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TDMS Study 05217-03 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                        T-BUTYLHYDROQUINONE


NTP Experiment-Test: 05217-03                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 03/30/95
Route: DOSED FEED                                                                                                 Time: 20:44:01


                                                 RTD FEED CORE STUDY COMPARISON


       Facility:  Southern Research Institute

       Chemical CAS #:  1948-33-0

       Lock Date:  05/26/93

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 007    0.5%
                               Include 008    0.5%
                               Include 009    0.0%
                               Include 010    0.0%





























                                                             Page   1
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|             
                             DAY ON TEST   | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|             
                                           | 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                3                                                         |             
      Parasite Metazoan                    |                      X                          X                 X      |             
      Ulcer                                |                3                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X                                X                       X  X     X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                            2                                             |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |             3  1  2           2  1  1  3  1     3        1  2  1  2     2|             
      Clear Cell Focus                     |                                                          1              2|             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                            3  4     4     3                    3  2     2|             
      Eosinophilic Focus, Multiple         |                                        3                                 |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | X     X              X  X                 X        X  X  X        X     X|             
      Inflammation, Granulomatous          |                                  1        1        1        1  2        2|             
      Mixed Cell Focus                     |                   2                 3                       2            |             
      Necrosis, Focal                      |       1                                         2     1                  |             
      Bile Duct, Cyst                      |                                     4                                    |             
      Bile Duct, Hyperplasia               | 1  2  3           3  1  3        1     1  1                       2      |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|    3                                                                     |             
      Kupffer Cell, Pigmentation           |    2     2        3     2                             1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +                                                     +  +   |             
      Accessory Spleen                     |       X                                                              X   |             
      Fat, Necrosis                        |       2     4                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              | 3        3        1                             2        1               |             
      Acinus, Cytoplasmic Alteration       |                                              4                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                             2            |             
      Hyperplasia                          |                                        4                                 |             
      Ulcer                                |                            4                                             |             
      Mucosa, Hyperplasia                  |                            3                 2              3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|             
                             DAY ON TEST   | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|             
                                           | 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                 +                        |             
      Epithelium, Hyperplasia              |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1           2  3  1     3  2  1  2  2     2  2     1     2           2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  2     1  3     2  2                     |             
      Degeneration, Fatty                  | 3                 2     1  4           3  3           3           2      |             
      Hemorrhage                           |                            3                                             |             
      Hyperplasia, Diffuse                 |                            3                                             |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |    3              2     2                                3     2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  1                                   3                          1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              3                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                        4        2                        |             
      Pars Distalis, Cyst                  | 3           3     3     3                 3     3                    3   |             
      Pars Distalis, Hyperplasia, Focal    |                                     3        1  2           2            |             
      Pars Intermedia, Cyst                | 3                                      3                 3               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                2                          2                              |             
      Follicle, Cyst                       |                                           3                              |             
      Follicular Cell, Hyperplasia         |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  3                                       |             
      Hyperplasia                          |    2                    2                                                |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3  3  3  3              3                    3           3  3        3   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|             
                             DAY ON TEST   | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|             
                                           | 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hydrometra                           |                      3                       2     2                     |             
      Hyperplasia, Cystic                  |       2                                                  1               |             
                                            __________________________________________________________________________|             
   Vagina                                  |    M  M                                                           M  +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +           +  +                          +        +     +      |             
      Mediastinal, Pigmentation            |    3                                                                     |             
      Pancreatic, Pigmentation             |          3              3                                         3      |             
      Renal, Hemorrhage                    |                                                    2        2            |             
      Renal, Pigmentation                  | 3  3  3                                            4        3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                2              2  2        2     2           2            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Pigmentation                         |             2        2           2  2     2        2                 2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      3                                                   |             
      Hemorrhage                           |                            3  2              2                       3   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2           2                                                      |             
      Hematopoietic Cell Proliferation     |             2                                2              1     3      |             
      Hemorrhage                           |                      3                                                   |             
      Hyperplasia, Lymphoid                |                                                          3               |             
      Metaplasia, Lipocyte                 |                                                          2               |             
      Necrosis                             |       2                                                                  |             
      Pigmentation, Hemosiderin            |             3  3           3  3  2  2  2  3  2  3  3     2  2  2     2  3|             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2           2  2        2     3  2  2  2  3        3           1  2  2  2|             
      Galactocele                          |                            4                                             |             
      Hyperplasia                          |    3  3           3  1                       3        3  2               |             
      Inflammation, Suppurative            |                                              4                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                  2                                       |             
      Epidermis, Hyperplasia               |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|             
                             DAY ON TEST   | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|             
                                           | 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                              4                           |             
      Hyperostosis                         |                                                                          |             
      Cranium, Osteopetrosis               |                         3     3                                   3      |             
      Femur, Osteopetrosis                 |                         3     3                             2            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2  3           2                       3           3  2     4|             
      Hemorrhage                           |                               3                                          |             
      Hydrocephalus                        |                2                                                        3|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                           +                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        1                          1      |             
      Infiltration Cellular, Histiocyte    | 3  2  1  1  2  1        2  2  1  1  1     1              1               |             
      Alveolar Epithelium, Hyperplasia     |          2                             1                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                               1        2                                 |             
      Goblet Cell, Hyperplasia             |             1                 1        1                          1      |             
      Mucosa, Hyperplasia                  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
      Cataract                             |                   4                                                      |             
      Retina, Degeneration                 |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              3  3                        |             
      Inflammation, Chronic                |                                                          2               |             
      Mineralization                       | 1        2  1  2  1  2  2  2        2  1  1     2  2  1  2  1  2     2  2|             
      Nephropathy                          |          1  1  2  1        4  1  2  2  1  1  4  2  3     3     1  1     2|             
      Renal Tubule, Atrophy                |                                     2                                1   |             
      Renal Tubule, Cytoplasmic Alteration |                2                                                         |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Necrosis               |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 8| 8| 6| 8| 6| 7| 6| 8| 8| 8| 8| 8| 8| 8| 8| 6| 8| 6| 7| 8| 8| 6|             
                             DAY ON TEST   | 7| 8| 1| 1| 5| 3| 8| 1| 5| 4| 6| 9| 9| 9| 7| 0| 9| 9| 7| 9| 2| 5| 9| 4| 6|             
                                           | 3| 9| 2| 0| 6| 3| 8| 3| 0| 0| 9| 8| 8| 8| 9| 7| 4| 8| 3| 8| 8| 2| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Pigmentation           | 3  3  2  2                                                        2     1|             
      Transitional Epithelium, Hyperplasia |    2                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|             
                             DAY ON TEST   | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|             
                                           | 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |       X                                                                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X              X        X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 3                                                                        |             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Basophilic Focus                     |    3     2        2  1  1              3              2  1  1        2  2|             
      Clear Cell Focus                     |                                     4                                    |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |          3        2  3  3              3     3     3                    3|             
      Eosinophilic Focus, Multiple         |                                                                          |             
      Hematopoietic Cell Proliferation     |                1                                                        1|             
      Hepatodiaphragmatic Nodule           | X     X           X           X  X     X                                 |             
      Inflammation, Granulomatous          |                   1                                1                     |             
      Mixed Cell Focus                     |                   1        2                             1               |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2           3        1     2     1     3           1  1        1         |             
      Centrilobular, Necrosis              |                1                                                         |             
      Hepatocyte, Vacuolization Cytoplasmic| 4                                                                        |             
      Kupffer Cell, Pigmentation           |                            2                                2     1      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +                                            +         |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        | 1                 3                                            3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      2                 1  1                 1        2   |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Ulcer                                | 3                                                                        |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|             
                             DAY ON TEST   | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|             
                                           | 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    3        2        2                 2  1  1  1     2     2  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         2                                               2|             
      Degeneration, Fatty                  |          3                                                               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |                                                    1                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                    1                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  M  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    3                    2                 3                              |             
      Pars Distalis, Cyst                  | 3           3  3           3                 3                           |             
      Pars Distalis, Hyperplasia, Focal    |             3           1                                                |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                  3                                       |             
      C-Cell, Hyperplasia                  |             2                                      1  1     2           4|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   3                 3              3                 3   |             
      Hyperplasia                          |                                                       3                  |             
