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TDMS Study 97013-89 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    DATE: 12/05/03       
EXPERIMENT: 97013 TEST: 89                                                                                     TIME: 09:29:20       
TEST TYPE:  26-39 WEEKS                         CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 97013D       
PATHOLOGIST: MISSING                                                                                           CAS: 79-43-6         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                            FINAL#1 MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    DATE: 12/05/03       
EXPERIMENT: 97013 TEST: 89                                                                                     TIME: 09:29:20       
TEST TYPE:  26-39 WEEKS                         CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-65406                              ROUTE: SKIN APPLICATION                                        NTP C#: 97013D       
PATHOLOGIST: MISSING                                                                                           CAS: 79-43-6         
                                                                                                                                    
                                                                                                                                    
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF     WATER DISINFECTION MODEL (DICHLOROACET                                                                       
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Kidney                                 Mineralization                                                                               
                                       Nephropathy                                                                                  
Liver: Hepatocyte                      Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Skin                                   Inflammation Chronic                                                                         
Skin: Epidermis                        Hyperplasia Focal                                                                            
Skin: Site of Application - Epidermis  Hyperkeratosis                                                                               
                                       Hyperplasia                                                                                  
Testes                                 Cyst                                                                                         
Testes: Germinal Epithelium            Degeneration                                                                                 
Thymus                                 Atrophy                                                                                      
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Adrenal Cortex                         Accessory Adrenal Cortical Nodule                                                            
                                       Mineralization                                                                               
Liver: Hepatocyte                      Necrosis                                                                                     
                                       Vacuolization Cytoplasmic                                                                    
Lung                                   Inflammation Chronic                                                                         
Skin: Site of Application - Epidermis  Hyperkeratosis                                                                               
                                       Hyperplasia                                                                                  
Thyroid Gland: Follicle                Degeneration                                                                                 
===============================================================                                                                     
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 1       
Statistical Analysis of Non-neoplastic Lesions in        Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHL
OROACET                                                                                                                             
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Accessory Adrenal Cortical Nodule                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    1/10 (10%)  |3/10 (30%)   0/10 (0%)    2/10 (20%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/9.46       0/7.30       0/9.02       1/8.95      |3/9.08       0/7.11       2/8.71       0/8.73       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         11.2%       |33.0%        0.0%         23.0%        0.0%         | 
|TERMINAL (d)       |     0/9 (0%)     0/6 (0%)     0/8 (0%)     0/7 (0%)    |2/8 (25%)    0/5 (0%)     2/6 (33%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          225         |146          ---          274 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.244      (e)          (e)          P=0.500     |P=0.152N     P=0.185N     P=0.612N     P=0.119N     | 
|POLY 3             |     P=0.236      (e)          (e)          P=0.489     |P=0.130N     P=0.142N     P=0.521N     P=0.099N     | 
|POLY 1.5           |     P=0.234      (e)          (e)          P=0.493     |P=0.141N     P=0.128N     P=0.517N     P=0.100N     | 
|POLY 6             |     P=0.237      (e)          (e)          P=0.485     |P=0.120N     P=0.164N     P=0.533N     P=0.102N     | 
|LOGISTIC REGRESSION|     P=0.204      (e)          (e)          P=0.646     |P=0.174N     P=0.100N     P=0.500N     P=0.105N     | 
|COCH-ARM / FISHERS |     P=0.225      (e)          (e)          P=0.500     |P=0.179N     P=0.105N     P=0.500N     P=0.105N     | 
|ORDER RESTRICTED   |     P=0.110      (e)          (e)          (e)         |P=0.026N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Hypertrophy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     8/10 (80%)   8/10 (80%)   6/10 (60%)   7/10 (70%)  |0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     8/9.46       8/8.75       6/9.02       7/8.51      |0/8.23       0/7.11       0/8.71       0/8.73       | 
