Share This:
https://ntp.niehs.nih.gov/go/11627

TDMS Study 97013-94 Pathology Tables

                                                                                                                                   
NTP                             FEED, WATER, AND COMPOUND CONSUMPTION TABLE                                       REPORT: EISRPT39  
LAB: Battelle Columbus                      WATER DISINFECTION MODEL (SODIUM BROMATE)                               DATE: 12/08/03  
EXPERIMENT: 97013 TEST: 94                                                                                        TIME: 14:24:06    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: 26-39 WEEKS                              ROUTE: DOSED WATER                                            NTP:  C97013H     
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                         FEED, WATER, AND COMPOUND CONSUMPTION TABLE                           REPORT: EISRPT39  
LAB: BATTELLE COLUMBUS                                WATER DISINFECTION MODEL (SODIUM BROMATE)                   DATE: 12/08/03    
EXPERIMENT: 97013 TEST: 94                                                                                        TIME: 14:29:33    
                                                                                                                                    
                                                                                                                                    
TEST TYPE: 26                                       ROUTE: DOSED WATER                                            NTP:  97013H      
CONT: N01-ES-65406                                                                                                CAS: 7789-38-0    
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                                   26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                
==================================================================================================================================  
           0 MG/L                     80 MG/L                            400 MG/L                           800 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                          DOSE/                              DOSE/                              DOSE/               
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     4.3    24.4       4.2     24.3    0.98       14      4.3     24.8    1.00       69      6.2     23.2    1.44      214       
  3     5.3    25.9       5.0     25.0    0.94       16      4.7     26.1    0.89       73      5.0     24.1    0.94      167       
  4     4.7    28.2                                          4.6     28.4    0.98       64      6.2     25.8    1.32      191       
  5     5.7    29.0                                          5.0     29.3    0.88       68      4.6     27.4    0.81      135       
  6     5.9    29.4                                          4.7     30.6    0.80       62      4.3     28.7    0.73      119       
  7     5.7    30.9       4.0     31.7    0.70       10      5.6     30.8    0.98       73      5.1     29.4    0.89      138       
  8     5.8    32.1       6.0     32.4    1.03       15      6.4     31.8    1.10       80      4.4     29.7    0.76      119       
  9     5.5    32.5       5.8     33.1    1.05       14      5.9     32.1    1.07       73      5.3     30.6    0.96      140       
 10     6.0    33.4       4.9     34.2    0.82       11      5.7     32.6    0.95       69      4.8     30.5    0.80      127       
 11     4.9    33.3       7.1     33.9    1.45       17      5.1     32.8    1.04       62      4.2     30.1    0.86      113       
 12     4.0    34.3       6.1     35.0    1.53       14      4.6     33.2    1.15       56      4.6     30.3    1.15      121       
 13     3.7    35.1       5.5     36.0    1.49       12      5.1     33.9    1.38       60      5.1     30.7    1.38      133       
 14     3.9    35.6       4.8     36.5    1.23       10      5.1     34.2    1.31       60      5.1     30.4    1.31      135       
 15     4.3    36.2       4.5     37.5    1.05       10      4.9     34.9    1.14       56      4.9     30.4    1.14      129       
 16     3.9    34.8       6.7     36.7    1.72       14      3.9     33.9    1.00       46      4.9     30.2    1.26      131       
 17     4.9    36.2       5.5     37.1    1.12       12      4.7     34.3    0.96       55      3.8     31.4    0.78       98       
 18     5.6    36.8       6.9     37.7    1.23       15      4.1     34.8    0.73       47      5.0     31.6    0.89      128       
 19     3.9    36.7       5.4     36.3    1.38       12      5.2     34.5    1.33       60      4.9     32.1    1.26      122       
