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TDMS Study 05099-09 Pathology Tables


                                                    NEOPLASMS BY INDIVIDUAL ANIMAL
                                                      SALICYLAZOSULFAPYRIDINE


NTP Experiment-Test: 05099-09                                                                                     Report: PEIRPT04
Study Type: CHRONIC                                                                                               Date: 04/17/95
Route: GAVAGE                                                                                                     Time: 16:39:49


                                                          3 YEAR CORE


       Facility:  Southern Research Institute

       Chemical CAS #:  599-79-1

       Lock Date:  04/08/92

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25018 Dosing Accident
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/KG
                               Include 002    337.5   MG/KG




























Note:  Animals arranged according to CID number

                                                             Page   1

NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 8| 0| 8| 8| 7| 9| 3| 7| 9| 5| 8| 4| 7| 9| 5| 9| 8| 8| 7| 9| 8| 5| 7|             
                             DAY ON TEST   | 0| 0| 1| 3| 0| 4| 1| 1| 2| 1| 1| 9| 7| 4| 7| 1| 5| 1| 2| 4| 5| 1| 1| 7| 5|             
                                           | 9| 4| 6| 8| 9| 7| 7| 0| 7| 6| 0| 4| 5| 5| 0| 0| 6| 0| 6| 0| 8| 0| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Chordoma, Metastatic, Bone           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                    X                     |             
      Hepatocellular Adenoma               |       X                             X                                    |             
      Leukemia Mononuclear                 | X           X  X  X  X     X        X     X     X  X     X  X     X     X|             
      Osteosarcoma, Metastatic, Bone       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +     +     +              +              +     +                  |             
      Leukemia Mononuclear                 |             X                                   X                        |             
      Mesothelioma Malignant               |       X                                                                  |             
      Osteosarcoma, Metastatic, Bone       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X                             X     X                        |             
      Osteosarcoma, Metastatic, Bone       |                                                       X                  |             
      Acinar Cell, Adenoma                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Pharynx                                 |             +                                                            |             
      Squamous Cell Papilloma              |             X                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X                                                           X            |             
      Schwannoma Malignant                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   2                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 8| 0| 8| 8| 7| 9| 3| 7| 9| 5| 8| 4| 7| 9| 5| 9| 8| 8| 7| 9| 8| 5| 7|             
                             DAY ON TEST   | 0| 0| 1| 3| 0| 4| 1| 1| 2| 1| 1| 9| 7| 4| 7| 1| 5| 1| 2| 4| 5| 1| 1| 7| 5|             
                                           | 9| 4| 6| 8| 9| 7| 7| 0| 7| 6| 0| 4| 5| 5| 0| 0| 6| 0| 6| 0| 8| 0| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                X  X  X              X     X              X  X     X      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X     X        X              X                 X     X      |             
      Pheochromocytoma Malignant           |                                                    X                     |             
      Pheochromocytoma Benign              |                X                                         X               |             
      Bilateral, Pheochromocytoma Benign   |                                     X                                   X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                X                  |             
      Carcinoma                            |       X                                               X                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X              X                          X                 X            |             
      Pars Distalis, Adenoma               | X  X  X        X  X              X           X  X                        |             
