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TDMS Study 97013-89 Pathology Tables

NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:30:34

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:30:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 2            3            2            2                                     
    Natural Death                                                   2            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 8            5            6            8                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     9 [1.1]      9 [1.0]      8 [1.0]     10 [1.1]                               
      Hepatocyte, Necrosis                             2 [1.0]      1 [1.0]                   5 [1.2]                               
      Hepatocyte, Vacuolization Cytoplasmic            7 [1.0]      6 [1.2]      8 [2.0]     10 [2.7]                               
   Salivary Glands                                                 (1)          (1)                                                 
      Degeneration                                                  1 [3.0]                                                         
   Tooth                                              (4)          (2)          (3)          (3)                                    
      Inflammation, Chronic                                                                   1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                3 [1.7]                   2 [1.5]                                            
      Mineralization                                   3 [1.0]      1 [1.0]      2 [1.0]                                            
      Subcapsular, Hyperplasia                         7 [1.0]      6 [1.0]      8 [1.0]      5 [1.0]                               
   Pituitary Gland                                    (10)         (10)         (9)          (10)                                   
      Pars Distalis, Cyst                              1 [2.0]      2 [1.5]      2 [1.0]                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicle, Degeneration                           2 [1.5]      6 [1.2]      2 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:30:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Cyst                                             2 [2.5]      1 [2.0]      1 [2.0]      2 [1.5]                               
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     1 [1.0]                                                                      
      Endometrium, Hyperplasia, Cystic                 9 [1.9]      8 [2.1]      8 [1.6]      8 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (9)          (10)         (10)                                   
      Hyperplasia, Lymphoid                            2 [3.0]      3 [3.0]      3 [3.0]      2 [2.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                                           1 [2.0]                                            
   Thymus                                             (10)         (10)         (9)          (10)                                   
      Atrophy                                          3 [2.7]      3 [3.0]      2 [2.5]      1 [2.0]                               
      Cyst                                             5 [1.0]      2 [2.0]      2 [1.0]      3 [1.3]                               
      Thymocyte, Necrosis                                           1 [4.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Fibrosis                                                                   1 [3.0]                                            
      Hyperkeratosis                                                             1 [4.0]                                            
      Inflammation, Chronic Active                                               3 [3.0]                                            
      Ulcer                                                                      2 [4.0]                                            
      Epidermis, Hyperplasia, Focal                                 1 [3.0]      2 [2.0]                                            
      Site of Application - Epidermis,                                                                                              
        Hyperkeratosis                                 5 [1.4]      8 [1.0]      9 [1.4]     10 [1.0]                               
      Site of Application - Epidermis, Hyperplasia                               3 [1.3]      6 [1.3]                               
      Site of Application - Epidermis,                                                                                              
        Inflammation, Chronic Active                                             1 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:30:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
   Spinal Cord                                                                               (1)                                    
      Necrosis                                                                                1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     2 [1.5]                                                                      
      Alveolar Epithelium, Hyperplasia                                                        1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Nephropathy                                      4 [1.5]      2 [1.0]      3 [1.0]      2 [1.0]                               
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          1 [3.0]                                                                      
      Renal Tubule, Dilatation                         1 [2.0]      2 [1.5]      1 [1.0]      1 [1.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:30:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            3            1            2                                     
    Natural Death                                                   1            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            6            8            7                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Cyst                                                                       1                                                  
      Inflammation, Chronic Active                     6 [1.0]      7 [1.1]      5 [1.0]      5 [1.0]                               
      Mineralization                                   1 [1.0]                                                                      
      Hepatocyte, Necrosis                             1 [1.0]                   2 [1.0]      6 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            9 [1.1]      7 [1.3]      8 [2.3]     10 [3.0]                               
   Mesentery                                          (1)                       (2)                                                 
      Fat, Fibrosis                                                              2 [2.0]                                            
      Fat, Mineralization                              1 [1.0]                   1 [1.0]                                            
      Fat, Necrosis                                    1 [4.0]                   2 [4.0]                                            
   Salivary Glands                                                              (1)          (1)                                    
      Atrophy                                                                    1 [3.0]      1 [2.0]                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Epithelium, Hyperkeratosis                                    1 [3.0]                                                         
      Epithelium, Hyperplasia                                       1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                                                       1 [2.0]                               
      Hypertrophy                                      8 [1.9]      8 [1.9]      6 [2.0]      7 [1.3]                               
      Subcapsular, Hyperplasia                                      1 [1.0]      1 [1.0]      1 [1.0]                               
   Pituitary Gland                                    (9)          (10)         (9)          (10)                                   
      Pars Distalis, Cyst                                           2 [1.0]      1 [1.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:30:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Follicle, Degeneration                           2 [1.0]      2 [1.0]      2 [1.0]      2 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Degeneration                                     3 [4.0]      2 [4.0]      1 [4.0]      1 [4.0]                               
   Preputial Gland                                    (1)                                                                           
      Duct, Ectasia                                    1 [2.0]                                                                      
   Testes                                             (10)         (10)         (10)         (10)                                   
      Cyst                                             3 [1.7]      1 [2.0]      1 [2.0]                                            
      Germinal Epithelium, Degeneration                3 [3.7]      2 [3.0]      1 [2.0]      8 [2.3]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                         3 [3.3]      1 [3.0]      1 [3.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
   Thymus                                             (9)          (10)         (10)         (9)                                    
      Atrophy                                                       3 [2.7]      1 [3.0]      4 [2.8]                               
      Cyst                                             3 [1.0]      4 [1.3]      2 [1.5]      3 [1.7]                               
      Thymocyte, Necrosis                                                        1 [4.0]      1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (10)         (10)         (10)         (10)                                   
      Cyst Epithelial Inclusion                                                  1 [3.0]                                            
      Hyperplasia                                                                1 [3.0]      1 [4.0]                               
      Inflammation, Chronic Active                                                            2 [2.0]                               
      Epidermis, Hyperplasia, Focal                    3 [2.0]      1 [2.0]                                                         
      Sebaceous Gland, Cyst                                         1 [2.0]                                                         
      Site of Application - Dermis, Inflammation,                                                                                   
         Chronic Active                                                                       1 [2.0]                               
      Site of Application - Epidermis,                                                                                              
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-89         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: SKIN APPLICATION                         WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:30:34    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/KG      31.25        125MG/KG     500MG/KG                               
                                                                   MG/KG                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
        Hyperkeratosis                                 2 [1.0]      8 [1.3]      9 [1.6]     10 [2.1]                               
      Site of Application - Epidermis, Hyperplasia                               8 [1.3]      9 [2.2]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Alveolar Epithelium, Hyperplasia                                                        1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Cyst                                             2 [2.5]                   1 [4.0]                                            
      Infiltration Cellular, Plasma Cell                            1 [2.0]                                                         
      Mineralization                                   2 [1.0]                                                                      
      Nephropathy                                      2 [1.0]      7 [1.0]      7 [1.0]      8 [1.0]                               
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          1 [2.0]                                                                      
      Renal Tubule, Dilatation                         1 [2.0]      4 [1.5]      4 [1.8]      4 [1.5]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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