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NTP Study C06111 Pathology Tables

                                            STATISTICAL ANALYSIS OF SURVIVAL DATA

                                            BENZYL ALCOHOL BY GAVAGE                                                

                                            CONTRACT NUMBER:      600262

                                            CHEMICAL NUMBER(S):   C06111              

                                            SPECIES:              RATS    MICE            




                                                 KAPLAN-MEIER ANALYSIS   
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  1   DOSE= (      0.0)  VEHICLE                 

 MEDIAN BIRTH DATE: 01/30/81                       600262 RG 14VM MALE RATS       C06111                             
 START OF STUDY:    03/30/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

    4:C95   59:C63   70:C89   76:C60   86:C78   89:C65   89:C84   91:C67   93:C68   94:C58   94:C96   95:C73   95:C97   96:C53 
 98:C87   99:C57  101:C82  102:C51 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

   11:100   60:C59   81:C69   85:C81

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C52  104:C54  104:C55  104:C56  104:C61  104:C62  104:C64  104:C66  104:C70  104:C71  104:C72  104:C74  104:C75  104:C76
 104:C77  104:C79  104:C80  104:C83  104:C85  104:C86  104:C88  104:C90  104:C91  104:C92  104:C93  104:C94  104:C98  104:C99



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              18

                                       ACCIDENTAL DEATH OR MISSING:                       4

                                       SCHEDULED OR TERMINAL SACRIFICE:                  28

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  2   DOSE= (  40000.0)  LOW DOSE                

 MEDIAN BIRTH DATE: 01/30/81                       600262 RG 14LM MALE RATS       C06111                             
 START OF STUDY:    03/30/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   15:C78   24:C95   79:C88   89:C59   89:C72   91:C83   97:C94   98:C68   99:C76  100:100  100:C84  101:C80  102:C60  102:C89 
103:C92 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

   16:C97   21:C57   40:C56   41:C66   41:C79   42:C71   49:C93   55:C77

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C51  104:C52  104:C53  104:C54  104:C55  104:C58  104:C61  104:C62  104:C63  104:C64  104:C65  104:C67  104:C69  104:C70
 104:C73  104:C74  104:C75  104:C81  104:C82  104:C85  104:C86  104:C87  104:C90  104:C91  104:C96  104:C98  104:C99



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              15

                                       ACCIDENTAL DEATH OR MISSING:                       8

                                       SCHEDULED OR TERMINAL SACRIFICE:                  27

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  3   DOSE= (  80000.0)  HIGH DOSE               

 MEDIAN BIRTH DATE: 01/30/81                       600262 RG 14HM MALE RATS       C06111                             
 START OF STUDY:    03/30/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   55:C89   65:C99   75:C91   78:C83   80:C72   89:C66   92:C96   93:C69   95:C61   96:C51  100:C58  103:C64 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    0:C81    1:C52    9:C54    9:C62   48:C68   48:C78   48:C90   49:C55   57:C93   85:C59   95:C79   97:C98   98:C71   98:C87

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:100  104:C53  104:C56  104:C57  104:C60  104:C63  104:C65  104:C67  104:C70  104:C73  104:C74  104:C75  104:C76  104:C77
 104:C80  104:C82  104:C84  104:C85  104:C86  104:C88  104:C92  104:C94  104:C95  104:C97



