TDMS Study 05099-10 Pathology Tables
NEOPLASMS BY INDIVIDUAL ANIMAL
SALICYLAZOSULFAPYRIDINE
NTP Experiment-Test: 05099-10 Report: PEIRPT04
Study Type: CHRONIC Date: 03/20/95
Route: GAVAGE Time: 17:10:59
RESTRICTED 157 WEEK CORE
Facility: Southern Research Institute
Chemical CAS #: 599-79-1
Lock Date: 08/26/92
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG
Include 002 2700 MG/KG
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
_____________________________________________________________________________________________________________________
| 0| 8| 9| 9| 7| 8| 0| 7| 7| 0| 0| 5| 7| 8| 5| 8| 9| 0| 5| 9| 7| 0| 0| 8| 0|
DAY ON TEST | 9| 8| 2| 5| 2| 1| 9| 6| 9| 9| 9| 6| 4| 5| 5| 1| 0| 9| 9| 4| 1| 0| 9| 6| 9|
| 3| 5| 1| 0| 8| 2| 3| 3| 6| 3| 3| 9| 3| 8| 5| 7| 5| 3| 7| 3| 8| 9| 3| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 MG/KG | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Stomach, | |
Glandular | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Adenocarcinoma | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoid Tumor Malignant, | |
Metastatic, Stomach, Glandular | X |
Hemangiosarcoma | X X|
Hepatocellular Carcinoma | X X X X X X |
Hepatocellular Carcinoma, Multiple | X X X |
Hepatocellular Adenoma | X X X X X |
Hepatocellular Adenoma, Multiple | |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Mesentery | + + + |
Carcinoma, Metastatic, Kidney | X |
Leiomyosarcoma, Metastatic, Stomach, | |
Glandular | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Leiomyosarcoma, Metastatic, Stomach, | |
Glandular | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Stomach, | |
Glandular | |
Lymphoma Malignant | X |
Squamous Cell Papilloma | X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
Adenoma | |
Carcinoid Tumor Malignant | X |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
_____________________________________________________________________________________________________________________
| 0| 8| 9| 9| 7| 8| 0| 7| 7| 0| 0| 5| 7| 8| 5| 8| 9| 0| 5| 9| 7| 0| 0| 8| 0|
DAY ON TEST | 9| 8| 2| 5| 2| 1| 9| 6| 9| 9| 9| 6| 4| 5| 5| 1| 0| 9| 9| 4| 1| 0| 9| 6| 9|
| 3| 5| 1| 0| 8| 2| 3| 3| 6| 3| 3| 9| 3| 8| 5| 7| 5| 3| 7| 3| 8| 9| 3| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 MG/KG | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Leiomyosarcoma | |
Lymphoma Malignant | X |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Stomach, | |
Glandular | |
Lymphoma Malignant | X |
Spindle Cell, Adenoma | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + M + + + + + + + + + + + + + + + M + M|
Pars Distalis, Adenoma | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Adenoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Interstitial Cell, Adenoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node | + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
_____________________________________________________________________________________________________________________
| 0| 8| 9| 9| 7| 8| 0| 7| 7| 0| 0| 5| 7| 8| 5| 8| 9| 0| 5| 9| 7| 0| 0| 8| 0|
DAY ON TEST | 9| 8| 2| 5| 2| 1| 9| 6| 9| 9| 9| 6| 4| 5| 5| 1| 0| 9| 9| 4| 1| 0| 9| 6| 9|
| 3| 5| 1| 0| 8| 2| 3| 3| 6| 3| 3| 9| 3| 8| 5| 7| 5| 3| 7| 3| 8| 9| 3| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 MG/KG | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Bronchial, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | X X |
Mediastinal, Carcinoma, Metastatic, | |
Kidney | X |
Mediastinal, Lymphoma Malignant | X X |
Pancreatic, Lymphoma Malignant | X |
Renal, Leiomyosarcoma, Metastatic, | |
Stomach, Glandular | |
Renal, Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +|
Carcinoma, Metastatic, Harderian | |
Gland | |
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Thymus | + + + + + + M M + + + M + + + + + + + + + + + + +|
Carcinoma, Metastatic, Kidney | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Hemangioma | |
Subcutaneous Tissue, Lipoma | |
Subcutaneous Tissue, Lymphoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skeletal Muscle | |
Hemangiosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X X X X X X X X |
Carcinoma, Metastatic, Harderian | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
_____________________________________________________________________________________________________________________
| 0| 8| 9| 9| 7| 8| 0| 7| 7| 0| 0| 5| 7| 8| 5| 8| 9| 0| 5| 9| 7| 0| 0| 8| 0|
DAY ON TEST | 9| 8| 2| 5| 2| 1| 9| 6| 9| 9| 9| 6| 4| 5| 5| 1| 0| 9| 9| 4| 1| 0| 9| 6| 9|
| 3| 5| 1| 0| 8| 2| 3| 3| 6| 3| 3| 9| 3| 8| 5| 7| 5| 3| 7| 3| 8| 9| 3| 2| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0 MG/KG | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|
| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Gland | X |
Carcinoma, Metastatic, Kidney | X |
Hepatocellular Carcinoma, Metastatic,| |
Liver | X |
Histiocytic Sarcoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
__________________________________________________________________________|
Harderian Gland | + + +|
Adenoma | X X|
Carcinoma | X |
__________________________________________________________________________|
Zymbal's Gland | + |
Carcinoma | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma, Metastatic, Stomach, | |
Glandular | |
Lymphoma Malignant | X X |
Cortex, Adenoma | X |
Cortex, Carcinoma | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Histiocytic Sarcoma | X |
Lymphoma Malignant | X X X X |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
__________________________________________________________________________________________________________________________________
| 8| 0| 7| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 8| 0| 9| 0| 0| 9| 4| | |
DAY ON TEST | 1| 9| 5| 9| 7| 9| 9| 9| 7| 9| 9| 9| 9| 9| 6| 5| 7| 9| 6| 9| 9| 4| 4| | |
| 0| 3| 0| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 3| 3| 2| 3| 3| 3| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Glandular | X | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenocarcinoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoid Tumor Malignant, | | |
Metastatic, Stomach, Glandular | | 1 |
Hemangiosarcoma | | 2 |
Hepatocellular Carcinoma | X X X X X X X | 13 |
Hepatocellular Carcinoma, Multiple | | 3 |
Hepatocellular Adenoma | X X X X | 9 |
Hepatocellular Adenoma, Multiple | X | 1 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 3 |
__________________________________________________________________________|____________|
Mesentery | + + + + | 7 |
Carcinoma, Metastatic, Kidney | | 1 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Glandular | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Carcinoma, Metastatic, Kidney | | 1 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Glandular | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Glandular | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
__________________________________________________________________________________________________________________________________
| 8| 0| 7| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 8| 0| 9| 0| 0| 9| 4| | |
DAY ON TEST | 1| 9| 5| 9| 7| 9| 9| 9| 7| 9| 9| 9| 9| 9| 6| 5| 7| 9| 6| 9| 9| 4| 4| | |
| 0| 3| 0| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 3| 3| 2| 3| 3| 3| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Papilloma | X | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Adenoma | X | 1 |
Carcinoid Tumor Malignant | | 1 |
Carcinoma | | 1 |
Leiomyosarcoma | X | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | + + + + | 8 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + M + + + + + + + + + | 47 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Glandular | X | 1 |
Lymphoma Malignant | | 1 |
Spindle Cell, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + M + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + | 44 |
Pars Distalis, Adenoma | X | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Follicular Cell, Adenoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
__________________________________________________________________________________________________________________________________
| 8| 0| 7| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 8| 0| 9| 0| 0| 9| 4| | |
DAY ON TEST | 1| 9| 5| 9| 7| 9| 9| 9| 7| 9| 9| 9| 9| 9| 6| 5| 7| 9| 6| 9| 9| 4| 4| | |
| 0| 3| 0| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 3| 3| 2| 3| 3| 3| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant | | 1 |
Interstitial Cell, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 15 |
Bronchial, Lymphoma Malignant | | 1 |
Inguinal, Lymphoma Malignant | | 2 |
Mediastinal, Carcinoma, Metastatic, | | |
Kidney | | 1 |
Mediastinal, Lymphoma Malignant | | 2 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Leiomyosarcoma, Metastatic, | | |
Stomach, Glandular | X | 1 |
Renal, Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + | 47 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 4 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 4 |
__________________________________________________________________________|____________|
Thymus | + M + + M + + + M + + + + + + + + + + + I + + | 41 |
Carcinoma, Metastatic, Kidney | | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Subcutaneous Tissue, Hemangioma | X | 1 |
