National Toxicology Program

National Toxicology Program
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TDMS Study 05099-99 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: SOUTHERN RESEARCH INST                                    DATE: 05/08/95   
EXP: 05099                 SALICYLAZOSULFAPYRIDINE             TIME: 12:01:01   
TEST: 99              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 61552B   
CONT: N01-ES-85233                                             CAS: 599-79-1    
PATHOLOGIST: R.B. THOMPSON                                                      
--------------------------------------------------------------------------------
                                                                                
                       05099/08 -VS- 05099/10 COMPARISON                        
                                                                                

REASONS FOR REMOVAL:                                                            
                                                                                
25022 Accidently Killed                                                         
25018 Dosing Accident                                                           
25005 Interval Sacrifice                                                        
25019 Moribund Sacrifice                                                        
25020 Natural Death                                                             
25017 Scheduled Sacrifice                                                       
25021 Terminal Sacrifice                                                        
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             

ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE 001    0 MG/KG                                                          
INCLUDE 004    RTD     0 MG/KG                                                  
NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: SOUTHERN RESEARCH INST                                    DATE: 05/08/95  
EXP: 05099                 SALICYLAZOSULFAPYRIDINE             TIME: 12:01:01  
TEST: 99              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 61552B  
CONT: N01-ES-85233                                             CAS: 599-79-1   
PATHOLOGIST: R.B. THOMPSON                                                     
                              SALICYLAZOSULFAPYRIDINE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 MG/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 8      CENSORED DEATHS 12   TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      420   420   610   611   658   662   666   689                             |
 |  CENSORED DEATHS                                                               |
 |      150   351   456   456   456   456   456   456   456   456                 |
 |      456   456                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = RTD     0 MG/KG                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 62     UNCENSORED DEATHS 10     CENSORED DEATHS 10   TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      495   603   616   632   647   660   661   717   722   723                 |
 |  CENSORED DEATHS                                                               |
 |      457   457   457   457   457   457   457   457   457   457                 |
 |                                                                                |
 ==================================================================================
                              SALICYLAZOSULFAPYRIDINE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 728 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   728 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 MG/KG    |   100.0 100.0 100.0 100.0  96.6  96.6  96.6  96.6  88.2  84.0      |
 |           |                                                                    |
 |           |                                                                    |
 |RTD        |   100.0 100.0 100.0 100.0 100.0 100.0  98.1  96.2  86.5  80.8      |
 |0 MG/KG    |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                        DOSE                    |
 |                                                                                |
 |                                0 MG/KG                   RTD                   |
 |                                                          0 MG/KG               |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       84.0%                     80.8%                 |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |        -----                     -----                |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       592.0                     647.6                 |
 |NATURAL DEATHS (C)      |       (38.7)                    (21.8)                |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       648.6                     671.3                 |
 |(STANDARD ERROR)        |       (17.4)                    (13.0)                |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                      SALICYLAZOSULFAPYRIDINE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 MG/KG          = 1
                                                        RTD     0 MG/KG  = 2

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                                 1           2
      |
      |
      |
   98 +                                                                               2                 2
      |
      |
      |                                                                   1                              1
   96 +                                                                                                 22
      |
      |
      |
P  94 +                                                                                                  2  2
E     |
R     |
C     |                                                                                                  1  2 21
E  92 +
N     |
T     |
      |                                                                                                       21 1
S  90 +
U     |
R     |
V     |
I  88 +                                                                                                          11
V     |
A     |
L     |                                                                                                          2       2
   86 +                                                                                                           1  1
      |
      |
      |                                                                                                                  22
   84 +                                                                                                              1    1
      |
      |
      |
   82 +
      |
      |                                                                                                                   2
      |
   80 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 2 obs hidden.
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