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              12

                                       ACCIDENTAL DEATH OR MISSING:                      14

                                       SCHEDULED OR TERMINAL SACRIFICE:                  24

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  1      600262 RG 14VM MALE RATS       C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
         4      0.980      0.020                           4   0.980      0.020             49
        59      0.960      0.028                          59   0.940      0.034             47
        70      0.939      0.034                          70   0.900      0.042             45
        76      0.918      0.039                          76   0.880      0.046             44
        86      0.896      0.044                          86   0.820      0.054             41
        89      0.852      0.052                          89   0.780      0.059             39
        91      0.830      0.055                          91   0.760      0.060             38
        93      0.809      0.058                          93   0.740      0.062             37
        94      0.765      0.062                          94   0.700      0.065             35
        95      0.721      0.066                          95   0.660      0.067             33
        96      0.699      0.067                          96   0.640      0.068             32
        98      0.677      0.069                          98   0.620      0.069             31
        99      0.656      0.070                          99   0.600      0.069             30
       101      0.634      0.071                         101   0.580      0.070             29
       102      0.612      0.072                         102   0.560      0.070             28
                                                         104   0.560      0.070             28   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  2      600262 RG 14LM MALE RATS       C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        15      0.980      0.020                          15   0.980      0.020             49
        24      0.959      0.028                          24   0.920      0.038             46
        79      0.935      0.036                          79   0.780      0.059             39
        89      0.887      0.048                          89   0.740      0.062             37
        91      0.863      0.052                          91   0.720      0.063             36
        97      0.839      0.056                          97   0.700      0.065             35
        98      0.815      0.059                          98   0.680      0.066             34
        99      0.791      0.062                          99   0.660      0.067             33
       100      0.743      0.067                         100   0.620      0.069             31
       101      0.719      0.069                         101   0.600      0.069             30
       102      0.671      0.072                         102   0.560      0.070             28
       103      0.647      0.074                         103   0.540      0.070             27
                                                         104   0.540      0.070             27   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  3      600262 RG 14HM MALE RATS       C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        55      0.976      0.024                          55   0.820      0.054             41
        65      0.952      0.033                          65   0.780      0.059             39
        75      0.927      0.040                          75   0.760      0.060             38
        78      0.903      0.046                          78   0.740      0.062             37
        80      0.879      0.051                          80   0.720      0.063             36
        89      0.853      0.055                          89   0.680      0.066             34
        92      0.828      0.059                          92   0.660      0.067             33
        93      0.803      0.062                          93   0.640      0.068             32
        95      0.778      0.065                          95   0.620      0.069             31
        96      0.752      0.068                          96   0.580      0.070             29
       100      0.723      0.071                         100   0.500      0.071             25
       103      0.694      0.074                         103   0.480      0.071             24
                                                         104   0.480      0.071             24   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88        GRAPH   1     600262     MALE RATS           C06111                                   RUN DATE 02/08/96

        0        15        30        45        60        75        90       105       120       135       150
        +         +         +         +         +         +         +         +         +         +         +
        -----------------------------------------------------------------------------------------------------
    1.0+***********333333333333333333333333333                                                                  
       +   1111111*******11111111111111111111***3333                                                            
       +                22222222222222222222222************222                                                  
       +                                               111*1 2222222                                            
       +                                                  3**11111 2                                            
     .9+                                                    33   11*                                            
  P    +                                                     333333*22                                          
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  A  .8+                                                              **  22                                    
  B    +                                                               *3  2                                    
  I    +                                                               1333*                                    
  L    +                                                               1   *                                    
  I    +                                                               11  **3                                  
  T  .7+                                                                11  23                                  
  Y    +                                                                 11 22                                  
       +                                                                  11 2                                  
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        -----------------------------------------------------------------------------------------------------
        +         +         +         +         +         +         +         +         +         +         +
        0        15        30        45        60        75        90       105       120       135       150
                                                       WEEKS ON STUDY  
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                               600262     MALE RATS           C06111                                   

                                              STATISTICAL ANALYSIS OF SURVIVAL DATA

                                                            MEAN
                                                          SURVIVAL         STANDARD         STANDARD
                               GROUP       ANIMALS        IN WEEKS        DEVIATION          ERROR

                                 1           50              93.7            21.04            2.976

                                 2           50              88.1            28.16            3.982

                                 3           50              85.2            29.85            4.222

                                                         LIFE TABLE ANALYSIS

                                              GROUP          CHI-SQUARE      P-VALUE

                                              1 VS.  2        0.1219         0.7270

                                              1 VS.  3        0.2921         0.5889

                                              2 VS.  3        0.0038         0.9506

                                              TREND           0.4214         0.5162
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  1   DOSE= (      0.0)  VEHICLE                 

 MEDIAN BIRTH DATE: 01/30/81                       600262 RG 14VF FEMALE RATS     C06111                             
 START OF STUDY:    03/30/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   76:C90   82:C60   86:C64   89:C87   91:C63   96:C68   99:C52   99:C93   99:C98  101:C81  102:C97  103:C59  103:C61 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