      Inflammation, Chronic                |                                                    3                     |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3              3     3                          3         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|             
                             DAY ON TEST   | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|             
                                           | 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hydrometra                           | 3           2              2                 2                           |             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                            M                       M        M            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Myelofibrosis                        |                                              1                    3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +                       +  +  +              +            |             
      Mediastinal, Pigmentation            |                3                       3  3  3                           |             
      Pancreatic, Pigmentation             |          4                                                               |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Pigmentation                  |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                                                   |             
      Hyperplasia, Lymphoid                |                                                                         2|             
      Hyperplasia, Plasma Cell             |                                                          2               |             
      Pigmentation                         | 2     2        3     2     2  2  2  2           2  3  2  2           2  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                         2|             
      Hemorrhage                           | 2                       2                                                |             
      Hyperplasia, Lymphoid                |                2     3                                2                  |             
      Pigmentation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 1              3  2              2                                      3|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Metaplasia, Lipocyte                 |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            | 3  2  3  3     3  2  2  2  2     2              2  3  3  2     3  1  2  2|             
      Red Pulp, Atrophy                    |                                                          3               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          3           2     2     1  2  1  2  2  3  1  2  2  2  2     2   |             
      Galactocele                          |                   3        3                                            3|             
      Hyperplasia                          | 3  2  1     2           1     3                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                        X                                 |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|             
                             DAY ON TEST   | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|             
                                           | 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                                                          |             
      Cranium, Osteopetrosis               |             3              2  3                                          |             
      Femur, Osteopetrosis                 |                                        2  3                              |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3           4  3        4     4  2        3  2  3  4     3     2  4|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                   2                 2              2  3              2  2|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                +        +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1              1           1  1     1  1  1                    1     1  1|             
      Alveolar Epithelium, Hyperplasia     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Goblet Cell, Hyperplasia             |                                                                   2      |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |    2                 2                                               2   |             
      Mineralization                       | 3  1  1  1  1  1     2  1  1  1  1  2  2  2  2     2  2  1  2     2  2  2|             
      Nephropathy                          |    1  1  1        2  2  1     1     2  1        1     2     1        3  2|             
      Renal Tubule, Atrophy                |    2                 3                                                   |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Dilatation             |                2                                                         |             
      Renal Tubule, Necrosis               |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 8| 5| 8| 7| 6| 8| 8| 8| 8| 6| 5| 8| 8| 7| 8| 7| 8| 8| 7| 8| 6| 5| 8| 8|             
                             DAY ON TEST   | 9| 9| 7| 5| 8| 2| 6| 9| 9| 9| 9| 9| 4| 9| 0| 3| 7| 3| 9| 8| 9| 5| 0| 9| 9|             
                                           | 6| 8| 2| 8| 9| 8| 2| 8| 8| 8| 0| 1| 1| 7| 5| 1| 7| 0| 8| 9| 1| 9| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.5%                                   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Pigmentation           |    2        1        2              2  2  2           2                 2|             
      Transitional Epithelium, Hyperplasia |                                              1           1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                            1           1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 6| 8| 8|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9|                                            |            |
                                           | 8| 8| 8| 8| 4| 1| 0| 1| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      1  3.0|
      Parasite Metazoan                    |                            X                                             |      5     |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  I  +                                             |  59        |
      Parasite Metazoan                    |                                                                          |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      2  2.5|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | 2  2  2                    2                                             |     29  1.8|
      Clear Cell Focus                     |    1                 1                                                   |      5  1.8|
      Degeneration, Cystic                 |                1                                                         |      1  1.0|
      Eosinophilic Focus                   | 3  3                                                                     |     17  2.9|
      Eosinophilic Focus, Multiple         |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hepatodiaphragmatic Nodule           |          X              X                                                |     18     |
      Inflammation, Granulomatous          |          1           1                                                   |     10  1.2|
      Mixed Cell Focus                     | 3                                                                        |      7  2.0|
      Necrosis, Focal                      |                                                                          |      3  1.3|
      Bile Duct, Cyst                      |                                                                          |      1  4.0|
      Bile Duct, Hyperplasia               | 1     1        2        1  1                                             |     24  1.6|
      Centrilobular, Necrosis              |                                                                          |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|                         3                                                |      3  3.3|
      Kupffer Cell, Pigmentation           |                         2                                                |      9  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Accessory Spleen                     |                                                                          |      2     |
      Fat, Necrosis                        |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |    3  2  4                                                               |     13  2.0|
      Acinus, Cytoplasmic Alteration       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 6| 8| 8|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9|                                            |            |
                                           | 8| 8| 8| 8| 4| 1| 0| 1| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      2  3.5|
      Mucosa, Hyperplasia                  |          1              3                                                |      5  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |             2              2                                             |     28  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    | 2                    1                                                   |      9  1.9|
      Degeneration, Fatty                  | 3        2           1                                                   |     12  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Diffuse                 |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                         1  4                                             |      2  2.5|
      Hypertrophy, Focal                   |                                                                          |      7  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                1                                                         |      7  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |             4        4                                                   |      7  3.1|
      Pars Distalis, Cyst                  | 3  3     3     3  3  3     3                                             |     19  3.0|
      Pars Distalis, Hyperplasia, Focal    | 3  1                 3                                                   |      9  2.1|
      Pars Intermedia, Cyst                |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  |    1                                                                     |      8  1.9|
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 6| 8| 8|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9|                                            |            |
                                           | 8| 8| 8| 8| 4| 1| 0| 1| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      5  3.0|
      Hyperplasia                          |                         2                                                |      4  2.3|
      Inflammation, Chronic                |                         2                                                |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |          3           3  3  3                                             |     17  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                                                                          |      7  2.3|
      Hyperplasia, Cystic                  |                         1                                                |      3  1.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                            2                                             |      1  2.0|
      Myelofibrosis                        |                         3                                                |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +  +                                                         |  18        |
      Mediastinal, Pigmentation            |             3                                                            |      6  3.0|
      Pancreatic, Pigmentation             |                                                                          |      4  3.3|
      Renal, Hemorrhage                    |                                                                          |      2  2.0|
      Renal, Pigmentation                  |                3                                                         |      7  3.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      7  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Pigmentation                         |    2  2     2     2                                                      |     25  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      2  2.5|
      Hemorrhage                           |             2                                                            |      7  2.3|
      Hyperplasia, Lymphoid                |          2                                                               |      4  2.3|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                            2                                             |      3  2.0|
      Hematopoietic Cell Proliferation     |                   2  1                                                   |     11  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Metaplasia, Lipocyte                 |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            | 3  2  2     2     2  2     3                                             |     41  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 6| 8| 8|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9|                                            |            |
                                           | 8| 8| 8| 8| 4| 1| 0| 1| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           | 2     2     2     2     2                                                |     34  2.0|
      Galactocele                          |                4                                                         |      5  3.4|
      Hyperplasia                          |                      2     2                                             |     15  2.3|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Ulcer                                |                            1                                             |      2  1.5|
      Epidermis, Hyperplasia               |                            2                                             |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |                                                                          |      1  4.0|
      Hyperostosis                         |                         3                                                |      1  3.0|
      Cranium, Osteopetrosis               | 2              2           2                                             |      9  2.6|
      Femur, Osteopetrosis                 |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                3        3                                                |     22  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      8  2.3|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                         +                                                |   4        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      2  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |     23  1.3|
      Alveolar Epithelium, Hyperplasia     |          1                                                               |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |          2                                                               |      3  1.7|
      Goblet Cell, Hyperplasia             |                      1                                                   |      6  1.2|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 6| 8| 8|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 7| 3| 0| 9| 3| 9|                                            |            |
                                           | 8| 8| 8| 8| 4| 1| 0| 1| 9| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      2  3.0|
      Inflammation, Chronic                |    2                                                                     |      5  2.0|
      Mineralization                       | 2  2     1     2  2  2  2                                                |     48  1.6|
      Nephropathy                          | 2  3  2  2     2  1     2  3                                             |     39  1.8|
      Renal Tubule, Atrophy                |    1                                                                     |      5  1.8|
      Renal Tubule, Cytoplasmic Alteration |                3                                                         |      2  2.5|
      Renal Tubule, Dilatation             |                                                                          |      1  2.0|
      Renal Tubule, Necrosis               |                                                                          |      2  3.5|
      Renal Tubule, Pigmentation           |                3        2                                                |     16  2.1|
      Transitional Epithelium, Hyperplasia |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Transitional Epithelium, Hyperplasia |                                                                          |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|             
                             DAY ON TEST   | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|             
                                           | 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    3                     |             
      Basophilic Focus                     | 3           2        3     2     3  2     4        4     2     3  3  1  3|             
      Clear Cell Focus                     |                            3                             2               |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                    3     3        3     3|             
