National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4057

TDMS Study 05217-99 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                        T-BUTYLHYDROQUINONE


NTP Experiment-Test: 05217-99                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 04/07/95
Route: DOSED FEED                                                                                                 Time: 14:28:37


                                               05217/03 -VS- 05217/04 COMPARISON


       Facility:  SOUTHERN RESEARCH INSTITUTE

       Chemical CAS #:  1948-33-0

       Lock Date:  05/26/93

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    UNTREATD CONTROL
                               Include 002    UNTREATD CONTROL
                               Include 005    RTD UNTRCONTROL
                               Include 006    RTD UNTRCONTROL



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          70           70                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                40           39                                                               
    Natural Death                                     10            3                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           18                                                               

  Animals Examined Microscopically                    60           60                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (58)         (58)                                                             
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Intestine Large, Colon                             (60)         (59)                                                             
      Parasite Metazoan                                6 (10%)      4 (7%)                                                          
   Intestine Large, Rectum                            (59)         (60)                                                             
      Edema                                            1 (2%)                                                                       
      Parasite Metazoan                                2 (3%)       5 (8%)                                                          
   Intestine Large, Cecum                             (60)         (60)                                                             
      Edema                                                         1 (2%)                                                          
      Parasite Metazoan                                2 (3%)       1 (2%)                                                          
   Intestine Small, Duodenum                          (59)         (59)                                                             
      Erosion                                                       1 (2%)                                                          
      Epithelium, Hyperplasia                                       1 (2%)                                                          
   Liver                                              (60)         (60)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                26 (43%)     26 (43%)                                                         
      Clear Cell Focus                                 2 (3%)       2 (3%)                                                          
      Degeneration, Cystic                             1 (2%)                                                                       
      Eosinophilic Focus                              10 (17%)      7 (12%)                                                         
      Hematopoietic Cell Proliferation                 1 (2%)       2 (3%)                                                          
      Hepatodiaphragmatic Nodule                      12 (20%)      2 (3%)                                                          
      Inflammation, Granulomatous                     12 (20%)      7 (12%)                                                         
      Inflammation, Subacute                                        1 (2%)                                                          
      Mixed Cell Focus                                 2 (3%)       8 (13%)                                                         
      Necrosis, Focal                                  6 (10%)      7 (12%)                                                         
      Bile Duct, Hyperplasia                          17 (28%)     23 (38%)                                                         
      Hepatocyte, Vacuolization Cytoplasmic           14 (23%)      7 (12%)                                                         
      Kupffer Cell, Pigmentation                      12 (20%)     14 (23%)                                                         
   Mesentery                                          (11)         (8)                                                              
      Accessory Spleen                                 1 (9%)       2 (25%)                                                         
      Fat, Necrosis                                    9 (82%)      5 (63%)                                                         
   Pancreas                                           (60)         (60)                                                             
      Atrophy                                         20 (33%)     15 (25%)                                                         
      Metaplasia, Hepatocyte                           1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Cytoplasmic Alteration                                1 (2%)                                                          
   Salivary Glands                                    (60)         (60)                                                             
      Atrophy                                          2 (3%)                                                                       
   Stomach, Forestomach                               (60)         (59)                                                             
      Edema                                            4 (7%)       1 (2%)                                                          
      Erosion                                          1 (2%)       1 (2%)                                                          
      Ulcer                                            2 (3%)       4 (7%)                                                          
      Epithelium, Hyperplasia                                       5 (8%)                                                          
      Mucosa, Hyperplasia                              5 (8%)                                                                       
   Stomach, Glandular                                 (60)         (59)                                                             
      Edema                                            1 (2%)       1 (2%)                                                          
      Erosion                                          3 (5%)       1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Ulcer                                            2 (3%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)                                                             
      Cardiomyopathy                                  28 (47%)     29 (48%)                                                         