   95:C86

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:100  104:C51  104:C53  104:C54  104:C55  104:C56  104:C57  104:C58  104:C62  104:C65  104:C66  104:C67  104:C69  104:C70
 104:C71  104:C72  104:C73  104:C74  104:C75  104:C76  104:C77  104:C78  104:C79  104:C80  104:C82  104:C83  104:C84  104:C85
 104:C88  104:C89  104:C91  104:C92  104:C94  104:C95  104:C96  104:C99



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              13

                                       ACCIDENTAL DEATH OR MISSING:                       1

                                       SCHEDULED OR TERMINAL SACRIFICE:                  36

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  2   DOSE= (  40000.0)  LOW DOSE                

 MEDIAN BIRTH DATE: 01/30/81                       600262 RG 14LF FEMALE RATS     C06111                             
 START OF STUDY:    03/30/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

    0:C55    9:C94   16:C63   23:C65   44:C61   68:C64   71:C51   78:100   81:C91   83:C87   88:C99   89:C72   94:C70   99:C67 
 99:C68  103:C95 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

   16:C84   16:C93   23:C56   23:C97   24:C60   40:C69   44:C76   44:C89   49:C54   50:C82   52:C57   53:C62   53:C78   54:C53
  56:C59  102:C80  104:C83

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C52  104:C58  104:C66  104:C71  104:C73  104:C74  104:C75  104:C77  104:C79  104:C81  104:C85  104:C86  104:C88  104:C90
 104:C92  104:C96  104:C98



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              16

                                       ACCIDENTAL DEATH OR MISSING:                      17

                                       SCHEDULED OR TERMINAL SACRIFICE:                  17

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  3   DOSE= (  80000.0)  HIGH DOSE               

 MEDIAN BIRTH DATE: 01/30/81                       600262 RG 14HF FEMALE RATS     C06111                             
 START OF STUDY:    03/30/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   16:C67   23:C56   23:C66   24:C68   28:C60   45:C96   51:C89   59:C77   85:C78   88:C61   93:C86   95:C54   95:C93   97:C72 
 99:C57   99:C80  100:C62  101:C95  102:C59  102:C84 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

   15:C55   17:C97   21:C88   23:C63   41:C64   45:C73   47:C76   48:C85   49:C81   54:100   54:C99   56:C91  103:C79

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C51  104:C52  104:C53  104:C58  104:C65  104:C69  104:C70  104:C71  104:C74  104:C75  104:C82  104:C83  104:C87  104:C90
 104:C92  104:C94  104:C98