 20     4.7    36.8       4.3     37.6    0.91        9      4.3     35.8    0.91       48      4.4     32.6    0.94      108       
 21     4.8    37.1       3.8     37.2    0.79        8      4.6     36.0    0.96       51      5.2     32.2    1.08      130       
 22     5.6    38.1       3.5     37.2    0.63        8      5.0     36.0    0.89       56      5.5     32.1    0.98      137       
 23     4.4    37.8       4.2     36.7    0.95        9      4.5     36.5    1.02       49      5.8     31.4    1.32      147       
 24     3.9    37.8       3.6     36.6    0.92        8      4.5     35.6    1.15       50      4.7     31.4    1.21      121       
 25     5.1    37.7       3.8     36.5    0.75        8      3.9     35.8    0.76       44      5.2     31.6    1.02      132       
 26     4.3    38.7       4.3     37.5    1.00        9      4.0     36.2    0.93       44      4.6     32.2    1.07      114       
 27     3.4    38.3       4.0     37.4    1.18        8      4.8     35.8    1.41       54      4.2     32.3    1.24      104       
 28     4.4    39.6       3.6     37.2    0.82        8      4.9     38.8    1.11       50      3.8     33.0    0.86       91       
 29     4.7    39.2       4.7     40.2    1.00        9      3.8     37.5    0.81       41      4.3     32.7    0.91      106       
 30     3.9    38.4       4.7     39.5    1.21       10      4.1     37.2    1.05       44      4.1     32.9    1.05       99       
 31     4.4    38.0       7.0     40.2    1.59       14      3.4     37.6    0.77       37      4.1     32.5    0.93      100       
 32     4.7    37.9       4.7     39.9    1.00        9      4.2     37.8    0.89       45      3.8     33.1    0.81       92       
 33     3.6    39.3       5.5     40.9    1.53       11      3.9     38.1    1.08       41      4.8     33.6    1.33      115       
 34     4.1    39.1       6.2     40.8    1.51       12      3.3     37.0    0.80       35      4.9     33.6    1.20      117       
 35     4.3    42.7       3.9     41.2    0.91        8      2.8     37.7    0.65       30      4.9     32.3    1.14      120       
 36     4.2    42.6       5.0     41.9    1.19       10      3.4     37.7    0.81       36      4.8     32.5    1.14      117       
 37     6.4    42.5       6.9     41.7    1.08       13      3.4     39.6    0.53       35      5.0     32.3    0.78      123       
 38     3.5    42.6       6.7     41.0    1.91       13      3.3     39.3    0.94       34      5.8     30.6    1.66      152       
 39     4.2    43.2       3.8     42.7    0.90        7      4.2     38.6    1.00       43      5.3     30.1    1.26      140       
 40     3.9    43.8       4.7     42.0    1.21        9      4.5     39.1    1.15       46      6.1     29.0    1.56      168       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                        
                                   26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                
==================================================================================================================================  
           0 MG/L                     80 MG/L                            400 MG/L                           800 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
 41     3.0    43.0       5.7     42.2     1.90      11      5.0     40.7     1.67      49      6.5     29.0     2.17     179       
 42     4.6    42.1       6.5     42.1     1.41      12      3.6     40.6     0.78      35      6.4     29.9     1.39     170       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.1    30.7       5.4     31.7     1.11      14      5.1     30.5     1.02      67      5.0     28.4     1.00     143       
SD(D)   0.8               1.0              0.30       2      0.6              0.15       7      0.7              0.25      31       
CV(E)  15.4              18.4             27.3     15.7     12.2             14.9     10.3     13.2             25.3     22.0       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.4    39.1       5.0     39.0     1.17      10      4.2     36.9     0.99      45      4.9     31.7     1.16     125       
SD(D)   0.7               1.1              0.33       2      0.6              0.24       8      0.7              0.29      23       
CV(E)  16.2              23.0             28.3     21.7     15.2             24.4     17.8     14.7             25.2     18.2       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                                   26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                
==================================================================================================================================  
