National Toxicology Program

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TDMS Study 05121-99 Pathology Tables

NTP                                            STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
AB: BATTELLE COLUMBUS                             SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                         DATE: 03/22/95       
XPERIMENT: 05121 TEST: 99                                                                                     TIME: 13:54:07       
EST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
ONT: N01-ES-85227          ROUTE: GAVAGE                                                                      NTP C#: 03098C       
ATHOLOGIST: A. SINGER                                                                                         CAS: 6533-68-2       
-----------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                   
                                                  05121/07 - 05121/08 COMPARISON                                                   
                                                                                                                                   
              REASONS FOR REMOVAL:    25022 Accidently Killed                                                                      
                                      25018 Dosing Accident                                                                        
                                      25019 Moribund Sacrifice                                                                     
                                      25020 Natural Death                                                                          
                                      25021 Terminal Sacrifice                                                                     
                                                                                                                                   
                                                                                                                                   
                                                                                                                                   
                                                                                                                                   
                                                                                                                                   
                                                                                                                                   
                                                                                                                                   
                                                                                                                                   
                                                                                                                                   
              REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                   
              TREATMENT GROUPS:       INCLUDE 001    0 MG/KG                                                                       
                                      INCLUDE 002    0 MG/KG                                                                       
                                      INCLUDE 003    RTD     0 MG/KG                                                               
                                      INCLUDE 005    RTD     0 MG/KG                                                               

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: BATTELLE COLUMBUS                             SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                         DATE: 03/22/95       
EXPERIMENT: 05121 TEST: 99                                                                                     TIME: 13:54:87       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85227          ROUTE: GAVAGE                                                                      NTP C#: 03098C       
PATHOLOGIST: A. SINGER                                                                                         CAS: 6533-68-2       




                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: BATTELLE COLUMBUS                             SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                         DATE: 03/22/95       
EXPERIMENT: 05121 TEST: 99                                                                                     TIME: 13:54:87       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-85227          ROUTE: GAVAGE                                                                      NTP C#: 03098C       
PATHOLOGIST: A. SINGER                                                                                         CAS: 6533-68-2       




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                              IN THE ANALYSIS OF THE STUDY OF SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

              ====================================================================================================

                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------

                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             All Organs                    Malignant Lymphoma And Histiocytic Sarcoma
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors

              ====================================================================================================

                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------

                             Liver                         Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             All Organs                    Hemangiosarcoma
                                                           Hemangiosarcoma or Hemangioma
                                                           Malignant Lymphoma And Histiocytic Sarcoma
                                                           Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,
                                                            NOS, or Undifferentiated Cell Type
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors

              ====================================================================================================

