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TDMS Study 97013-15 Pathology Tables

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                                                                           TIME: 09:17:27

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013D

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  79-43-6

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 2                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 3
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 4                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: FEMALE                               TRT: 31.25   MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 4
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 6                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: FEMALE                               TRT: 125MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 5
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 10                     ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: FEMALE                               TRT: TPA                PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

536         536   71 04/27/00    71 04/27/00   1/12  Papilloma Site Of Application Small 13
                  78 05/04/00    78 05/04/00   1/12  Papilloma Site Of Application Small 20

  REMOVED  **  CID   536 **   REASON - Other
                                 84 05/10/00         Papilloma Site Of Application Small 20


537         537   57 04/13/00    57 04/13/00   1/10  Papilloma Site Of Application Small 19
                  64 04/20/00    64 04/20/00   1/10  Papilloma Site Of Application Small 20

  REMOVED  **  CID   537 **   REASON - Other
                                 68 04/24/00         Papilloma Site Of Application Small 20


538         538   57 04/13/00    57 04/13/00   1/9   Papilloma Site Of Application Small 20

  REMOVED  **  CID   538 **   REASON - MSAC
                                 58 04/14/00         Papilloma Site Of Application Small 20


539         539   57 04/13/00    57 04/13/00   1/10  Papilloma Site Of Application Small 18
                  64 04/20/00    64 04/20/00   1/10  Papilloma Site Of Application Small 20

  REMOVED  **  CID   539 **   REASON - Other
                                 68 04/24/00         Papilloma Site Of Application Small 20


540         540   78 05/04/00    78 05/04/00   1/13  Papilloma Site Of Application Small 10
                  85 05/11/00    85 05/11/00   1/13  Papilloma Site Of Application Small 20
                  71 04/27/00    71 04/27/00   1/13  Papilloma Site Of Application Small 6

  REMOVED  **  CID   540 **   REASON - Other
                                 90 05/16/00         Papilloma Site Of Application Small 20


541         541   71 04/27/00    71 04/27/00   1/11  Papilloma Site Of Application Small 20
                  64 04/20/00    64 04/20/00   1/11  Papilloma Site Of Application Small 9

  REMOVED  **  CID   541 **   REASON - Other
                                 75 05/01/00         Papilloma Site Of Application Small 20


542         542   71 04/27/00    71 04/27/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   542 **   REASON - Other
                                 75 05/01/00         Papilloma Site Of Application Small 20

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 6
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 10                     ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: FEMALE                               TRT: TPA                PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

543         543   64 04/20/00    64 04/20/00   1/10  Papilloma Site Of Application Small 20

  REMOVED  **  CID   543 **   REASON - Other
                                 68 04/24/00         Papilloma Site Of Application Small 20


544         544   64 04/20/00    64 04/20/00   1/15  Papilloma Site Of Application Small 1
                  92 05/18/00    92 05/18/00   1/15  Papilloma Site Of Application Small 16
                  71 04/27/00    71 04/27/00   1/15  Papilloma Site Of Application Small 2
                  99 05/25/00    99 05/25/00   1/15  Papilloma Site Of Application Small 20
                  78 05/04/00    78 05/04/00   1/15  Papilloma Site Of Application Small 3
                  85 05/11/00    85 05/11/00   1/15  Papilloma Site Of Application Small 4

  REMOVED  **  CID   544 **   REASON - Other
                                100 05/26/00         Papilloma Site Of Application Small 20


545         545   71 04/27/00    71 04/27/00   1/13  Papilloma Site Of Application Small 14
                  78 05/04/00    78 05/04/00   1/13  Papilloma Site Of Application Small 18
                  85 05/11/00    85 05/11/00   1/13  Papilloma Site Of Application Small 20
                  64 04/20/00    64 04/20/00   1/13  Papilloma Site Of Application Small 7

  REMOVED  **  CID   545 **   REASON - Other
                                 90 05/16/00         Papilloma Site Of Application Small 20


