National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16283

TDMS Study 97013-89 Pathology Tables

NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03
Route: SKIN APPLICATION                                                                                           Time: 09:24:30

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: SKIN APPLICATION                                                                                           Time: 09:24:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            3            2            2                                     
    Natural Death                                                   2            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8            5            6            8                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     9 (90%)      9 (90%)      8 (80%)     10 (100%)                              
      Hepatocyte, Necrosis                             2 (20%)      1 (10%)                   5 (50%)                               
      Hepatocyte, Vacuolization Cytoplasmic            7 (70%)      6 (60%)      8 (80%)     10 (100%)                              
   Salivary Glands                                                 (1)          (1)                                                 
      Degeneration                                                  1 (100%)                                                        
   Tooth                                              (4)          (2)          (3)          (3)                                    
      Inflammation, Chronic                                                                   1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                3 (30%)                   2 (20%)                                            
      Mineralization                                   3 (30%)      1 (10%)      2 (20%)                                            
      Subcapsular, Hyperplasia                         7 (70%)      6 (60%)      8 (80%)      5 (50%)                               
   Pituitary Gland                                    (10)         (10)         (9)          (10)                                   
      Pars Distalis, Cyst                              1 (10%)      2 (20%)      2 (22%)                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicle, Degeneration                           2 (20%)      6 (60%)      2 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: SKIN APPLICATION                                                                                           Time: 09:24:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Cyst                                             2 (20%)      1 (10%)      1 (10%)      2 (20%)                               
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     1 (10%)                                                                      
      Endometrium, Hyperplasia, Cystic                 9 (90%)      8 (80%)      8 (80%)      8 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (9)          (10)         (10)                                   
      Hyperplasia, Lymphoid                            2 (20%)      3 (33%)      3 (30%)      2 (20%)                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                                           1 (10%)                                            
   Thymus                                             (10)         (10)         (9)          (10)                                   
      Atrophy                                          3 (30%)      3 (30%)      2 (22%)      1 (10%)                               
      Cyst                                             5 (50%)      2 (20%)      2 (22%)      3 (30%)                               
      Thymocyte, Necrosis                                           1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Fibrosis                                                                   1 (10%)                                            
      Hyperkeratosis                                                             1 (10%)                                            
      Inflammation, Chronic Active                                               3 (30%)                                            
      Ulcer                                                                      2 (20%)                                            
      Epidermis, Hyperplasia, Focal                                 1 (10%)      2 (20%)                                            
      Site of Application - Epidermis,                                                                                              
        Hyperkeratosis                                 5 (50%)      8 (80%)      9 (90%)     10 (100%)                              
      Site of Application - Epidermis, Hyperplasia                               3 (30%)      6 (60%)                               
      Site of Application - Epidermis,                                                                                              
        Inflammation, Chronic Active                                             1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: SKIN APPLICATION                                                                                           Time: 09:24:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE            0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
   Spinal Cord                                                                               (1)                                    
      Necrosis                                                                                1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     2 (20%)                                                                      
      Alveolar Epithelium, Hyperplasia                                                        1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Nephropathy                                      4 (40%)      2 (20%)      3 (30%)      2 (20%)                               
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          1 (10%)                                                                      
      Renal Tubule, Dilatation                         1 (10%)      2 (20%)      1 (10%)      1 (10%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: SKIN APPLICATION                                                                                           Time: 09:24:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            3            1            2                                     
    Natural Death                                                   1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            6            8            7                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Cyst                                                                       1 (10%)                                            
      Inflammation, Chronic Active                     6 (60%)      7 (70%)      5 (50%)      5 (50%)                               
      Mineralization                                   1 (10%)                                                                      
      Hepatocyte, Necrosis                             1 (10%)                   2 (20%)      6 (60%)                               
      Hepatocyte, Vacuolization Cytoplasmic            9 (90%)      7 (70%)      8 (80%)     10 (100%)                              
   Mesentery                                          (1)                       (2)                                                 
      Fat, Fibrosis                                                              2 (100%)                                           
      Fat, Mineralization                              1 (100%)                  1 (50%)                                            
      Fat, Necrosis                                    1 (100%)                  2 (100%)                                           
   Salivary Glands                                                              (1)          (1)                                    
      Atrophy                                                                    1 (100%)     1 (100%)                              
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Epithelium, Hyperkeratosis                                    1 (10%)                                                         
      Epithelium, Hyperplasia                                       1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                                                       1 (10%)                               
      Hypertrophy                                      8 (80%)      8 (80%)      6 (60%)      7 (70%)                               
      Subcapsular, Hyperplasia                                      1 (10%)      1 (10%)      1 (10%)                               
   Pituitary Gland                                    (9)          (10)         (9)          (10)                                   
      Pars Distalis, Cyst                                           2 (20%)      1 (11%)                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: SKIN APPLICATION                                                                                           Time: 09:24:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicle, Degeneration                           2 (20%)      2 (20%)      2 (20%)      2 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Degeneration                                     3 (30%)      2 (20%)      1 (10%)      1 (10%)                               
   Preputial Gland                                    (1)                                                                           
      Duct, Ectasia                                    1 (100%)                                                                     
   Testes                                             (10)         (10)         (10)         (10)                                   
      Cyst                                             3 (30%)      1 (10%)      1 (10%)                                            
      Germinal Epithelium, Degeneration                3 (30%)      2 (20%)      1 (10%)      8 (80%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                         3 (30%)      1 (10%)      1 (10%)                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 (10%)                                                         
   Thymus                                             (9)          (10)         (10)         (9)                                    
      Atrophy                                                       3 (30%)      1 (10%)      4 (44%)                               
      Cyst                                             3 (33%)      4 (40%)      2 (20%)      3 (33%)                               
      Thymocyte, Necrosis                                                        1 (10%)      1 (11%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Cyst Epithelial Inclusion                                                  1 (10%)                                            
      Hyperplasia                                                                1 (10%)      1 (10%)                               
      Inflammation, Chronic Active                                                            2 (20%)                               
      Epidermis, Hyperplasia, Focal                    3 (30%)      1 (10%)                                                         
      Sebaceous Gland, Cyst                                         1 (10%)                                                         
      Site of Application - Dermis, Inflammation,                                                                                   
         Chronic Active                                                                       1 (10%)                               
      Site of Application - Epidermis,                                                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: SKIN APPLICATION                                                                                           Time: 09:24:30    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE              0 MG/KG      31.25        125MG/KG     500MG/KG                                  
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
        Hyperkeratosis                                 2 (20%)      8 (80%)      9 (90%)     10 (100%)                              
      Site of Application - Epidermis, Hyperplasia                               8 (80%)      9 (90%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Alveolar Epithelium, Hyperplasia                                                        1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Cyst                                             2 (20%)                   1 (10%)                                            
      Infiltration Cellular, Plasma Cell                            1 (10%)                                                         
      Mineralization                                   2 (20%)                                                                      
      Nephropathy                                      2 (20%)      7 (70%)      7 (70%)      8 (80%)                               
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          1 (10%)                                                                      
      Renal Tubule, Dilatation                         1 (10%)      4 (40%)      4 (40%)      4 (40%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.