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE   1
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         3/50 (6%)           2/50 (4%)              |         1/51 (2%)           3/50 (6%)              |
|ADJUSTED (b)           |          6.9%                4.1%                  |          3.0%                6.4%                  |
|TERMINAL (d)           |         2/41 (5%)           2/49 (4%)              |         1/33 (3%)           3/47 (6%)              |
|FIRST INCIDENCE (DAYS) |          540                 722 (T)               |          723 (T)             723 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.434N               |                             P=0.438                |
|INCIDENTAL TUMOR       |                             P=0.496N               |                             P=0.438                |
|LOGISTIC REGRESSION    |                             P=0.556N               |                             P=0.438                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.301                |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           0/50 (0%)              |         2/51 (4%)           0/50 (0%)              |
|ADJUSTED (b)           |          0.0%                0.0%                  |          4.3%                0.0%                  |
|TERMINAL (d)           |         0/41 (0%)           0/49 (0%)              |         0/33 (0%)           0/47 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          511                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.228N               |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.518N               |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.339N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.252N               |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE   2
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               | 
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         3/50 (6%)           2/50 (4%)              |         3/51 (6%)           3/50 (6%)              |
|ADJUSTED (b)           |          6.9%                4.1%                  |          7.2%                6.4%                  |
|TERMINAL (d)           |         2/41 (5%)           2/49 (4%)              |         1/33 (3%)           3/47 (6%)              |
|FIRST INCIDENCE (DAYS) |          540                 722 (T)               |          511                 723 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.434N               |                             P=0.541N               |
|INCIDENTAL TUMOR       |                             P=0.496N               |                             P=0.612                |
|LOGISTIC REGRESSION    |                             P=0.556N               |                             P=0.609                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.652                |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         3/50 (6%)           0/50 (0%)              |         0/51 (0%)           0/50 (0%)              |
|ADJUSTED (b)           |          6.9%                0.0%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         2/41 (5%)           0/49 (0%)              |         0/33 (0%)           0/47 (0%)              |
|FIRST INCIDENCE (DAYS) |          647                 ---                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.101N               |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.200N               |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.126N               |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.121N               |                               (e)                  |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE   3
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           0/50 (0%)              |         0/51 (0%)           0/50 (0%)              |
|ADJUSTED (b)           |          4.9%                0.0%                  |          0.0%                0.0%                  |
|TERMINAL (d)           |         2/41 (5%)           0/49 (0%)              |         0/33 (0%)           0/47 (0%)              |
|FIRST INCIDENCE (DAYS) |          722 (T)             ---                   |          ---                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.200N               |           (e)                 (e)                  |
|INCIDENTAL TUMOR       |                             P=0.200N               |           (e)                 (e)                  |
|LOGISTIC REGRESSION    |                             P=0.200N               |           (e)                 (e)                  |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.247N               |                               (e)                  |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        26/50 (52%)          3/50 (6%)              |        15/51 (29%)          3/50 (6%)              |
|ADJUSTED (b)           |         59.0%                6.1%                  |         42.3%                6.4%                  |
|TERMINAL (d)           |        23/41 (56%)          3/49 (6%)              |        13/33 (39%)          3/47 (6%)              |
|FIRST INCIDENCE (DAYS) |          680                 722 (T)               |          604                 723 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P<0.001N**             |                             P<0.001N**             |
|INCIDENTAL TUMOR       |                             P<0.001N**             |                             P<0.001N**             |
|LOGISTIC REGRESSION    |                             P<0.001N**             |                             P<0.001N**             |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P<0.001N**             |                             P=0.002N**             |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE   4
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         6/50 (12%)          2/50 (4%)              |         8/51 (16%)          0/50 (0%)              |
|ADJUSTED (b)           |         14.0%                4.1%                  |         21.1%                0.0%                  |
|TERMINAL (d)           |         4/41 (10%)          2/49 (4%)              |         5/33 (15%)          0/47 (0%)              |
|FIRST INCIDENCE (DAYS) |          700                 722 (T)               |          594                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.091N               |                             P=0.002N**             |
|INCIDENTAL TUMOR       |                             P=0.259N               |                             P=0.010N*              |
|LOGISTIC REGRESSION    |                             P=0.116N               |                             P=0.005N**             |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.134N               |                             P=0.003N**             |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        30/50 (60%)          5/50 (10%)             |        22/51 (43%)          3/50 (6%)              |
|ADJUSTED (b)           |         65.2%               10.2%                  |         57.1%                6.4%                  |
|TERMINAL (d)           |        25/41 (61%)          5/49 (10%)             |        17/33 (52%)          3/47 (6%)              |
|FIRST INCIDENCE (DAYS) |          680                 722 (T)               |          594                 723 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P<0.001N**             |                             P<0.001N**             |
|INCIDENTAL TUMOR       |                             P<0.001N**             |                             P<0.001N**             |
|LOGISTIC REGRESSION    |                             P<0.001N**             |                             P<0.001N**             |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P<0.001N**             |                             P<0.001N**             |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE   5
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        30/50 (60%)          5/50 (10%)             |        22/51 (43%)          3/50 (6%)              |
|ADJUSTED (b)           |         65.2%               10.2%                  |         57.1%                6.4%                  |