546         546   92 05/18/00    92 05/18/00   1/15  Papilloma Site Of Application Small 11
                  85 05/11/00    85 05/11/00   1/15  Papilloma Site Of Application Small 13
                  78 05/04/00    78 05/04/00   1/15  Papilloma Site Of Application Small 14
                  99 05/25/00    99 05/25/00   1/15  Papilloma Site Of Application Small 20
                  71 04/27/00    71 04/27/00   1/15  Papilloma Site Of Application Small 8

  REMOVED  **  CID   546 **   REASON - Other
                                100 05/26/00         Papilloma Site Of Application Small 20


547         547   99 05/25/00   106 06/01/00   2/18  Papilloma Site Of Application Small 11
                 113 06/08/00   113 06/08/00   1/18  Papilloma Site Of Application Small 14
                  71 04/27/00    71 04/27/00   1/18  Papilloma Site Of Application Small 2
                 120 06/15/00   120 06/15/00   1/18  Papilloma Site Of Application Small 20
                  78 05/04/00    85 05/11/00   2/18  Papilloma Site Of Application Small 5
                  92 05/18/00    92 05/18/00   1/18  Papilloma Site Of Application Small 8

  REMOVED  **  CID   547 **   REASON - Other
                                124 06/19/00         Papilloma Site Of Application Small 20


548         548   71 04/27/00    71 04/27/00   1/11  Papilloma Site Of Application Small 20

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 7
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 10                     ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: FEMALE                               TRT: TPA                PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------


  REMOVED  **  CID   548 **   REASON - Other
548         548                  75 05/01/00         Papilloma Site Of Application Small 20


549         549   71 04/27/00    71 04/27/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   549 **   REASON - Other
                                 75 05/01/00         Papilloma Site Of Application Small 20


550         550   78 05/04/00    85 05/11/00   2/15  Papilloma Site Of Application Small 13
                  92 05/18/00    92 05/18/00   1/15  Papilloma Site Of Application Small 15
                  99 05/25/00    99 05/25/00   1/15  Papilloma Site Of Application Small 20
                  71 04/27/00    71 04/27/00   1/15  Papilloma Site Of Application Small 8

  REMOVED  **  CID   550 **   REASON - Other
                                100 05/26/00         Papilloma Site Of Application Small 20

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 8
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 8                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: FEMALE                               TRT: 500MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

509         509  176 08/10/00   176 08/10/00   1/26  Papilloma Site Of Application Small 1

  REMOVED  **  CID   509 **   REASON - TSAC
                                183 08/17/00         Papilloma Site Of Application Small 1
                                183 08/17/00         Papilloma Torso/Ventral Small 1


513         513  113 06/08/00   155 07/20/00   7/26  Papilloma Site Of Application Small 1

  REMOVED  **  CID   513 **   REASON - TSAC
                                183 08/17/00         Unremarkable


515         515  106 06/01/00   176 08/10/00  11/26  Papilloma Site Of Application Small 1

  REMOVED  **  CID   515 **   REASON - TSAC
                                183 08/17/00         Mass Head Small 1
                                183 08/17/00         Papilloma Site Of Application Small 1


518         518  148 07/13/00   176 08/10/00   5/26  Papilloma Site Of Application Small 1
                 120 06/15/00   141 07/06/00   4/26  Papilloma Site Of Application Small 2

  REMOVED  **  CID   518 **   REASON - TSAC
                                183 08/17/00         Papilloma Site Of Application Small 1

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 9
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 1                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 10
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 3                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: MALE                                 TRT: 31.25   MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

429         429  120 06/15/00   148 07/13/00   5/26  Papilloma Site Of Application Small 1

  REMOVED  **  CID   429 **   REASON - TSAC
                                182 08/16/00         Unremarkable

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 11
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 5                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: MALE                                 TRT: 125MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 12
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

