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TDMS Study 97013-91 Pathology Tables

NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1                         1            2                                     
    Natural Death                                      2            1            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7            9            7            8                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     7 [1.1]     10 [1.0]      9 [1.0]      8 [1.0]                               
      Hepatocyte, Fatty Change                                                                1 [1.0]                               
      Hepatocyte, Necrosis                             1 [2.0]      1 [1.0]      1 [1.0]      4 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            7 [2.0]      9 [2.6]      9 [2.9]     10 [3.0]                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Epithelium, Hyperkeratosis                                    1 [2.0]                                                         
      Epithelium, Hyperplasia                                       1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                2 [1.0]      2 [1.5]      2 [1.5]      3 [1.3]                               
      Subcapsular, Hyperplasia                         3 [1.0]      5 [1.0]      4 [1.0]      8 [1.0]                               
   Adrenal Medulla                                    (10)         (10)         (10)         (10)                                   
      Mineralization                                                             1 [1.0]                                            
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                              2 [1.5]      2 [1.5]      2 [1.0]      2 [1.0]                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Ectopic Thymus                                                                          1 [2.0]                               
      Follicle, Degeneration                           3 [1.0]      6 [1.0]      5 [1.0]      5 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Cyst                                                          7 [2.0]      4 [2.0]      1 [2.0]                               
      Inflammation, Chronic Active                                  1 [3.0]                                                         
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Endometrium, Hyperplasia, Cystic                 7 [2.3]      9 [2.0]      7 [2.1]      7 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                         1 [3.0]      1 [2.0]      1 [2.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                       1 [3.0]                                                         
      Hematopoietic Cell Proliferation                              1 [2.0]                   1 [2.0]                               
   Thymus                                             (10)         (10)         (9)          (10)                                   
      Atrophy                                          3 [3.7]      1 [3.0]      1 [4.0]      1 [3.0]                               
      Cyst                                             3 [1.0]      4 [1.5]      2 [2.0]      5 [1.4]                               
      Ectopic Parathyroid Gland                        1 [1.0]                                                                      
      Thrombosis                                       1 [2.0]                                                                      
      Thymocyte, Necrosis                                                                     1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (6)          (7)          (7)          (7)                                    
      Hyperkeratosis                                                             1 [2.0]                                            
      Inflammation, Chronic Active                                               1 [2.0]                                            
      Epidermis, Hyperplasia                           1 [3.0]                   2 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Infarct                                                                    1 [3.0]                                            
      Mineralization                                                             1 [1.0]                                            
      Nephropathy                                      3 [1.0]      5 [1.0]      2 [1.0]      7 [1.0]                               
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          3 [2.7]                   1 [3.0]      1 [2.0]                               
      Renal Tubule, Dilatation                         3 [1.0]      1 [1.0]      2 [1.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                                                                            
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
      Inflammation, Acute                                           1 [2.0]      1 [2.0]      1 [2.0]                               
      Inflammation, Chronic Active                     9 [1.3]      7 [1.0]      5 [1.0]      7 [1.0]                               
      Hepatocyte, Necrosis                             1 [3.0]      1 [1.0]      1 [1.0]      3 [1.3]                               
      Hepatocyte, Vacuolization Cytoplasmic            9 [2.0]     10 [2.3]      9 [3.2]     10 [3.8]                               
   Mesentery                                          (1)                       (3)          (1)                                    
      Fat, Fibrosis                                                              2 [2.0]      1 [2.0]                               
      Fat, Inflammation, Chronic Active                                          1 [2.0]      1 [2.0]                               
      Fat, Necrosis                                    1 [4.0]                   3 [3.7]      1 [4.0]                               
      Fat, Pigmentation                                                                       1 [2.0]                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Epithelium, Hyperplasia                          3 [1.7]                                1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                1 [1.0]      1 [2.0]                   1 [1.0]                               
      Atypia Cellular                                                            1 [1.0]                                            
      Hematopoietic Cell Proliferation                 1 [2.0]      1 [1.0]                                                         
      Hypertrophy                                      8 [2.1]      6 [1.5]      9 [2.3]      7 [1.7]                               
