National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4061

TDMS Study 05217-99 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                        T-BUTYLHYDROQUINONE


NTP Experiment-Test: 05217-99                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 04/10/95
Route: DOSED FEED                                                                                                 Time: 14:53:49


                                               05217/03 -VS- 05217/04 COMPARISON


       Facility:  SOUTHERN RESEARCH INSTITUTE

       Chemical CAS #:  1948-33-0

       Lock Date:  05/26/93

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    UNTREATD CONTROL
                               Include 002    UNTREATD CONTROL
                               Include 005    RTD UNTRCONTROL
                               Include 006    RTD UNTRCONTROL



























a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           70                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                40           39                                                               
    Natural Death                                     10            3                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           18                                                               

  Animals Examined Microscopically                    60           60                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (60)         (60)                                                             
   Liver                                              (60)         (60)                                                             
      Hepatocellular Adenoma                                        1 (2%)                                                          
   Mesentery                                          (11)         (8)                                                              
      Sarcoma Stromal, Metastatic, Uterus              1 (9%)                                                                       
   Pancreas                                           (60)         (60)                                                             
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Salivary Glands                                    (60)         (60)                                                             
   Stomach, Forestomach                               (60)         (59)                                                             
   Stomach, Glandular                                 (60)         (59)                                                             
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)                                                             
      Adenoma                                          4 (7%)                                                                       
   Adrenal Medulla                                    (60)         (57)                                                             
      Pheochromocytoma Benign                          2 (3%)       3 (5%)                                                          
      Pheochromocytoma Benign, Multiple                             1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (60)                                                             
      Adenoma                                          2 (3%)       1 (2%)                                                          
   Parathyroid Gland                                  (52)         (55)                                                             
      Adenoma                                          2 (4%)                                                                       
   Pituitary Gland                                    (60)         (59)                                                             
      Pars Distalis, Adenoma                          26 (43%)     30 (51%)                                                         
      Pars Distalis, Carcinoma                         2 (3%)                                                                       

                                                             Page   2                                                               
NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (60)         (60)                                                             
      C-Cell, Adenoma                                  7 (12%)      3 (5%)                                                          
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (59)                                                             
      Adenoma                                          6 (10%)      3 (5%)                                                          
      Carcinoma                                        6 (10%)      2 (3%)                                                          
   Ovary                                              (60)         (60)                                                             
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
      Granulosa Cell Tumor Benign                      1 (2%)       2 (3%)                                                          
   Uterus                                             (60)         (60)                                                             
      Leiomyoma                                        1 (2%)                                                                       
      Polyp Stromal                                    6 (10%)      8 (13%)                                                         
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                  2 (3%)                                                                       
   Vagina                                                          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)                                                             
   Lymph Node                                         (20)         (19)                                                             
   Lymph Node, Mandibular                             (59)         (60)                                                             
   Lymph Node, Mesenteric                             (58)         (59)                                                             
   Spleen                                             (60)         (60)                                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (56)         (57)                                                             
      Thymoma Benign                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)                                                             
      Adenoma                                          3 (5%)                                                                       
      Carcinoma                                        8 (13%)      1 (2%)                                                          
      Fibroadenoma                                    28 (47%)     22 (37%)                                                         
      Fibroadenoma, Multiple                          15 (25%)      8 (13%)                                                         

                                                             Page   3                                                               
NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
   Skin                                               (60)         (60)                                                             
      Basal Cell Carcinoma                             1 (2%)       1 (2%)                                                          
      Trichoepithelioma                                             1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     3 (5%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)                                                              
      Sarcoma Stromal, Metastatic, Uterus              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)                                                             
      Astrocytoma Malignant                                         1 (2%)                                                          
      Oligodendroglioma Malignant                      1 (2%)                                                                       
   Spinal Cord                                        (2)          (4)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)                                                             
      Alveolar/Bronchiolar Adenoma                     2 (3%)       2 (3%)                                                          
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                                                              
      Carcinoma                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)                                                             
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (59)         (60)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)                                                             
      Leukemia Mononuclear                            27 (45%)     37 (62%)                                                         
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   4                                                               
NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            

   Multiple Organs                                   *(60)        *(60)                                                             
      Mesothelioma Malignant                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

                                                             Page   5                                                               
NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            59          59                                                               
     Total Primary Neoplasms                          164         133                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 52          46                                                               
     Total Benign Neoplasms                           112          88                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              41          40                                                               
     Total Malignant Neoplasms                         52          45                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          5                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           70                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                48           41                                                               
    Natural Death                                      4            6                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                              2                                                               
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                 8           10                                                               