521         521   78 05/04/00    78 05/04/00   1/14  Papilloma Site Of Application Medium 1
                  85 05/11/00    85 05/11/00   1/14  Papilloma Site Of Application Small 10
                  92 05/18/00    92 05/18/00   1/14  Papilloma Site Of Application Small 20
                  71 04/27/00    71 04/27/00   1/14  Papilloma Site Of Application Small 6
                  78 05/04/00    78 05/04/00   1/14  Papilloma Site Of Application Small 7

  REMOVED  **  CID   521 **   REASON - Other
                                 93 05/19/00         Papilloma Site Of Application Small 20


522         522   64 04/20/00    64 04/20/00   1/11  Papilloma Site Of Application Small 18
                  71 04/27/00    71 04/27/00   1/11  Papilloma Site Of Application Small 20
                  57 04/13/00    57 04/13/00   1/11  Papilloma Site Of Application Small 8

  REMOVED  **  CID   522 **   REASON - Other
                                 75 05/01/00         Papilloma Site Of Application Small 20


523         523   57 04/13/00    57 04/13/00   1/10  Papilloma Site Of Application Small 12
                  64 04/20/00    64 04/20/00   1/10  Papilloma Site Of Application Small 20

  REMOVED  **  CID   523 **   REASON - Other
                                 68 04/24/00         Papilloma Site Of Application Small 20


524         524  106 06/01/00   106 06/01/00   1/17  Papilloma Site Of Application Small 10
                  64 04/20/00    71 04/27/00   2/17  Papilloma Site Of Application Small 15
                  85 05/11/00    85 05/11/00   1/17  Papilloma Site Of Application Small 2
                 113 06/08/00   113 06/08/00   1/17  Papilloma Site Of Application Small 20
                  78 05/04/00    78 05/04/00   1/17  Papilloma Site Of Application Small 6
                  99 05/25/00    99 05/25/00   1/17  Papilloma Site Of Application Small 7
                  92 05/18/00    92 05/18/00   1/17  Papilloma Site Of Application Small 8

  REMOVED  **  CID   524 **   REASON - Other
                                117 06/12/00         Papilloma Site Of Application Small 20


525         525   57 04/13/00    57 04/13/00   1/10  Papilloma Site Of Application Small 11
                  64 04/20/00    64 04/20/00   1/10  Papilloma Site Of Application Small 20

  REMOVED  **  CID   525 **   REASON - Other
                                 68 04/24/00         Papilloma Site Of Application Small 20


526         526   71 04/27/00    71 04/27/00   1/11  Papilloma Site Of Application Small 20

  REMOVED  **  CID   526 **   REASON - Other
                                 75 05/01/00         Papilloma Site Of Application Small 20

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 13
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------



527         527   85 05/11/00    85 05/11/00   1/15  Papilloma Site Of Application Small 10
                  92 05/18/00    92 05/18/00   1/15  Papilloma Site Of Application Small 15
                  99 05/25/00    99 05/25/00   1/15  Papilloma Site Of Application Small 20
                  78 05/04/00    78 05/04/00   1/15  Papilloma Site Of Application Small 9

  REMOVED  **  CID   527 **   REASON - Other
                                100 05/26/00         Papilloma Site Of Application Small 20


528         528   85 05/11/00    85 05/11/00   1/14  Papilloma Site Of Application Small 13
                  92 05/18/00    92 05/18/00   1/14  Papilloma Site Of Application Small 20
                  78 05/04/00    78 05/04/00   1/14  Papilloma Site Of Application Medium 3
                  78 05/04/00    78 05/04/00   1/14  Papilloma Site Of Application Small 7
                  71 04/27/00    71 04/27/00   1/14  Papilloma Site Of Application Small 8

  REMOVED  **  CID   528 **   REASON - Other
                                 93 05/19/00         Papilloma Site Of Application Small 20


