Share This:
https://ntp.niehs.nih.gov/go/16275

TDMS Study 97013-15 Pathology Tables

NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:09:28

                                                       FINAL #1 TGAC MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/13/01

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 MG/KG
                               Include 002    0 MG/KG
                               Include 003    31.25   MG/KG
                               Include 004    31.25   MG/KG
                               Include 005    125MG/KG
                               Include 006    125MG/KG
                               Include 007    500MG/KG
                               Include 008    500MG/KG

























a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4            2            1                                                  
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                11           12           14           15                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                    11 [1.1]     13 [1.0]     14 [1.1]     11 [1.0]                               
      Hepatocyte, Necrosis                             1 [1.0]                                3 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            6 [1.2]      4 [1.0]     14 [2.1]     15 [3.3]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                       1 [2.0]                                                                      
      Epithelium, Hyperplasia                          1 [2.0]      1 [2.0]      1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Accessory Adrenal Cortical Nodule                             2 [1.5]      7 [1.3]      4 [1.8]                               
      Subcapsular, Hyperplasia                         5 [1.0]      8 [1.0]      6 [1.0]      9 [1.0]                               
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Cyst                              3 [1.0]      4 [1.0]      3 [1.0]      3 [1.3]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Ectopic Thymus                                                1 [2.0]                                                         
      Follicle, Degeneration                           5 [1.0]      4 [1.3]      2 [1.5]      1 [1.0]                               
      Follicular Cell, Hyperplasia                                               1 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (15)         (15)         (15)         (15)                                   
      Cyst                                             3 [2.0]      2 [2.0]      1 [2.0]      1 [2.0]                               
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Endometrium, Hyperplasia, Cystic                10 [1.5]     12 [1.7]     10 [1.6]     14 [1.4]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (15)                                   
      Hyperplasia, Lymphoid                            3 [2.3]      1 [2.0]      4 [2.5]      2 [3.5]                               
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          3 [3.3]      1 [4.0]      1 [3.0]                                            
      Cyst                                             3 [1.3]      8 [1.1]      7 [1.1]      9 [1.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)                                   
      Hyperkeratosis                                   1 [3.0]                   1 [3.0]                                            
      Inflammation, Chronic Active                     1 [2.0]                                                                      
      Epidermis, Hyperplasia                           3 [2.7]      1 [2.0]      1 [4.0]      2 [2.5]                               
      Site of Application - Epidermis,                                                                                              
        Hyperkeratosis                                 8 [1.3]      9 [1.0]     14 [1.6]     14 [1.9]                               
      Site of Application - Epidermis, Hyperplasia                  1 [1.0]     10 [1.0]     13 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (14)                                   
      Inflammation, Chronic Active                     1 [1.0]                                1 [3.0]                               
      Thrombosis                                                                              1 [4.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                                           1 [2.0]      1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Nephropathy                                      3 [1.0]      6 [1.0]      5 [1.0]      5 [1.0]                               
      Renal Tubule, Dilatation                         2 [1.5]      3 [1.7]      3 [2.7]      1 [1.0]                               
      Renal Tubule, Hyperplasia                                                  1 [2.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2                                      2                                     
    Natural Death                                                   1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                13           14           14           12                                     
                                                                                                                                    
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 3 [1.3]                                                                      
      Inflammation, Chronic Active                     2 [1.0]      8 [1.0]      4 [1.0]      2 [1.5]                               
      Pigmentation                                                                            1 [1.0]                               
      Hepatocyte, Necrosis                             1 [2.0]      2 [1.0]                   2 [1.5]                               
      Hepatocyte, Vacuolization Cytoplasmic            3 [1.0]      4 [1.0]     14 [1.8]     15 [2.8]                               
   Stomach, Forestomach                               (15)         (15)         (15)         (15)                                   
      Epithelium, Hyperkeratosis                                                              1 [1.0]                               
      Epithelium, Hyperplasia                          1 [2.0]                                1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (15)         (15)         (15)         (15)                                   
      Hypertrophy                                     11 [1.2]      7 [1.0]      7 [1.1]      7 [1.0]                               
      Subcapsular, Hyperplasia                         4 [1.0]      1 [1.0]      2 [1.0]                                            
   Parathyroid Gland                                               (1)                                                              
      Cyst                                                          1 [2.0]                                                         
   Pituitary Gland                                    (15)         (15)         (14)         (15)                                   
      Pars Distalis, Cyst                                           1 [2.0]                   3 [1.3]                               
   Thyroid Gland                                      (15)         (15)         (15)         (15)                                   
      Follicle, Degeneration                           3 [1.0]      3 [1.3]      2 [1.0]      1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (15)         (15)         (15)         (15)                                   
      Degeneration                                     2 [4.0]      1 [4.0]      1 [4.0]      1 [4.0]                               
      Inflammation, Chronic Active                                                            1 [1.0]                               
   Testes                                             (15)         (15)         (15)         (15)                                   
      Cyst                                                          1 [3.0]      1 [3.0]      1 [3.0]                               
      Germinal Epithelium, Degeneration                2 [3.0]      1 [3.0]      1 [2.0]      2 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (15)         (15)         (15)         (14)                                   
      Hyperplasia, Lymphoid                                         2 [2.0]                   1 [3.0]                               
   Spleen                                             (15)         (15)         (15)         (15)                                   
      Hematopoietic Cell Proliferation                 3 [2.3]                                                                      
   Thymus                                             (15)         (15)         (15)         (15)                                   
      Atrophy                                          1 [2.0]      1 [3.0]                   2 [2.5]                               
      Cyst                                             6 [1.0]      1 [1.0]      4 [1.0]      2 [1.5]                               
      Thymocyte, Necrosis                                                                     2 [2.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (15)         (15)         (15)         (15)                                   
      Epidermis, Hyperplasia                           2 [2.5]      3 [3.3]      2 [2.0]      3 [1.7]                               
      Site of Application - Epidermis,                                                                                              
        Hyperkeratosis                                 2 [1.5]      7 [1.1]     15 [1.9]     14 [2.0]                               
      Site of Application - Epidermis, Hyperplasia                  2 [1.0]     11 [1.0]     13 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-15         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: SUBCHRON 26-WEEK                         WITH AVERAGE SEVERITY GRADES[b]                              Date: 01/27/05    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 10:09:28    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (15)         (15)         (15)         (15)                                   
      Inflammation, Chronic Active                                  1 [2.0]                   1 [1.0]                               
      Pigmentation                                                                            1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (15)         (15)         (15)         (15)                                   
      Nephropathy                                      7 [1.0]      7 [1.0]     11 [1.0]     13 [1.0]                               
      Renal Tubule, Dilatation                         4 [2.3]      2 [2.0]      2 [2.5]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------