      Hematopoietic Cell Proliferation     |                            2                                             |             
      Hepatodiaphragmatic Nodule           |                         X              X              X           X  X   |             
      Inflammation, Granulomatous          |                                                          1              3|             
      Mixed Cell Focus                     |                                                                         4|             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               |                1        2     3                                   1  1   |             
      Centrilobular, Atrophy               |                               2                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                3                                                         |             
      Kupffer Cell, Pigmentation           |                2        2     2                       3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +  +           +                                          |             
      Accessory Spleen                     |       X        X                                                         |             
      Fat, Necrosis                        |                3  2                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   2     2        2  1        1              1  2         |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Ulcer                                |                   2                    1                                 |             
      Mucosa, Hyperplasia                  |                3     3                 2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                3                                                         |             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|             
                             DAY ON TEST   | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|             
                                           | 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                2                       3                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3        2     1  2  2  1  2        3  3  2  1     3     2     2  3  2   |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             1                                         1           1      |             
      Degeneration, Fatty                  |                4     3                    3                              |             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Focal                   |                                     2                             3      |             
      Hypertrophy, Focal                   | 3           1                             2                              |             
      Necrosis                             |                                        3                                 |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                            1  3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3                 2                                   1     2            |             
      Pars Distalis, Atypia Cellular       |                                                                          |             
      Pars Distalis, Cyst                  |             3     3        3     3                                      3|             
      Pars Distalis, Hyperplasia, Focal    | 2                          2     3                          1            |             
      Pars Intermedia, Angiectasis         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |          3                                                               |             
      C-Cell, Hyperplasia                  |                                  3                 1                     |             
      Follicular Cell, Hyperplasia         |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |    3              3     3                                                |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                         2                                         2      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|             
                             DAY ON TEST   | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|             
                                           | 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                3  3                                         3     3      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                   2                                                  2   |             
      Hyperplasia, Cystic                  |                   2                 1                                    |             
                                            __________________________________________________________________________|             
   Vagina                                  |    M           M  M  M                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Stromal Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +           +     +     +              +              +     +      |             
      Iliac, Hemorrhage                    |                                              1                           |             
      Iliac, Hyperplasia, Lymphoid         |                                              3                           |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Pigmentation            |                               3                                   2      |             
      Pancreatic, Pigmentation             |                                                                          |             
      Renal, Pigmentation                  |                                                                   4      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              2                           |             
      Hemorrhage                           |                                                                      1   |             
      Hyperplasia, Lymphoid                |                            2              2  2     2           2        3|             
      Pigmentation                         | 2        2                 2     2     2  2  2     2              2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2        2                             2                     |             
      Hyperplasia, Lymphoid                |                            3                                             |             
      Pigmentation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2     2                                          |             
      Hematopoietic Cell Proliferation     |          2                 3     1           3           1               |             
      Pigmentation, Hemosiderin            | 2        3  2        3           2           3     2     2     3     2   |             
      Red Pulp, Atrophy                    |                                                 4                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 1  1        1  3        2        3  4     2        1  2     1  3  2  2  3|             
      Galactocele                          |                                                                      3   |             
      Hyperplasia                          |                   3  3     2           2     1                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperkeratosis                       | 2                                                                        |             
      Inflammation, Chronic                |                                                                   2      |             
      Ulcer                                |                                                                          |             
      Epidermis, Hyperplasia               | 2                                                                 3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|             
                             DAY ON TEST   | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|             
                                           | 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               | 2                             3  3     2                          3     3|             
      Femur, Osteopetrosis                 |                3        3        3  2     2                       3     3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                 3                 2           3     3           3   |             
      Gliosis                              |          3                                                               |             
      Hydrocephalus                        |                      3                                                   |             
      Necrosis                             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        2                          2      |             
      Hemorrhage                           |                                                                3         |             
      Infiltration Cellular, Histiocyte    | 1  1           1                 1     2     1     2  2  1  1     2  1   |             
      Inflammation, Subacute               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              2        2                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                         X|             
      Inflammation, Suppurative            |                                                                2        2|             
      Goblet Cell, Hyperplasia             |                                  1           1                 1        1|             
      Mucosa, Hyperplasia                  |                                                                         2|             
      Mucosa, Metaplasia, Squamous         |                                                                1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                              3                           |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 2     2  2  2     2  1  1  2  1  1  2  2     2  3  1  1  1  2  2  2  2  1|             
      Nephropathy                          | 2           1        2  2     1  1  2        1     2     2              1|             
      Renal Tubule, Atrophy                |                3                                                         |             
      Renal Tubule, Cytoplasmic Alteration |          3                                         2                     |             
      Renal Tubule, Necrosis               |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 5| 6| 8| 7| 8| 8| 8| 7| 8| 8| 8| 6| 8| 6| 3| 8| 7| 8| 7| 8| 8| 8| 8|             
                             DAY ON TEST   | 9| 6| 0| 4| 9| 7| 3| 2| 9| 3| 1| 9| 9| 0| 9| 3| 5| 5| 0| 5| 5| 6| 8| 0| 9|             
                                           | 8| 3| 9| 8| 9| 5| 1| 5| 0| 3| 0| 8| 9| 1| 8| 3| 1| 9| 8| 9| 6| 5| 5| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Pigmentation           |                               2        2     2                           |             
      Transitional Epithelium, Hyperplasia |                                              1                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|             
                             DAY ON TEST   | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|             
                                           | 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                         2|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | 3  1  1     4  2  2     2  3        2     3  3                 3  4  1   |             
      Clear Cell Focus                     |                                                                   1  2   |             
      Degeneration, Cystic                 |             3                                                            |             
      Eosinophilic Focus                   | 3                 3        3              3                    3  3      |             
      Hematopoietic Cell Proliferation     |                                           1        1                     |             
      Hepatodiaphragmatic Nodule           |                X           X  X           X              X        X  X   |             
      Inflammation, Granulomatous          | 1                                      1                    1            |             
      Mixed Cell Focus                     |                            3                                             |             
      Necrosis, Focal                      |             3                                1                           |             
      Bile Duct, Hyperplasia               |          3  2        3  1  1     2              2     1  2  1           2|             
      Centrilobular, Atrophy               |                                                                          |             
      Centrilobular, Necrosis              |                               3                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                               3  3              4     3  3              3|             
      Kupffer Cell, Pigmentation           |                               3  3              3     2                 3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Accessory Spleen                     |                                                                         X|             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2              2  2        2     1  2  1  1                       2|             
      Acinus, Cytoplasmic Alteration       |                                                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          4               |             
      Inflammation, Chronic                |                                                             4            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     2                                    |             
      Erosion                              |                               3                    2                     |             
      Ulcer                                |                                                             4            |             
      Mucosa, Hyperplasia                  |                                                    1  3  4  3        1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|             
                             DAY ON TEST   | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|             
                                           | 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                               3                          3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                        2                                 |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  1     1           1  1           3  2  1     3  2        2     1  2|             
      Thrombosis                           |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          3     3                 1  1                                    |             
      Degeneration, Fatty                  |                      2           2              1                        |             
      Fibrosis                             |                   2                                                      |             
      Hyperplasia, Focal                   | 2                    2           1                                       |             
      Hypertrophy, Focal                   |                3                                                        2|             
      Necrosis                             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                       2                                         1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2                                                                       3|             
      Pars Distalis, Atypia Cellular       |                2                                                         |             
      Pars Distalis, Cyst                  | 3                                      3        3                       3|             
      Pars Distalis, Hyperplasia, Focal    | 2                          3                                             |             
      Pars Intermedia, Angiectasis         |                               2                          3               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                     3                                    |             
      C-Cell, Hyperplasia                  |                      3  3           1  1                          1      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           3     3                        |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                       3                  |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|             
                             DAY ON TEST   | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|             
                                           | 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |    3                    3           3                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                         2  3              2                              |             
      Hyperplasia, Cystic                  | 1                                                                        |             
                                            __________________________________________________________________________|             
   Vagina                                  |                         M     M  M                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    3                     |             