|POLY-3 PERCENT (g) |     84.5%        91.4%        66.5%        82.3%       |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     8/9 (89%)    6/6 (100%)   6/8 (75%)    7/7 (100%)  |0/8 (0%)     0/5 (0%)     0/6 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     274 (T)      121          274 (T)      274 (T)     |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.630N     P=0.133      P=0.457N     P=0.550     |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.586N     P=0.618      P=0.354N     P=0.711N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.518N     P=0.654      P=0.334N     P=0.613N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.689      P=0.577      P=0.393N     P=0.750     |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.436N     P=0.454      P=0.457N     P=0.550     |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.450N     P=0.709N     P=0.314N     P=0.500N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.328N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 2       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)   |3/10 (30%)   1/10 (10%)   2/10 (20%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/9.46       0/7.30       0/9.02       0/8.51      |3/8.23       1/7.11       2/8.71       0/8.73       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |36.5%        14.1%        23.0%        0.0%         | 
|TERMINAL (d)       |     0/9 (0%)     0/6 (0%)     0/8 (0%)     0/7 (0%)    |3/8 (38%)    1/5 (20%)    2/6 (33%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |274 (T)      274 (T)      274 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.091N     P=0.482N     P=0.651N     P=0.107N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.092N     P=0.343N     P=0.471N     P=0.080N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.102N     P=0.331N     P=0.483N     P=0.086N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.084N     P=0.372N     P=0.474N     P=0.079N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.091N     P=0.482N     P=0.651N     (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.126N     P=0.291N     P=0.500N     P=0.105N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.032N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex: Subcapsular                                                                                                      | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    1/10 (10%)   1/10 (10%)   1/10 (10%)  |7/10 (70%)   6/10 (60%)   8/10 (80%)   5/10 (50%)   | 
|POLY-3 RATE (b)    |     0/9.46       1/7.30       1/9.46       1/8.95      |7/8.23       6/7.53       8/9.02       5/9.01       | 
|POLY-3 PERCENT (g) |     0.0%         13.7%        10.6%        11.2%       |85.0%        79.6%        88.7%        55.5%        | 
|TERMINAL (d)       |     0/9 (0%)     1/6 (17%)    0/8 (0%)     0/7 (0%)    |7/8 (88%)    4/5 (80%)    5/6 (83%)    4/8 (50%)    | 
|FIRST INCIDENCE    |     ---          274 (T)      225          225         |274 (T)      246          260          246          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.536      P=0.419      P=0.500      P=0.500     |P=0.121N     P=0.349      P=0.221      P=0.312N     | 
|POLY 3             |     P=0.521      P=0.448      P=0.500      P=0.489     |P=0.088N     P=0.653N     P=0.686      P=0.208N     | 
|POLY 1.5           |     P=0.525      P=0.466      P=0.500      P=0.493     |P=0.130N     P=0.635N     P=0.602      P=0.256N     | 
|POLY 6             |     P=0.516      P=0.433      P=0.500      P=0.485     |P=0.066N     P=0.689N     P=0.729      P=0.185N     | 
|LOGISTIC REGRESSION|     P=0.518      P=0.419      P=0.577      P=0.646     |P=0.090N     P=0.769      P=0.698      P=0.224N     | 
|COCH-ARM / FISHERS |     P=0.528      P=0.500      P=0.500      P=0.500     |P=0.258N     P=0.500N     P=0.500      P=0.325N     | 
|ORDER RESTRICTED   |     P=0.297      (e)          (e)          (e)         |P=0.101N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 3       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Epididymis                                                                                                                       | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/10 (30%)   2/10 (20%)   1/10 (10%)   1/10 (10%)  |                                                    | 
|POLY-3 RATE (b)    |     3/10.00      2/8.22       1/9.02       1/8.51      |                                                    | 
|POLY-3 PERCENT (g) |     30.0%        24.3%        11.1%        11.8%       |                                                    | 
|TERMINAL (d)       |     2/9 (22%)    1/6 (17%)    1/8 (13%)    1/7 (14%)   |                                                    | 
|FIRST INCIDENCE    |     212          121          274 (T)      274 (T)     |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.319N     P=0.632N     P=0.332N     P=0.381N    |                                                    | 
|POLY 3             |     P=0.306N     P=0.597N     P=0.332N     P=0.355N    |                                                    | 
|POLY 1.5           |     P=0.297N     P=0.559N     P=0.314N     P=0.328N    |                                                    | 
|POLY 6             |     P=0.319N     P=0.636N     P=0.355N     P=0.388N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.291N     P=0.298N     P=0.255N     P=0.261N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.284N     P=0.500N     P=0.291N     P=0.291N    |                                                    | 
|ORDER RESTRICTED   |     P=0.255N     (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/10 (20%)   0/10 (0%)    1/10 (10%)   0/10 (0%)   |0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     2/9.46       0/7.30       1/9.02       0/8.51      |0/8.23       0/7.11       0/8.71       0/8.73       | 
