TDMS Study 97013-15 Pathology Tables
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:07:00
FINAL #1 TGAC MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/13/01
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG
Include 002 0 MG/KG
Include 003 31.25 MG/KG
Include 004 31.25 MG/KG
Include 005 125MG/KG
Include 006 125MG/KG
Include 007 500MG/KG
Include 008 500MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:07:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Natural Death 4 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 11 12 14 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Salivary Glands (1)
Carcinoma 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Squamous Cell Papilloma 4 (27%) 5 (33%) 4 (27%) 5 (33%)
Squamous Cell Papilloma, Multiple 3 (20%) 1 (7%) 4 (27%) 2 (13%)
Tooth (5) (2) (5) (2)
Odontogenic Tumor 5 (100%) 2 (100%) 5 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Adrenal Medulla (15) (15) (15) (15)
Pituitary Gland (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:07:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Squamous Cell Papilloma 6 (40%) 5 (33%) 6 (40%) 2 (13%)
Squamous Cell Papilloma, Multiple 3 (20%) 2 (13%)
Site of Application, Squamous Cell Papilloma 2 (13%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (14)
Alveolar/Bronchiolar Adenoma 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:07:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:07:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 10 12 12 10
Total Primary Neoplasms 20 17 22 14
Total Animals with Benign Neoplasms 8 11 11 10
Total Benign Neoplasms 13 15 17 11
Total Animals with Malignant Neoplasms 2 1
Total Malignant Neoplasms 2 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 5 2 5 2
Total Uncertain Neoplasms 5 2 5 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:07:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 2
Natural Death 1 1 1
Survivors
Terminal Sacrifice 13 14 14 12
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Salivary Glands (1)
Carcinoma 1 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Squamous Cell Papilloma 4 (27%) 3 (20%) 3 (20%)
Squamous Cell Papilloma, Multiple 1 (7%) 2 (13%)
Tooth (2) (3) (1) (4)
Odontogenic Tumor 2 (100%) 3 (100%) 1 (100%) 4 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:07:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Squamous Cell Papilloma 5 (33%) 3 (20%) 2 (13%) 3 (20%)
Squamous Cell Papilloma, Multiple 2 (13%) 1 (7%) 2 (13%)
Site of Application, Keratoacanthoma 1 (7%)
Site of Application, Squamous Cell Papilloma 1 (7%) 1 (7%)
Site of Application, Squamous Cell Papilloma,
Multiple 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Alveolar/Bronchiolar Adenoma 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
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NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:07:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 7 11 8 8
Total Primary Neoplasms 10 14 9 15
Total Animals with Benign Neoplasms 6 10 8 7
Total Benign Neoplasms 7 11 8 11
Total Animals with Malignant Neoplasms 1
Total Malignant Neoplasms 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2 3 1 4
Total Uncertain Neoplasms 2 3 1 4
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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