      Myelofibrosis                        |                                                       4                  |             
      Stromal Cell, Hyperplasia            |                                           4                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +     +                    +                          +              +|             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Mediastinal, Hemorrhage              |    3                                                                     |             
      Mediastinal, Pigmentation            |                                                                         3|             
      Pancreatic, Pigmentation             |          3                                                              3|             
      Renal, Pigmentation                  |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                     2                                    |             
      Hemorrhage                           |                                           2                          1   |             
      Hyperplasia, Lymphoid                |       2                             2     2        2              2      |             
      Pigmentation                         |             2  2     2  2           2     2  2     2  2     2  2     3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |    2                                                              2      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    3                 3                                                   |             
      Hematopoietic Cell Proliferation     |    2                                      3        3        3  2         |             
      Pigmentation, Hemosiderin            |       2           3  2  3     2     3           3        3     2  2  3   |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       3  4  3  2     2  2     3  3  2  2  3        2     2               |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                                                       3        3     2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                             4            |             
      Ulcer                                |                                           2                 4            |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|             
                             DAY ON TEST   | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|             
                                           | 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |    2        4        2              3  2           3           3        2|             
      Femur, Osteopetrosis                 |             4                       3  2  2        3           4        3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3  3           4  4        2  3     2                    4     4  3|             
      Gliosis                              |                                                                          |             
      Hydrocephalus                        |                      3  2                                                |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    2  2  2     1  3  1        1     1  2  1     1           4  1  2  1   |             
      Inflammation, Subacute               |                                                             4            |             
      Alveolar Epithelium, Hyperplasia     |          1                 1  2                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Goblet Cell, Hyperplasia             |                1  1                                                      |             
      Mucosa, Hyperplasia                  |                                                                          |             
      Mucosa, Metaplasia, Squamous         |                                           1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                4         |             
      Inflammation, Suppurative            |                                                          2               |             
      Mineralization                       | 3  2  1     1  2  1  2  1  1  1  2  2  2     2  2     3  2  2  2  2  2  2|             
      Nephropathy                          |    1  3  1  1  2  2  3  2           2  2  1  2     2  1  1     3  1  1  1|             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 8| 8| 8| 8| 7| 8| 7| 8| 7| 8| 8| 8| 7| 8| 8| 8| 4| 8| 8| 7| 8|             
                             DAY ON TEST   | 5| 4| 9| 4| 9| 9| 9| 9| 8| 1| 7| 1| 1| 9| 9| 9| 3| 4| 9| 6| 0| 9| 9| 2| 3|             
                                           | 8| 8| 8| 4| 9| 8| 9| 8| 8| 7| 7| 7| 7| 9| 8| 9| 8| 9| 8| 1| 8| 9| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0%                                   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Pigmentation           |          2              2        2  2                                   2|             
      Transitional Epithelium, Hyperplasia |                               2                          3     2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 8| 8| 6| 7| 8| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2|                                            |            |
                                           | 8| 0| 0| 9| 9| 9| 8| 8| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Subacute               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    | X                                                                        |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                         1                                                |      2  2.0|
      Basophilic Focus                     | 3     2  3  3  2     2  2                                                |     34  2.5|
      Clear Cell Focus                     |                                                                          |      4  2.0|
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Eosinophilic Focus                   |          3  2                                                            |     12  2.9|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.3|
      Hepatodiaphragmatic Nodule           |                                                                          |     12     |
      Inflammation, Granulomatous          |       1  2  2           3                                                |      9  1.7|
      Mixed Cell Focus                     |       3                                                                  |      3  3.3|
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |    3           1                                                         |     18  1.8|
      Centrilobular, Atrophy               |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      7  3.1|
      Kupffer Cell, Pigmentation           |                                                                          |      9  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Accessory Spleen                     |                                                                          |      3     |
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              | 2        1        1     3                                                |     20  1.7|
      Acinus, Cytoplasmic Alteration       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                   3                                                      |      2  2.5|
      Erosion                              |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 8| 8| 6| 7| 8| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2|                                            |            |
                                           | 8| 0| 0| 9| 9| 9| 8| 8| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                   3                                                      |      4  2.5|
      Mucosa, Hyperplasia                  |                         2                                                |      9  2.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  3.0|
      Erosion                              |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Subacute               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2        2  2  3  1     2                                                |     35  1.9|
      Thrombosis                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                   1                                                      |      8  1.5|
      Degeneration, Fatty                  | 1                 1                                                      |      8  2.1|
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                1                                                         |      6  1.8|
      Hypertrophy, Focal                   | 1           2           1                                                |      8  1.9|
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |    1                                                                     |      7  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Angiectasis           |             3                                                            |      7  2.3|
      Pars Distalis, Atypia Cellular       |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |          3              3                                                |     11  3.0|
      Pars Distalis, Hyperplasia, Focal    |          3                                                               |      7  2.3|
      Pars Intermedia, Angiectasis         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ultimobranchial Cyst                 |                                                                          |      2  3.0|
      C-Cell, Hyperplasia                  |                   1     3                                                |      9  1.9|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 8| 8| 6| 7| 8| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2|                                            |            |
                                           | 8| 0| 0| 9| 9| 9| 8| 8| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      5  3.0|
      Fibrosis                             |                3                                                         |      1  3.0|
      Hyperplasia                          | 2                                                                        |      4  2.3|
      Inflammation, Chronic                |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |          2                                                               |      1  2.0|
      Cyst                                 |          3        3                                                      |      9  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                                                                          |      5  2.2|
      Hyperplasia, Cystic                  |                         3                                                |      4  1.8|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      1  4.0|
      Stromal Cell, Hyperplasia            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |  14        |
      Iliac, Hemorrhage                    |                                                                          |      1  1.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Pigmentation            |                                                                          |      3  2.7|
      Pancreatic, Pigmentation             |                                                                          |      2  3.0|
      Renal, Pigmentation                  |    3                                                                     |      3  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      3  1.3|
      Hyperplasia, Lymphoid                |                            3                                             |     12  2.2|
      Pigmentation                         | 3     2        2        2  2                                             |     27  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                         1                                                |      4  1.8|
      Hyperplasia, Lymphoid                |                         2                                                |      4  2.3|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      4  2.5|
      Hematopoietic Cell Proliferation     |       2           1                                                      |     12  2.2|
      Pigmentation, Hemosiderin            | 2     2  3     3  3     2  3                                             |     28  2.5|
      Red Pulp, Atrophy                    |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 8| 8| 6| 7| 8| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2|                                            |            |
                                           | 8| 0| 0| 9| 9| 9| 8| 8| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           | 2     2        2     2     2                                             |     33  2.2|
      Galactocele                          |                                                                          |      1  3.0|
      Hyperplasia                          |    2                    1  2                                             |     12  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Ulcer                                |                                                                          |      2  3.0|
      Epidermis, Hyperplasia               |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cranium, Osteopetrosis               | 3     2  2                                                               |     17  2.6|
      Femur, Osteopetrosis                 | 3     2  2                                                               |     17  2.8|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              | 2     3        3  3  4     4                                             |     22  3.0|
      Gliosis                              |                                                                          |      1  3.0|
      Hydrocephalus                        |                      2                                                   |      4  2.5|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |       2  1  2     1  1  1                                                |     33  1.5|
      Inflammation, Subacute               |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     | 3                                                                        |      6  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      1     |
      Inflammation, Suppurative            |          1                                                               |      3  1.7|
      Goblet Cell, Hyperplasia             | 1                       1                                                |      8  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 8| 8| 6| 7| 8| 5|                                            |            |
                             DAY ON TEST   | 9| 1| 0| 9| 9| 9| 6| 3| 9| 2|                                            |            |
                                           | 8| 0| 0| 9| 9| 9| 8| 8| 8| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
      Mucosa, Metaplasia, Squamous         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       | 1        1  1  1  2  3  1  1                                             |     52  1.7|
      Nephropathy                          | 2  1     1  1  2     1  1  1                                             |     38  1.6|
      Renal Tubule, Atrophy                |                                                                          |      1  3.0|
      Renal Tubule, Cytoplasmic Alteration |                2                                                         |      3  2.3|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           | 2                                                                        |      9  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|             
                             DAY ON TEST   | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|             
                                           | 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                      X                             X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                 3  3                                    |             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                    1     4                    1              2   |             
      Basophilic Focus                     |          1              1                                                |             
      Clear Cell Focus                     |          1           1                                                   |             
      Degeneration, Cystic                 |                                  4           2                           |             
      Eosinophilic Focus                   |                      3                                2                  |             
      Hepatodiaphragmatic Nodule           |          X                          X                 X                  |             
      Mixed Cell Focus                     |                                              2                           |             
      Necrosis, Focal                      |                   2                 2                                    |             
      Thrombosis                           |             1                                                            |             
      Bile Duct, Hyperplasia               | 3     4                    1  2  3  3  3  3     3  3                 4  1|             
      Centrilobular, Fibrosis              |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                        3     2              3            |             
      Kupffer Cell, Pigmentation           |             2                       2                       2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +                    +     +  +           +  +           +     +|             