|POLY-3 PERCENT (g) |     21.1%        0.0%         11.1%        0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     2/9 (22%)    0/6 (0%)     1/8 (13%)    0/7 (0%)    |0/8 (0%)     0/5 (0%)     0/6 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     274 (T)      ---          274 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.316N     P=0.327N     P=0.543N     P=0.290N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.263N     P=0.290N     P=0.518N     P=0.251N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.271N     P=0.267N     P=0.510N     P=0.241N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.261N     P=0.311N     P=0.528N     P=0.264N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.316N     (e)          P=0.543N     (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.294N     P=0.237N     P=0.500N     P=0.237N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.080N     (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 4       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Mineralization                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/10 (20%)   0/10 (0%)    0/10 (0%)    0/10 (0%)   |0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     2/10.00      0/7.30       0/9.02       0/8.51      |0/8.23       0/7.11       0/8.71       0/8.73       | 
|POLY-3 PERCENT (g) |     20.0%        0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/9 (11%)    0/6 (0%)     0/8 (0%)     0/7 (0%)    |0/8 (0%)     0/5 (0%)     0/6 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     212          ---          ---          ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.319N     P=0.311N     P=0.253N     P=0.280N    |(e)          (e)          (e)          (e)          | 
|POLY 3             |     P=0.254N     P=0.306N     P=0.251N     P=0.266N    |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     P=0.267N     P=0.276N     P=0.240N     P=0.249N    |(e)          (e)          (e)          (e)          | 
|POLY 6             |     P=0.245N     P=0.335N     P=0.266N     P=0.287N    |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.309N     P=0.171N     P=0.161N     P=0.145N    |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.304N     P=0.237N     P=0.237N     P=0.237N    |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     P=0.036N*    (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney                                                                                                                           | 
|     Nephropathy                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/10 (20%)   7/10 (70%)   7/10 (70%)   8/10 (80%)  |4/10 (40%)   2/10 (20%)   3/10 (30%)   2/10 (20%)   | 
|POLY-3 RATE (b)    |     2/9.46       7/7.84       7/9.02       8/9.70      |4/8.23       2/7.93       3/8.71       2/8.73       | 
|POLY-3 PERCENT (g) |     21.1%        89.3%        77.6%        82.5%       |48.6%        25.2%        34.4%        22.9%        | 
|TERMINAL (d)       |     2/9 (22%)    6/6 (100%)   7/8 (88%)    6/7 (86%)   |4/8 (50%)    0/5 (0%)     3/6 (50%)    2/8 (25%)    | 
|FIRST INCIDENCE    |     274 (T)      212          274 (T)      174         |274 (T)      212          274 (T)      274 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    P=0.005 **   P=0.016 *    P=0.008 **  |P=0.274N     P=0.498N     P=0.699      P=0.309N     | 
|POLY 3             |     P=0.038 *    P=0.002 **   P=0.011 *    P=0.003 **  |P=0.332N     P=0.328N     P=0.462N     P=0.278N     | 
|POLY 1.5           |     P=0.041 *    P=0.004 **   P=0.016 *    P=0.004 **  |P=0.343N     P=0.338N     P=0.478N     P=0.295N     | 
|POLY 6             |     P=0.033 *    P<0.001 **   P=0.007 **   P=0.003 **  |P=0.330N     P=0.326N     P=0.467N     P=0.276N     | 
|LOGISTIC REGRESSION|     P=0.050      P=0.005 **   P=0.016 *    P=0.014 *   |P=0.319N     P=0.366N     P=0.699      P=0.309N     | 
|COCH-ARM / FISHERS |     P=0.058      P=0.035 *    P=0.035 *    P=0.012 *   |P=0.375N     P=0.314N     P=0.500N     P=0.314N     | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.212N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 5       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Kidney: Renal Tubule                                                                                                             | 
|     Dilatation                                                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   4/10 (40%)   4/10 (40%)   4/10 (40%)  |1/10 (10%)   2/10 (20%)   1/10 (10%)   1/10 (10%)   | 
|POLY-3 RATE (b)    |     1/9.46       4/7.30       4/9.02       4/8.95      |1/8.23       2/7.53       1/8.71       1/8.73       | 
|POLY-3 PERCENT (g) |     10.6%        54.8%        44.4%        44.7%       |12.2%        26.6%        11.5%        11.5%        | 
|TERMINAL (d)       |     1/9 (11%)    4/6 (67%)    4/8 (50%)    3/7 (43%)   |1/8 (13%)    0/5 (0%)     1/6 (17%)    1/8 (13%)    | 
|FIRST INCIDENCE    |     274 (T)      274 (T)      274 (T)      225         |274 (T)      246          274 (T)      274 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.247      P=0.053      P=0.118      P=0.110     |P=0.484N     P=0.398      P=0.702      P=0.768      | 
|POLY 3             |     P=0.285      P=0.067      P=0.127      P=0.125     |P=0.532N     P=0.467      P=0.750N     P=0.750N     | 
|POLY 1.5           |     P=0.295      P=0.090      P=0.136      P=0.133     |P=0.540N     P=0.469      P=0.755N     P=0.756N     | 
|POLY 6             |     P=0.273      P=0.050      P=0.116      P=0.118     |P=0.531N     P=0.461      P=0.752N     P=0.750N     | 
|LOGISTIC REGRESSION|     P=0.278      P=0.053      P=0.118      P=0.134     |P=0.517N     P=0.456      P=0.702      P=0.768      | 
|COCH-ARM / FISHERS |     P=0.303      P=0.152      P=0.152      P=0.152     |P=0.552N     P=0.500      P=0.763N     P=0.763N     | 
|ORDER RESTRICTED   |     P=0.062      (e)          (e)          (e)         |P=0.527N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/10 (60%)   7/10 (70%)   5/10 (50%)   5/10 (50%)  |9/10 (90%)   9/10 (90%)   8/10 (80%)   10/10 (100%) | 
|POLY-3 RATE (b)    |     6/9.46       7/8.29       5/9.46       5/8.95      |9/9.08       9/9.00       8/9.00       10/10.00     | 
|POLY-3 PERCENT (g) |     63.4%        84.5%        52.8%        55.8%       |99.1%        100.0%       88.9%        100.0%       | 
|TERMINAL (d)       |     6/9 (67%)    5/6 (83%)    4/8 (50%)    4/7 (57%)   |8/8 (100%)   5/5 (100%)   6/6 (100%)   8/8 (100%)   | 
|FIRST INCIDENCE    |     274 (T)      212          225          225         |146          113          260          50           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.430N     P=0.138      P=0.600N     P=0.632     |P=0.518N     P=0.149      P=0.528      P=0.514      | 
|POLY 3             |     P=0.356N     P=0.320      P=0.500N     P=0.556N    |P=0.734      P=1.000      P=0.528N     P=1.000      | 
