TDMS Study 05217-99 Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
T-BUTYLHYDROQUINONE
NTP Experiment-Test: 05217-99 Report: PEIRPT05
Study Type: CHRONIC Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
05217/03 -VS- 05217/04 COMPARISON
Facility: SOUTHERN RESEARCH INSTITUTE
Chemical CAS #: 1948-33-0
Lock Date: 05/26/93
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 UNTREATD CONTROL
Include 002 UNTREATD CONTROL
Include 005 RTD UNTRCONTROL
Include 006 RTD UNTRCONTROL
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70
Early Deaths
Moribund Sacrifice 40 39
Natural Death 10 3
Survivors
Terminal Sacrifice 10 18
Animals Examined Microscopically 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Ileum (60) (60)
Liver (60) (60)
Hepatocellular Adenoma 1 (2%)
Mesentery (11) (8)
Sarcoma Stromal, Metastatic, Uterus 1 (9%)
Pancreas (60) (60)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Salivary Glands (60) (60)
Stomach, Forestomach (60) (59)
Stomach, Glandular (60) (59)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60)
Adenoma 4 (7%)
Adrenal Medulla (60) (57)
Pheochromocytoma Benign 2 (3%) 3 (5%)
Pheochromocytoma Benign, Multiple 1 (2%)
Islets, Pancreatic (60) (60)
Adenoma 2 (3%) 1 (2%)
Parathyroid Gland (52) (55)
Adenoma 2 (4%)
Pituitary Gland (60) (59)
Pars Distalis, Adenoma 26 (43%) 30 (51%)
Pars Distalis, Carcinoma 2 (3%)
Page 2
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Thyroid Gland (60) (60)
C-Cell, Adenoma 7 (12%) 3 (5%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (58) (59)
Adenoma 6 (10%) 3 (5%)
Carcinoma 6 (10%) 2 (3%)
Ovary (60) (60)
Granulosa Cell Tumor Malignant 1 (2%)
Granulosa Cell Tumor Benign 1 (2%) 2 (3%)
Uterus (60) (60)
Leiomyoma 1 (2%)
Polyp Stromal 6 (10%) 8 (13%)
Polyp Stromal, Multiple 1 (2%)
Sarcoma Stromal 2 (3%)
Vagina (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60)
Lymph Node (20) (19)
Lymph Node, Mandibular (59) (60)
Lymph Node, Mesenteric (58) (59)
Spleen (60) (60)
Hemangiosarcoma 1 (2%)
Thymus (56) (57)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (60) (60)
Adenoma 3 (5%)
Carcinoma 8 (13%) 1 (2%)
Fibroadenoma 28 (47%) 22 (37%)
Fibroadenoma, Multiple 15 (25%) 8 (13%)
Page 3
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Skin (60) (60)
Basal Cell Carcinoma 1 (2%) 1 (2%)
Trichoepithelioma 1 (2%)
Subcutaneous Tissue, Fibroma 3 (5%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1) (1)
Sarcoma Stromal, Metastatic, Uterus 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60)
Astrocytoma Malignant 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (2) (4)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60)
Alveolar/Bronchiolar Adenoma 2 (3%) 2 (3%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (59) (60)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60)
Leukemia Mononuclear 27 (45%) 37 (62%)
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(60) *(60)
Mesothelioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 59 59
Total Primary Neoplasms 164 133
Total Animals with Benign Neoplasms 52 46
Total Benign Neoplasms 112 88
Total Animals with Malignant Neoplasms 41 40
Total Malignant Neoplasms 52 45
Total Animals with Metastatic Neoplasms 2
Total Metastatic Neoplasm 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 70 70
Early Deaths
Moribund Sacrifice 48 41
Natural Death 4 6
Survivors
Moribund Sacrifice 2
Natural Death 1
Terminal Sacrifice 8 10
Animals Examined Microscopically 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (58) (60)
Intestine Large, Cecum (60) (60)
Intestine Small, Duodenum (60) (60)
Intestine Small, Jejunum (60) (60)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (60) (60)
Liver (60) (60)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Hepatocellular Adenoma 4 (7%)
Histiocytic Sarcoma 1 (2%)
Mesentery (20) (8)
Histiocytic Sarcoma 1 (5%)
Schwannoma Malignant 1 (5%)
Oral Mucosa (1)
Squamous Cell Carcinoma 1 (100%)
Pancreas (60) (58)
Acinus, Adenoma 3 (5%)
Salivary Glands (60) (60)
Stomach, Forestomach (60) (60)
Stomach, Glandular (60) (60)
Tongue (1) (1)
Squamous Cell Carcinoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60)
Adenoma 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Adrenal Medulla (60) (59)
Pheochromocytoma Malignant 1 (2%) 2 (3%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 13 (22%) 7 (12%)
Pheochromocytoma Benign, Multiple 1 (2%) 5 (8%)
Islets, Pancreatic (60) (58)
Adenoma 5 (8%) 2 (3%)
Carcinoma 1 (2%)
Pituitary Gland (60) (57)
Pars Distalis, Adenoma 19 (32%) 13 (23%)
Thyroid Gland (60) (60)
C-Cell, Adenoma 5 (8%) 7 (12%)
Follicular Cell, Carcinoma 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (3)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (60) (60)
Adenoma 5 (8%) 1 (2%)
Carcinoma 2 (3%) 1 (2%)
Prostate (60) (60)
Adenoma 2 (3%)
Seminal Vesicle (60) (60)
Testes (60) (60)
Bilateral, Interstitial Cell, Adenoma 42 (70%) 52 (87%)
Interstitial Cell, Adenoma 13 (22%) 7 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60)
Lymph Node (33) (36)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (3%)
Lymph Node, Mandibular (60) (60)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mesenteric (60) (60)
Spleen (60) (60)
Page 8
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Fibroma 2 (3%)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Thymus (58) (54)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57) (58)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Fibroadenoma 9 (16%) 4 (7%)
Fibroadenoma, Multiple 1 (2%)
Skin (60) (60)
Basal Cell Carcinoma 1 (2%) 1 (2%)
Keratoacanthoma 3 (5%) 1 (2%)
Keratoacanthoma, Multiple 1 (2%)
Squamous Cell Papilloma 2 (3%)
Trichoepithelioma 2 (3%)
Sebaceous Gland, Adenoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 3 (5%) 6 (10%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Hemangiosarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60)
Astrocytoma Malignant 1 (2%)
Oligodendroglioma Malignant 1 (2%)
Spinal Cord (2) (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60)
Alveolar/Bronchiolar Adenoma 3 (5%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Histiocytic Sarcoma 1 (2%)
Page 9
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Nose (60) (60)
Squamous Cell Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2)
Carcinoma 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60)
Lipoma 1 (2%)
Renal Tubule, Adenoma 2 (3%)
Transitional Epithelium, Carcinoma 1 (2%)
Urinary Bladder (60) (60)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 39 (65%) 46 (77%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 1 (2%) 3 (5%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05217-99 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 04/10/95
Route: DOSED FEED Time: 14:53:49
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD RTD UNTR
CONTROL CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 60 59
Total Primary Neoplasms 207 166
Total Animals with Benign Neoplasms 60 59
Total Benign Neoplasms 148 107
Total Animals with Malignant Neoplasms 51 52
Total Malignant Neoplasms 59 59
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 11
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------