National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2369

NTP Study C55436 Pathology Tables















                                            STATISTICAL ANALYSIS OF SURVIVAL DATA

                                            2,3-DIBROMO-1-PROPANOL BY PAINT                                         

                                            CONTRACT NUMBER:      600259

                                            CHEMICAL NUMBER(S):   C55436              

                                            SPECIES:              RATS    MICE            




                                                 KAPLAN-MEIER ANALYSIS   
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  1   DOSE= (      0.0)  VEHICLE                 

 MEDIAN BIRTH DATE: 10/19/81                       600259 R1 05VM MALE RATS       C55436                             
 START OF STUDY:    12/15/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

    NONE...

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   48:011   48:012   48:013   48:014   48:015   49:001   49:002   49:003   49:004   49:005   49:021   49:022   49:023   49:024
  49:025   49:036   49:037   49:038   49:039   49:040   50:031   50:032   50:033   50:034   50:035   50:041   50:042   50:043
  50:044   50:045   50:046   50:047   50:048   50:049   50:050   51:006   51:007   51:008   51:009   51:010   51:016   51:017
  51:018   51:019   51:020   51:026   51:027   51:028   51:029   51:030



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               0

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  50

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  2   DOSE= (  97000.0)  LOW DOSE                

 MEDIAN BIRTH DATE: 10/19/81                       600259 R1 05LM MALE RATS       C55436                             
 START OF STUDY:    12/15/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   41:017   41:021   42:010   44:030   45:006   46:047   47:046   48:020   50:009 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   46:031   48:011   48:012   48:013   48:014   48:015   48:036   48:037   48:038   48:039   48:040   49:026   49:027   49:028
  49:029   49:041   49:042   49:043   49:044   49:045   50:001   50:002   50:003   50:004   50:005   50:007   50:008   50:022
  50:023   50:024   50:025   51:016   51:018   51:019   51:032   51:033   51:034   51:035   51:048   51:049   51:050



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               9

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  41

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  3   DOSE= ( 192000.0)  HIGH DOSE               

 MEDIAN BIRTH DATE: 10/19/81                       600259 R1 05HM MALE RATS       C55436                             
 START OF STUDY:    12/15/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   23:022   25:011   31:012   34:020   35:006   35:032   35:049   36:039   37:023   38:038   38:043   39:024   41:034   41:035 
 42:004   42:026   42:045   43:005   43:029   43:031   44:001   44:013   44:018   45:044   46:002   46:027   46:041   46:046 
 46:048   47:009   47:040   47:042   48:019   50:030 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   42:021   48:003   48:007   48:008   48:010   49:014   49:015   49:016   49:017   49:050   50:025   50:028   50:033   51:036
  51:037   51:047



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              34

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  16

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  1      600259 R1 05VM MALE RATS       C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    51)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        51      1.000      0.000                          50   0.300      0.065             15
                                                          51   0.300      0.065             15   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  2      600259 R1 05LM MALE RATS       C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    51)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        41      0.960      0.028                          41   0.960      0.028             48
        42      0.940      0.034                          42   0.940      0.034             47
        44      0.920      0.038                          44   0.920      0.038             46
        45      0.900      0.042                          45   0.900      0.042             45
        46      0.880      0.046                          46   0.880      0.046             44
        47      0.860      0.049                          47   0.840      0.052             42
        48      0.839      0.052                          48   0.820      0.054             41
        50      0.801      0.062                          50   0.420      0.070             21
                                                          51   0.140      0.049              7   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  3      600259 R1 05HM MALE RATS       C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    51)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        23      0.980      0.020                          23   0.980      0.020             49
        25      0.960      0.028                          25   0.960      0.028             48
        31      0.940      0.034                          31   0.940      0.034             47
        34      0.920      0.038                          34   0.920      0.038             46
        35      0.860      0.049                          35   0.860      0.049             43
        36      0.840      0.052                          36   0.840      0.052             42
        37      0.820      0.054                          37   0.820      0.054             41
        38      0.780      0.059                          38   0.780      0.059             39
        39      0.760      0.060                          39   0.760      0.060             38
        41      0.720      0.063                          41   0.720      0.063             36
        42      0.660      0.067                          42   0.660      0.067             33
        43      0.598      0.070                          43   0.580      0.070             29
        44      0.536      0.071                          44   0.520      0.071             26
        45      0.516      0.071                          45   0.500      0.071             25
        46      0.413      0.070                          46   0.400      0.069             20
        47      0.351      0.068                          47   0.340      0.067             17
        48      0.330      0.067                          48   0.320      0.066             16
        50      0.283      0.072                          50   0.120      0.046              6
                                                          51   0.020      0.020              1   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88        GRAPH   1     600259     MALE RATS           C55436                                   RUN DATE 02/07/96

