Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/11576

TDMS Study 97013-91 Pathology Tables

NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19

                                                          FINAL#1 MICE




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  79-43-6

       Lock Date:  07/31/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1                         1            2                                     
    Natural Death                                      2            1            2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                 7            9            7            8                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Inflammation, Chronic Active                     7 [1.1]     10 [1.0]      9 [1.0]      8 [1.0]                               
      Hepatocyte, Fatty Change                                                                1 [1.0]                               
      Hepatocyte, Necrosis                             1 [2.0]      1 [1.0]      1 [1.0]      4 [1.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            7 [2.0]      9 [2.6]      9 [2.9]     10 [3.0]                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Epithelium, Hyperkeratosis                                    1 [2.0]                                                         
      Epithelium, Hyperplasia                                       1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                2 [1.0]      2 [1.5]      2 [1.5]      3 [1.3]                               
      Subcapsular, Hyperplasia                         3 [1.0]      5 [1.0]      4 [1.0]      8 [1.0]                               
   Adrenal Medulla                                    (10)         (10)         (10)         (10)                                   
      Mineralization                                                             1 [1.0]                                            
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                              2 [1.5]      2 [1.5]      2 [1.0]      2 [1.0]                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Ectopic Thymus                                                                          1 [2.0]                               
      Follicle, Degeneration                           3 [1.0]      6 [1.0]      5 [1.0]      5 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (10)         (10)         (10)         (10)                                   
      Cyst                                                          7 [2.0]      4 [2.0]      1 [2.0]                               
      Inflammation, Chronic Active                                  1 [3.0]                                                         
   Uterus                                             (10)         (10)         (10)         (10)                                   
      Endometrium, Hyperplasia, Cystic                 7 [2.3]      9 [2.0]      7 [2.1]      7 [1.7]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
      Hyperplasia, Lymphoid                                         1 [3.0]      1 [2.0]      1 [2.0]                               
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Atrophy                                                       1 [3.0]                                                         
      Hematopoietic Cell Proliferation                              1 [2.0]                   1 [2.0]                               
   Thymus                                             (10)         (10)         (9)          (10)                                   
      Atrophy                                          3 [3.7]      1 [3.0]      1 [4.0]      1 [3.0]                               
      Cyst                                             3 [1.0]      4 [1.5]      2 [2.0]      5 [1.4]                               
      Ectopic Parathyroid Gland                        1 [1.0]                                                                      
      Thrombosis                                       1 [2.0]                                                                      
      Thymocyte, Necrosis                                                                     1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (6)          (7)          (7)          (7)                                    
      Hyperkeratosis                                                             1 [2.0]                                            
      Inflammation, Chronic Active                                               1 [2.0]                                            
      Epidermis, Hyperplasia                           1 [3.0]                   2 [2.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS FEMALE               0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Infarct                                                                    1 [3.0]                                            
      Mineralization                                                             1 [1.0]                                            
      Nephropathy                                      3 [1.0]      5 [1.0]      2 [1.0]      7 [1.0]                               
      Glomerulus, Inflammation,                                                                                                     
        Membranoproliferative                          3 [2.7]                   1 [3.0]      1 [2.0]                               
      Renal Tubule, Dilatation                         3 [1.0]      1 [1.0]      2 [1.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      1                                                                            
    Moribund Sacrifice                                              1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                 9            9           10           10                                     
                                                                                                                                    