           0 MG/L                     80 MG/L                            400 MG/L                           800 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
  2     6.4    19.6                                                                             4.2     19.3     0.66     175       
  3     5.2    20.3       4.6     20.6     0.88      18                                         4.5     21.7     0.87     165       
  4                                                                                             4.1     22.7              145       
  5     5.6    23.9       7.0     23.7     1.25      24      6.7     23.8     1.20     113      3.9     23.4     0.70     133       
  6                       6.7     24.6               22      6.7     24.6              109      3.5     24.1              116       
  7     5.7    24.6       6.4     25.1     1.12      20      6.5     24.8     1.14     104      3.9     24.4     0.68     128       
  8     4.3    26.2                                          4.3     25.7     1.00      66      3.9     24.9     0.91     125       
  9     5.1    25.0       6.0     26.2     1.18      18      4.3     25.7     0.84      68      4.0     25.2     0.78     128       
 10     5.8    25.6       6.8     26.3     1.17      21      3.8     26.0     0.66      58      3.9     25.1     0.67     123       
 11     4.5    25.3       4.9     26.3     1.09      15      4.5     25.2     1.00      71      4.2     24.6     0.93     137       
 12     4.0    25.8       5.6     26.6     1.40      17      4.4     26.2     1.10      67      3.7     24.6     0.93     120       
 13     5.0    25.8       7.1     27.1     1.42      21      4.3     27.1     0.86      63      3.8     24.1     0.76     126       
 14     4.3    26.1       5.6     27.4     1.30      16      5.5     27.0     1.28      81      3.5     24.0     0.81     118       
 15     5.3    27.6       5.4     28.5     1.02      15      5.2     27.4     0.98      75      4.9     25.2     0.92     154       
 16     5.6    28.5       3.6     27.4     0.64      11      3.9     26.8     0.70      58      5.8     24.6     1.04     187       
 17     5.2    28.8       5.2     28.1     1.00      15      4.7     28.2     0.90      66      4.9     24.9     0.94     159       
 18     5.4    28.9       4.9     29.2     0.91      14      6.0     29.0     1.11      83      6.5     27.0     1.20     193       
 19     4.6    30.4       4.3     29.6     0.93      12      4.6     30.0     1.00      61      6.3     26.4     1.37     190       
 20     4.0    29.5       5.1     29.7     1.28      14      4.0     30.1     1.00      54      6.6     26.4     1.65     200       
 21     5.1    30.2       4.9     30.1     0.96      13      3.9     29.8     0.76      53      6.1     26.4     1.20     185       
 22     3.4    30.5       5.3     29.7     1.56      14      6.0     28.3     1.76      84      5.8     26.5     1.71     175       
 23     4.6    29.8       5.7     29.9     1.24      15      5.0     28.6     1.09      70      5.7     25.9     1.24     178       
 24     4.6    32.1       5.3     29.5     1.15      14      5.3     29.9     1.15      70      4.8     25.2     1.04     151       
 25     4.9    31.8       3.3     29.7     0.67       9      3.2     30.3     0.65      42      5.4     25.9     1.10     168       
 26     4.7    32.1       4.8     29.5     1.02      13      5.1     31.7     1.09      64      4.4     26.0     0.94     135       
 27     4.8    33.8       5.4     29.2     1.13      15      4.6     32.1     0.96      57      4.5     26.6     0.94     135       
 28     4.0    34.0       4.4     30.3     1.10      12      5.1     32.8     1.28      62      3.7     27.1     0.93     110       
 29     4.3    34.2       5.1     29.9     1.19      14      5.6     33.3     1.30      67      4.1     26.4     0.95     123       
 30     4.2    33.4       4.8     30.0     1.14      13      4.7     34.2     1.12      55      4.4     27.2     1.05     128       
 31     4.5    33.4       4.1     29.7     0.91      11      4.7     34.4     1.04      55      5.4     27.8     1.20     156       
 32     4.8    33.6       5.0     29.8     1.04      13      4.1     33.6     0.85      49      5.6     28.3     1.17     160       
 33     4.6    34.6       4.5     29.5     0.98      12      4.4     34.8     0.96      51      5.3     28.3     1.15     149       
 34     4.1    35.3       4.2     28.9     1.02      12      4.2     35.2     1.02      48      4.5     27.4     1.10     131       
 35     3.5    34.9       4.4     28.3     1.26      13      3.7     34.8     1.06      42      5.2     28.8     1.49     145       