      Pars Distalis, Leukemia Mononuclear  |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                  X                          X            |             
      C-Cell, Carcinoma                    |                                                          X               |             
      Follicular Cell, Adenoma             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                      X   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X  X        X  X  X  X     X  X     X  X  X  X     X  X  X     X  X     X|             
      Interstitial Cell, Adenoma           |                                                 X           X        X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X  X  X     X        X     X     X        X  X           X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +           +              +     +     +  +  +  +     +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   3                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 8| 0| 8| 8| 7| 9| 3| 7| 9| 5| 8| 4| 7| 9| 5| 9| 8| 8| 7| 9| 8| 5| 7|             
                             DAY ON TEST   | 0| 0| 1| 3| 0| 4| 1| 1| 2| 1| 1| 9| 7| 4| 7| 1| 5| 1| 2| 4| 5| 1| 1| 7| 5|             
                                           | 9| 4| 6| 8| 9| 7| 7| 0| 7| 6| 0| 4| 5| 5| 0| 0| 6| 0| 6| 0| 8| 0| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                X           X              X     X        X  X           X|             
      Mediastinal, Osteosarcoma,           |                                                                          |             
          Metastatic, Bone                 |                                                       X                  |             
      Pancreatic, Leukemia Mononuclear     |                            X                    X        X  X            |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X           X        X     X     X        X  X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X                    X           X     X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X  X  X     X        X     X     X  X     X  X     X     X|             
      Osteosarcoma, Metastatic, Bone       |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X                                   X           X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |       X                                                                  |             
      Leukemia Mononuclear                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |                                              X                           |             
      Squamous Cell Papilloma              |                                                          X        X      |             
      Subcutaneous Tissue, Fibroma         |                      X                                                   |             
      Subcutaneous Tissue, Fibrosarcoma    |       X                                                                  |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Chordoma                             |                                                                          |             
      Osteosarcoma                         |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +     +                  |             
      Leukemia Mononuclear                 |                                                 X                        |             
      Osteosarcoma, Metastatic, Bone       |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                 +                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   4                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 7| 8| 0| 8| 8| 7| 9| 3| 7| 9| 5| 8| 4| 7| 9| 5| 9| 8| 8| 7| 9| 8| 5| 7|             
                             DAY ON TEST   | 0| 0| 1| 3| 0| 4| 1| 1| 2| 1| 1| 9| 7| 4| 7| 1| 5| 1| 2| 4| 5| 1| 1| 7| 5|             
                                           | 9| 4| 6| 8| 9| 7| 7| 0| 7| 6| 0| 4| 5| 5| 0| 0| 6| 0| 6| 0| 8| 0| 6| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                    X                     |             
      Leukemia Mononuclear                 | X           X  X  X        X        X     X     X        X  X     X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Eye                                     | +                 +                                            +         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X     X                 X     X                 X            |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                          +               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 | X           X  X  X  X     X        X     X     X  X     X  X     X     X|             
      Mesothelioma Malignant               |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             

