TDMS Study 97013-91 Pathology Tables
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:37:52
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:37:52
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 1 2
Natural Death 2 1 2
Survivors
Terminal Sacrifice 7 9 7 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Inflammation, Chronic Active 7 (70%) 10 (100%) 9 (90%) 8 (80%)
Hepatocyte, Fatty Change 1 (10%)
Hepatocyte, Necrosis 1 (10%) 1 (10%) 1 (10%) 4 (40%)
Hepatocyte, Vacuolization Cytoplasmic 7 (70%) 9 (90%) 9 (90%) 10 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperkeratosis 1 (10%)
Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 2 (20%) 2 (20%) 2 (20%) 3 (30%)
Subcapsular, Hyperplasia 3 (30%) 5 (50%) 4 (40%) 8 (80%)
Adrenal Medulla (10) (10) (10) (10)
Mineralization 1 (10%)
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 2 (20%) 2 (20%) 2 (20%) 2 (20%)
Thyroid Gland (10) (10) (10) (10)
Ectopic Thymus 1 (10%)
Follicle, Degeneration 3 (30%) 6 (60%) 5 (50%) 5 (50%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:37:52
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Cyst 7 (70%) 4 (40%) 1 (10%)
Inflammation, Chronic Active 1 (10%)
Uterus (10) (10) (10) (10)
Endometrium, Hyperplasia, Cystic 7 (70%) 9 (90%) 7 (70%) 7 (70%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia, Lymphoid 1 (10%) 1 (10%) 1 (10%)
Spleen (10) (10) (10) (10)
Atrophy 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
Thymus (10) (10) (9) (10)
Atrophy 3 (30%) 1 (10%) 1 (11%) 1 (10%)
Cyst 3 (30%) 4 (40%) 2 (22%) 5 (50%)
Ectopic Parathyroid Gland 1 (10%)
Thrombosis 1 (10%)
Thymocyte, Necrosis 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (7) (7) (7)
Hyperkeratosis 1 (14%)
Inflammation, Chronic Active 1 (14%)
Epidermis, Hyperplasia 1 (17%) 2 (29%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:37:52
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Infarct 1 (10%)
Mineralization 1 (10%)
Nephropathy 3 (30%) 5 (50%) 2 (20%) 7 (70%)
Glomerulus, Inflammation,
Membranoproliferative 3 (30%) 1 (10%) 1 (10%)
Renal Tubule, Dilatation 3 (30%) 1 (10%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:37:52
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Natural Death 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 9 9 10 10
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Inflammation, Acute 1 (10%) 1 (10%) 1 (10%)
Inflammation, Chronic Active 9 (90%) 7 (70%) 5 (50%) 7 (70%)
Hepatocyte, Necrosis 1 (10%) 1 (10%) 1 (10%) 3 (30%)
Hepatocyte, Vacuolization Cytoplasmic 9 (90%) 10 (100%) 9 (90%) 10 (100%)
Mesentery (1) (3) (1)
Fat, Fibrosis 2 (67%) 1 (100%)
Fat, Inflammation, Chronic Active 1 (33%) 1 (100%)
Fat, Necrosis 1 (100%) 3 (100%) 1 (100%)
Fat, Pigmentation 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperplasia 3 (30%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%) 1 (10%) 1 (10%)
Atypia Cellular 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
Hypertrophy 8 (80%) 6 (60%) 9 (90%) 7 (70%)
Subcapsular, Hyperplasia 2 (20%) 1 (10%) 1 (10%)
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 2 (20%) 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:37:52
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (10) (10) (10) (10)
Ectopic Thymus 1 (10%)
Infiltration Cellular, Lymphocyte 1 (10%) 1 (10%)
Follicle, Degeneration 3 (30%) 9 (90%) 5 (50%) 4 (40%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Cyst 1 (10%)
Degeneration 1 (10%) 1 (10%) 3 (30%)
Inflammation, Chronic Active 1 (10%)
Preputial Gland (2) (4) (2)
Inflammation, Chronic Active 1 (50%)
Duct, Ectasia 2 (100%) 4 (100%) 2 (100%)
Seminal Vesicle (1) (1)
Inflammation, Chronic Active 1 (100%)
Inflammation, Suppurative 1 (100%)
Testes (10) (10) (10) (10)
Cyst 1 (10%)
Mineralization 1 (10%)
Germinal Epithelium, Degeneration 1 (10%) 1 (10%) 3 (30%)
Interstitial Cell, Hyperplasia 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (2)
Lumbar, Hematopoietic Cell Proliferation 1 (100%)
Lumbar, Hyperplasia, Lymphoid 1 (100%)
Mediastinal, Hematopoietic Cell Proliferation 1 (100%)
Mediastinal, Hyperplasia, Lymphoid 1 (100%)
Mediastinal, Infiltration Cellular, Mast Cell 1 (50%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (50%)
Renal, Hematopoietic Cell Proliferation 1 (100%)
Renal, Hyperplasia, Lymphoid 1 (100%)
Lymph Node, Mandibular (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:37:52
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (10%) 1 (10%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%)
Necrosis 1 (10%)
Thymus (10) (10) (9) (10)
Atrophy 2 (20%) 1 (10%) 1 (11%)
Cyst 2 (20%) 3 (30%) 4 (44%) 3 (30%)
Ectopic Parathyroid Gland 2 (22%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (9) (9) (9) (8)
Inflammation, Chronic Active 1 (11%) 1 (13%)
Epidermis, Hyperplasia 5 (56%) 4 (44%) 1 (13%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hemorrhage 1 (10%)
Infiltration Cellular, Polymorphonuclear 1 (10%)
Inflammation, Chronic Active 2 (20%) 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:37:52
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Kidney (10) (10) (10) (10)
Infarct 1 (10%)
Inflammation, Chronic Active 1 (10%)
Mineralization 1 (10%)
Necrosis 1 (10%)
Nephropathy 9 (90%) 8 (80%) 7 (70%) 10 (100%)
Pelvis, Inflammation, Chronic 1 (10%)
Renal Tubule, Cyst 1 (10%)
Renal Tubule, Dilatation 4 (40%) 6 (60%) 6 (60%) 5 (50%)
Renal Tubule, Nephropathy 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
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