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              20

                                       ACCIDENTAL DEATH OR MISSING:                      13

                                       SCHEDULED OR TERMINAL SACRIFICE:                  17

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  1      600262 RG 14VF FEMALE RATS     C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        76      0.980      0.020                          76   0.980      0.020             49
        82      0.960      0.028                          82   0.960      0.028             48
        86      0.940      0.034                          86   0.940      0.034             47
        89      0.920      0.038                          89   0.920      0.038             46
        91      0.900      0.042                          91   0.900      0.042             45
        96      0.880      0.046                          96   0.860      0.049             43
        99      0.818      0.055                          99   0.800      0.057             40
       101      0.798      0.057                         101   0.780      0.059             39
       102      0.777      0.059                         102   0.760      0.060             38
       103      0.736      0.063                         103   0.720      0.063             36
                                                         104   0.720      0.063             36   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  2      600262 RG 14LF FEMALE RATS     C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
         0      0.980      0.020                           0   0.980      0.020             49
         9      0.960      0.028                           9   0.960      0.028             48
        16      0.940      0.034                          16   0.940      0.034             47
        23      0.919      0.039                          23   0.880      0.046             44
        44      0.896      0.044                          44   0.780      0.059             39
        68      0.866      0.052                          68   0.580      0.070             29
        71      0.836      0.058                          71   0.560      0.070             28
        78      0.807      0.063                          78   0.540      0.070             27
        81      0.777      0.067                          81   0.520      0.071             26
        83      0.747      0.071                          83   0.500      0.071             25
        88      0.717      0.074                          88   0.480      0.071             24
        89      0.687      0.077                          89   0.460      0.070             23
        94      0.657      0.079                          94   0.440      0.070             22
        99      0.597      0.083                          99   0.400      0.069             20
       103      0.566      0.084                         103   0.360      0.068             18
                                                         104   0.315      0.073             16   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  3      600262 RG 14HF FEMALE RATS     C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        16      0.980      0.020                          16   0.960      0.028             48
        23      0.937      0.035                          23   0.880      0.046             44
        24      0.915      0.041                          24   0.840      0.052             42
        28      0.893      0.045                          28   0.820      0.054             41
        45      0.871      0.049                          45   0.780      0.059             39
        51      0.846      0.054                          51   0.680      0.066             34
        59      0.819      0.059                          59   0.600      0.069             30
        85      0.792      0.063                          85   0.580      0.070             29
        88      0.764      0.066                          88   0.560      0.070             28
        93      0.737      0.069                          93   0.540      0.070             27
        95      0.682      0.074                          95   0.500      0.071             25
        97      0.655      0.076                          97   0.480      0.071             24
        99      0.601      0.079                          99   0.440      0.070             22
       100      0.573      0.080                         100   0.420      0.070             21
       101      0.546      0.081                         101   0.400      0.069             20
       102      0.491      0.081                         102   0.360      0.068             18
                                                         104   0.340      0.067             17   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88        GRAPH   2     600262     FEMALE RATS         C06111                                   RUN DATE 02/08/96

        0        15        30        45        60        75        90       105       120       135       150
        +         +         +         +         +         +         +         +         +         +         +
        -----------------------------------------------------------------------------------------------------
    1.0+************1111111111111111111111111111111111111111                                                    
       +2222222    33333                                   11111                                                
       +      222222   3                                       111                                              
       +           2222*3                                        111                                            
       +               2****2222222222                             111                                          
     .9+                   3333333333**222222222222222               1111                                       
  P    +                              33333          2                  111                                     
  R    +                                  3          222                  1                                     
  O    +                                  333333       222222             1                                     
  B    +                                       3333333333333*33333        11                                    
  A  .8+                                                    222  333       11                                   
  B    +                                                      22   3        11                                  
  I    +                                                       2   3333      1                                  
  L    +                                                       22222  33     1                                  
  I    +                                                           2   3                                        
  T  .7+                                                           2   3                                        
  Y    +                                                           2222*33                                      
       +                                                               22**                                     
  O    +                                                                  *                                     
  F    +                                                                  *                                     
     .6+                                                                  **22                                  
  S    +                                                                   3 2                                  
  U    +                                                                   3 2                                  
  R    +                                                                   33                                   
  V    +                                                                    3                                   
  I  .5+                                                                    33                                  
  V    +                                                                                                        
  A    +                                                                                                        
  L    +                                                                                                        
       +                                                                                                        
     .4+                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
  K  .3+                                                                                                        
  A    +                                                                                                        
  P    +                                                                                                        
  L    +                                                                                                        
  A    +                                                                                                        
  N  .2+                                                                                                        
       +                                                                                                        
  M    +                                                                                                        
  E    +                                                                                                        
  I    +                                                                                                        
  E  .1+                                                                                                        
  R    +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
     .0+                                                                                                        
        -----------------------------------------------------------------------------------------------------
        +         +         +         +         +         +         +         +         +         +         +
        0        15        30        45        60        75        90       105       120       135       150
                                                       WEEKS ON STUDY  
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                               600262     FEMALE RATS         C06111                                   

                                              STATISTICAL ANALYSIS OF SURVIVAL DATA

                                                            MEAN
                                                          SURVIVAL         STANDARD         STANDARD
                               GROUP       ANIMALS        IN WEEKS        DEVIATION          ERROR

                                 1           50             101.5             6.18            0.874

                                 2           50              72.4            34.25            4.844

                                 3           50              75.5            33.36            4.718

                                                         LIFE TABLE ANALYSIS

                                              GROUP          CHI-SQUARE      P-VALUE

                                              1 VS.  2        3.5779         0.0586

                                              1 VS.  3        6.2279         0.0126

                                              2 VS.  3        0.0817         0.7751

                                              TREND           6.2759         0.0122
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  1   DOSE= (      0.0)  VEHICLE                 