                                                             Page   5                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9|  |            |
                             DAY ON TEST   | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0|  |            |
                                           | 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |     A      |
    0 MG/KG                                | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|  |     L      |
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Chordoma, Metastatic, Bone           |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Hepatocellular Adenoma               |                               X                                          |          3 |
      Leukemia Mononuclear                 |       X     X     X  X  X           X  X     X  X        X               |         24 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                             +  +           +        +        +  +   |  14        |
      Leukemia Mononuclear                 |                                                          X               |          3 |
      Mesothelioma Malignant               |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                          X     X                           |          7 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
      Acinar Cell, Adenoma                 |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Squamous Cell Papilloma              |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X           X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                                X                           |          4 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   6                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9|  |            |
                             DAY ON TEST   | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0|  |            |
                                           | 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |     A      |
    0 MG/KG                                | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|  |     L      |
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Adenoma                              |                   X                                                      |          1 |
      Leukemia Mononuclear                 |             X        X              X        X                           |         12 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +   |  48        |
      Leukemia Mononuclear                 |             X        X                       X                           |          9 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |    X  X     X     X     X                 X     X     X                  |         10 |
      Bilateral, Pheochromocytoma Benign   | X              X                                                         |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Adenoma                              |                         X                                         X      |          4 |
      Carcinoma                            | X                 X        X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                                X           X               |          7 |
      Pars Distalis, Adenoma               |                   X                 X                       X  X  X  X   |         14 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      C-Cell, Adenoma                      | X                          X                    X     X                  |          6 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Adenoma                              |                   X                                                  X   |          2 |
      Carcinoma                            | X     X                                         X                        |          4 |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   7                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9|  |            |
                             DAY ON TEST   | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0|  |            |
                                           | 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |     A      |
    0 MG/KG                                | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|  |     L      |
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |             X                                X                           |          2 |
      Bilateral, Interstitial Cell, Adenoma| X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X     X   |         39 |
      Interstitial Cell, Adenoma           |                                                                   X      |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |       X     X     X  X  X           X  X     X           X               |         21 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +     +  +  +           +  +           +                     |  20        |
      Axillary, Leukemia Mononuclear       |             X                                                            |          1 |
      Deep Cervical, Leukemia Mononuclear  |             X                                                            |          1 |
      Iliac, Leukemia Mononuclear          |             X                                                            |          1 |
      Mediastinal, Leukemia Mononuclear    |                   X     X           X                                    |         10 |
      Mediastinal, Osteosarcoma,           |                                                                          |            |
          Metastatic, Bone                 |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |             X        X              X  X                                 |          8 |
      Renal, Leukemia Mononuclear          |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Leukemia Mononuclear                 |       X     X                       X  X     X           X               |         14 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X        X                 X     X           X               |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X     X  X  X           X  X     X  X        X               |         23 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +   |  44        |
      Leukemia Mononuclear                 |             X                                X           X               |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Fibroadenoma                         |                                                       X                  |          2 |
      Leukemia Mononuclear                 |             X                                X                           |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Basal Cell Carcinoma                 |                                                 X                        |          1 |
      Keratoacanthoma                      |                                                       X                  |          2 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         | X                                      X                       X     X   |          5 |
      Subcutaneous Tissue, Fibrosarcoma    | X                                                     X                  |          3 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   8                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9|  |            |
                             DAY ON TEST   | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0|  |            |
                                           | 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |     A      |
    0 MG/KG                                | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|  |     L      |
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Chordoma                             |                                  X                                       |          1 |
      Osteosarcoma                         |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Osteosarcoma, Metastatic, Bone       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |                                        X     X                           |          3 |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                  +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                  +                                       |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |          1 |
      Alveolar/Bronchiolar Carcinoma       |    X                                      X                              |          2 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Leukemia Mononuclear                 |       X     X     X  X  X           X  X     X           X               |         20 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |          +                                            +                  |   2        |
      Carcinoma                            |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X     X  X              X        X           X               |         12 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                +         |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Leukemia Mononuclear                 |       X     X     X  X  X           X  X     X  X        X               |         24 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page   9                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 9| 6| 8| 9| 8| 8| 7| 7| 8| 7| 7| 6| 9| 6| 8| 4| 9| 8| 7| 9| 6| 9|  |            |
                             DAY ON TEST   | 6| 6| 1| 5| 6| 1| 9| 1| 9| 6| 8| 9| 5| 9| 1| 2| 9| 6| 1| 1| 8| 1| 6| 0|  |            |