      Mineralization                                                1 (2%)                                                          
      Thrombosis                                       3 (5%)       2 (3%)                                                          
      Schwann Cell, Hyperplasia                                     1 (2%)                                                          
      Valve, Inflammation, Chronic                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)                                                             
      Accessory Adrenal Cortical Nodule               11 (18%)      9 (15%)                                                         
      Atrophy                                          1 (2%)                                                                       
      Degeneration, Fatty                              9 (15%)     11 (18%)                                                         
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Diffuse                             3 (5%)       1 (2%)                                                          
      Hyperplasia, Focal                               3 (5%)       7 (12%)                                                         
      Hypertrophy, Focal                               9 (15%)      5 (8%)                                                          
      Necrosis                                                      1 (2%)                                                          
   Adrenal Medulla                                    (60)         (57)                                                             
      Hyperplasia                                      5 (8%)       5 (9%)                                                          
   Islets, Pancreatic                                 (60)         (60)                                                             
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (52)         (55)                                                             
      Hyperplasia                                      1 (2%)       2 (4%)                                                          
   Pituitary Gland                                    (60)         (59)                                                             
      Pars Distalis, Angiectasis                       8 (13%)      2 (3%)                                                          
      Pars Distalis, Cyst                             14 (23%)      9 (15%)                                                         
      Pars Distalis, Hyperplasia, Focal                9 (15%)     11 (19%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Intermedia, Angiectasis                                  2 (3%)                                                          
      Pars Intermedia, Cyst                            2 (3%)       4 (7%)                                                          
   Thyroid Gland                                      (60)         (60)                                                             
      Ultimobranchial Cyst                             2 (3%)       2 (3%)                                                          
      C-Cell, Hyperplasia                              8 (13%)      4 (7%)                                                          
      Follicle, Cyst                                   1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (59)                                                             
      Cyst                                             2 (3%)       5 (8%)                                                          
      Cyst, Multiple                                   1 (2%)                                                                       
      Hyperplasia                                      3 (5%)       5 (8%)                                                          
      Inflammation, Chronic                            2 (3%)       3 (5%)                                                          
      Inflammation, Suppurative                        2 (3%)       2 (3%)                                                          
   Ovary                                              (60)         (60)                                                             
      Angiectasis                                                   2 (3%)                                                          
      Cyst                                            17 (28%)      6 (10%)                                                         
   Uterus                                             (60)         (60)                                                             
      Hydrometra                                       3 (5%)       4 (7%)                                                          
      Hyperplasia, Cystic                              4 (7%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)                                                             
      Depletion Cellular                               1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Myelofibrosis                                    2 (3%)       1 (2%)                                                          
   Lymph Node                                         (20)         (19)                                                             
      Iliac, Ectasia                                                1 (5%)                                                          
      Mediastinal, Ectasia                             1 (5%)                                                                       
      Mediastinal, Hemorrhage                          3 (15%)                                                                      
      Mediastinal, Hyperplasia, Lymphoid               1 (5%)                                                                       
      Mediastinal, Pigmentation                       14 (70%)      8 (42%)                                                         
      Pancreatic, Ectasia                                           1 (5%)                                                          
      Pancreatic, Pigmentation                         1 (5%)       2 (11%)                                                         
      Renal, Pigmentation                              1 (5%)       6 (32%)                                                         
   Lymph Node, Mandibular                             (59)         (60)                                                             
      Ectasia                                          2 (3%)       3 (5%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage                                       3 (5%)       5 (8%)                                                          
      Hyperplasia, Lymphoid                           13 (22%)      9 (15%)                                                         
      Hyperplasia, Plasma Cell                         1 (2%)       1 (2%)                                                          
      Pigmentation                                    20 (34%)     22 (37%)                                                         
   Lymph Node, Mesenteric                             (58)         (59)                                                             
      Ectasia                                          2 (3%)       1 (2%)                                                          
