NTP Study C55436 Pathology Tables
STATISTICAL ANALYSIS OF SURVIVAL DATA
2,3-DIBROMO-1-PROPANOL BY PAINT
CONTRACT NUMBER: 600259
CHEMICAL NUMBER(S): C55436
SPECIES: RATS MICE
KAPLAN-MEIER ANALYSIS
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 1 DOSE= ( 0.0) VEHICLE
MEDIAN BIRTH DATE: 10/19/81 600259 R1 05VM MALE RATS C55436
START OF STUDY: 12/15/81
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
NONE...
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
48:011 48:012 48:013 48:014 48:015 49:001 49:002 49:003 49:004 49:005 49:021 49:022 49:023 49:024
49:025 49:036 49:037 49:038 49:039 49:040 50:031 50:032 50:033 50:034 50:035 50:041 50:042 50:043
50:044 50:045 50:046 50:047 50:048 50:049 50:050 51:006 51:007 51:008 51:009 51:010 51:016 51:017
51:018 51:019 51:020 51:026 51:027 51:028 51:029 51:030
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 0
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 50
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 2 DOSE= ( 97000.0) LOW DOSE
MEDIAN BIRTH DATE: 10/19/81 600259 R1 05LM MALE RATS C55436
START OF STUDY: 12/15/81
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
41:017 41:021 42:010 44:030 45:006 46:047 47:046 48:020 50:009
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
46:031 48:011 48:012 48:013 48:014 48:015 48:036 48:037 48:038 48:039 48:040 49:026 49:027 49:028
49:029 49:041 49:042 49:043 49:044 49:045 50:001 50:002 50:003 50:004 50:005 50:007 50:008 50:022
50:023 50:024 50:025 51:016 51:018 51:019 51:032 51:033 51:034 51:035 51:048 51:049 51:050
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 9
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 41
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 3 DOSE= ( 192000.0) HIGH DOSE
MEDIAN BIRTH DATE: 10/19/81 600259 R1 05HM MALE RATS C55436
START OF STUDY: 12/15/81
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
23:022 25:011 31:012 34:020 35:006 35:032 35:049 36:039 37:023 38:038 38:043 39:024 41:034 41:035
42:004 42:026 42:045 43:005 43:029 43:031 44:001 44:013 44:018 45:044 46:002 46:027 46:041 46:046
46:048 47:009 47:040 47:042 48:019 50:030
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
42:021 48:003 48:007 48:008 48:010 49:014 49:015 49:016 49:017 49:050 50:025 50:028 50:033 51:036
51:037 51:047
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 34
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 16
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 1 600259 R1 05VM MALE RATS C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 51)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
51 1.000 0.000 50 0.300 0.065 15
51 0.300 0.065 15 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 2 600259 R1 05LM MALE RATS C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 51)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
41 0.960 0.028 41 0.960 0.028 48
42 0.940 0.034 42 0.940 0.034 47
44 0.920 0.038 44 0.920 0.038 46
45 0.900 0.042 45 0.900 0.042 45
46 0.880 0.046 46 0.880 0.046 44
47 0.860 0.049 47 0.840 0.052 42
48 0.839 0.052 48 0.820 0.054 41
50 0.801 0.062 50 0.420 0.070 21
51 0.140 0.049 7 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 3 600259 R1 05HM MALE RATS C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 51)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
23 0.980 0.020 23 0.980 0.020 49
25 0.960 0.028 25 0.960 0.028 48
31 0.940 0.034 31 0.940 0.034 47