                                           | 9| 9| 0| 9| 8| 0| 7| 6| 9| 3| 3| 4| 2| 0| 0| 3| 7| 2| 0| 5| 0| 0| 0| 0|  |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |     A      |
    0 MG/KG                                | 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|  |     L      |
                                           | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  10                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 8| 5| 9| 9| 9| 7| 6| 8| 9| 9| 9| 9| 7| 9| 1| 9| 7| 5| 9| 9| 9| 9| 9| 8|             
                             DAY ON TEST   | 1| 4| 7| 1| 1| 1| 9| 3| 3| 1| 1| 1| 1| 5| 1| 2| 1| 9| 7| 1| 1| 1| 1| 1| 2|             
                                           | 0| 0| 4| 0| 0| 0| 0| 4| 2| 0| 0| 0| 0| 0| 0| 0| 0| 5| 1| 0| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    337.5                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Histiocytic Sarcoma                  |                   X                                                      |             
      Leukemia Mononuclear                 |    X                    X                                X               |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +     +           +                       +        +               |             
      Leukemia Mononuclear                 |                         X                                                |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Spleen                          |                   X                                                      |             
      Leukemia Mononuclear                 |                         X                                                |             
      Acinar Cell, Adenoma                 |                               X                    X        X     X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Parotid Gland, Fibrosarcoma          |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Pheochromocytoma Malignant           |                                           X                              |             
      Pheochromocytoma Benign              |                X                          X                 X            |             
      Bilateral, Pheochromocytoma Benign   | X                                                                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                            X        X                             X      |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  11                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 8| 5| 9| 9| 9| 7| 6| 8| 9| 9| 9| 9| 7| 9| 1| 9| 7| 5| 9| 9| 9| 9| 9| 8|             
                             DAY ON TEST   | 1| 4| 7| 1| 1| 1| 9| 3| 3| 1| 1| 1| 1| 5| 1| 2| 1| 9| 7| 1| 1| 1| 1| 1| 2|             
                                           | 0| 0| 4| 0| 0| 0| 0| 4| 2| 0| 0| 0| 0| 0| 0| 0| 0| 5| 1| 0| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    337.5                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |       X     X              X  X     X                    X        X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Bilateral, C-Cell, Carcinoma         |             X                                                            |             
      C-Cell, Adenoma                      |                                        X           X  X                  |             
      C-Cell, Carcinoma                    |                                        X                                 |             
      Follicular Cell, Adenoma             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                   X      |             
      Carcinoma                            | X                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma|    X     X  X  X     X  X  X  X  X  X  X        X  X  X  X  X  X  X  X   |             
      Interstitial Cell, Adenoma           | X                 X                       X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +     +     +  +                 +           +               |             
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |             
           Thyroid Gland                   |             X                                                            |             
      Mediastinal, Fibrous Histiocytoma,   |                                                                          |             
           Metastatic, Skin                |                                                                          |             
      Mediastinal, Histiocytic Sarcoma,    |                                                                          |             
           Metastatic, Spleen              |                   X                                                      |             
      Mediastinal, Leukemia Mononuclear    |    X                    X                                X               |             
      Pancreatic, Leukemia Mononuclear     |    X                                                                     |             
      Renal, Fibrous Histiocytoma,         |                                                                          |             
          Metastatic, Skin                 |                                                                          |             
      Renal, Histiocytic Sarcoma,          |                                                                          |             
          Metastatic, Spleen               |                   X                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  12                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 8| 5| 9| 9| 9| 7| 6| 8| 9| 9| 9| 9| 7| 9| 1| 9| 7| 5| 9| 9| 9| 9| 9| 8|             
                             DAY ON TEST   | 1| 4| 7| 1| 1| 1| 9| 3| 3| 1| 1| 1| 1| 5| 1| 2| 1| 9| 7| 1| 1| 1| 1| 1| 2|             
                                           | 0| 0| 4| 0| 0| 0| 0| 4| 2| 0| 0| 0| 0| 0| 0| 0| 0| 5| 1| 0| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    337.5                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X                    X                                X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  I  I  M|             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |                                                          X               |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      | X                                                                        |             
      Squamous Cell Papilloma              |                            X                                   X         |             
      Trichoepithelioma                    |                                           X                              |             
      Subcutaneous Tissue, Fibroma         |    X                                                                     |             
      Subcutaneous Tissue, Fibrous         |                                                                          |             
          Histiocytoma                     |                                                                          |             
      Subcutaneous Tissue, Schwannoma NOS  |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteosarcoma                         |                                                    X                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Leukemia Mononuclear                 |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Oligodendroglioma Malignant          |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Carcinoma, Metastatic, Thyroid Gland |                                        X                                 |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                                                          |             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Spleen                          |                   X                                                      |             
      Leukemia Mononuclear                 |    X                    X                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Carcinoma, Metastatic, Thyroid Gland |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  13                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 9| 8| 5| 9| 9| 9| 7| 6| 8| 9| 9| 9| 9| 7| 9| 1| 9| 7| 5| 9| 9| 9| 9| 9| 8|             
                             DAY ON TEST   | 1| 4| 7| 1| 1| 1| 9| 3| 3| 1| 1| 1| 1| 5| 1| 2| 1| 9| 7| 1| 1| 1| 1| 1| 2|             
                                           | 0| 0| 4| 0| 0| 0| 0| 4| 2| 0| 0| 0| 0| 0| 0| 0| 0| 5| 1| 0| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    337.5                                  | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +        +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma, Metastatic,     |                                                                          |             
           Spleen                          |                   X                                                      |             
      Leukemia Mononuclear                 |    X                    X                                                |             
                                            __________________________________________________________________________|             
   Ureter                                  |                +                                                         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                     +                    +               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Papilloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                   X                                                      |             
      Leukemia Mononuclear                 |    X                    X                                X               |             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             