        0        10        20        30        40        50        60        70        80        90       100
        +         +         +         +         +         +         +         +         +         +         +
        -----------------------------------------------------------------------------------------------------
    1.0+******************************************1111111111                                                    
       +                       333               2                                                              
       +                         3333333         22                                                             
       +                               3333       222                                                           
       +                                  33        22                                                          
     .9+                                   3         22                                                         
  P    +                                   3          22                                                        
  R    +                                   33          22                                                       
  O    +                                    33          222                                                     
  B    +                                     33           2                                                     
  A  .8+                                      3           22                                                    
  B    +                                      33                                                                
  I    +                                       333                                                              
  L    +                                         3                                                              
  I    +                                         33                                                             
  T  .7+                                          3                                                             
  Y    +                                          3                                                             
       +                                          33                                                            
  O    +                                           3                                                            
  F    +                                           3                                                            
     .6+                                           33                                                           
  S    +                                            3                                                           
  U    +                                            3                                                           
  R    +                                            33                                                          
  V    +                                             33                                                         
  I  .5+                                              3                                                         
  V    +                                              3                                                         
  A    +                                              3                                                         
  L    +                                              3                                                         
       +                                              33                                                        
     .4+                                               3                                                        
       +                                               3                                                        
       +                                               33                                                       
       +                                                333                                                     
       +                                                  3                                                     
  K  .3+                                                  3                                                     
  A    +                                                  33                                                    
  P    +                                                                                                        
  L    +                                                                                                        
  A    +                                                                                                        
  N  .2+                                                                                                        
       +                                                                                                        
  M    +                                                                                                        
  E    +                                                                                                        
  I    +                                                                                                        
  E  .1+                                                                                                        
  R    +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
     .0+                                                                                                        
        -----------------------------------------------------------------------------------------------------
        +         +         +         +         +         +         +         +         +         +         +
        0        10        20        30        40        50        60        70        80        90       100
                                                       WEEKS ON STUDY  
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                               600259     MALE RATS           C55436                                   

                                              STATISTICAL ANALYSIS OF SURVIVAL DATA

                                                            MEAN
                                                          SURVIVAL         STANDARD         STANDARD
                               GROUP       ANIMALS        IN WEEKS        DEVIATION          ERROR

                                 1           50              49.9             1.09            0.154

                                 2           50              48.7             2.47            0.350

                                 3           50              43.5             6.52            0.922

                                                         LIFE TABLE ANALYSIS

                                              GROUP          CHI-SQUARE      P-VALUE

                                              1 VS.  2        8.0117         0.0046

                                              1 VS.  3       52.2986         0.0000

                                              2 VS.  3       27.6928         0.0000

                                              TREND          62.0152         0.0000
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  1   DOSE= (      0.0)  VEHICLE                 