34 0.920 0.038 34 0.920 0.038 46
35 0.860 0.049 35 0.860 0.049 43
36 0.840 0.052 36 0.840 0.052 42
37 0.820 0.054 37 0.820 0.054 41
38 0.780 0.059 38 0.780 0.059 39
39 0.760 0.060 39 0.760 0.060 38
41 0.720 0.063 41 0.720 0.063 36
42 0.660 0.067 42 0.660 0.067 33
43 0.598 0.070 43 0.580 0.070 29
44 0.536 0.071 44 0.520 0.071 26
45 0.516 0.071 45 0.500 0.071 25
46 0.413 0.070 46 0.400 0.069 20
47 0.351 0.068 47 0.340 0.067 17
48 0.330 0.067 48 0.320 0.066 16
50 0.283 0.072 50 0.120 0.046 6
51 0.020 0.020 1 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 GRAPH 1 600259 MALE RATS C55436 RUN DATE 02/07/96
0 10 20 30 40 50 60 70 80 90 100
+ + + + + + + + + + +
-----------------------------------------------------------------------------------------------------
1.0+******************************************1111111111
+ 333 2
+ 3333333 22
+ 3333 222
+ 33 22
.9+ 3 22
P + 3 22
R + 33 22
O + 33 222
B + 33 2
A .8+ 3 22
B + 33
I + 333
L + 3
I + 33
T .7+ 3
Y + 3
+ 33
O + 3
F + 3
.6+ 33
S + 3
U + 3
R + 33
V + 33
I .5+ 3
V + 3
A + 3
L + 3
+ 33
.4+ 3
+ 3
+ 33
+ 333
+ 3
K .3+ 3
A + 33
P +
L +
A +
N .2+
+
M +
E +
I +
E .1+
R +
+
+
+
.0+
-----------------------------------------------------------------------------------------------------
+ + + + + + + + + + +
0 10 20 30 40 50 60 70 80 90 100
WEEKS ON STUDY
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
600259 MALE RATS C55436
STATISTICAL ANALYSIS OF SURVIVAL DATA
MEAN
SURVIVAL STANDARD STANDARD
GROUP ANIMALS IN WEEKS DEVIATION ERROR
1 50 49.9 1.09 0.154
2 50 48.7 2.47 0.350
3 50 43.5 6.52 0.922
LIFE TABLE ANALYSIS
GROUP CHI-SQUARE P-VALUE
1 VS. 2 8.0117 0.0046
1 VS. 3 52.2986 0.0000
2 VS. 3 27.6928 0.0000
TREND 62.0152 0.0000
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 1 DOSE= ( 0.0) VEHICLE
MEDIAN BIRTH DATE: 10/19/81 600259 R1 05VF FEMALE RATS C55436
START OF STUDY: 12/15/81
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
25:049 38:026
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
52:001 52:002 52:003 52:004 52:005 52:021 52:022 52:023 52:024 52:025 52:027 52:028 52:029 52:030
52:031 52:032 52:033 52:034 52:035 53:011 53:012 53:013 53:014 53:015 54:041 54:042 54:043 54:044
54:045 54:046 54:047 54:048 54:050 55:006 55:007 55:008 55:009 55:010 55:016 55:017 55:018 55:019
55:020 55:036 55:037 55:038 55:039 55:040
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 2
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 48
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 2 DOSE= ( 78000.0) LOW DOSE
MEDIAN BIRTH DATE: 10/19/81 600259 R1 05LF FEMALE RATS C55436
START OF STUDY: 12/15/81
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
31:025 32:042 39:034 42:029 45:002 46:016 47:035 50:013 51:001 51:017 51:019 51:032 54:033
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
52:003 52:004 52:005 52:006 52:007 52:008 52:009 52:010 52:021 52:022 52:023 52:024 52:046 52:047
52:048 52:049 52:050 53:018 53:020 54:026 54:027 54:028 54:030 54:036 54:037 54:038 54:039 54:040
55:011 55:012 55:014 55:015 55:031 55:041 55:043 55:044 55:045
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 13
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 37
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 3 DOSE= ( 157000.0) HIGH DOSE
MEDIAN BIRTH DATE: 10/19/81 600259 R1 05HF FEMALE RATS C55436
START OF STUDY: 12/15/81
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
31:014 34:022 36:019 38:028 38:044 41:010 41:045 42:020 43:004 43:027 44:016 45:048 46:040 48:018