 MEDIAN BIRTH DATE: 11/07/80                       600262 MA 14VM MALE MICE       C06111                             
 START OF STUDY:    01/05/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   21:C40   39:C22   48:C35   54:C08   57:C27   61:C01   67:C03   79:C19   98:C31   99:C47  102:C21  103:C50 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    9:C36   16:C30   53:C09   84:C04

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C02  104:C05  104:C06  104:C07  104:C10  104:C11  104:C12  104:C13  104:C14  104:C15  104:C16  104:C17  104:C18  104:C20
 104:C23  104:C24  104:C25  104:C26  104:C28  104:C29  104:C32  104:C33  104:C34  104:C37  104:C38  104:C39  104:C41  104:C42
 104:C43  104:C44  104:C45  104:C46  104:C48  104:C49



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              12

                                       ACCIDENTAL DEATH OR MISSING:                       4

                                       SCHEDULED OR TERMINAL SACRIFICE:                  34

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  2   DOSE= (  10000.0)  LOW DOSE                

 MEDIAN BIRTH DATE: 11/07/80                       600262 MA 14LM MALE MICE       C06111                             
 START OF STUDY:    01/05/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   66:C21   68:C20   69:C39   75:C38   75:C47   87:C04   92:C13   92:C27   92:C34   95:C14   97:C07 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

   26:C03   36:C41   53:C23   71:C40   83:C26   85:C01

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C02  104:C05  104:C06  104:C08  104:C09  104:C10  104:C11  104:C12  104:C15  104:C16  104:C17  104:C18  104:C19  104:C22
 104:C24  104:C25  104:C28  104:C29  104:C30  104:C31  104:C32  104:C33  104:C35  104:C36  104:C37  104:C42  104:C43  104:C44
 104:C45  104:C46  104:C48  104:C49  104:C50



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              11

                                       ACCIDENTAL DEATH OR MISSING:                       6

                                       SCHEDULED OR TERMINAL SACRIFICE:                  33

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  3   DOSE= (  20000.0)  HIGH DOSE               

 MEDIAN BIRTH DATE: 11/07/80                       600262 MA 14HM MALE MICE       C06111                             
 START OF STUDY:    01/05/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   43:C14   56:C24   57:C27   84:C31   85:C49   94:C29   95:C34   97:C41   99:C16 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    7:C04    8:C10   65:C22   79:C05   95:C01  102:C36

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C02  104:C03  104:C06  104:C07  104:C08  104:C09  104:C11  104:C12  104:C13  104:C15  104:C17  104:C18  104:C19  104:C20
 104:C21  104:C23  104:C25  104:C26  104:C28  104:C30  104:C32  104:C33  104:C35  104:C37  104:C38  104:C39  104:C40  104:C42
 104:C43  104:C44  104:C45  104:C46  104:C47  104:C48  104:C50