      Hemorrhage                                                    2 (3%)                                                          
      Hyperplasia, Lymphoid                            2 (3%)       1 (2%)                                                          
   Spleen                                             (60)         (60)                                                             
      Fibrosis                                         3 (5%)       4 (7%)                                                          
      Hematopoietic Cell Proliferation                15 (25%)      9 (15%)                                                         
      Necrosis                                                      1 (2%)                                                          
      Pigmentation, Hemosiderin                       24 (40%)     30 (50%)                                                         
      Lymphoid Follicle, Atrophy                       1 (2%)                                                                       
      Red Pulp, Atrophy                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)                                                             
      Dilatation                                      37 (62%)     51 (85%)                                                         
      Galactocele                                      5 (8%)       1 (2%)                                                          
      Hyperplasia                                     12 (20%)      3 (5%)                                                          
   Skin                                               (60)         (60)                                                             
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                                         1 (2%)                                                          
      Epidermis, Hyperplasia                           1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)                                                             
      Fibrous Osteodystrophy                                        2 (3%)                                                          
      Cranium, Osteopetrosis                           8 (13%)      3 (5%)                                                          
      Femur, Osteopetrosis                             9 (15%)      3 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)                                                             
      Atrophy                                         19 (32%)     17 (28%)                                                         
      Hemorrhage                                                    1 (2%)                                                          
      Hydrocephalus                                    4 (7%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)                                                             
      Congestion                                       1 (2%)                                                                       
      Edema                                                         1 (2%)                                                          
      Foreign Body                                                  1 (2%)                                                          
      Hemorrhage                                       2 (3%)       2 (3%)                                                          
      Infiltration Cellular, Histiocyte               28 (47%)     33 (55%)                                                         
      Inflammation, Subacute                           3 (5%)       1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Thrombosis                                       1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 4 (7%)       3 (5%)                                                          
   Nose                                               (60)         (60)                                                             
      Foreign Body                                     3 (5%)       1 (2%)                                                          
      Inflammation, Suppurative                        5 (8%)       3 (5%)                                                          
      Goblet Cell, Hyperplasia                        10 (17%)      7 (12%)                                                         
      Mucosa, Hyperplasia                              5 (8%)       4 (7%)                                                          
      Mucosa, Metaplasia, Squamous                     3 (5%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)                                                              
      Inflammation, Chronic                                         1 (50%)                                                         
   Eye                                                (4)                                                                           
      Cataract                                         3 (75%)                                                                      
      Hemorrhage                                       1 (25%)                                                                      
      Retina, Degeneration                             4 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)                                                             
      Glomerulosclerosis                                            1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Inflammation, Suppurative                        2 (3%)                                                                       
      Mineralization                                  57 (95%)     59 (98%)                                                         
      Nephropathy                                     37 (62%)     38 (63%)                                                         
      Renal Tubule, Atrophy                            1 (2%)       1 (2%)                                                          
      Renal Tubule, Cytoplasmic Alteration             5 (8%)       5 (8%)                                                          
      Renal Tubule, Dilatation                                      2 (3%)                                                          
      Renal Tubule, Necrosis                           2 (3%)       1 (2%)                                                          
      Renal Tubule, Pigmentation                      15 (25%)     17 (28%)                                                         
      Transitional Epithelium, Hyperplasia             2 (3%)       5 (8%)                                                          
   Urinary Bladder                                    (59)         (60)                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          70           70                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                48           41                                                               
    Natural Death                                      4            6                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                              2                                                               
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                 8           10                                                               