 MEDIAN BIRTH DATE: 10/19/81                       600259 R1 05VF FEMALE RATS     C55436                             
 START OF STUDY:    12/15/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   25:049   38:026 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   52:001   52:002   52:003   52:004   52:005   52:021   52:022   52:023   52:024   52:025   52:027   52:028   52:029   52:030
  52:031   52:032   52:033   52:034   52:035   53:011   53:012   53:013   53:014   53:015   54:041   54:042   54:043   54:044
  54:045   54:046   54:047   54:048   54:050   55:006   55:007   55:008   55:009   55:010   55:016   55:017   55:018   55:019
  55:020   55:036   55:037   55:038   55:039   55:040



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               2

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  48

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  2   DOSE= (  78000.0)  LOW DOSE                

 MEDIAN BIRTH DATE: 10/19/81                       600259 R1 05LF FEMALE RATS     C55436                             
 START OF STUDY:    12/15/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   31:025   32:042   39:034   42:029   45:002   46:016   47:035   50:013   51:001   51:017   51:019   51:032   54:033 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   52:003   52:004   52:005   52:006   52:007   52:008   52:009   52:010   52:021   52:022   52:023   52:024   52:046   52:047
  52:048   52:049   52:050   53:018   53:020   54:026   54:027   54:028   54:030   54:036   54:037   54:038   54:039   54:040
  55:011   55:012   55:014   55:015   55:031   55:041   55:043   55:044   55:045



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              13

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  37

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  3   DOSE= ( 157000.0)  HIGH DOSE               

 MEDIAN BIRTH DATE: 10/19/81                       600259 R1 05HF FEMALE RATS     C55436                             
 START OF STUDY:    12/15/81

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   31:014   34:022   36:019   38:028   38:044   41:010   41:045   42:020   43:004   43:027   44:016   45:048   46:040   48:018 
 49:030   49:043   50:011   50:012   50:025   50:034   50:035   50:039   50:047   50:050   51:006   52:002   52:024   52:046 
 53:001 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   49:036   52:015   53:007   53:008   53:009   53:021   53:023   53:026   53:029   53:031   53:032   53:033   53:037   53:038
  53:041   53:042   54:003   54:005   54:017   55:013   55:049



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:              29

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  21

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  1      600259 R1 05VF FEMALE RATS     C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    55)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        25      0.980      0.020                          25   0.980      0.020             49
        38      0.960      0.028                          38   0.960      0.028             48
                                                          55   0.000      0.000              0   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  2      600259 R1 05LF FEMALE RATS     C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    55)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        31      0.980      0.020                          31   0.980      0.020             49
        32      0.960      0.028                          32   0.960      0.028             48
        39      0.940      0.034                          39   0.940      0.034             47
        42      0.920      0.038                          42   0.920      0.038             46
        45      0.900      0.042                          45   0.900      0.042             45
        46      0.880      0.046                          46   0.880      0.046             44
        47      0.860      0.049                          47   0.860      0.049             43
        50      0.840      0.052                          50   0.840      0.052             42
        51      0.760      0.060                          51   0.760      0.060             38
        54      0.720      0.069                          54   0.360      0.068             18
                                                          55   0.000      0.000              0   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  3      600259 R1 05HF FEMALE RATS     C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    55)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        31      0.980      0.020                          31   0.980      0.020             49
        34      0.960      0.028                          34   0.960      0.028             48
        36      0.940      0.034                          36   0.940      0.034             47
        38      0.900      0.042                          38   0.900      0.042             45
        41      0.860      0.049                          41   0.860      0.049             43
        42      0.840      0.052                          42   0.840      0.052             42
        43      0.800      0.057                          43   0.800      0.057             40
        44      0.780      0.059                          44   0.780      0.059             39
        45      0.760      0.060                          45   0.760      0.060             38
        46      0.740      0.062                          46   0.740      0.062             37
        48      0.720      0.063                          48   0.720      0.063             36
        49      0.680      0.066                          49   0.680      0.066             34
        50      0.515      0.071                          50   0.500      0.071             25
        51      0.495      0.071                          51   0.480      0.071             24
        52      0.433      0.071                          52   0.420      0.070             21
        53      0.411      0.070                          53   0.380      0.069             19
                                                          55   0.000      0.000              0   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88        GRAPH   2     600259     FEMALE RATS         C55436                                   RUN DATE 02/07/96

