TDMS Study 05217-03 Pathology Tables
NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
T-BUTYLHYDROQUINONE
NTP Experiment-Test: 05217-03 Report: PEIRPT09
Study Type: CHRONIC Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
RTD FEED CORE STUDY COMPARISON
Facility: Southern Research Institute
Chemical CAS #: 1948-33-0
Lock Date: 05/26/93
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 007 0.5%
Include 008 0.5%
Include 009 0.0%
Include 010 0.0%
Page 1
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|
DAY ON TEST | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|
| 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Parasite Metazoan | X X X |
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 3 1 2 2 1 1 3 1 3 1 2 1 2 2|
Clear Cell Focus | 1 2|
Degeneration, Cystic | |
Eosinophilic Focus | 3 4 4 3 3 2 2|
Eosinophilic Focus, Multiple | 3 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X X X X X X X X X X|
Inflammation, Granulomatous | 1 1 1 1 2 2|
Mixed Cell Focus | 2 3 2 |
Necrosis, Focal | 1 2 1 |
Bile Duct, Cyst | 4 |
Bile Duct, Hyperplasia | 1 2 3 3 1 3 1 1 1 2 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Pigmentation | 2 2 3 2 1 |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X X |
Fat, Necrosis | 2 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy | 3 3 1 2 1 |
Acinus, Cytoplasmic Alteration | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia | 4 |
Ulcer | 4 |
Mucosa, Hyperplasia | 3 2 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|
DAY ON TEST | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|
| 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 3 1 3 2 1 2 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 3 2 2 |
Degeneration, Fatty | 3 2 1 4 3 3 3 2 |
Hemorrhage | 3 |
Hyperplasia, Diffuse | 3 |
Hyperplasia, Focal | |
Hypertrophy, Focal | 3 2 2 3 2 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + M + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 4 2 |
Pars Distalis, Cyst | 3 3 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 3 1 2 2 |
Pars Intermedia, Cyst | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | 3 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
Hyperplasia | 2 2 |
Inflammation, Chronic | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|
DAY ON TEST | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|
| 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hydrometra | 3 2 2 |
Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Vagina | M M M + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Mediastinal, Pigmentation | 3 |
Pancreatic, Pigmentation | 3 3 3 |
Renal, Hemorrhage | 2 2 |
Renal, Pigmentation | 3 3 3 4 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 2 2 2 2 2 2 |
Hyperplasia, Plasma Cell | |
Pigmentation | 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 3 2 2 3 |
Hyperplasia, Lymphoid | |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 2 1 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
Metaplasia, Lipocyte | 2 |
Necrosis | 2 |
Pigmentation, Hemosiderin | 3 3 3 3 2 2 2 3 2 3 3 2 2 2 2 3|
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 2 2 2 2 3 2 2 2 3 3 1 2 2 2|
Galactocele | 4 |
Hyperplasia | 3 3 3 1 3 3 2 |
Inflammation, Suppurative | 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | 2 |
Epidermis, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|
DAY ON TEST | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|
| 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 4 |
Hyperostosis | |
Cranium, Osteopetrosis | 3 3 3 |
Femur, Osteopetrosis | 3 3 2 |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 3 2 4|
Hemorrhage | 3 |
Hydrocephalus | 2 3|
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 3 2 1 1 2 1 2 2 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 2 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 2 |
Goblet Cell, Hyperplasia | 1 1 1 1 |
Mucosa, Hyperplasia | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 4 |
Retina, Degeneration | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Inflammation, Chronic | 2 |
Mineralization | 1 2 1 2 1 2 2 2 2 1 1 2 2 1 2 1 2 2 2|
Nephropathy | 1 1 2 1 4 1 2 2 1 1 4 2 3 3 1 1 2|
Renal Tubule, Atrophy | 2 1 |
Renal Tubule, Cytoplasmic Alteration | 2 |
Renal Tubule, Dilatation | |
Renal Tubule, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|
DAY ON TEST | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|
| 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Pigmentation | 3 3 2 2 2 1|
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|
DAY ON TEST | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|
| 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + M + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
Ulcer | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + M M + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 3 2 2 1 1 3 2 1 1 2 2|
Clear Cell Focus | 4 |
Degeneration, Cystic | |
Eosinophilic Focus | 3 2 3 3 3 3 3 3|
Eosinophilic Focus, Multiple | |
Hematopoietic Cell Proliferation | 1 1|
Hepatodiaphragmatic Nodule | X X X X X X |
Inflammation, Granulomatous | 1 1 |
Mixed Cell Focus | 1 2 1 |
Necrosis, Focal | |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 2 3 1 2 1 3 1 1 1 |
Centrilobular, Necrosis | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 4 |
Kupffer Cell, Pigmentation | 2 2 1 |
__________________________________________________________________________|
Mesentery | + + + |
Accessory Spleen | |
Fat, Necrosis | 1 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 1 2 |
Acinus, Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia | |
Ulcer | 3 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|
DAY ON TEST | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|
| 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 2 1 1 1 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 2|
Degeneration, Fatty | 3 |
Hemorrhage | |
Hyperplasia, Diffuse | |
Hyperplasia, Focal | |
Hypertrophy, Focal | 1 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + M M + M + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 3 |
Pars Distalis, Cyst | 3 3 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 3 1 |
Pars Intermedia, Cyst | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
C-Cell, Hyperplasia | 2 1 1 2 4|
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 |
Hyperplasia | 3 |
Inflammation, Chronic | 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|
DAY ON TEST | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|
| 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hydrometra | 3 2 2 2 |
Hyperplasia, Cystic | |
__________________________________________________________________________|
Vagina | M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Myelofibrosis | 1 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + |
Mediastinal, Pigmentation | 3 3 3 3 |
Pancreatic, Pigmentation | 4 |
Renal, Hemorrhage | |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hyperplasia, Lymphoid | 2|
Hyperplasia, Plasma Cell | 2 |
Pigmentation | 2 2 3 2 2 2 2 2 2 3 2 2 2 3|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2|
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 3 2 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 1 3 2 2 3|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Metaplasia, Lipocyte | |
Necrosis | |
Pigmentation, Hemosiderin | 3 2 3 3 3 2 2 2 2 2 2 3 3 2 3 1 2 2|
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + M + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 2 2 1 2 1 2 2 3 1 2 2 2 2 2 |
Galactocele | 3 3 3|
Hyperplasia | 3 2 1 2 1 3 |
