National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16251

TDMS Study 97013-14 Pathology Tables

NTP Experiment-Test: 97013-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:31:44

                                                          FINAL #1/P53




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:31:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                                                1                                                  
    Moribund Sacrifice                                                                        1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           14           14                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                    15 [1.2]     14 [1.1]     13 [1.2]     14 [1.1]                               
      Hepatocyte, Necrosis                             1 [1.0]                                                                      
      Hepatocyte, Vacuolization Cytoplasmic            3 [1.0]     15 [2.2]     15 [3.1]     15 [3.5]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                                            1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                4 [1.5]      2 [2.0]      1 [1.0]                                            
      Subcapsular, Hyperplasia                        14 [1.0]     14 [1.0]     15 [1.0]     14 [1.1]                               
   Parathyroid Gland                                  (1)                                                                           
      Cyst                                             1 [2.0]                                                                      
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                              1 [1.0]      2 [1.0]      3 [1.0]                                            
      Pars Distalis, Hyperplasia                       1 [1.0]                   3 [1.0]      5 [1.0]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                   1 [2.0]                                                                      
      Infiltration Cellular, Lymphocyte                2 [2.0]      1 [2.0]                                                         
      Follicle, Degeneration                           1 [1.0]      3 [1.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:31:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                                          2 [2.5]      1 [2.0]      1 [2.0]                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                     1 [3.0]                                1 [1.0]                               
      Endometrium, Hyperplasia, Cystic                 8 [1.5]     12 [1.9]     13 [1.6]     13 [1.4]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                      (1)                                                              
      Mediastinal, Hyperplasia, Lymphoid                            1 [3.0]                                                         
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            1 [2.0]                   4 [2.3]      4 [2.5]                               
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                                                                   1 [2.0]                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                                 1 [2.0]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                                                                 1 [3.0]                               
      Cyst                                            10 [1.6]     11 [1.8]     11 [1.6]     12 [1.7]                               
      Ectopic Parathyroid Gland                        2 [1.5]      2 [1.0]      1 [1.0]      2 [1.0]                               
      Thymocyte, Necrosis                                           6 [1.8]      2 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:31:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                       0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  2 [1.5]      3 [1.0]      1 [2.0]                               
      Alveolus, Infiltration Cellular, Histiocyte                   1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Cyst                                                                                    1 [3.0]                               
      Mineralization                                                             4 [1.0]      1 [1.0]                               
      Nephropathy                                      3 [1.0]     11 [1.0]      7 [1.0]      9 [1.0]                               
      Renal Tubule, Dilatation                                                   2 [2.0]      1 [2.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:31:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           15           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 1 [1.0]                                                                      
      Inflammation, Chronic Active                    15 [1.0]     13 [1.0]     15 [1.1]     13 [1.0]                               
      Hepatocyte, Fatty Change                        10 [1.1]      2 [1.0]      1 [1.0]                                            
      Hepatocyte, Necrosis                             1 [1.0]                   1 [1.0]                                            
      Hepatocyte, Vacuolization Cytoplasmic           15 [2.7]     15 [3.4]     15 [3.4]     15 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                1 [1.0]                   1 [2.0]                                            
      Hypertrophy                                      1 [2.0]                   1 [2.0]      2 [1.5]                               
      Subcapsular, Hyperplasia                         4 [1.0]                   3 [1.0]      3 [1.0]                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                              3 [1.0]      2 [1.0]      2 [1.0]      1 [1.0]                               
      Pars Distalis, Hyperplasia                                                 6 [1.0]                                            
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                                                          2 [1.5]                               
      Follicle, Cyst                                                             1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:31:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Granuloma Sperm                                  1 [3.0]                                                                      
      Infiltration Cellular, Lymphocyte                                          3 [1.3]                                            
      Inflammation, Chronic Active                                               1 [1.0]                                            
   Testes                                             (15)         (15)         (15)         (15)                                   
      Mineralization                                   1 [1.0]                   1 [1.0]                                            
      Germinal Epithelium, Degeneration                2 [1.0]      4 [1.0]      3 [1.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                                                      2 [2.0]      1 [2.0]                               
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            1 [2.0]      1 [2.0]                                                         
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Cyst                                             9 [1.4]      9 [1.9]      9 [1.4]      9 [1.3]                               
      Ectopic Parathyroid Gland                                                  1 [1.0]                                            
      Hyperplasia, Lymphoid                                         1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-14         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:31:44    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                         0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Mineralization                                                             1 [1.0]                                            
      Nephropathy                                      8 [1.0]     10 [1.0]     11 [1.0]     12 [1.0]                               
      Renal Tubule, Dilatation                         2 [1.5]      4 [1.8]                   2 [1.5]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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