|POLY 1.5           |     P=0.347N     P=0.366      P=0.500N     P=0.535N    |P=0.654      P=0.994      P=0.558N     P=0.992      | 
|POLY 6             |     P=0.375N     P=0.313      P=0.500N     P=0.577N    |P=0.759      P=1.000      P=0.511N     P=1.000      | 
|LOGISTIC REGRESSION|     P=0.340N     P=0.205      P=0.550N     P=0.630N    |P=0.312      P=0.495      P=0.407N     P=0.409      | 
|COCH-ARM / FISHERS |     P=0.349N     P=0.500      P=0.500N     P=0.500N    |P=0.310      P=0.763N     P=0.500N     P=0.500      | 
|ORDER RESTRICTED   |     P=0.310N     (e)          (e)          (e)         |P=0.405N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 6       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/10 (10%)   0/10 (0%)    2/10 (20%)   6/10 (60%)  |2/10 (20%)   1/10 (10%)   0/10 (0%)    5/10 (50%)   | 
|POLY-3 RATE (b)    |     1/9.46       0/7.30       2/9.02       6/9.55      |2/8.23       1/7.26       0/8.71       5/9.72       | 
|POLY-3 PERCENT (g) |     10.6%        0.0%         22.2%        62.8%       |24.3%        13.8%        0.0%         51.4%        | 
|TERMINAL (d)       |     1/9 (11%)    0/6 (0%)     2/8 (25%)    4/7 (57%)   |2/8 (25%)    0/5 (0%)     0/6 (0%)     4/8 (50%)    | 
|FIRST INCIDENCE    |     274 (T)      ---          274 (T)      174         |274 (T)      260          ---          50           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   P=0.581N     P=0.457      P=0.024 *   |P=0.047 *    P=0.643N     P=0.298N     P=0.186      | 
|POLY 3             |     P<0.001 **   P=0.551N     P=0.482      P=0.017 *   |P=0.025 *    P=0.546N     P=0.210N     P=0.249      | 
|POLY 1.5           |     P<0.001 **   P=0.534N     P=0.490      P=0.017 *   |P=0.022 *    P=0.538N     P=0.216N     P=0.229      | 
|POLY 6             |     P<0.001 **   P=0.566N     P=0.471      P=0.016 *   |P=0.027 *    P=0.564N     P=0.211N     P=0.250      | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P=0.457      P=0.038 *   |P=0.021 *    P=0.573N     (e)          P=0.172      | 
|COCH-ARM / FISHERS |     P<0.001 **   P=0.500N     P=0.500      P=0.029 *   |P=0.020 *    P=0.500N     P=0.237N     P=0.175      | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.023 *    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver: Hepatocyte                                                                                                                | 
|     Vacuolization Cytoplasmic                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     9/10 (90%)   7/10 (70%)   8/10 (80%)   10/10 (100%)|7/10 (70%)   6/10 (60%)   8/10 (80%)   10/10 (100%) | 
|POLY-3 RATE (b)    |     9/9.46       7/7.84       8/9.02       10/10.00    |7/8.23       6/7.65       8/9.00       10/10.00     | 
|POLY-3 PERCENT (g) |     95.1%        89.3%        88.7%        100.0%      |85.0%        78.5%        88.9%        100.0%       | 
|TERMINAL (d)       |     9/9 (100%)   6/6 (100%)   8/8 (100%)   7/7 (100%)  |7/8 (88%)    5/5 (100%)   6/6 (100%)   8/8 (100%)   | 
|FIRST INCIDENCE    |     274 (T)      212          274 (T)      174         |274 (T)      212          260          50           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.047 *    P=0.455      P=1.000N     P=0.117     |P=0.200      P=0.291      P=0.151      P=0.131      | 
|POLY 3             |     P=0.391      P=0.736N     P=0.677N     P=0.864     |P=0.175      P=0.627N     P=0.684      P=0.362      | 
|POLY 1.5           |     P=0.259      P=0.519N     P=0.574N     P=0.672     |P=0.111      P=0.615N     P=0.601      P=0.227      | 
|POLY 6             |     P=0.747      P=0.974N     P=0.923N     P=1.000     |P=0.231      P=0.689N     P=0.727      P=0.443      | 
|LOGISTIC REGRESSION|     P=0.078      P=0.761      P=1.000N     P=0.290     |P=0.032 *    P=0.707N     P=0.699      P=0.080      | 
|COCH-ARM / FISHERS |     P=0.157      P=0.291N     P=0.500N     P=0.500     |P=0.041 *    P=0.500N     P=0.500      P=0.105      | 
|ORDER RESTRICTED   |     P=0.199      (e)          (e)          (e)         |P=0.146      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 7       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)   |2/10 (20%)   0/10 (0%)    0/10 (0%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/9.46       0/7.30       0/9.02       0/8.51      |2/8.23       0/7.11       0/8.71       0/8.73       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |24.3%        0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/9 (0%)     0/6 (0%)     0/8 (0%)     0/7 (0%)    |2/8 (25%)    0/5 (0%)     0/6 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |274 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.274N     P=0.341N     P=0.298N     P=0.232N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.271N     P=0.258N     P=0.210N     P=0.210N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.277N     P=0.251N     P=0.216N     P=0.217N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.259N     P=0.276N     P=0.211N     P=0.209N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.274N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.304N     P=0.237N     P=0.237N     P=0.237N     | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.018N*    (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lymph Node, Mandibular                                                                                                           | 
|     Hyperplasia Lymphoid                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    3/10 (30%)   1/10 (10%)   1/10 (10%)  |2/10 (20%)   3/9 (33%)    3/10 (30%)   2/10 (20%)   | 
|POLY-3 RATE (b)    |     0/9.46       3/8.55       1/9.46       1/8.95      |2/9.08       3/7.93       3/9.00       2/9.01       | 
|POLY-3 PERCENT (g) |     0.0%         35.1%        10.6%        11.2%       |22.0%        37.9%        33.3%        22.2%        | 
|TERMINAL (d)       |     0/9 (0%)     1/6 (17%)    0/8 (0%)     0/7 (0%)    |1/8 (13%)    1/5 (20%)    1/6 (17%)    1/8 (13%)    | 
|FIRST INCIDENCE    |     ---          160          225          225         |146          212          260          246          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.560N     P=0.083      P=0.500      P=0.500     |P=0.432N     P=0.394      P=0.469      P=0.684N     | 
|POLY 3             |     P=0.612N     P=0.074      P=0.500      P=0.489     |P=0.487N     P=0.431      P=0.496      P=0.702      | 