Inflammation, Suppurative | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Ulcer | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|
DAY ON TEST | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|
| 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Hyperostosis | |
Cranium, Osteopetrosis | 3 2 3 |
Femur, Osteopetrosis | 2 3 |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 4 4 2 3 2 3 4 3 2 4|
Hemorrhage | |
Hydrocephalus | 2 2 2 3 2 2|
__________________________________________________________________________|
Peripheral Nerve | + +|
__________________________________________________________________________|
Spinal Cord | + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Goblet Cell, Hyperplasia | 2 |
Mucosa, Hyperplasia | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | +|
__________________________________________________________________________|
Eye | |
Cataract | |
Retina, Degeneration | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | 2 2 2 |
Mineralization | 3 1 1 1 1 1 2 1 1 1 1 2 2 2 2 2 2 1 2 2 2 2|
Nephropathy | 1 1 1 2 2 1 1 2 1 1 2 1 3 2|
Renal Tubule, Atrophy | 2 3 |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|
DAY ON TEST | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|
| 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.5% | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Pigmentation | 2 1 2 2 2 2 2 2|
Transitional Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 1 1 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 6| 8| 8| | |
DAY ON TEST | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9| | |
| 8| 8| 8| 8| 4| 1| 0| 1| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
Edema | | 1 3.0|
Parasite Metazoan | X | 5 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + I + | 59 |
Parasite Metazoan | | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Edema | | 2 2.5|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus | 2 2 2 2 | 29 1.8|
Clear Cell Focus | 1 1 | 5 1.8|
Degeneration, Cystic | 1 | 1 1.0|
Eosinophilic Focus | 3 3 | 17 2.9|
Eosinophilic Focus, Multiple | | 1 3.0|
Hematopoietic Cell Proliferation | | 2 1.0|
Hepatodiaphragmatic Nodule | X X | 18 |
Inflammation, Granulomatous | 1 1 | 10 1.2|
Mixed Cell Focus | 3 | 7 2.0|
Necrosis, Focal | | 3 1.3|
Bile Duct, Cyst | | 1 4.0|
Bile Duct, Hyperplasia | 1 1 2 1 1 | 24 1.6|
Centrilobular, Necrosis | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 3 3.3|
Kupffer Cell, Pigmentation | 2 | 9 1.9|
__________________________________________________________________________|____________|
Mesentery | | 7 |
Accessory Spleen | | 2 |
Fat, Necrosis | | 5 2.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Atrophy | 3 2 4 | 13 2.0|
Acinus, Cytoplasmic Alteration | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Erosion | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 6| 8| 8| | |
DAY ON TEST | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9| | |
| 8| 8| 8| 8| 4| 1| 0| 1| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | | 1 4.0|
Ulcer | | 2 3.5|
Mucosa, Hyperplasia | 1 3 | 5 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Erosion | | 2 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 | 28 1.9|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 2 1 | 9 1.9|
Degeneration, Fatty | 3 2 1 | 12 2.5|
Hemorrhage | | 1 3.0|
Hyperplasia, Diffuse | | 1 3.0|
Hyperplasia, Focal | 1 4 | 2 2.5|
Hypertrophy, Focal | | 7 2.1|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 7 1.6|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 54 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Pars Distalis, Angiectasis | 4 4 | 7 3.1|
Pars Distalis, Cyst | 3 3 3 3 3 3 3 | 19 3.0|
Pars Distalis, Hyperplasia, Focal | 3 1 3 | 9 2.1|
Pars Intermedia, Cyst | | 3 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 1 3.0|
C-Cell, Hyperplasia | 1 | 8 1.9|
Follicle, Cyst | | 1 3.0|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 6| 8| 8| | |
DAY ON TEST | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9| | |
| 8| 8| 8| 8| 4| 1| 0| 1| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 60 |
Cyst | | 5 3.0|
Hyperplasia | 2 | 4 2.3|
Inflammation, Chronic | 2 | 2 2.5|
Inflammation, Suppurative | | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | 3 3 3 3 | 17 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | | 7 2.3|
Hyperplasia, Cystic | 1 | 3 1.3|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Fibrosis | 2 | 1 2.0|
Myelofibrosis | 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node | + + | 18 |
Mediastinal, Pigmentation | 3 | 6 3.0|
Pancreatic, Pigmentation | | 4 3.3|
Renal, Hemorrhage | | 2 2.0|
Renal, Pigmentation | 3 | 7 3.1|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Ectasia | | 1 2.0|
Hyperplasia, Lymphoid | | 7 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Pigmentation | 2 2 2 2 | 25 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Ectasia | | 2 2.5|
Hemorrhage | 2 | 7 2.3|
Hyperplasia, Lymphoid | 2 | 4 2.3|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 2 | 3 2.0|
Hematopoietic Cell Proliferation | 2 1 | 11 2.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | | 1 3.0|
Metaplasia, Lipocyte | | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation, Hemosiderin | 3 2 2 2 2 2 3 | 41 2.4|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 6| 8| 8| | |
DAY ON TEST | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9| | |
| 8| 8| 8| 8| 4| 1| 0| 1| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 2 2 2 2 | 34 2.0|
Galactocele | 4 | 5 3.4|
Hyperplasia | 2 2 | 15 2.3|
Inflammation, Suppurative | | 1 4.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Ulcer | 1 | 2 1.5|
Epidermis, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 1 4.0|
Hyperostosis | 3 | 1 3.0|
Cranium, Osteopetrosis | 2 2 2 | 9 2.6|
Femur, Osteopetrosis | | 5 2.6|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Atrophy | 3 3 | 22 3.0|
Hemorrhage | | 1 3.0|
Hydrocephalus | | 8 2.3|
__________________________________________________________________________|____________|
Peripheral Nerve | + | 4 |
__________________________________________________________________________|____________|
Spinal Cord | + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Hemorrhage | | 2 1.0|
Infiltration Cellular, Histiocyte | | 23 1.3|
Alveolar Epithelium, Hyperplasia | 1 | 4 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 2 | 3 1.7|
Goblet Cell, Hyperplasia | 1 | 6 1.2|
Mucosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 8| 8| 7| 8| 6| 6| 8| 8| | |
DAY ON TEST | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9| | |
| 8| 8| 8| 8| 4| 1| 0| 1| 9| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | | 1 |
Cataract | | 1 4.0|
Retina, Degeneration | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 2 3.0|
Inflammation, Chronic | 2 | 5 2.0|
Mineralization | 2 2 1 2 2 2 2 | 48 1.6|
Nephropathy | 2 3 2 2 2 1 2 3 | 39 1.8|
Renal Tubule, Atrophy | 1 | 5 1.8|
Renal Tubule, Cytoplasmic Alteration | 3 | 2 2.5|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Necrosis | | 2 3.5|
Renal Tubule, Pigmentation | 3 2 | 16 2.1|
Transitional Epithelium, Hyperplasia | | 3 1.3|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Transitional Epithelium, Hyperplasia | | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|
DAY ON TEST | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|
| 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 3 2 3 2 3 2 4 4 2 3 3 1 3|
Clear Cell Focus | 3 2 |
Degeneration, Cystic | |
Eosinophilic Focus | 3 3 3 3|
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X X X X X |
Inflammation, Granulomatous | 1 3|