  Animals Examined Microscopically                    10           10           10           10                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                              1 [2.0]                                                         
      Inflammation, Acute                                           1 [2.0]      1 [2.0]      1 [2.0]                               
      Inflammation, Chronic Active                     9 [1.3]      7 [1.0]      5 [1.0]      7 [1.0]                               
      Hepatocyte, Necrosis                             1 [3.0]      1 [1.0]      1 [1.0]      3 [1.3]                               
      Hepatocyte, Vacuolization Cytoplasmic            9 [2.0]     10 [2.3]      9 [3.2]     10 [3.8]                               
   Mesentery                                          (1)                       (3)          (1)                                    
      Fat, Fibrosis                                                              2 [2.0]      1 [2.0]                               
      Fat, Inflammation, Chronic Active                                          1 [2.0]      1 [2.0]                               
      Fat, Necrosis                                    1 [4.0]                   3 [3.7]      1 [4.0]                               
      Fat, Pigmentation                                                                       1 [2.0]                               
   Stomach, Forestomach                               (10)         (10)         (10)         (10)                                   
      Epithelium, Hyperplasia                          3 [1.7]                                1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (10)         (10)         (10)                                   
      Accessory Adrenal Cortical Nodule                1 [1.0]      1 [2.0]                   1 [1.0]                               
      Atypia Cellular                                                            1 [1.0]                                            
      Hematopoietic Cell Proliferation                 1 [2.0]      1 [1.0]                                                         
      Hypertrophy                                      8 [2.1]      6 [1.5]      9 [2.3]      7 [1.7]                               
      Subcapsular, Hyperplasia                         2 [1.5]      1 [1.0]      1 [1.0]                                            
   Pituitary Gland                                    (10)         (10)         (10)         (10)                                   
      Pars Distalis, Cyst                                           2 [1.0]      1 [1.0]      1 [1.0]                               
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (10)         (10)         (10)         (10)                                   
      Ectopic Thymus                                                             1 [1.0]                                            
      Infiltration Cellular, Lymphocyte                1 [1.0]      1 [1.0]                                                         
      Follicle, Degeneration                           3 [1.0]      9 [1.1]      5 [1.2]      4 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (10)         (10)         (10)         (10)                                   
      Cyst                                                                                    1 [2.0]                               
      Degeneration                                                  1 [4.0]      1 [4.0]      3 [4.0]                               
      Inflammation, Chronic Active                     1 [2.0]                                                                      
   Preputial Gland                                    (2)          (4)          (2)                                                 
      Inflammation, Chronic Active                     1 [4.0]                                                                      
      Duct, Ectasia                                    2 [2.5]      4 [2.3]      2 [2.0]                                            
   Seminal Vesicle                                    (1)          (1)                                                              
      Inflammation, Chronic Active                     1 [4.0]                                                                      
      Inflammation, Suppurative                                     1 [4.0]                                                         
   Testes                                             (10)         (10)         (10)         (10)                                   
      Cyst                                                                       1 [2.0]                                            
      Mineralization                                                                          1 [1.0]                               
      Germinal Epithelium, Degeneration                             1 [3.0]      1 [3.0]      3 [3.7]                               
      Interstitial Cell, Hyperplasia                                             1 [2.0]      1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                                      (1)          (2)                                                 
      Lumbar, Hematopoietic Cell Proliferation                      1 [1.0]                                                         
      Lumbar, Hyperplasia, Lymphoid                                 1 [2.0]                                                         
      Mediastinal, Hematopoietic Cell Proliferation                 1 [1.0]                                                         
      Mediastinal, Hyperplasia, Lymphoid                            1 [2.0]                                                         
      Mediastinal, Infiltration Cellular, Mast Cell                              1 [3.0]                                            
      Mediastinal, Infiltration Cellular,                                                                                           
        Histiocyte                                                               1 [2.0]                                            
      Renal, Hematopoietic Cell Proliferation                       1 [1.0]                                                         
      Renal, Hyperplasia, Lymphoid                                  1 [2.0]                                                         
   Lymph Node, Mandibular                             (10)         (10)         (10)         (10)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                                         1 [2.0]      1 [2.0]                                            
   Spleen                                             (10)         (10)         (10)         (10)                                   
      Hematopoietic Cell Proliferation                 1 [3.0]      1 [3.0]                                                         
      Necrosis                                         1 [3.0]                                                                      
   Thymus                                             (10)         (10)         (9)          (10)                                   
      Atrophy                                          2 [3.5]      1 [2.0]      1 [1.0]                                            
      Cyst                                             2 [1.5]      3 [1.3]      4 [1.3]      3 [1.0]                               
      Ectopic Parathyroid Gland                                                  2 [1.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (9)          (9)          (9)          (8)                                    
      Inflammation, Chronic Active                                               1 [2.0]      1 [2.0]                               
      Epidermis, Hyperplasia                           5 [3.0]      4 [2.5]                   1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)         (10)         (10)         (10)                                   
      Hemorrhage                                       1 [2.0]                                                                      
      Infiltration Cellular, Polymorphonuclear         1 [4.0]                                                                      
      Inflammation, Chronic Active                     2 [1.5]      1 [2.0]                                                         
      Alveolar Epithelium, Hyperplasia                              1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 97013-91         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: 26-39 WEEKS                              WITH AVERAGE SEVERITY GRADES[b]                              Date: 12/05/03    
Route: DOSED WATER                              WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                    Time: 09:42:19    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         TGAC (FVB/N) HEMIZYGOUS MALE                 0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Kidney                                             (10)         (10)         (10)         (10)                                   
      Infarct                                                       1 [4.0]                                                         
      Inflammation, Chronic Active                     1 [4.0]                                                                      
      Mineralization                                   1 [1.0]                                                                      
      Necrosis                                         1 [3.0]                                                                      
      Nephropathy                                      9 [1.0]      8 [1.3]      7 [1.0]     10 [1.0]                               
      Pelvis, Inflammation, Chronic                                 1 [2.0]                                                         
      Renal Tubule, Cyst                                                         1                                                  
      Renal Tubule, Dilatation                         4 [1.3]      6 [1.7]      6 [1.5]      5 [1.4]                               
      Renal Tubule, Nephropathy                                     1 [1.0]                                                         
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------