National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16305

TDMS Study 97013-90 Pathology Tables

NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03
Route: DOSED WATER                                                                                                Time: 09:33:35

                                                         FINAL #1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:33:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                              1                                                               
    Natural Death                                                                             1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                10            9           10            9                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                    10 (100%)    10 (100%)    10 (100%)     9 (90%)                               
      Hepatocyte, Fatty Change                         1 (10%)                                                                      
      Hepatocyte, Necrosis                                                       1 (10%)                                            
      Hepatocyte, Vacuolization Cytoplasmic           10 (100%)    10 (100%)    10 (100%)    10 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                             2 (20%)                                                         
      Subcapsular, Hyperplasia                        10 (100%)    10 (100%)     9 (90%)     10 (100%)                              
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                                                        1 (10%)      1 (10%)                               
      Pars Distalis, Hyperplasia                                    1 (10%)      1 (10%)                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Ectopic Thymus                                                                          1 (10%)                               
      Infiltration Cellular, Lymphocyte                                                       2 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:33:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Cyst                                                          1 (10%)      1 (10%)      7 (70%)                               
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     2 (20%)      1 (10%)      1 (10%)                                            
      Endometrium, Hyperplasia, Cystic                 7 (70%)      9 (90%)      9 (90%)      9 (90%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                         2 (20%)                                                         
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)      2 (20%)                   2 (20%)                               
      Hyperplasia, Lymphoid                                         1 (10%)                                                         
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                                 1 (10%)                               
      Cyst                                             9 (90%)      8 (80%)      7 (70%)      8 (80%)                               
      Ectopic Parathyroid Gland                                     1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                                            (1)                       (1)                                    
      Hyperkeratosis                                                1 (100%)                                                        
      Hyperplasia                                                   1 (100%)                                                        
      Inflammation, Chronic Active                                  1 (100%)                                                        
      Ulcer                                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:33:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) FEMALE                    0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                                                 1 (10%)                               
      Metaplasia, Osseous                                                        1 (10%)                                            
      Mineralization                                                2 (20%)      3 (30%)                                            
      Nephropathy                                      4 (40%)      4 (40%)      7 (70%)      5 (50%)                               
      Renal Tubule, Dilatation                                                   1 (10%)      1 (10%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:33:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9           10            9           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)                                                                      
      Inflammation, Chronic Active                     9 (90%)      8 (80%)      7 (70%)      9 (90%)                               
      Hepatocyte, Fatty Change                         6 (60%)      5 (50%)                                                         
      Hepatocyte, Necrosis                             1 (10%)                                                                      
      Hepatocyte, Vacuolization Cytoplasmic            9 (90%)     10 (100%)    10 (100%)    10 (100%)                              
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     1 (10%)                   1 (10%)                                            
      Ulcer                                            1 (10%)                   1 (10%)                                            
      Epithelium, Hyperkeratosis                       1 (10%)                   1 (10%)                                            
      Epithelium, Hyperplasia                          1 (10%)                   1 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Hypertrophy                                      3 (30%)      3 (30%)      1 (10%)                                            
      Subcapsular, Hyperplasia                         3 (30%)      5 (50%)      3 (30%)      3 (30%)                               
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                              4 (40%)      2 (20%)      2 (20%)                                            
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Infiltration Cellular, Lymphocyte                1 (10%)      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:33:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Degeneration                                                                            1 (10%)                               
      Inflammation, Chronic Active                     3 (30%)      2 (20%)      1 (10%)      3 (30%)                               
   Testes                                             (10)         (10)         (10)         (10)                                   
      Mineralization                                                                          1 (10%)                               
      Germinal Epithelium, Degeneration                5 (50%)      4 (40%)      2 (20%)      4 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                            1 (10%)                                                                      
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 (10%)      1 (10%)                                                         
   Thymus                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                          1 (10%)                                                                      
      Cyst                                             6 (60%)      3 (30%)      2 (20%)      2 (20%)                               
      Ectopic Parathyroid Gland                                                  2 (20%)      3 (30%)                               
      Hyperplasia, Lymphoid                            1 (10%)      1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-90         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:33:35    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         P53+/-(C57BL/6) MALE                      0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Thrombosis                                                    1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Hydronephrosis                                                                          1 (10%)                               
      Metaplasia, Osseous                                                                     1 (10%)                               
      Mineralization                                   1 (10%)                                                                      
      Nephropathy                                      9 (90%)      6 (60%)      8 (80%)      8 (80%)                               
      Renal Tubule, Dilatation                         1 (10%)      2 (20%)                   1 (10%)                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
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