Mixed Cell Focus | 4|
Necrosis, Focal | |
Bile Duct, Hyperplasia | 1 2 3 1 1 |
Centrilobular, Atrophy | 2 |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
Kupffer Cell, Pigmentation | 2 2 2 3 |
__________________________________________________________________________|
Mesentery | + + + + |
Accessory Spleen | X X |
Fat, Necrosis | 3 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 1 1 1 2 |
Acinus, Cytoplasmic Alteration | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Chronic | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Ulcer | 2 1 |
Mucosa, Hyperplasia | 3 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Erosion | |
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|
DAY ON TEST | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|
| 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 1 2 2 1 2 3 3 2 1 3 2 2 3 2 |
Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 |
Degeneration, Fatty | 4 3 3 |
Fibrosis | |
Hyperplasia, Focal | 2 3 |
Hypertrophy, Focal | 3 1 2 |
Necrosis | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 2 1 2 |
Pars Distalis, Atypia Cellular | |
Pars Distalis, Cyst | 3 3 3 3 3|
Pars Distalis, Hyperplasia, Focal | 2 2 3 1 |
Pars Intermedia, Angiectasis | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Ultimobranchial Cyst | 3 |
C-Cell, Hyperplasia | 3 1 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | 3 3 3 |
Fibrosis | |
Hyperplasia | 2 2 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|
DAY ON TEST | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|
| 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 3 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 2 |
Hyperplasia, Cystic | 2 1 |
__________________________________________________________________________|
Vagina | M M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Myelofibrosis | |
Stromal Cell, Hyperplasia | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Iliac, Hemorrhage | 1 |
Iliac, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hemorrhage | |
Mediastinal, Pigmentation | 3 2 |
Pancreatic, Pigmentation | |
Renal, Pigmentation | 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 2 2 2 2 2 3|
Pigmentation | 2 2 2 2 2 2 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hemorrhage | 2 2 2 |
Hyperplasia, Lymphoid | 3 |
Pigmentation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 |
Hematopoietic Cell Proliferation | 2 3 1 3 1 |
Pigmentation, Hemosiderin | 2 3 2 3 2 3 2 2 3 2 |
Red Pulp, Atrophy | 4 |
__________________________________________________________________________|
Thymus | + + + + + I + + + + + + + + + + + + + + + + I + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 1 1 3 2 3 4 2 1 2 1 3 2 2 3|
Galactocele | 3 |
Hyperplasia | 3 3 2 2 1 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperkeratosis | 2 |
Inflammation, Chronic | 2 |
Ulcer | |
Epidermis, Hyperplasia | 2 3 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|
DAY ON TEST | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|
| 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 3 3 2 3 3|
Femur, Osteopetrosis | 3 3 3 2 2 3 3|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 3 3 |
Gliosis | 3 |
Hydrocephalus | 3 |
Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 2 2 1 1 2 1 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X|
Inflammation, Suppurative | 2 2|
Goblet Cell, Hyperplasia | 1 1 1 1|
Mucosa, Hyperplasia | 2|
Mucosa, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Inflammation, Chronic | |
Inflammation, Suppurative | |
Mineralization | 2 2 2 2 2 1 1 2 1 1 2 2 2 3 1 1 1 2 2 2 2 1|
Nephropathy | 2 1 2 2 1 1 2 1 2 2 1|
Renal Tubule, Atrophy | 3 |
Renal Tubule, Cytoplasmic Alteration | 3 2 |
Renal Tubule, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|
DAY ON TEST | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|
| 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Pigmentation | 2 2 2 |
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|
DAY ON TEST | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|
| 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2|
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 3 1 1 4 2 2 2 3 2 3 3 3 4 1 |
Clear Cell Focus | 1 2 |
Degeneration, Cystic | 3 |
Eosinophilic Focus | 3 3 3 3 3 3 |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | X X X X X X X |
Inflammation, Granulomatous | 1 1 1 |
Mixed Cell Focus | 3 |
Necrosis, Focal | 3 1 |
Bile Duct, Hyperplasia | 3 2 3 1 1 2 2 1 2 1 2|
Centrilobular, Atrophy | |
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 4 3 3 3|
Kupffer Cell, Pigmentation | 3 3 3 2 3|
__________________________________________________________________________|
Mesentery | +|
Accessory Spleen | X|
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2 2 2 1 2 1 1 2|
Acinus, Cytoplasmic Alteration | 3 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 4 |
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 3 2 |
Ulcer | 4 |
Mucosa, Hyperplasia | 1 3 4 3 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 3 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|
DAY ON TEST | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|
| 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 1 1 3 2 1 3 2 2 1 2|
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 1 1 |
Degeneration, Fatty | 2 2 1 |
Fibrosis | 2 |
Hyperplasia, Focal | 2 2 1 |
Hypertrophy, Focal | 3 2|
Necrosis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + M M + + + + + + + + + + + + I + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Pars Distalis, Angiectasis | 2 3|
Pars Distalis, Atypia Cellular | 2 |
Pars Distalis, Cyst | 3 3 3 3|
Pars Distalis, Hyperplasia, Focal | 2 3 |
Pars Intermedia, Angiectasis | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 |
C-Cell, Hyperplasia | 3 3 1 1 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Fibrosis | |
Hyperplasia | 3 |
Inflammation, Chronic | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|
DAY ON TEST | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|
| 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Cyst | 3 3 3 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 2 3 2 |
Hyperplasia, Cystic | 1 |
__________________________________________________________________________|
Vagina | M M M |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Myelofibrosis | 4 |
Stromal Cell, Hyperplasia | 4 |
__________________________________________________________________________|
Lymph Node | + + + + +|
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Pigmentation | 3|
Pancreatic, Pigmentation | 3 3|
Renal, Pigmentation | 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
Hemorrhage | 2 1 |
Hyperplasia, Lymphoid | 2 2 2 2 2 |
Pigmentation | 2 2 2 2 2 2 2 2 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 |
Pigmentation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 3 |
Hematopoietic Cell Proliferation | 2 3 3 3 2 |
Pigmentation, Hemosiderin | 2 3 2 3 2 3 3 3 2 2 3 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 4 3 2 2 2 3 3 2 2 3 2 2 |
Galactocele | |
Hyperplasia | 3 3 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | 4 |
Ulcer | 2 4 |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|
DAY ON TEST | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|
| 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cranium, Osteopetrosis | 2 4 2 3 2 3 3 2|
Femur, Osteopetrosis | 4 3 2 2 3 4 3|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 4 4 2 3 2 4 4 3|
Gliosis | |
Hydrocephalus | 3 2 |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 2 2 1 3 1 1 1 2 1 1 4 1 2 1 |