  Animals Examined Microscopically                    60           60                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (58)         (60)                                                             
      Parasite Metazoan                                7 (12%)      7 (12%)                                                         
   Intestine Large, Rectum                            (59)         (59)                                                             
      Edema                                            2 (3%)                                                                       
      Parasite Metazoan                                5 (8%)       4 (7%)                                                          
   Intestine Large, Cecum                             (60)         (60)                                                             
      Edema                                            3 (5%)       3 (5%)                                                          
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Small, Duodenum                          (60)         (60)                                                             
      Ulcer                                                         3 (5%)                                                          
      Epithelium, Hyperplasia                          2 (3%)                                                                       
   Intestine Small, Jejunum                           (60)         (60)                                                             
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Liver                                              (60)         (60)                                                             
      Angiectasis                                     10 (17%)      5 (8%)                                                          
      Basophilic Focus                                 7 (12%)      5 (8%)                                                          
      Clear Cell Focus                                 1 (2%)                                                                       
      Degeneration, Cystic                            23 (38%)      6 (10%)                                                         
      Eosinophilic Focus                              10 (17%)      6 (10%)                                                         
      Eosinophilic Focus, Multiple                     1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       7 (12%)      2 (3%)                                                          
      Mixed Cell Focus                                 2 (3%)                                                                       
      Necrosis, Focal                                  8 (13%)      7 (12%)                                                         
      Thrombosis                                       1 (2%)                                                                       
      Bile Duct, Cyst                                  2 (3%)                                                                       
      Bile Duct, Hyperplasia                          52 (87%)     45 (75%)                                                         
      Centrilobular, Necrosis                          2 (3%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            6 (10%)      2 (3%)                                                          
      Kupffer Cell, Hyperplasia                                     1 (2%)                                                          
      Kupffer Cell, Pigmentation                      11 (18%)     19 (32%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (20)         (8)                                                              
      Accessory Spleen                                 1 (5%)       2 (25%)                                                         
      Fat, Necrosis                                   16 (80%)      4 (50%)                                                         
   Pancreas                                           (60)         (58)                                                             
      Atrophy                                         15 (25%)     21 (36%)                                                         
      Acinus, Cytoplasmic Alteration                   3 (5%)                                                                       
      Acinus, Hyperplasia, Focal                       2 (3%)                                                                       
   Salivary Glands                                    (60)         (60)                                                             
      Atrophy                                                       1 (2%)                                                          
   Stomach, Forestomach                               (60)         (60)                                                             
      Edema                                            9 (15%)                                                                      
      Hyperplasia                                      8 (13%)      5 (8%)                                                          
      Ulcer                                            8 (13%)      1 (2%)                                                          
      Mucosa, Hyperplasia                              1 (2%)                                                                       
   Stomach, Glandular                                 (60)         (60)                                                             
      Edema                                            1 (2%)       1 (2%)                                                          
      Erosion                                          1 (2%)       1 (2%)                                                          
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            3 (5%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (60)         (60)                                                             
      Hypertrophy                                      1 (2%)       1 (2%)                                                          
      Inflammation, Subacute                           1 (2%)       1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
   Heart                                              (60)         (60)                                                             
      Cardiomyopathy                                  40 (67%)     34 (57%)                                                         
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                       6 (10%)      5 (8%)                                                          
      Endocardium, Hyperplasia                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)                                                             
      Accessory Adrenal Cortical Nodule               17 (28%)     13 (22%)                                                         
      Angiectasis                                                   1 (2%)                                                          
      Degeneration, Fatty                              9 (15%)     13 (22%)                                                         
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Diffuse                                          1 (2%)                                                          
      Hyperplasia, Focal                               4 (7%)       2 (3%)                                                          
      Hypertrophy, Focal                               6 (10%)      5 (8%)                                                          
      Necrosis                                         1 (2%)                                                                       
   Adrenal Medulla                                    (60)         (59)                                                             
      Hyperplasia                                     26 (43%)     18 (31%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Islets, Pancreatic                                 (60)         (58)                                                             
      Hyperplasia                                      3 (5%)       2 (3%)                                                          
   Parathyroid Gland                                  (55)         (56)                                                             
      Hyperplasia                                      6 (11%)                                                                      
   Pituitary Gland                                    (60)         (57)                                                             
      Pars Distalis, Angiectasis                       4 (7%)       3 (5%)                                                          
      Pars Distalis, Cyst                              6 (10%)      7 (12%)                                                         
      Pars Distalis, Cyst, Hemorrhagic                 1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal               10 (17%)     14 (25%)                                                         
      Pars Intermedia, Cyst                            1 (2%)       2 (4%)                                                          
   Thyroid Gland                                      (60)         (60)                                                             
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                              9 (15%)      5 (8%)                                                          
      Follicle, Cyst                                   1 (2%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)                                                             
      Atypia Cellular                                 27 (45%)     25 (42%)                                                         
   Preputial Gland                                    (60)         (60)                                                             
      Cyst                                             3 (5%)       3 (5%)                                                          
      Hyperplasia                                      3 (5%)       1 (2%)                                                          
      Inflammation, Chronic                           26 (43%)      9 (15%)                                                         
      Inflammation, Suppurative                        3 (5%)       1 (2%)                                                          