|POLY 1.5           |     P=0.602N     P=0.079      P=0.500      P=0.493     |P=0.496N     P=0.437      P=0.491      P=0.696      | 
|POLY 6             |     P=0.620N     P=0.072      P=0.500      P=0.485     |P=0.480N     P=0.423      P=0.498      P=0.704      | 
|LOGISTIC REGRESSION|     P=0.623N     P=0.186      P=0.577      P=0.646     |P=0.487N     P=0.445      P=0.497      P=0.711      | 
|COCH-ARM / FISHERS |     P=0.582N     P=0.105      P=0.500      P=0.500     |P=0.487N     P=0.444      P=0.500      P=0.709N     | 
|ORDER RESTRICTED   |     P=0.186      (e)          (e)          (e)         |P=0.537      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 8       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Fibrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/1 (0%)     0/0 (0%)     2/2 (100%)   0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     0/1.00       0/0.00       2/2.00       0/0.00      |0/0.00       0/0.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         100.0%       0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/1 (0%)     0/0 (0%)     2/2 (100%)   0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          274 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.961      (e)          P=0.362      (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          P=0.333N     (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          P=0.333N     (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          P=0.333N     (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          P=0.362      (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.985      (e)          P=0.333      (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Mesentery: Fat                                                                                                                   | 
|     Necrosis                                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/1 (100%)   0/0 (0%)     2/2 (100%)   0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|POLY-3 RATE (b)    |     1/1.00       0/0.00       2/2.00       0/0.00      |0/0.00       0/0.00       0/0.00       0/0.00       | 
|POLY-3 PERCENT (g) |     100.0%       0.0%         100.0%       0.0%        |0.0%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     1/1 (100%)   0/0 (0%)     2/2 (100%)   0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     | 
|FIRST INCIDENCE    |     274 (T)      ---          274 (T)      ---         |---          ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 9       
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/10 (20%)   1/10 (10%)   1/10 (10%)   2/10 (20%)   | 
|POLY-3 RATE (b)    |                                                        |2/8.23       1/8.04       1/8.71       2/8.73       | 
|POLY-3 PERCENT (g) |                                                        |24.3%        12.4%        11.5%        22.9%        | 
|TERMINAL (d)       |                                                        |2/8 (25%)    0/5 (0%)     1/6 (17%)    2/8 (25%)    | 
|FIRST INCIDENCE    |                                                        |274 (T)      113          274 (T)      274 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.582      P=0.622N     P=0.607N     P=0.712      | 
|POLY 3             |                                                        |P=0.541      P=0.509N     P=0.479N     P=0.685N     | 
|POLY 1.5           |                                                        |P=0.529      P=0.508N     P=0.488N     P=0.695N     | 
|POLY 6             |                                                        |P=0.552      P=0.527N     P=0.482N     P=0.685N     | 
|LOGISTIC REGRESSION|                                                        |P=0.520      P=0.476N     P=0.607N     P=0.712      | 
|COCH-ARM / FISHERS |                                                        |P=0.514      P=0.500N     P=0.500N     P=0.709N     | 
|ORDER RESTRICTED   |                                                        |P=0.516N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis                                                                                                   | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/9 (0%)     2/10 (20%)   1/9 (11%)    0/10 (0%)   |1/10 (10%)   2/10 (20%)   2/9 (22%)    0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/9.00       2/7.75       1/8.02       0/8.51      |1/8.23       2/7.65       2/7.86       0/8.73       | 
|POLY-3 PERCENT (g) |     0.0%         25.8%        12.5%        0.0%        |12.2%        26.2%        25.5%        0.0%         | 
|TERMINAL (d)       |     0/9 (0%)     1/6 (17%)    1/7 (14%)    0/7 (0%)    |1/8 (13%)    1/5 (20%)    2/6 (33%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          225          274 (T)      ---         |274 (T)      212          274 (T)      ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.372N     P=0.171      P=0.450      (e)         |P=0.185N     P=0.390      P=0.393      P=0.500N     | 
|POLY 3             |     P=0.404N     P=0.190      P=0.477      (e)         |P=0.198N     P=0.473      P=0.483      P=0.488N     | 
|POLY 1.5           |     P=0.381N     P=0.208      P=0.487      (e)         |P=0.207N     P=0.473      P=0.472      P=0.494N     | 
|POLY 6             |     P=0.430N     P=0.176      P=0.464      (e)         |P=0.195N     P=0.463      P=0.485      P=0.488N     | 
|LOGISTIC REGRESSION|     P=0.346N     P=0.248      P=0.450      (e)         |P=0.200N     P=0.468      P=0.393      (e)          | 
|COCH-ARM / FISHERS |     P=0.346N     P=0.263      P=0.500      (e)         |P=0.220N     P=0.500      P=0.458      P=0.500N     | 
|ORDER RESTRICTED   |     P=0.279      (e)          (e)          (e)         |P=0.174N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 10      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Inflammation Chronic                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    2/10 (20%)  |0/10 (0%)    0/10 (0%)    3/10 (30%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/9.46       0/7.30       0/9.02       2/8.51      |0/8.23       0/7.11       3/8.87       0/8.73       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         23.5%       |0.0%         0.0%         33.8%        0.0%         | 