Inflammation, Subacute | 4 |
Alveolar Epithelium, Hyperplasia | 1 1 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | |
Goblet Cell, Hyperplasia | 1 1 |
Mucosa, Hyperplasia | |
Mucosa, Metaplasia, Squamous | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Inflammation, Chronic | 4 |
Inflammation, Suppurative | 2 |
Mineralization | 3 2 1 1 2 1 2 1 1 1 2 2 2 2 2 3 2 2 2 2 2 2|
Nephropathy | 1 3 1 1 2 2 3 2 2 2 1 2 2 1 1 3 1 1 1|
Renal Tubule, Atrophy | |
Renal Tubule, Cytoplasmic Alteration | |
Renal Tubule, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|
DAY ON TEST | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|
| 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
0.0% | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Renal Tubule, Pigmentation | 2 2 2 2 2|
Transitional Epithelium, Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 8| 8| 6| 7| 8| 5| | |
DAY ON TEST | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2| | |
| 8| 0| 0| 9| 9| 9| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Inflammation, Subacute | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Parasite Metazoan | | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 1 | 2 2.0|
Basophilic Focus | 3 2 3 3 2 2 2 | 34 2.5|
Clear Cell Focus | | 4 2.0|
Degeneration, Cystic | | 1 3.0|
Eosinophilic Focus | 3 2 | 12 2.9|
Hematopoietic Cell Proliferation | | 3 1.3|
Hepatodiaphragmatic Nodule | | 12 |
Inflammation, Granulomatous | 1 2 2 3 | 9 1.7|
Mixed Cell Focus | 3 | 3 3.3|
Necrosis, Focal | | 2 2.0|
Bile Duct, Hyperplasia | 3 1 | 18 1.8|
Centrilobular, Atrophy | | 1 2.0|
Centrilobular, Necrosis | | 1 3.0|
Hepatocyte, Vacuolization Cytoplasmic| | 7 3.1|
Kupffer Cell, Pigmentation | | 9 2.6|
__________________________________________________________________________|____________|
Mesentery | | 5 |
Accessory Spleen | | 3 |
Fat, Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 2 1 1 3 | 20 1.7|
Acinus, Cytoplasmic Alteration | | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Cyst | | 1 4.0|
Inflammation, Chronic | | 1 4.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | 3 | 2 2.5|
Erosion | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 8| 8| 6| 7| 8| 5| | |
DAY ON TEST | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2| | |
| 8| 0| 0| 9| 9| 9| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Ulcer | 3 | 4 2.5|
Mucosa, Hyperplasia | 2 | 9 2.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Erosion | | 1 3.0|
Ulcer | | 4 2.8|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 3 1 2 | 35 1.9|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 1 | 8 1.5|
Degeneration, Fatty | 1 1 | 8 2.1|
Fibrosis | | 1 2.0|
Hyperplasia, Focal | 1 | 6 1.8|
Hypertrophy, Focal | 1 2 1 | 8 1.9|
Necrosis | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 | 7 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | 3 | 7 2.3|
Pars Distalis, Atypia Cellular | | 1 2.0|
Pars Distalis, Cyst | 3 3 | 11 3.0|
Pars Distalis, Hyperplasia, Focal | 3 | 7 2.3|
Pars Intermedia, Angiectasis | | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Ultimobranchial Cyst | | 2 3.0|
C-Cell, Hyperplasia | 1 3 | 9 1.9|
Follicular Cell, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 8| 8| 6| 7| 8| 5| | |
DAY ON TEST | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2| | |
| 8| 0| 0| 9| 9| 9| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Cyst | | 5 3.0|
Fibrosis | 3 | 1 3.0|
Hyperplasia | 2 | 4 2.3|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Angiectasis | 2 | 1 2.0|
Cyst | 3 3 | 9 3.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | | 5 2.2|
Hyperplasia, Cystic | 3 | 4 1.8|
__________________________________________________________________________|____________|
Vagina | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 1 3.0|
Myelofibrosis | | 1 4.0|
Stromal Cell, Hyperplasia | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node | + | 14 |
Iliac, Hemorrhage | | 1 1.0|
Iliac, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Hemorrhage | | 1 3.0|
Mediastinal, Pigmentation | | 3 2.7|
Pancreatic, Pigmentation | | 2 3.0|
Renal, Pigmentation | 3 | 3 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Ectasia | | 2 2.0|
Hemorrhage | | 3 1.3|
Hyperplasia, Lymphoid | 3 | 12 2.2|
Pigmentation | 3 2 2 2 2 | 27 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 59 |
Hemorrhage | 1 | 4 1.8|
Hyperplasia, Lymphoid | 2 | 4 2.3|
Pigmentation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | | 4 2.5|
Hematopoietic Cell Proliferation | 2 1 | 12 2.2|
Pigmentation, Hemosiderin | 2 2 3 3 3 2 3 | 28 2.5|
Red Pulp, Atrophy | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 8| 8| 6| 7| 8| 5| | |
DAY ON TEST | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2| | |
| 8| 0| 0| 9| 9| 9| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 60 |
Dilatation | 2 2 2 2 2 | 33 2.2|
Galactocele | | 1 3.0|
Hyperplasia | 2 1 2 | 12 2.2|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | | 2 3.0|
Ulcer | | 2 3.0|
Epidermis, Hyperplasia | | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Cranium, Osteopetrosis | 3 2 2 | 17 2.6|
Femur, Osteopetrosis | 3 2 2 | 17 2.8|
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Atrophy | 2 3 3 3 4 4 | 22 3.0|
Gliosis | | 1 3.0|
Hydrocephalus | 2 | 4 2.5|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Edema | | 2 2.0|
Hemorrhage | | 1 3.0|
Infiltration Cellular, Histiocyte | 2 1 2 1 1 1 | 33 1.5|
Inflammation, Subacute | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 3 | 6 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 1 |
Inflammation, Suppurative | 1 | 3 1.7|
Goblet Cell, Hyperplasia | 1 1 | 8 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 8| 8| 6| 7| 8| 5| | |
DAY ON TEST | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2| | |
| 8| 0| 0| 9| 9| 9| 8| 8| 8| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Mucosa, Hyperplasia | | 1 2.0|
Mucosa, Metaplasia, Squamous | | 2 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 1 3.0|
Inflammation, Chronic | | 1 4.0|
Inflammation, Suppurative | | 1 2.0|
Mineralization | 1 1 1 1 2 3 1 1 | 52 1.7|
Nephropathy | 2 1 1 1 2 1 1 1 | 38 1.6|
Renal Tubule, Atrophy | | 1 3.0|
Renal Tubule, Cytoplasmic Alteration | 2 | 3 2.3|
Renal Tubule, Necrosis | | 1 3.0|
Renal Tubule, Pigmentation | 2 | 9 2.0|
Transitional Epithelium, Hyperplasia | | 4 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Transitional Epithelium, Hyperplasia | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|
DAY ON TEST | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|
| 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + M + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 3 |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Ileum | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 4 1 2 |
Basophilic Focus | 1 1 |
Clear Cell Focus | 1 1 |
Degeneration, Cystic | 4 2 |
Eosinophilic Focus | 3 2 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | 2 |
Necrosis, Focal | 2 2 |
Thrombosis | 1 |
Bile Duct, Hyperplasia | 3 4 1 2 3 3 3 3 3 3 4 1|
Centrilobular, Fibrosis | |
Centrilobular, Necrosis | |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 |
Kupffer Cell, Pigmentation | 2 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + +|
Accessory Spleen | X X X|
Fat, Necrosis | 3 3 2 3 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 2 3 2 3 2 1 1 1 |
Acinus, Cytoplasmic Alteration | |
Acinus, Hyperplasia, Focal | 1 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + I + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 2 |
Hyperplasia | 4 1 2 2 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|
