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TDMS Study 97013-13 Pathology Tables

NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03

                                                       FINAL #1/TGAC MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/L
                               Include 002    0 MG/L
                               Include 003    500 MG/L
                               Include 004    500 MG/L
                               Include 005    1000MG/L
                               Include 006    1000MG/L
                               Include 007    2000MG/L
                               Include 008    2000MG/L

























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              4            1            4                                     
    Natural Death                                                   3            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                15            8           13           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 2 [1.0]                                                                      
      Inflammation, Chronic Active                    14 [1.4]     10 [1.2]     12 [1.1]     12 [1.1]                               
      Hepatocyte, Fatty Change                         2 [1.0]      3 [1.7]                                                         
      Hepatocyte, Necrosis                             1 [1.0]      5 [1.4]      1 [2.0]      3 [1.3]                               
      Hepatocyte, Vacuolization Cytoplasmic            6 [1.3]     10 [2.7]     14 [3.1]     14 [3.7]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                                    5 [1.8]      1 [2.0]      1 [2.0]                               
      Epithelium, Hyperplasia                          2 [2.0]      5 [2.0]      2 [2.0]      2 [2.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                2 [1.0]      5 [1.2]      4 [1.5]      7 [1.1]                               
      Subcapsular, Hyperplasia                        10 [1.0]      7 [1.0]      3 [1.0]      9 [1.0]                               
   Pituitary Gland                                    (15)         (14)         (15)         (15)                                   
      Pars Distalis, Cyst                              1 [1.0]                   3 [1.0]      4 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Follicle, Degeneration                           4 [1.0]      4 [1.0]      4 [1.0]      3 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                             1 [2.0]      1 [2.0]      1 [1.0]      2 [3.0]                               
      Inflammation, Chronic Active                                  1 [2.0]                                                         
      Pigmentation, Hemosiderin                                                               1 [2.0]                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Endometrium, Hyperplasia, Cystic                 9 [1.9]      8 [1.3]     10 [1.7]      5 [1.4]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (14)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            3 [2.3]      2 [2.0]      3 [2.3]      2 [2.5]                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                       1 [3.0]      1 [2.0]                                            
      Hematopoietic Cell Proliferation                 1 [2.0]      1 [2.0]                                                         
      Necrosis                                                                                1 [4.0]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 [3.0]      4 [3.5]      3 [3.0]      3 [2.7]                               
      Cyst                                             4 [1.3]      3 [1.3]      4 [1.5]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (4)          (4)          (2)          (8)                                    
      Hyperkeratosis                                                             1 [3.0]                                            
      Epidermis, Hyperplasia                                                     1 [3.0]      4 [2.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic Active                                  1 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     1 [2.0]                                1 [3.0]                               
      Necrosis                                                                   1 [2.0]                                            
      Nephropathy                                      5 [1.0]      6 [1.0]      5 [1.0]      7 [1.1]                               
      Cortex, Cyst                                     1 [2.0]                                                                      
      Papilla, Necrosis                                                                       1 [3.0]                               
      Renal Tubule, Dilatation                         3 [2.0]      1 [1.0]      1 [2.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            2            4            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           13           11           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                              3 [1.0]      2 [1.0]      1 [2.0]                               
      Inflammation, Chronic Active                     9 [1.0]     13 [1.2]     12 [1.1]     11 [1.0]                               
      Hepatocyte, Fatty Change                                      3 [1.0]      1 [1.0]                                            
      Hepatocyte, Necrosis                                          1 [1.0]      1 [1.0]                                            
      Hepatocyte, Vacuolization Cytoplasmic            7 [1.0]     13 [1.8]     15 [2.7]     15 [3.7]                               
   Mesentery                                          (1)          (1)          (2)                                                 
      Fat, Fibrosis                                                 1 [2.0]      1 [2.0]                                            
      Fat, Hemorrhage                                  1 [2.0]      1 [2.0]      2 [2.0]                                            
      Fat, Inflammation, Chronic Active                1 [2.0]      1 [2.0]      2 [2.0]                                            
      Fat, Necrosis                                    1 [4.0]      1 [4.0]      2 [4.0]                                            
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                                            1 [2.0]                               
      Epithelium, Hyperkeratosis                                                 1 [2.0]      1 [2.0]                               
      Epithelium, Hyperplasia                          2 [1.0]      4 [2.0]      3 [2.0]      6 [2.0]                               
   Stomach, Glandular                                                                        (1)                                    
      Glands, Ectasia                                                                         1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                1 [1.0]                   1 [1.0]      2 [2.0]                               
      Hypertrophy                                      8 [1.1]      9 [1.7]      8 [1.4]      8 [1.3]                               
      Subcapsular, Hyperplasia                         2 [1.0]                   2 [1.0]                                            
   Pituitary Gland                                    (14)         (15)         (15)         (15)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Cyst                              1 [1.0]      1 [1.0]      1 [1.0]      1 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Infiltration Cellular, Lymphocyte                             1 [1.0]                                                         
      Follicle, Degeneration                           7 [1.0]      8 [1.0]      5 [1.0]      5 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                     2 [4.0]      2 [4.0]      2 [4.0]      2 [4.0]                               
   Preputial Gland                                                 (2)          (1)                                                 
      Duct, Ectasia                                                 2 [2.5]      1 [4.0]                                            
   Seminal Vesicle                                    (1)                                                                           
      Inflammation, Chronic Active                     1 [1.0]                                                                      
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                             1 [2.0]      1 [2.0]      1 [2.0]      1 [2.0]                               
      Germinal Epithelium, Degeneration                2 [3.5]      2 [2.5]      1 [2.0]      2 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (14)         (15)         (14)                                   
      Hyperplasia, Lymphoid                            1 [2.0]      3 [2.7]      2 [2.0]                                            
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                                           2 [2.0]      1 [2.0]                               
   Thymus                                             (15)         (15)         (14)         (14)                                   
      Atrophy                                          1 [3.0]      3 [3.0]      4 [2.8]                                            
      Cyst                                             1 [1.0]      2 [1.5]      1 [1.0]      2 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (4)          (4)          (4)          (6)                                    
      Inflammation, Chronic Active                                                            1 [2.0]                               
      Epidermis, Hyperplasia                           1 [2.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-13         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:04:03    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  4 [1.3]      2 [2.5]      1 [1.0]                               
      Alveolar Epithelium, Hyperplasia                                           1 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  1 [4.0]                                                         
      Necrosis                                                      1 [2.0]                                                         
      Nephropathy                                     10 [1.0]      9 [1.0]     12 [1.1]     14 [1.0]                               
      Renal Tubule, Dilatation                         1 [2.0]                                2 [1.5]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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