TDMS Study 97013-90 Pathology Tables
NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:33:35
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:33:35
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1
Natural Death 1
Survivors
Terminal Sacrifice 10 9 10 9
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Inflammation, Chronic Active 10 (100%) 10 (100%) 10 (100%) 9 (90%)
Hepatocyte, Fatty Change 1 (10%)
Hepatocyte, Necrosis 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 10 (100%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 2 (20%)
Subcapsular, Hyperplasia 10 (100%) 10 (100%) 9 (90%) 10 (100%)
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 1 (10%) 1 (10%)
Pars Distalis, Hyperplasia 1 (10%) 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Ectopic Thymus 1 (10%)
Infiltration Cellular, Lymphocyte 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:33:35
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Cyst 1 (10%) 1 (10%) 7 (70%)
Uterus (10) (10) (10) (10)
Inflammation, Chronic Active 2 (20%) 1 (10%) 1 (10%)
Endometrium, Hyperplasia, Cystic 7 (70%) 9 (90%) 9 (90%) 9 (90%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia, Lymphoid 2 (20%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 2 (20%) 2 (20%)
Hyperplasia, Lymphoid 1 (10%)
Thymus (10) (10) (10) (10)
Atrophy 1 (10%)
Cyst 9 (90%) 8 (80%) 7 (70%) 8 (80%)
Ectopic Parathyroid Gland 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1) (1)
Hyperkeratosis 1 (100%)
Hyperplasia 1 (100%)
Inflammation, Chronic Active 1 (100%)
Ulcer 1 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:33:35
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Atrophy 1 (10%)
Metaplasia, Osseous 1 (10%)
Mineralization 2 (20%) 3 (30%)
Nephropathy 4 (40%) 4 (40%) 7 (70%) 5 (50%)
Renal Tubule, Dilatation 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:33:35
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Natural Death 1 1
Survivors
Terminal Sacrifice 9 10 9 10
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Inflammation, Chronic Active 9 (90%) 8 (80%) 7 (70%) 9 (90%)
Hepatocyte, Fatty Change 6 (60%) 5 (50%)
Hepatocyte, Necrosis 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 9 (90%) 10 (100%) 10 (100%) 10 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%) 1 (10%)
Ulcer 1 (10%) 1 (10%)
Epithelium, Hyperkeratosis 1 (10%) 1 (10%)
Epithelium, Hyperplasia 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hypertrophy 3 (30%) 3 (30%) 1 (10%)
Subcapsular, Hyperplasia 3 (30%) 5 (50%) 3 (30%) 3 (30%)
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 4 (40%) 2 (20%) 2 (20%)
Thyroid Gland (10) (10) (10) (10)
Infiltration Cellular, Lymphocyte 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:33:35
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Degeneration 1 (10%)
Inflammation, Chronic Active 3 (30%) 2 (20%) 1 (10%) 3 (30%)
Testes (10) (10) (10) (10)
Mineralization 1 (10%)
Germinal Epithelium, Degeneration 5 (50%) 4 (40%) 2 (20%) 4 (40%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia, Lymphoid 1 (10%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
Thymus (10) (10) (10) (10)
Atrophy 1 (10%)
Cyst 6 (60%) 3 (30%) 2 (20%) 2 (20%)
Ectopic Parathyroid Gland 2 (20%) 3 (30%)
Hyperplasia, Lymphoid 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:33:35
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Thrombosis 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Hydronephrosis 1 (10%)
Metaplasia, Osseous 1 (10%)
Mineralization 1 (10%)
Nephropathy 9 (90%) 6 (60%) 8 (80%) 8 (80%)
Renal Tubule, Dilatation 1 (10%) 2 (20%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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