|TERMINAL (d)           |        25/41 (61%)          5/49 (10%)             |        17/33 (52%)          3/47 (6%)              |
|FIRST INCIDENCE (DAYS) |          680                 722 (T)               |          594                 723 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P<0.001N**             |                             P<0.001N**             |
|INCIDENTAL TUMOR       |                             P<0.001N**             |                             P<0.001N**             |
|LOGISTIC REGRESSION    |                             P<0.001N**             |                             P<0.001N**             |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P<0.001N**             |                             P<0.001N**             |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        12/50 (24%)          8/50 (16%)             |         3/51 (6%)           3/50 (6%)              |
|ADJUSTED (b)           |         27.8%               16.3%                  |          8.0%                6.4%                  |
|TERMINAL (d)           |        10/41 (24%)          8/49 (16%)             |         1/33 (3%)           3/47 (6%)              |
|FIRST INCIDENCE (DAYS) |          683                 722 (T)               |          618                 723 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.123N               |                             P=0.517N               |
|INCIDENTAL TUMOR       |                             P=0.247N               |                             P=0.527                |
|LOGISTIC REGRESSION    |                             P=0.179N               |                             P=0.652N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.227N               |                             P=0.652                |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE   6
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         3/50 (6%)           2/50 (4%)              |         1/51 (2%)           3/50 (6%)              |
|ADJUSTED (b)           |          6.8%                4.1%                  |          3.0%                6.3%                  |
|TERMINAL (d)           |         1/41 (2%)           2/49 (4%)              |         1/33 (3%)           2/47 (4%)              |
|FIRST INCIDENCE (DAYS) |          680                 722 (T)               |          723 (T)             628                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.435N               |                             P=0.422                |
|INCIDENTAL TUMOR       |                             P=0.562                |                             P=0.292                |
|LOGISTIC REGRESSION    |                             P=0.499N               |                             P=0.305                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.301                |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        15/50 (30%)         10/50 (20%)             |         4/51 (8%)           6/50 (12%)             |
|ADJUSTED (b)           |         33.2%               20.4%                  |         10.8%               12.5%                  |
|TERMINAL (d)           |        11/41 (27%)         10/49 (20%)             |         2/33 (6%)           5/47 (11%)             |
|FIRST INCIDENCE (DAYS) |          680                 722 (T)               |          618                 628                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.088N               |                             P=0.567                |
|INCIDENTAL TUMOR       |                             P=0.321N               |                             P=0.245                |
|LOGISTIC REGRESSION    |                             P=0.142N               |                             P=0.381                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.178N               |                             P=0.358                |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE   7
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |         3/51 (6%)           0/50 (0%)              |
|ADJUSTED (b)           |                                                    |          7.1%                0.0%                  |
|TERMINAL (d)           |                                                    |         0/33 (0%)           0/47 (0%)              |
|FIRST INCIDENCE (DAYS) |                                                    |          511                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |                             P=0.100N               |
|INCIDENTAL TUMOR       |                                                    |                             P=0.718N               |
|LOGISTIC REGRESSION    |                                                    |                             P=0.158N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                                                    |                             P=0.125N               |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/48 (0%)           0/48 (0%)              |         4/50 (8%)           0/46 (0%)              |
|ADJUSTED (b)           |          0.0%                0.0%                  |         11.8%                0.0%                  |
|TERMINAL (d)           |         0/40 (0%)           0/47 (0%)              |         3/33 (9%)           0/44 (0%)              |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          720                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.033N*              |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.076N               |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.041N*              |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.069N               |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE   8
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           2/50 (4%)              |                                                    |
|ADJUSTED (b)           |          0.0%                4.1%                  |                                                    |
|TERMINAL (d)           |         0/41 (0%)           2/49 (4%)              |                                                    |
|FIRST INCIDENCE (DAYS) |          ---                 722 (T)               |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.279                |                                                    |
|INCIDENTAL TUMOR       |                             P=0.279                |                                                    |
|LOGISTIC REGRESSION    |                             P=0.279                |                                                    |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.247                |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         0/50 (0%)           0/50 (0%)              |         3/51 (6%)           1/50 (2%)              |
|ADJUSTED (b)           |          0.0%                0.0%                  |          9.1%                2.1%                  |
|TERMINAL (d)           |         0/41 (0%)           0/49 (0%)              |         3/33 (9%)           1/47 (2%)              |
|FIRST INCIDENCE (DAYS) |          ---                 ---                   |          723 (T)             723 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |           (e)                 (e)                  |                             P=0.189N               |
|INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.189N               |
|LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.189N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                               (e)                  |                             P=0.316N               |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE   9
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |         2/51 (4%)           0/50 (0%)              |
|ADJUSTED (b)           |                                                    |          6.1%                0.0%                  |
|TERMINAL (d)           |                                                    |         2/33 (6%)           0/47 (0%)              |