      Accessory Spleen                     |                                        X              X                 X|             
      Fat, Necrosis                        |       3  3                    2     3              3  3           3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1  2  2                          3  2  3  2     1              1  1   |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
      Acinus, Hyperplasia, Focal           |    1                                                              1      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  4                          2            |             
      Hyperplasia                          |                4                                   1        2  2         |             
      Ulcer                                |                                                             3            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|             
                             DAY ON TEST   | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|             
                                           | 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                 +                        |             
      Epithelium, Hyperplasia              |                               3                 1                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                      3                                         2  2      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1     2  1  3  2  2  2     2  2  2     3     3  3     1     3  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    1     1                    1        1     1                          1|             
      Degeneration, Fatty                  |       1                                         1                        |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |          3                                                               |             
      Hypertrophy, Focal                   |                               2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                             2     1                 3        1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nuclear Alteration                   |                                                                          |             
      Pars Distalis, Cyst                  |                   3                          3  3                        |             
      Pars Distalis, Hyperplasia, Focal    |    1        3           2  1     3  3                          3         |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |          3                 3                                             |             
      C-Cell, Hyperplasia                  |       2                          2  1                    1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      | 3                 3  3  3              3  3        3  3  3  3           3|             
      Granuloma Sperm                      |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|             
                             DAY ON TEST   | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|             
                                           | 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                      1   |             
      Inflammation, Chronic                |    2        2           2                                      2  2      |             
      Inflammation, Suppurative            |       1           4        3                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2  1        2  2     1  1              2|             
      Epithelium, Hyperplasia              |    2                    2        3                          1            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         |       3                                      3                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          3               |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Myelofibrosis                        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +     +           +  +  +  +        +  +     +  +  +     +   |             
      Inguinal, Hyperplasia, Lymphoid      |                                                          4               |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                2         |             
      Mediastinal, Pigmentation            |       3     3     3                 3  3                       2         |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
      Pancreatic, Pigmentation             |                                                 3                        |             
      Renal, Ectasia                       |                                     3                                    |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Pigmentation                  |                               3  3  4              3                 4   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 3                                      2                       2         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |          2     2        3  3                 2        3        2         |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        4  3                    3     4   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2     2        3           3  3     2     2                    2   |             
      Hematopoietic Cell Proliferation     |                                                       2  3               |             
      Pigmentation, Hemosiderin            |          3  2                                2                          1|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|             
                             DAY ON TEST   | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|             
                                           | 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Dilatation                           |                               1                 2              2     2   |             
      Galactocele                          |                                           2                 3            |             
      Hyperplasia                          |                   1                          2                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                    X                     |             
      Hemorrhage                           |                                                                          |             
      Hyperkeratosis                       |                                           3                              |             
      Epidermis, Hyperplasia               |                            2                                             |             
      Subcutaneous Tissue, Thrombosis      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                     2                                    |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |          1     1        1                    1     2                     |             
      Inflammation, Subacute               |                                                                3         |             
      Alveolar Epithelium, Hyperplasia     |                                              2  2  2           2     2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                X        X                                                |             
      Inflammation, Suppurative            |       1  3     2        2              1                                 |             
      Goblet Cell, Hyperplasia             |       1     1  2     1           1                                1  1   |             
      Mucosa, Hyperplasia                  |          3        1     2                                               1|             
      Mucosa, Metaplasia, Squamous         |          3              2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +           +                                          |             
      Atrophy                              |                   4                                                      |             
      Cataract                             |                               3                                          |             
      Retina, Degeneration                 |                               3                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 8| 8| 8| 8| 5| 8| 8| 7| 7| 8| 8| 6| 6| 8| 7| 7| 6| 5| 7| 7| 8| 7| 6|             
                             DAY ON TEST   | 0| 5| 3| 5| 5| 5| 8| 5| 5| 8| 3| 5| 0| 2| 8| 5| 4| 4| 4| 2| 6| 5| 5| 7| 0|             
                                           | 8| 7| 9| 7| 7| 7| 9| 7| 7| 6| 0| 7| 6| 6| 2| 7| 5| 5| 2| 0| 7| 0| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3                                3                                    |             
      Inflammation, Suppurative            |          2  1                    1  2     1                    1     1   |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  3  2  3  3  4  2  3  3  2  2  3  3  1  3  4  3  2  1  2  2  3  3  3  2|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Atrophy                |                               3                                          |             
      Renal Tubule, Pigmentation           |                            1  2     3  3        2  3        2        3   |             
      Transitional Epithelium, Hyperplasia |       3        1                 2  1        1                 1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|             
                             DAY ON TEST   | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|             
                                           | 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                           3                              |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                           4                              |             
      Hemorrhage                           |                                                                          |             
      Parasite Metazoan                    |          X                                      X  X  X     X        X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              | 3  3                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |    3                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Basophilic Focus                     |                                     1  1        3        2               |             
      Clear Cell Focus                     |                2                             1           1               |             
      Degeneration, Cystic                 |                                  1              1        3               |             
      Eosinophilic Focus                   |                                                 1                        |             
      Hepatodiaphragmatic Nodule           |                         X                 X                       X      |             
      Mixed Cell Focus                     |                                                          4               |             
      Necrosis, Focal                      |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 3     3              3  2     2  2                                   4   |             
      Centrilobular, Fibrosis              |                                                    3                     |             
      Centrilobular, Necrosis              |                         3                                                |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Pigmentation           |       2              2        3  1                 4           2         |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                         +  +        +     +            |             
      Accessory Spleen                     |                                                             X            |             
      Fat, Necrosis                        | 4                                         3  2        3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        1           2  1              2   |             
      Acinus, Cytoplasmic Alteration       |    4     3  3                                                            |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 3  3                    2                 2                              |             
      Hyperplasia                          | 2  3     3  3                             3     4                        |             
      Ulcer                                | 4  2     4  4                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|             
                             DAY ON TEST   | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|             
                                           | 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Edema                                | 2  2        2                                                            |             
      Erosion                              |                   3                                                      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                           +                              |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3  3  1     3  3  2     3     2     3  1     2     1        3     1      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    2                       1           1                 2  1            |             
      Degeneration, Fatty                  |    1  2                                                  1  2        2   |             
      Hemorrhage                           |                3                                   2                     |             
      Hyperplasia, Focal                   |                                                                         3|             
      Hypertrophy, Focal                   |       3                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3        3                 3                          1        3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          | 3  3     3  3           2           2                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nuclear Alteration                   |                                                                          |             
      Pars Distalis, Cyst                  |                                     3           3                        |             
      Pars Distalis, Hyperplasia, Focal    |                                     2  4        2              2         |             
      Pars Intermedia, Angiectasis         |                3                                                         |             
      Pars Intermedia, Cyst                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                      3                                                  3|             
      C-Cell, Hyperplasia                  |          3     2                                   2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Peritoneum                              |                         +                                   +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |    3     3              3     3        3     3  3  3  3  3        3  3   |             
      Granuloma Sperm                      |                                           3                              |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3                 3        3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|             
                             DAY ON TEST   | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|             
                                           | 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                    2                     |             
      Inflammation, Chronic                |                2        2              2           2                    2|             
      Inflammation, Suppurative            |                                                 2                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1              3  2     2     1           2  3  1     3     3           3|             
      Epithelium, Hyperplasia              |                2                                         1  2            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                            2  1                       1                  |             
      Seminiferous Tubule, Atrophy         |                               1                          4              3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         3  4                    2           3     3     2|             
      Infiltration Cellular, Histiocyte    |                                                             2            |             
      Myelofibrosis                        |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +        +  +  +     +  +     +  +              +  +     +  +   |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Congestion              |                                                                   3      |             
      Mediastinal, Hemorrhage              |          3                             3  3                              |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             2            |             
      Mediastinal, Pigmentation            |       3  3              4              3  3              3  4        2   |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
      Pancreatic, Pigmentation             |                      3                                                   |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hemorrhage                    | 3                                                                        |             