49:030 49:043 50:011 50:012 50:025 50:034 50:035 50:039 50:047 50:050 51:006 52:002 52:024 52:046
53:001
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
49:036 52:015 53:007 53:008 53:009 53:021 53:023 53:026 53:029 53:031 53:032 53:033 53:037 53:038
53:041 53:042 54:003 54:005 54:017 55:013 55:049
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 29
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 21
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 1 600259 R1 05VF FEMALE RATS C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 55)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
25 0.980 0.020 25 0.980 0.020 49
38 0.960 0.028 38 0.960 0.028 48
55 0.000 0.000 0 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 2 600259 R1 05LF FEMALE RATS C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 55)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
31 0.980 0.020 31 0.980 0.020 49
32 0.960 0.028 32 0.960 0.028 48
39 0.940 0.034 39 0.940 0.034 47
42 0.920 0.038 42 0.920 0.038 46
45 0.900 0.042 45 0.900 0.042 45
46 0.880 0.046 46 0.880 0.046 44
47 0.860 0.049 47 0.860 0.049 43
50 0.840 0.052 50 0.840 0.052 42
51 0.760 0.060 51 0.760 0.060 38
54 0.720 0.069 54 0.360 0.068 18
55 0.000 0.000 0 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 3 600259 R1 05HF FEMALE RATS C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 55)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
31 0.980 0.020 31 0.980 0.020 49
34 0.960 0.028 34 0.960 0.028 48
36 0.940 0.034 36 0.940 0.034 47
38 0.900 0.042 38 0.900 0.042 45
41 0.860 0.049 41 0.860 0.049 43
42 0.840 0.052 42 0.840 0.052 42
43 0.800 0.057 43 0.800 0.057 40
44 0.780 0.059 44 0.780 0.059 39
45 0.760 0.060 45 0.760 0.060 38
46 0.740 0.062 46 0.740 0.062 37
48 0.720 0.063 48 0.720 0.063 36
49 0.680 0.066 49 0.680 0.066 34
50 0.515 0.071 50 0.500 0.071 25
51 0.495 0.071 51 0.480 0.071 24
52 0.433 0.071 52 0.420 0.070 21
53 0.411 0.070 53 0.380 0.069 19
55 0.000 0.000 0 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 GRAPH 2 600259 FEMALE RATS C55436 RUN DATE 02/07/96
0 10 20 30 40 50 60 70 80 90 100
+ + + + + + + + + + +
-----------------------------------------------------------------------------------------------------
1.0+********************************
+ 111111****1111
+ 22***2**1111111111111111
+ 3332222
+ 3 2222
.9+ 3333 22
P + 3 22
R + 33 2222
O + 33 22
B + 3 2
A .8+ 33 2
B + 33 2
I + 33 2222
L + 333 2
I + 33 22
T .7+ 3
Y + 33
+ 3
O + 3
F + 3
.6+ 3
S + 3
U + 3
R + 3
V + 33
I .5+ 33
V + 3
A + 3
L + 33
+ 333
.4+
+
+
+
+
K .3+
A +
P +
L +
A +
N .2+
+
M +
E +
I +
E .1+
R +
+
+
+
.0+
-----------------------------------------------------------------------------------------------------
+ + + + + + + + + + +
0 10 20 30 40 50 60 70 80 90 100
WEEKS ON STUDY
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
600259 FEMALE RATS C55436
STATISTICAL ANALYSIS OF SURVIVAL DATA
MEAN
SURVIVAL STANDARD STANDARD
GROUP ANIMALS IN WEEKS DEVIATION ERROR
1 50 52.7 4.70 0.665
2 50 51.3 5.23 0.739
3 50 49.0 5.87 0.830
LIFE TABLE ANALYSIS
GROUP CHI-SQUARE P-VALUE
1 VS. 2 7.5002 0.0062
1 VS. 3 30.7903 0.0000
2 VS. 3 9.8825 0.0017
TREND 34.3268 0.0000
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 1 DOSE= ( 0.0) VEHICLE
MEDIAN BIRTH DATE: 12/01/81 600259 M1 05VM MALE MICE C55436
START OF STUDY: 01/26/82
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
NONE...
