National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/11153

TDMS Study 97013-91 Pathology Tables

NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03
Route: DOSED WATER                                                                                                Time: 09:39:14

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































Note:  Animals arranged according to CID number

                                                              Page   1


NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 2| 2| 2| 2| 2| 2| 0| 2|                                            |            |
                             DAY ON TEST   | 4| 2| 8| 8| 8| 8| 8| 8| 9| 8|                                            |            |
                                           | 1| 0| 2| 2| 2| 2| 2| 2| 4| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/L                                 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                                                               |   1        |
      Anus, Squamous Cell Papilloma        |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                | X  X                    X                                                |          3 |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma              |          X  X  X     X  X                                                |          5 |
      Squamous Cell Papilloma, Multiple    |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   1        |
      Odontogenic Tumor                    |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                | X  X                    X                                                |          3 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 2| 2| 2| 2| 2| 2| 0| 2|                                            |            |
                             DAY ON TEST   | 4| 2| 8| 8| 8| 8| 8| 8| 9| 8|                                            |            |
                                           | 1| 0| 2| 2| 2| 2| 2| 2| 4| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/L                                 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Erythrocytic                | X  X                    X                                                |          3 |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                | X                       X                                                |          2 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  M  +  +  +  +  +  +  +  +                                             |   8        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                | X  X                    X                                                |          3 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    |       +  +  +  +  +  +                                                   |   6        |
      Squamous Cell Papilloma              |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 2| 2| 2| 2| 2| 2| 0| 2|                                            |            |
                             DAY ON TEST   | 4| 2| 8| 8| 8| 8| 8| 8| 9| 8|                                            |            |
                                           | 1| 0| 2| 2| 2| 2| 2| 2| 4| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/L                                 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma, Multiple    |       X  X  X  X  X                                                      |          5 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                | X  X                    X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                | X                       X                                                |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                | X  X                    X                                                |          3 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 0| 8| 8|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    500 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Lymphoma Malignant                   |    X                                                                     |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma              |    X                                                                     |          1 |
      Squamous Cell Papilloma, Multiple    | X     X  X  X     X     X                                                |          6 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                      +     +                                             |   2        |
      Odontogenic Tumor                    |                      X     X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Lymphoma Malignant                   |    X                                                                     |          1 |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 0| 8| 8|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    500 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Lymphoma Malignant                   |    X                                                                     |          1 |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                         +                                                |   1        |
      Adenoma                              |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   1        |
      Lumbar, Lymphoma Malignant           |    X                                                                     |          1 |
      Renal, Lymphoma Malignant            |    X                                                                     |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +     +  +                                             |   7        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 0| 8| 8|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    500 MG/L                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              |       X  X                                                               |          2 |
      Squamous Cell Papilloma, Multiple    |    X        X     X     X  X                                             |          5 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Lymphoma Malignant                   |    X                                                                     |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 0| 2| 2| 2| 2| 1| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 7| 8| 8| 8| 8| 3| 8|                                            |            |
                                           | 2| 0| 2| 8| 2| 2| 2| 2| 9| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1000MG/L                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma              |    X           X  X                                                      |          3 |
      Squamous Cell Papilloma, Multiple    | X     X              X     X                                             |          4 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +                 +  +                                                |   3        |
      Odontogenic Tumor                    |    X                 X  X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 0| 2| 2| 2| 2| 1| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 7| 8| 8| 8| 8| 3| 8|                                            |            |
                                           | 2| 0| 2| 8| 2| 2| 2| 2| 9| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1000MG/L                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Erythrocytic                |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                         X                                                |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +        +  +  +     +                                             |   7        |
      Squamous Cell Papilloma              | X     X        X  X                                                      |          4 |
      Squamous Cell Papilloma, Multiple    |                      X     X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 1| 2| 0| 2| 2| 2| 2| 1| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 7| 8| 8| 8| 8| 3| 8|                                            |            |
                                           | 2| 0| 2| 8| 2| 2| 2| 2| 9| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1000MG/L                               | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 0| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 0| 8| 8| 8|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 8| 9| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    2000MG/L                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Pancreas                                |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma              |             X              X                                             |          2 |