|TERMINAL (d)       |     0/9 (0%)     0/6 (0%)     0/8 (0%)     2/7 (29%)   |0/8 (0%)     0/5 (0%)     1/6 (17%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          274 (T)     |---          ---          260          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.033 *    (e)          (e)          P=0.178     |P=0.533N     (e)          P=0.106      (e)          | 
|POLY 3             |     P=0.033 *    (e)          (e)          P=0.200     |P=0.523N     (e)          P=0.105      (e)          | 
|POLY 1.5           |     P=0.034 *    (e)          (e)          P=0.210     |P=0.548N     (e)          P=0.099      (e)          | 
|POLY 6             |     P=0.031 *    (e)          (e)          P=0.187     |P=0.506N     (e)          P=0.107      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          P=0.178     |P=0.550N     (e)          P=0.111      (e)          | 
|COCH-ARM / FISHERS |     P=0.039 *    (e)          (e)          P=0.237     |P=0.584N     (e)          P=0.105      (e)          | 
|ORDER RESTRICTED   |     P=0.016 *    (e)          (e)          (e)         |P=0.138      (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Ulcer                                                                                                                       | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    0/10 (0%)    0/10 (0%)   |0/10 (0%)    0/10 (0%)    2/10 (20%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     0/9.46       0/7.30       0/9.02       0/8.51      |0/8.23       0/7.11       2/8.86       0/8.73       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         22.6%        0.0%         | 
|TERMINAL (d)       |     0/9 (0%)     0/6 (0%)     0/8 (0%)     0/7 (0%)    |0/8 (0%)     0/5 (0%)     1/6 (17%)    0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          260          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.614N     (e)          P=0.220      (e)          | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.613N     (e)          P=0.242      (e)          | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.630N     (e)          P=0.234      (e)          | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.602N     (e)          P=0.244      (e)          | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.632N     (e)          P=0.236      (e)          | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.655N     (e)          P=0.237      (e)          | 
|ORDER RESTRICTED   |     (e)          (e)          (e)          (e)         |P=0.242      (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 11      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Epidermis                                                                                                                  | 
|     Hyperplasia Focal                                                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/10 (30%)   1/10 (10%)   0/10 (0%)    0/10 (0%)   |0/10 (0%)    1/10 (10%)   2/10 (20%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     3/9.46       1/7.30       0/9.02       0/8.51      |0/8.23       1/7.11       2/8.87       0/8.73       | 
|POLY-3 PERCENT (g) |     31.7%        13.7%        0.0%         0.0%        |0.0%         14.1%        22.6%        0.0%         | 
|TERMINAL (d)       |     3/9 (33%)    1/6 (17%)    0/8 (0%)     0/7 (0%)    |0/8 (0%)     1/5 (20%)    0/6 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     274 (T)      274 (T)      ---          ---         |---          274 (T)      260          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.136N     P=0.454N     P=0.130N     P=0.155N    |P=0.429N     P=0.406      P=0.238      (e)          | 
|POLY 3             |     P=0.100N     P=0.394N     P=0.102N     P=0.113N    |P=0.439N     P=0.471      P=0.242      (e)          | 
|POLY 1.5           |     P=0.103N     P=0.357N     P=0.098N     P=0.105N    |P=0.452N     P=0.477      P=0.235      (e)          | 
|POLY 6             |     P=0.099N     P=0.428N     P=0.107N     P=0.123N    |P=0.436N     P=0.457      P=0.244      (e)          | 
|LOGISTIC REGRESSION|     P=0.136N     P=0.454N     (e)          (e)         |P=0.439N     P=0.406      P=0.236      (e)          | 
|COCH-ARM / FISHERS |     P=0.124N     P=0.291N     P=0.105N     P=0.105N    |P=0.472N     P=0.500      P=0.237      (e)          | 
|ORDER RESTRICTED   |     P=0.017N*    (e)          (e)          (e)         |P=0.292N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Site of Application - Epidermis                                                                                            | 
|     Hyperkeratosis                                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/10 (20%)   8/10 (80%)   9/10 (90%)   10/10 (100%)|5/10 (50%)   8/10 (80%)   9/10 (90%)   10/10 (100%) | 
|POLY-3 RATE (b)    |     2/10.00      8/9.20       9/10.00      10/10.00    |5/9.08       8/9.00       9/10.00      10/10.00     | 
|POLY-3 PERCENT (g) |     20.0%        87.0%        90.0%        100.0%      |55.1%        88.9%        90.0%        100.0%       | 
|TERMINAL (d)       |     1/9 (11%)    5/6 (83%)    7/8 (88%)    7/7 (100%)  |4/8 (50%)    4/5 (80%)    5/6 (83%)    8/8 (100%)   | 
|FIRST INCIDENCE    |     212          121          212          174         |146          113          68           50           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.023 *    P=0.009 **   P=0.009 **   P=0.002 **  |P=0.269      P=0.072      P=0.070      P=0.057      | 
|POLY 3             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.054      P=0.136      P=0.107      P=0.019 *    | 
|POLY 1.5           |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.044 *    P=0.121      P=0.092      P=0.014 *    | 
|POLY 6             |     P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **  |P=0.058      P=0.142      P=0.113      P=0.022 *    | 
|LOGISTIC REGRESSION|     P=0.005 **   P=0.023 *    (e)          (e)         |P=0.033 *    P=0.134      P=0.071      P=0.020 *    | 
|COCH-ARM / FISHERS |     P=0.006 **   P=0.012 *    P=0.003 **   P<0.001 **  |P=0.031 *    P=0.175      P=0.070      P=0.016 *    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P=0.002 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 12      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin: Site of Application - Epidermis                                                                                            | 
|     Hyperplasia                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/10 (0%)    0/10 (0%)    8/10 (80%)   9/10 (90%)  |0/10 (0%)    0/10 (0%)    3/10 (30%)   6/10 (60%)   | 