|FIRST INCIDENCE (DAYS) |                                                    |          723 (T)             ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |                             P=0.165N               |
|INCIDENTAL TUMOR       |                                                    |                             P=0.165N               |
|LOGISTIC REGRESSION    |                                                    |                             P=0.165N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                                                    |                             P=0.252N               |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         1/50 (2%)           1/50 (2%)              |         4/51 (8%)           0/50 (0%)              |
|ADJUSTED (b)           |          2.4%                2.0%                  |         11.3%                0.0%                  |
|TERMINAL (d)           |         1/41 (2%)           1/49 (2%)              |         2/33 (6%)           0/47 (0%)              |
|FIRST INCIDENCE (DAYS) |          722 (T)             722 (T)               |          709                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.721N               |                             P=0.033N*              |
|INCIDENTAL TUMOR       |                             P=0.721N               |                             P=0.165N               |
|LOGISTIC REGRESSION    |                             P=0.721N               |                             P=0.042N*              |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.753N               |                             P=0.061N               |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE  10
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         2/50 (4%)           1/50 (2%)              |         4/51 (8%)           0/50 (0%)              |
|ADJUSTED (b)           |          4.6%                2.0%                  |         11.3%                0.0%                  |
|TERMINAL (d)           |         1/41 (2%)           1/49 (2%)              |         2/33 (6%)           0/47 (0%)              |
|FIRST INCIDENCE (DAYS) |          680                 722 (T)               |          709                 ---                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.452N               |                             P=0.033N*              |
|INCIDENTAL TUMOR       |                             P=0.721N               |                             P=0.165N               |
|LOGISTIC REGRESSION    |                             P=0.502N               |                             P=0.042N*              |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.500N               |                             P=0.061N               |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         3/50 (6%)           0/50 (0%)              |         1/51 (2%)           2/50 (4%)              |
|ADJUSTED (b)           |          6.8%                0.0%                  |          2.0%                4.1%                  |
|TERMINAL (d)           |         2/41 (5%)           0/49 (0%)              |         0/33 (0%)           1/47 (2%)              |
|FIRST INCIDENCE (DAYS) |          447                 ---                   |          492                 492                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.102N               |                             P=0.545                |
|INCIDENTAL TUMOR       |                             P=0.137N               |                             P=0.278                |
|LOGISTIC REGRESSION    |                             P=0.179N               |                             P=0.323                |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.121N               |                             P=0.492                |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE  11
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         7/50 (14%)          1/50 (2%)              |        10/51 (20%)          4/50 (8%)              |
|ADJUSTED (b)           |         15.9%                2.0%                  |         24.6%                8.3%                  |
|TERMINAL (d)           |         5/41 (12%)          0/49 (0%)              |         5/33 (15%)          3/47 (6%)              |
|FIRST INCIDENCE (DAYS) |          447                 515                   |          492                 492                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.024N*              |                             P=0.032N*              |
|INCIDENTAL TUMOR       |                             P=0.056N               |                             P=0.189N               |
|LOGISTIC REGRESSION    |                             P=0.059N               |                             P=0.117N               |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.030N*              |                             P=0.080N               |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |         4/50 (8%)           1/50 (2%)              |         9/51 (18%)          2/50 (4%)              |
|ADJUSTED (b)           |          9.3%                2.0%                  |         23.0%                4.3%                  |
|TERMINAL (d)           |         3/41 (7%)           0/49 (0%)              |         5/33 (15%)          2/47 (4%)              |
|FIRST INCIDENCE (DAYS) |          680                 515                   |          581                 723 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.148N               |                             P=0.010N**             |
|INCIDENTAL TUMOR       |                             P=0.316N               |                             P=0.052N               |
|LOGISTIC REGRESSION    |                             P=0.229N               |                             P=0.029N*              |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.181N               |                             P=0.028N*              |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE  12
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        36/50 (72%)         14/50 (28%)             |        24/51 (47%)         12/50 (24%)             |
|ADJUSTED (b)           |         78.2%               28.6%                  |         60.9%               25.5%                  |
|TERMINAL (d)           |        31/41 (76%)         14/49 (29%)             |        18/33 (55%)         12/47 (26%)             |
|FIRST INCIDENCE (DAYS) |          540                 722 (T)               |          511                 723 (T)               |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P<0.001N**             |                             P<0.001N**             |
|INCIDENTAL TUMOR       |                             P<0.001N**             |                             P=0.005N**             |
|LOGISTIC REGRESSION    |                             P<0.001N**             |                             P=0.005N**             |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P<0.001N**             |                             P=0.013N*              |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        17/50 (34%)          6/50 (12%)             |        26/51 (51%)          8/50 (16%)             |
|ADJUSTED (b)           |         36.8%               12.0%                  |         54.8%               16.0%                  |
|TERMINAL (d)           |        12/41 (29%)          5/49 (10%)             |        12/33 (36%)          5/47 (11%)             |
|FIRST INCIDENCE (DAYS) |          447                 515                   |          492                 492                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P=0.004N**             |                             P<0.001N**             |
|INCIDENTAL TUMOR       |                             P=0.037N*              |                             P=0.018N*              |
|LOGISTIC REGRESSION    |                             P=0.013N*              |                             P=0.003N**             |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P=0.008N**             |                             P<0.001N**             |
|=================================================================================================================================|

