National Toxicology Program

National Toxicology Program
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TDMS Study 97013-13 Pathology Tables

NTP  EXP/TEST: 97013-13                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 01/27/05
ROUTE: DOSED WATER                                                                                                TIME: 09:04:31

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013C

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  79-43-6

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-13                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 01/27/05
ROUTE: DOSED WATER                                          EISRPT03                                              TIME: 09:04:31
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 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: FEMALE      WEEK ON DOSE: 26     FIRST DOSE: 01/17/00
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/L             15     18.7    0.8        15     30.7    4.8                     15     12.0    4.4

 500 MG/L           15     18.7    0.8         8     32.2    4.9       104.8          8     13.4    5.6

 1000MG/L           15     18.8    0.6        13     28.8    3.8        93.8         13     10.0    3.6

 TPA                15     18.0    1.4         1     29.3    0.0        95.4          1      9.3    0.0

 2000MG/L           15     19.0    1.1        10     28.0    1.8        91.2         10      9.0    1.7




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 SPECIES-STRAIN: TG.AC HEMI-MICE            SEX: MALE        WEEK ON DOSE: 26     FIRST DOSE: 01/17/00
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/L             15     21.2    1.2        14     34.5    2.8                     14     13.1    2.3

 500 MG/L           15     21.9    1.5        13     35.5    6.3       102.8         13     13.6    5.7

 1000MG/L           15     21.7    1.3        11     36.5    4.0       105.7         11     15.0    3.4

 TPA                15     21.3    1.9         0      0.0    0.0                      0      0.0    0.0

 2000MG/L           15     22.0    1.3        14     34.1    2.3        98.8         14     12.2    2.1

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