 36     3.2    34.8       4.7     29.7     1.47      13      4.9     35.6     1.53      54      4.9     28.3     1.53     139       
 37     4.9    35.3       3.8     29.1     0.78      11      4.8     36.2     0.98      53      5.2     28.5     1.06     145       
 38     4.2    35.1       5.1     29.4     1.21      14      4.4     35.6     1.05      50      5.6     28.7     1.33     155       
 39     4.2    34.8       4.1     29.5     0.98      11      4.1     35.1     0.98      47      4.7     26.9     1.12     140       
 40     4.7    34.7       4.8     29.8     1.02      13      2.9     35.1     0.62      33      5.7     24.0     1.21     191       
==================================================================================================================================  
                                                                                                                                   
                                          WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                      
                                   26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                
==================================================================================================================================  
           0 MG/L                     80 MG/L                            400 MG/L                           800 MG/L                
     ----------------    ---------------------------------  ---------------------------------  ---------------------------------    
                                           DOSE/                              DOSE/                              DOSE/              
      GRAMS    BODY      GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL           GRAMS    BODY    CONTROL             
      WATER/   WEIGHT    WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/  WATER/   WEIGHT  WATER (B)  DOSE/    
WEEK  DAY(A)  (GRAMS)    DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)  DAY(A)  (GRAMS)  (GRAMS)   DAY(C)    
==================================================================================================================================  
 41     3.9    33.9       4.6     29.2     1.18      13      3.6     33.9     0.92      43      6.3     23.6     1.62     212       
 42     4.7    33.6       4.3     29.4     0.91      12      4.2     37.8     0.89      44      6.2     23.1     1.32     215       
1 TO 13 WEEKS                                                                                                                       
----------------                                                                                                                    
MEAN    5.2    24.2       6.1     25.2     1.19      19      5.0     25.5     0.97      80      4.0     23.7     0.79     135       
SD(D)   0.7               0.9              0.17       3      1.2              0.18      22      0.3              0.11      18       
CV(E)  14.3              15.1             14.5     14.0     23.7             18.4     27.3      6.7             14.1     13.5       
14 TO 52 WEEKS                                                                                                                      
----------------                                                                                                                    
MEAN    4.5    32.3       4.7     29.3     1.07      13      4.6     32.1     1.04      58      5.2     26.4     1.18     159       
SD(D)   0.6               0.6              0.21       2      0.8              0.24      13      0.8              0.24      28       
CV(E)  12.9              12.6             19.2     13.0     16.5             23.2     22.6     15.7             20.0     17.8       
==================================================================================================================================  
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.                                                                                     
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.                                                    
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.                                                               
(D) STANDARD DEVIATION OF WEEKLY MEAN.                                                                                              
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.                                                                   
                                                                                                                                   
                      DIAGNOSTIC TRAILER REPORT                                                                                     