         DATE: 03/22/95                     EXPERIMENT: 05121 TEST: 99                                                 PAGE  13
                     STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- SCOPOLAMINE HYDROBROMIDE TRIHYDRATE

                                                 TERMINAL SACRIFICE AT 104 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |          0 MG/KG             RTD                   |         0 MG/KG              RTD                   |
|                       |                              0 MG/KG               |                              0 MG/KG               |  
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |           #                   #                    |           #                   #                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |        43/50 (86%)         19/50 (38%)             |        40/51 (78%)         19/50 (38%)             |
|ADJUSTED (b)           |         87.8%               38.0%                  |         83.2%               38.0%                  |
|TERMINAL (d)           |        35/41 (85%)         18/49 (37%)             |        25/33 (76%)         16/47 (34%)             |
|FIRST INCIDENCE (DAYS) |          447                 515                   |          492                 492                   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                             P<0.001N**             |                             P<0.001N**             |
|INCIDENTAL TUMOR       |                             P<0.001N**             |                             P<0.001N**             |
|LOGISTIC REGRESSION    |                             P<0.001N**             |                             P<0.001N**             |
|COCHRAN-ARMITAGE       |                                                    |                                                    |
|FISHER EXACT           |                             P<0.001N**             |                             P<0.001N**             |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.