National Toxicology Program

National Toxicology Program
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TDMS Study 97013-08 Pathology Tables

NTP  EXP/TEST: 97013-08                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/11/04
ROUTE: GAVAGE                                                                                                     TIME: 08:07:47

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013G

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  75-27-4

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-08                 WATER DISINFECTION MODEL (BROMODICHLOROMETHANE)                           PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 06/11/04
ROUTE: GAVAGE                                               EISRPT03                                              TIME: 08:07:47
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 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: FEMALE      WEEK ON DOSE: 26     FIRST DOSE: 09/15/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     20.5    1.0        11     27.2    1.3                     11      6.7    1.2

 TPA                15     18.7    0.9         0      0.0    0.0                      0      0.0    0.0

 25 MG/KG           15     20.6    1.1        14     30.2    4.8       111.0         14      9.5    4.1

 50 MG/KG           15     20.3    0.9        13     28.7    3.6       105.5         13      8.5    3.1

 100     MG/KG      15     20.1    1.0        13     28.6    4.1       105.1         13      8.5    3.8




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 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: MALE        WEEK ON DOSE: 26     FIRST DOSE: 09/15/99
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     24.3    1.1        13     35.2    5.4                     13     11.0    5.1

 TPA                15     21.3    1.2         2     31.8    3.0        90.3          2     10.2    0.0

 25 MG/KG           15     24.1    1.4        14     35.8    3.2       101.7         14     11.7    3.0

 50 MG/KG           15     23.9    1.4        12     33.8    4.5        96.0         12      9.9    3.8

 100     MG/KG      15     24.0    1.1        14     33.6    2.5        95.4         14      9.6    2.1

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