Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/15992

TDMS Study 97013-13 Pathology Tables

NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03

                                                       FINAL #1/TGAC MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/L
                               Include 002    0 MG/L
                               Include 003    500 MG/L
                               Include 004    500 MG/L
                               Include 005    1000MG/L
                               Include 006    1000MG/L
                               Include 007    2000MG/L
                               Include 008    2000MG/L

























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              4            1            4                                     
    Natural Death                                                   3            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                15            8           13           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 2 [1.0]                                                                      
      Inflammation, Chronic Active                    14 [1.4]     10 [1.2]     12 [1.1]     12 [1.1]                               
      Hepatocyte, Fatty Change                         2 [1.0]      3 [1.7]                                                         
      Hepatocyte, Necrosis                             1 [1.0]      5 [1.4]      1 [2.0]      3 [1.3]                               
      Hepatocyte, Vacuolization Cytoplasmic            6 [1.3]     10 [2.7]     14 [3.1]     14 [3.7]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                                    5 [1.8]      1 [2.0]      1 [2.0]                               
      Epithelium, Hyperplasia                          2 [2.0]      5 [2.0]      2 [2.0]      2 [2.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                2 [1.0]      5 [1.2]      4 [1.5]      7 [1.1]                               
      Subcapsular, Hyperplasia                        10 [1.0]      7 [1.0]      3 [1.0]      9 [1.0]                               
   Pituitary Gland                                    (15)         (14)         (15)         (15)                                   
      Pars Distalis, Cyst                              1 [1.0]                   3 [1.0]      4 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Follicle, Degeneration                           4 [1.0]      4 [1.0]      4 [1.0]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                             1 [2.0]      1 [2.0]      1 [1.0]      2 [3.0]                               
      Inflammation, Chronic Active                                  1 [2.0]                                                         
      Pigmentation, Hemosiderin                                                               1 [2.0]                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Endometrium, Hyperplasia, Cystic                 9 [1.9]      8 [1.3]     10 [1.7]      5 [1.4]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (14)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            3 [2.3]      2 [2.0]      3 [2.3]      2 [2.5]                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                       1 [3.0]      1 [2.0]                                            
      Hematopoietic Cell Proliferation                 1 [2.0]      1 [2.0]                                                         
      Necrosis                                                                                1 [4.0]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 [3.0]      4 [3.5]      3 [3.0]      3 [2.7]                               
      Cyst                                             4 [1.3]      3 [1.3]      4 [1.5]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (4)          (4)          (2)          (8)                                    
      Hyperkeratosis                                                             1 [3.0]                                            
      Epidermis, Hyperplasia                                                     1 [3.0]      4 [2.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic Active                                  1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     1 [2.0]                                1 [3.0]                               
      Necrosis                                                                   1 [2.0]                                            
      Nephropathy                                      5 [1.0]      6 [1.0]      5 [1.0]      7 [1.1]                               
      Cortex, Cyst                                     1 [2.0]                                                                      
      Papilla, Necrosis                                                                       1 [3.0]                               
      Renal Tubule, Dilatation                         3 [2.0]      1 [1.0]      1 [2.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            2            4            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           13           11           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                              3 [1.0]      2 [1.0]      1 [2.0]                               
      Inflammation, Chronic Active                     9 [1.0]     13 [1.2]     12 [1.1]     11 [1.0]                               
      Hepatocyte, Fatty Change                                      3 [1.0]      1 [1.0]                                            
      Hepatocyte, Necrosis                                          1 [1.0]      1 [1.0]                                            
      Hepatocyte, Vacuolization Cytoplasmic            7 [1.0]     13 [1.8]     15 [2.7]     15 [3.7]                               
   Mesentery                                          (1)          (1)          (2)                                                 
      Fat, Fibrosis                                                 1 [2.0]      1 [2.0]                                            
      Fat, Hemorrhage                                  1 [2.0]      1 [2.0]      2 [2.0]                                            
      Fat, Inflammation, Chronic Active                1 [2.0]      1 [2.0]      2 [2.0]                                            
      Fat, Necrosis                                    1 [4.0]      1 [4.0]      2 [4.0]                                            
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                                            1 [2.0]                               
      Epithelium, Hyperkeratosis                                                 1 [2.0]      1 [2.0]                               
      Epithelium, Hyperplasia                          2 [1.0]      4 [2.0]      3 [2.0]      6 [2.0]                               
   Stomach, Glandular                                                                        (1)                                    
      Glands, Ectasia                                                                         1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                1 [1.0]                   1 [1.0]      2 [2.0]                               
      Hypertrophy                                      8 [1.1]      9 [1.7]      8 [1.4]      8 [1.3]                               
      Subcapsular, Hyperplasia                         2 [1.0]                   2 [1.0]                                            
   Pituitary Gland                                    (14)         (15)         (15)         (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                              1 [1.0]      1 [1.0]      1 [1.0]      1 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                             1 [1.0]                                                         
      Follicle, Degeneration                           7 [1.0]      8 [1.0]      5 [1.0]      5 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                     2 [4.0]      2 [4.0]      2 [4.0]      2 [4.0]                               
   Preputial Gland                                                 (2)          (1)                                                 
      Duct, Ectasia                                                 2 [2.5]      1 [4.0]                                            
   Seminal Vesicle                                    (1)                                                                           
      Inflammation, Chronic Active                     1 [1.0]                                                                      
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                             1 [2.0]      1 [2.0]      1 [2.0]      1 [2.0]                               
      Germinal Epithelium, Degeneration                2 [3.5]      2 [2.5]      1 [2.0]      2 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (14)         (15)         (14)                                   
      Hyperplasia, Lymphoid                            1 [2.0]      3 [2.7]      2 [2.0]                                            
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                                           2 [2.0]      1 [2.0]                               
   Thymus                                             (15)         (15)         (14)         (14)                                   
      Atrophy                                          1 [3.0]      3 [3.0]      4 [2.8]                                            
      Cyst                                             1 [1.0]      2 [1.5]      1 [1.0]      2 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (4)          (4)          (4)          (6)                                    
      Inflammation, Chronic Active                                                            1 [2.0]                               
      Epidermis, Hyperplasia                           1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  4 [1.3]      2 [2.5]      1 [1.0]                               
      Alveolar Epithelium, Hyperplasia                                           1 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  1 [4.0]                                                         
      Necrosis                                                      1 [2.0]                                                         
      Nephropathy                                     10 [1.0]      9 [1.0]     12 [1.1]     14 [1.0]                               
      Renal Tubule, Dilatation                         1 [2.0]                                2 [1.5]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------