      Renal, Pigmentation                  | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            2                 2                           |             
      Hemorrhage                           |                               3              2                    2      |             
      Hyperplasia, Lymphoid                |                3        2  3        3        3        3     2     2      |             
      Pigmentation                         | 2                                                        2     2  3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2                    3                    3  2            |             
      Hemorrhage                           | 3                                                  3                     |             
      Hyperplasia, Lymphoid                |             3           2  2              2           3                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             | 4                             2                                      4   |             
      Hematopoietic Cell Proliferation     |                         4  1              1     2                 1      |             
      Pigmentation, Hemosiderin            |    2     2                          2     2  2        3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|             
                             DAY ON TEST   | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|             
                                           | 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Dilatation                           | 2     2              2                                                   |             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                                              2           1  2           2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hemorrhage                           |                                                                   4      |             
      Hyperkeratosis                       |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Subcutaneous Tissue, Thrombosis      |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    3     2  3  1                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                                      3                 3|             
      Hemorrhage                           |                   2                                                      |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                         2|             
      Hemorrhage                           |                                  1                                       |             
      Infiltration Cellular, Histiocyte    |          1                       1           1        1     1        1   |             
      Inflammation, Subacute               |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                       3                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |                2        2        3  2        1                           |             
      Goblet Cell, Hyperplasia             |             1                    1     1                             1   |             
      Mucosa, Hyperplasia                  |                2        2        2  1        2        2                  |             
      Mucosa, Metaplasia, Squamous         |                2        2        3  2                 2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +              +                 +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 7| 8| 4| 7| 6| 4| 6| 7| 8| 8| 6| 6| 7| 6| 6| 8| 7| 5| 5| 7| 8|             
                             DAY ON TEST   | 3| 8| 0| 4| 0| 5| 2| 3| 4| 8| 2| 0| 5| 5| 4| 6| 6| 2| 2| 5| 3| 0| 5| 1| 0|             
                                           | 2| 6| 7| 7| 2| 7| 3| 0| 7| 7| 6| 2| 7| 7| 7| 8| 6| 6| 7| 7| 0| 8| 1| 9| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.5%                                   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 3  3  3        3        3                                                |             
      Inflammation, Suppurative            |       1     1  1     1              1           1           2     1      |             
      Mineralization                       |                                                                   1      |             
      Nephropathy                          | 4  4  3  4  4  4  1  3  3  2  1  3  3  3  3  3  2  2  3  3  3  2  3  3  3|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Pigmentation           |                      2  4     2                             3            |             
      Transitional Epithelium, Hyperplasia |    2  1  2  2  1        1           2                                1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 4| 6| 8| 6| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3|                                            |            |
                                           | 0| 9| 1| 7| 5| 7| 1| 5| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  3.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      1  4.0|
      Hemorrhage                           |                            3                                             |      1  3.0|
      Parasite Metazoan                    |                X                                                         |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      3  2.7|
      Parasite Metazoan                    |                X                                                         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Epithelium, Hyperplasia              | 3              3                                                         |      4  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                2                                                         |      7  2.0|
      Basophilic Focus                     |                2                                                         |      7  1.6|
      Clear Cell Focus                     |                                                                          |      5  1.2|
      Degeneration, Cystic                 |                                                                          |      5  2.2|
      Eosinophilic Focus                   |                3                                                         |      4  2.3|
      Hepatodiaphragmatic Nodule           |                   X     X                                                |      8     |
      Mixed Cell Focus                     |                                                                          |      2  3.0|
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |       2  2  2     3  2  3                                                |     25  2.6|
      Centrilobular, Fibrosis              |                                                                          |      1  3.0|
      Centrilobular, Necrosis              |                            1                                             |      2  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      3  2.7|
      Kupffer Cell, Pigmentation           |             1                                                            |     10  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                    +                                                |  16        |
      Accessory Spleen                     |                                                                          |      4     |
      Fat, Necrosis                        |    3                    3                                                |     13  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |             3                                                            |     15  1.8|
      Acinus, Cytoplasmic Alteration       |                3                                                         |      4  3.3|
      Acinus, Hyperplasia, Focal           |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 4| 6| 8| 6| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3|                                            |            |
                                           | 0| 9| 1| 7| 5| 7| 1| 5| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |                                                                          |      6  2.7|
      Hyperplasia                          | 3              3                                                         |     12  2.8|
      Ulcer                                | 4              3                                                         |      7  3.4|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      3  2.0|
      Erosion                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                +                                                         |   4        |
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypertrophy                          |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2  2     2  2  2  3  1                                                   |     37  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                3        1                                                |     13  1.3|
      Degeneration, Fatty                  |                                                                          |      7  1.4|
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia, Focal                   |    2                                                                     |      3  2.7|
      Hypertrophy, Focal                   |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          | 3                       1                                                |     12  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  58        |
      Hyperplasia                          | 3              3                                                         |      9  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nuclear Alteration                   |    2                                                                     |      1  2.0|
      Pars Distalis, Cyst                  |          3     3                                                         |      7  3.0|
      Pars Distalis, Hyperplasia, Focal    |          1     3        1                                                |     14  2.2|
      Pars Intermedia, Angiectasis         |                                                                          |      1  3.0|
      Pars Intermedia, Cyst                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |    3                                                                     |      5  3.0|
      C-Cell, Hyperplasia                  |                                                                          |      7  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 4| 6| 8| 6| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3|                                            |            |
                                           | 0| 9| 1| 7| 5| 7| 1| 5| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Peritoneum                              |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atypia Cellular                      |       3           3                                                      |     25  3.0|
      Granuloma Sperm                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      4  3.0|
      Hyperplasia                          |                                                                          |      2  1.5|
      Inflammation, Chronic                | 2              2                                                         |     12  2.0|
      Inflammation, Suppurative            |       1                                                                  |      5  2.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |       1     1  2  2        2                                             |     23  1.9|
      Epithelium, Hyperplasia              |             1                                                            |      8  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Interstitial Cell, Hyperplasia       |                                                                          |      3  1.3|
      Seminiferous Tubule, Atrophy         |                                                                          |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      7  2.9|
      Infiltration Cellular, Histiocyte    | 2                                                                        |      2  2.0|
      Myelofibrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +        +  +                                                |  35        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  4.0|
      Mediastinal, Congestion              | 1                                                                        |      2  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      3  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.0|
      Mediastinal, Pigmentation            |                      3  3                                                |     16  3.0|
      Pancreatic, Hyperplasia, Plasma Cell | 2                                                                        |      1  2.0|
      Pancreatic, Pigmentation             |                         3                                                |      3  3.0|
      Renal, Ectasia                       | 3                                                                        |      2  3.0|
      Renal, Hemorrhage                    | 3                                                                        |      2  3.0|
      Renal, Pigmentation                  | 3                                                                        |      7  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                2                                                         |      6  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 4| 6| 8| 6| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3|                                            |            |
                                           | 0| 9| 1| 7| 5| 7| 1| 5| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      3  2.3|
      Hyperplasia, Lymphoid                |                3           2                                             |     17  2.5|
      Pigmentation                         |                            2                                             |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectasia                              |                   3     4                                                |     10  3.1|
      Hemorrhage                           |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |    3  3                                                                  |     13  2.7|
      Hematopoietic Cell Proliferation     |                            2                                             |      8  2.0|
      Pigmentation, Hemosiderin            |                2           2                                             |     12  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Dilatation                           |    1     2        1                                                      |     10  1.7|
      Galactocele                          |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                          |      6  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
      Subcutaneous Tissue, Thrombosis      |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               | 3              2                                                         |      7  2.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      3  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 6| 4| 6| 8| 6| 6| 7| 5|                                            |            |
                             DAY ON TEST   | 1| 3| 2| 8| 7| 5| 9| 5| 7| 3|                                            |            |
                                           | 0| 9| 1| 7| 5| 7| 1| 5| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.5%                                   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |          2                                                               |      2  1.5|
      Infiltration Cellular, Histiocyte    | 1              1  3                                                      |     14  1.2|
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                            2                                             |      7  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      2     |
      Inflammation, Suppurative            |    1                                                                     |     11  1.8|
      Goblet Cell, Hyperplasia             | 1              1                                                         |     13  1.1|
      Mucosa, Hyperplasia                  |                                                                          |     10  1.8|
      Mucosa, Metaplasia, Squamous         |                                                                          |      7  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Atrophy                              |                                                                          |      1  4.0|
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 | 3  3           3     3                                                   |     11  3.0|
      Inflammation, Suppurative            | 1           1        1  2  1                                             |     20  1.2|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          | 4  4  2  2  3  4  3  3  3  3                                             |     60  2.8|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                   2                                                      |      1  2.0|
      Renal Tubule, Atrophy                |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |          2        3     2                                                |     15  2.5|
      Transitional Epithelium, Hyperplasia | 2  2        1  2     1  1                                                |     21  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|             
