National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16259

TDMS Study 97013-15 Pathology Tables

NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05
Route: SKIN APPLICATION                                                                                           Time: 10:06:53

                                                       FINAL #1 TGAC MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/13/01

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/KG
                               Include 002    0 MG/KG
                               Include 003    31.25   MG/KG
                               Include 004    31.25   MG/KG
                               Include 005    125MG/KG
                               Include 006    125MG/KG
                               Include 007    500MG/KG
                               Include 008    500MG/KG


























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: SKIN APPLICATION                                                                                           Time: 10:06:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4            2            1                                                  
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                11           12           14           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                    11 (73%)     13 (87%)     14 (93%)     11 (73%)                               
      Hepatocyte, Necrosis                             1 (7%)                                 3 (20%)                               
      Hepatocyte, Vacuolization Cytoplasmic            6 (40%)      4 (27%)     14 (93%)     15 (100%)                              
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                       1 (7%)                                                                       
      Epithelium, Hyperplasia                          1 (7%)       1 (7%)       1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                             2 (13%)      7 (47%)      4 (27%)                               
      Subcapsular, Hyperplasia                         5 (33%)      8 (53%)      6 (40%)      9 (60%)                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                              3 (20%)      4 (27%)      3 (20%)      3 (20%)                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                                1 (7%)                                                          
      Follicle, Degeneration                           5 (33%)      4 (27%)      2 (13%)      1 (7%)                                
      Follicular Cell, Hyperplasia                                               1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: SKIN APPLICATION                                                                                           Time: 10:06:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                             3 (20%)      2 (13%)      1 (7%)       1 (7%)                                
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Endometrium, Hyperplasia, Cystic                10 (67%)     12 (80%)     10 (67%)     14 (93%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            3 (20%)      1 (7%)       4 (27%)      2 (13%)                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          3 (20%)      1 (7%)       1 (7%)                                             
      Cyst                                             3 (20%)      8 (53%)      7 (47%)      9 (60%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)                                   
      Hyperkeratosis                                   1 (7%)                    1 (7%)                                             
      Inflammation, Chronic Active                     1 (7%)                                                                       
      Epidermis, Hyperplasia                           3 (20%)      1 (7%)       1 (7%)       2 (13%)                               
      Site of Application - Epidermis,                                                                                              
        Hyperkeratosis                                 8 (53%)      9 (60%)     14 (93%)     14 (93%)                               
      Site of Application - Epidermis, Hyperplasia                  1 (7%)      10 (67%)     13 (87%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (14)                                   
      Inflammation, Chronic Active                     1 (7%)                                 1 (7%)                                
      Thrombosis                                                                              1 (7%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: SKIN APPLICATION                                                                                           Time: 10:06:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                                           1 (7%)       1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Nephropathy                                      3 (20%)      6 (40%)      5 (33%)      5 (33%)                               
      Renal Tubule, Dilatation                         2 (13%)      3 (20%)      3 (20%)      1 (7%)                                
      Renal Tubule, Hyperplasia                                                  1 (7%)                                             
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: SKIN APPLICATION                                                                                           Time: 10:06:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2                                      2                                     
    Natural Death                                                   1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           14           14           12                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 3 (20%)                                                                      
      Inflammation, Chronic Active                     2 (13%)      8 (53%)      4 (27%)      2 (13%)                               
      Pigmentation                                                                            1 (7%)                                
      Hepatocyte, Necrosis                             1 (7%)       2 (13%)                   2 (13%)                               
      Hepatocyte, Vacuolization Cytoplasmic            3 (20%)      4 (27%)     14 (93%)     15 (100%)                              
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                                                              1 (7%)                                
      Epithelium, Hyperplasia                          1 (7%)                                 1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Hypertrophy                                     11 (73%)      7 (47%)      7 (47%)      7 (47%)                               
      Subcapsular, Hyperplasia                         4 (27%)      1 (7%)       2 (13%)                                            
   Parathyroid Gland                                               (1)                                                              
      Cyst                                                          1 (100%)                                                        
   Pituitary Gland                                    (15)         (15)         (14)         (15)                                   
      Pars Distalis, Cyst                                           1 (7%)                    3 (20%)                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Follicle, Degeneration                           3 (20%)      3 (20%)      2 (13%)      1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: SKIN APPLICATION                                                                                           Time: 10:06:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                     2 (13%)      1 (7%)       1 (7%)       1 (7%)                                
      Inflammation, Chronic Active                                                            1 (7%)                                
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                                          1 (7%)       1 (7%)       1 (7%)                                
      Germinal Epithelium, Degeneration                2 (13%)      1 (7%)       1 (7%)       2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (14)                                   
      Hyperplasia, Lymphoid                                         2 (13%)                   1 (7%)                                
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 3 (20%)                                                                      
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 (7%)       1 (7%)                    2 (13%)                               
      Cyst                                             6 (40%)      1 (7%)       4 (27%)      2 (13%)                               
      Thymocyte, Necrosis                                                                     2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)                                   
      Epidermis, Hyperplasia                           2 (13%)      3 (20%)      2 (13%)      3 (20%)                               
      Site of Application - Epidermis,                                                                                              
        Hyperkeratosis                                 2 (13%)      7 (47%)     15 (100%)    14 (93%)                               
      Site of Application - Epidermis, Hyperplasia                  2 (13%)     11 (73%)     13 (87%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05    
Route: SKIN APPLICATION                                                                                           Time: 10:06:53    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  1 (7%)                    1 (7%)                                
      Pigmentation                                                                            1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Nephropathy                                      7 (47%)      7 (47%)     11 (73%)     13 (87%)                               
      Renal Tubule, Dilatation                         4 (27%)      2 (13%)      2 (13%)                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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