   Prostate                                           (60)         (60)                                                             
      Cyst                                             1 (2%)                                                                       
      Fibrosis                                         3 (5%)                                                                       
      Inflammation, Chronic                            5 (8%)                                                                       
      Inflammation, Suppurative                       36 (60%)     28 (47%)                                                         
      Epithelium, Hyperplasia                         11 (18%)      3 (5%)                                                          
   Testes                                             (60)         (60)                                                             
      Atrophy                                                       2 (3%)                                                          
      Interstitial Cell, Hyperplasia                   4 (7%)       3 (5%)                                                          
      Seminiferous Tubule, Atrophy                     7 (12%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)                                                             
      Hyperplasia                                      6 (10%)      2 (3%)                                                          
      Myelofibrosis                                    4 (7%)       8 (13%)                                                         
   Lymph Node                                         (33)         (36)                                                             
      Iliac, Hemorrhage                                1 (3%)                                                                       
      Inguinal, Hyperplasia, Lymphoid                  2 (6%)                                                                       
      Mediastinal, Hemorrhage                          3 (9%)       2 (6%)                                                          
      Mediastinal, Hyperplasia, Lymphoid               1 (3%)                                                                       
      Mediastinal, Pigmentation                       13 (39%)     19 (53%)                                                         
      Pancreatic, Pigmentation                         9 (27%)      8 (22%)                                                         
      Renal, Hemorrhage                                1 (3%)       1 (3%)                                                          
      Renal, Pigmentation                              8 (24%)      7 (19%)                                                         
   Lymph Node, Mandibular                             (60)         (60)                                                             
      Ectasia                                          3 (5%)       2 (3%)                                                          
      Hemorrhage                                       2 (3%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                           11 (18%)      5 (8%)                                                          
      Hyperplasia, Plasma Cell                                      1 (2%)                                                          
      Pigmentation                                     6 (10%)     13 (22%)                                                         
   Lymph Node, Mesenteric                             (60)         (60)                                                             
      Ectasia                                          7 (12%)      2 (3%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            3 (5%)       1 (2%)                                                          
   Spleen                                             (60)         (60)                                                             
      Congestion                                       1 (2%)                                                                       
      Fibrosis                                        21 (35%)     13 (22%)                                                         
      Hematopoietic Cell Proliferation                 7 (12%)      2 (3%)                                                          
      Metaplasia, Lipocyte                             1 (2%)                                                                       
      Necrosis                                         2 (3%)       2 (3%)                                                          
      Pigmentation, Hemosiderin                       13 (22%)      3 (5%)                                                          
      Lymphoid Follicle, Atrophy                       1 (2%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (58)                                                             
      Dilatation                                      23 (40%)     16 (28%)                                                         
      Galactocele                                      5 (9%)                                                                       
      Hyperplasia                                      7 (12%)      7 (12%)                                                         
   Skin                                               (60)         (60)                                                             
      Cyst Epithelial Inclusion                        2 (3%)                                                                       
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
      Epidermis, Hyperplasia                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)                                                             
      Fibrous Osteodystrophy                           6 (10%)                                                                      
      Hyperostosis                                     1 (2%)                                                                       
      Femur, Osteopetrosis                             1 (2%)       2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)                                                             
      Atrophy                                         12 (20%)      3 (5%)                                                          
      Hemorrhage                                       2 (3%)       1 (2%)                                                          
      Hydrocephalus                                    4 (7%)       1 (2%)                                                          
      Necrosis                                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)                                                             
      Congestion                                       2 (3%)       1 (2%)                                                          
      Edema                                            1 (2%)       3 (5%)                                                          
      Hemorrhage                                       3 (5%)       4 (7%)                                                          
      Infiltration Cellular, Histiocyte               19 (32%)     14 (23%)                                                         
      Metaplasia, Osseous                              1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 4 (7%)       5 (8%)                                                          
   Nose                                               (60)         (60)                                                             
      Foreign Body                                     6 (10%)      3 (5%)                                                          
      Inflammation                                                  1 (2%)                                                          
      Inflammation, Suppurative                       17 (28%)      5 (8%)                                                          
      Goblet Cell, Hyperplasia                         5 (8%)       8 (13%)                                                         
      Mucosa, Hyperplasia                             14 (23%)      8 (13%)                                                         
      Mucosa, Metaplasia, Squamous                     8 (13%)      7 (12%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (1)                                                              
      Atrophy                                          2 (50%)                                                                      
      Cataract                                         1 (25%)      1 (100%)                                                        
      Retina, Degeneration                             1 (25%)      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05217-99         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/07/95  
Route: DOSED FEED                                                                                                 Time: 14:28:37  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)                                                             
      Cyst                                             2 (3%)       2 (3%)                                                          
      Infiltration Cellular, Lipocyte                               1 (2%)                                                          
      Inflammation, Suppurative                        9 (15%)                                                                      
      Mineralization                                  12 (20%)      4 (7%)                                                          
      Nephropathy                                     60 (100%)    51 (85%)                                                         
      Renal Tubule, Accumulation, Hyaline Droplet      1 (2%)       1 (2%)                                                          
      Renal Tubule, Atrophy                                         1 (2%)                                                          
      Renal Tubule, Necrosis                           3 (5%)       3 (5%)                                                          
      Renal Tubule, Pigmentation                      18 (30%)     17 (28%)                                                         
      Transitional Epithelium, Hyperplasia            13 (22%)      1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)                                                             
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia             2 (3%)       1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.