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               9

                                       ACCIDENTAL DEATH OR MISSING:                       6

                                       SCHEDULED OR TERMINAL SACRIFICE:                  35

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  1      600262 MA 14VM MALE MICE       C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        21      0.979      0.021                          21   0.940      0.034             47
        39      0.958      0.029                          39   0.920      0.038             46
        48      0.938      0.035                          48   0.900      0.042             45
        54      0.916      0.040                          54   0.860      0.049             43
        57      0.895      0.044                          57   0.840      0.052             42
        61      0.874      0.048                          61   0.820      0.054             41
        67      0.852      0.052                          67   0.800      0.057             40
        79      0.831      0.055                          79   0.780      0.059             39
        98      0.809      0.057                          98   0.740      0.062             37
        99      0.787      0.060                          99   0.720      0.063             36
       102      0.765      0.062                         102   0.700      0.065             35
       103      0.743      0.064                         103   0.680      0.066             34
                                                         104   0.680      0.066             34   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  2      600262 MA 14LM MALE MICE       C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        66      0.979      0.021                          66   0.920      0.038             46
        68      0.957      0.029                          68   0.900      0.042             45
        69      0.936      0.036                          69   0.880      0.046             44
        75      0.893      0.045                          75   0.820      0.054             41
        87      0.870      0.050                          87   0.760      0.060             38
        92      0.801      0.059                          92   0.700      0.065             35
        95      0.778      0.062                          95   0.680      0.066             34
        97      0.755      0.064                          97   0.660      0.067             33
                                                         104   0.660      0.067             33   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  3      600262 MA 14HM MALE MICE       C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        43      0.979      0.021                          43   0.940      0.034             47
        56      0.958      0.029                          56   0.920      0.038             46
        57      0.938      0.035                          57   0.900      0.042             45
        84      0.916      0.040                          84   0.840      0.052             42
        85      0.894      0.045                          85   0.820      0.054             41
        94      0.872      0.049                          94   0.800      0.057             40
        95      0.850      0.052                          95   0.780      0.059             39
        97      0.828      0.055                          97   0.740      0.062             37
        99      0.806      0.058                          99   0.720      0.063             36
                                                         104   0.700      0.065             35   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88        GRAPH   3     600262     MALE MICE           C06111                                   RUN DATE 02/08/96

        0        15        30        45        60        75        90       105       120       135       150
        +         +         +         +         +         +         +         +         +         +         +
        -----------------------------------------------------------------------------------------------------
    1.0+******************************222222222222222                                                           
       +              1111111111111  333333333      22                                                          
       +                          1111111    33      22                                                         
       +                                11111 33333333*****333333                                               
       +                                    111           2     33                                              
     .9+                                      1111        2222222**33333                                        
  P    +                                         11111            2    3                                        
  R    +                                             111111111    2222 333                                      
  O    +                                                     11111111*111*                                      
  B    +                                                             2   *3                                     
  A  .8+                                                             222 1*333                                  
  B    +                                                               222111                                   
  I    +                                                                 222**                                  
  L    +                                                                     1                                  
  I    +                                                                                                        
  T  .7+                                                                                                        
  Y    +                                                                                                        
       +                                                                                                        
  O    +                                                                                                        
  F    +                                                                                                        
     .6+                                                                                                        
  S    +                                                                                                        
  U    +                                                                                                        
  R    +                                                                                                        
  V    +                                                                                                        
  I  .5+                                                                                                        
  V    +                                                                                                        
  A    +                                                                                                        
  L    +                                                                                                        
       +                                                                                                        
     .4+                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
  K  .3+                                                                                                        
  A    +                                                                                                        
  P    +                                                                                                        
  L    +                                                                                                        
  A    +                                                                                                        
  N  .2+                                                                                                        
       +                                                                                                        
  M    +                                                                                                        
  E    +                                                                                                        
  I    +                                                                                                        
  E  .1+                                                                                                        
  R    +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
     .0+                                                                                                        
        -----------------------------------------------------------------------------------------------------
        +         +         +         +         +         +         +         +         +         +         +
        0        15        30        45        60        75        90       105       120       135       150
                                                       WEEKS ON STUDY  
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                               600262     MALE MICE           C06111                                   

                                              STATISTICAL ANALYSIS OF SURVIVAL DATA

                                                            MEAN
                                                          SURVIVAL         STANDARD         STANDARD
                               GROUP       ANIMALS        IN WEEKS        DEVIATION          ERROR

                                 1           50              90.6            26.15            3.698

                                 2           50              94.0            18.41            2.604

                                 3           50              94.2            22.69            3.209

                                                         LIFE TABLE ANALYSIS

                                              GROUP          CHI-SQUARE      P-VALUE

                                              1 VS.  2        0.0025         0.9599

                                              1 VS.  3        0.2877         0.5917

                                              2 VS.  3        0.1175         0.7317

                                              TREND           0.4416         0.5063
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  1   DOSE= (      0.0)  VEHICLE                 

 MEDIAN BIRTH DATE: 11/07/80                       600262 MA 14VF FEMALE MICE     C06111                             
 START OF STUDY:    01/05/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   19:C20   22:C03   40:C23   65:C16   66:C18   71:C08   71:C27   71:C37   71:C39   75:C46   77:C49   77:C50   83:C11   83:C24 
 85:C40   90:C38   91:C32   95:C36   96:C10  103:C26 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    3:C14    4:C04    5:C06  103:C17