DAY ON TEST | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|
| 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | |
Erosion | |
__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperplasia | 3 1 |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 3 2 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 3 2 2 2 2 2 2 3 3 3 1 3 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 1 1 1|
Degeneration, Fatty | 1 1 |
Hemorrhage | |
Hyperplasia, Focal | 3 |
Hypertrophy, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 1 3 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nuclear Alteration | |
Pars Distalis, Cyst | 3 3 3 |
Pars Distalis, Hyperplasia, Focal | 1 3 2 1 3 3 3 |
Pars Intermedia, Angiectasis | |
Pars Intermedia, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 3 |
C-Cell, Hyperplasia | 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3|
Granuloma Sperm | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|
DAY ON TEST | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|
| 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 1 |
Inflammation, Chronic | 2 2 2 2 2 |
Inflammation, Suppurative | 1 4 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 2 2 1 1 2|
Epithelium, Hyperplasia | 2 2 3 1 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | |
Seminiferous Tubule, Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Infiltration Cellular, Histiocyte | |
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | 4 |
Mediastinal, Congestion | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation | 3 3 3 3 3 2 |
Pancreatic, Hyperplasia, Plasma Cell | |
Pancreatic, Pigmentation | 3 |
Renal, Ectasia | 3 |
Renal, Hemorrhage | |
Renal, Pigmentation | 3 3 4 3 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 2 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 2 3 3 2 3 2 |
Pigmentation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 3 3 4 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 3 3 3 2 2 2 |
Hematopoietic Cell Proliferation | 2 3 |
Pigmentation, Hemosiderin | 3 2 2 1|
__________________________________________________________________________|
Thymus | + + + + + M + + + + + M + + + M + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|
DAY ON TEST | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|
| 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Dilatation | 1 2 2 2 |
Galactocele | 2 3 |
Hyperplasia | 1 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Hemorrhage | |
Hyperkeratosis | 3 |
Epidermis, Hyperplasia | 2 |
Subcutaneous Tissue, Thrombosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | |
Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + |
__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 |
Inflammation, Subacute | 3 |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Suppurative | 1 3 2 2 1 |
Goblet Cell, Hyperplasia | 1 1 2 1 1 1 1 |
Mucosa, Hyperplasia | 3 1 2 1|
Mucosa, Metaplasia, Squamous | 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Atrophy | 4 |
Cataract | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | + |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|
DAY ON TEST | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|
| 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Inflammation, Suppurative | 2 1 1 2 1 1 1 |
Mineralization | |
Nephropathy | 1 3 2 3 3 4 2 3 3 2 2 3 3 1 3 4 3 2 1 2 2 3 3 3 2|
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Atrophy | 3 |
Renal Tubule, Pigmentation | 1 2 3 3 2 3 2 3 |
Transitional Epithelium, Hyperplasia | 3 1 2 1 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|
DAY ON TEST | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|
| 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
Hemorrhage | |
Parasite Metazoan | X X X X X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 1 1 3 2 |
Clear Cell Focus | 2 1 1 |
Degeneration, Cystic | 1 1 3 |
Eosinophilic Focus | 1 |
Hepatodiaphragmatic Nodule | X X X |
Mixed Cell Focus | 4 |
Necrosis, Focal | |
Thrombosis | |
Bile Duct, Hyperplasia | 3 3 3 2 2 2 4 |
Centrilobular, Fibrosis | 3 |
Centrilobular, Necrosis | 3 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 2 2 3 1 4 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Accessory Spleen | X |
Fat, Necrosis | 4 3 2 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 1 2 |
Acinus, Cytoplasmic Alteration | 4 3 3 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 2 2 |
Hyperplasia | 2 3 3 3 3 4 |
Ulcer | 4 2 4 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|
DAY ON TEST | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|
| 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Edema | 2 2 2 |
Erosion | 3 |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy | 2 |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 1 3 3 2 3 2 3 1 2 1 3 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 1 2 1 |
Degeneration, Fatty | 1 2 1 2 2 |
Hemorrhage | 3 2 |
Hyperplasia, Focal | 3|
Hypertrophy, Focal | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 1 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia | 3 3 3 3 2 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nuclear Alteration | |
Pars Distalis, Cyst | 3 3 |
Pars Distalis, Hyperplasia, Focal | 2 4 2 2 |
Pars Intermedia, Angiectasis | 3 |
Pars Intermedia, Cyst | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 3|
C-Cell, Hyperplasia | 3 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Peritoneum | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3 3 |
Granuloma Sperm | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|
DAY ON TEST | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|
| 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 |
Inflammation, Chronic | 2 2 2 2 2|
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 1 3 2 2 1 2 3 1 3 3 3|
Epithelium, Hyperplasia | 2 1 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 1 1 |
Seminiferous Tubule, Atrophy | 1 4 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 3 3 2|
Infiltration Cellular, Histiocyte | 2 |
Myelofibrosis | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Congestion | 3 |
Mediastinal, Hemorrhage | 3 3 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation | 3 3 4 3 3 3 4 2 |
Pancreatic, Hyperplasia, Plasma Cell | |
Pancreatic, Pigmentation | 3 |
Renal, Ectasia | |
Renal, Hemorrhage | 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 |
Hemorrhage | 3 2 2 |
Hyperplasia, Lymphoid | 3 2 3 3 3 3 2 2 |
Pigmentation | 2 2 2 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3 3 2 |
Hemorrhage | 3 3 |
Hyperplasia, Lymphoid | 3 2 2 2 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 2 4 |
Hematopoietic Cell Proliferation | 4 1 1 2 1 |
Pigmentation, Hemosiderin | 2 2 2 2 2 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|
DAY ON TEST | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|
| 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Dilatation | 2 2 2 |
Galactocele | |
Hyperplasia | 2 1 2 2|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hemorrhage | 4 |
Hyperkeratosis | |
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 2 3 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3|
Hemorrhage | 2 |
Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | |
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 |
Inflammation, Subacute | |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 2 2 3 2 1 |
Goblet Cell, Hyperplasia | 1 1 1 1 |
Mucosa, Hyperplasia | 2 2 2 1 2 2 |
Mucosa, Metaplasia, Squamous | 2 2 3 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
Atrophy | |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | |
__________________________________________________________________________|
Zymbal's Gland | + + + |
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|
DAY ON TEST | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|
| 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.5% | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 3 3 3 |
Inflammation, Suppurative | 1 1 1 1 1 1 2 1 |
Mineralization | 1 |
Nephropathy | 4 4 3 4 4 4 1 3 3 2 1 3 3 3 3 3 2 2 3 3 3 2 3 3 3|
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Atrophy | |
Renal Tubule, Pigmentation | 2 4 2 3 |
Transitional Epithelium, Hyperplasia | 2 1 2 2 1 1 2 1 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 7| 6| 4| 6| 8| 6| 6| 7| 5| | |
DAY ON TEST | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3| | |
| 0| 9| 1| 7| 5| 7| 1| 5| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Edema | | 1 3.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M + + + + + | 59 |
Edema | | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Parasite Metazoan | X | 8 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Edema | | 3 2.7|
Parasite Metazoan | X | 3 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
Epithelium, Hyperplasia | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 60 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 7 2.0|
Basophilic Focus | 2 | 7 1.6|
Clear Cell Focus | | 5 1.2|
Degeneration, Cystic | | 5 2.2|
Eosinophilic Focus | 3 | 4 2.3|
Hepatodiaphragmatic Nodule | X X | 8 |
Mixed Cell Focus | | 2 3.0|
Necrosis, Focal | | 2 2.0|
Thrombosis | | 1 1.0|
Bile Duct, Hyperplasia | 2 2 2 3 2 3 | 25 2.6|
Centrilobular, Fibrosis | | 1 3.0|
Centrilobular, Necrosis | 1 | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| | 3 2.7|
Kupffer Cell, Pigmentation | 1 | 10 2.1|
__________________________________________________________________________|____________|
Mesentery | + + | 16 |
Accessory Spleen | | 4 |
Fat, Necrosis | 3 3 | 13 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 3 | 15 1.8|
Acinus, Cytoplasmic Alteration | 3 | 4 3.3|
Acinus, Hyperplasia, Focal | | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 7| 6| 4| 6| 8| 6| 6| 7| 5| | |
DAY ON TEST | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3| | |
| 0| 9| 1| 7| 5| 7| 1| 5| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
Edema | | 6 2.7|
Hyperplasia | 3 3 | 12 2.8|
Ulcer | 4 3 | 7 3.4|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | | 3 2.0|
Erosion | | 1 3.0|
__________________________________________________________________________|____________|
Tongue | + | 4 |
Epithelium, Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
Hypertrophy | | 4 2.3|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 2 3 1 | 37 2.1|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 3 1 | 13 1.3|
Degeneration, Fatty | | 7 1.4|
Hemorrhage | | 2 2.5|
Hyperplasia, Focal | 2 | 3 2.7|
Hypertrophy, Focal | | 2 2.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 3 1 | 12 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 58 |
Hyperplasia | 3 3 | 9 2.8|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Nuclear Alteration | 2 | 1 2.0|
Pars Distalis, Cyst | 3 3 | 7 3.0|
Pars Distalis, Hyperplasia, Focal | 1 3 1 | 14 2.2|
Pars Intermedia, Angiectasis | | 1 3.0|
Pars Intermedia, Cyst | | 2 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | 3 | 5 3.0|
C-Cell, Hyperplasia | | 7 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 7| 6| 4| 6| 8| 6| 6| 7| 5| | |
DAY ON TEST | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3| | |
| 0| 9| 1| 7| 5| 7| 1| 5| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Peritoneum | | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | 3 3 | 25 3.0|
Granuloma Sperm | | 1 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Cyst | | 4 3.0|
Hyperplasia | | 2 1.5|
Inflammation, Chronic | 2 2 | 12 2.0|
Inflammation, Suppurative | 1 | 5 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 1 1 2 2 2 | 23 1.9|
Epithelium, Hyperplasia | 1 | 8 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | | 3 1.3|
Seminiferous Tubule, Atrophy | | 5 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Hyperplasia | | 7 2.9|
Infiltration Cellular, Histiocyte | 2 | 2 2.0|
Myelofibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 35 |
Inguinal, Hyperplasia, Lymphoid | | 1 4.0|
Mediastinal, Congestion | 1 | 2 2.0|
Mediastinal, Hemorrhage | | 3 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 2 2.0|
Mediastinal, Pigmentation | 3 3 | 16 3.0|
Pancreatic, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Pancreatic, Pigmentation | 3 | 3 3.0|
Renal, Ectasia | 3 | 2 3.0|
Renal, Hemorrhage | 3 | 2 3.0|
Renal, Pigmentation | 3 | 7 3.3|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 60 |
Ectasia | 2 | 6 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 7| 6| 4| 6| 8| 6| 6| 7| 5| | |
DAY ON TEST | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3| | |
| 0| 9| 1| 7| 5| 7| 1| 5| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 3 2.3|
Hyperplasia, Lymphoid | 3 2 | 17 2.5|
Pigmentation | 2 | 5 2.2|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 60 |
Ectasia | 3 4 | 10 3.1|
Hemorrhage | | 2 3.0|
Hyperplasia, Lymphoid | | 6 2.3|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis | 3 3 | 13 2.7|
Hematopoietic Cell Proliferation | 2 | 8 2.0|
Pigmentation, Hemosiderin | 2 2 | 12 2.1|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Dilatation | 1 2 1 | 10 1.7|
Galactocele | | 2 2.5|
Hyperplasia | | 6 1.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Cyst Epithelial Inclusion | | 1 |
Hemorrhage | | 1 4.0|
Hyperkeratosis | | 1 3.0|
Epidermis, Hyperplasia | | 1 2.0|
Subcutaneous Tissue, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | 3 2 | 7 2.4|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Atrophy | | 3 3.0|
Hemorrhage | | 1 2.0|
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 7| 6| 4| 6| 8| 6| 6| 7| 5| | |
DAY ON TEST | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3| | |
| 0| 9| 1| 7| 5| 7| 1| 5| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5% | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Edema | | 1 2.0|
Hemorrhage | 2 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 1 3 | 14 1.2|
Inflammation, Subacute | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 7 2.1|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 2 |
Inflammation, Suppurative | 1 | 11 1.8|
Goblet Cell, Hyperplasia | 1 1 | 13 1.1|
Mucosa, Hyperplasia | | 10 1.8|
Mucosa, Metaplasia, Squamous | | 7 2.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | | 2 |
Atrophy | | 1 4.0|
Cataract | | 1 3.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
__________________________________________________________________________|____________|
Zymbal's Gland | | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | 3 3 3 3 | 11 3.0|
Inflammation, Suppurative | 1 1 1 2 1 | 20 1.2|
Mineralization | | 1 1.0|
Nephropathy | 4 4 2 2 3 4 3 3 3 3 | 60 2.8|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 | 1 2.0|
Renal Tubule, Atrophy | | 1 3.0|
Renal Tubule, Pigmentation | 2 3 2 | 15 2.5|
Transitional Epithelium, Hyperplasia | 2 2 1 2 1 1 | 21 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|
DAY ON TEST | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|
| 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X X X X|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + + + + + + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + M + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Basophilic Focus | 2 1 1 |
Clear Cell Focus | |
Congestion | |