|POLY-3 RATE (b)    |     0/9.46       0/7.30       8/9.55       9/9.26      |0/8.23       0/7.11       3/8.71       6/9.72       | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         83.7%        97.2%       |0.0%         0.0%         34.4%        61.7%        | 
|TERMINAL (d)       |     0/9 (0%)     0/6 (0%)     7/8 (88%)    7/7 (100%)  |0/8 (0%)     0/5 (0%)     3/6 (50%)    5/8 (63%)    | 
|FIRST INCIDENCE    |     ---          ---          212          225         |---          ---          274 (T)      50           | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P=0.002 **   (e)          P=0.062      P=0.010 *    | 
|POLY 3             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.101      P=0.003 **   | 
|POLY 1.5           |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.097      P=0.002 **   | 
|POLY 6             |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.099      P=0.003 **   | 
|LOGISTIC REGRESSION|     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.062      P=0.007 **   | 
|COCH-ARM / FISHERS |     P<0.001 **   (e)          P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P=0.105      P=0.005 **   | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |P<0.001 **   (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/10 (30%)   1/10 (10%)   1/10 (10%)   0/10 (0%)   |                                                    | 
|POLY-3 RATE (b)    |     3/10.00      1/7.30       1/9.02       0/8.51      |                                                    | 
|POLY-3 PERCENT (g) |     30.0%        13.7%        11.1%        0.0%        |                                                    | 
|TERMINAL (d)       |     2/9 (22%)    1/6 (17%)    1/8 (13%)    0/7 (0%)    |                                                    | 
|FIRST INCIDENCE    |     212          274 (T)      274 (T)      ---         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.145N     P=0.438N     P=0.332N     P=0.157N    |                                                    | 
|POLY 3             |     P=0.115N     P=0.419N     P=0.332N     P=0.127N    |                                                    | 
|POLY 1.5           |     P=0.115N     P=0.372N     P=0.314N     P=0.113N    |                                                    | 
|POLY 6             |     P=0.118N     P=0.463N     P=0.355N     P=0.145N    |                                                    | 
|LOGISTIC REGRESSION|     P=0.126N     P=0.323N     P=0.255N     P=0.074N    |                                                    | 
|COCH-ARM / FISHERS |     P=0.126N     P=0.291N     P=0.291N     P=0.105N    |                                                    | 
|ORDER RESTRICTED   |     P=0.041N*    (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 13      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes: Germinal Epithelium                                                                                                      | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/10 (30%)   2/10 (20%)   1/10 (10%)   8/10 (80%)  |                                                    | 
|POLY-3 RATE (b)    |     3/10.00      2/8.22       1/9.02       8/8.95      |                                                    | 
|POLY-3 PERCENT (g) |     30.0%        24.3%        11.1%        89.4%       |                                                    | 
|TERMINAL (d)       |     2/9 (22%)    1/6 (17%)    1/8 (13%)    7/7 (100%)  |                                                    | 
|FIRST INCIDENCE    |     212          121          274 (T)      225         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.002 **   P=0.632N     P=0.332N     P=0.018 *   |                                                    | 
|POLY 3             |     P<0.001 **   P=0.597N     P=0.332N     P=0.005 **  |                                                    | 
|POLY 1.5           |     P<0.001 **   P=0.559N     P=0.314N     P=0.010 *   |                                                    | 
|POLY 6             |     P<0.001 **   P=0.636N     P=0.355N     P=0.002 **  |                                                    | 
|LOGISTIC REGRESSION|     P=0.002 **   P=0.298N     P=0.255N     P=0.027 *   |                                                    | 
|COCH-ARM / FISHERS |     P=0.002 **   P=0.500N     P=0.291N     P=0.035 *   |                                                    | 
|ORDER RESTRICTED   |     P<0.001 **   (e)          (e)          (e)         |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Atrophy                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/9 (0%)     3/10 (30%)   1/10 (10%)   4/9 (44%)   |3/10 (30%)   3/10 (30%)   2/9 (22%)    1/10 (10%)   | 
|POLY-3 RATE (b)    |     0/8.46       3/9.46       1/9.46       4/7.95      |3/10.00      3/8.07       2/8.02       1/9.01       | 
|POLY-3 PERCENT (g) |     0.0%         31.7%        10.6%        50.3%       |30.0%        37.2%        25.0%        11.1%        | 
|TERMINAL (d)       |     0/8 (0%)     0/6 (0%)     0/8 (0%)     3/6 (50%)   |1/8 (13%)    0/5 (0%)     0/6 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     ---          121          225          225         |118          212          260          246          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.088      P=0.104      P=0.500      P=0.033 *   |P=0.190N     P=0.564      P=0.535N     P=0.307N     | 
|POLY 3             |     P=0.042 *    P=0.113      P=0.522      P=0.020 *   |P=0.209N     P=0.567      P=0.608N     P=0.333N     | 
|POLY 1.5           |     P=0.046 *    P=0.114      P=0.522      P=0.023 *   |P=0.209N     P=0.582      P=0.602N     P=0.329N     | 
|POLY 6             |     P=0.039 *    P=0.113      P=0.523      P=0.017 *   |P=0.208N     P=0.563      P=0.609N     P=0.333N     | 
|LOGISTIC REGRESSION|     P=0.042 *    P=0.558      P=0.583      P=0.038 *   |P=0.208N     P=0.633N     P=0.573N     P=0.282N     | 
|COCH-ARM / FISHERS |     P=0.062      P=0.124      P=0.526      P=0.041 *   |P=0.196N     P=0.686N     P=0.556N     P=0.291N     | 
|ORDER RESTRICTED   |     P=0.009 **   (e)          (e)          (e)         |P=0.210N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 14      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thymus                                                                                                                           | 