        0        10        20        30        40        50        60        70        80        90       100
        +         +         +         +         +         +         +         +         +         +         +
        -----------------------------------------------------------------------------------------------------
    1.0+********************************                                                                        
       +                         111111****1111                                                                 
       +                                22***2**1111111111111111                                                
       +                                    3332222                                                             
       +                                      3   2222                                                          
     .9+                                      3333   22                                                         
  P    +                                         3    22                                                        
  R    +                                         33    2222                                                     
  O    +                                          33      22                                                    
  B    +                                           3       2                                                    
  A  .8+                                           33      2                                                    
  B    +                                            33     2                                                    
  I    +                                             33    2222                                                 
  L    +                                              333     2                                                 
  I    +                                                33    22                                                
  T  .7+                                                 3                                                      
  Y    +                                                 33                                                     
       +                                                  3                                                     
  O    +                                                  3                                                     
  F    +                                                  3                                                     
     .6+                                                  3                                                     
  S    +                                                  3                                                     
  U    +                                                  3                                                     
  R    +                                                  3                                                     
  V    +                                                  33                                                    
  I  .5+                                                   33                                                   
  V    +                                                    3                                                   
  A    +                                                    3                                                   
  L    +                                                    33                                                  
       +                                                     333                                                
     .4+                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
  K  .3+                                                                                                        
  A    +                                                                                                        
  P    +                                                                                                        
  L    +                                                                                                        
  A    +                                                                                                        
  N  .2+                                                                                                        
       +                                                                                                        
  M    +                                                                                                        
  E    +                                                                                                        
  I    +                                                                                                        
  E  .1+                                                                                                        
  R    +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
     .0+                                                                                                        
        -----------------------------------------------------------------------------------------------------
        +         +         +         +         +         +         +         +         +         +         +
        0        10        20        30        40        50        60        70        80        90       100
                                                       WEEKS ON STUDY  
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                               600259     FEMALE RATS         C55436                                   

                                              STATISTICAL ANALYSIS OF SURVIVAL DATA

                                                            MEAN
                                                          SURVIVAL         STANDARD         STANDARD
                               GROUP       ANIMALS        IN WEEKS        DEVIATION          ERROR

                                 1           50              52.7             4.70            0.665

                                 2           50              51.3             5.23            0.739

                                 3           50              49.0             5.87            0.830

                                                         LIFE TABLE ANALYSIS

                                              GROUP          CHI-SQUARE      P-VALUE

                                              1 VS.  2        7.5002         0.0062

                                              1 VS.  3       30.7903         0.0000

                                              2 VS.  3        9.8825         0.0017

                                              TREND          34.3268         0.0000
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  1   DOSE= (      0.0)  VEHICLE                 

 MEDIAN BIRTH DATE: 12/01/81                       600259 M1 05VM MALE MICE       C55436                             
 START OF STUDY:    01/26/82

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

    NONE...

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   36:001   36:002   36:003   36:004   36:005   37:006   37:007   37:008   37:009   37:010   37:011   37:012   37:013   37:014
  37:015   37:016   37:017   37:018   37:019   37:020   38:021   38:022   38:023   38:024   38:025   38:026   38:027   38:028
  38:029   38:030   38:031   38:032   38:033   38:034   38:035   39:036   39:037   39:038   39:039   39:040   39:041   39:042
  39:043   39:044   39:045   39:046   39:047   39:048   39:049   39:050



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               0

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  50

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  2   DOSE= (   9500.0)  LOW DOSE                

 MEDIAN BIRTH DATE: 12/01/81                       600259 M1 05LM MALE MICE       C55436                             
 START OF STUDY:    01/26/82