      Subcapsular, Hyperplasia                         2 [1.5]      1 [1.0]      1 [1.0]                                            
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                                           2 [1.0]      1 [1.0]      1 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Ectopic Thymus                                                             1 [1.0]                                            
      Infiltration Cellular, Lymphocyte                1 [1.0]      1 [1.0]                                                         
      Follicle, Degeneration                           3 [1.0]      9 [1.1]      5 [1.2]      4 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Cyst                                                                                    1 [2.0]                               
      Degeneration                                                  1 [4.0]      1 [4.0]      3 [4.0]                               
      Inflammation, Chronic Active                     1 [2.0]                                                                      
   Preputial Gland                                    (2)          (4)          (2)                                                 
      Inflammation, Chronic Active                     1 [4.0]                                                                      
      Duct, Ectasia                                    2 [2.5]      4 [2.3]      2 [2.0]                                            
   Seminal Vesicle                                    (1)          (1)                                                              
      Inflammation, Chronic Active                     1 [4.0]                                                                      
      Inflammation, Suppurative                                     1 [4.0]                                                         
   Testes                                             (10)         (10)         (10)         (10)                                   
      Cyst                                                                       1 [2.0]                                            
      Mineralization                                                                          1 [1.0]                               
      Germinal Epithelium, Degeneration                             1 [3.0]      1 [3.0]      3 [3.7]                               
      Interstitial Cell, Hyperplasia                                             1 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                      (1)          (2)                                                 
      Lumbar, Hematopoietic Cell Proliferation                      1 [1.0]                                                         
      Lumbar, Hyperplasia, Lymphoid                                 1 [2.0]                                                         
      Mediastinal, Hematopoietic Cell Proliferation                 1 [1.0]                                                         
      Mediastinal, Hyperplasia, Lymphoid                            1 [2.0]                                                         
      Mediastinal, Infiltration Cellular, Mast Cell                              1 [3.0]                                            
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                                               1 [2.0]                                            
      Renal, Hematopoietic Cell Proliferation                       1 [1.0]                                                         
      Renal, Hyperplasia, Lymphoid                                  1 [2.0]                                                         
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                                         1 [2.0]      1 [2.0]                                            
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 [3.0]      1 [3.0]                                                         
      Necrosis                                         1 [3.0]                                                                      
   Thymus                                             (10)         (10)         (9)          (10)                                   
      Atrophy                                          2 [3.5]      1 [2.0]      1 [1.0]                                            
      Cyst                                             2 [1.5]      3 [1.3]      4 [1.3]      3 [1.0]                               
      Ectopic Parathyroid Gland                                                  2 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (9)          (9)          (9)          (8)                                    
      Inflammation, Chronic Active                                               1 [2.0]      1 [2.0]                               
      Epidermis, Hyperplasia                           5 [3.0]      4 [2.5]                   1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hemorrhage                                       1 [2.0]                                                                      
      Infiltration Cellular, Polymorphonuclear         1 [4.0]                                                                      
      Inflammation, Chronic Active                     2 [1.5]      1 [2.0]                                                         
      Alveolar Epithelium, Hyperplasia                              1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Infarct                                                       1 [4.0]                                                         
      Inflammation, Chronic Active                     1 [4.0]                                                                      
      Mineralization                                   1 [1.0]                                                                      
      Necrosis                                         1 [3.0]                                                                      
      Nephropathy                                      9 [1.0]      8 [1.3]      7 [1.0]     10 [1.0]                               
      Pelvis, Inflammation, Chronic                                 1 [2.0]                                                         
      Renal Tubule, Cyst                                                         1                                                  
      Renal Tubule, Dilatation                         4 [1.3]      6 [1.7]      6 [1.5]      5 [1.4]                               
      Renal Tubule, Nephropathy                                     1 [1.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
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