                             DAY ON TEST   | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|             
                                           | 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X        X                                X  X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                    X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2                                                                        |             
      Parasite Metazoan                    |          X                                            X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                       3           3      |             
      Basophilic Focus                     |                                        2                 1  1            |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                   2              3           3                    3      |             
      Eosinophilic Focus                   |                      2        2        2                                 |             
      Hemorrhage                           |                                                 3                        |             
      Hepatodiaphragmatic Nodule           |       X        X                                         X               |             
      Necrosis, Focal                      | 2  2                                               3                     |             
      Thrombosis                           |       3                                                                  |             
      Bile Duct, Hyperplasia               | 3  3  3  2  4  2  3     3  3     2  1  2     3  2  4  1     2  3  3  2  4|             
      Centrilobular, Necrosis              |       3                                         2                        |             
      Hepatocyte, Vacuolization Cytoplasmic|             3                                                  3         |             
      Kupffer Cell, Pigmentation           |       4     2     1           3                    3           2     2   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +           +        +     +  +                                +|             
      Accessory Spleen                     |                      X                                                  X|             
      Fat, Necrosis                        | 2        2                    3     3  3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2  4     1                    2  3        2     2           1  3      |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                   3                                                      |             
      Erosion                              |                   2                                                      |             
      Hyperplasia                          |       1           2                          3  2                        |             
      Inflammation, Subacute               |                                                                2         |             
      Ulcer                                |                                           3  4                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|             
                             DAY ON TEST   | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|             
                                           | 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |    1        1  2        3                    1        2                  |             
      Ulcer                                |       3                                   2                              |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                                                  |             
      Epithelium, Hyperplasia              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3     2  2  3        2     2  2     3  3     1           3     2     3  3|             
      Thrombosis                           |       4                                      4                 3         |             
      Schwann Cell, Hyperplasia            |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    | 1     3  2                             2              2     2        2  2|             
      Degeneration, Fatty                  |                                                                          |             
      Hemorrhage                           |                                        3     3                           |             
      Hyperplasia, Focal                   |                                     2                                    |             
      Hypertrophy, Focal                   |    1        3                          2                                 |             
      Necrosis                             |                                              3                           |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  1  3  1  3                 2  2     1        4     3     1  2  3     1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3              2                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                     2  3                                 |             
      Pars Distalis, Cyst                  |                                        3                                 |             
      Pars Distalis, Hyperplasia, Focal    |    1           2                          1              2        2      |             
      Pars Intermedia, Cyst                |    3        3           3                             3                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                      2                                   2              1|             
      Follicle, Cyst                       |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |          3  3  3           3        3  3  3     3     3  3     3  3      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|             
                             DAY ON TEST   | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|             
                                           | 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |       1     2  1                    2        2                 2     2  2|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2                                                                     |             
      Inflammation, Suppurative            |                2     2     3     2  1  2        1        1  2     3  1  2|             
      Epithelium, Hyperplasia              |          2                 3  2                          2  1           1|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                    2                     |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Myelofibrosis                        |             2                                                  3         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +  +        +  +  +           +  +  +  +  +     +     +  +   |             
      Mediastinal, Hemorrhage              |             3                                                        3   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Pigmentation            |             3                 3           2     4           3        2   |             
      Pancreatic, Pigmentation             |                                                                   3      |             
      Renal, Pigmentation                  |                            4                 4                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                   2                 2  2                 2     3         |             
      Hemorrhage                           |                                                 2                        |             
      Hyperplasia, Lymphoid                |          3        2  3                                   2           2   |             
      Pigmentation                         |                      3        2  2  2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                3         |             
      Hemorrhage                           |                   3                          2  3                        |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  4                                       |             
      Fibrosis                             |       3           3                    3                 3  4           3|             
      Hematopoietic Cell Proliferation     |                   2                             3                        |             
      Necrosis                             |       2     3                                      3                     |             
      Pigmentation, Hemosiderin            |                      3        3                 2        3  3           2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Dilatation                           | 1  2  2     3        2     2     1           2     1                 2  2|             
      Hyperplasia                          |                   2           2     1  1                          2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|             
                             DAY ON TEST   | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|             
                                           | 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                          2               |             
      Femur, Osteopetrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                      4        2                                         3|             
      Hydrocephalus                        | 2                    3                                                   |             
      Necrosis                             |             2              2                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |             1        1              1        2     3  1                 1|             
      Alveolar Epithelium, Hyperplasia     |                      1                                      1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |             X                    X           X                    X      |             
      Inflammation, Suppurative            |             3     3              2     2     2                    2      |             
      Goblet Cell, Hyperplasia             |                   1        1                 1                           |             
      Mucosa, Hyperplasia                  |             3     2              2           2                    2      |             
      Mucosa, Metaplasia, Squamous         |                                  2     3                          1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                      +   |             
      Cataract                             |                                                                      3   |             
      Inflammation, Chronic                |                                                                          |             
      Retina, Degeneration                 |                                                                      3   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 8| 8| 8| 8| 6| 6| 6| 6| 7| 8| 6| 8| 8| 6| 8| 8| 7| 6| 8| 8| 7| 8| 7| 8|             
                             DAY ON TEST   | 1| 5| 2| 5| 3| 1| 7| 6| 5| 1| 5| 7| 5| 5| 2| 3| 0| 6| 9| 5| 1| 5| 5| 6| 5|             
                                           | 7| 0| 7| 7| 1| 3| 2| 1| 1| 2| 7| 5| 7| 7| 5| 7| 7| 5| 1| 7| 0| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       | 1              1                       1  1              2               |             
      Nephropathy                          | 2  2  2  2  2     2  3  2  1  3  2  2  1  1  2  3  3  2  4  2  1  2  3  3|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                            2                                             |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Necrosis               |                         3                                                |             
      Renal Tubule, Pigmentation           | 2  2  2     3  2        2  2     2     2           2           2  2      |             
      Transitional Epithelium, Hyperplasia |                                                          1               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|             
                                           | 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Parasite Metazoan                    |                                     X        X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                             X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1        3                           |             
      Basophilic Focus                     |                            2              1                 2            |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                  3                                       |             
      Degeneration, Cystic                 |             1  1                                   3     2              1|             
      Eosinophilic Focus                   |                                     3                          3         |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Necrosis, Focal                      |    1                 3                                                   |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 3  2  2     3  3  2     1     2  3  2  2  1        3  3  2  3  3  1  2  2|             
      Centrilobular, Necrosis              |                                                                      2   |             
      Hepatocyte, Vacuolization Cytoplasmic|          3     3     3        3        1              2                  |             
      Kupffer Cell, Pigmentation           | 3           2        2                 4              2           2      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +                    +           +                 +              +   |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        | 4  3                    2           3                                3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2           3     2  3  2  2     2              3                 1   |             
      Acinus, Cytoplasmic Alteration       |                                                                          |             
      Acinus, Hyperplasia, Focal           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                       2                  |             
      Inflammation, Subacute               |                                                                          |             
      Ulcer                                |                   3     4                             4  2        3  2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|             
                                           | 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              | 3     2  3                                                        4      |             
      Ulcer                                |                                                          3           3   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1     2     2  2  2     1  2     1  2     1     2  3  3  2        2   |             
      Thrombosis                           | 3              4                 4     4                          3      |             
      Schwann Cell, Hyperplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   2     3           2                          3         |             
      Degeneration, Fatty                  |          3                 2                                      3      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy, Focal                   |       1                                                  2               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  1     2              2  1     2              1  2        3  3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  | 3     3                          3        3        3           3        3|             
      Pars Distalis, Hyperplasia, Focal    |                         2              2                                 |             
      Pars Intermedia, Cyst                |                         3              3  3                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                     3                          3     3   |             
      C-Cell, Hyperplasia                  |       3                                1                                 |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |       3  3              3  3  3           3  3           3  3     3      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|             
                                           | 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                     2                                    |             
      Inflammation, Chronic                |                               2           2  2                           |             
      Inflammation, Suppurative            |                1                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Suppurative            |    2  3        4     1  1  1                 3  2  1                     |             
      Epithelium, Hyperplasia              | 1     1        2                       2                                 |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |    2                                                                     |             
      Seminiferous Tubule, Atrophy         |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                   3      |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +  +  +  +           +  +                    +  +  +  +      |             
      Mediastinal, Hemorrhage              |                                                                   3      |             
      Mediastinal, Hyperplasia, Lymphoid   |                                  2                                       |             