                      WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE                                                            
                      26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                             
=========================================================================================================                           
           0 MG/L                  80 MG/L                  400 MG/L                 800 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               23.3  10                 23.6  10                 23.6  10                 23.6  10                               
  1               23.3  10                 23.6  10                 23.6  10                 23.6  10                               
  2   4.3   166   24.4  10     4.2   166   24.3  10     4.3   498   24.8  10     6.2   166   23.2  10                               
  3   5.3   717   25.9  10     5.0   409   25.0  10     4.7   618   26.1  10     5.0   305   24.1  10                               
  4   4.7   268   28.2  10     4.7    24   28.0  10     4.6   194   28.4  10     6.2   340   25.8  10                               
  5   5.7   510   29.0  10                 29.3  10     5.0   338   29.3  10     4.6   506   27.4  10                               
  6   5.9   326   29.4  10                 30.2  10     4.7   694   30.6  10     4.3   670   28.7  10                               
  7   5.7   567   30.9  10     4.0   278   31.7  10     5.6   474   30.8  10     5.1   859   29.4  10                               
  8   5.8   382   32.1  10     6.0   184   32.4  10     6.4   304   31.8  10     4.4   552   29.7  10                               
  9   5.5   938   32.5  10     5.8   338   33.1  10     5.9   690   32.1  10     5.3  1007   30.6  10                               
 10   6.0   403   33.4  10     4.9   423   34.2  10     5.7   731   32.6  10     4.8   759   30.5  10                               
 11   4.9   563   33.3  10     7.1   268   33.9  10     5.1   959   32.8  10     4.2   737   30.1  10                               
 12   4.0   547   34.3  10     6.1   140   35.0  10     4.6   670   33.2  10     4.6   641   30.3  10                               
 13   3.7   529   35.1  10     5.5   459   36.0  10     5.1   672   33.9  10     5.1   861   30.7  10                               
 14   3.9   749   35.6  10     4.8   652   36.5   9     5.1   969   34.2  10     5.1  1072   30.4  10                               
 15   4.3   649   36.2   9     4.5   387   37.5   8     4.9   907   34.9  10     4.9  1029   30.4  10                               
 16   3.9   210   34.8   9     6.7   334   36.7   8     3.9   334   33.9  10     4.9   571   30.2  10                               
 17   4.9   262   36.2   9     5.5   472   37.1   8     4.7   379   34.3  10     3.8   833   31.4  10                               
 18   5.6   306   36.8   9     6.9   332   37.7   8     4.1   400   34.8  10     5.0   827   31.6  10                               
 19   3.9   487   36.7   9     5.4   338   36.3   8     5.2   700   34.5  10     4.9   893   32.1   9                               
 20   4.7   428   36.8   9     4.3   306   37.6   8     4.3   711   35.8  10     4.4  1000   32.6   9                               
 21   4.8   710   37.1   9     3.8   340   37.2   8     4.6   842   36.0  10     5.2  1065   32.2   9                               
 22   5.6   924   38.1   9     3.5   342   37.2   8     5.0   900   36.0   9     5.5   926   32.1   9                               
 23   4.4   614   37.8   9     4.2   269   36.7   8     4.5   755   36.5   9     5.8   942   31.4   9                               
 24   3.9   629   37.8   9     3.6   417   36.6   8     4.5   703   35.6   9     4.7  1045   31.4   9                               
 25   5.1   879   37.7   9     3.8   386   36.5   8     3.9   747   35.8   9     5.2   742   31.6   9                               
 26   4.3   942   38.7   9     4.3   243   37.5   8     4.0   651   36.2   9     4.6   885   32.2   9                               
 27   3.4  1176   38.3   9     4.0   458   37.4   8     4.8   887   35.8   9     4.2   836   32.3   9                               
 28   4.4  1249   39.6   8     3.6   518   37.2   8     4.9   921   38.8   8     3.8  1105   33.0   9                               
 29   4.7  1188   39.2   8     4.7   262   40.2   7     3.8   505   37.5   8     4.3   723   32.7   9                               
 30   3.9  1018   38.4   8     4.7   170   39.5   7     4.1   702   37.2   8     4.1   843   32.9   9                               