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C01  104:C02  104:C05  104:C07  104:C09  104:C12  104:C13  104:C15  104:C19  104:C21  104:C22  104:C25  104:C28  104:C29
 104:C30  104:C31  104:C33  104:C34  104:C35  104:C41  104:C42  104:C43  104:C44  104:C45  104:C47  104:C48



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              20

                                       ACCIDENTAL DEATH OR MISSING:                       4

                                       SCHEDULED OR TERMINAL SACRIFICE:                  26

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  2   DOSE= (  10000.0)  LOW DOSE                

 MEDIAN BIRTH DATE: 11/07/80                       600262 MA 14LF FEMALE MICE     C06111                             
 START OF STUDY:    01/05/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

    3:C06    4:C40   45:C37   61:C39   63:C38   71:C13   74:C47   76:C43   77:C50   81:C32   82:C11   85:C16   90:C14   91:C18 
 92:C17   96:C04  100:C27  104:C48*

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

   70:C05

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C01  104:C02  104:C03  104:C07  104:C08  104:C09  104:C10  104:C12  104:C15  104:C19  104:C20  104:C21  104:C22  104:C23
 104:C24  104:C25  104:C26  104:C28  104:C29  104:C30  104:C31  104:C33  104:C34  104:C35  104:C36  104:C41  104:C42  104:C44
 104:C45  104:C46  104:C49



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              18

                                       ACCIDENTAL DEATH OR MISSING:                       1

                                       SCHEDULED OR TERMINAL SACRIFICE:                  31

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES

*NOTE: ANIMAL DIED PRIOR TO THE TSAC PERIOD
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                                   GROUP  3   DOSE= (  20000.0)  HIGH DOSE               

 MEDIAN BIRTH DATE: 11/07/80                       600262 MA 14HF FEMALE MICE     C06111                             
 START OF STUDY:    01/05/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   79:C26   91:C15   92:C22   92:C44   93:C24   95:C28  102:C09  102:C48  103:C42 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    3:C10    3:C17    8:C05   21:C04   97:C41

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

  104:C01  104:C02  104:C03  104:C06  104:C07  104:C08  104:C11  104:C12  104:C13  104:C14  104:C16  104:C18  104:C19  104:C20
 104:C21  104:C23  104:C25  104:C27  104:C29  104:C30  104:C31  104:C32  104:C33  104:C34  104:C35  104:C36  104:C37  104:C38
 104:C39  104:C40  104:C43  104:C45  104:C46  104:C47  104:C49  104:C50