Degeneration, Cystic | 2 3 3 3 |
Eosinophilic Focus | 2 2 2 |
Hemorrhage | 3 |
Hepatodiaphragmatic Nodule | X X X |
Necrosis, Focal | 2 2 3 |
Thrombosis | 3 |
Bile Duct, Hyperplasia | 3 3 3 2 4 2 3 3 3 2 1 2 3 2 4 1 2 3 3 2 4|
Centrilobular, Necrosis | 3 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 |
Kupffer Cell, Pigmentation | 4 2 1 3 3 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + +|
Accessory Spleen | X X|
Fat, Necrosis | 2 2 3 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 4 1 2 3 2 2 1 3 |
Acinus, Cytoplasmic Alteration | |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Erosion | 2 |
Hyperplasia | 1 2 3 2 |
Inflammation, Subacute | 2 |
Ulcer | 3 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|
DAY ON TEST | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|
| 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 1 1 2 3 1 2 |
Ulcer | 3 2 |
__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 3 2 2 2 3 3 1 3 2 3 3|
Thrombosis | 4 4 3 |
Schwann Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 3 2 2 2 2 2 2|
Degeneration, Fatty | |
Hemorrhage | 3 3 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | 1 3 2 |
Necrosis | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 3 1 3 2 2 1 4 3 1 2 3 1|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pars Distalis, Angiectasis | 2 3 |
Pars Distalis, Cyst | 3 |
Pars Distalis, Hyperplasia, Focal | 1 2 1 2 2 |
Pars Intermedia, Cyst | 3 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 1|
Follicle, Cyst | 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|
DAY ON TEST | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|
| 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | |
Inflammation, Chronic | 1 2 1 2 2 2 2 2|
Inflammation, Suppurative | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 2 3 2 1 2 1 1 2 3 1 2|
Epithelium, Hyperplasia | 2 3 2 2 1 1|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | |
Myelofibrosis | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | 3 3 2 4 3 2 |
Pancreatic, Pigmentation | 3 |
Renal, Pigmentation | 4 4 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 2 2 2 3 |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 3 2 3 2 2 |
Pigmentation | 3 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 3 2 3 |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Fibrosis | 3 3 3 3 4 3|
Hematopoietic Cell Proliferation | 2 3 |
Necrosis | 2 3 3 |
Pigmentation, Hemosiderin | 3 3 2 3 3 2|
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Dilatation | 1 2 2 3 2 2 1 2 1 2 2|
Hyperplasia | 2 2 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|
DAY ON TEST | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|
| 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
Inflammation, Chronic | |
Epidermis, Hyperplasia | |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
Femur, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 4 2 3|
Hydrocephalus | 2 3 |
Necrosis | 2 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 1 1 2 3 1 1|
Alveolar Epithelium, Hyperplasia | 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X X X |
Inflammation, Suppurative | 3 3 2 2 2 2 |
Goblet Cell, Hyperplasia | 1 1 1 |
Mucosa, Hyperplasia | 3 2 2 2 2 |
Mucosa, Metaplasia, Squamous | 2 3 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Inflammation, Chronic | |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|
DAY ON TEST | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|
| 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
0.0% | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 2 |
Nephropathy | 2 2 2 2 2 2 3 2 1 3 2 2 1 1 2 3 3 2 4 2 1 2 3 3|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 |
Renal Tubule, Atrophy | |
Renal Tubule, Necrosis | 3 |
Renal Tubule, Pigmentation | 2 2 2 3 2 2 2 2 2 2 2 2 |
Transitional Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|
DAY ON TEST | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|
| 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | X |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +|
Parasite Metazoan | X X |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Parasite Metazoan | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 |
Basophilic Focus | 2 1 2 |
Clear Cell Focus | |
Congestion | 3 |
Degeneration, Cystic | 1 1 3 2 1|
Eosinophilic Focus | 3 3 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | |
Necrosis, Focal | 1 3 |
Thrombosis | |
Bile Duct, Hyperplasia | 3 2 2 3 3 2 1 2 3 2 2 1 3 3 2 3 3 1 2 2|
Centrilobular, Necrosis | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 3 1 2 |
Kupffer Cell, Pigmentation | 3 2 2 4 2 2 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Accessory Spleen | |
Fat, Necrosis | 4 3 2 3 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 2 2 2 3 1 |
Acinus, Cytoplasmic Alteration | |
Acinus, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | |
Hyperplasia | 2 |
Inflammation, Subacute | |
Ulcer | 3 4 4 2 3 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|
DAY ON TEST | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|
| 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Erosion | 3 2 3 4 |
Ulcer | 3 3 |
__________________________________________________________________________|
Tongue | +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 1 2 1 2 1 2 3 3 2 2 |
Thrombosis | 3 4 4 4 3 |
Schwann Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 3 2 3 |
Degeneration, Fatty | 3 2 3 |
Hemorrhage | |
Hyperplasia, Focal | |
Hypertrophy, Focal | 1 2 |
Necrosis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 2 2 1 2 1 2 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | 3 3 3 3 3 3 3|
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Intermedia, Cyst | 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 3 3 3 |
C-Cell, Hyperplasia | 3 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3 3 3 3 3 3 3 3 3 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|
DAY ON TEST | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|
| 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia | 2 |
Inflammation, Chronic | 2 2 2 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 3 4 1 1 1 3 2 1 |
Epithelium, Hyperplasia | 1 1 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Cellular | 3 |
Myelofibrosis | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Mediastinal, Pigmentation | 3 3 3 3 3 |
Pancreatic, Pigmentation | 3 3 |
Renal, Pigmentation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + I + + + + + + + + + + + + + + + + + +|
Ectasia | 2 3|
Hemorrhage | |
Hyperplasia, Lymphoid | 4 2 3 |
Pigmentation | 2 2 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + M + +|
Ectasia | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Fibrosis | 4 2 2 3 2 2 3 3 2 2 2 |
Hematopoietic Cell Proliferation | 2 1 2 |
Necrosis | |
Pigmentation, Hemosiderin | 3 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + I + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Dilatation | 1 2 2 2 3 2 2 2 2 2 |
Hyperplasia | 3 2 1 2 3 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|
DAY ON TEST | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|
| 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | 2 |
Inflammation, Chronic | |
Epidermis, Hyperplasia | 2 |
Subcutaneous Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Femur, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 3 |
Hydrocephalus | |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 1 4 1 1 3 1 |
Alveolar Epithelium, Hyperplasia | 2 4 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Suppurative | 2 2 2 |
Goblet Cell, Hyperplasia | 1 |
