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TDMS Study 97013-15 Pathology Tables

NTP Experiment-Test: 97013-15  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05
Route: SKIN APPLICATION                                                                                           Time: 10:07:00

                                                       FINAL #1 TGAC MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/13/01

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/KG
                               Include 002    0 MG/KG
                               Include 003    31.25   MG/KG
                               Include 004    31.25   MG/KG
                               Include 005    125MG/KG
                               Include 006    125MG/KG
                               Include 007    500MG/KG
                               Include 008    500MG/KG


























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-15  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: SKIN APPLICATION                                                                                           Time: 10:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4            2            1                                                  
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                11           12           14           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
   Salivary Glands                                    (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Squamous Cell Papilloma                          4 (27%)      5 (33%)      4 (27%)      5 (33%)                               
      Squamous Cell Papilloma, Multiple                3 (20%)      1 (7%)       4 (27%)      2 (13%)                               
   Tooth                                              (5)          (2)          (5)          (2)                                    
      Odontogenic Tumor                                5 (100%)     2 (100%)     5 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
   Adrenal Medulla                                    (15)         (15)         (15)         (15)                                   
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-15  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: SKIN APPLICATION                                                                                           Time: 10:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Spleen                                             (15)         (15)         (15)         (15)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)                                   
      Squamous Cell Papilloma                          6 (40%)      5 (33%)      6 (40%)      2 (13%)                               
      Squamous Cell Papilloma, Multiple                             3 (20%)      2 (13%)                                            
      Site of Application, Squamous Cell Papilloma                                            2 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (14)                                   
      Alveolar/Bronchiolar Adenoma                                  1 (7%)       1 (7%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-15  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: SKIN APPLICATION                                                                                           Time: 10:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(15)        *(15)        *(15)        *(15)                                   
      Leukemia Erythrocytic                            1 (7%)                                 1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-15  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: SKIN APPLICATION                                                                                           Time: 10:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            10          12          12          10                                       
     Total Primary Neoplasms                           20          17          22          14                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                  8          11          11          10                                       
     Total Benign Neoplasms                            13          15          17          11                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               2                                   1                                       
     Total Malignant Neoplasms                          2                                   1                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  5           2           5           2                                       
     Total Uncertain Neoplasms                          5           2           5           2                                       
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-15  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: SKIN APPLICATION                                                                                           Time: 10:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2                                      2                                     
    Natural Death                                                   1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           14           14           12                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Salivary Glands                                    (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Squamous Cell Papilloma                                       4 (27%)      3 (20%)      3 (20%)                               
      Squamous Cell Papilloma, Multiple                1 (7%)       2 (13%)                                                         
   Tooth                                              (2)          (3)          (1)          (4)                                    
      Odontogenic Tumor                                2 (100%)     3 (100%)     1 (100%)     4 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-15  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: SKIN APPLICATION                                                                                           Time: 10:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)                                   
      Squamous Cell Papilloma                          5 (33%)      3 (20%)      2 (13%)      3 (20%)                               
      Squamous Cell Papilloma, Multiple                             2 (13%)      1 (7%)       2 (13%)                               
      Site of Application, Keratoacanthoma                                                    1 (7%)                                
      Site of Application, Squamous Cell Papilloma                               1 (7%)       1 (7%)                                
      Site of Application, Squamous Cell Papilloma,                                                                                 
           Multiple                                                                           1 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Alveolar/Bronchiolar Adenoma                     1 (7%)                    1 (7%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-15  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: SKIN APPLICATION                                                                                           Time: 10:07:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)             7          11           8           8                                       
     Total Primary Neoplasms                           10          14           9          15                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                  6          10           8           7                                       
     Total Benign Neoplasms                             7          11           8          11                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
     Total Malignant Neoplasms                          1                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2           3           1           4                                       
     Total Uncertain Neoplasms                          2           3           1           4                                       
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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