Subcutaneous Tissue, Lipoma | X | 1 |
Subcutaneous Tissue, Lymphoma | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
__________________________________________________________________________________________________________________________________
| 8| 0| 7| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 8| 0| 9| 0| 0| 9| 4| | |
DAY ON TEST | 1| 9| 5| 9| 7| 9| 9| 9| 7| 9| 9| 9| 9| 9| 6| 5| 7| 9| 6| 9| 9| 4| 4| | |
| 0| 3| 0| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 3| 3| 2| 3| 3| 3| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Hemangiosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Alveolar/Bronchiolar Adenoma | X X X X | 8 |
Alveolar/Bronchiolar Carcinoma | X X X X X | 13 |
Carcinoma, Metastatic, Harderian | | |
Gland | X | 2 |
Carcinoma, Metastatic, Kidney | | 1 |
Hepatocellular Carcinoma, Metastatic,| | |
Liver | X | 2 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 8 |
Adenoma | X X X X | 6 |
Carcinoma | X | 2 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Leiomyosarcoma, Metastatic, Stomach, | | |
Glandular | X | 1 |
Lymphoma Malignant | | 2 |
Cortex, Adenoma | | 1 |
Cortex, Carcinoma | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
__________________________________________________________________________________________________________________________________
| 8| 0| 7| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 8| 0| 9| 0| 0| 9| 4| | |
DAY ON TEST | 1| 9| 5| 9| 7| 9| 9| 9| 7| 9| 9| 9| 9| 9| 6| 5| 7| 9| 6| 9| 9| 4| 4| | |
| 0| 3| 0| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 4| 2| 3| 3| 2| 3| 3| 3| 5| | |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0 MG/KG | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 2| | |
__________________________________________________________________________________________________________________________________
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + | 48 |
Histiocytic Sarcoma | | 1 |
Lymphoma Malignant | X | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 3| 0| 0| 0| 7| 0| 0| 6| 0| 0| 0| 0| 9| 0| 0| 0| 8| 0| 0| 0| 0|
DAY ON TEST | 9| 9| 9| 9| 1| 9| 9| 9| 1| 9| 9| 0| 9| 9| 9| 9| 0| 4| 4| 4| 8| 9| 9| 9| 9|
| 3| 3| 3| 3| 4| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3| 8| 8| 0| 5| 6| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2700 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Lymphoma Malignant | X |
Lymphoid Tissue, Leiomyoma | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X |
Lymphoma Malignant | X X X X X |
__________________________________________________________________________|
Mesentery | + |
Fat, Hemangioma | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant | X |
Squamous Cell Papilloma | X X |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Adenoma | X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 3| 0| 0| 0| 7| 0| 0| 6| 0| 0| 0| 0| 9| 0| 0| 0| 8| 0| 0| 0| 0|
DAY ON TEST | 9| 9| 9| 9| 1| 9| 9| 9| 1| 9| 9| 0| 9| 9| 9| 9| 0| 4| 4| 4| 8| 9| 9| 9| 9|
| 3| 3| 3| 3| 4| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3| 8| 8| 0| 5| 6| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2700 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Pituitary Gland | + + + + + I + + + + + + + + + + + + + M + + + + +|
Pars Distalis, Adenoma | X |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Penis | + |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Axillary, Lymphoma Malignant | X |
Iliac, Lymphoma Malignant | X |
Inguinal, Lymphoma Malignant | X X |
Mediastinal, Lymphoma Malignant | X X |
Pancreatic, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X X X |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Lymphoma Malignant | X X |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | |
Lymphoma Malignant | X X X X |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + M M M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Lymphoma | |
Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 3| 0| 0| 0| 7| 0| 0| 6| 0| 0| 0| 0| 9| 0| 0| 0| 8| 0| 0| 0| 0|
DAY ON TEST | 9| 9| 9| 9| 1| 9| 9| 9| 1| 9| 9| 0| 9| 9| 9| 9| 0| 4| 4| 4| 8| 9| 9| 9| 9|
| 3| 3| 3| 3| 4| 3| 3| 3| 9| 3| 3| 5| 3| 3| 3| 3| 8| 8| 0| 5| 6| 3| 3| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
2700 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma | X X X |
Lymphoma Malignant | X |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Pleura | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
Adenoma | |
__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X X X X X X X |
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