  Animals Examined Microscopically                    60           60                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (58)         (60)                                                             
   Intestine Large, Cecum                             (60)         (60)                                                             
   Intestine Small, Duodenum                          (60)         (60)                                                             
   Intestine Small, Jejunum                           (60)         (60)                                                             
      Leiomyosarcoma                                                1 (2%)                                                          
   Intestine Small, Ileum                             (60)         (60)                                                             
   Liver                                              (60)         (60)                                                             
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Hepatocellular Adenoma                           4 (7%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Mesentery                                          (20)         (8)                                                              
      Histiocytic Sarcoma                              1 (5%)                                                                       
      Schwannoma Malignant                             1 (5%)                                                                       
   Oral Mucosa                                        (1)                                                                           
      Squamous Cell Carcinoma                          1 (100%)                                                                     
   Pancreas                                           (60)         (58)                                                             
      Acinus, Adenoma                                  3 (5%)                                                                       
   Salivary Glands                                    (60)         (60)                                                             
   Stomach, Forestomach                               (60)         (60)                                                             
   Stomach, Glandular                                 (60)         (60)                                                             
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Carcinoma                          1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)                                                             
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)                                                             
      Adenoma                                          1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
   Adrenal Medulla                                    (60)         (59)                                                             
      Pheochromocytoma Malignant                       1 (2%)       2 (3%)                                                          
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                         13 (22%)      7 (12%)                                                         
      Pheochromocytoma Benign, Multiple                1 (2%)       5 (8%)                                                          
   Islets, Pancreatic                                 (60)         (58)                                                             
      Adenoma                                          5 (8%)       2 (3%)                                                          
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (60)         (57)                                                             
      Pars Distalis, Adenoma                          19 (32%)     13 (23%)                                                         
   Thyroid Gland                                      (60)         (60)                                                             
      C-Cell, Adenoma                                  5 (8%)       7 (12%)                                                         
      Follicular Cell, Carcinoma                                    2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)          (3)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (60)         (60)                                                             
      Adenoma                                          5 (8%)       1 (2%)                                                          
      Carcinoma                                        2 (3%)       1 (2%)                                                          
   Prostate                                           (60)         (60)                                                             
      Adenoma                                          2 (3%)                                                                       
   Seminal Vesicle                                    (60)         (60)                                                             
   Testes                                             (60)         (60)                                                             
      Bilateral, Interstitial Cell, Adenoma           42 (70%)     52 (87%)                                                         
      Interstitial Cell, Adenoma                      13 (22%)      7 (12%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)                                                             
   Lymph Node                                         (33)         (36)                                                             
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (3%)                                                          
   Lymph Node, Mandibular                             (60)         (60)                                                             
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
   Lymph Node, Mesenteric                             (60)         (60)                                                             
   Spleen                                             (60)         (60)                                                             

                                                             Page   8                                                               
NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Fibroma                                          2 (3%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
   Thymus                                             (58)         (54)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (58)                                                             
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                     1 (2%)                                                          
      Fibroadenoma                                     9 (16%)      4 (7%)                                                          
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (60)         (60)                                                             
      Basal Cell Carcinoma                             1 (2%)       1 (2%)                                                          
      Keratoacanthoma                                  3 (5%)       1 (2%)                                                          
      Keratoacanthoma, Multiple                        1 (2%)                                                                       
      Squamous Cell Papilloma                          2 (3%)                                                                       
      Trichoepithelioma                                2 (3%)                                                                       
      Sebaceous Gland, Adenoma                         1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     3 (5%)       6 (10%)                                                         
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Benign           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)                                                             
      Astrocytoma Malignant                            1 (2%)                                                                       
      Oligodendroglioma Malignant                      1 (2%)                                                                       
   Spinal Cord                                        (2)          (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)                                                             
      Alveolar/Bronchiolar Adenoma                     3 (5%)       1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       

                                                             Page   9                                                               
NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
   Nose                                               (60)         (60)                                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (2)                                                                           
      Carcinoma                                        2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)                                                             
      Lipoma                                           1 (2%)                                                                       
      Renal Tubule, Adenoma                            2 (3%)                                                                       
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
   Urinary Bladder                                    (60)         (60)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)                                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            39 (65%)     46 (77%)                                                         
      Lymphoma Malignant                               1 (2%)                                                                       
      Mesothelioma Malignant                           1 (2%)       3 (5%)                                                          
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05217-99  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 04/10/95  
Route: DOSED FEED                                                                                                 Time: 14:53:49  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     UNTREATD     RTD UNTR                                                            
                                                    CONTROL     CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            60          59                                                               
     Total Primary Neoplasms                          207         166                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 60          59                                                               
     Total Benign Neoplasms                           148         107                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              51          52                                                               
     Total Malignant Neoplasms                         59          59                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1                                                               
     Total Metastatic Neoplasm                                      5                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  11                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.