      Mediastinal, Pigmentation            |    3        3                    3  3                             3      |             
      Pancreatic, Pigmentation             |             3                                                     3      |             
      Renal, Pigmentation                  |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |       2                                                                 3|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                         4                    2                    3      |             
      Pigmentation                         |                            2        2        2              2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           3                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis                             |                4  2  2  3     2        2           3  3     2  2     2   |             
      Hematopoietic Cell Proliferation     |                         2  1                 2                           |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                         3                    2                    2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Dilatation                           | 1  2        2  2  3  2        2  2     2                          2      |             
      Hyperplasia                          |       3                 2  1                 2           3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|             
                                           | 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |             2                                                            |             
      Inflammation, Chronic                |                                                                          |             
      Epidermis, Hyperplasia               |             2                                                            |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Femur, Osteopetrosis                 |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Atrophy                              |    3                                                                     |             
      Hydrocephalus                        |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |    2                 1     1     4     1     1           3  1            |             
      Alveolar Epithelium, Hyperplasia     |                2                 4                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                      X   |             
      Inflammation, Suppurative            |                      2                             2                 2   |             
      Goblet Cell, Hyperplasia             |                                                                      1   |             
      Mucosa, Hyperplasia                  |                                                                      2   |             
      Mucosa, Metaplasia, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                   +                                                      |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                    +                           |             
      Cataract                             |                                                                          |             
      Inflammation, Chronic                |                         4                                                |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 8| 6| 8| 8| 7| 7| 8| 8| 6| 8| 8| 8| 5| 6| 3| 7| 7| 7| 5| 7| 8| 7| 7|             
                             DAY ON TEST   | 2| 0| 5| 1| 2| 2| 4| 3| 5| 5| 9| 3| 5| 3| 7| 6| 7| 5| 0| 8| 9| 2| 1| 1| 1|             
                                           | 0| 2| 7| 3| 1| 9| 9| 5| 7| 7| 4| 7| 7| 9| 7| 7| 5| 8| 1| 6| 1| 2| 4| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.0%                                   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       | 1     1        1                 1           1           2               |             
      Nephropathy                          |    1  3  1  2  2  2  1  3  3  2  2  3  2     1     1  3  2  1  1  2  1  1|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |             2                                                            |             
      Renal Tubule, Atrophy                |                                                                         4|             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |             2  3     2  1     2        2           2        3            |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 7| 6| 8| 8| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3|                                            |            |
                                           | 7| 0| 8| 1| 2| 3| 2| 0| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  M  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                   X                                                      |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                2                                                         |      2  2.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Diverticulum                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |          2                                                               |      5  2.4|
      Basophilic Focus                     | 2                                                                        |      7  1.6|
      Clear Cell Focus                     |                         3                                                |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Cystic                 |                                                                          |      9  2.1|
      Eosinophilic Focus                   | 3                                                                        |      6  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                   X                                                      |      4     |
      Necrosis, Focal                      |    3                                                                     |      6  2.3|
      Thrombosis                           |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |    3  2  1  2  3     1                                                   |     47  2.4|
      Centrilobular, Necrosis              |                                                                          |      3  2.3|
      Hepatocyte, Vacuolization Cytoplasmic|                   1                                                      |      9  2.4|
      Kupffer Cell, Pigmentation           |    3              2                                                      |     15  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        +                                                      |  15        |
      Accessory Spleen                     |                                                                          |      2     |
      Fat, Necrosis                        |          3        4                                                      |     12  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |          1                                                               |     19  2.2|
      Acinus, Cytoplasmic Alteration       |                            3                                             |      1  3.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |    2                                                                     |      2  2.5|
      Erosion                              |                         1                                                |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 7| 6| 8| 8| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3|                                            |            |
                                           | 7| 0| 8| 1| 2| 3| 2| 0| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |    1                 1                                                   |      7  1.7|
      Inflammation, Subacute               |                         1                                                |      2  1.5|
      Ulcer                                |    3                 3                                                   |     10  3.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |    2                                                                     |      2  2.0|
      Erosion                              |       3                                                                  |     11  2.3|
      Ulcer                                |    3                                                                     |      5  2.8|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   2        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2     3  2  2  2  3  3  3                                                |     38  2.2|
      Thrombosis                           |                   1                                                      |      9  3.3|
      Schwann Cell, Hyperplasia            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |             3           1                                                |     14  2.1|
      Degeneration, Fatty                  | 2  1        2     2                                                      |      7  2.1|
      Hemorrhage                           |                   3                                                      |      3  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      5  1.8|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          | 1  2        1     3  1     3                                             |     30  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  +  +                                             |  57        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.5|
      Pars Distalis, Cyst                  |                            3                                             |      9  3.0|
      Pars Distalis, Hyperplasia, Focal    |       1        3           2                                             |     10  1.8|
      Pars Intermedia, Cyst                |    3                                                                     |      8  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ultimobranchial Cyst                 |                                                                          |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 7| 6| 8| 8| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3|                                            |            |
                                           | 7| 0| 8| 1| 2| 3| 2| 0| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                         3                                                |      6  2.0|
      Follicle, Cyst                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atypia Cellular                      | 3     3  3  3     3     3  3                                             |     29  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |             2                                                            |     12  1.8|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            | 2     2  3        2  2  2  2                                             |     28  2.0|
      Epithelium, Hyperplasia              | 1        3                                                               |     12  1.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Interstitial Cell, Hyperplasia       |                1                                                         |      3  1.7|
      Seminiferous Tubule, Atrophy         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Depletion Cellular                   |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +  +  +        +                                             |  33        |
      Mediastinal, Hemorrhage              |                                                                          |      3  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                   2                                                      |      2  2.0|
      Mediastinal, Pigmentation            |             3  3  3                                                      |     14  2.9|
      Pancreatic, Pigmentation             |                            3                                             |      4  3.0|
      Renal, Pigmentation                  |             4  3                                                         |      5  3.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectasia                              |    2                                                                     |      8  2.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 2                 3     2                                                |     11  2.5|
      Pigmentation                         |                                                                          |      8  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ectasia                              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 7| 6| 8| 8| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3|                                            |            |
                                           | 7| 0| 8| 1| 2| 3| 2| 0| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  4.0|
      Fibrosis                             |          3           2                                                   |     19  2.7|
      Hematopoietic Cell Proliferation     | 2                                                                        |      6  2.0|
      Necrosis                             |                                                                          |      3  2.7|
      Pigmentation, Hemosiderin            | 3                    1                                                   |     11  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  M  M  +  +                                             |  55        |
      Cyst                                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Dilatation                           |    1        1  2  2  2     1                                             |     27  1.8|
      Hyperplasia                          | 3        3                                                               |     12  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Chronic                |                   4                                                      |      1  4.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
      Femur, Osteopetrosis                 |    2                                                                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  3.0|
      Atrophy                              |          3           3                                                   |      6  3.0|
      Hydrocephalus                        |                      2                                                   |      3  2.3|
      Necrosis                             |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Edema                                |                                                                          |      1  2.0|
      Hemorrhage                           |       2                    1                                             |      2  1.5|
      Infiltration Cellular, Histiocyte    | 1                          3                                             |     17  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05217-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        T-BUTYLHYDROQUINONE                                    Date: 03/30/95  
Route: DOSED FEED                                                                                                 Time: 20:44:01  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 8| 7| 6| 8| 8| 6| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 3| 4| 2| 7| 5| 1| 5| 3|                                            |            |
                                           | 7| 0| 8| 1| 2| 3| 2| 0| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.0%                                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |    2                       3                                             |      6  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      5     |
      Inflammation, Suppurative            |                   1                                                      |     10  2.1|
      Goblet Cell, Hyperplasia             |                                                                          |      4  1.0|
      Mucosa, Hyperplasia                  |       2           1                                                      |      8  2.0|
      Mucosa, Metaplasia, Squamous         |       1                                                                  |      4  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   4        |
      Cataract                             |                3                                                         |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Retina, Degeneration                 |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |     11  1.2|
      Nephropathy                          | 3  3  1  3  1  1  3  2  2  1                                             |     56  2.0|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |             2                                                            |      3  2.0|
      Renal Tubule, Atrophy                |                                                                          |      1  4.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |    2        3              2                                             |     23  2.1|
      Transitional Epithelium, Hyperplasia | 2                                                                        |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |       3                                                                  |      1  3.0|
      Inflammation, Suppurative            |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------