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               9

                                       ACCIDENTAL DEATH OR MISSING:                       5

                                       SCHEDULED OR TERMINAL SACRIFICE:                  36

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  1      600262 MA 14VF FEMALE MICE     C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        19      0.979      0.021                          19   0.920      0.038             46
        22      0.957      0.029                          22   0.900      0.042             45
        40      0.936      0.036                          40   0.880      0.046             44
        65      0.915      0.041                          65   0.860      0.049             43
        66      0.894      0.045                          66   0.840      0.052             42
        71      0.809      0.057                          71   0.760      0.060             38
        75      0.787      0.060                          75   0.740      0.062             37
        77      0.745      0.064                          77   0.700      0.065             35
        83      0.702      0.067                          83   0.660      0.067             33
        85      0.681      0.068                          85   0.640      0.068             32
        90      0.660      0.069                          90   0.620      0.069             31
        91      0.638      0.070                          91   0.600      0.069             30
        95      0.617      0.071                          95   0.580      0.070             29
        96      0.596      0.072                          96   0.560      0.070             28
       103      0.574      0.072                         103   0.540      0.070             27
                                                         104   0.520      0.071             26   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  2      600262 MA 14LF FEMALE MICE     C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
         3      0.980      0.020                           3   0.980      0.020             49
         4      0.960      0.028                           4   0.960      0.028             48
        45      0.940      0.034                          45   0.940      0.034             47
        61      0.920      0.038                          61   0.920      0.038             46
        63      0.900      0.042                          63   0.900      0.042             45
        71      0.880      0.046                          71   0.860      0.049             43
        74      0.859      0.049                          74   0.840      0.052             42
        76      0.839      0.052                          76   0.820      0.054             41
        77      0.818      0.055                          77   0.800      0.057             40
        81      0.798      0.057                          81   0.780      0.059             39
        82      0.777      0.059                          82   0.760      0.060             38
        85      0.757      0.061                          85   0.740      0.062             37
        90      0.736      0.063                          90   0.720      0.063             36
        91      0.716      0.064                          91   0.700      0.065             35
        92      0.695      0.066                          92   0.680      0.066             34
        96      0.675      0.067                          96   0.660      0.067             33
       100      0.655      0.068                         100   0.640      0.068             32
       104      0.634      0.069                         104   0.620      0.069             31
                                                         104   0.620      0.069             31   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                               GROUP  3      600262 MA 14HF FEMALE MICE     C06111                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =   104)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        79      0.978      0.022                          79   0.900      0.042             45
        91      0.957      0.030                          91   0.880      0.046             44
        92      0.913      0.042                          92   0.840      0.052             42
        93      0.891      0.046                          93   0.820      0.054             41
        95      0.870      0.050                          95   0.800      0.057             40
       102      0.825      0.056                         102   0.740      0.062             37
       103      0.803      0.059                         103   0.720      0.063             36
                                                         104   0.720      0.063             36   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88        GRAPH   4     600262     FEMALE MICE         C06111                                   RUN DATE 02/08/96

        0        15        30        45        60        75        90       105       120       135       150
        +         +         +         +         +         +         +         +         +         +         +
        -----------------------------------------------------------------------------------------------------
    1.0+**************3333333333333333333333333333333333333333                                                  
       +  22         111                                     333333333                                          
       +   222222222222*************222                              3                                          
       +                           111************11                 3                                          
       +                                         2211                33                                         
     .9+                                          22****              33                                        
  P    +                                               *22             3                                        
  R    +                                               1 222           333333                                   
  O    +                                               1   2                3                                   
  B    +                                               1   2222             33                                  
  A  .8+                                               1111   22             3                                  
  B    +                                                  11   222                                              
  I    +                                                   1     2222                                           
  L    +                                                   11111    22                                          
  I    +                                                       1     2                                          
  T  .7+                                                       111   2222                                       
  Y    +                                                         1111   2222                                    
       +                                                            11     222                                  
  O    +                                                             111     2                                  
  F    +                                                               11                                       
     .6+                                                                111111                                  
  S    +                                                                     1                                  
  U    +                                                                                                        
  R    +                                                                                                        
  V    +                                                                                                        
  I  .5+                                                                                                        
  V    +                                                                                                        
  A    +                                                                                                        
  L    +                                                                                                        
       +                                                                                                        
     .4+                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
  K  .3+                                                                                                        
  A    +                                                                                                        
  P    +                                                                                                        
  L    +                                                                                                        
  A    +                                                                                                        
  N  .2+                                                                                                        
       +                                                                                                        
  M    +                                                                                                        
  E    +                                                                                                        
  I    +                                                                                                        
  E  .1+                                                                                                        
  R    +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
     .0+                                                                                                        
        -----------------------------------------------------------------------------------------------------
        +         +         +         +         +         +         +         +         +         +         +
        0        15        30        45        60        75        90       105       120       135       150
                                                       WEEKS ON STUDY  
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/08/96

                                               600262     FEMALE MICE         C06111                                   

                                              STATISTICAL ANALYSIS OF SURVIVAL DATA

                                                            MEAN
                                                          SURVIVAL         STANDARD         STANDARD
                               GROUP       ANIMALS        IN WEEKS        DEVIATION          ERROR

                                 1           50              85.6            29.41            4.159

                                 2           50              92.0            23.38            3.306

                                 3           50              94.7            26.11            3.693

                                                         LIFE TABLE ANALYSIS

                                              GROUP          CHI-SQUARE      P-VALUE

                                              1 VS.  2        0.2140         0.6437

                                              1 VS.  3        6.2335         0.0125

                                              2 VS.  3        3.5621         0.0591

                                              TREND           6.2955         0.0121

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