 31   4.4   958   38.0   8     7.0   404   40.2   7     3.4   661   37.6   8     4.1   833   32.5   9                               
 32   4.7  1348   37.9   8     4.7   338   39.9   7     4.2  1014   37.8   8     3.8   819   33.1   8                               
 33   3.6   676   39.3   7     5.5   561   40.9   7     3.9  1086   38.1   8     4.8  1017   33.6   8                               
 34   4.1   779   39.1   7     6.2   484   40.8   7     3.3   657   37.0   8     4.9   835   33.6   8                               
 35   4.3   717   42.7   6     3.9   840   41.2   7     2.8   791   37.7   8     4.9  1008   32.3   8                               
 36   4.2   836   42.6   6     5.0   461   41.9   7     3.4   909   37.7   8     4.8  1000   32.5   8                               
 37   6.4   407   42.5   6     6.9   359   41.7   7     3.4   551   39.6   7     5.0   669   32.3   7                               
 38   3.5   411   42.6   6     6.7   454   41.0   7     3.3   576   39.3   7     5.8  1054   30.6   7                               
 39   4.2   776   43.2   6     3.8   562   42.7   7     4.2   726   38.6   7     5.3   680   30.1   6                               
 40   3.9   850   43.8   6     4.7   510   42.0   7     4.5   871   39.1   7     6.1   850   29.0   6                               
 41   3.0   357   43.0   6     5.7   290   42.2   7     5.0   495   40.7   6     6.5   330   29.0   5                               
 42   4.6   798   42.1   6     6.5   508   42.1   7     3.6   336   40.6   6     6.4   504   29.9   4                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           30.1                     30.5                     30.0                     28.0                                   
14 TO 52          39.1                     39.0                     36.9                     31.7                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
                                                                                                                                   
                      DIAGNOSTIC TRAILER REPORT                                                                                     
                      WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE                                                          
                      26 DOSED WATER STUDY OF WATER DISINFECTION MODEL (SODIUM BROMATE)                                             
=========================================================================================================                           
           0 MG/L                  80 MG/L                  400 MG/L                 800 MG/L                                       
     ----------------------   ----------------------   ----------------------   ----------------------                              
     DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM   DAILY WATER  BODY  NUM                              
WEEK WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS  WATER HOURS   WGT  WGTS                             
==========================================================================================================                          
  B               19.2  10                 19.5  10                 19.2  10                 19.2  10                               
  1               19.2  10                 19.5  10                 19.2  10                 19.2  10                               
  2   6.4    97   19.6  10                 19.3  10                 19.7  10     4.2   525   19.3  10                               
  3   5.2   429   20.3  10     4.6    71   20.6  10     6.3    71   20.4  10     4.5  1639   21.7   9                               
  4   6.6   146   23.0  10                 22.0  10     6.1   121   22.9  10     4.1   582   22.7   9                               
  5   5.6   387   23.9  10     7.0   220   23.7  10     6.7   244   23.8  10     3.9  1530   23.4   9                               
  6   5.8   205   25.1  10     6.7   301   24.6  10     6.7   652   24.6  10     3.5  1304   24.1   9                               
  7   5.7   903   24.6  10     6.4    80   25.1   9     6.5   702   24.8  10     3.9  1176   24.4   9                               
  8   4.3   575   26.2  10     6.0   116   25.8   9     4.3   284   25.7  10     3.9  1344   24.9   9                               
  9   5.1  1177   25.0  10     6.0   335   26.2   9     4.3   357   25.7  10     4.0  1503   25.2   9                               
 10   5.8   973   25.6   9     6.8   205   26.3   9     3.8   280   26.0  10     3.9  1179   25.1   9                               
 11   4.5   566   25.3   9     4.9   588   26.3   9     4.5   344   25.2  10     4.2  1399   24.6   9                               