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

   36:042 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   36:001   36:002   36:003   36:004   36:005   36:006   36:007   36:008   36:009   36:010   37:011   37:012   37:013   37:014
  37:015   37:016   37:017   37:018   37:019   37:020   37:021   37:022   37:023   37:024   37:025   38:026   38:027   38:028
  38:029   38:030   38:031   38:032   38:033   38:034   38:035   38:036   38:037   38:038   38:039   38:040   39:041   39:043
  39:044   39:045   39:046   39:047   39:048   39:049   39:050



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               1

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  49

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  3   DOSE= (  40000.0)  HIGH DOSE               

 MEDIAN BIRTH DATE: 12/01/81                       600259 M1 05HM MALE MICE       C55436                             
 START OF STUDY:    01/26/82

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

    NONE...

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   36:001   36:002   36:003   36:004   36:005   36:006   36:007   36:008   36:009   36:010   37:011   37:012   37:013   37:014
  37:015   37:016   37:017   37:018   37:019   37:020   37:021   37:022   37:023   37:024   37:025   38:026   38:027   38:028
  38:029   38:030   38:031   38:032   38:033   38:034   38:035   38:036   38:037   38:038   38:039   38:040   39:041   39:042
  39:043   39:044   39:045   39:046   39:047   39:048   39:049   39:050



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               0

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  50

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  1      600259 M1 05VM MALE MICE       C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    39)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        39      1.000      0.000                          39   0.100      0.042              5
                                                          39   0.100      0.042              5   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  2      600259 M1 05LM MALE MICE       C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    39)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        36      0.980      0.020                          36   0.980      0.020             49
                                                          39   0.100      0.042              5   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  3      600259 M1 05HM MALE MICE       C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    39)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        39      1.000      0.000                          39   0.100      0.042              5
                                                          39   0.100      0.042              5   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88        GRAPH   3     600259     MALE MICE           C55436                                   RUN DATE 02/07/96

        0         5        10        15        20        25        30        35        40        45        50
        +         +         +         +         +         +         +         +         +         +         +
        -----------------------------------------------------------------------------------------------------
    1.0+*******************************************************************************                         
       +                                                                        2222222                         
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
     .9+                                                                                                        
  P    +                                                                                                        
  R    +                                                                                                        
  O    +                                                                                                        
  B    +                                                                                                        
  A  .8+                                                                                                        
  B    +                                                                                                        
  I    +                                                                                                        
  L    +                                                                                                        
  I    +                                                                                                        
  T  .7+                                                                                                        
  Y    +                                                                                                        
       +                                                                                                        
  O    +                                                                                                        
  F    +                                                                                                        
     .6+                                                                                                        
  S    +                                                                                                        
  U    +                                                                                                        
  R    +                                                                                                        
  V    +                                                                                                        
  I  .5+                                                                                                        
  V    +                                                                                                        
  A    +                                                                                                        
  L    +                                                                                                        
       +                                                                                                        
     .4+                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
  K  .3+                                                                                                        
  A    +                                                                                                        
  P    +                                                                                                        
  L    +                                                                                                        
  A    +                                                                                                        
  N  .2+                                                                                                        
       +                                                                                                        
  M    +                                                                                                        
  E    +                                                                                                        
  I    +                                                                                                        
  E  .1+                                                                                                        
  R    +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
     .0+                                                                                                        
        -----------------------------------------------------------------------------------------------------
        +         +         +         +         +         +         +         +         +         +         +
        0         5        10        15        20        25        30        35        40        45        50
                                                       WEEKS ON STUDY  
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                               600259     MALE MICE           C55436                                   

                                              STATISTICAL ANALYSIS OF SURVIVAL DATA

                                                            MEAN
                                                          SURVIVAL         STANDARD         STANDARD
                               GROUP       ANIMALS        IN WEEKS        DEVIATION          ERROR

                                 1           50              37.8             1.03            0.146

                                 2           50              37.6             1.00            0.142

                                 3           50              37.6             1.01            0.142

                                                         LIFE TABLE ANALYSIS

                                              GROUP          CHI-SQUARE      P-VALUE

                                              1 VS.  2        0.0000         1.0000

                                              1 VS.  3      ALL OBSERVATIONS CENSORED    

                                              2 VS.  3        0.0000         1.0000

                                              TREND           0.2338         1.3712
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  1   DOSE= (      0.0)  VEHICLE                 

 MEDIAN BIRTH DATE: 12/01/81                       600259 M1 05VF FEMALE MICE     C55436                             
 START OF STUDY:    01/26/82

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

    NONE...

