TDMS Study 97013-92 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 12/08/03
EXPERIMENT: 97013 TEST: 92 TIME: 14:32:29
TEST TYPE: 26-39 WEEKS CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 97013B
PATHOLOGIST: TOFT, JOHN CAS: 7789-38-0
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 MICE
REASONS FOR REMOVAL: 25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 12/08/03
EXPERIMENT: 97013 TEST: 92 TIME: 14:32:29
TEST TYPE: 26-39 WEEKS CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 97013B
PATHOLOGIST: TOFT, JOHN CAS: 7789-38-0
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 272 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 134 218 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 64 MG/KG |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 140 251 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 128 MG/KG |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 221 251 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 272 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 256 MG/KG |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 69 221 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 272 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 28 56 84 112 140 168 196 224 252 272 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 90.0 90.0 90.0 90.0 80.0 80.0 |
| | |
| | |
|64 MG/KG | 100.0 100.0 100.0 100.0 100.0 90.0 90.0 90.0 90.0 80.0 |
| | |
| | |
|128 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 90.0 80.0 |
|MG/KG | |
| | |
|256 | 100.0 100.0 90.0 90.0 90.0 90.0 90.0 90.0 80.0 80.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 64 MG/KG 128 256 |
| MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 80.0% 80.0% 80.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000N P=1.000N P=1.000N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 176.0 195.5 236.0 145.0 |
|NATURAL DEATHS (C) | (42.0) (55.5) (15.0) (76.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 252.8 256.7 264.8 246.6 |
|(STANDARD ERROR) | (14.2) (13.1) ( 5.3) (20.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 272 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG |
| --------------------- |
| |
| TOTAL 9 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 7 |
| |
| UNCENSORED DEATHS |
| 217 251 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 64 MG/KG |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 7 |
| |
| UNCENSORED DEATHS |
| 62 144 148 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 128 MG/KG |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 127 221 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 272 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 256 MG/KG |
| ---------------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 2 CENSORED DEATHS 0 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 218 257 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 272 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 28 56 84 112 140 168 196 224 252 272 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/KG | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 88.9 88.9 77.8 |
| | |
| | |
|64 MG/KG | 100.0 100.0 90.0 90.0 90.0 70.0 70.0 70.0 70.0 70.0 |
| | |
| | |
|128 | 100.0 100.0 100.0 100.0 90.0 90.0 90.0 90.0 80.0 80.0 |
|MG/KG | |
| | |
|256 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 90.0 80.0 |
|MG/KG | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/KG 64 MG/KG 128 256 |
| MG/KG MG/KG |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 77.8% 70.0% 80.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.891N P=0.929 P=1.000N P=1.000N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 234.0 118.0 174.0 237.5 |
|NATURAL DEATHS (C) | (17.0) (28.0) (47.0) (19.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 263.6 225.8 252.4 265.1 |
|(STANDARD ERROR) | ( 6.3) (24.6) (14.8) ( 5.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (SODIUM BROMATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
64 MG/KG = 2
128 MG/KG = 3
256 MG/KG = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
(NOTE: 13 obs hidden.)
P |
E |
R 100 + 1 4 1 3
C |
E |
N |
T 90 + 4 1 1 2
|
S |
U |
R 80 + 1 2 1
V |
I ---+------------+------------+------------+------------+------------+------------+------------+------------+--
V 0 5 10 15 20 25 30 35 40
A
WEEK
WATER DISINFECTION MODEL (SODIUM BROMATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG = 1
64 MG/KG = 2
128 MG/KG = 3
256 MG/KG = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1 4
|
|
|
P 95 +
E |
R |
C |
E 90 + 2 3 2 3 4
N | 1 1
T |
|
S 85 +
U |
R |
V |
I 80 + 2 2 3 4 3
V |
A | 1 1
L |
75 +
|
|
|
70 + 2 2
|
---+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--+--
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39
WEEK
NOTE: 5 obs hidden.