 12   4.0   595   25.8   9     5.6   336   26.6   9     4.4   501   26.2  10     3.7  1344   24.6   9                               
 13   5.0   840   25.8   9     7.1   120   27.1   9     4.3   218   27.1  10     3.8  1344   24.1   9                               
 14   4.3   757   26.1   9     5.6   312   27.4   9     5.5   724   27.0  10     3.5  1376   24.0   9                               
 15   5.3   770   27.6   8     5.4   552   28.5   9     5.2   650   27.4  10     4.9  1230   25.2   8                               
 16   5.6   286   28.5   8     3.6   167   27.4   9     3.9   167   26.8  10     5.8   620   24.6   8                               
 17   5.2   406   28.8   8     5.2   116   28.1   9     4.7   549   28.2  10     4.9   813   24.9   8                               
 18   5.4   498   28.9   8     4.9   330   29.2   9     6.0   426   29.0   9     6.5   996   27.0   7                               
 19   4.6   751   30.4   8     4.3   480   29.6   9     4.6   453   30.0   9     6.3   850   26.4   7                               
 20   4.0   500   29.5   8     5.1   379   29.7   9     4.0   351   30.1   9     6.6   664   26.4   7                               
 21   5.1   623   30.2   8     4.9   673   30.1   9     3.9   431   29.8   9     6.1   845   26.4   7                               
 22   3.4   340   30.5   8     5.3   529   29.7   8     6.0   513   28.3   8     5.8   752   26.5   7                               
 23   4.6   657   29.8   8     5.7   822   29.9   8     5.0   732   28.6   8     5.7  1033   25.9   7                               
 24   4.6   537   32.1   8     5.3   676   29.5   8     5.3   703   29.9   8     4.8   702   25.2   7                               
 25   4.9   599   31.8   8     3.3   332   29.7   8     3.2   408   30.3   8     5.4   878   25.9   7                               
 26   4.7   940   32.1   8     4.8   891   29.5   8     5.1   838   31.7   7     4.4  1013   26.0   7                               
 27   4.8   835   33.8   8     5.4  1002   29.2   8     4.6   813   32.1   7     4.5  1027   26.6   7                               
 28   4.0   785   34.0   8     4.4   573   30.3   8     5.1   542   32.8   7     3.7   668   27.1   6                               
 29   4.3   836   34.2   8     5.1   638   29.9   8     5.6   676   33.3   7     4.1  1008   26.4   6                               
 30   4.2   845   33.4   8     4.8   676   30.0   8     4.7   967   34.2   6     4.4   668   27.2   4                               
 31   4.5   812   33.4   8     4.1   432   29.7   8     4.7   496   34.4   6     5.4   357   27.8   4                               
 32   4.8  1180   33.6   8     5.0   672   29.8   8     4.1   676   33.6   6     5.6   673   28.3   4                               
 33   4.6   918   34.6   8     4.5   843   29.5   8     4.4   680   34.8   6     5.3   671   28.3   4                               
 34   4.1   917   35.3   8     4.2   754   28.9   8     4.2   624   35.2   6     4.5   680   27.4   4                               
 35   3.5   839   34.9   8     4.4   933   28.3   8     3.7   840   34.8   6     5.2   626   28.8   4                               
 36   3.2   835   34.8   7     4.7   999   29.7   8     4.9   670   35.6   6     4.9   663   28.3   4                               
 37   4.9   693   35.3   7     3.8   742   29.1   8     4.8   574   36.2   6     5.2   668   28.5   4                               
 38   4.2   818   35.1   7     5.1   556   29.4   7     4.4   835   35.6   6     5.6   680   28.7   4                               
 39   4.2  1017   34.8   7     4.1   581   29.5   7     4.1   849   35.1   6     4.7   676   26.9   4                               
 40   4.7  1020   34.7   7     4.8   995   29.8   7     2.9   680   35.1   6     5.7   510   24.0   3                               
 41   3.9   660   33.9   7     4.6   948   29.2   7     3.6   968   33.9   6     6.3   330   23.6   2                               
 42   4.7  1107   33.6   7     4.3   672   29.4   5     4.2   504   37.8   4     6.2   336   23.1   2                               
MEAN BODY WGT FOR WEEKS                                                                                                             
1 TO 13           23.8                     24.1                     24.0                     23.3                                   
14 TO 52          32.3                     29.3                     32.1                     26.4                                   
=========================================================================================================                           
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.