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   40:001   40:002   40:003   40:004   40:005   40:006   40:007   40:008   40:009   40:010   40:011   40:012   40:013   40:014
  40:015   40:016   40:017   40:018   40:019   40:020   41:021   41:022   41:023   41:024   41:025   41:026   41:027   41:028
  41:029   41:030   41:031   41:032   41:033   41:034   41:035   41:036   41:037   41:038   41:039   41:040   42:041   42:042
  42:043   42:044   42:045   42:046   42:047   42:048   42:049   42:050



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               0

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  50

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  2   DOSE= (   7100.0)  LOW DOSE                

 MEDIAN BIRTH DATE: 12/01/81                       600259 M1 05LF FEMALE MICE     C55436                             
 START OF STUDY:    01/26/82

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

    3:015   20:034 

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   39:001   39:002   39:003   39:004   39:005   40:006   40:007   40:008   40:009   40:010   40:011   40:012   40:013   40:014
  40:016   40:017   40:018   40:019   40:020   41:021   41:022   41:023   41:024   41:025   41:026   41:027   41:028   41:029
  41:030   41:031   41:032   41:033   41:035   41:036   41:037   41:038   41:039   41:040   42:041   42:042   42:043   42:044
  42:045   42:046   42:047   42:048   42:049   42:050



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               2

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  48

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                                   GROUP  3   DOSE= (  31000.0)  HIGH DOSE               

 MEDIAN BIRTH DATE: 12/01/81                       600259 M1 05HF FEMALE MICE     C55436                             
 START OF STUDY:    01/26/82

 NATURAL DEATH OR MORIBUND SACRIFICE (WEEKS:ANIMAL NUMBER)

    NONE...

 ACCIDENTAL DEATH OR MISSING (WEEKS:ANIMAL NUMBER)

    NONE...

 SCHEDULED OR TERMINAL SACRIFICE (WEEKS:ANIMAL NUMBER)

   39:001   39:002   39:003   39:004   39:005   40:006   40:007   40:008   40:009   40:010   40:011   40:012   40:013   40:014
  40:015   40:016   40:017   40:018   40:019   40:020   41:021   41:022   41:023   41:024   41:025   41:026   41:027   41:028
  41:029   41:030   41:031   41:032   41:033   41:034   41:035   41:036   41:037   41:038   41:039   41:040   42:041   42:042
  42:043   42:044   42:045   42:046   42:047   42:048   42:049   42:050



                                                  DISPOSITION                         ANIMALS

                                       NATURAL DEATH OR MORIBUND SACRIFICE:               0

                                       ACCIDENTAL DEATH OR MISSING:                       0

                                       SCHEDULED OR TERMINAL SACRIFICE:                  50

                                       TOTAL:                                            50



 NOTE: ANIMALS THAT DIED NATURALLY OR WERE MORIBUND SACRIFICES AFTER THE START OF THE TERMINAL SACRIFICE PERIOD ARE CLASSIFIED
       AS TERMINAL SACRIFICES
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  1      600259 M1 05VF FEMALE MICE     C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    42)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        42      1.000      0.000                          41   0.200      0.057             10
                                                          42   0.200      0.057             10   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  2      600259 M1 05LF FEMALE MICE     C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    42)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
         3      0.980      0.020                           3   0.980      0.020             49
        20      0.960      0.028                          20   0.960      0.028             48
                                                          42   0.200      0.057             10   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                               GROUP  3      600259 M1 05HF FEMALE MICE     C55436                             