Mucosa, Hyperplasia | 2 |
Mucosa, Metaplasia, Squamous | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Inflammation, Chronic | 4 |
Retina, Degeneration | |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
_____________________________________________________________________________________________________________________
| 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|
DAY ON TEST | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|
| 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
0.0% | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Mineralization | 1 1 1 1 1 2 |
Nephropathy | 1 3 1 2 2 2 1 3 3 2 2 3 2 1 1 3 2 1 1 2 1 1|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 |
Renal Tubule, Atrophy | 4|
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 2 3 2 1 2 2 2 3 |
Transitional Epithelium, Hyperplasia | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 56
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 7| 6| 8| 8| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3| | |
| 7| 0| 8| 1| 2| 3| 2| 0| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + M + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 60 |
Parasite Metazoan | X | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
Parasite Metazoan | | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 60 |
Edema | 2 | 2 2.0|
Parasite Metazoan | | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 59 |
Diverticulum | | 1 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 5 2.4|
Basophilic Focus | 2 | 7 1.6|
Clear Cell Focus | 3 | 1 3.0|
Congestion | | 1 3.0|
Degeneration, Cystic | | 9 2.1|
Eosinophilic Focus | 3 | 6 2.5|
Hemorrhage | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 4 |
Necrosis, Focal | 3 | 6 2.3|
Thrombosis | | 1 3.0|
Bile Duct, Hyperplasia | 3 2 1 2 3 1 | 47 2.4|
Centrilobular, Necrosis | | 3 2.3|
Hepatocyte, Vacuolization Cytoplasmic| 1 | 9 2.4|
Kupffer Cell, Pigmentation | 3 2 | 15 2.5|
__________________________________________________________________________|____________|
Mesentery | + + | 15 |
Accessory Spleen | | 2 |
Fat, Necrosis | 3 4 | 12 2.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Atrophy | 1 | 19 2.2|
Acinus, Cytoplasmic Alteration | 3 | 1 3.0|
Acinus, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Edema | 2 | 2 2.5|
Erosion | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 7| 6| 8| 8| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3| | |
| 7| 0| 8| 1| 2| 3| 2| 0| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 1 1 | 7 1.7|
Inflammation, Subacute | 1 | 2 1.5|
Ulcer | 3 3 | 10 3.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Edema | 2 | 2 2.0|
Erosion | 3 | 11 2.3|
Ulcer | 3 | 5 2.8|
__________________________________________________________________________|____________|
Tongue | | 2 |
Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 3 2 2 2 3 3 3 | 38 2.2|
Thrombosis | 1 | 9 3.3|
Schwann Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | 3 1 | 14 2.1|
Degeneration, Fatty | 2 1 2 2 | 7 2.1|
Hemorrhage | 3 | 3 3.0|
Hyperplasia, Focal | | 1 2.0|
Hypertrophy, Focal | | 5 1.8|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 60 |
Hyperplasia | 1 2 1 3 1 3 | 30 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia | | 3 2.3|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M M + + | 57 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Pars Distalis, Angiectasis | | 2 2.5|
Pars Distalis, Cyst | 3 | 9 3.0|
Pars Distalis, Hyperplasia, Focal | 1 3 2 | 10 1.8|
Pars Intermedia, Cyst | 3 | 8 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Ultimobranchial Cyst | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 7| 6| 8| 8| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3| | |
| 7| 0| 8| 1| 2| 3| 2| 0| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
C-Cell, Hyperplasia | 3 | 6 2.0|
Follicle, Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Atypia Cellular | 3 3 3 3 3 3 3 | 29 3.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 60 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | 2 | 12 1.8|
Inflammation, Suppurative | | 1 1.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic | | 2 2.0|
Inflammation, Suppurative | 2 2 3 2 2 2 2 | 28 2.0|
Epithelium, Hyperplasia | 1 3 | 12 1.8|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Interstitial Cell, Hyperplasia | 1 | 3 1.7|
Seminiferous Tubule, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Depletion Cellular | | 1 3.0|
Myelofibrosis | | 2 2.5|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 33 |
Mediastinal, Hemorrhage | | 3 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 2 2.0|
Mediastinal, Pigmentation | 3 3 3 | 14 2.9|
Pancreatic, Pigmentation | 3 | 4 3.0|
Renal, Pigmentation | 4 3 | 5 3.6|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Ectasia | 2 | 8 2.3|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 3 2 | 11 2.5|
Pigmentation | | 8 2.1|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 58 |
Ectasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 7| 6| 8| 8| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3| | |
| 7| 0| 8| 1| 2| 3| 2| 0| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 3 2.7|
Hyperplasia, Lymphoid | | 2 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Angiectasis | | 1 4.0|
Fibrosis | 3 2 | 19 2.7|
Hematopoietic Cell Proliferation | 2 | 6 2.0|
Necrosis | | 3 2.7|
Pigmentation, Hemosiderin | 3 1 | 11 2.5|
__________________________________________________________________________|____________|
Thymus | + + + M + + M M + + | 55 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Dilatation | 1 1 2 2 2 1 | 27 1.8|
Hyperplasia | 3 3 | 12 2.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Hyperkeratosis | | 1 2.0|
Inflammation, Chronic | 4 | 1 4.0|
Epidermis, Hyperplasia | | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Fibrous Osteodystrophy | | 1 2.0|
Femur, Osteopetrosis | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Angiectasis | | 1 3.0|
Atrophy | 3 3 | 6 3.0|
Hydrocephalus | 2 | 3 2.3|
Necrosis | | 2 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Edema | | 1 2.0|
Hemorrhage | 2 1 | 2 1.5|
Infiltration Cellular, Histiocyte | 1 3 | 17 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05217-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC T-BUTYLHYDROQUINONE Date: 03/30/95
Route: DOSED FEED Time: 20:44:01
__________________________________________________________________________________________________________________________________
| 8| 8| 6| 8| 7| 6| 8| 8| 6| 7| | |
DAY ON TEST | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3| | |
| 7| 0| 8| 1| 2| 3| 2| 0| 5| 0| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.0% | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar Epithelium, Hyperplasia | 2 3 | 6 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 5 |
Inflammation, Suppurative | 1 | 10 2.1|
Goblet Cell, Hyperplasia | | 4 1.0|
Mucosa, Hyperplasia | 2 1 | 8 2.0|
Mucosa, Metaplasia, Squamous | 1 | 4 1.8|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | 3 | 2 3.0|
Inflammation, Chronic | | 1 4.0|
Retina, Degeneration | 3 | 2 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 3.0|
Mineralization | | 11 1.2|
Nephropathy | 3 3 1 3 1 1 3 2 2 1 | 56 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 | 3 2.0|
Renal Tubule, Atrophy | | 1 4.0|
Renal Tubule, Necrosis | | 1 3.0|
Renal Tubule, Pigmentation | 2 3 2 | 23 2.1|
Transitional Epithelium, Hyperplasia | 2 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Hemorrhage | 3 | 1 3.0|
Inflammation, Suppurative | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------