529         529   71 04/27/00    71 04/27/00   1/13  Papilloma Site Of Application Small 17
                  78 05/04/00    78 05/04/00   1/13  Papilloma Site Of Application Small 18
                  85 05/11/00    85 05/11/00   1/13  Papilloma Site Of Application Small 20

  REMOVED  **  CID   529 **   REASON - Other
                                 90 05/16/00         Papilloma Site Of Application Small 20


530         530   92 05/18/00    92 05/18/00   1/15  Papilloma Site Of Application Small 11
                  99 05/25/00    99 05/25/00   1/15  Papilloma Site Of Application Small 20
                  78 05/04/00    85 05/11/00   2/15  Papilloma Site Of Application Small 6

  REMOVED  **  CID   530 **   REASON - Other
                                100 05/26/00         Papilloma Site Of Application Small 20


531         531   64 04/20/00    64 04/20/00   1/13  Papilloma Site Of Application Small 10
                  71 04/27/00    71 04/27/00   1/13  Papilloma Site Of Application Small 11
                  85 05/11/00    85 05/11/00   1/13  Papilloma Site Of Application Small 20
                  78 05/04/00    78 05/04/00   1/13  Papilloma Site Of Application Small 7
                  78 05/04/00    78 05/04/00   1/13  Papilloma Site Of Application Medium 9

  REMOVED  **  CID   531 **   REASON - Other
                                 90 05/16/00         Papilloma Site Of Application Small 20


533         533   78 05/04/00    85 05/11/00   2/15  Papilloma Site Of Application Small 15

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 14
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 9                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: MALE                                 TRT: TPA                PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

                              - CONTINUATION OF PREVIOUS ANIMAL DATA -
533         533   92 05/18/00    92 05/18/00   1/15  Papilloma Site Of Application Small 16
                  99 05/25/00    99 05/25/00   1/15  Papilloma Site Of Application Small 20
                  71 04/27/00    71 04/27/00   1/15  Papilloma Site Of Application Small 6

  REMOVED  **  CID   533 **   REASON - Other
                                100 05/26/00         Papilloma Site Of Application Small 20


534         534   85 05/11/00    85 05/11/00   1/15  Papilloma Site Of Application Small 14
                  92 05/18/00    92 05/18/00   1/15  Papilloma Site Of Application Small 18
                  99 05/25/00    99 05/25/00   1/15  Papilloma Site Of Application Small 20
                  78 05/04/00    78 05/04/00   1/15  Papilloma Site Of Application Small 6

  REMOVED  **  CID   534 **   REASON - Other
                                100 05/26/00         Papilloma Site Of Application Small 20


535         535   64 04/20/00    64 04/20/00   1/12  Papilloma Site Of Application Small 11
                  71 04/27/00    71 04/27/00   1/12  Papilloma Site Of Application Small 13
                  78 05/04/00    78 05/04/00   1/12  Papilloma Site Of Application Small 20
                  57 04/13/00    57 04/13/00   1/12  Papilloma Site Of Application Small 6

  REMOVED  **  CID   535 **   REASON - Other
                                 84 05/10/00         Papilloma Site Of Application Small 20

NTP  EXP/TEST: 97013-15                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                           PAGE: 15
TEST TYPE: SUBCHRON 26-WEEK      DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 01/27/05
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 09:17:27
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 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 7                      ROOM/AREA:    207         FIRST DOSE: 02/17/00
            SEX: MALE                                 TRT: 500MG/KG           PROCEDURE SET:      1
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                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

451         451  106 06/01/00   120 06/15/00   3/26  Papilloma Site Of Application Small 1

  REMOVED  **  CID   451 **   REASON - TSAC
                                182 08/16/00         Mass Head Small 3


456         456  169 08/03/00   176 08/10/00   2/26  Papilloma Site Of Application Small 1

  REMOVED  **  CID   456 **   REASON - TSAC
                                182 08/16/00         Papilloma Site Of Application Small 1



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