     * KAPLAN-MEIER SURVIVAL CURVE                            STANDARD SURVIVAL CURVE
( P(T) = ADJUSTED PROPORTION OF SURVIVORS )              (INCLUDES ALL OBS. < END OF STUDY =    42)
                                                         ( S(T) = OBSERVED PROPORTION OF SURVIVORS )

      WEEK       P(T)     STANDARD                      WEEK    S(T)     STANDARD        NUMBER
                        ERROR OF P(T)                                  ERROR OF S(T)    SURVIVING
        42      1.000      0.000                          41   0.200      0.057             10
                                                          42   0.200      0.057             10   FINAL SURVIVORSHIP

 * THE KAPLAN-MEIER SURVIVAL CURVE ADJUSTS FOR ACCIDENTAL DEATH AND MISSING ANIMALS
VERSION DATE 10/28/88        GRAPH   4     600259     FEMALE MICE         C55436                                   RUN DATE 02/07/96

        0         5        10        15        20        25        30        35        40        45        50
        +         +         +         +         +         +         +         +         +         +         +
        -----------------------------------------------------------------------------------------------------
    1.0+*************************************************************************************                   
       +      22222222222222222222222222222222222                                                               
       +                                        222222222222222222222222222222222222222222222                   
       +                                                                                                        
       +                                                                                                        
     .9+                                                                                                        
  P    +                                                                                                        
  R    +                                                                                                        
  O    +                                                                                                        
  B    +                                                                                                        
  A  .8+                                                                                                        
  B    +                                                                                                        
  I    +                                                                                                        
  L    +                                                                                                        
  I    +                                                                                                        
  T  .7+                                                                                                        
  Y    +                                                                                                        
       +                                                                                                        
  O    +                                                                                                        
  F    +                                                                                                        
     .6+                                                                                                        
  S    +                                                                                                        
  U    +                                                                                                        
  R    +                                                                                                        
  V    +                                                                                                        
  I  .5+                                                                                                        
  V    +                                                                                                        
  A    +                                                                                                        
  L    +                                                                                                        
       +                                                                                                        
     .4+                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
  K  .3+                                                                                                        
  A    +                                                                                                        
  P    +                                                                                                        
  L    +                                                                                                        
  A    +                                                                                                        
  N  .2+                                                                                                        
       +                                                                                                        
  M    +                                                                                                        
  E    +                                                                                                        
  I    +                                                                                                        
  E  .1+                                                                                                        
  R    +                                                                                                        
       +                                                                                                        
       +                                                                                                        
       +                                                                                                        
     .0+                                                                                                        
        -----------------------------------------------------------------------------------------------------
        +         +         +         +         +         +         +         +         +         +         +
        0         5        10        15        20        25        30        35        40        45        50
                                                       WEEKS ON STUDY  
VERSION DATE 10/28/88                                   KAPLAN-MEIER ANALYSIS                                      RUN DATE 02/07/96

                                               600259     FEMALE MICE         C55436                                   

                                              STATISTICAL ANALYSIS OF SURVIVAL DATA

                                                            MEAN
                                                          SURVIVAL         STANDARD         STANDARD
                               GROUP       ANIMALS        IN WEEKS        DEVIATION          ERROR

                                 1           50              40.8             0.74            0.105

                                 2           50              39.6             6.11            0.865

                                 3           50              40.7             0.84            0.118

                                                         LIFE TABLE ANALYSIS

                                              GROUP          CHI-SQUARE      P-VALUE

                                              1 VS.  2        0.5102         0.4751

                                              1 VS.  3      ALL OBSERVATIONS CENSORED    

                                              2 VS.  3        0.5102         0.4751

                                              TREND           0.0014         1.0303

--multipart-boundary
Content-type: text/plain
Range: bytes 69692-69692/69692


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.