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TDMS Study 05099-98 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                      SALICYLAZOSULFAPYRIDINE


NTP Experiment-Test: 05099-98                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 05/10/95
Route: GAVAGE                                                                                                     Time: 11:56:50


                                               05099/07 -VS- 05099/09 COMPARISON


       Facility:  SOUTHERN RESEARCH INSTITUTE

       Chemical CAS #:  599-79-1

       Lock Date:  02/03/93

       Cage Range:  All

       Reasons For Removal:    25004 Dead                              25018 Dosing Accident
                               25014 Gavage Death                      25005 Interval Sacrifice
                               25003 Moribund                          25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/KG AD LIB
                               Include 004    0 MG/KG RTD



























a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05099-98  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 05/10/95  
Route: GAVAGE                                                                                                     Time: 11:56:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG                                                             
                                                   AD LIB       RTD                                                                 
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DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70          110                                                               

  Scheduled Sacrifice                                              33                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13                                                                            
    Natural Death                                      1                                                                            
    Dosing Accident                                    1                                                                            
    Gavage Death                                                    2                                                               
    Moribund                                                       13                                                               
    Dead                                                            2                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                35                                                                            

  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (50)         (50)                                                             
      Adenoma                                                       1 (2%)                                                          
   Intestine Small, Ileum                             (49)         (49)                                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)                                                             
      Hepatocellular Adenoma                           2 (4%)       1 (2%)                                                          
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                  1 (2%)                                                                       
   Mesentery                                          (17)         (20)                                                             
      Fibrous Histiocytoma                             1 (6%)                                                                       
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                  1 (6%)                                                                       
   Pancreas                                           (50)         (50)                                                             
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                  1 (2%)                                                                       
      Acinar Cell, Adenoma                             9 (18%)      5 (10%)                                                         
      Acinar Cell, Adenoma, Multiple                   3 (6%)                                                                       
      Acinar Cell, Carcinoma, Multiple                 1 (2%)                                                                       
   Pharynx                                                         (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
   Stomach, Forestomach                               (50)         (50)                                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)       1 (2%)                                                          
   Tongue                                                          (2)                                                              
      Squamous Cell Carcinoma                                       1 (50%)                                                         
      Squamous Cell Papilloma                                       1 (50%)                                                         

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NTP Experiment-Test: 05099-98  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 05/10/95  
Route: GAVAGE                                                                                                     Time: 11:56:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG                                                             
                                                   AD LIB       RTD                                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
      Schwannoma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)                                                             
      Adenoma                                                       1 (2%)                                                          
   Adrenal Medulla                                    (50)         (50)                                                             
      Pheochromocytoma Malignant                                    2 (4%)                                                          
      Pheochromocytoma Complex                         1 (2%)                                                                       
      Pheochromocytoma Benign                         12 (24%)      5 (10%)                                                         
      Bilateral, Pheochromocytoma Benign               3 (6%)       3 (6%)                                                          
   Islets, Pancreatic                                 (50)         (50)                                                             
      Adenoma                                          2 (4%)       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (50)         (50)                                                             
      Ganglioneuroma                                   1 (2%)                                                                       
      Pars Distalis, Adenoma                          14 (28%)     13 (26%)                                                         
   Thyroid Gland                                      (50)         (49)                                                             
      C-Cell, Adenoma                                  3 (6%)       4 (8%)                                                          
      C-Cell, Carcinoma                                2 (4%)                                                                       
      Follicular Cell, Adenoma                         4 (8%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
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 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)                                                             
   Preputial Gland                                    (50)         (50)                                                             
      Adenoma                                          1 (2%)       3 (6%)                                                          
      Carcinoma                                        2 (4%)                                                                       
   Testes                                             (50)         (50)                                                             
      Bilateral, Interstitial Cell, Adenoma           44 (88%)     38 (76%)                                                         
      Interstitial Cell, Adenoma                       1 (2%)       6 (12%)                                                         
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NTP Experiment-Test: 05099-98  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 05/10/95  
Route: GAVAGE                                                                                                     Time: 11:56:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG                                                             
                                                   AD LIB       RTD                                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)                                                             
   Lymph Node                                         (9)          (11)                                                             
   Lymph Node, Mandibular                             (50)         (50)                                                             
   Lymph Node, Mesenteric                             (50)         (50)                                                             
   Spleen                                             (50)         (50)                                                             
      Leiomyosarcoma, Metastatic, Stomach,                                                                                          
          Forestomach                                  1 (2%)                                                                       
   Thymus                                             (47)         (46)                                                             
      Thymoma Benign                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)                                                             
      Fibroadenoma                                     3 (6%)       2 (4%)                                                          
   Skin                                               (50)         (50)                                                             
      Basal Cell Adenoma                               2 (4%)       1 (2%)                                                          
      Keratoacanthoma                                  3 (6%)       1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Trichoepithelioma                                             2 (4%)                                                          
      Subcutaneous Tissue, Fibroma                     2 (4%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (1)          (2)                                                              
      Fibrous Histiocytoma                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Astrocytoma Malignant                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (4%)                                                          
   Nose                                               (50)         (50)                                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

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NTP Experiment-Test: 05099-98  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 05/10/95  
Route: GAVAGE                                                                                                     Time: 11:56:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG                                                             
                                                   AD LIB       RTD                                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (1)                                                              
      Carcinoma                                        1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            13 (26%)     10 (20%)                                                         
      Mesothelioma Malignant                           1 (2%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

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NTP Experiment-Test: 05099-98  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                      SALICYLAZOSULFAPYRIDINE                                  Date: 05/10/95  
Route: GAVAGE                                                                                                     Time: 11:56:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      0 MG/KG                                                             
                                                   AD LIB       RTD                                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          48                                                               
     Total Primary Neoplasms                          144         114                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          48                                                               
     Total Benign Neoplasms                           114          94                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23          17                                                               
     Total Malignant Neoplasms                         30          20                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          5                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

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