TDMS Study 97013-15 Pathology Tables
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28
FINAL #1 TGAC MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/13/01
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG
Include 002 0 MG/KG
Include 003 31.25 MG/KG
Include 004 31.25 MG/KG
Include 005 125MG/KG
Include 006 125MG/KG
Include 007 500MG/KG
Include 008 500MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 4 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 11 12 14 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Inflammation, Chronic Active 11 [1.1] 13 [1.0] 14 [1.1] 11 [1.0]
Hepatocyte, Necrosis 1 [1.0] 3 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 6 [1.2] 4 [1.0] 14 [2.1] 15 [3.3]
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 1 [2.0]
Epithelium, Hyperplasia 1 [2.0] 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 2 [1.5] 7 [1.3] 4 [1.8]
Subcapsular, Hyperplasia 5 [1.0] 8 [1.0] 6 [1.0] 9 [1.0]
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 3 [1.0] 4 [1.0] 3 [1.0] 3 [1.3]
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 [2.0]
Follicle, Degeneration 5 [1.0] 4 [1.3] 2 [1.5] 1 [1.0]
Follicular Cell, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 3 [2.0] 2 [2.0] 1 [2.0] 1 [2.0]
Uterus (15) (15) (15) (15)
Endometrium, Hyperplasia, Cystic 10 [1.5] 12 [1.7] 10 [1.6] 14 [1.4]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 3 [2.3] 1 [2.0] 4 [2.5] 2 [3.5]
Thymus (15) (15) (15) (15)
Atrophy 3 [3.3] 1 [4.0] 1 [3.0]
Cyst 3 [1.3] 8 [1.1] 7 [1.1] 9 [1.3]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Hyperkeratosis 1 [3.0] 1 [3.0]
Inflammation, Chronic Active 1 [2.0]
Epidermis, Hyperplasia 3 [2.7] 1 [2.0] 1 [4.0] 2 [2.5]
Site of Application - Epidermis,
Hyperkeratosis 8 [1.3] 9 [1.0] 14 [1.6] 14 [1.9]
Site of Application - Epidermis, Hyperplasia 1 [1.0] 10 [1.0] 13 [1.8]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (14)
Inflammation, Chronic Active 1 [1.0] 1 [3.0]
Thrombosis 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 1 [2.0] 1 [4.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Nephropathy 3 [1.0] 6 [1.0] 5 [1.0] 5 [1.0]
Renal Tubule, Dilatation 2 [1.5] 3 [1.7] 3 [2.7] 1 [1.0]
Renal Tubule, Hyperplasia 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 2
Natural Death 1 1 1
Survivors
Terminal Sacrifice 13 14 14 12
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 3 [1.3]
Inflammation, Chronic Active 2 [1.0] 8 [1.0] 4 [1.0] 2 [1.5]
Pigmentation 1 [1.0]
Hepatocyte, Necrosis 1 [2.0] 2 [1.0] 2 [1.5]
Hepatocyte, Vacuolization Cytoplasmic 3 [1.0] 4 [1.0] 14 [1.8] 15 [2.8]
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 1 [1.0]
Epithelium, Hyperplasia 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hypertrophy 11 [1.2] 7 [1.0] 7 [1.1] 7 [1.0]
Subcapsular, Hyperplasia 4 [1.0] 1 [1.0] 2 [1.0]
Parathyroid Gland (1)
Cyst 1 [2.0]
Pituitary Gland (15) (15) (14) (15)
Pars Distalis, Cyst 1 [2.0] 3 [1.3]
Thyroid Gland (15) (15) (15) (15)
Follicle, Degeneration 3 [1.0] 3 [1.3] 2 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Degeneration 2 [4.0] 1 [4.0] 1 [4.0] 1 [4.0]
Inflammation, Chronic Active 1 [1.0]
Testes (15) (15) (15) (15)
Cyst 1 [3.0] 1 [3.0] 1 [3.0]
Germinal Epithelium, Degeneration 2 [3.0] 1 [3.0] 1 [2.0] 2 [1.5]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (14)
Hyperplasia, Lymphoid 2 [2.0] 1 [3.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 3 [2.3]
Thymus (15) (15) (15) (15)
Atrophy 1 [2.0] 1 [3.0] 2 [2.5]
Cyst 6 [1.0] 1 [1.0] 4 [1.0] 2 [1.5]
Thymocyte, Necrosis 2 [2.5]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Epidermis, Hyperplasia 2 [2.5] 3 [3.3] 2 [2.0] 3 [1.7]
Site of Application - Epidermis,
Hyperkeratosis 2 [1.5] 7 [1.1] 15 [1.9] 14 [2.0]
Site of Application - Epidermis, Hyperplasia 2 [1.0] 11 [1.0] 13 [1.8]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 1 [2.0] 1 [1.0]
Pigmentation 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Nephropathy 7 [1.0] 7 [1.0] 11 [1.0] 13 [1.0]
Renal Tubule, Dilatation 4 [2.3] 2 [2.0] 2 [2.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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