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
36:001 36:002 36:003 36:004 36:005 37:006 37:007 37:008 37:009 37:010 37:011 37:012 37:013 37:014
37:015 37:016 37:017 37:018 37:019 37:020 38:021 38:022 38:023 38:024 38:025 38:026 38:027 38:028
38:029 38:030 38:031 38:032 38:033 38:034 38:035 39:036 39:037 39:038 39:039 39:040 39:041 39:042
39:043 39:044 39:045 39:046 39:047 39:048 39:049 39:050
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 0
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 50
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 2 DOSE= ( 9500.0) LOW DOSE
MEDIAN BIRTH DATE: 12/01/81 600259 M1 05LM MALE MICE C55436
START OF STUDY: 01/26/82
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
36:042
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
36:001 36:002 36:003 36:004 36:005 36:006 36:007 36:008 36:009 36:010 37:011 37:012 37:013 37:014
37:015 37:016 37:017 37:018 37:019 37:020 37:021 37:022 37:023 37:024 37:025 38:026 38:027 38:028
38:029 38:030 38:031 38:032 38:033 38:034 38:035 38:036 38:037 38:038 38:039 38:040 39:041 39:043
39:044 39:045 39:046 39:047 39:048 39:049 39:050
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 1
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 49
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 3 DOSE= ( 40000.0) HIGH DOSE
MEDIAN BIRTH DATE: 12/01/81 600259 M1 05HM MALE MICE C55436
START OF STUDY: 01/26/82
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
NONE...
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
36:001 36:002 36:003 36:004 36:005 36:006 36:007 36:008 36:009 36:010 37:011 37:012 37:013 37:014
37:015 37:016 37:017 37:018 37:019 37:020 37:021 37:022 37:023 37:024 37:025 38:026 38:027 38:028
38:029 38:030 38:031 38:032 38:033 38:034 38:035 38:036 38:037 38:038 38:039 38:040 39:041 39:042
39:043 39:044 39:045 39:046 39:047 39:048 39:049 39:050
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 0
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 50
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 1 600259 M1 05VM MALE MICE C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 39)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
39 1.000 0.000 39 0.100 0.042 5
39 0.100 0.042 5 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 2 600259 M1 05LM MALE MICE C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 39)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
36 0.980 0.020 36 0.980 0.020 49
39 0.100 0.042 5 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 3 600259 M1 05HM MALE MICE C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 39)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
39 1.000 0.000 39 0.100 0.042 5
39 0.100 0.042 5 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 GRAPH 3 600259 MALE MICE C55436 RUN DATE 02/07/96
0 5 10 15 20 25 30 35 40 45 50
+ + + + + + + + + + +
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1.0+*******************************************************************************
+ 2222222
+
+
+
.9+
P +
R +
O +
B +
A .8+
B +
I +
L +
I +
T .7+
Y +
+
O +
F +
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S +
U +
R +
V +
I .5+
V +
A +
L +
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.4+
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K .3+
A +
P +
L +
A +
N .2+
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I +
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R +
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+ + + + + + + + + + +
0 5 10 15 20 25 30 35 40 45 50
WEEKS ON STUDY
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
600259 MALE MICE C55436
STATISTICAL ANALYSIS OF SURVIVAL DATA
MEAN
SURVIVAL STANDARD STANDARD
GROUP ANIMALS IN WEEKS DEVIATION ERROR
1 50 37.8 1.03 0.146
2 50 37.6 1.00 0.142
3 50 37.6 1.01 0.142
LIFE TABLE ANALYSIS
GROUP CHI-SQUARE P-VALUE
1 VS. 2 0.0000 1.0000
1 VS. 3 ALL OBSERVATIONS CENSORED
2 VS. 3 0.0000 1.0000
TREND 0.2338 1.3712
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 1 DOSE= ( 0.0) VEHICLE
MEDIAN BIRTH DATE: 12/01/81 600259 M1 05VF FEMALE MICE C55436
START OF STUDY: 01/26/82
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
NONE...