|     Cyst                                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/9 (33%)    4/10 (40%)   2/10 (20%)   3/9 (33%)   |5/10 (50%)   2/10 (20%)   2/9 (22%)    3/10 (30%)   | 
|POLY-3 RATE (b)    |     3/8.46       4/7.30       2/9.46       3/7.95      |5/8.23       2/7.11       2/7.87       3/8.73       | 
|POLY-3 PERCENT (g) |     35.5%        54.8%        21.1%        37.7%       |60.7%        28.1%        25.4%        34.4%        | 
|TERMINAL (d)       |     3/8 (38%)    4/6 (67%)    1/8 (13%)    2/6 (33%)   |5/8 (63%)    2/5 (40%)    1/6 (17%)    3/8 (38%)    | 
|FIRST INCIDENCE    |     274 (T)      274 (T)      225          225         |274 (T)      274 (T)      260          274 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.606      P=0.301      P=0.500N     P=0.554     |P=0.385N     P=0.416N     P=0.297N     P=0.314N     | 
|POLY 3             |     P=0.609N     P=0.399      P=0.444N     P=0.655     |P=0.432N     P=0.220N     P=0.174N     P=0.276N     | 
|POLY 1.5           |     P=0.602N     P=0.459      P=0.445N     P=0.665     |P=0.458N     P=0.208N     P=0.192N     P=0.298N     | 
|POLY 6             |     P=0.619N     P=0.346      P=0.442N     P=0.644     |P=0.412N     P=0.256N     P=0.169N     P=0.274N     | 
|LOGISTIC REGRESSION|     P=0.618N     P=0.301      P=0.442N     P=0.647     |P=0.401N     P=0.416N     P=0.185N     P=0.314N     | 
|COCH-ARM / FISHERS |     P=0.604N     P=0.570      P=0.444N     P=0.690N    |P=0.513N     P=0.175N     P=0.220N     P=0.325N     | 
|ORDER RESTRICTED   |     P=0.408N     (e)          (e)          (e)         |P=0.135N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicle                                                                                                          | 
|     Degeneration                                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/10 (20%)   2/10 (20%)   2/10 (20%)   2/10 (20%)  |2/10 (20%)   6/10 (60%)   2/10 (20%)   0/10 (0%)    | 
|POLY-3 RATE (b)    |     2/10.00      2/7.84       2/9.02       2/8.95      |2/9.08       6/8.07       2/8.87       0/8.73       | 
|POLY-3 PERCENT (g) |     20.0%        25.5%        22.2%        22.3%       |22.0%        74.3%        22.6%        0.0%         | 
|TERMINAL (d)       |     1/9 (11%)    1/6 (17%)    2/8 (25%)    1/7 (14%)   |1/8 (13%)    3/5 (60%)    0/6 (0%)     0/8 (0%)     | 
|FIRST INCIDENCE    |     212          212          274 (T)      225         |146          212          260          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.613      P=0.578      P=0.668      P=0.639     |P=0.036N*    P=0.054      P=0.665      P=0.240N     | 
|POLY 3             |     P=0.629      P=0.609      P=0.664      P=0.662     |P=0.019N*    P=0.034 *    P=0.696      P=0.234N     | 
|POLY 1.5           |     P=0.637      P=0.641      P=0.681      P=0.678     |P=0.019N*    P=0.035 *    P=0.695      P=0.234N     | 
|POLY 6             |     P=0.616      P=0.583      P=0.642      P=0.644     |P=0.020N*    P=0.034 *    P=0.694      P=0.238N     | 
|LOGISTIC REGRESSION|     P=0.643      P=0.665N     P=0.686N     P=0.618N    |P=0.029N*    P=0.069      P=0.708      P=0.220N     | 
|COCH-ARM / FISHERS |     P=0.645      P=0.709N     P=0.709N     P=0.709N    |P=0.031N*    P=0.085      P=0.709N     P=0.237N     | 
|ORDER RESTRICTED   |     P=0.667      (e)          (e)          (e)         |P=0.009N**   (e)          (e)          (e)          | 
|=================================================================================================================================| 
                                                                                                                                   
       Date:  12/05/03                           EXPERIMENT: 97013 TEST: 89                                            Page 15      
Statistical Analysis of Non-neoplastic Lesions in       Mice(TG.AC HETEROZYGOUS TRANSGENIC)  -      WATER DISINFECTION MODEL (DICHLO
ROACET                                                                                                                              
                                         Terminal Sacrifice at 40 weeks                                                             
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     0 MG/KG      31.25        125MG/KG     500MG/KG    |0 MG/KG      31.25        125MG/KG     500MG/KG     | 
|                   |                  MG/KG                                 |             MG/KG                                  | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus: Endometrium                                                                                                              | 
|     Hyperplasia Cystic                                                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|LESION RATES       |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |9/10 (90%)   8/10 (80%)   8/10 (80%)   8/10 (80%)   | 
|POLY-3 RATE (b)    |                                                        |9/9.08       8/8.07       8/8.87       8/8.73       | 
|POLY-3 PERCENT (g) |                                                        |99.1%        99.1%        90.2%        91.6%        | 
|TERMINAL (d)       |                                                        |8/8 (100%)   5/5 (100%)   6/6 (100%)   8/8 (100%)   | 
|FIRST INCIDENCE    |                                                        |146          212          260          274 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.151N     P=0.262      P=0.498      P=0.500N     | 
|POLY 3             |                                                        |P=0.503N     P=1.000      P=0.591N     P=0.674N     | 
|POLY 1.5           |                                                        |P=0.505N     P=0.989N     P=0.587N     P=0.641N     | 
|POLY 6             |                                                        |P=0.589N     P=1.000      P=0.640N     P=0.808N     | 
|LOGISTIC REGRESSION|                                                        |P=0.240N     (e)          P=0.386N     P=0.377N     | 
|COCH-ARM / FISHERS |                                                        |P=0.519N     P=0.500N     P=0.500N     P=0.500N     | 
|ORDER RESTRICTED   |                                                        |P=0.290N     (e)          (e)          (e)          | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).