      Squamous Cell Papilloma, Multiple    |    X  X  X              X                                                |          4 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +        +  +                                                            |   3        |
      Odontogenic Tumor                    | X        X  X                                                            |          3 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 0| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 0| 8| 8| 8|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 8| 9| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    2000MG/L                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                   +                                                      |   1        |
      Mediastinal, Leukemia Erythrocytic   |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                   X                                                      |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +           +                                             |   7        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 1| 0| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 0| 8| 8| 8|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 8| 9| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    2000MG/L                               | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Squamous Cell Papilloma              | X     X     X              X                                             |          4 |
      Squamous Cell Papilloma, Multiple    |    X     X     X                                                         |          3 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar/Bronchiolar Adenoma         |    X                       X                                             |          2 |
      Leukemia Erythrocytic                |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |                   X                                                      |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 7| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma              |             X        X                                                   |          2 |
      Squamous Cell Papilloma, Multiple    |          X              X  X                                             |          3 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +  +                                                               |   2        |
      Odontogenic Tumor, Multiple          |       X  X                                                               |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 7| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         |       +        +                                                         |   2        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +  +                                             |   9        |
      Squamous Cell Papilloma, Multiple    | X  X  X  X  X  X     X  X  X                                             |          9 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 7| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    0 MG/L                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar/Bronchiolar Adenoma         |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 5| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    500 MG/L                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma              |    X           X           X                                             |          3 |
      Squamous Cell Papilloma, Multiple    |       X  X  X     X  X  X                                                |          6 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +                                                               |   1        |
      Odontogenic Tumor                    |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 5| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    500 MG/L                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         |             +        +  +  +                                             |   4        |
                                           |__________________________________________________________________________|____________|
   Seminal Vesicle                         |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +                                             |   9        |
      Squamous Cell Papilloma              |    X                                                                     |          1 |
      Squamous Cell Papilloma, Multiple    |       X  X  X  X  X  X  X  X                                             |          8 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 5| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    500 MG/L                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                   X  X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1000MG/L                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +  +                       +                                             |   3        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma              |                   X                                                      |          1 |
      Squamous Cell Papilloma, Multiple    | X        X     X     X     X                                             |          5 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +                                                               |   1        |
      Odontogenic Tumor                    |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1000MG/L                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Preputial Gland                         |                   +  +                                                   |   2        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                   +     +                                                |   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    1000MG/L                               | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +     +                                             |   9        |
      Squamous Cell Papilloma, Multiple    | X  X  X  X  X  X  X  X     X                                             |          9 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar/Bronchiolar Adenoma         |    X        X  X  X  X  X  X                                             |          7 |
      Leukemia Erythrocytic                |          X                                                               |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Leukemia Erythrocytic                |          X                                                               |          1 |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    2000MG/L                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                                                                  |   1        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hepatocellular Adenoma               |          X                                                               |          1 |
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Squamous Cell Papilloma              |       X              X                                                   |          2 |
      Squamous Cell Papilloma, Multiple    | X  X     X  X     X                                                      |          5 |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                 +                                                |   2        |
      Odontogenic Tumor                    |                         X                                                |          1 |
      Odontogenic Tumor, Multiple          |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    2000MG/L                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +     +                                             |   8        |
      Squamous Cell Papilloma, Multiple    | X  X  X  X  X     X  X     X                                             |          8 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 97013-91                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  
Study Type: 26-39 WEEKS                       WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 12/05/03    
Route: DOSED WATER                                                                                                Time: 09:39:14    
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________|__________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     A      |
    2000MG/L                               | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Alveolar/Bronchiolar Adenoma         | X           X           X                                                |          3 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------                                      
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.