                                                             Page  14                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 9| 6| 8| 9| 7| 9| 9| 9| 5| 9| 1| 8| 8| 9| 8| 8| 8| 7| 2| 9| 9| 8| 8| 4|            |
                             DAY ON TEST   | 1| 1| 9| 4| 1| 3| 1| 1| 1| 7| 1| 9| 5| 7| 1| 8| 7| 7| 9| 0| 1| 1| 1| 7| 3|            |
                                           | 6| 0| 5| 5| 0| 7| 0| 0| 0| 3| 0| 9| 4| 5| 0| 9| 5| 8| 3| 0| 0| 0| 2| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    337.5                                  | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 9|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                    X                     |          1 |
      Hepatocellular Carcinoma             |                                     X                                    |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X                             X                                X        X|          7 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +              +                                      +              +   |  10        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                X                                      X              X   |          4 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Spleen                          |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Acinar Cell, Adenoma                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parotid Gland, Fibrosarcoma          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                      +   |   1        |
      Squamous Cell Papilloma              |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                                                                       X|          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  15                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 9| 6| 8| 9| 7| 9| 9| 9| 5| 9| 1| 8| 8| 9| 8| 8| 8| 7| 2| 9| 9| 8| 8| 4|            |
                             DAY ON TEST   | 1| 1| 9| 4| 1| 3| 1| 1| 1| 7| 1| 9| 5| 7| 1| 8| 7| 7| 9| 0| 1| 1| 1| 7| 3|            |
                                           | 6| 0| 5| 5| 0| 7| 0| 0| 0| 3| 0| 9| 4| 5| 0| 9| 5| 8| 3| 0| 0| 0| 2| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    337.5                                  | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 9|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              |                               X           X                       X      |          6 |
      Bilateral, Pheochromocytoma Benign   |                                                                X         |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Adenoma                              |                                                             X            |          4 |
      Carcinoma                            |                                                                X  X      |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  49        |
      Pars Distalis, Adenoma               | X     X                    X  X                                          |         12 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, C-Cell, Carcinoma         |                                                                          |          1 |
      C-Cell, Adenoma                      |                X                          X                              |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Interstitial Cell, Adenoma|    X     X  X  X  X  X  X     X        X  X  X  X  X  X     X  X  X  X   |         37 |
      Interstitial Cell, Adenoma           | X                                                                       X|          5 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                    +  +              +   |  10        |
      Deep Cervical, Carcinoma, Metastatic,|                                                                          |            |
           Thyroid Gland                   |                                                                          |          1 |
      Mediastinal, Fibrous Histiocytoma,   |                                                                          |            |
           Metastatic, Skin                |                                                    X                     |          1 |
      Mediastinal, Histiocytic Sarcoma,    |                                                                          |            |
           Metastatic, Spleen              |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  16                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 9| 6| 8| 9| 7| 9| 9| 9| 5| 9| 1| 8| 8| 9| 8| 8| 8| 7| 2| 9| 9| 8| 8| 4|            |
                             DAY ON TEST   | 1| 1| 9| 4| 1| 3| 1| 1| 1| 7| 1| 9| 5| 7| 1| 8| 7| 7| 9| 0| 1| 1| 1| 7| 3|            |
                                           | 6| 0| 5| 5| 0| 7| 0| 0| 0| 3| 0| 9| 4| 5| 0| 9| 5| 8| 3| 0| 0| 0| 2| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    337.5                                  | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 9|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Fibrous Histiocytoma,         |                                                                          |            |
          Metastatic, Skin                 |                                                    X                     |          1 |
      Renal, Histiocytic Sarcoma,          |                                                                          |            |
          Metastatic, Spleen               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X              X                                                        X|          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +|  40        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Carcinoma                            |                   X                                                      |          1 |
      Fibroadenoma                         |                               X                                          |          2 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Keratoacanthoma                      |                                                                          |          1 |
      Squamous Cell Papilloma              |             X                                                            |          3 |
      Trichoepithelioma                    |                                              X                           |          2 |
      Subcutaneous Tissue, Fibroma         |             X  X  X                             X                        |          5 |
      Subcutaneous Tissue, Fibrous         |                                                                          |            |
          Histiocytoma                     |                                  X                 X                     |          2 |
      Subcutaneous Tissue, Schwannoma NOS  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Osteosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                    +                     |   2        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                    X                     |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  17                                                               
NTP Experiment-Test: 05099-09                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 04/17/95  
Route: GAVAGE                                                                                                     Time: 16:39:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 9| 6| 8| 9| 7| 9| 9| 9| 5| 9| 1| 8| 8| 9| 8| 8| 8| 7| 2| 9| 9| 8| 8| 4|            |
                             DAY ON TEST   | 1| 1| 9| 4| 1| 3| 1| 1| 1| 7| 1| 9| 5| 7| 1| 8| 7| 7| 9| 0| 1| 1| 1| 7| 3|            |
                                           | 6| 0| 5| 5| 0| 7| 0| 0| 0| 3| 0| 9| 4| 5| 0| 9| 5| 8| 3| 0| 0| 0| 2| 7| 0|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|     A      |
    337.5                                  | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|     L      |
    MG/KG                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 9|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                         X|          1 |
      Oligodendroglioma Malignant          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                    X                     |          1 |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Spleen                          |                                                                          |          1 |
      Leukemia Mononuclear                 | X                                                                       X|          4 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma, Metastatic,     |                                                                          |            |
           Spleen                          |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                         X|          3 |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Papilloma                            |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 | X              X              X                                X        X|          8 |
      Mesothelioma Malignant               |                X                                      X              X   |          4 |
 __________________________________________________________________________________________________________________________________ 

                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

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