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
40:001 40:002 40:003 40:004 40:005 40:006 40:007 40:008 40:009 40:010 40:011 40:012 40:013 40:014
40:015 40:016 40:017 40:018 40:019 40:020 41:021 41:022 41:023 41:024 41:025 41:026 41:027 41:028
41:029 41:030 41:031 41:032 41:033 41:034 41:035 41:036 41:037 41:038 41:039 41:040 42:041 42:042
42:043 42:044 42:045 42:046 42:047 42:048 42:049 42:050
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 0
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 50
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 2 DOSE= ( 7100.0) LOW DOSE
MEDIAN BIRTH DATE: 12/01/81 600259 M1 05LF FEMALE MICE C55436
START OF STUDY: 01/26/82
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
3:015 20:034
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
39:001 39:002 39:003 39:004 39:005 40:006 40:007 40:008 40:009 40:010 40:011 40:012 40:013 40:014
40:016 40:017 40:018 40:019 40:020 41:021 41:022 41:023 41:024 41:025 41:026 41:027 41:028 41:029
41:030 41:031 41:032 41:033 41:035 41:036 41:037 41:038 41:039 41:040 42:041 42:042 42:043 42:044
42:045 42:046 42:047 42:048 42:049 42:050
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 2
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 48
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 3 DOSE= ( 31000.0) HIGH DOSE
MEDIAN BIRTH DATE: 12/01/81 600259 M1 05HF FEMALE MICE C55436
START OF STUDY: 01/26/82
NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)
NONE...
ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)
NONE...
SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)
39:001 39:002 39:003 39:004 39:005 40:006 40:007 40:008 40:009 40:010 40:011 40:012 40:013 40:014
40:015 40:016 40:017 40:018 40:019 40:020 41:021 41:022 41:023 41:024 41:025 41:026 41:027 41:028
41:029 41:030 41:031 41:032 41:033 41:034 41:035 41:036 41:037 41:038 41:039 41:040 42:041 42:042
42:043 42:044 42:045 42:046 42:047 42:048 42:049 42:050
DISPOSITION ANIMALS
NATURAL DEATH OR MORIBUND SACRIFICE: 0
ACCIDENTAL DEATH OR MISSING: 0
SCHEDULED OR TERMINAL SACRIFICE: 50
TOTAL: 50
NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
AS TERMINAL SACRIFICES
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 1 600259 M1 05VF FEMALE MICE C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 42)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
42 1.000 0.000 41 0.200 0.057 10
42 0.200 0.057 10 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 2 600259 M1 05LF FEMALE MICE C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 42)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
3 0.980 0.020 3 0.980 0.020 49
20 0.960 0.028 20 0.960 0.028 48
42 0.200 0.057 10 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
GROUP 3 600259 M1 05HF FEMALE MICE C55436
* KAPLAN-MEIER SURVIVAL CURVE STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS ) (INCLUDES ALL OBS. < END OF STUDY = 42)
( S(T) = OBSERVED PROPORTION OF SURVIVORS )
WEEK P(T) STANDARD WEEK S(T) STANDARD NUMBER
ERROR OF P(T) ERROR OF S(T) SURVIVING
42 1.000 0.000 41 0.200 0.057 10
42 0.200 0.057 10 FINAL SURVIVORSHIP
* THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88 GRAPH 4 600259 FEMALE MICE C55436 RUN DATE 02/07/96
0 5 10 15 20 25 30 35 40 45 50
+ + + + + + + + + + +
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1.0+*************************************************************************************
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T .7+
Y +
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S +
U +
R +
V +
I .5+
V +
A +
L +
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.4+
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K .3+
A +
P +
L +
A +
N .2+
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M +
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E .1+
R +
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-----------------------------------------------------------------------------------------------------
+ + + + + + + + + + +
0 5 10 15 20 25 30 35 40 45 50
WEEKS ON STUDY
VERSION DATE 10/28/88 KAPLAN-MEIER ANALYSIS RUN DATE 02/07/96
600259 FEMALE MICE C55436
STATISTICAL ANALYSIS OF SURVIVAL DATA
MEAN
SURVIVAL STANDARD STANDARD
GROUP ANIMALS IN WEEKS DEVIATION ERROR
1 50 40.8 0.74 0.105
2 50 39.6 6.11 0.865
3 50 40.7 0.84 0.118
LIFE TABLE ANALYSIS
GROUP CHI-SQUARE P-VALUE
1 VS. 2 0.5102 0.4751
1 VS. 3 ALL OBSERVATIONS CENSORED
2 VS. 3 0.5102 0.4751
TREND 0.0014 1.0303
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