__________________________________________________________________________________________________________________________________
| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 9| 7| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| |
DAY ON TEST | 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 5| 3| 2| 9| 9| 9| 7| 9| 4| 4| 9| 9| 7| 9| 9| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 8| 3| 6| 6| 3| 3| 6| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2700 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + A + + + + + + + +| 47 |
Lymphoma Malignant | | 1 |
Lymphoid Tissue, Leiomyoma | X | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + A + + + + + A + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + A + + + + + A + + + + + + + +| 46 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A + + + + + + + +| 47 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hepatocellular Carcinoma | X X X X X X | 6 |
Hepatocellular Adenoma | X X X X X X | 9 |
Hepatocellular Adenoma, Multiple | X X X | 5 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Hemangioma | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
Lymphoma Malignant | | 1 |
Squamous Cell Papilloma | | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + A + + + + + + + + + + + + + +| 48 |
Adenoma | | 1 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Tooth | + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
__________________________________________________________________________________________________________________________________
| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 9| 7| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| |
DAY ON TEST | 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 5| 3| 2| 9| 9| 9| 7| 9| 4| 4| 9| 9| 7| 9| 9| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 8| 3| 6| 6| 3| 3| 6| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2700 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Pheochromocytoma Benign | X | 1 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Adenoma | | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Penis | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 3 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + | 17 |
Axillary, Lymphoma Malignant | | 1 |
Iliac, Lymphoma Malignant | | 1 |
Inguinal, Lymphoma Malignant | | 2 |
Mediastinal, Lymphoma Malignant | X | 3 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant | X | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 6 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
__________________________________________________________________________________________________________________________________
| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 9| 7| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| |
DAY ON TEST | 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 5| 3| 2| 9| 9| 9| 7| 9| 4| 4| 9| 9| 7| 9| 9| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 8| 3| 6| 6| 3| 3| 6| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2700 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemangioma | X | 1 |
Lymphoma Malignant | X | 5 |
__________________________________________________________________________|____________|
Thymus | M + + + + + + + + M + + + + + M M + + + + + M + +| 42 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Subcutaneous Tissue, Lymphoma | | |
Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar/Bronchiolar Adenoma | X X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X | 2 |
Alveolar/Bronchiolar Carcinoma | X X X | 6 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________|____________|
Pleura | + | 1 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Adenoma | X | 1 |
__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05099-10 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC SALICYLAZOSULFAPYRIDINE Date: 03/20/95
Route: GAVAGE Time: 17:10:59
__________________________________________________________________________________________________________________________________
| 0| 0| 8| 0| 0| 0| 0| 0| 0| 0| 0| 9| 7| 0| 0| 0| 0| 0| 0| 6| 0| 0| 0| 0| 0| |
DAY ON TEST | 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 5| 3| 2| 9| 9| 9| 7| 9| 4| 4| 9| 9| 7| 9| 9| |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 3| 8| 3| 6| 6| 3| 3| 6| 3| 3| |
_____________________________________________________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
2700 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L |
MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant | X | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------