
      |                                                                                        2    2
      |                                                                             1         1
   90 +                                                                                             2  2
      |                                                                                                2      2
P     |                                                                                       1 1
E     |
R  85 +                                                                                         11
C     |                                                                                                       22
E     |                                                                                          1 1           2    2
N     |                                                                                            1  1
T  80 +
      |                                                                                               1 1           2 2
S     |
U     |                                                                                                 11            2 2
R  75 +
V     |                                                                                                                 22
I     |                                                                                                  1  1            22
V     |
A  70 +                                                                                                                   2 2
L     |                                                                                                     11
      |
      |                                                                                                      1   1
   65 +                                                                                                          1 1
      |
      |                                                                                                            1     1
      |
   60 +
      |
      |
      |                                                                                                                  1  1
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 1 obs hidden.
                                                       BUTYL BENZYL PHTHALATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        AD LIB  CONTROL  = 1
                                                        RTD     CONTROL  = 2

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1      1                                            2
      |        1                                            2    21
      |
      |                                                          21                      1     2
   95 +                                                                                  1     2 21
      |
      |                                                                                          21 1  2
      |                                                                                             1  1 2
   90 +
      |                                                                                                1 2 2      1
      |
      |
P  85 +                                                                                                    2      121
E     |
R     |
C     |                                                                                                            22
E  80 +                                                                                                             11
N     |                                                                                                             21 1
T     |
      |
S  75 +                                                                                                              22
U     |                                                                                                               22
R     |                                                                                                                11
V     |
I  70 +                                                                                                                22
V     |                                                                                                                 11
A     |                                                                                                                 2    2
L     |
   65 +
      |
      |
      |
   60 +
      |                                                                                                                  11
      |
      |
   55 +
      |
      |
      |
   50 +                                                                                                                   1  1
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.